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https://www.readbyqxmd.com/read/29900391/data-regarding-the-effects-of-thrombin-and-dabigatran-inhibited-thrombin-on-protease-activated-receptor-1-and-activation-of-human-atrial-fibroblasts
#1
Paola Altieri, Maria Bertolotto, Patrizia Fabbi, Elena Sportelli, Manrico Balbi, Francesco Santini, Claudio Brunelli, Marco Canepa, Fabrizio Montecucco, Pietro Ameri
The data presented here are related to the research paper entitled "Thrombin induces protease-activated receptor 1 signaling and activation of human atrial fibroblasts and dabigatran prevents these effects" (Altieri et al., 2018) [1]. Data show that silencing of protease-activated receptor 1 (PAR1) prevents the activation of Fib isolated from atrial appendages of patients without atrial fibrillation (AF), as assessed by immunofluorescence for α-smooth muscle actin (αSMA) and Picro-Sirius red staining...
August 2018: Data in Brief
https://www.readbyqxmd.com/read/29858382/unraveling-the-underlying-arrhythmia-mechanism-in-persistent-atrial-fibrillation-results-from-the-starlight-study
#2
Nicholas Child, Richard H Clayton, Caroline R Roney, Jacob I Laughner, Allan Shuros, Petr Neuzil, Jan Petru, Tom Jackson, Bradley Porter, Julian Bostock, Steven A Niederer, Reza S Razavi, Christopher A Rinaldi, Peter Taggart, Matthew J Wright, Jaswinder Gill
BACKGROUND: The mechanisms that initiate and sustain persistent atrial fibrillation are not well characterized. Ablation results remain significantly worse than in paroxysmal atrial fibrillation in which the mechanism is better understood and subsequent targeted therapy has been developed. The aim of this study was to characterize and quantify patterns of activation during atrial fibrillation using contact mapping. METHODS: Patients with persistent atrial fibrillation (n=14; mean age, 61±8 years; ejection fraction, 59±10%) underwent simultaneous biatrial contact mapping with 64 electrode catheters...
June 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29807358/activation-of-tgf-%C3%AE-1-%C3%AE-sma-col-i-profibrotic-pathway-in-fibroblasts-by-galectin-3-contributes-to-atrial-fibrosis-in-experimental-models-and-patients
#3
Hua Shen, Jing Wang, Jie Min, Wang Xi, Yang Gao, Liang Yin, Yue Yu, Kai Liu, Jian Xiao, Yu-Feng Zhang, Zhi-Nong Wang
BACKGROUND/AIMS: This study aimed to evaluate whether galectin-3 (Gal-3) contributes actively to atrial fibrosis both in patients and experimental atrial fibrillation (AF) models. METHODS: Mouse HL-1 cardiomyocytes were subjected to rapid electrical stimulation (RES) to explore Gal-3 expression and secretion levels by western blotting (WB) and enzyme linked immunosorbent assay (ELISA). Neonatal rat cardiac fibroblasts were treated with conditioned culture medium and recombinant human Gal-3 to evaluate the activation of the transforming growth factor (TGF)-β1/α-smooth muscle actin (SMA)/collagen I (Col I) profibrotic pathway (WB) and fibroblast proliferation with a Cell Counting Kit-8 (CCK-8)...
May 22, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29802206/enhanced-cardiomyocyte-nlrp3-inflammasome-signaling-promotes-atrial-fibrillation
#4
Chunxia Yao, Tina Veleva, Larry Scott, Shuyi Cao, Luge Li, Gong Chen, Prince Jeyabal, Xiaolu Pan, Katherina M Alsina, Issam Abu-Taha, Shokoufeh Ghezelbash, Corey L Reynolds, Ying H Shen, Scott A LeMaire, Wilhelm Schmitz, Frank U Müller, Ali El-Armouche, N Tony Eissa, Christine Beeton, Stanley Nattel, Xander H T Wehrens, Dobromir Dobrev, Na Li
Background -Atrial fibrillation (AF) is frequently associated with enhanced inflammatory response. The "NACHT, LRR and PYD domain containing protein 3" (NLRP3)-inflammasome mediates caspase-1 activation and interleukin-1β release in immune cells, but is not known to play a role in cardiomyocytes (CMs). Here, we assessed the role of CM NLRP3-inflammasome in AF. Methods -NLRP3-inflammasome activation was assessed by immunoblot in atrial whole-tissue lysates and CMs from patients with paroxysmal (pAF) or long-standing persistent (chronic) AF (cAF)...
May 25, 2018: Circulation
https://www.readbyqxmd.com/read/29799942/association-of-burden-of-atrial-fibrillation-with-risk-of-ischemic-stroke-in-adults-with-paroxysmal-atrial-fibrillation-the-kp-rhythm-study
#5
Alan S Go, Kristi Reynolds, Jingrong Yang, Nigel Gupta, Judith Lenane, Sue Hee Sung, Teresa N Harrison, Taylor I Liu, Matthew D Solomon
Importance: Atrial fibrillation is a potent risk factor for stroke, but whether the burden of atrial fibrillation in patients with paroxysmal atrial fibrillation independently influences the risk of thromboembolism remains controversial. Objective: To determine if the burden of atrial fibrillation characterized using noninvasive, continuous ambulatory monitoring is associated with the risk of ischemic stroke or arterial thromboembolism in adults with paroxysmal atrial fibrillation...
May 16, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29780324/intercalated-disk-extracellular-nanodomain-expansion-in-patients-with-atrial-fibrillation
#6
Tristan B Raisch, Matthew S Yanoff, Timothy R Larsen, Mohammed A Farooqui, D Ryan King, Rengasayee Veeraraghavan, Robert G Gourdie, Joseph W Baker, William S Arnold, Soufian T AlMahameed, Steven Poelzing
Aims: Atrial fibrillation (AF) is the most common sustained arrhythmia. Previous evidence in animal models suggests that the gap junction (GJ) adjacent nanodomain - perinexus - is a site capable of independent intercellular communication via ephaptic transmission. Perinexal expansion is associated with slowed conduction and increased ventricular arrhythmias in animal models, but has not been studied in human tissue. The purpose of this study was to characterize the perinexus in humans and determine if perinexal expansion associates with AF...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29759706/the-human-left-atrial-venous-circulation-as-a-vascular-route-for-atrial-pharmacological-therapies-effects-of-ethanol-infusion
#7
Miguel Valderrábano, Percy Francisco Morales, Moisés Rodríguez-Mañero, Candela Lloves, Paul A Schurmann, Amish S Dave
OBJECTIVES: This study catalogued the human venous left atrium (LA) circulation system and the ablative effects of ethanol in different branches. BACKGROUND: Vascular routes to target the LA could have significant therapeutic potential. Beyond the vein of Marshall (VOM), the fluoroscopic LA venous anatomy has not been described. METHODS: Patients undergoing ethanol infusion in the VOM as adjunctive therapy to atrial fibrillation (AF) catheter ablation were included in this study...
September 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29737037/sensitivity-analysis-of-geometrical-parameters-to-study-haemodynamics-and-thrombus-formation-in-the-left-atrial-appendage
#8
Guadalupe García Isla, Andy Luis Olivares, Etelvino Silva, Marta Nuñez-García, Constantine Butakoff, Damian Sanchez-Quintana, Hernán Morales, Xavier Freixa, Jérôme Noailly, Tom de Potter, Oscar Camara
The left atrial appendage (LAA) is a complex and heterogeneous protruding structure of the left atrium (LA). In atrial fibrillation (AF) patients, it is the location where 90% of the thrombi are formed. However, the role of the LAA in thrombus formation is not fully known yet. The main goal of this work is to perform a sensitivity analysis to identify the most relevant LA and LAA morphological parameters in atrial blood flow dynamics. Simulations were run on synthetic ellipsoidal left atria models where different parameters were individually studied: pulmonary veins (PV) and mitral valve (MV) dimensions; LAA shape; and LA volume...
May 8, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29733479/levosimendan-differentially-modulates-electrophysiological-activities-of-sinoatrial-nodes-pulmonary-veins-and-the-left-and-right-atria
#9
Yung-Kuo Lin, Yao-Chang Chen, Yi-Ann Chen, Jen-Hung Huang, Shih-Ann Chen, Yi-Jen Chen
INTRODUCTION: Calcium overload increases the risk of atrial fibrillation (AF). Levosimendan, a calcium sensitizer, increases myofilament contractility. Clinical reports suggested that levosimendan might increase AF occurrence, but the electrophysiological effects of levosimendan on AF substrates and triggers (pulmonary veins, PVs) are not clear. METHODS AND RESULTS: Conventional microelectrodes were used to record action potentials (APs) in isolated rabbit PVs, sinoatrial nodes (SANs), the left atrium (LA), and right atrium (RA) before and after application of different concentrations of levosimendan with or without milrinone (a phosphodiesterase [PDE] III inhibitor), and glibenclamide (an ATP-sensitive potassium channel [KATP ] inhibitor)...
May 7, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29722572/an-innovative-appendage-invagination-procedure-to-reduce-thrombus-formation-a-numerical-model
#10
Ori Hazan, Leonid Sternik, Dar Waiss, Michael Eldar, Oshrit Hoffer, Orly Goitein, Rafael Kuperstein, Eli Konen, Zehava Ovadia-Blechman
Invagination is an innovative technique for closing the left atrial appendage (LAA) to reduce the risk of thrombi formation. The influence of LAA invagination on the flow fields in the atria was investigated based on a computational fluid dynamics. The simulation results demonstrated that the novel invagination process can eliminate low velocities (blood stasis) and low shear rate and thus decrease the risk of thrombus formation during atrial fibrillation. This innovative technique may enhance the clinical treatment of patients with atrial fibrillation by improving the atrial flow field while lowering the risk of creating emboli...
March 2018: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/29706494/is-there-a-role-for-genes-in-exercise-induced-atrial-cardiomyopathy
#11
REVIEW
Diane Fatkin, Charles D Cox, Inken G Huttner, Boris Martinac
In endurance athletes, prolonged high intensity exercise participation can have deleterious effects on the myocardium with subsequent structural and electrical remodelling. In a subset of athletes, there is a predilection for atrial involvement and the risk of atrial fibrillation (AF) is increased. The mechanisms underpinning exercise-induced atrial cardiomyopathy have yet to be fully elucidated and the contribution of an individual's genetic makeup is unknown. Some athletes may have rare genetic variants that are sufficient to cause AF irrespective of exercise exposure...
April 9, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29697213/diagnosis-and-management-of-patients-with-atrial-fibrillation
#12
Kay Elliott
Atrial fibrillation is a common cardiac arrhythmia and is the most frequent arrhythmia experienced by older people. It is caused by chaotic electrical activity in the atria, leading to an irregular and often rapid heart rate. Atrial fibrillation is associated with an increased risk of ischaemic stroke, resulting from the turbulent blood flow in the atria. This article details the presentation of, and risk factors associated with, developing atrial fibrillation, the importance of reducing the risk of adverse events such as stroke, and the treatment options available...
May 2, 2018: Nursing Standard
https://www.readbyqxmd.com/read/29688325/anatomical-hotspots-of-fractionated-electrograms-in-the-left-and-right-atrium-do-they-exist
#13
Roeliene Starreveld, Lisette J M E van der Does, Natasja M S de Groot
Aims: Targeting of complex fractionated electrograms (CFEs) in the atria is not yet beneficial in treating drug-refractory atrial fibrillation (AF). In order to gain insight into potential anatomical hotspots of fractionated electrograms, a structured literature search was performed. Methods and results: PubMed was searched for studies describing fractionation during human atrial electrophysiological measurements (n = 565), of which 36 articles described the pre-ablation distribution of fractionated electrograms for the left atrium and/or right atrium in at least four regions...
April 20, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29678813/prognostic-significance-of-nuisance-bleeding-in-anticoagulated-patients-with-atrial-fibrillation
#14
Emily C O'Brien, DaJuanicia N Holmes, Laine E Thomas, Gregg C Fonarow, Larry A Allen, Bernard J Gersh, Peter R Kowey, Daniel E Singer, Michael D Ezekowitz, Gerald V Naccarelli, Jack E Ansell, Paul S Chan, Kenneth W Mahaffey, Alan S Go, James V Freeman, James A Reiffel, Eric D Peterson, Jonathan P Piccini, Elaine M Hylek
Background -Bleeding is commonly cited as a reason for stopping oral anticoagulants (OAC). Whether minor bleeding events ("nuisance bleeding", NB) in patients with atrial fibrillation (AF) on OAC are associated with OAC discontinuation, major bleeding and stroke/systemic embolism (SSE), is unknown. Methods -Within the ORBIT-AF prospective, outpatient registry, we identified 6771 patients ≥18 years of age at 172 sites with AF and eligible followup visits. NB was ascertained from the medical record and was defined as minor bleeding that did not require medical attention (e...
April 20, 2018: Circulation
https://www.readbyqxmd.com/read/29671888/whole-exome-sequencing-reveals-microsatellite-dna-markers-for-response-to-dofetilide-initiation-in-patients-with-persistent-atrial-fibrillation-a-pilot-study
#15
Nick Kinney, Timothy R Larsen, David M Kim, Robin T Varghese, Steven Poelzing, Harold R Garner, Soufian T AlMahameed
BACKGROUND: Dofetilide is a class III antiarrhythmic drug effective for the treatment of atrial fibrillation (AF). Dofetilide initiation (DI) associates with corrected QT interval (QTc) prolongation. Significant QTc prolongation during DI mandates dose adjustment or discontinuation of the drug. Microsatellite DNA are novel genetic markers associated with congenital and acquired health conditions. HYPOTHESIS: DNA microsatellite polymorphism may associate with QTc response to dofetilide initiation in patients with persistent AF...
April 19, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29663449/mild-hypothermia-33%C3%A2-c-increases-the-inducibility-of-atrial-fibrillation-an-in-vivo-large-animal-model-study
#16
Martin Manninger, Alessio Alogna, David Zweiker, Birgit Zirngast, Stefan Reiter, Viktoria Herbst, Heinrich Maechler, Burkert M Pieske, Frank R Heinzel, Helmut Brussee, Heiner Post, Daniel Scherr
OBJECTIVE: Application of therapeutic mild hypothermia in patients after resuscitation, often accompanied by myocardial infarction, cardiogenic shock, and systemic inflammation may impact on cardiac rhythm. We therefore tested susceptibility to atrial arrhythmias during hyperthermia (HT, 40.5°C), normothermia (NT, 38.0°C), and mild hypothermia (MH, 33.0°C). METHODS: Nine healthy, anesthetized closed-chest landrace pigs were instrumented with a quadripolar stimulation catheter in the high right atrium and a decapolar catheter in the coronary sinus...
April 16, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29659148/hydrogen-sulphide-increases-pulmonary-veins-and-atrial-arrhythmogenesis-with-activation-of-protein-kinase-c
#17
Chao-Shun Chan, Yung-Kuo Lin, Yu-Hsun Kao, Yao-Chang Chen, Shih-Ann Chen, Yi-Jen Chen
Hydrogen sulphide (H2 S), one of the most common toxic air pollutants, is an important aetiology of atrial fibrillation (AF). Pulmonary veins (PVs) and left atrium (LA) are the most important AF trigger and substrate. We investigated whether H2 S may modulate the arrhythmogenesis of PVs and atria. Conventional microelectrodes and whole-cell patch clamp were performed in rabbit PV, sinoatrial node (SAN) or atrial cardiomyocytes before and after the perfusion of NaHS with or without chelerythrine (a selective PKC inhibitor), rottlerin (a specific PKC δ inhibitor) or KB-R7943 (a NCX inhibitor)...
April 16, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29615932/synaptic-plasticity-in-cardiac-innervation-and-its-potential-role-in-atrial-fibrillation
#18
REVIEW
Jesse L Ashton, Rebecca A B Burton, Gil Bub, Bruce H Smaill, Johanna M Montgomery
Synaptic plasticity is defined as the ability of synapses to change their strength of transmission. Plasticity of synaptic connections in the brain is a major focus of neuroscience research, as it is the primary mechanism underpinning learning and memory. Beyond the brain however, plasticity in peripheral neurons is less well understood, particularly in the neurons innervating the heart. The atria receive rich innervation from the autonomic branch of the peripheral nervous system. Sympathetic neurons are clustered in stellate and cervical ganglia alongside the spinal cord and extend fibers to the heart directly innervating the myocardium...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29604419/role-of-nt-proanp-and-nt-probnp-in-patients-with-atrial-fibrillation-association-with-atrial-fibrillation-progression-phenotypes
#19
Petra Büttner, Katja Schumacher, Borislav Dinov, Samira Zeynalova, Philipp Sommer, Andreas Bollmann, Daniela Husser, Gerhard Hindricks, Jelena Kornej
BACKGROUND: Electroanatomic remodeling in atrial fibrillation (AF) leads to disease initiation and perpetuation. Although atrial natriuretic peptide (ANP) is specifically expressed in the atria and is involved in atrial remodeling, B-type natriuretic peptide (BNP) is associated with mortality and cardiovascular events in AF. OBJECTIVE: The purpose of this study was to investigate the association between N-terminal (NT)-proBNP and NT-proANP levels with 3 AF progression phenotypes: persistent AF, left atrial diameter (LAD) dilation, and left atrial low-voltage areas (LVAs)...
March 29, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29598867/role-of-stress-kinase-jnk-in-binge-alcohol-evoked-atrial-arrhythmia
#20
Jiajie Yan, Justin K Thomson, Weiwei Zhao, Xianlong Gao, Fei Huang, Biyi Chen, Qingrong Liang, Long-Sheng Song, Michael Fill, Xun Ai
BACKGROUND: Excessive binge alcohol drinking has acute cardiac arrhythmogenic effects, including promotion of atrial fibrillation (AF), which underlies "Holiday Heart Syndrome." The mechanism that couples binge alcohol abuse with AF susceptibility remains unclear. We previously reported stress-activated c-Jun N-terminal kinase (JNK) signaling contributes to AF development. This is interesting because JNK is implicated in alcohol-caused organ malfunction beyond the heart. OBJECTIVES: The purpose of this study was to detail how JNK promotes binge alcohol-evoked susceptibility to AF...
April 3, 2018: Journal of the American College of Cardiology
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