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https://www.readbyqxmd.com/read/28108550/cardiac-resynchronization-therapy-in-adults-with-congenital-heart-disease
#1
Zeliha Koyak, Joris R de Groot, Ahmed Krimly, Tara M Mackay, Berto J Bouma, Candice K Silversides, Erwin N Oechslin, Ulas Hoke, Lieselot van Erven, Werner Budts, Isabelle C Van Gelder, Barbara J M Mulder, Louise Harris
AIMS: In adults with congenital heart disease (CHD) heart failure is one of the leading causes of morbidity and mortality but experience with and reported outcome of cardiac resynchronization therapy (CRT) is limited. We investigated the efficacy of CRT in adults with CHD. METHODS AND RESULTS: This was a retrospective study including 48 adults with CHD who received CRT since 2003 in four tertiary referral centres. Responders were defined as patients who showed improvement in NYHA functional class and/or systemic ventricular ejection fraction by at least one category...
January 20, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28107561/beta-blockers-for-hypertension
#2
REVIEW
Charles S Wiysonge, Hazel A Bradley, Jimmy Volmink, Bongani M Mayosi, Lionel H Opie
BACKGROUND: Beta-blockers refer to a mixed group of drugs with diverse pharmacodynamic and pharmacokinetic properties. They have shown long-term beneficial effects on mortality and cardiovascular disease (CVD) when used in people with heart failure or acute myocardial infarction. Beta-blockers were thought to have similar beneficial effects when used as first-line therapy for hypertension. However, the benefit of beta-blockers as first-line therapy for hypertension without compelling indications is controversial...
January 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28107451/effect-of-nocturnal-hemodialysis-versus-conventional-hemodialysis-on-end-stage-renal-disease-a-meta-analysis-and-systematic-review
#3
Fangjie Liu, Yiting Sun, Tianhua Xu, Li Sun, Linlin Liu, Wei Sun, Xin Feng, Jianfei Ma, Lining Wang, Li Yao
OBJECTIVES: The purpose of this study is to assess the efficacy and safety of nocturnal hemodialysis on end-stage renal disease (ESRD) patients. METHODS: We searched Medline, EmBase, and the Cochrance Central Register of Controlled Trials for studies up to January 2016. Analysis was done to compare variant outcomes of different hemodialysis schedules, including mortality, cardiovascular-associated variables, uremia-associated variables, quality of life (QOL), side-effects, and drug usage...
2017: PloS One
https://www.readbyqxmd.com/read/28107251/internet-delivered-self-management-support-for-improving-coronary-heart-disease-and-self-management-related-outcomes-a-systematic-review
#4
Jorge Palacios, Geraldine A Lee, Maria Duaso, Abigail Clifton, Ian J Norman, Derek Richards, Elizabeth Alexandra Barley
INTRODUCTION: Coronary heart disease (CHD) is associated with significant morbidity and mortality, including mental health comorbidity, which is associated with poor outcomes. Self-management is key, but there is limited access to self-management support. Internet-delivered interventions may increase access. OBJECTIVE: The aim of this study was to conduct a systematic review to (1) determine the effectiveness of Internet-delivered CHD self-management support for improving CHD, mood, and self-management related outcomes and (2) identify and describe essential components for effectiveness...
January 20, 2017: Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28106762/contribution-of-trans-fatty-acid-intake-to-coronary-heart-disease-burden-in-australia-a-modelling-study
#5
Jason H Y Wu, Miaobing Zheng, Elise Catterall, Shauna Downs, Beth Thomas, Lennert Veerman, Jan J Barendregt
Trans-fatty acids (TFAs) intake has been consistently associated with a higher risk of coronary heart disease (CHD) mortality. We provided an updated assessment of TFA intake in Australian adults in 2010 and conducted modeling to estimate CHD mortality attributable to TFA intake. Data of the 2011-2012 National Nutrition and Physical Activity Survey was used to assess TFA intake. The CHD burden attributable to TFA was calculated by comparing the current level of TFA intake to a counterfactual setting where consumption was lowered to a theoretical minimum distribution of 0...
January 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28105124/cardioprotective-effects-of-traditional-chinese-medicine-guanmaitong-on-acute-myocardial-infarction
#6
Xing-Hua Wang, Guang-Ping Li, Wan-Song Yang, Zhan-Quan Jiao, Hong-Mei Liu, Yan-Ping Ni
Guanmaitong (GMT) is a traditional Chinese herbal compound that has been used for the treatment of coronary heart disease (CHD) and other cardiovascular diseases. However, the efficacy of GMT in treating cardiovascular diseases remains unclear. The aim of the present study was to investigate the protective mechanisms and identify the targeted proteins and signaling networks associated with the physiological activity of GMT in a rat model of acute myocardial infarction (AMI). Sprague-Dawley rats were randomly allocated into five groups: Control group (sham-operated), the model group, and small, medium, and large dosage GMT groups...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28102921/perceived-consequences-changeability-and-personal-control-of-coronary-heart-disease-are-associated-with-health-related-quality-of-life
#7
Arun K Sigurdardottir, Kolbrún Sigurlásdóttir, Kjartan Ólafsson, Margrét Hrönn Svavarsdóttir
AIMS AND OBJECTIVES: To explore changes in illness perception and health-related quality of life (HRQOL) in patients with coronary heart disease (CHD) following percutaneous coronary intervention (PCI) from the time when patients were discharged from hospital and five months later and to investigate association between illness perception and physical and mental HRQOL at five months follow up. BACKGROUND: Illness perception is known to influence patients' motivation to engage in preventive behavior...
January 19, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28097840/assessment-of-lipid-profile-and-some-risk-factors-of-atherosclerosis-in-children-whose-parents-had-early-onset-coronary-artery-disease
#8
Helen Bornaun, Naci Öner, Kemal Nişli, Kazım Öztarhan, Taner Yavuz, Ümit Türkoğlu, Aygün Dindar, Rukiye Eker Ömeroglu
BACKGROUND/AIM: The objective of our study was to analyze the lipid profile and some risk factors of atherosclerosis such as oxidized-low density lipoprotein (ox-LDL), small dense LDL (sd LDL) in the offspring of patients with premature coronary heart disease (CHD). POPULATION AND METHODS: Children whose parents had early onset CHD were matched with age and sex pairs. Study and controls were analyzed for lipid levels, apolipoproteins (Apo- A,B,E), ox-LDL, sd LDL and lipoprotein (a) [Lp(a)]...
1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28097184/kif6-719arg-genetic-variant-and-risk-for-thoracic-aortic-dissection
#9
Olga A Iakoubova, Carmen H Tong, Joseph Catanese, Charles M Rowland, May M Luke, Maryann Tranquilli, John A Elefteriades
BACKGROUND: Carriers of the 719Arg variant in KIF6, compared with noncarriers, have been reported to be at greater risk for coronary heart disease (CHD) in six prospective studies. Because CHD, thoracic aortic dissection, and nondissection thoracic aortic aneurysm share some risk factors and aspects of pathophysiology, we investigated whether carriers of the 719Arg variant also have greater odds of thoracic aortic dissection or nondissected thoracic aortic aneurysm than noncarriers. METHODS: We genotyped 140 thoracic aortic dissection cases, 497 nondissection thoracic aortic aneurysm cases, and 275 disease-free controls collected in the United States, Hungary, and Greece and investigated the association between KIF6 719Arg carrier status and thoracic aortic dissection, and between KIF6 719Arg carrier status and nondissection thoracic aortic aneurysm, using logistic regression models adjusted for age, sex, hypertension, smoking, and country...
June 2016: Aorta (Stamford, Conn.)
https://www.readbyqxmd.com/read/28096241/the-chromodomain-helicase-dna-binding-chromatin-remodelers-family-traits-that-protect-from-and-promote-cancer
#10
Alea A Mills
A plethora of mutations in chromatin regulators in diverse human cancers is emerging, attesting to the pivotal role of chromatin dynamics in tumorigenesis. A recurrent theme is inactivation of the chromodomain helicase DNA-binding (CHD) family of proteins-ATP-dependent chromatin remodelers that govern the cellular machinery's access to DNA, thereby controlling fundamental processes, including transcription, proliferation, and DNA damage repair. This review highlights what is currently known about how genetic and epigenetic perturbation of CHD proteins and the pathways that they regulate set the stage for cancer, providing new insight for designing more effective anti-cancer therapies...
January 17, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/28096041/advance-care-planning-in-adults-with-congenital-heart-disease-a-patient-priority
#11
Lisa X Deng, Lacey P Gleason, Abigail M Khan, David Drajpuch, Stephanie Fuller, Leah A Goldberg, Christopher E Mascio, Sara L Partington, Lynda Tobin, Yuli Y Kim, Adrienne H Kovacs
BACKGROUND: Adult congenital heart disease (ACHD) patients with moderate or great defect complexity are at risk for premature death. Although early engagement in advance care planning (ACP) is recommended, previous research suggests that it seldom occurs. METHODS: This study investigated ACHD patient preferences for ACP and factors that impact preferences. ACHD patients completed an ACP preferences questionnaire, the Hospital Anxiety and Depression Scale and a measure of attachment styles...
January 4, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28096020/effectiveness-of-a-psychoeducation-program-on-the-quality-of-life-in-patients-with-coronary-heart-disease-a-clinical-trial
#12
Sina Valiee, Narges Sadat Razavi, Mohammad Aghajani, Zahra Bashiri
AIM: The present study was conducted to evaluate effectiveness of a psychoeducation program (PEP) on the quality of life in patients with coronary heart disease (CHD). BACKGROUND: CHD affects patients' quality of life. PEPs may be useful to help patients reach maximum functional health. METHODS: A pretest-posttest controlled clinical trial was conducted on a study population of 70 CHD patients, who were selected through convenience sampling and randomly allocated to either the intervention or the control group...
February 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28095843/the-tidal-waves-of-connected-health-devices-with-healthcare-applications-consequences-on-privacy-and-care-management-in-european-healthcare-systems
#13
Francois-André Allaert, Noël-Jean Mazen, Louis Legrand, Catherine Quantin
BACKGROUND: The market for Connected Health Devices (CHD) with healthcare applications is growing fast and should be worth several billion euros in turnover in the coming years. Their development will completely transform the organisation of our healthcare system, profoundly change the way patients are managed and revolutionizes disease prevention. MAIN BODY: The CHD with healthcare applications is a tidal wave that has societal impact calling into question the privacy of patients' personal and healthcare information and its protection in secure systems...
January 17, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28094466/effects-of-beta-blockers-on-all-cause-mortality-in-patients-with-type-2-diabetes-and-coronary-heart-disease
#14
Tetsuro Tsujimoto, Takehiro Sugiyama, Hiroshi Kajio
AIMS: Although beta-blockers can prolong survival in patients with myocardial infarction (MI) and heart failure with reduced left ventricular ejection fraction (HFrEF), use of beta-blockers in patients with diabetes may cause hypoglycaemia and weight gain, which are associated with an increased risk of death and cardiovascular events. METHODS: Using the Bypass Angioplasty Revascularization Investigation 2 Diabetes trial data, we performed Cox proportional hazards analysis to assess the effects of beta-blockers on all-cause mortality in 2,244 patients with type 2 diabetes who had stable coronary heart disease (CHD) with and without a prior history of MI/HFrEF...
January 17, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28092760/serum-brain-derived-neurotrophic-factor-and-stability-of-depressive-symptoms-in-coronary-heart-disease-patients-a-prospective-study
#15
Stella L Kuhlmann, Mira Tschorn, Volker Arolt, Katja Beer, Julia Brandt, Laura Grosse, Wilhelm Haverkamp, Jacqueline Müller-Nordhorn, Nina Rieckmann, Johannes Waltenberger, Katharina Warnke, Rainer Hellweg, Andreas Ströhle
OBJECTIVE: Brain-derived neurotrophic factor (BDNF) supports neurogenesis, angiogenesis, and promotes the survival of various cell types in the brain and the coronary system. Moreover, BDNF is associated with both coronary heart disease (CHD) and depression. The current study aims to investigate whether serum BDNF levels are associated with the course of depressive symptoms in CHD patients. METHODS: At baseline, N=225 CHD patients were enrolled while hospitalized...
December 23, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28091358/a-survey-of-exercise-advice-and-recommendations-in-united-kingdom-paediatric-cardiac-clinics
#16
Craig A Williams, Lucy Gowing, Richard Horn, Alan Graham Stuart
BACKGROUND: Physical activity and exercise have important health benefits for children and adolescents with CHD. The objective of this study was to survey the provision of advice and recommendations in United Kingdom paediatric CHD clinics. METHODS: A three-page questionnaire was sent out to paediatric cardiac consultants in the United Kingdom, paediatric consultants with expertise in cardiology, and nursing staff (Paediatricians with Expertise in Cardiology Special Interest Group), as well as all members of the British Congenital Cardiovascular Association...
January 16, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28091357/assessment-of-the-need-for-a-cardiac-morphology-curriculum-for-paediatric-cardiology-fellows
#17
Lindsay S Rogers, Melissa Klein, Jeanne James, Michael FitzGerald
BACKGROUND: Expert knowledge of cardiac malformations is essential for paediatric cardiologists. Current cardiac morphology fellowship teaching format, content, and nomenclature are left up to the discretion of the individual fellowship programmes. We aimed to assess practices and barriers in morphology education, perceived effectiveness of current curricula, and preferences for a standardised fellow morphology curriculum. METHODS: A web-based survey was developed de novo and administered anonymously via e-mail to all paediatric cardiology fellowship programme directors and associate directors in the United States of America; leaders were asked to forward the survey to fellows...
January 16, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28090526/the-necessity-to-restore-the-anatomic-hip-centre-in-congenital-hip-disease
#18
COMMENT
George A Macheras, Panagiotis Lepetsos, Panagiotis P Anastasopoulos, Spyridon P Galanakos
Total hip replacement (THR) is the treatment of choice for the patient suffering from end-stage hip osteoarthritis. In the presence of deformities due to congenital hip disease (CHD), THR is, in most of the cases, a difficult task, since the technique of performing such an operation is demanding and the results could vary. We present our experience and preferred strategies focusing on challenges and surgical techniques associated with reconstructing the dysplastic hip.
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28088921/red-flags-a-case-series-of-clinician-family-communication-challenges-in-the-context-of-chd
#19
Priya Sekar, Katie L Marcus, Erin P Williams, Renee D Boss
We describe three cases of newborns with complex CHD characterised by communication challenges. These communication challenges were categorised as patient, family, or system-related red flags. Strategies for addressing these red flags were proposed, for the goal of optimising care and improving quality of life in this vulnerable population.
January 16, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28087154/evaluation-of-serial-high-sensitivity-troponin-t-levels-in-individuals-without-overt-coronary-heart-disease-following-exercise-stress-testing
#20
Yousef M E Saad, Hanan Idris, Ibrahim M Shugman, Krishna K Kadappu, Rohan Rajaratnam, Liza Thomas, Christian Mussap, Dominic Y C Leung, Craig P Juergens, John K French
BACKGROUND: Detectable levels of high sensitivity (cardiac) troponin T (HsTnT), occur in the majority of patients with stable coronary heart disease (CHD), and often in 'healthy' individuals. Extreme physical activity may lead to marked elevations in creatine kinase MB and TnT levels. However, whether HsTnT elevations occur commonly after exercise stress testing (EST), and if so, whether this has clinical significance, needs clarification. METHODS: To determine whether HsTnT levels become elevated after EST (Bruce protocol) to ≥95% of predicted maximum heart rate in presumed healthy subjects without overt CHD, we assayed HsTnT levels for ∼5h post-EST in 105 subjects (median age 37 years)...
December 9, 2016: Heart, Lung & Circulation
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