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Maternal -baby play

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https://www.readbyqxmd.com/read/29775245/subunits-of-the-dna-polymerase-alpha-primase-complex-promote-notch-mediated-proliferation-with-discrete-and-shared-functions-in-c-elegans-germline
#1
Dong Suk Yoon, Dong Seok Cha, Mohammad A Alfhili, Brett D Keiper, Myon-Hee Lee
Notch receptor signaling is a highly conserved cell communication system in most multicellular organisms and plays a critical role at several junctures in animal development. In C. elegans, GLP-1/Notch signaling is essential for both germline stem cell maintenance and germ cell proliferation during gonad development. Here, we show that subunits (POLA-1, DIV-1, PRI-1, and PRI-2) of the DNA polymerase alpha-primase complex are required for germ cell proliferation in response to GLP-1/Notch signaling in different tissues at different developmental stages...
May 18, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29771920/maternal-human-telomerase-reverse-transcriptase-variants-are-associated-with-preterm-labor-and-preterm-premature-rupture-of-membranes
#2
Caroline Marrs, Kevin Chesmore, Ramkumar Menon, Scott Williams
OBJECTIVE: Premature aging and short telomere lengths of fetal tissues are associated with spontaneous preterm labor (PTL) and preterm premature rupture of membranes (pPROM). Maintenance of telomere length is performed by the enzyme telomerase. Human telomerase reverse transcriptase (hTERT) is a subunit of telomerase, and its dysfunction affects telomere shortening. This study assessed whether maternal or fetal genetic variations in the hTERT gene are associated with PTL or pPROM. METHODS: A case (PTL or pPROM) control (term birth) genetic association study was conducted in 654 non-Hispanic white mothers (438 term, 162 PTL, 54 pPROM) and 502 non-Hispanic white newborns (346 term, 116 PTB, 40 pPROM)...
2018: PloS One
https://www.readbyqxmd.com/read/29771224/discipline-specific-competency-based-curricula-for-leadership-learning-in-medical-specialty-training
#3
Sandra Turner, Ming-Ka Chan, Judy McKimm, Graham Dickson, Timothy Shaw
Purpose Doctors play a central role in leading improvements to healthcare systems. Leadership knowledge and skills are not inherent, however, and need to be learned. General frameworks for medical leadership guide curriculum development in this area. Explicit discipline-linked competency sets and programmes provide context for learning and likely enhance specialty trainees' capability for leadership at all levels. The aim of this review was to summarise the scholarly literature available around medical specialty-specific competency-based curricula for leadership in the post-graduate training space...
May 8, 2018: Leadership in Health Services
https://www.readbyqxmd.com/read/29769775/primary-gingival-tuberculosis-in-pregnancy-a-rare-combination
#4
Shweta Sharma, Abdul Ahad, Narinder Dev Gupta, Vivek Kumar Sharma
Tuberculosis (TB), a common chronic-specific granulomatous disease, has become rare in the developed countries. However, it is still a common cause of morbidity and mortality in India. Although it commonly involves the lungs, its presentation in the oral cavity is quite uncommon. The very rare incidence of primary gingival TB, particularly in the absence of active pulmonary involvement often leads to misdiagnosis. Clinical features of oral lesions may include ulceration, nodules, granulomas, and fissures. TB in pregnant women is a major cause of obstetric complications and increased risk of maternal and child mortality...
March 2018: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29769104/prevalence-of-emergency-contraceptive-pill-use-among-spanish-adolescent-girls-and-their-family-and-psychological-profiles
#5
Antonia Jiménez-Iglesias, Carmen Moreno, Irene García-Moya, Francisco Rivera
BACKGROUND: Adolescent girls' family context and psychological characteristics play important roles in their sexual behavior, including the use of the emergency contraceptive pill (ECP). This study aims to (1) determine the prevalence of ECP use among girls who have had sexual intercourse and (2) comparatively analyze their family and psychological profiles according to whether they have used ECPs. METHODS: The sample of 1735 Spanish girls aged 15 to 18 came from a representative sample of the 2014 edition of the Health Behaviour in School-aged Children (HBSC) study...
May 16, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29766498/routine-language-speech-directed-to-infants-during-home-activities
#6
Catherine S Tamis-LeMonda, Stephanie Custode, Yana Kuchirko, Kelly Escobar, Tiffany Lo
Everyday activities are replete with contextual cues for infants to exploit in the service of learning words. Nelson's (1985) script theory guided the hypothesis that infants participate in a set of predictable activities over the course of a day that provide them with opportunities to hear unique language functions and forms. Mothers and their firstborn 13-month-old infants (N = 40) were video-recorded during everyday activities at home. Transcriptions and coding of mothers' speech to infants-time-locked to activities of feeding, grooming, booksharing, object play, and transition-revealed that the amount, diversity, pragmatic functions, and semantic content of maternal language systematically differed by activity...
May 15, 2018: Child Development
https://www.readbyqxmd.com/read/29766369/nutritional-issues-in-food-allergy
#7
REVIEW
Isabel J Skypala, Rebecca McKenzie
Diet and nutrition play an important role in the development and management of food allergy. The diet of expectant mothers can have an effect on their offspring in terms of allergic outcomes. A host of confounding factors may influence this, with a maternal diet rich in fruits and vegetables, fish, vitamin D-rich foods associated with a lower risk of allergic disease in their children. More surprisingly, the consumption of milk and butter has also been shown to have a protective effect, especially in a farm environment...
May 15, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29762734/estimation-of-direct-and-maternal-genetic-parameters-for-individual-birth-weight-weaning-weight-and-probe-weight-in-yorkshire-and-landrace-pigs
#8
K Alves, F S Schenkel, L F Brito, J A B Robinson
As a result of selecting for increased litter size, newborn piglets are being born lighter and have a lower chance of survival. Raising fewer pigs to market weight would have a negative impact on the industry and farmer profitability, thus understanding the genetics of individual growth performance traits will determine whether these traits will play an important role in pig breeding schemes. This study aimed to estimate genetic parameters for individual birth weight (BW), weaning weight (WW) and probe weight (PW) in Canadian purebred Yorkshire and Landrace pigs...
May 12, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29761052/asymmetries-in-mother-infant-behaviour-in-barbary-macaques-macaca-sylvanus
#9
Barbara Regaiolli, Caterina Spiezio, William Donald Hopkins
Asymmetries in the maternal behaviour and anatomy might play an important role in the development of primate manual lateralization. In particular, early life asymmetries in mother's and infant's behaviour have been suggested to be associated with the development of the hand preference of the offspring. The aim of this study was to investigate the presence of behavioural asymmetries in different behavioural categories of mother-infant dyads of zoo-living Barbary macaques ( Macaca sylvanus ). The study subjects were 14 Barbary macaques involved in seven mother-infant dyads housed in Parco Natura Viva, Italy...
2018: PeerJ
https://www.readbyqxmd.com/read/29760714/fine-mapping-and-candidate-gene-identification-for-wax-biosynthesis-locus-bowax1-in-brassica-oleracea-l-var-capitata
#10
Dongming Liu, Xin Dong, Zezhou Liu, Jun Tang, Mu Zhuang, Yangyong Zhang, Honghao Lv, Yumei Liu, Zhansheng Li, Zhiyuan Fang, Limei Yang
Cuticular waxes play important roles in plant protection against various biotic and abiotic environmental stresses. The cuticular wax covering gives normal cabbage a glaucous appearance, but the appearance of waxless mutant is glossy green. Based on the present study, inheritance of the glossy green character of mutant HUAYOU2 follows a simple recessive pattern. Genetic analysis of an F2 population comprising 808 recessive individuals derived from HUAYOU2 (P1 , maternal parent) and M36 (P2 , paternal parent) revealed that a single recessive locus, BoWax1 ( Brassica oleracea Wax 1 ), controls glossy green trait in B ...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29758271/an-investigation-of-maternal-food-intake-and-maternal-food-talk-as-predictors-of-child-food-intake
#11
Jasmine M DeJesus, Susan A Gelman, Gail B Viechnicki, Danielle P Appugliese, Alison L Miller, Katherine L Rosenblum, Julie C Lumeng
Though parental modeling is thought to play a critical role in promoting children's healthy eating, little research has examined maternal food intake and maternal food talk as independent predictors of children's food intake. The present study examines maternal food talk during a structured eating protocol, in which mothers and their children had the opportunity to eat a series of familiar and unfamiliar vegetables and desserts. Several aspects of maternal talk during the protocol were coded, including overall food talk, directives, pronoun use, and questions...
May 11, 2018: Appetite
https://www.readbyqxmd.com/read/29758096/low-maternal-serum-concentrations-of-mannose-binding-lectin-mbl-are-associated-with-the-risk-of-shorter-duration-of-pregnancy-and-lower-birth-weight
#12
Michal Koucký, Karin Malíčková, Helena Kopřivová, Tereza Cindrová-Davies, Hana Hrbáčková, Andrej Černý, Patrik Šimják, Antonín Pařízek, Tomáš Zima
BACKROUND: Chronic inflammation has been implicated as the underlying mechanism responsible for the pathophysiology of preterm labor. Mannose-bindig lectin (MBL) plays a central role in the innate immune response and is thus an important component of the first line of defense. The aim of this study was to investigate whether serum concentrations of MBL correlated with the incidence of preterm birth and low birth weight in a cohort of women with signs of threatened preterm birth. METHODS: A cohort of 60 patients who presented with regular contractions and/or short cervix (group A) between 24 to 32 weeks of gestation and 20 healthy controls (group B) who had no pregnancy complications and delivered at term were recruited into a prospective study...
May 14, 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29754762/developmental-delay-in-communication-among-toddlers-and-its-relationship-to-caregiving-behavior-among-violence-exposed-posttraumatically-stressed-mothers
#13
R Torrisi, E Arnautovic, V C Pointet Perizzolo, M Vital, A Manini, F Suardi, M Gex-Fabry, S Rusconi Serpa, D S Schechter
OBJECTIVES: This study aimed to understand if maternal interpersonal violence-related posttraumatic stress disorder (IPV-PTSD) is associated with delayed language development among very young children ("toddlers"). METHODS: Data were collected from 61 mothers and toddlers (ages 12-42 months, mean age = 25.6 months SD = 8.70). Child expressive and receptive language development was assessed by the Ages and Stages Questionnaire (ASQ) communication subscale (ASQCS) that measures language acquisition...
May 10, 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29753459/infant-handling-in-bonobos-pan-paniscus-exploring-functional-hypotheses-and-the-relationship-to-oxytocin
#14
Klaree Boose, Frances White, Colin Brand, Audra Meinelt, Josh Snodgrass
Infant handling describes interactions between infants and non-maternal group members and is widespread across mammalian taxa. The expression of infant handling behaviors, defined as any affiliative or agonistic interaction between a group member and an infant, varies considerably among primate species. Several functional hypotheses may explain the adaptive value of infant handling including the Kin Selection hypothesis, which describes handling as a mechanism through which indirect fitness is increased and predicts a bias in handling behaviors directed toward related (genetic) infants; the Alliance Formation hypothesis, which describes handling as a social commodity and predicts females with infants will support handlers during conflict; and the Learning-to-Mother hypothesis, which describes handling as a mechanism through which handlers learn species-specific maternal behaviors and predicts that handling will occur most frequently in immature and nulliparous females...
May 9, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29751847/asf1-is-required-to-load-histones-on-the-hira-complex-in-preparation-of-paternal-chromatin-assembly-at-fertilization
#15
Béatrice Horard, Laure Sapey-Triomphe, Emilie Bonnefoy, Benjamin Loppin
BACKGROUND: Anti-Silencing Factor 1 (ASF1) is a conserved H3-H4 histone chaperone involved in both Replication-Coupled and Replication-Independent (RI) nucleosome assembly pathways. At DNA replication forks, ASF1 plays an important role in regulating the supply of H3.1/2 and H4 to the CAF-1 chromatin assembly complex. ASF1 also provides H3.3-H4 dimers to HIRA and DAXX chaperones for RI nucleosome assembly. The early Drosophila embryo is an attractive system to study chromatin assembly in a developmental context...
May 11, 2018: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/29748441/maternal-embryonic-leucine-zipper-kinase-inhibitor-otssp167-has-preclinical-activity-on-multiple-myeloma-bone-disease
#16
Joséphine Muller, Arnold Bolomsky, Sophie Dubois, Elodie Duray, Kathrin Stangelberger, Erwan Plougonven, Margaux Lejeune, Angélique Léonard, Caroline Marty, Ute Hempel, Frédéric Baron, Yves Beguin, Martine Cohen-Solal, Heinz Ludwig, Roy Heusschen, Jo Caers
Multiple myeloma bone disease is characterized by an uncoupling of bone remodeling in the multiple myeloma microenvironment, resulting in the development of lytic bone lesions. Most myeloma patients suffer from these bone lesions, which not only causes morbidity but also negatively impacts survival. The development of novel therapies, ideally with a combined anti-resorptive and bone-anabolic effect, is of great interest because lesions persist with the current standard of care, even in patients in complete remission...
May 10, 2018: Haematologica
https://www.readbyqxmd.com/read/29748248/bromodomain-protein-brd4-is-increased-in-human-placentas-from-women-with-early-onset-preeclampsia
#17
Stella Liong, Gillian Barker, Martha Lappas
Preeclampsia affects 5% of all pregnancies and is a serious disorder of pregnancy, characterised by high maternal blood pressure, placental hypoxia, fluid retention (oedema) and proteinuria. Women with preeclampsia are associated with exaggerated levels of pro-inflammatory cytokines, chemokines and anti-angiogenic factors such as soluble fms-like tyrosine kinase-1 (sFLT1). Studies in non-gestational tissues have described the bromodomain (BRD) and extraterminal family of proteins, in particular BRD4 to play a critical role in propagating inflammation and is currently a therapeutic target for treating cancer, lung inflammation and asthma...
June 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29748217/maternally-derived-yolk-antioxidants-buffer-the-developing-avian-embryo-against-oxidative-stress-induced-by-hyperoxia
#18
Hannah Watson, Pablo Salmón, Caroline Isaksson
In oviparous animals, maternally transferred antioxidants protect the embryo from oxidative damage from high rates of reactive oxygen species (ROS) production incurred by rapid growth. Elevated ROS exposure - beyond that incurred by normal growth - can occur as a result of exposure to exogenous factors (e.g. pollutants, toxins, radiation), increasing the risk of oxidative damage, with potentially adverse consequences for embryonic development and long-term fitness. The capacity of the avian embryo's antioxidant protection system to counter an increased exogenous oxidative threat is poorly understood...
May 10, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29747669/role-of-the-general-practitioner-in-improving-rural-healthcare-access-a-case-from-nepal
#19
Bikash Gauchan, Stephen Mehanni, Pawan Agrawal, Mandeep Pathak, Santosh Dhungana
BACKGROUND: There is a global health workforce shortage, which is considered critical in Nepal, a low-income country with a predominantly rural population. General practitioners (GPs) may play a key role improving access to essential health services in rural Nepal, though they are currently underrepresented at the district hospital level. The objective of this paper is to describe how GPs are adding value in rural Nepal by exploring clinical, leadership, and educational roles currently performed in a rural district-level hospital...
May 10, 2018: Human Resources for Health
https://www.readbyqxmd.com/read/29744286/adolescent-pregnancy-and-challenges-in-kenyan-context-perspectives-from-multiple-community-stakeholders
#20
Manasi Kumar, Keng-Yen Huang, Caleb Othieno, Dalton Wamalwa, Beatrice Madeghe, Judith Osok, Simon Njuguna Kahonge, Joyce Nato, Mary McKernon McKay
Objective: The key objective of this paper is to provide a phenomenological account of the mental health challenges and experiences of adolescent new mothers. We explore the role of social support and the absence of empathy plays in depression among pregnant adolescents. The project also collected data on the adolescents' caregiving environment which includes the adolescents' mothers, their partners, the community, and health care workers, as well as feedback from staff nurses at the maternal and child health centers...
March 2018: Global Social Welfare: Research, Policy & Practice
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