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Serum uric acid AND cognition

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https://www.readbyqxmd.com/read/27916816/blueberry-consumption-affects-serum-uric-acid-concentrations-in-older-adults-in-a-sex-specific-manner
#1
Carol L Cheatham, Itzel Vazquez-Vidal, Amanda Medlin, V Saroja Voruganti
Blueberries are rich in antioxidants and may protect against disease. Uric acid accounts for about 50% of the antioxidant properties in humans. Elevated levels of serum uric acid (SUA) or hyperuricemia is a risk factor for cardiovascular disease (CVD). The aim was to determine the effect of blueberries on SUA in older adults. Participants (n = 133, 65-80 years) experiencing mild cognitive impairment (MCI) were randomized in a double-blind 6-month clinical trial to either blueberry or placebo. A reference group with no MCI received no treatment...
November 29, 2016: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/27890742/serum-uric-acid-and-impaired-cognitive-function-in-community-dwelling-elderly-in-beijing
#2
Shuangling Xiu, Zheng Zheng, Shaochen Guan, Jin Zhang, Jinghong Ma, Piu Chan
The relationship between serum uric acid (sUA) and cognitive function is contradictory. This study assessed the association between sUA and cognitive impairment in 10,039 community-dwelling subjects aged ≥55years living in Beijing, China. Participants underwent determination of sUA and an evaluation of cognitive function using the scholarship-adjusted Mini-Mental State Examination (MMSE): MMSE ≤17 for illiterates; MMSE≤20 for primary school graduates (≥6years of education); and MMSE≤24 for junior school graduates or above (≥9years of education)...
November 24, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27785947/increased-non-protein-bound-iron-in-down-syndrome-contribution-to-lipid-peroxidation-and-cognitive-decline
#3
Caterina Manna, Arbace Officioso, Francesca Trojsi, Gioacchino Tedeschi, Silvia Leoncini, Cinzia Signorini, Lucia Ciccoli, Claudio De Felice
Down syndrome (DS, trisomy 21) is the leading cause of chromosomal-related intellectual disability. At an early age, adults with DS develop with the neuropathological hallmarks of Alzheimer's disease, associated with a chronic oxidative stress. To investigate if non-protein bound iron (NPBI) can contribute to building up a pro-oxidative microenvironment, we evaluated NPBI in both plasma and erythrocytes from DS and age-matched controls, together with in vivo markers of lipid peroxidation (F2-isoprostanes; F2-dihomo-isoprostanes; F4-neuroprostanes) and in vitro reactive oxygen species (ROS) formation in erythrocytes...
October 27, 2016: Free Radical Research
https://www.readbyqxmd.com/read/27682634/lower-serum-uric-acid-is-associated-with-mild-cognitive-impairment-in-early-parkinson-s-disease-a-4-year-follow-up-study
#4
Maria Teresa Pellecchia, Riccardo Savastano, Marcello Moccia, Marina Picillo, Pietro Siano, Roberto Erro, Annamaria Vallelunga, Marianna Amboni, Carmine Vitale, Gabriella Santangelo, Paolo Barone
Cognitive deficits are common in Parkinson's disease (PD) and many patients eventually develop dementia; however, its occurrence is unpredictable. Serum uric acid (UA) has been proposed as a biomarker of PD, both in the preclinical and clinical phase of the disease. The aim of this pilot study was to evaluate relationships between baseline serum UA levels and occurrence of mild cognitive impairment (MCI) at 4-year follow-up in a cohort of early PD patients. Early PD patients, not presenting concomitant diseases, cognitive impairment or treatment possibly interfering with UA levels, underwent neuropsychological testing at baseline and 4-year follow-up...
December 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27670212/oxidative-stress-and-environmental-exposures-are-associated-with-multiple-system-atrophy-in-chinese-patients
#5
Linli Zhou, Ying Jiang, Cansheng Zhu, Lili Ma, Qiling Huang, Xiaohong Chen
OBJECTIVE: Oxidative stress is involved in the pathogenesis of multiple system atrophy (MSA). The aim of this study is to examine oxidant biomarkers including homocysteine (Hcys), bilirubin, uric acid, lipids, and potential environmental risk factors and to ascertain whether these data correlate with MSA in a Chinese population. METHODS: In this study, serum levels of Hcys, bilirubin, uric acid, and lipids were studied in 55 MSA patients and 76 healthy controls (HCs)...
September 2016: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/27662452/elevated-cystatin-c-levels-are-associated-with-cognitive-impairment-and-progression-of-parkinson-disease
#6
Wei-Dong Hu, Jing Chen, Cheng-Jie Mao, Ping Feng, Ya-Ping Yang, Wei-Feng Luo, Chun-Feng Liu
OBJECTIVE: We investigated the relationship between serum cystatin C (CysC) levels and cognitive dysfunction and disease progression in patients with Parkinson disease. BACKGROUND: Previous studies have reported altered CysC levels in neurodegenerative disorders, but only a few studies have explored the role of CysC and its relationship to cognitive dysfunction in Parkinson disease. METHODS: We measured serum levels of CysC, creatinine, urea, and uric acid in 142 patients with Parkinson disease and 146 healthy controls...
September 2016: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://www.readbyqxmd.com/read/27193487/biomarkers-for-dementia-and-mild-cognitive-impairment-in-parkinson-s-disease
#7
REVIEW
Manuel Delgado-Alvarado, Belén Gago, Irene Navalpotro-Gomez, Haritz Jiménez-Urbieta, María C Rodriguez-Oroz
Cognitive decline is one of the most frequent and disabling nonmotor features of Parkinson's disease. Around 30% of patients with Parkinson's disease experience mild cognitive impairment, a well-established risk factor for the development of dementia. However, mild cognitive impairment in patients with Parkinson's disease is a heterogeneous entity that involves different types and extents of cognitive deficits. Because it is not currently known which type of mild cognitive impairment confers a higher risk of progression to dementia, it would be useful to define biomarkers that could identify these patients to better study disease progression and possible interventions...
June 2016: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/27114200/association-of-cognitive-function-and-serum-uric-acid-are-cardiovascular-diseases-a-mediator-among-women
#8
Laura Perna, Ute Mons, Ben Schöttker, Hermann Brenner
BACKGROUND: Several studies reported an association between concentrations of serum uric acid and cognitive function, but the evidence is contradictory. It is known that uric acid is associated with cardiovascular diseases, especially among women. Stratifying by sex and history of cardiovascular disease may clarify whether uric acid is an independent risk factor for cognitive dysfunction. METHODS: A population-based study was conducted in the German State of Saarland...
August 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/27104899/serum-uric-acid-and-its-association-with-longitudinal-cognitive-change-among-urban-adults
#9
May A Beydoun, Jose-Atilio Canas, Gregory A Dore, Hind A Beydoun, Ola S Rostant, Marie T Fanelli-Kuczmarski, Michele K Evans, Alan B Zonderman
Uric acid, a waste metabolite among humans, was linked to various cognitive outcomes. We describe sex and age-group specific associations of baseline serum uric acid (SUAbase) and significant change in SUA (ΔSUA: 1 versus 0 = decrease versus no change; 2 versus 0 = increase versus no change) with longitudinal annual rate of cognitive change among a large sample of urban adults. Data from the Healthy Aging in Neighborhoods of Diversity across the Life Span study, 2004-2009 (visit 1) and 2009-2013 (visit 2) were used...
April 21, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/26923017/metabolic-syndrome-and-mild-cognitive-impairment-a-case-control-study-among-elderly-in-a-shanghai-suburb
#10
Qian Yao, Guo-Xin Jiang, Zhi-Ming Zhou, Jin-Mei Chen, Qi Cheng
BACKGROUND: Metabolic syndrome (MetS) maybe associated with mild cognitive impairment (MCI). OBJECTIVE: To investigate the relationship between MetS, with its individual or combined components, and MCI among elderly. METHODS: A case-control study was conducted among the elderly aged 65 years and over in a community located in the southwestern suburb of Shanghai, China. The Chinese version of the Mini-Mental Status Examination (C-MMSE) was used to screen subjects with MCI...
2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/26917248/does-serum-uric-acid-act-as-a-modulator-of-cerebrospinal-fluid-alzheimer-s-disease-biomarker-related-cognitive-decline
#11
B S Ye, W W Lee, J H Ham, J J Lee, P H Lee, Y H Sohn
BACKGROUND AND PURPOSE: The association of serum uric acid, cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) and longitudinal cognitive decline was evaluated using the AD Neuroimaging Initiative database. METHODS: In 271 healthy subjects, 596 mild cognitive impairment patients and 197 AD patients, serum uric acid and CSF AD biomarkers were measured at baseline, and Mini-Mental State Examination and AD Assessment Scale - Cognitive Subscale (ADAS-cog) were assessed serially (mean duration, 2...
May 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/26911448/coppadis-2015-cohort-of-patients-with-parkinson-s-disease-in-spain-2015-a-global-clinical-evaluations-serum-biomarkers-genetic-studies-and-neuroimaging-prospective-multicenter-non-interventional-long-term-study-on-parkinson-s-disease-progression
#12
MULTICENTER STUDY
Diego Santos-García, Pablo Mir, Esther Cubo, Lydia Vela, Mari Cruz Rodríguez-Oroz, Maria José Martí, José Matías Arbelo, Jon Infante, Jaime Kulisevsky, Pablo Martínez-Martín
BACKGROUND: Parkinson's disease (PD) is a progressive neurodegenerative disorder causing motor and non-motor symptoms that can affect independence, social adjustment and the quality of life (QoL) of both patients and caregivers. Studies designed to find diagnostic and/or progression biomarkers of PD are needed. We describe here the study protocol of COPPADIS-2015 (COhort of Patients with PArkinson's DIsease in Spain, 2015), an integral PD project based on four aspects/concepts: 1) PD as a global disease (motor and non-motor symptoms); 2) QoL and caregiver issues; 3) Biomarkers; 4) Disease progression...
2016: BMC Neurology
https://www.readbyqxmd.com/read/26820749/serum-uric-acid-level-and-association-with-cognitive-impairment-and-dementia-systematic-review-and-meta-analysis
#13
REVIEW
Aamir A Khan, Terence J Quinn, Jonathan Hewitt, Yuhua Fan, Jesse Dawson
Serum uric acid (sUA) level may be associated with cognitive impairment/dementia. It is possible this relationship varies with dementia subtype, particularly between vascular dementias (VaD) and Alzheimer's (AD) or Parkinson's disease (PDD)-related dementia. We aimed to present a synthesis of all published data on sUA and relationship with dementia/cognition through systematic review and meta-analysis. We included studies that assessed the association between sUA and any measure of cognitive function or a clinical diagnosis of dementia...
February 2016: Age (2005-)
https://www.readbyqxmd.com/read/26747207/chronical-sleep-interruption-induced-cognitive-decline-assessed-by-a-metabolomics-method
#14
Li Feng, Hong-wei Wu, Guang-qing Song, Cong Lu, Ying-hui Li, Li-na Qu, Shan-guang Chen, Xin-min Liu, Qi Chang
Good sleep is necessary for optimal health, especially for mental health. Insomnia, sleep deprivation will make your ability to learn and memory impaired. Nevertheless, the underlying pathophysiological mechanism of sleep disorders-induced cognitive decline is still largely unknown. In this study, the sleep deprivation of animal model was induced by chronical sleep interruption (CSI), the behavioral tests, biochemical index determinations, and a liquid chromatography-mass spectrometry (LC-MS) based serum metabolic profiling analysis were performed to explore the effects of CSI on cognitive function and the underlying mechanisms...
April 1, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/26739446/serum-uric-acid-is-associated-with-apathy-in-early-drug-na%C3%A3-ve-parkinson-s-disease
#15
Marina Picillo, Gabriella Santangelo, Marcello Moccia, Roberto Erro, Marianna Amboni, Elio Prestipino, Katia Longo, Carmine Vitale, Emanuele Spina, Giuseppe Orefice, Paolo Barone, Maria Teresa Pellecchia
Both low serum uric acid (UA) levels and apathy are considered biomarkers of cognitive decline and dementia in Parkinson's disease (PD). There is an urgent need to combine different biomarkers to predict disease course in PD. Data on the relationship between serum UA levels and apathy in PD are lacking. The aim of this study is to evaluate the relationship between serum UA levels and pure apathy in early, drug-naïve PD patients. Forty-nine early, drug-naïve PD patients were enrolled and stratified into two groups using the median serum UA levels at diagnosis (Group 1 serum UA ≤ 4...
April 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/26671143/association-of-serum-uric-acid-level-with-cognitive-function-among-patients-with-multiple-system-atrophy
#16
Bei Cao, Qian-Qian Wei, Ruwei Ou, Jing Yang, Hui-Fang Shang
BACKGROUND AND OBJECTIVE: Oxidative stress is involved in the pathogenesis of multiple system atrophy (MSA) and cognitive impairment. Uric acid has an anti-oxidative effect. Our objective is to clarify the correlations between serum uric acid and cognitive function as well as frontal lobe function in Chinese MSA patients. METHODS: All of MSA patients were evaluated using Addenbrooke's Cognitive Examination-Revised (ACE-R), Frontal Assessment Battery (FAB), and Unified MSA Rating Scale (UMSARS)...
December 15, 2015: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/26217177/contra-directional-expression-of-serum-homocysteine-and-uric-acid-as-important-biomarkers-of-multiple-system-atrophy-severity-a-cross-sectional-study
#17
Dan Chen, Xiaobo Wei, Jing Zou, Rui Wang, Xu Liu, Xiaofeng Xu, Jianjun Lu, Zhanhang Wang, Beisha Tang, Brian Wang, Kunlin Jin, Qing Wang
HIGHLIGHTS: Serum Hcy was higher in MSA patients when compared to healthy subjects, particularly in male patients.Serum UA was lower in MSA patients when compared healthy subjects, particularly in male patients.Serum Hcy levels were significantly positively correlated with the severity of MSA.The ROC curve for the combination of Hcy and UA showed potential diagnostic value in discriminating MSA from healthy subjects. AIM: There is evidence suggesting that inflammatory responses play a critical role in the pathogenesis of multiple system atrophy (MSA)...
2015: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/25925000/lower-uric-acid-linked-with-cognitive-dysfunction-in-the-elderly
#18
Edna Méndez-Hernández, José Salas-Pacheco, Luis Ruano-Calderón, Alfredo Téllez-Valencia, Jorge Cisneros-Martínez, Marcelo Barraza-Salas, Oscar Arias-Carrión
Uric acid has been associated as a risk factor for cardiovascular disease. Recently, however, there is growing evidence that uric acid plays a role as antioxidant in the brain. In cognitive dysfunction, vascular and oxidative stress mechanisms play a role, but the link remains unknown. Therefore, we investigated the link between serum uric acid-levels and cognitive function in 62 elderly subjects. The statistical analysis was adjusted to age, sex and cardiovascular risk factors. Here, we found that lower serum uric acid levels are linked to cognitive dysfunction...
2015: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/25794156/serum-uric-acid-and-subsequent-cognitive-performance-in-patients-with-pre-existing-cardiovascular-disease
#19
MULTICENTER STUDY
Noa Molshatzki, Galit Weinstein, Jonathan Y Streifler, Uri Goldbourt, David Tanne
High serum uric acid (UA) levels are associated with numerous vascular risk factors, and vascular disease, that predispose patients to cognitive impairment, yet UA is also a major natural antioxidant and higher levels have been linked to slower progression of several neurodegenerative disease. In-order to test the association between UA and subsequent cognitive performance among patients that carry a high vascular burden, UA levels were determined by calorimetric enzymatic tests in a sub-cohort of patients with chronic cardiovascular disease who previously participating in a secondary prevention trial...
2015: PloS One
https://www.readbyqxmd.com/read/25451914/relationship-between-olfactory-dysfunction-and-cognitive-impairment-in-elderly-patients-with-type-2-diabetes-mellitus
#20
MULTICENTER STUDY
Haruna Sanke, Tomoya Mita, Hidenori Yoshii, Ayako Yokota, Keiko Yamashiro, Noriko Ingaki, Tomio Onuma, Yuki Someya, Koji Komiya, Yoshifumi Tamura, Tomoaki Shimizu, Chie Ohmura, Akio Kanazawa, Yoshio Fujitani, Hirotaka Watada
AIMS: Recent clinical studies identified the relation between olfactory dysfunction and cognitive impairment in the elderly without type 2 diabetes mellitus. The aim of the present study was to define the relation between olfactory function and cognition in elderly patients with type 2 diabetes mellitus. METHODS: The study participants comprised 250 elderly (age, 68-77, median 72) Japanese outpatient with type 2 diabetes mellitus free of clinically-evident cognitive impairment...
December 2014: Diabetes Research and Clinical Practice
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