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Inflamatory response

Marie Willems, Nadège Dubois, Lucia Musumeci, Vincent Bours, Pierre A Robe
IκBζ, an atypical member of the nuclear IκB family of proteins, is expressed at low levels in most resting cells, but is induced upon stimulation of Toll-like/IL-1 receptors through an IRAK1/IRAK4/NFκB-dependent pathway. Like its homolog Bcl3, IκBζ can regulate the transcription of a set of inflamatory genes through its association with the p50 or p52 subunits of NF-κB. Long studied as a key component of the immune response, IκBζ emerges as an important regulator of inflammation, cell proliferation and survival...
August 26, 2016: Oncotarget
Tugba Soydas, Ozcan Karaman, Hulya Arkan, Guven Yenmis, M Muzaffer Ilhan, Kubra Tombulturk, Ertugrul Tasan, Gonul Kanigur Sultuybek
Morbid obesity(MO) is associated with an increase in circulating levels of systemic acute phase proteins such as C-reactive protein (CRP).Toll-like reseptor is possible candidate for inflamatory responses which is mainly mediated by NFKB. The aim of this study was to investigate the relationship between NFKB1 and TLR-2 polymorphisms and the risk of MO in a Turkish population in the context of CRP serum levels which may contribute to susceptibility to the disease. We analyzed the distribution of NFKB1 -94ins/delATTG rs28362491 and TLR-2 Arg753Gly rs5743708 polymorphisms using PCR-RFLP method and CRP serum levels using ELISA method in 213 MO and 200 healthy controls...
August 10, 2016: Scandinavian Journal of Immunology
Jorge Valencia-Ortega, Arturo Zárate, Renata Saucedo, Hernández-Valencia Marcelino, José Gregorio Cruz-Durán, Edgardo Puello-Tamara, Fabián Arechavaleta-Velasco
Preeclampsia is one of the main causes of maternal and perinatal mortality in the world; however, the pathophysiologic pathways haven't been clearly elucidated. It is thought to result from a breakdown of maternal tolerance to paternal antigens in placenta that start an immune response against the trophoblast inducing a defective placentation and a hipoxic/isquemic environment which in turn triggers a systemic inflamatory response. This review gives an overview of the mechanims involved in maternal tolerance, how these are disrupted in preeclampsia, and how they contribute to the inflamatory response...
August 2015: Ginecología y Obstetricia de México
Nicole Steiner, Rachelle Balez, Niloo Karunaweera, Joanne M Lind, Gerald Münch, Lezanne Ooi
Chronic inflammation is a hallmark of neurodegenerative disease and cytotoxic levels of nitric oxide (NO) and pro-inflammatory cytokines can initiate neuronal death pathways. A range of cellular assays were used to assess the anti-inflammatory and neuroprotective action of resveratrol using murine microglial (C8-B4), macrophage (RAW264.7) and neuronal-like (Neuro2a) cell lines. We examined the release of NO by Griess assay and used a Bioplex array to measure a panel of pro- and anti-inflammatory cytokines and chemokines, in response to the inflammatory stimuli lipopolysaccharide (LPS) and interferon-γ (IFN-γ)...
May 2016: Neurochemistry International
A Martínez-Esteve, R M Álvarez-Pérez, R Núñez-Vázquez, J L Tirado-Hospital, R García-Jiménez, J Povedano-Gómez, I Borrego-Dorado
OBJECTIVE: To assess the outcome and adverse-effects of the radioisotope synoviorthesis in paediatric and adolescent patients with haemophilia. MATERIAL AND METHODS: Prospective study of historical cohort was conducted. A total of 20 consecutive haemophiliacs with a mean age of 13.1 years (range 4-17) were included with a mean follow-up of 64.9 months (range 18-109). The diagnosis of synovitis was established on the basis of clinical follow-up including radiological images (radiography and/or MRI)...
January 2016: Revista Española de Medicina Nuclear e Imagen Molecular
M Pavkovic, R Angelovic, M Popova-Simjanovska, O Karanfilski, S Trpkovska-Terzieva, T Sotirova, L Cevreska, A Stojanovic
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by thrombocytopenia due to platelet autoantibodies, causing an accelerated clearance of opsonized platelets by phagocytes. The etiology of ITP remains unclear, both genetic and environmental factors may have a role in the disease development. The aim of our study was to investigate a possible association of three single nucleotide polymorphisms (SNP) in the genes for interleukin beta (IL1B-511C/T), tumor necrosis factor beta (TNF+252G/A) and tumor necrosis factor alpha (TNFA-308G/A) with ITP...
2015: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
Yong-Tang Wang, Xiu-Min Lu, Kai-Ting Chen, Ya-Hai Shu, Chun-Hong Qiu
Regeneration in the central nervous system (CNS) of adult mammalian after traumatic injury is limited, which often causes permanent functional motor and sensory loss. After spinal cord injury (SCI), the lack of regeneration is mainly attributed to the presence of a hostile microenvironment, glial scarring, and cavitation. Besides, inflammation has also been proved to play a crucial role in secondary degeneration following SCI. The more prominent treatment strategies in experimental models focus mainly on drugs and cell therapies, however, only a few strategies applied in clinical studies and therapies still have only limited effects on the repair of SCI...
2015: Current Pharmaceutical Biotechnology
Jelena Cvetkovic, Natasa Ilic, Ljiljana Sofronic-Milosavljevic, Alisa Gruden-Movsesijan
Trichinella spiralis muscle larvae excretory-secretory antigens (ES L1) are most likely responsible for the induction of immune response during infection by this parasitic. The antigens bear carbohydrate structures that may contribute to immune system activation resulting in a Th2/anti-inflammatory immune response. We show that T. spiralis glycans affect the expression and the production of IL-4 and IL-10 in vivo. Alteration of carbohydrate structures on ES L1 altered dendritic cell (DC) maturation. Periodate treatment of ES L1 led to the reduction in both ERK and p38 phosphorylation which may be the cause of reduced IL-10 and IL-12p70 production...
December 2014: Comparative Immunology, Microbiology and Infectious Diseases
K Klíma, V Vaněček, A Kohout, O Jiroušek, R Foltán, J Štulík, V Machoň, G Pavlíková, P Jendelová, E Syková, J Šedý
Stem cells biology is one of the most frequent topic of physiological research of today. Spinal fusion represents common bone biology challenge. It is the indicator of osteoinduction and new bone formation on ectopic model. The purpose of this study was to establish a simple model of spinal fusion based on a rat model including verification of the possible use of titanium microplates with hydroxyapatite scaffold combined with human bone marrow-derived mesenchymal stem cells (MSCs). Spinous processes of two adjacent vertebrae were fixed in 15 Wistar rats...
2015: Physiological Research
Vahid Shaygannejad, Saeed Montazeri, Azam Jamshidian, Soheil Tahani, Marjan Gharagozloo, Fereshteh Ashtari, Sahar Vesal, Seyed Javad Hasheminia, Leila Dehghani
BACKGROUND: Midkine (MK) is a heparin-binding growth factor with promoting effects in inflammatory responses through enhancing leukocytes migration. OBJECTIVE: To study the correlation between MK serum levels and concentration of inflammatory cytokines in Multiple Sclerosis (MS) patients. METHODS: We evaluated the MK level and its relationship with inflammatory cytokines (IL-17 and IL-23) and anti-inflammatory ones (IL-10 and TGF-β) in multiple sclerosis (MS) patients...
June 2014: Iranian Journal of Immunology: IJI
Marcelo H Napimoga, Juliana T Clemente-Napimoga, Cristina G Macedo, Fabiana F Freitas, Rafael N Stipp, Felipe A Pinho-Ribeiro, Rubia Casagrande, Waldiceu A Verri
Periodontitis is a disease that leads to bone destruction and represents the main cause of tooth loss in adults. The development of aggressive periodontitis has been associated with increased inflammatory response that is induced by the presence of a subgingival biofilm containing Aggregatibacter actinomycetemcomitans. The flavonoid quercetin (1) is widespread in vegetables and fruits and exhibits many biological properties for possible medical and clinical applications such as its anti-inflamatory and antioxidant effects...
December 27, 2013: Journal of Natural Products
Thiago Gomes Romano, Paulo Fernando Guimarães Morando Marzocchi Tierno
Acute Kidney Injury (AKI) in trauma is, in most cases, multifactorial. Factors related to the initial ressuscitation protocol, degree of the systemic inflamatory response to trauma, contrast nephropathy in diagnostic procedures, rhabdomyolysis and abdominal compartment syndrome are some of those factors. Nowadays a uniformization in diagnostic criteria for AKI has been proposed by the Acute Kidney Injury Network (AKIN) and as a result the incidence of AKI and its impact in outcomes in trauma patients also needs to be reconsider...
January 2013: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Rajeev Sarmah
Dexamethasone (DEX) an anti-inflamatory 9-fluoro-glucocorticoid, activates the cytosolic glucocorticoid receptor (GR) binding to its Ligand Binding Domain (LBD). The GR-ligand complex then translocates to the nucleus and binds to the Glucocorticoid Response Element (GRE) resulting up-regulation of target gene expression of anti-inflamatory proteins. DEX is one of the most effective ligand for GR activation but comply to side effects. Therefore, alternative for DEX - plant metabolites of Calotropis sp and Swertia chirata were screened using docking appraoch...
2012: Bioinformation
Yaozhong Ding, Jiangnan Xu, Jonathan S Bromberg
CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells migrate into both inflammatory sites and draining lymph nodes (LNs) during an immune response, and have unique and overlaping functions in each location. Current studies suggest that Treg cells in draining LNs and inflamatory sites may not simply be a division of labor, but rather Treg cells migrate in a coordinated fashion between peripheral tissues and draining LNs. Trafficking between inflammatory sites and draining LNs is not only crucial for Treg cells to act, but also for them to acquire optimal immune regulatory activities...
April 2012: Trends in Immunology
Ivan Marjanović, Miodrag Jevtić, Sidor Misović, Danilo Vojvodić, Uros Zoranović, Sinisa Rusović, Momir Sarac, Ivan Stanojević
BACKGROUND/AIM: Abdominal aorta aneurysm (AAA) represents a pathological enlargment of infrarenal portion of aorta for over 50% of its lumen. The only treatment of AAA is a surgical reconstruction of the affected segment. Until the late XX century, surgical reconstruction implied explicit, open repair (OR) of AAA, which was accompanied by a significant morbidity and mortality of the treated patients. Development of endovascular repair of (EVAR) AAA, especially in the last decade, offered another possibility of surgical reconstruction of AAA...
November 2011: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
Horacio Rivera, Martha S Morales-Ríos, Wendy Bautista, Mineko Shibayama, Víctor Tsutsumi, Pablo Muriel, Víctor Pérez-Álvarez
There has been a recently increase in the development of novel stilbene-based compounds with in vitro anti-inflamatory properties. For this study, we synthesized and evaluated the anti-inflammatory properties of 2 fluorinated stilbenes on carbon tetrachloride (CCl₄)-induced acute liver damage. To achieve this, CCl₄ (4 g·kg(-1), per os) was administered to male Wistar rats, followed by either 2-fluoro-4'-methoxystilbene (FME) or 2,3-difluoro-4'-methoxystilbene (DFME) (10 mg·kg(-1), per os). We found that although both of the latter compounds prevented cholestatic damage (γ-glutamyl transpeptidase activity), only DFME showed partial but consistent results in the prevention of necrosis, as assessed by both alanine aminotransferase activity and histological analysis...
October 2011: Canadian Journal of Physiology and Pharmacology
Theodora Kafkia, Melissa Chamney, Anna Drinkwater, Marisa Pegoraro, John Sedgewick
Pain is an unpleasant sensory and emotional experience and is the most common symptom experienced by renal patients. It can be caused by primary co-morbid diseases, renal replacement therapies, medication or treatment side effects, and its intensity varies from moderate to severe. Pain management in renal patients is difficult, since the distance between pain relief and toxicity is very small. This paper will provide an algorithm for pain management proposed using paracetamol, nonsteroid anti-inflamatory drugs (NSAIDs), mild and stronger opioids as well as complementary techniques...
June 2011: Journal of Renal Care
Carolina Babosa Brito da Matta, Everton Tenório de Souza, Aline Cavalcanti de Queiroz, Daysianne Pereira de Lira, Morgana Vital de Araújo, Luiz Henrique Agra Cavalcante-Silva, George Emmanuel C de Miranda, João Xavier de Araújo-Júnior, José Maria Barbosa-Filho, Bárbara Viviana de Oliveira Santos, Magna Suzana Alexandre-Moreira
Marine natural products have been the focus of discovery for new products of chemical and pharmacological interest. The aim of this study was to evaluate the antinociceptive activity of the methanolic (ME), acetate (AE), hexanic (HE) and chloroform (CE) extracts obtained from Caulerpa mexicana, and ME, CE and HE obtained from Caulerpa sertularioides. These marine algae are found all over the world, mainly in tropical regions. Models such as the writhing test, the hot plate test and formalin-induced nociception test were used to evaluate antinociceptive activity in laboratory mice...
2011: Marine Drugs
Magdalena R Naylor, Shelly Naud, Francis J Keefe, John E Helzer
UNLABELLED: This paper examines whether a telephone-based, automated maintenance enhancement program can help to reduce opioid and nonsteroidal anti-inflamatory drugs (NSAID) analgesic use in patients with chronic pain. Following 11 weeks of group cognitive-behavioral therapy (CBT), 51 subjects with chronic musculoskeletal pain were randomized to 1 of 2 study groups. Twenty-six subjects participated in 4 months of a Therapeutic Interactive Voice Response (TIVR) program in addition to standard follow-up care, while a control group of 25 subjects received standard follow-up care only...
December 2010: Journal of Pain: Official Journal of the American Pain Society
Antonio Alcami, Margarida Saraiva
Chemokines are chemoattractant cytokines that play an important role in immunity. The role of chemokines against invading pathogens is emphasized by the expression of chemokine inhibitors by many pathogens. A mechanims employed by poxviruses and herpesviruses is the secretion of chemokine bindingproteins unrelated to host receptors that bind chemokines with high affinity and block their activity. Soluble chemokine binding proteins have also been identified in the human parasite Schistosoma mansoni and in ticks...
2009: Advances in Experimental Medicine and Biology
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