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https://www.readbyqxmd.com/read/26388133/human-igg-antinuclear-antibodies-induce-pregnancy-loss-in-mice-by-increasing-immune-complex-deposition-in-placental-tissue-in-vivo-study
#1
Manuela Veglia, Silvia D'Ippolito, Riccardo Marana, Fiorella Di Nicuolo, Roberta Castellani, Valentina Bruno, Alessia Fiorelli, Francesco Ria, Giuseppe Maulucci, Marco De Spirito, Giuseppe Migliara, Giovanni Scambia, Nicoletta Di Simone
PROBLEM: A threefold higher prevalence of antinuclear antibodies (ANA) has been reported in patients with recurrent pregnancy loss (RPL). Nevertheless, the role of ANA in reproductive failure is still unclear. The aim of this study was to investigate the role of ANA during early pregnancy in vivo. METHOD OF STUDY: We used pregnant mice treated with immunoglobulin G (IgG) obtained from normal healthy subjects (NHS); ANA(+) sera of patients with RPL; and ANA(+) sera from women with uncomplicated pregnancies (HW)...
December 2015: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/24864190/nitric-oxide-synthetic-pathway-in-patients-with-microvascular-angina-and-its-relations-with-oxidative-stress
#2
Benedetta Porro, Sonia Eligini, Fabrizio Veglia, Alessandro Lualdi, Isabella Squellerio, Susanna Fiorelli, Marta Giovannardi, Elisa Chiorino, Alessia Dalla Cia, Mauro Crisci, José Pablo Werba, Elena Tremoli, Viviana Cavalca
A decreased nitric oxide (NO) bioavailability and an increased oxidative stress play a pivotal role in different cardiovascular pathologies. As red blood cells (RBCs) participate in NO formation in the bloodstream, the aim of this study was to outline the metabolic profile of L-arginine (Arg)/NO pathway and of oxidative stress status in RBCs and in plasma of patients with microvascular angina (MVA), investigating similarities and differences with respect to coronary artery disease (CAD) patients or healthy controls (Ctrl)...
2014: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/16833049/which-model-of-stroke-unit-is-better-for-stroke-patient-management
#3
REVIEW
Svetlana Lorenzano, Alessia Anzini, Manuela de Michele, Anne Falcou, Silvia Fausti, Cristina Gori, Alessandra Mancini, Cristina Cavalletti, Carlo Colosimo, Marco Fiorelli, Maria Luisa Sacchetti, Corrado Argentino, Danilo Toni
The increasing prevalence of cerebrovascular diseases has made urgent the need to develop timely and effective treatment strategies to tackle this health problem. Stroke units (SUs) appear to be the ideal setting where the management of acute stroke patients, including specific treatments as thrombolysis, may be optimized. Which model of SU gives the best results is still an unsettled issue. The more intensive and timely multidisciplinary approach to the acute phase of stroke, the management of medical complications, and the earlier and more focused rehabilitation, are likely the most qualifying aspects of our Neurovascular treatment unit...
April 2006: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/16452397/pituitary-macroadenomas-preoperative-evaluation-of-consistency-with-diffusion-weighted-mr-imaging-initial-experience
#4
Alberto Pierallini, Francesca Caramia, Carlo Falcone, Emanuele Tinelli, Amalia Paonessa, Alessia Bernardo Ciddio, Marco Fiorelli, Federico Bianco, Stefania Natalizi, Luigi Ferrante, Luigi Bozzao
PURPOSE: To prospectively evaluate use of diffusion-weighted (DW) magnetic resonance (MR) images and apparent diffusion coefficient (ADC) maps for determination of the consistency of macroadenomas. MATERIALS AND METHODS: The study protocol was approved by the institutional ethics committee, and informed consent was obtained from all patients. Twenty-two patients with pituitary macroadenoma (10 men, 12 women; mean age, 54 years +/- 17.09 [standard deviation]; range, 21-75 years) were examined...
April 2006: Radiology
https://www.readbyqxmd.com/read/15947116/erbeta-is-a-potent-inhibitor-of-cell-proliferation-in-the-hct8-human-colon-cancer-cell-line-through-regulation-of-cell-cycle-components
#5
Valentina Martineti, Lucia Picariello, Isabella Tognarini, Silvia Carbonell Sala, Alessia Gozzini, Chiara Azzari, Carmelo Mavilia, Annalisa Tanini, Alberto Falchetti, Gianna Fiorelli, Francesco Tonelli, Maria Luisa Brandi
Several strands of evidence indicate that oestrogens exert a protective role against the development of colon cancer through indirect and direct effects on colonic epithelium. Oestrogen receptor beta (ERbeta), the predominant ER subtype in human colon, is significantly decreased in colonic tumours compared with normal mucosa suggesting a potential role in the regulation of colon tumour growth. To investigate this hypothesis we engineered human colon cancer ERalpha-negative HCT8 cells in order to obtain ERbeta protein over-expression...
June 2005: Endocrine-related Cancer
https://www.readbyqxmd.com/read/12667802/analysis-of-the-functional-relationship-between-v3-loop-and-gp120-context-with-regard-to-human-immunodeficiency-virus-coreceptor-usage-using-naturally-selected-sequences-and-different-viral-backbones
#6
Patrizia Bagnarelli, Lara Fiorelli, Manuela Vecchi, Alessia Monachetti, Stefano Menzo, Massimo Clementi
The human immunodeficiency virus type 1 (HIV-1) gp120 V3 loop plays a predominant role in chemokine receptor usage; however, other linear and nonlinear gp120 domains are involved in this step of the HIV-1 replication cycle. At present, the functional relationship between V3 and these domains with regard to coreceptor usage is unclear. To gain insights into the nature of this relationship in naturally selected viral variants, we developed a recombinant strategy based on two different gp120 backbones derived from CXCR4 (X4)- and CCR5 (R5)-tropic viral strains, respectively...
March 15, 2003: Virology
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