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https://www.readbyqxmd.com/read/29779157/3d-ct-of-renal-pathology-initial-experience-with-cinematic-rendering
#1
REVIEW
Steven P Rowe, Alexa R Meyer, Michael A Gorin, Pamela T Johnson, Elliot K Fishman
3D computed tomography (CT) visualizations of volumetric data have become an important aspect of diagnostic imaging. The utility of 3D CT has been well described for the imaging of a number of renal pathologies. Recently, a new 3D visualization technique known as cinematic rendering (CR) has become available and provides photorealistic images derived from standard CT acquisitions by use of a complex global lighting model. Herein, we describe a number of normal variant and pathologic conditions of the kidney visualized with CR...
May 19, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29774184/a-systematic-review-of-clinical-value-of-three-dimensional-printing-in-renal-disease
#2
Zhonghua Sun, Dongting Liu
The aim of this systematic review is to analyse current literature related to the clinical value of three-dimensional (3D) printed models in renal disease. A literature search of PubMed and Scopus databases was performed to identify studies reporting the clinical application and usefulness of 3D printed models in renal disease. Fifteen studies were found to meet the selection criteria and were included in the analysis. Eight of them provided quantitative assessments with five studies focusing on dimensional accuracy of 3D printed models in replicating renal anatomy and tumour, and on measuring tumour volume between 3D printed models and original source images and surgical specimens, with mean difference less than 10%...
April 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29769543/the-cytokine-secretion-profile-of-mesenchymal-stromal-cells-is-determined-by-surface-structure-of-the-microenvironment
#3
Daniëlle G Leuning, Nick R M Beijer, Nadia A du Fossé, Steven Vermeulen, Ellen Lievers, Cees van Kooten, Ton J Rabelink, Jan de Boer
Mesenchymal stromal cells (MSC) secrete factors that contribute to organ homeostasis and repair in a tissue specific manner. For instance, kidney perivascular mesenchymal stromal cells (kPSCs) can facilitate renal epithelial repair through secretion of hepatocyte growth factor (HGF) while the secretome of bone marrow MSCs gives rise to immunosuppression. Stromal cells function in a complex 3-dimensional (3D) connective tissue architecture that induces conformational adaptation. Here we tested the hypothesis that surface topography and associated cell adaptations dictate stromal cell function through tuning of the cytokines released...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29761690/assessment-of-the-relationship-between-renal-volume-and-renal-function-after-minimally-invasive-partial-nephrectomy-the-role-of-computed-tomography-and-nuclear-renal-scan
#4
Riccardo Bertolo, Cristian Fiori, Federico Piramide, Daniele Amparore, Monica Barrera, Diego Sardo, Andrea Veltri, Francesco Porpiglia
BACKGROUND: To evaluate the correlation between the loss of renal function as assessed by Tc99MAG-3 renal scan and the loss of renal volume as calculated by volumetric assessment on CT-scan in patients who underwent minimally-invasive partial nephrectomy (PN). METHODS: PN prospectively-maintained database was retrospectively queried for patients who underwent minimally-invasive PN (2012-2017) for renal mass <cT2 and had complete data on renal scan and contrast-enhanced CT-scan (both performed in our Institution) both at preoperative assessment and at the third postoperative month follow-up...
May 14, 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29744824/usefulness-of-personalized-three-dimensional-printed-model-on-the-satisfaction-of-preoperative-education-for-patients-undergoing-robot-assisted-partial-nephrectomy-and-their-families
#5
Jun Teishima, Yukihiro Takayama, Shogo Iwaguro, Tetsutaro Hayashi, Shogo Inoue, Keisuke Hieda, Shunsuke Shinmei, Ryoji Kato, Koji Mita, Akio Matsubara
OBJECTIVE: To clarify the usefulness of a personalized three-dimensional (3D) printed model of the kidney for preoperative education among patients who underwent robot-assisted partial nephrectomy (RAPN). METHODS: Twenty-nine cases of patients who planned to undergo RAPN and 19 of their families participated in this study. A three-dimensional model consisting of the kidney, tumors, ureter, inferior vena cava, and abdominal aorta in each case was generated using a Z Printer 450 based on the findings of preoperative enhanced CT...
May 9, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29744639/drug-transporter-expression-profiling-in-a-three-dimensional-kidney-proximal-tubule-in-vitro-nephrotoxicity-model
#6
Dorina Diekjürgen, David W Grainger
Given currently poor toxicity translational predictions for drug candidates, improved mechanistic understanding underlying nephrotoxicity and drug renal clearance is needed to improve drug development and safety screening. Therefore, better relevant and well-characterized in vitro screening models are required to reliably predict human nephrotoxicity. Because kidney proximal tubules are central to active drug uptake and secretion processes and therefore to nephrotoxicity, this study acquired regio-specific expression data from recently reported primary proximal tubule three-dimensional (3D) hyaluronic acid gel culture and non-gel embedded cultured murine proximal tubule suspensions used in nephrotoxicity assays...
May 9, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29721067/3d-imaging-and-quantitative-analysis-of-vascular-networks-a-comparison-of-ultramicroscopy-and-micro-computed-tomography
#7
Jeremy Epah, Katalin Pálfi, Franziska Luise Dienst, Pedro Felipe Malacarne, Rolf Bremer, Michael Salamon, Sandeep Kumar, Hanjoong Jo, Christoph Schürmann, Ralf Peter Brandes
RATIONALE: Classic histology is the gold standard for vascular network imaging and analysis. The method however is laborious and prone to artefacts. Here, the suitability of ultramicroscopy (UM) and micro-computed tomography (CT) was studied to establish potential alternatives to histology. METHODS: The vasculature of murine organs (kidney, heart and atherosclerotic carotid arteries) was visualized using conventional 2D microscopy, 3D light sheet ultramicroscopy (UM) and micro-CT...
2018: Theranostics
https://www.readbyqxmd.com/read/29693448/three-dimensional-in-vitro-models-answer-the-right-questions-in-adpkd-cystogenesis
#8
Eryn E Dixon, Owen M Woodward
Novel technologies, new understanding of the basement membrane composition, and better comprehension of the embryonic development of the mammalian kidney have led to explosive growth in the use of three dimensional (3D) in vitro models to study a range of human disease pathologies(6, 35). The development of these effective model systems represents a new tool to study the progressive cystogenesis of autosomal dominant polycystic kidney disease (ADPKD). ADPKD is a prevalent and complex monogenetic disease, characterized by the pathological formation of fluid fill cysts in renal tissue(17, 40)...
April 25, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29682611/unilateral-renal-tumor-cryoablation-and-contralateral-radical-nephrectomy-of-bilateral-renal-tumors-by-transumbilical-3d-multichannel-laparoendoscopic-single-site-surgery
#9
Guopeng Yu, Ke Zhang, Wenzhi Li, Long Li, Yanliang Zhao, Yiwei Wang, Mingxi Xu, Jun Da, Guoqin Dong, Zhong Wang, Bin Xu
Background: Unilateral renal tumor cryoablation and contralateral radical nephrectomy of bilateral renal tumors were performed by transumbilical three-dimensional (3D) multichannel laparoendoscopic single-site (LESS) surgery, in an attempt to verify the feasibility and safety of the procedure, sum up the operational experience, and evaluate the surgical outcome. Case Presentation: This was a 47-year-old female patient with a body mass index of 27.34 kg/m2 without backache, low back pain, hematuria, urinary urgency, frequent urination, dysuria, and other symptoms...
2018: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/29673945/three-dimensional-texture-analysis-with-machine-learning-provides-incremental-predictive-information-for-successful-shock-wave-lithotripsy-in-patients-with-kidney-stones
#10
Manoj Mannil, Jochen von Spiczak, Thomas Hermanns, Cédric Poyet, Hatem Alkadhi, Christian Daniel Fankhauser
PURPOSE: To determine the predictive value of three-dimensional texture analysis (3D-TA) in computed tomography (CT) images for successful shock wave lithotripsy (SWL) in patients with kidney stones. MATERIAL AND METHODS: Patients with pre and postoperative CT scans, previously untreated kidney stones and a stone diameter of 5-20 mm were included. A total of 224 3D-TA features of each kidney stone, including the attenuation measured in Hounsfield Units (HU), and the clinical variables body mass index (BMI), initial stone size, and skin-to-stone distance (SSD) were analyzed using five commonly used machine learning models...
April 16, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29673177/the-hippo-yap-pathway-regulates-3d-organ-formation-and-homeostasis
#11
Erika Ishihara, Hiroshi Nishina
The vertebrate body shape is formed by the specific sizes and shapes of its resident tissues and organs, whose alignments are essential for proper functioning. To maintain tissue and organ shape, and thereby function, it is necessary to remove senescent, transformed, and/or damaged cells, which impair function and can lead to tumorigenesis. However, the molecular mechanisms underlying three-dimensional (3D) organ formation and homeostasis are not fully clear. Yes-associated protein (YAP) is a transcriptional co-activator that is involved in organ size control and tumorigenesis...
April 17, 2018: Cancers
https://www.readbyqxmd.com/read/29663419/accelerated-3d-bssfp-imaging-for-treatment-planning-on-an-mri-guided-radiotherapy-system
#12
Yu Gao, Ziwu Zhou, Fei Han, Minsong Cao, Narek Shaverdian, John V Hegde, Biraj B Bista, Michael Steinberg, Percy Lee, Ann Raldow, Daniel A Low, Yingli Yang, Peng Hu
PURPOSE: To introduce a compressed sensing and parallel imaging combined technique to reduce the acquisition time of planning MRI for MR-guided radiotherapy (MRgRT) systems. METHODS AND MATERIALS: A variable-density Poisson-Disk (VDPD) under-sampling acquisition along with compressed sensing reconstruction technique was developed and compared with the current planning MR protocol, which uses an optimized balanced-steady-state-free-precession sequence with 7.5-fold (7...
April 16, 2018: Medical Physics
https://www.readbyqxmd.com/read/29658563/preclinical-evaluation-of-a-novel-engineered-recombinant-human-anti-cd44v6-antibody-for-potential-use-in-radio-immunotherapy
#13
Anja C Mortensen, Diana Spiegelberg, Anna-Karin Haylock, Hans Lundqvist, Marika Nestor
CD44v6 is overexpressed in a variety of cancers, rendering it a promising target for radio-immunotherapy (RIT). In this study, we have characterized a novel engineered recombinant monoclonal anti-CD44v6 antibody, AbN44v6, and assessed its potential for use in RIT using either 177Lu or 131I as therapeutic radionuclides. In vitro affinity and specificity assays characterized the binding of the antibody labeled with 177Lu, 125I or 131I. The therapeutic effects of 177Lu-AbN44v6 and 131I-AbN44v6 were investigated using two in vitro 3D tumor models with different CD44v6 expression...
April 11, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29658431/in-silico-identification-and-screening-of-cyp24a1-inhibitors-3d-qsar-pharmacophore-mapping-and-molecular-dynamics-analysis
#14
Jayaraj John Marshal, Gopinath Krishnasamy, Jung-Kul Lee, Karthikeyan Muthusamy
Vitamin D is a key signalling molecule that plays a vital role in the regulation of calcium-phosphate homeostasis and bone remodelling. The circulating biologically active form of vitamin D is regulated by the catabolic mechanism of cytochrome P450 24-hydroxylase (CYP24A1) enzyme. The over-expression of CYP24A1 negatively regulates the vitamin D level, which is the causative agent of chronic kidney disease, osteoporosis, and several types of cancers. In this study, we found three potential lead molecules adverse to CYP24A1 through structure-based, atom-based pharmacophore and e-pharmacophore-based screening methods...
April 16, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29650317/monte-carlo-based-assessment-of-magic-magicaug-pagatug-and-pagataug-polymer-gel-dosimeters-for-ovaries-and-uterus-organ-dosimetry-in-brachytherapy-nuclear-medicine-and-tele-therapy
#15
Karim Adinehvand, Fereidoun Nowshiravan Rahatabad
BACKGROUND AND OBJECTIVES: Calculation of 3D dose distribution during radiotherapy and nuclear medicine helps us for better treatment of sensitive organs such as ovaries and uterus. In this research, we investigate two groups of normoxic dosimeters based on meta-acrylic acid (MAGIC and MAGICAUG) and polyacrylamide (PAGATUG and PAGATAUG) for brachytherapy, nuclear medicine and Tele-therapy in their sensitive and critical role as organ dosimeters. METHODS: These polymer gel dosimeters are compared with soft tissue while irradiated by different energy photons in therapeutic applications...
June 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29626256/dual-layer-spectral-detector-ct-non-inferiority-assessment-compared-to-dual-source-dual-energy-ct-in-discriminating-uric-acid-from-non-uric-acid-renal-stones-ex-vivo
#16
Lakshmi Ananthakrishnan, Xinhui Duan, Yin Xi, Matthew A Lewis, Margaret S Pearle, Jodi A Antonelli, Harold Goerne, Elysha M Kolitz, Suhny Abbara, Robert E Lenkinski, Julia R Fielding, John R Leyendecker
PURPOSE: To assess the non-inferiority of dual-layer spectral detector CT (SDCT) compared to dual-source dual-energy CT (dsDECT) in discriminating uric acid (UA) from non-UA stones. METHODS: Fifty-seven extracted urinary calculi were placed in a cylindrical phantom in a water bath and scanned on a SDCT scanner (IQon, Philips Healthcare) and second- and third-generation dsDECT scanners (Somatom Flash and Force, Siemens Healthcare) under matched scan parameters. For SDCT data, conventional images and virtual monoenergetic reconstructions were created...
April 7, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29609122/microwave-assisted-one-pot-synthesis-of-new-phenanthrene-fused-tetrahydrodibenzo-acridinones-as-potential-cytotoxic-and-apoptosis-inducing-agents
#17
Niggula Praveen Kumar, Pankaj Sharma, T Srinivasa Reddy, Nagula Shankaraiah, Suresh K Bhargava, Ahmed Kamal
An expeditious microwave-assisted one-pot synthesis of new cytotoxic phenanthrene fused-tetrahydrodibenzo-acridinones has been successfully accomplished. This protocol offers wide substrate scope, catalyst-free synthesis, atom-economy, simple recrystallization, high yields, and ethanol was used as green solvent. These new compounds were tested for their in vitro cytotoxicity against cervical (HeLa), prostate (PC-3), fibrosarcoma (HT-1080), ovarian (SKOV-3) cancer cells, and were safer to normal (Hek-293T) kidney cell line...
March 27, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29596080/low-dose-characterization-of-kidney-stones-using-spectral-detector-computed-tomography-an-ex-vivo-study
#18
Nils Große Hokamp, Johannes Salem, Albrecht Hesse, Jasmin Alexandra Holz, Manuel Ritter, Axel Heidenreich, David Maintz, Stefan Haneder
OBJECTIVES: The aim of this study was to investigate the feasibility of kidney stone composition analysis using spectral detector computed tomography scanner (SDCT) with normal- and low-dose imaging protocols. METHODS: A total of 154 stones harvested from nephrolithotripsy or nephrolithotomy with a known monocrystalline composition as determined by infrared spectroscopy were examined in a nonanthropomorphic phantom on an SDCT (IQon, Philips, Best, the Netherlands)...
March 28, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29578191/unenhanced-renal-magnetic-resonance-angiography-in-patients-with-chronic-kidney-disease-suspected-renovascular-hypertension-can-it-affect-patient-management
#19
J Yamuna, Anupama Chandrasekharan, Rajeswaran Rangasami, S Ramalakshmi, Santhosh Joseph
Background & objectives: Renal artery stenosis (RAS) is an important cause of severe hypertension in patients with chronic kidney disease (CKD). It is important to detect RAS early as it can reverse hypertension and stop rapid deterioration of renal function. The potential drawbacks of various imaging modalities used to detect RAS including contrast-related adverse effects associated with diagnostic angiography have led to increasing interest in unenhanced magnetic resonance (MR) renal angiography...
November 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29571154/postmortem-interval-estimation-using-the-animal-model-of-postmortem-gas-volume-changes
#20
Chika Iwamoto, Kenoki Ohuchida, Miki Okumura, Yosuke Usumoto, Junji Kishimoto, Masaharu Murata, Noriaki Ikeda, Makoto Hashizume
It is important to estimate the postmortem interval in forensic autopsy. Many methods to estimate the postmortem interval have been reported, and are typically associated with internal examination. However, there are issues such as rejection of autopsy by the family and a lack of forensic doctor in internal examination. Therefore, it is necessary to develop new methods, such as autopsy imaging, that can substitute for internal examination. Here, we first evaluated whether gas volume in the body increased with postmortem interval...
December 20, 2017: Legal Medicine
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