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https://www.readbyqxmd.com/read/28104741/recombinant-human-thyroid-stimulating-hormone-versus-thyroid-hormone-withdrawal-in-124i-pet-ct-based-dosimetry-for-131i-therapy-of-metastatic-differentiated-thyroid-cancer
#1
Donika Plyku, Robert F Hobbs, Kevin Huang, Frank Atkins, Carlos Garcia, George Sgouros, Douglas Van Nostrand
PURPOSE: Patients with metastatic differentiated thyroid cancer (DTC) may be prepared using either thyroid stimulating hormone withdrawal (THW) or recombinant human thyroid-stimulating hormone (rhTSH) injections prior to (131)I administration for treatment. The objective of this study was to compare the absorbed dose (D) to the critical organs and tumors determined by (124)I-Positron Emission Tomography/Computed Tomography (PET/CT) based dosimetry for (131)I therapy of metastatic DTC when the same patient was prepared with and imaged after both THW and rhTSH injections...
January 19, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28090431/a-role-for-3d-printing-in-kidney-on-a-chip-platforms
#2
Ryan D Sochol, Navin R Gupta, Joseph V Bonventre
The advancement of "kidney-on-a-chip" platforms - submillimeter-scale fluidic systems designed to recapitulate renal functions in vitro - directly impacts a wide range of biomedical fields, including drug screening, cell and tissue engineering, toxicity testing, and disease modelling. To fabricate kidney-on-a-chip technologies, researchers have primarily adapted traditional micromachining techniques that are rooted in the integrated circuit industry; hence the term, "chip." A significant challenge, however, is that such methods are inherently monolithic, which limits one's ability to accurately recreate the geometric and architectural complexity of the kidney in vivo...
March 2016: Current Transplantation Reports
https://www.readbyqxmd.com/read/28077268/development-of-high-resolution-3d-hyperpolarized-carbon-13-mr-molecular-imaging-techniques
#3
Eugene Milshteyn, Cornelius von Morze, Galen D Reed, Hong Shang, Peter J Shin, Zihan Zhu, Hsin-Yu Chen, Robert Bok, Andrei Goga, John Kurhanewicz, Peder E Z Larson, Daniel B Vigneron
The goal of this project was to develop and apply techniques for T2 mapping and 3D high resolution (1.5mm isotropic; 0.003cm(3)) (13)C imaging of hyperpolarized (HP) probes [1-(13)C]lactate, [1-(13)C]pyruvate, [2-(13)C]pyruvate, and [(13)C,(15)N2]urea in vivo. A specialized 2D bSSFP sequence was implemented on a clinical 3T scanner and used to obtain the first high resolution T2 maps of these different hyperpolarized compounds in both rats and tumor-bearing mice. These maps were first used to optimize timings for highest SNR for single time-point 3D bSSFP acquisitions with a 1...
January 7, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28073200/the-role-of-intraoperative-ultrasound-in-small-renal-mass-robotic-enucleation
#4
Roberta Gunelli, Massimo Fiori, Cristiano Salaris, Umberto Salomone, Marco Urbinati, Alexia Vici, Teo Zenico, Mauro Bertocco
INTRODUCTION: As a result of the growing evidence on tumor radical resection in literature, simple enucleation has become one of the best techniques associated to robotic surgery in the treatment of renal neoplasia, as it guarantees minimal invasiveness and the maximum sparing of renal tissue, facilitating the use of reduced or zero ischemia techniques during resection. The use of a robotic ultrasound probe represents a useful tool to detect and define tumor location, especially in poorly exophytic small renal mass...
December 30, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28062895/3d-printed-renal-cancer-models-derived-from-mri-data-application-in-pre-surgical-planning
#5
Nicole Wake, Temitope Rude, Stella K Kang, Michael D Stifelman, James F Borin, Daniel K Sodickson, William C Huang, Hersh Chandarana
OBJECTIVE: To determine whether patient-specific 3D printed renal tumor models change pre-operative planning decisions made by urological surgeons in preparation for complex renal mass surgical procedures. MATERIALS AND METHODS: From our ongoing IRB approved study on renal neoplasms, ten renal mass cases were retrospectively selected based on Nephrometry Score greater than 5 (range 6-10). A 3D post-contrast fat-suppressed gradient-echo T1-weighted sequence was used to generate 3D printed models...
January 7, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28061038/laparoscopic-partial-nephrectomy-supported-by-training-involving-personalized-silicone-replica-poured-in-three-dimensional-printed-casting-mold
#6
Adam Golab, Tomasz Smektala, Krystian Kaczmarek, Remigiusz Stamirowski, Michal Hrab, Marcin Slojewski
BACKGROUND: Most kidney neoplasms are found incidentally and qualify for nephron-sparing surgery. Laparoscopic approach is beneficial to these patients because of its minimally invasive approach. However, these operations are both difficult and require plenty of experience and extended training. Some stages of the operation are limited by permissible time of transient ischemia. We applied three-dimensional (3D) printing technology to create individual silicone models of kidney to be used for training in laparoscopic procedures before the actual surgeries...
January 6, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28060793/preterm-birth-and-ventilation-decrease-surface-density-of-glomerular-capillaries-in-lambs-regardless-of-postnatal-respiratory-support-mode
#7
Eveline Staub, Mar Janna Dahl, Calan Yost, Sydney Bowen, Toshio Aoki, Adam Blair, Zhengming Wang, Donald M Null, Bradley A Yoder, Kurt H Albertine
BACKGROUND: Prematurity is often complicated by respiratory support, including invasive mechanical ventilation (IMV) and non-invasive support (NIS). Compared to IMV, NIS reduces injury to the lung and brain. Prematurity may also disrupt glomerular architecture. Whether NIS differentially affects glomerular architecture is incompletely understood. We hypothesized that IMV would lead to greater disruption of glomerular architecture than NIS. METHODS: This is a secondary analysis of kidneys from moderately preterm lambs delivered at ~131d gestation (term ~150d) that had antenatal steroid exposure and surfactant treatment before resuscitation by IMV...
January 6, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28052872/fgfr2-is-integral-for-bladder-mesenchyme-patterning-and-function
#8
Youko Ikeda, Irina Zabbarova, Caitlin M Schaefer, Daniel S Bushnell, William C de Groat, Anthony J Kanai, Carlton M Bates
BACKGROUND: While urothelial signals, including sonic hedgehog (Shh), drive bladder mesenchyme differentiation, it is unclear which pathways within the mesenchyme are critical for its development. Studies have shown fibroblast growth factor receptor 2 (Fgfr2) is necessary for kidney and ureter mesenchymal development. OBJECTIVE: Out objective was to determine the role of Fgfr2 in bladder mesenchyme. METHODS: We used Tbx18cre mice to delete Fgfr2 in bladder mesenchyme (Fgfr2BM-/-)...
January 4, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28048921/su-f-j-127-multi-institutional-evaluation-of-setup-organ-deformation-precision-dosimetry-in-total-marrow-irradiation
#9
D Zuro, S Hui
PURPOSE: Totals Marrow Irradiation (TMI) is a highly focused radiation delivery to the human skeleton structure therefore requiring a high amount of precision and accuracy for a quality treatment. Not much is known on how the patient position varies across multiple treatment fractions and how that positioning impacts the dose delivery. Currently TMI is studied as an international collaboration with multiple centers around the world; however, many of these centers used different pretreatment techniques...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048039/su-f-i-74-dose-evaluation-based-on-monte-carlo-simulation-of-three-dimensional-rotational-angiography-during-hepatic-transarterial-chemoembolization-procedures
#10
Y Hwang, K Lui, Y Lin, H Tsai
PURPOSE: This study was aimed to investigate the dose with patient performing three-dimensional (3D) angiography imaging during hepatic transarterial chemoembolization (TACE) procedures. METHODS: Organ doses and effective doses calculations were retrospectively performed in 88 patients (61 males and 27 females with averaged age of 65.4±12.6 years old) referred for hepatic TACE on a digital flat-panel angiography system (Bransist safire; Shimadzu) using software (PCXMC; Helsinki, Finland) based on Monte Carlo technique...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047951/tu-h-campus-tep1-04-novel-3d-printed-plastic-cutouts-filled-with-aluminum-oxide-for-same-day-electron-radiotherapy
#11
J Mikell, C Lee, K Lam
PURPOSE: Clinics that outsource electron cutout manufacturing may be unable to simulate and treat patients on the same day. To enable same day treatment, we investigate the use of 3D printed hollow cutouts filled with 30 grit Al2 O3 powder. We verified the dosimetric equivalence of such a cutout relative to an outsourced Copper cutout. METHODS: Printing was performed using a Ultibots Kossel 250 V-Slot 3D printer and polylactic acid filament. Printing files were derived from an in-house 3D model designed to mate with a Varian 6 cm electron cone...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047839/th-cd-206-08-an-anthropopathic-deformable-phantom-for-geometric-and-dose-accumulation-accuracy-validation-of-deformable-image-registration
#12
Y Liao, H Chen, J Chen, X Gu, X Zhen, L Zhou
PURPOSE: To design and construct a three-dimensional (3D) anthropopathic abdominal phantom for evaluating deformable image registration (DIR) accuracy on images and dose deformation in adaptive radiation therapy (ART). METHOD: Organ moulds, including liver, kidney, spleen, stomach, vertebra and two metastasis tumors, are 3D printed using the contours from an ovarian cancer patient. The organ moulds are molded with deformable gels that made of different mixtures of polyvinyl chloride (PVC) and the softener dioctyl terephthalate...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047598/su-f-j-158-respiratory-motion-resolved-self-gated-4d-mri-using-rotating-cartesian-k-space-sampling
#13
F Han, Z Zhou, Y Yang, K Sheng, P Hu
PURPOSE: Dynamic MRI has been used to quantify respiratory motion of abdominal organs in radiation treatment planning. Many existing 4D-MRI methods based on 2D acquisitions suffer from limited slice resolution and additional stitching artifacts when evaluated in 3D(1) . To address these issues, we developed a 4D-MRI (3D dynamic) technique with true 3D k-space encoding and respiratory motion self-gating. METHODS: The 3D k-space was acquired using a Rotating Cartesian K-space (ROCK) pattern, where the Cartesian grid was reordered in a quasi-spiral fashion with each spiral arm rotated using golden angle(2) ...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047024/su-d-207a-07-the-effects-of-inter-cycle-respiratory-motion-variation-on-dose-accumulation-in-single-fraction-mr-guided-sbrt-treatment-of-renal-cell-carcinoma
#14
B Stemkens, M Glitzner, C Kontaxis, B Denis de Senneville, F Prins, Spm Crijns, L Kerkmeijer, J Lagendijk, Cat van den Berg, Rhn Tijssen
PURPOSE: To assess the dose deposition in simulated single-fraction MR-Linac treatments of renal cell carcinoma, when inter-cycle respiratory motion variation is taken into account using online MRI. METHODS: Three motion characterization methods, with increasing complexity, were compared to evaluate the effect of inter-cycle motion variation and drifts on the accumulated dose for an SBRT kidney MR-Linac treatment: 1) STATIC, in which static anatomy was assumed, 2) AVG-RESP, in which 4D-MRI phase-volumes were time-weighted, based on the respiratory phase and 3) PCA, in which 3D volumes were generated using a PCA-model, enabling the detection of inter-cycle variations and drifts...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28009506/earthicle-the-design-of-a-conceptually-new-type-of-particle
#15
Vuk Uskoković, Sebastian Pernal, Victoria M Wu
The conception and the steps made in the design of a conceptually new type of composite particle, so-called "earthicle", are being described. This particle is meant to roughly mimic the layered structure of the Earth, having zerovalent iron core, silicate mantle, and a thin carbonaceous crust resembling the biosphere and its geological remnants. Particles are made in a stable colloidal form in an aqueous medium, involving chemical precipitation and pyrolysis of citric acid in the solution. The effects of various synthesis parameters were studied, including borohydride and oleate concentrations, APTES/TEOS molar ratio, chemical nature of the carbon precursors, and others...
January 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27995752/ultrasound-image-based-visual-servoing-for-moving-target-ablation-by-high-intensity-focused-ultrasound
#16
Joonho Seo, Norihiro Koizumi, Mamoru Mitsuishi, Naohiko Sugita
BACKGROUND: Although high intensity focused ultrasound (HIFU) is a promising technology for tumor treatment, a moving abdominal target is still a challenge in current HIFU systems. In particular, respiratory-induced organ motion can reduce the treatment efficiency and negatively influence the treatment result. In this research, we present: (1) a methodology for integration of ultrasound (US) image based visual servoing in a HIFU system; and (2) the experimental results obtained using the developed system...
December 20, 2016: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/27994919/frequency-of-nerve-root-sleeve-cysts-in-autosomal-dominant-polycystic-kidney-disease
#17
Murat Aşık, Fatih Tufan, Timur Selçuk Akpınar, Nilgül Akalın, Elvan Ceyhan, Necmeddin Tunç, Zehra Işık Hasıloğlu, Mehmet Rıza Altıparmak, Tevfik Ecder, Sait Albayram
BACKGROUND: There is sporadic data about the occurrence of spinal meningeal cysts in patients with autosomal dominant polycystic kidney disease (ADPKD). We suggest that there is a relationship with the frequency and size of spinal meningeal cysts and headache, intracranial aneurysms, and cerebrospinal fluid leakage in patients with ADPKD. AIM: To investigate the relationship with spinal meningeal cyst, cerebrospinal fluid leakage, and headache in patients with ADPKD...
November 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27990487/tuning-hydrogel-properties-to-promote-the-assembly-of-salivary-gland-spheroids-in-3d
#18
Tugba Ozdemir, Eric W Fowler, Shuang Liu, Daniel A Harrington, Robert L Witt, Mary C Farach-Carson, Swati Pradhan-Bhatt, Xinqiao Jia
Current treatments for chronic xerostomia, or "dry mouth", do not offer long-term therapeutic benefits for head and neck cancer survivors previously treated with curative radiation. Towards the goal of creating tissue-engineered constructs for the restoration of salivary gland functions, we developed new hyaluronic acid (HA)-based hydrogels using thiolated HA (HA-SH) and acrylated HA (HA-AES) with a significant molecular weight mismatch. Four hydrogel formulations with varying HA concentration, (1-2.4 wt%) and thiol/acrylate ratios (2/1 to 36/1) and elastic moduli (G': 35 to 1897 Pa, 2 h post-mixing) were investigated...
December 12, 2016: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/27982133/identifying-ultrasensitive-hgf-dose-response-functions-in-a-3d-mammalian-system-for-synthetic-morphogenesis
#19
Vivek Raj Senthivel, Marc Sturrock, Gabriel Piedrafita, Mark Isalan
Nonlinear responses to signals are widespread natural phenomena that affect various cellular processes. Nonlinearity can be a desirable characteristic for engineering living organisms because it can lead to more switch-like responses, similar to those underlying the wiring in electronics. Steeper functions are described as ultrasensitive, and can be applied in synthetic biology by using various techniques including receptor decoys, multiple co-operative binding sites, and sequential positive feedbacks. Here, we explore the inherent non-linearity of a biological signaling system to identify functions that can potentially be exploited using cell genome engineering...
December 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27982115/generation-of-kidney-tubular-organoids-from-human-pluripotent-stem-cells
#20
Shintaro Yamaguchi, Ryuji Morizane, Koichiro Homma, Toshiaki Monkawa, Sayuri Suzuki, Shizuka Fujii, Muneaki Koda, Ken Hiratsuka, Maho Yamashita, Tadashi Yoshida, Shu Wakino, Koichi Hayashi, Junichi Sasaki, Shingo Hori, Hiroshi Itoh
Recent advances in stem cell research have resulted in methods to generate kidney organoids from human pluripotent stem cells (hPSCs), which contain cells of multiple lineages including nephron epithelial cells. Methods to purify specific types of cells from differentiated hPSCs, however, have not been established well. For bioengineering, cell transplantation, and disease modeling, it would be useful to establish those methods to obtain pure populations of specific types of kidney cells. Here, we report a simple two-step differentiation protocol to generate kidney tubular organoids from hPSCs with direct purification of KSP (kidney specific protein)-positive cells using anti-KSP antibody...
December 16, 2016: Scientific Reports
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