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https://www.readbyqxmd.com/read/29162088/prevention-of-glucocorticoid-associated-osteonecrosis-by-intravenous-administration-of-mesenchymal-stem-cells-in-a-rabbit-model
#1
Shusuke Ueda, Miyako Shimasaki, Toru Ichiseki, Yoshimichi Ueda, Masanobu Tsuchiya, Ayumi Kaneuji, Norio Kawahara
BACKGROUND: Glucocorticoid-associated osteonecrosis is an intractable condition, making the establishment of preventative strategies of particular importance. Recently various studies using mesenchymal stem cells (MSC) have been conducted. Using a rabbit glucocorticoid-associated osteonecrosis model we administered green fluorescent protein (GFP)-labeled MSC intravenously to investigate their effect on osteonecrosis. METHODS: A rabbit osteonecrosis model in which methylprednisolone (MP) 20 mg/kg was injected into the gluteus of a Japanese white rabbit was used...
November 21, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29160086/anatomic-and-radiologic-study-of-renal-avascular-plane-brodel-s-line-and-its-potential-relevance-on-percutaneous-and-surgical-approaches-to-the-kidney
#2
Veronica Macchi, Edgardo Picardi, Antonino Inferrera, Andrea Porzionato, Alessandro Crestani, Giacomo Novara, Raffaele De Caro, Vincenzo Ficarra
OBJECTIVE: The aim of the present anatomic and radiologic study was to evaluate the location, extension and characteristics of the Brödel's plane and eventually define its different patterns. MATERIAL AND METHODS: We evaluated 15 human normal kidneys sampled from un-embalmed cadavers without clinical history or anatomical evidence of renal diseases. Kidneys with the surrounding perirenal fat tissue were removed en bloc with the abdominal segment of the aorta. The renal artery was injected with acrylic and radiopaque resins...
November 21, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29156055/analysis-of-an-adtkd-family-with-a-novel-frameshift-mutation-in-muc1-reveals-characteristic-features-of-mutant-muc1-protein
#3
Satoko Yamamoto, Jun-Ya Kaimori, Takuji Yoshimura, Tomoko Namba, Atsuko Imai, Kaori Kobayashi, Ryoichi Imamura, Naotsugu Ichimaru, Kazuto Kato, Akihiro Nakaya, Shiro Takahara, Yoshitaka Isaka
Background: Medullary cystic kidney disease Type 1 is an autosomal dominant tubulointerstitial kidney disease (ADTKD). Recently, mucin 1 ( MUC1 ) was identified as a causal gene of medullary cystic kidney disease (ADTKD-MUC1). However, the MUC1 mutation was found to be a single cytosine insertion in a single copy of the GC-rich variable number of tandem repeats (VNTRs), which are very difficult to analyze by next-generation sequencing. To date, other mutations have not been detected in ADTKD-MUC1, and the mutant MUC1 protein has not been analyzed because of the difficulty of genetically modifying the VNTR sequence...
June 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29128598/histological-and-radiological-evaluation-of-subcutaneous-implants-in-mouse-of-a-3d-printable-material-fulcure-720-and-experimental-application-in-mandibular-reconstruction
#4
J Megías Barrera, L García-Consuegra, A Novoa, S Costilla, S Junquera, G Ascani
INTRODUCTION: The aim of this study was to evaluate the bioactivity of FullCure compared to porous polyethylene implants (Medpor) in rats prior to custom-made scaffold support manufacturing for mandible segmental defects (MSD) reconstruction in sheep. METHODS: 12 Fullcure and Medpor laminaes were implanted in the left and right dorsum respectively of 6 wistar rats. Toxicity was assessed by skin, kidney and liver histopathology 3 months post-implantation. Computed Tomography (CT) was carried out in order to assess radiological differences between implants...
November 8, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29127451/development-and-validation-of-3d-printed-virtual-models-for-robot-assisted-radical-prostatectomy-and-partial-nephrectomy-urologists-and-patients-perception
#5
Francesco Porpiglia, Riccardo Bertolo, Enrico Checcucci, Daniele Amparore, Riccardo Autorino, Prokar Dasgupta, Peter Wiklund, Ashutosh Tewari, Evangelos Liatsikos, Cristian Fiori
PURPOSE: To test the face and content validity of 3D virtual-rendered printed models used before robot-assisted prostate cancer and nephron-sparing surgery. METHODS: Patients who underwent live surgery during an international urological meeting organized in January 2017 were enrolled. Those with organ-confined prostate cancer underwent robot-assisted radical prostatectomy. Patients with a single renal tumor underwent minimally invasive nephron-sparing surgery. High-resolution (HR) imaging was obtained for all patients...
November 10, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29127321/metabolic-profiling-of-healthy-and-cancerous-tissues-in-2d-and-3d
#6
Shonagh Russell, Jonathan Wojtkowiak, Andy Neilson, Robert J Gillies
Metabolism is a compartmentalized process, and it is apparent in studying cancer that tumors, like normal tissues, demonstrate metabolic cooperation between different cell types. Metabolic profiling of cells in 2D culture systems often fails to reflect the metabolism occurring within tissues in vivo due to lack of other cell types and 3D interaction. We designed a tooling and methodology to metabolically profile and compare 2D cultures with cancer cell spheroids, and microtissue slices from tumors, and normal organs...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29126725/conformationally-rigid-derivatives-of-way-267-464-synthesis-and-pharmacology-at-the-human-oxytocin-and-vasopressin-1a-receptors
#7
William T Jorgensen, Damien W Gulliver, Timothy A Katte, Eryn L Werry, Tristan A Reekie, Mark Connor, Michael Kassiou
WAY-267,464 (1) and twelve conformationally rigid analogues (3a-f-4a-f) were synthesised, characterised and evaluated in cellular assays with the aim of systematically exploring interactions with the oxytocin receptor (OTR). Each analogue was evaluated in radioligand binding displacement assays at both human OTR and arginine vasopressin 1a receptors (V1aR). Physiological characterisation was determined by whole cell IP1 accumulation assays on stably transfected human embryonic kidney (HEK) cells. Incorporation of the rigid, optionally substituted benzene ring abolished OTR activity and diminished V1aR pharmacology when compared to 1...
October 23, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29104526/-tissue-papers-from-organ-specific-decellularized-extracellular-matrices
#8
Adam E Jakus, Monica M Laronda, Alexandra S Rashedi, Christina M Robinson, Chris Lee, Sumanas W Jordan, Kyle E Orwig, Teresa K Woodruff, Ramille N Shah
Using an innovative, tissue-independent approach to decellularized tissue processing and biomaterial fabrication, the development of a series of "tissue papers" derived from native porcine tissues/organs (heart, kidney, liver, muscle), native bovine tissue/organ (ovary and uterus), and purified bovine Achilles tendon collagen as a control from decellularized extracellular matrix particle ink suspensions cast into molds is described. Each tissue paper type has distinct microstructural characteristics as well as physical and mechanical properties, is capable of absorbing up to 300% of its own weight in liquid, and remains mechanically robust (E = 1-18 MPa) when hydrated; permitting it to be cut, rolled, folded, and sutured, as needed...
September 13, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/29103476/evaluation-of-fetal-kidney-growth-using-ultrasound-a-systematic-review
#9
REVIEW
Sonja Brennan, David Watson, Donna Rudd, Michal Schneider, Yogavijayan Kandasamy
PURPOSE: To determine the role of ultrasound imaging in evaluating fetal kidney growth. METHODS: MEDLINE, CINAHL and EMBASE databases were electronically searched for studies between 1996 and January 2017 and limited to English language. Studies were included if they reported on an ultrasound technique to assess fetal kidney growth and they were not a case report or case series. There was independent selection of studies by two reviewers in consensus with one other reviewer...
November 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29103469/improved-clinical-workflow-for-simultaneous-whole-body-pet-mri-using-high-resolution-caipirinha-accelerated-mr-based-attenuation-correction
#10
Martin T Freitag, Matthias Fenchel, Philipp Bäumer, Thorsten Heußer, Christopher M Rank, Marc Kachelrieß, Daniel Paech, Klaus Kopka, Sebastian Bickelhaupt, Antonia Dimitrakopoulou-Strauss, Klaus Maier-Hein, Ralf Floca, Mark E Ladd, Heinz-Peter Schlemmer, Florian Maier
PURPOSE: To explore the value and reproducibility of a novel magnetic resonance based attenuation correction (MRAC) using a CAIPIRINHA-accelerated T1-weighted Dixon 3D-VIBE sequence for whole-body PET/MRI compared to the clinical standard. METHODS: The PET raw data of 19 patients from clinical routine were reconstructed with standard MRAC (MRACstd) and the novel MRAC (MRACcaipi), a prototype CAIPIRINHA accelerated Dixon 3D-VIBE sequence, both acquired in 19 s/bed position...
November 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29101551/novel-semi-automated-kidney-volume-measurements-in-autosomal-dominant-polycystic-kidney-disease
#11
Satoru Muto, Haruna Kawano, Shuji Isotani, Hisamitsu Ide, Shigeo Horie
BACKGROUND: We assessed the effectiveness and convenience of a novel semi-automatic kidney volume (KV) measuring high-speed 3D-image analysis system SYNAPSE VINCENT(®) (Fuji Medical Systems, Tokyo, Japan) for autosomal dominant polycystic kidney disease (ADPKD) patients. METHODS: We developed a novel semi-automated KV measurement software for patients with ADPKD to be included in the imaging analysis software SYNAPSE VINCENT(®). The software extracts renal regions using image recognition software and measures KV (VINCENT KV)...
November 3, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29101326/monitoring-and-manipulating-cellular-crosstalk-during-kidney-fibrosis-inside-a-3d-in-vitro-co-culture
#12
Bramasta Nugraha, Manuel A Mohr, Aaron Ponti, Maximilian Y Emmert, Franziska Weibel, Simon P Hoerstrup, Solange Moll, Ulrich Certa, Marco Prunotto, Periklis Pantazis
In pharmacological research the development of promising lead compounds requires a detailed understanding of the dynamics of disease progression. However, for many diseases, such as kidney fibrosis, gaining such understanding requires complex real-time, multi-dimensional analysis of diseased and healthy tissue. To allow for such studies with increased throughput we established a dextran hydrogel-based in vitro 3D co-culture as a disease model for kidney fibrosis aimed at the discovery of compounds modulating the epithelial/mesenchymal crosstalk...
November 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29100091/mutations-in-greb1l-cause-bilateral-kidney-agenesis-in-humans-and-mice
#13
Lara De Tomasi, Pierre David, Camille Humbert, Flora Silbermann, Christelle Arrondel, Frédéric Tores, Stéphane Fouquet, Audrey Desgrange, Olivier Niel, Christine Bole-Feysot, Patrick Nitschké, Joëlle Roume, Marie-Pierre Cordier, Christine Pietrement, Bertrand Isidor, Philippe Khau Van Kien, Marie Gonzales, Marie-Hélène Saint-Frison, Jelena Martinovic, Robert Novo, Juliette Piard, Christelle Cabrol, Ishwar C Verma, Ratna Puri, Hubert Journel, Jacqueline Aziza, Laurent Gavard, Marie-Hélène Said-Menthon, Laurence Heidet, Sophie Saunier, Cécile Jeanpierre
Congenital anomalies of the kidney and urinary tract (CAKUT) constitute a major cause of chronic kidney disease in children and 20% of prenatally detected anomalies. CAKUT encompass a spectrum of developmental kidney defects, including renal agenesis, hypoplasia, and cystic and non-cystic dysplasia. More than 50 genes have been reported as mutated in CAKUT-affected case subjects. However, the pathophysiological mechanisms leading to bilateral kidney agenesis (BKA) remain largely elusive. Whole-exome or targeted exome sequencing of 183 unrelated familial and/or severe CAKUT-affected case subjects, including 54 fetuses with BKA, led to the identification of 16 heterozygous variants in GREB1L (growth regulation by estrogen in breast cancer 1-like), a gene reported as a target of retinoic acid signaling...
November 2, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29097409/optimizing-image-quantification-for-lu-177-spect-ct-based-on-a-3d-printed-2-compartment-kidney-phantom
#14
Johannes Tran-Gia, Michael Lassmann
The aim of this work was to find an optimal setup for activity determination of Lu-177-based single photon emission computed tomography (SPECT) / computed tomography (CT) imaging reconstructed with two commercially available reconstructions (xSPECT Quant and Flash3D, Siemens Healthcare). For this purpose, 3D printed phantoms of different geometries were manufactured, different partial volume correction (PVC) methods were applied, and the accuracy of the activity determination was evaluated. METHODS: A 2-compartment kidney phantom (70% cortical and 30% medullary compartment), a sphere, and an ellipsoid of equal volumes were 3D printed, filled with Lu-177, and scanned with a SPECT/CT system...
November 2, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29092847/measuring-rat-kidney-glomerular-number-and-size-in-vivo-with-mri
#15
Edwin J Baldelomar, Jennifer R Charlton, Scott C Beeman, Kevin M Bennett
Nephron number is highly variable in humans and is thought to play an important role in renal health. Chronic kidney disease (CKD) is the result of too few nephrons to maintain homeostasis. Currently, nephron number estimates can only be determined invasively or as a terminal assessment. Due to a lack of tools to measure and track nephron number in the living, the early stages of CKD often go unrecognized, preventing early intervention that might halt the progression of CKD. In this work, we present a technique to directly measure glomerular number (Nglom) and volume in vivo in the rat kidney (n=8) using MRI enhanced with the novel contrast agent cationized ferritin (CFE-MRI)...
November 1, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29074823/-update-on-recent-progress-in-vitamin-d-research-vitamin-d-metabolism-and-its-regulation
#16
Toshimi Michigami
Vitamin D is taken up from food as D2 and D3. Vitamin D3 is also synthesized from 7-dehydrocholesterol in the skin by the exposure of ultraviolet B. The D2 and D3, which are called native vitamin D, are hydroxylated at C25 in the liver by CYP2R1 and then at C1 in the kidney by CYP27B1, to be converted to an active vitamin D metabolite, 1,25-dihydroxyvitamin D[1,25(OH)2D]. CYP24A1 converts 25-hydroxyvitamin D(25OHD)and 1,25(OH)2D to 24,25-dihydroxyvitamin D[24,25(OH)2D]and 1,24,25-trihydroxyvitamin D[1,24,25(OH)3D], respectively, to decrease the level of 1,25(OH)2D...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/29065798/microphysiologic-systems-in-female-reproductive-biology
#17
REVIEW
Alexandria N Young, Georgette Moyle-Heyrman, J Julie Kim, Joanna E Burdette
Microphysiologic systems (MPS), including new organ-on-a-chip technologies, recapitulate tissue microenvironments by employing specially designed tissue or cell culturing techniques and microfluidic flow. Such systems are designed to incorporate physiologic factors that conventional 2D or even 3D systems cannot, such as the multicellular dynamics of a tissue-tissue interface or physical forces like fluid sheer stress. The female reproductive system is a series of interconnected organs that are necessary to produce eggs, support embryo development and female health, and impact the functioning of non-reproductive tissues throughout the body...
November 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29048214/validation-of-a-full-immersion-simulation-platform-for-percutaneous-nephrolithotomy-using-3d-printing-technology
#18
Ahmed Ghazi, Timothy Campbell, Rachel Melnyk, Changyong Feng, Alex Andrusco, Jonathan Stone, Erdal Erturk
INTRODUCTION AND OBJECTIVES: The restriction of resident hours with an increasing focus on patient safety and a reduced caseload has impacted surgical training. A complex and complication prone procedure such as percutaneous nephrolithotomy (PCNL) with a steep learning curve may create an unsafe environment for hands-on resident training. In this study, we validate a high fidelity, inanimate PCNL model within a full immersion simulation environment. METHODS: Anatomically correct models of the human pelvicalyceal system (PCS), kidney, and relevant adjacent structures were created using poly-vinyl alcohol (PVA) hydrogels and 3D-printed injection molds...
October 19, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29041614/fast-two-snapshot-structured-illumination-for-temporal-focusing-microscopy-with-enhanced-axial-resolution
#19
Yunlong Meng, Wei Lin, Chenglin Li, Shih-Chi Chen
We present a new two-snapshot structured light illumination (SLI) reconstruction algorithm for fast image acquisition. The new algorithm, which only requires two mutually π phase-shifted raw structured images, is implemented on a custom-built temporal focusing fluorescence microscope (TFFM) to enhance its axial resolution via a digital micromirror device (DMD). First, the orientation of the modulated sinusoidal fringe patterns is automatically identified via spatial frequency vector detection. Subsequently, the modulated in-focal-plane images are obtained via rotation and subtraction...
September 18, 2017: Optics Express
https://www.readbyqxmd.com/read/29038888/simultaneous-whole-body-18-f-psma-1007-pet-mri-with-integrated-high-resolution-multiparametric-imaging-of-the-prostatic-fossa-for-comprehensive-oncological-staging-of-patients-with-prostate-cancer-a-pilot-study
#20
Martin T Freitag, Claudia Kesch, Jens Cardinale, Paul Flechsig, Ralf Floca, Matthias Eiber, David Bonekamp, Jan P Radtke, Clemens Kratochwil, Klaus Kopka, Markus Hohenfellner, Albrecht Stenzinger, Heinz-Peter Schlemmer, Uwe Haberkorn, Frederik Giesel
INTRODUCTION: The aim of the present study was to explore the clinical feasibility and reproducibility of a comprehensive whole-body (18)F-PSMA-1007-PET/MRI protocol for imaging prostate cancer (PC) patients. METHODS: Eight patients with high-risk biopsy-proven PC underwent a whole-body PET/MRI (3 h p.i.) including a multi-parametric prostate MRI after (18)F-PSMA-1007-PET/CT (1 h p.i.) which served as reference. Seven patients presented with non-treated PC, whereas one patient presented with biochemical recurrence...
October 16, 2017: European Journal of Nuclear Medicine and Molecular Imaging
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