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Tomoo Kishaba, Yuichiro Nei, Masashi Momose, Hiroaki Nagano, Shin Yamashiro
Objective: Idiopathic pulmonary fibrosis (IPF) is the most common parenchymal lung disease. Patients with IPF sometimes develop acute exacerbation (AE), which predicts a poor prognosis. To evaluate the predictors of 90-day mortality of AE in patients with IPF based on the new 2016 criteria. Materials and Methods: Sixty-five patients with AE were studied retrospectively between January 2001 and December 2016 at Okinawa Chubu Hospital. Results: The mean age of the patients was 74 years, with 40 (61...
February 2018: Eurasian Journal of Medicine
Jihad A Mustapha, Alexandra Lansky, Mehdi Shishehbor, John Miles McClure, Sarah Johnson, Thomas Davis, Prakash Makam, William Crowder, Eitan Konstantino, Robert R Attaran
The Chocolate BAR study is a prospective multicenter post-market registry designed to evaluate the safety and performance of the Chocolate percutaneous transluminal angioplasty balloon catheter in a broad population with symptomatic peripheral arterial disease. The primary endpoint is acute procedural success (defined as ≤30% residual stenosis without flow-limiting dissection); secondary long-term outcomes include freedom from target lesion revascularization (TLR), major unplanned amputation, survival, and patency...
March 7, 2018: Catheterization and Cardiovascular Interventions
Rasmus Gregersen, Kristoffer Andresen, Jakob Burcharth, Hans-Christian Pommergaard, Jacob Rosenberg
PURPOSE: The study aimed to investigate long-term mortality, recurrence, and death related to recurrence for patients admitted with acute diverticulitis with abscess formation (Hinchey stage Ib-II). METHODS: The cohort was identified by linking administrative registers for all Danish citizens in years 2000-2012. Patients were identified from ICD-10 discharge codes and stratified according to treatment (antibiotics, percutaneous abscess drainage, or surgery). RESULTS: From 6,641,672 persons, 3148 patients were identified with acute diverticulitis with abscess formation...
March 6, 2018: International Journal of Colorectal Disease
Birkneh Tilahun Tadesse, Byron Alexander Foster, Mulugeta Sitot Shibeshi, Henok Tadele Dangiso
Background: Bacterial meningitis is a significant cause of morbidity and mortality in the developing world. However, limited research has focused on the diagnosis and management of meningitis in resource-limited settings. Methods: We designed a prospective case series of children admitted to a large, academic referral hospital with acute meningitis syndrome. Data were collected on age, time of presentation, prior antibiotics, cerebrospinal fluid (CSF) parameters, antibiotic and steroid prescription, and clinical outcome...
November 2017: Ethiopian Journal of Health Sciences
Nathan A Franklin, Ashley Ali, Richard K Hurley, Hassan R Mir, Michael J Beltran
OBJECTIVE: Evaluate the pre-hospital use of Direct Oral Anticoagulant (DOAC) agents on the outcomes of early surgical fixation of a geriatric hip fracture. DESIGN: Case-Control. SETTING: Two academic level 1 trauma centers. INTERVENTION: Early (<48h) surgical fixation of a geriatric proximal femur fracture. PATIENTS: 19 patients receiving Pradaxa (Dabigatran), Eliquis (Apixaban), or Xarelto (Rivaroxaban) who underwent surgery between 2010 and 2015 and 74 control patients...
February 9, 2018: Journal of Orthopaedic Trauma
M Pourhassan, K Norman, M J Müller, R Dziewas, R Wirth
OBJECTIVES: However, the information regarding the impact of sarcopenia on mortality in older individuals is rising, there is a lack of knowledge concerning this issue among geriatric hospitalized patients. Therefore, aim of the present study was to investigate the associations between sarcopenia and 1-year mortality in a prospectively recruited sample of geriatric inpatients with different mobility and dependency status. DESIGN AND SETTING: Sarcopenia was diagnosed using the criteria of the European Working Group on Sarcopenia in Older People (EWGSOP)...
2018: Journal of Frailty & Aging
Ling-Xin Chen, Angelo De Mattos, Heejung Bang, Catherine T Vu, Mehul Gandhi, Muna Alnimri, Brian Gallay, Ghaneh Fananapazir
OBJECTIVE: To compare outcomes between percutaneous transluminal angioplasty and stent placement in the treatment of TRAS. METHODS: We retrospectively studied patients who underwent angiography for TRAS between 1/1/2008 and 9/20/2016 at one center. We compared the rates of restenosis in patients who were treated with angioplasty alone versus those who were treated with stenting. Secondary outcomes included serum creatinine and blood pressure after intervention and graft and patient survival...
February 2, 2018: Clinical Transplantation
Musi Gennaro, Francesco Alessandro Mistretta, Carlo Marenghi, Andrea Russo, Michele Catellani, Sebastiano Nazzani, Andrea Conti, Stefano Luzzago, Matteo Ferro, Deliu Victor Matei, Luca Carmignani, Ottavio De Cobelli
Introduction To evaluate the efficacy and safety of ureteroscopic thulium laser treatment of upper urinary tract carcinoma (UTUC). Material and Methods Forty-two consecutive patients underwent conservative thulium laser treatment for UTUC at two referral institutions. All patients underwent preliminary biopsy and then laser vaporization. A 272 μm and a 365 μm laser fibers were used with a flexible and semirigid scope, respectively. Ablation was carried out with a 10-20 Watt power. Results Mean age at surgery was 68 years old (SD 10...
January 22, 2018: Journal of Endourology
Marc Schindewolf, Torsten Fuss, Hanspeter Fink, Armin Gemperli, Axel Haine, Iris Baumgartner
Data on efficacy outcomes of endovascular versus surgical revascularization in patients with critical limb ischemia (CLI) in contemporary practice are limited. In this prospective cohort study, 353 consecutive patients with CLI were enrolled and allocated to endovascular (PTA [percutaneous transluminal angioplasty]), surgical (SURG), or no revascularization (No REVASC) after interdisciplinary consensus. Outcome measures were sustained primary clinical success (sPCS; survival without major amputation, repeated target extremity revascularization, and freedom from CLI), limb salvage, and amputation-free survival...
January 1, 2018: Angiology
Edward Koifman, Michael J Lipinski, Kyle Buchanan, Won Yu Kang, Ricardo O Escarcega, Ron Waksman, Nelson L Bernardo
OBJECTIVES: We sought to compare treatment strategies in a Bayesian network meta-analysis of randomized controlled trials. BACKGROUND: Peripheral artery disease (PAD) is a prevalent morbidity that is treated with various strategies. METHODS: We performed a MEDLINE search for randomized studies comparing at least 2 treatment strategies, including bypass surgery, percutaneous transluminal angioplasty (PTA) balloons, stents, covered stents, drug-eluting stents (DES), and drug-coated balloons (DCB), in patients with native femoro-popliteal disease...
January 14, 2018: Catheterization and Cardiovascular Interventions
Argiris Asderakis, Usman Khalid, Susanna Madden, Colin Dayan
Socioeconomic deprivation is associated with poorer outcomes in chronic diseases. The aim of this study was to investigate the effect of socioeconomic deprivation on outcomes following pancreas transplantation among patients transplanted in England. We included all 1270 pancreas recipients transplanted between 2004 and 2012. We used the English Index of Multiple Deprivation (EIMD) score to assess the influence of socioeconomic deprivation on patient and pancreas graft survival. Higher scores mean higher deprivation status...
December 23, 2017: American Journal of Transplantation
Caroline King, Sidney Atwood, Chris Brown, Adrianne Katrina Nelson, Mia Lozada, Jennie Wei, Maricruz Merino, Cameron Curley, Olivia Muskett, Samantha Sabo, Vikas Gampa, John Orav, Sonya Shin
OBJECTIVES: To evaluate the role of primary care healthcare delivery on survival for American Indian patients with diabetes in the southwest United States. METHODS: Data from patients with diabetes admitted to Gallup Indian Medical Center between 2009 and 2016 were analyzed using a log-rank test and Cox Proportional Hazards analyses. RESULTS: Of the 2661 patients included in analysis, 286 patients died during the study period. Having visited a primary care provider in the year prior to first admission of the study period was protective against all-cause mortality in unadjusted analysis (HR (95% CI)=0...
December 8, 2017: Primary Care Diabetes
Dominic H Tang, Sylvia Yan, Sarah R Ottenhof, Désirée Draeger, Adam S Baumgarten, Juan Chipollini, Chris Protzel, Yao Zhu, Ding-Wei Ye, Oliver W Hakenberg, Simon Horenblas, Nicholas A Watkin, Philippe E Spiess
INTRODUCTION: Although the trend towards penile sparing therapy is increasing for penile squamous cell carcinoma, outcomes for laser ablation therapy have not been widely reported. We assessed the clinical outcomes of penile cancer patients treated with only laser ablation. MATERIALS AND METHODS: A retrospective review was performed on 161 patients across 5 multi-center tertiary referral centers from 1985 to 2015. All patients underwent penile sparing surgery with only laser ablation for squamous cell carcinoma of the penis...
October 30, 2017: Urologic Oncology
Ji Yoon Choi, Joo Hee Jung, Sung Shin, Young Hoon Kim, Duck Jong Han
Pancreas transplantation is considered a therapeutic option for patients with complicated diabetes mellitus. In this study, we compared survival rate between patients on the waiting list for pancreas transplant alone(PTA), simultaneous pancreas-kidney(SPK) transplant, and pancreas after kidney(PAK) transplant and transplant recipients. A total of 503 patients (PTA:n = 116; SPK:n = 303; PAK:n = 84) and 280 PT recipients (PTA:n = 89; SPK:n = 155; PAK:n = 36) were retrospectively analyzed at our center between February 2000 and December 2015; 11...
2017: PloS One
Amit Akirov, Tzipora Shochat, Amir Shechvitz, Ilan Shimon, Talia Diker-Cohen, Eyal Robenshtok
CONTEXT: Limited data is available regarding the association between pre-admission thyroid function and prognosis of hospitalized patients treated for hypothyroidism. OBJECTIVE: Evaluate an association between thyroid stimulating hormone (TSH) levels and mortality in hospitalized levothyroxine-treated patients. DESIGN AND SETTING: Observational data of patients admitted to medical wards between 2011 and 2013. TSH levels obtained up to 180 days prior to admission were stratified as follows: low (≤0...
December 2017: Endocrine
Shiqiang Zhang, Jun Wang, Xinyu Zhang, Fangjian Zhou
Tumor-infiltrating lymphocytes (TILs) are associated with better clinical outcomes in many tumors. TILs represent a cell-mediated immune response against the carcinoma. CD8+ TILs are a crucial component of cell-mediated immunity. The significance of CD8+ TILs has not been reported respectively in organ- and non-organ-confined urothelial carcinoma (UC) of the bladder. We explored the prognostic value of CD8+ TILs in the two groups. The presence of CD8+ TILs was assessed by immunohistochemical staining of whole tissue sections from 75 organ and 51 non-organ-confined disease patients with long-term follow-up, and its correlation with clinicopathological features and overall survival (OS) was determined...
2017: PeerJ
Teruo Inamoto, Hideyasu Matsuyama, Naokazu Ibuki, Kazumasa Komura, Kiyoshi Takahara, Kiyohide Fujimoto, Hiroaki Shiina, Shigeru Sakano, Kazuhiro Nagao, Makito Miyake, Yoshihiro Tatsumi, Hiroaki Yasumoto, Haruhito Azuma
BACKGROUND AND OBJECTIVES: Carcinoma in situ (CIS) in urothelial carcinoma generally has poor prognosis, but the outcomes of pure/primary CIS tumor (p-CIS) and the behavior of concomitant CIS (c-CIS) with pTa-pT4 upper tract urothelial carcinoma (UTUC) managed by nephroureterectomy has not been specified. The aim of our study was to explore the biological and prognostic features of c-CIS, compared with p-CIS. PATIENTS AND METHODS: We queried multicenter UTUC database...
October 13, 2017: Journal of Urology
Hongru Li, Yadong Xu, Hui Li
OBJECTIVE: To assess the prognostic and clinicopathological characteristics of CD147 in human bladder cancer. METHODS: Studies on CD147 expression in bladder cancer were retrieved from PubMed, EMBASE, the Cochrane Library, Web of Science, China National Knowledge Infrastructure, and the WanFang databases. Outcomes were pooled with meta-analyzing softwares RevMan 5.3 and STATA 14.0. RESULTS: Twenty-four studies with 25 datasets demonstrated that CD147 expression was higher in bladder cancer than in non-cancer tissues (OR=43...
September 22, 2017: Oncotarget
Sanne M Schreuder, Yvette M G A Hendrix, Jim A Reekers, Shandra Bipat
PURPOSE: To identify possible risk factors in predicting clinical outcome in critical limb ischemia (CLI) patients undergoing percutaneous transluminal angioplasty (PTA). MATERIALS AND METHODS: PubMed and EMBASE were searched for studies analyzing CLI and clinical outcome after PTA from January 2006 to April 2017. Outcome measures were ulcer healing, amputation free survival (AFS)/limb salvage and overall survival. Data on predictive factors for ulcer healing, AFS/limb salvage and survival were extracted...
September 18, 2017: Cardiovascular and Interventional Radiology
Enrico Gallitto, Mauro Gargiulo, Gianluca Faggioli, Rodolfo Pini, Chiara Mascoli, Antonio Freyrie, Stefano Ancetti, Andrea Stella
OBJECTIVE: Fenestrated and branched endovascular aneurysm repair (FB-EVAR) is a valid option to treat juxtarenal and pararenal abdominal aortic aneurysms and thoracoabdominal aortic aneurysms. Because successful deployment depends on complex maneuvers, hostile iliac artery anatomy (HIA) can prejudice the FB-EVAR outcome. The aim of the study was to evaluate the impact of HIA on FB-EVAR outcome. METHODS: Between 2010 and 2015, all patients undergoing FB-EVAR were prospectively categorized according to iliac anatomy (friendly iliac artery anatomy [FIA] or HIA)...
December 2017: Journal of Vascular Surgery
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