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https://www.readbyqxmd.com/read/29773451/total-hip-arthroplasty-for-posttraumatic-osteoarthritis-following-acetabular-fracture-a-systematic-review-of-characteristics-outcomes-and-complications
#1
Robert D Stibolt, Harshadkumar A Patel, Samuel R Huntley, Eva J Lehtonen, Ashish B Shah, Sameer M Naranje
PURPOSE: Posttraumatic arthritis (PTA) may develop years after acetabular fracture, hindering joint function and causing significant chronic musculoskeletal pain. Given the delayed onset of PTA, few studies have assessed outcomes of delayed total hip arthroplasty (THA) in acetabular fracture patients. This study systematically reviewed the literature for outcomes of THA in patients with PTA and prior acetabular fracture. METHODS: Pubmed, EMBASE, SCOPUS, and Cochrane library were searched for articles containing the keywords "acetabular", "fracture", "arthroplasty", and "post traumatic arthritis" published between 1995 and August 2017...
April 26, 2018: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/29739113/combination-of-micrornas-and-cytokines-a-method-for-better-evaluation-of-acute-on-chronic-liver-failure
#2
Chunwen Pu, Chunmeng Jiang, Lang Lang, Huang Hui, Zhidong Wang, Dapeng Ma, Yong Zhang
BACKGROUND: The aim was to establish expression profiles of microRNAs (miRNAs) in Peripheral Blood Mononuclear Cells (PBMC) and of plasma cytokines from the patients with hepatitis B virus related acute-on-chronic liver failure (HBV-ACLF) and high-risk of acute-on-chronic liver failure (ACLF) patients as well as healthy people and to examine the relationships between these profiles and clinical features. METHODS: Herein, we collected PBMCs and plasma from peripheral blood of HBV-ACLF and ACLF patients as well as healthy people...
March 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29738100/steroid-free-three-drug-maintenance-regimen-for-pancreas-transplant-alone-comparison-of-induction-with-rabbit-antithymocyte-globulin-rituximab
#3
Jonathan Fridell, Richard Mangus, Jeanne Chen, Tim Taber, Arianna E Cabrales, Asif Sharfuddin, Muhammad Yaqub, John Powelson
Graft survival following pancreas transplant alone (PTA) is inferior to other pancreas transplants. Steroid elimination is appealing, but a two drug maintenance strategy may be inadequate. Additionally, recipients tend to have diabetic nephropathy and do not tolerate nephrotoxic medications. A three-drug maintenance strategy permits immunosuppression through different mechanisms as well as an opportunity to use lower doses of the individual medications. Induction consisted of five doses of rabbit antithymocyte globulin (1 mg/kg/dose)...
May 8, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29734154/treatment-of-posttransplantation-anemia
#4
Kohei Unagami, Masayoshi Okumi, Tomomi Tamura, Hideki Ishida, Kazunari Tanabe, Kosaku Nitta
Kidney transplantation represents a renal replacement therapy for end-stage renal failure, with outcomes improving from year to year. With the improved survival prognosis, treatment of complications of chronic kidney disease after transplantation is becoming increasingly important. In particular, posttransplantation anemia (PTA) is often protracted, which could be related to a variety of factors, including the renal function status, graft rejection episodes, and infectious causes. PTA occurs in about 30-40% of transplant recipients, and is known to affect the function of the transplanted kidney as well as patient survival...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/29701407/creative-vascular-access-construction-in-same-patient
#5
Pedro Pinto Sousa, Paulo Almeida, Pedro Sá Pinto, Rui Almeida
INTRODUCTION: Creating and maintaining a functional vascular access(VA) is a critical factor in the survival of a dialysis patient. However, it will not function forever, implying a creative attitude from the vascular surgeon either to maintain its functionality or built a new one wherever possible, being it autologous or synthetic. METHODS: Describe the VA history of a 59years-old male with morbid obesity and end-stage chronic kidney disease. RESULTS: His VA construction started in2012 with failed attempts in both forearms until a functional brachiocephalic artery-venous fistula(AVF) in the right upper limb was achieved, but was deemed to ligation as severe venous hypertension secondary to central venous disease related to CVC use...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29695915/expression-of-pyruvate-kinase-m2-in-human-bladder-cancer-and-its-correlation-with-clinical-parameters-and-prognosis
#6
Changkun Huang, Zhichao Huang, Peiming Bai, Guangcheng Luo, Xiaokun Zhao, Xinjun Wang
Background: Pyruvate kinase M2 (PKM2) is a key regulator of the Warburg effect and has critical functions in glycolysis, contributing to the Warburg effect, tumor growth, angiogenesis, cell division, metastasis, and apoptosis. The high expression of PKM2 in various solid tumors renders it a potential biomarker of tumorigenesis and tumor invasion, but the expression and role of PKM2 in bladder cancer have not been studied extensively. Patients and methods: Western blot and immunohistochemistry (IHC) were used to measure the expression of PKM2, and quantitative real-time polymerase chain reaction (PCR) was performed to determine PKM2 mRNA levels...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29688881/withdrawn-surveillance-guidelines-based-on-recurrence-patterns-for-upper-tract-urothelial-carcinoma
#7
Jennifer A Locke, Reza Hamidizadeh, Wassim Kassouf, R Ricardo Rendon, David Bell, Jonathan Izawa, J Joseph Chin, Anil Kapoor, Bobby Shayegen, Jean-Baptiste Lattouf, Fred Saad, Louis Lacombe, Yves Fradet, Adrien Fairey, Niels-Eric Jacobson, Darrel Drachenberg, Ilias Cagiannos, Alan So, Peter C Black
Ahead of print article withdrawn bu publisher.
April 12, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29582126/endovascular-treatment-of-haemodialysis-arteriovenous-fistula-with-drug-coated-balloon-angioplasty-a-single-centre-study
#8
Jernej Lučev, Silva Breznik, Dejan Dinevski, Robert Ekart, Mitja Rupreht
PURPOSE: To evaluate the effect of percutaneous transluminal angioplasty (PTA) on haemodialysis fistulas utilising drug-coated balloons with plain balloon vessel preparation (DCB). MATERIALS AND METHODS: In the study group, 31 patients (16 men; mean age 62.8 ± 17.2 years) with failing arteriovenous fistulas were treated, with DCB, and compared with a control group (31 patients; 15 men; mean age 67.0 ± 8.44 years), in which only plain balloon PTA was performed...
March 26, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29566600/predicting-long-term-global-outcome-after-traumatic-brain-injury-tbi-development-of-a-practical-prognostic-tool-using-the-tbi-model-systems-national-database
#9
William Walker, Katherine A Stromberg, Jennifer H Marwitz, Adam Sima, Amma A Agyemang, Kristin M Graham, Cynthia L Harrison-Felix, Jeanne Hoffman, Allen W Brown, Jeffrey S Kreutzer, Randall Merchant
For patients surviving serious traumatic brain injury (TBI), families and other stakeholders often desire information on long-term functional prognosis, but accurate and easy-to-use clinical tools are lacking. We aimed to build utilitarian decision trees from commonly collected clinical variables to predict Glasgow Outcome Scale (GOS) functional levels at 1, 2, and 5-years after moderate to severe closed TBI. Flexible classification tree statistical modeling was used on prospectively collected data from the TBI-Model Systems (TBIMS) inception cohort study...
March 22, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29531483/clinical-characteristics-based-on-the-new-criteria-of-acute-exacerbation-in-patients-with-idiopathic-pulmonary-fibrosis
#10
Tomoo Kishaba, Yuichiro Nei, Masashi Momose, Hiroaki Nagano, Shin Yamashiro
Objective: Idiopathic pulmonary fibrosis (IPF) is the most common parenchymal lung disease. Patients with IPF sometimes develop acute exacerbation (AE), which predicts a poor prognosis. To evaluate the predictors of 90-day mortality of AE in patients with IPF based on the new 2016 criteria. Materials and Methods: Sixty-five patients with AE were studied retrospectively between January 2001 and December 2016 at Okinawa Chubu Hospital. Results: The mean age of the patients was 74 years, with 40 (61...
February 2018: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/29513389/a-prospective-multi-center-study-of-the-chocolate-balloon-in-femoropopliteal-peripheral-artery-disease-the-chocolate-bar-registry
#11
Jihad A Mustapha, Alexandra Lansky, Mehdi Shishehbor, John Miles McClure, Sarah Johnson, Thomas Davis, Prakash Makam, William Crowder, Eitan Konstantino, Robert R Attaran
The Chocolate BAR study is a prospective multicenter post-market registry designed to evaluate the safety and performance of the Chocolate percutaneous transluminal angioplasty balloon catheter in a broad population with symptomatic peripheral arterial disease. The primary endpoint is acute procedural success (defined as ≤30% residual stenosis without flow-limiting dissection); secondary long-term outcomes include freedom from target lesion revascularization (TLR), major unplanned amputation, survival, and patency...
May 1, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29511842/long-term-mortality-and-recurrence-in-patients-treated-for-colonic-diverticulitis-with-abscess-formation-a-nationwide-register-based-cohort-study
#12
Rasmus Gregersen, Kristoffer Andresen, Jakob Burcharth, Hans-Christian Pommergaard, Jacob Rosenberg
PURPOSE: The study aimed to investigate long-term mortality, recurrence, and death related to recurrence for patients admitted with acute diverticulitis with abscess formation (Hinchey stage Ib-II). METHODS: The cohort was identified by linking administrative registers for all Danish citizens in years 2000-2012. Patients were identified from ICD-10 discharge codes and stratified according to treatment (antibiotics, percutaneous abscess drainage, or surgery). RESULTS: From 6,641,672 persons, 3148 patients were identified with acute diverticulitis with abscess formation...
April 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29487467/empiric-treatment-of-acute-meningitis-syndrome-in-a-resource-limited-setting-clinical-outcomes-and-predictors-of-survival-or-death
#13
Birkneh Tilahun Tadesse, Byron Alexander Foster, Mulugeta Sitot Shibeshi, Henok Tadele Dangiso
Background: Bacterial meningitis is a significant cause of morbidity and mortality in the developing world. However, limited research has focused on the diagnosis and management of meningitis in resource-limited settings. Methods: We designed a prospective case series of children admitted to a large, academic referral hospital with acute meningitis syndrome. Data were collected on age, time of presentation, prior antibiotics, cerebrospinal fluid (CSF) parameters, antibiotic and steroid prescription, and clinical outcome...
November 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29432317/outcomes-of-early-surgical-intervention-in-geriatric-proximal-femur-fractures-among-patients-receiving-direct-oral-anticoagulation
#14
Nathan A Franklin, Ashley H Ali, Richard K Hurley, Hassan R Mir, Michael J Beltran
OBJECTIVE: To evaluate the prehospital use of direct oral anticoagulant (DOAC) agents on the outcomes of early surgical fixation of a geriatric hip fracture. DESIGN: Case control study. SETTING: Two academic Level 1 trauma centers. INTERVENTION: Early (<48 h) surgical fixation of a geriatric proximal femur fracture. PATIENTS: Nineteen patients receiving Pradaxa (dabigatran), Eliquis (apixaban), or Xarelto (rivaroxaban) who underwent surgery between 2010 and 2015 and 74 control patients...
June 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29412441/impact-of-sarcopenia-on-one-year-mortality-among-older-hospitalized-patients-with-impaired-mobility
#15
M Pourhassan, K Norman, M J Müller, R Dziewas, R Wirth
OBJECTIVES: However, the information regarding the impact of sarcopenia on mortality in older individuals is rising, there is a lack of knowledge concerning this issue among geriatric hospitalized patients. Therefore, aim of the present study was to investigate the associations between sarcopenia and 1-year mortality in a prospectively recruited sample of geriatric inpatients with different mobility and dependency status. DESIGN AND SETTING: Sarcopenia was diagnosed using the criteria of the European Working Group on Sarcopenia in Older People (EWGSOP)...
2018: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29394514/angioplasty-vs-stent-in-the-treatment-of-transplant-renal-artery-stenosis
#16
Ling-Xin Chen, Angelo De Mattos, Heejung Bang, Catherine T Vu, Mehul Gandhi, Muna Alnimri, Brian Gallay, Ghaneh Fananapazir
OBJECTIVE: To compare outcomes between percutaneous transluminal angioplasty and stent placement in the treatment of transplant renal artery stenosis (TRAS). METHODS: We retrospectively studied patients who underwent angiography for TRAS between 1/1/2008 and 9/20/2016 at 1 center. We compared the rates of restenosis in patients who were treated with angioplasty alone vs those who were treated with stenting. Secondary outcomes included serum creatinine and blood pressure after intervention and graft and patient survival...
April 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29357686/thulium-laser-treatment-of-upper-urinary-tract-carcinoma-a-multi-institutional-analysis-of-surgical-and-oncological-outcomes
#17
Gennaro Musi, Francesco A Mistretta, Carlo Marenghi, Andrea Russo, Michele Catellani, Sebastiano Nazzani, Andrea Conti, Stefano Luzzago, Matteo Ferro, Deliu V Matei, Luca Carmignani, Ottavio de Cobelli
INTRODUCTION: To evaluate the efficacy and safety of ureteroscopic thulium laser (TL) treatment of upper urinary tract carcinoma (UTUC). MATERIALS AND METHODS: Forty-two consecutive patients underwent conservative TL treatment for UTUC at two referral institutions. All patients underwent preliminary biopsy and then laser vaporization. A 272 μm and 365 μm laser fibers were used with a flexible and semirigid scope, respectively. Ablation was carried out with a 10 to 20 W power...
March 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29355026/efficacy-outcomes-of-endovascular-versus-surgical-revascularization-in-critical-limb-ischemia-results-from-a-prospective-cohort-study
#18
Marc Schindewolf, Torsten Fuss, Hanspeter Fink, Armin Gemperli, Axel Haine, Iris Baumgartner
Data on efficacy outcomes of endovascular versus surgical revascularization in patients with critical limb ischemia (CLI) in contemporary practice are limited. In this prospective cohort study, 353 consecutive patients with CLI were enrolled and allocated to endovascular (PTA [percutaneous transluminal angioplasty]), surgical (SURG), or no revascularization (No REVASC) after interdisciplinary consensus. Outcome measures were sustained primary clinical success (sPCS; survival without major amputation, repeated target extremity revascularization, and freedom from CLI), limb salvage, and amputation-free survival...
January 1, 2018: Angiology
https://www.readbyqxmd.com/read/29332315/comparison-of-treatment-strategies-for-femoro-popliteal-disease-a-network-meta-analysis
#19
Edward Koifman, Michael J Lipinski, Kyle Buchanan, Won Yu Kang, Ricardo O Escarcega, Ron Waksman, Nelson L Bernardo
OBJECTIVES: We sought to compare treatment strategies in a Bayesian network meta-analysis of randomized controlled trials. BACKGROUND: Peripheral artery disease (PAD) is a prevalent morbidity that is treated with various strategies. METHODS: We performed a MEDLINE search for randomized studies comparing at least 2 treatment strategies, including bypass surgery, percutaneous transluminal angioplasty (PTA) balloons, stents, covered stents, drug-eluting stents (DES), and drug-coated balloons (DCB), in patients with native femoro-popliteal disease...
January 14, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29275542/the-influence-of-socioeconomic-deprivation-on-outcomes-in-pancreas-transplantation-in-england-registry-data-analysis
#20
Argiris Asderakis, Usman Khalid, Susanna Madden, Colin Dayan
Socioeconomic deprivation is associated with poorer outcomes in chronic diseases. The aim of this study was to investigate the effect of socioeconomic deprivation on outcomes following pancreas transplantation among patients transplanted in England. We included all 1270 pancreas recipients transplanted between 2004 and 2012. We used the English Index of Multiple Deprivation (EIMD) score to assess the influence of socioeconomic deprivation on patient and pancreas graft survival. Higher scores mean higher deprivation status...
December 23, 2017: American Journal of Transplantation
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