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https://www.readbyqxmd.com/read/28463979/gastric-mucosal-status-in-populations-with-a-low-prevalence-of-helicobacter-pylori-in-indonesia
#1
Muhammad Miftahussurur, Iswan Abbas Nusi, Fardah Akil, Ari Fahrial Syam, I Dewa Nyoman Wibawa, Yudith Annisa Ayu Rezkitha, Ummi Maimunah, Phawinee Subsomwong, Muhammad Luthfi Parewangi, I Ketut Mariadi, Pangestu Adi, Tomohisa Uchida, Herry Purbayu, Titong Sugihartono, Langgeng Agung Waskito, Hanik Badriyah Hidayati, Maria Inge Lusida, Yoshio Yamaoka
In Indonesia, endoscopy services are limited and studies about gastric mucosal status by using pepsinogens (PGs) are rare. We measured PG levels, and calculated the best cutoff and predictive values for discriminating gastric mucosal status among ethnic groups in Indonesia. We collected gastric biopsy specimens and sera from 233 patients with dyspepsia living in three Indonesian islands. When ≥5.5 U/mL was used as the best cutoff value of Helicobacter pylori antibody titer, 8.6% (20 of 233) were positive for H...
2017: PloS One
https://www.readbyqxmd.com/read/28405319/family-history-is-an-independent-risk-factor-for-the-progression-of-gastric-atrophy-among-patients-with-helicobacter-pylori-infection
#2
Toshihiro Nishizawa, Hidekazu Suzuki, Kosuke Sakitani, Hiroharu Yamashita, Shuntaro Yoshida, Keisuke Hata, Takamitsu Kanazawa, Naoto Fujiwara, Takanori Kanai, Naohisa Yahagi, Osamu Toyoshima
BACKGROUND AND AIM: Risk factors for progression of gastric atrophy have not been fully elucidated. The aim of this study was to evaluate the risk factors for the development of atrophic gastritis in patients with Helicobacter pylori (H. pylori ) infection. METHODS: We reviewed 206 H. pylori-infected patients retrospectively. Endoscopic gastric atrophy was classified into closed- and open-type. We conducted univariate and multivariate logistic regression analyses on the contribution of age, sex, body mass index, past history of cancer, the first-degree family history of gastric cancer, habitual smoking and alcohol drinking, and endoscopic findings of gastric ulcer or duodenal ulcer for open-type gastric atrophy...
February 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28350854/expression-of-claudin-11-23-in-different-gastric-tissues-and-its-relationship-with-the-risk-and-prognosis-of-gastric-cancer
#3
Youzhu Lu, Jingjing Jing, Liping Sun, Yuehua Gong, Moye Chen, Zeyang Wang, Mingjun Sun, Yuan Yuan
Claudins play an important role in regulating the permeability of epithelial and endothelial cells and in the maintenance of cell polarity. We aimed to investigate expression of claudin-11, -23 in different gastric tissues and its relationship with clinicopathologic parameters and prognosis of gastric cancer. We compared their expression levels in the paired cancerous tissues versus those in the adjacent noncancerous tissues by real-time PCR, western blotting and immunohistochemistry. The results showed that the expression of claudin-11, -23 was greatly increased in paracancerous gastric tissue compared with cancerous tissue...
2017: PloS One
https://www.readbyqxmd.com/read/28339518/pain-interference-and-incident-medical-disorders-in-the-general-population
#4
Declan T Barry, Corey E Pilver Glenn, Rani A Hoff, Marc N Potenza
Objective. : To investigate the longitudinal relationship between pain interference and incident general medical conditions in a nationally representative sample. Methods. : Secondary data analysis comprising chi-square tests and binomial logistic regression analyses were performed on data obtained from the US National Epidemiologic Survey on Alcohol and Related Conditions from 34,465 adult respondents who completed wave 1 (2000-2001) and wave 2 (2004-2005) data collection...
October 20, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28320722/in-vitro-and-in-vivo-antibacterial-activities-of-patchouli-alcohol-a-natural-occurring-tricyclic-sesquiterpene-against-helicobacter-pylori-infection
#5
Y F Xu, D W Lian, Y Q Chen, Y F Cai, Y F Zheng, P L Fan, W K Ren, L J Fu, Y C Li, J H Xie, H Y Cao, B Tan, Z R Su, P Huang
This study further evaluated the in vitro and in vivo anti-Helicobacter pylori activity and potential underlying mechanism of patchouli alcohol (PA), a tricyclic sesquiterpene. In in vitro assay, the capacities of PA to inhibit and kill H. pylori were tested on three standard strains at different pH values and 12 clinical isolates. The effects of PA on H. pylori adhesion (and its alpA, alpB and babA genes), motility (and its flaA and flaB genes), ultrastructure and flagellation were investigated. Moreover, the H...
March 20, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28192107/gastrointestinal-complications-of-obesity
#6
Michael Camilleri, Harmeet Malhi, Andres Acosta
Obesity usually is associated with morbidity related to diabetes mellitus and cardiovascular diseases. However, there are many gastrointestinal and hepatic diseases for which obesity is the direct cause (eg, nonalcoholic fatty liver disease) or is a significant risk factor, such as reflux esophagitis and gallstones. When obesity is a risk factor, it may interact with other mechanisms and result in earlier presentation or complicated diseases. There are increased odds ratios or relative risks of several gastrointestinal complications of obesity: gastroesophageal reflux disease, erosive esophagitis, Barrett's esophagus, esophageal adenocarcinoma, erosive gastritis, gastric cancer, diarrhea, colonic diverticular disease, polyps, cancer, liver disease including nonalcoholic fatty liver disease, cirrhosis, hepatocellular carcinoma, gallstones, acute pancreatitis, and pancreatic cancer...
February 10, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28067243/association-of-polymorphisms-in-three-pri-mirnas-that-target-pepsinogen-c-with-the-risk-and-prognosis-of-gastric-cancer
#7
Ye-Feng Wu, Qian Xu, Cai-Yun He, Ying Li, Jing-Wei Liu, Na Deng, Li-Ping Sun, Yuan Yuan
We aimed to explore the associations of polymorphisms in three microRNAs (miRNAs) (let-7e rs8111742, miR-365b rs121224 and miR-4795 rs1002765) that target PGC with the risk and prognosis of gastric cancer/atrophic gastritis. Sequenom's MassArray was used to genotype the miRNA polymorphisms in 724 gastric cancer cases, 862 atrophic gastritis cases and 862 controls in a Chinese population. We found that let-7e rs8111742 and miR-4795 rs1002765 were associated with the risk of gastric cancer in the H. pylori-positive subgroup...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28032317/cinnamomulactone-a-new-butyrolactone-from-the-twigs-of-cinnamomum-cassia-and-its-inhibitory-activity-of-matrix-metalloproteinases
#8
Geum Jin Kim, Jong Yeong Lee, Hyun Gyu Choi, So Young Kim, Eonmi Kim, Sang Hee Shim, Joo-Won Nam, Sang-Hyun Kim, Hyukjae Choi
Cinnamomum cassia (Lauraceae) has long been used as one of the most frequently used traditional oriental medicines for the treatment of gastritis, diabetes, blood circulation disturbance and inflammatory diseases. Cinnamomulactone (1), a new butyrolactone was isolated from the twigs of C. cassia together with nine known compounds, coumarin (2), trans-cinnamic acid (3), cinnamaldehyde (4), 2-hydroxycinnamaldehyde (5), 2-methoxycinnamaldehyde (6), 2-hydroxy-cinnamyl alcohol (7), benzoic acid (8), (+)-syringaresinol (9) and phenethyl (E)-3-[4-methoxyphenyl]-2-propenoate (10)...
March 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/27890977/health-and-socioeconomic-status-of-the-elderly-people-living-in-hilly-areas-of-pakhribas-kosi-zone-nepal
#9
Ankit Amar Gupta, Amrit Kumar Lall, Aditi Das, Anshu Saurav, Abnish Nandan, Deepa Shah, Anand Agrahari, Deepak Kumar Yadav
BACKGROUND: The rising geriatric population is facing significant health and social problems in the developing world that are impacting the quality of their lives. OBJECTIVE: The study describes the general health status and the socioeconomic characteristics of the elderly people of Pakhribas village development committee (VDC) of Eastern Nepal. MATERIALS AND METHODS: Descriptive cross-sectional study was carried out targeting the people aged 60 years and above in the sample area using a semi-structured questionnaire and convenient sampling to get the required sample size...
October 2016: Indian Journal of Community Medicine
https://www.readbyqxmd.com/read/27806647/slow-release-l-cysteine-capsule-prevents-gastric-mucosa-exposure-to-carcinogenic-acetaldehyde-results-of-a-randomised-single-blinded-cross-over-study-of-helicobacter-associated-atrophic-gastritis
#10
Per M Hellström, Panu Hendolin, Pertti Kaihovaara, Leif Kronberg, Axel Meierjohann, Anders Millerhovf, Lea Paloheimo, Heidi Sundelin, Kari Syrjänen, Dominic-Luc Webb, Mikko Salaspuro
INTRODUCTION: Helicobacter-induced atrophic gastritis with a hypochlorhydric milieu is a risk factor for gastric cancer. Microbes colonising acid-free stomach oxidise ethanol to acetaldehyde, a recognised group 1 carcinogen. OBJECTIVE: To assess gastric production of acetaldehyde and its inert condensation product, non-toxic 2-methyl-1,3-thiazolidine-4-carboxylic acid (MTCA), after alcohol intake under treatment with slow-release L-cysteine or placebo. METHODS: Seven patients with biopsy-confirmed atrophic gastritis, low serum pepsinogen and high gastrin-17 were studied in a cross-over single-blinded design...
February 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27635116/protective-effect-of-amphipterygium-adstringens-extract-on-dextran-sulphate-sodium-induced-ulcerative-colitis-in-mice
#11
Mario Rodriguez-Canales, Ruben Jimenez-Rivas, Maria Margarita Canales-Martinez, Ana Judith Garcia-Lopez, Nelly Rivera-Yañez, Oscar Nieto-Yañez, Yadira Ledesma-Soto, Luvia Enid Sanchez-Torres, Miriam Rodriguez-Sosa, Luis Ignacio Terrazas, Marco Aurelio Rodriguez-Monroy
Amphipterygium adstringens is an endemic species in Mexico commonly known as "cuachalalate." Healers to treat gastritis, gastric ulcers, and gastrointestinal cancer have traditionally used the bark. We investigated the effects of alcoholic extract of A. adstringens (AaEE) in DSS-induced colitis in mice. The protective effect of AaEE was determined at 200 mg/kg by oral gavage for 10 days. We determine the effect of AaEE on clinical features (disease activity index), antioxidants, anti-inflammatory, and immunomodulatory activities in relation to the activity of SOD, CAT, and GPx, levels of proinflammatory cytokines, and changes both macroscopic and microscopic of the colonic mucosa...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27515959/the-role-on-endoscopy-in-alcohol-related-diseases
#12
Giuseppe Frieri, Brigida Galletti, Donatella Serva, Angelo Viscido
Alcohol, in addition to well-known damages on the liver and pancreas, produces direct and indirect injuries in the mucosa of the oesophagus, stomach, small intestine and large bowel. Different damages can be produced both when a large amount of alcohol is acutely drunk and when this is taken chronically. Almost all these lesions can be detected and treated by endoscopy as shown in the present article. When, over time, cirrhosis ensues the role of endoscopy is not different from that played with cirrhosis of different etiology...
2016: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/27400987/population-attributable-fraction-of-esophageal-squamous-cell-carcinoma-due-to-smoking-and-alcohol-in-uganda
#13
Samson Okello, Cristina Churchill, Rogers Owori, Benson Nasasira, Christine Tumuhimbise, Charles Lagoro Abonga, David Mutiibwa, David C Christiani, Kathleen E Corey
BACKGROUND: Despite the high rates and regional variation of esophageal squamous cell carcinoma (ESCC) in East Africa, the contributions of smoking and alcohol to the ESCC burden in the general population are unknown. METHODS: We conducted a case-control study of patients presenting for upper gastrointestinal endoscopic examination at Mbarara Regional Referral Hospital, Uganda. Sociodemographic data including smoking and alcohol intake were collected prior to endoscopy...
2016: BMC Cancer
https://www.readbyqxmd.com/read/27324707/quantifying-alcohol-related-emergency-admissions-in-a-uk-tertiary-referral-hospital-a-cross-sectional-study-of-chronic-alcohol-dependency-and-acute-alcohol-intoxication
#14
J Vardy, T Keliher, J Fisher, F Ritchie, C Bell, M Chekroud, F Clarey, L Blackwood, L Barry, E Paton, A Clark, R Connelly
OBJECTIVES: Alcohol is responsible for a proportion of emergency admissions to hospital, with acute alcohol intoxication and chronic alcohol dependency (CAD) implicated. This study aims to quantify the proportion of hospital admissions through our emergency department (ED) which were thought by the admitting doctor to be (largely or partially) a result of alcohol consumption. SETTING: ED of a UK tertiary referral hospital. PARTICIPANTS: All ED admissions occurring over 14 weeks from 1 September to 8 December 2012...
2016: BMJ Open
https://www.readbyqxmd.com/read/27184043/gastric-cancer-how-can-we-reduce-the-incidence-of-this-disease
#15
REVIEW
Caroline M den Hoed, Ernst J Kuipers
Gastric cancer remains a prevalent disease worldwide with a poor prognosis. Helicobacter pylori plays a major role in gastric carcinogenesis. H. pylori colonization leads to chronic gastritis, which predisposes to atrophic gastritis, intestinal metaplasia, dysplasia, and eventually gastric cancer. Screening, treatment, and prevention of H. pylori colonization can reduce the incidence of gastric cancer. Other interventions that may yield a similar effect, although of smaller magnitude, include promotion of a healthy lifestyle including dietary measures, non-smoking, low alcohol intake, and sufficient physical activity...
July 2016: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/27145686/ethylene-glycol-poisoning-in-three-dogs-importance-of-early-diagnosis-and-role-of-hemodialysis-as-a-treatment-option
#16
A Schweighauser, T Francey
Poisoning with ethylene glycol as contained in antifreeze can rapidly lead to irreversible acute renal failure and other organ damage. It carries a grave prognosis unless diagnosed early and adequate treatment is initiated within 8 hours of ingestion. Toxicity of ethylene glycol is related to the production of toxic metabolites by the enzyme alcohol dehydrogenase (ADH), leading to early signs of severe polyuria (PU) and polydipsia (PD), gastritis, ataxia and central nervous depression, followed by progressive dehydration, and ultimately oligoanuric renal failure...
February 2016: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/26978742/11%C3%AE-hydroxysteroid-dehydrogenase-inhibition-as-a-new-potential-therapeutic-target-for-alcohol-abuse
#17
P P Sanna, T Kawamura, J Chen, G F Koob, A J Roberts, L F Vendruscolo, V Repunte-Canonigo
The identification of new and more effective treatments for alcohol abuse remains a priority. Alcohol intake activates glucocorticoids, which have a key role in alcohol's reinforcing properties. Glucocorticoid effects are modulated in part by the activity of 11β-hydroxysteroid dehydrogenases (11β-HSD) acting as pre-receptors. Here, we tested the effects on alcohol intake of the 11β-HSD inhibitor carbenoxolone (CBX, 18β-glycyrrhetinic acid 3β-O-hemisuccinate), which has been extensively used in the clinic for the treatment of gastritis and peptic ulcer and is active on both 11β-HSD1 and 11β-HSD2 isoforms...
March 15, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/26735117/gastritis-in-the-alcoholic-relationship-to-gastric-alcohol-metabolism-and-helicobacter-pylori
#18
C S Lieber
Chronic gastritis is common in the alcoholic. It is characterized by histological inflammation of the gastric mucosa and is associated with variable symptomatology. Its etiology is still the subject of debate. Recently, a new alcohol dehydrogenase isoenzyme, called sigma ADH, absent from the liver but predominant in the upper GI tract, has been fully characterized, its gene cloned, and it appears to play a major role in gastric ethanol metabolism. Indeed, it has now been established, both in vivo in experimental animals and in vitro in cultured human gastric cells, that alcohol is metabolized in the gastric mucosa, resulting in the production of acetaldehyde, a toxic metabolite...
October 1998: Addiction Biology
https://www.readbyqxmd.com/read/26722050/stomach-specific-biomarkers-gastropanel-can-predict-the-development-of-gastric-cancer-in-a-caucasian-population-a-longitudinal-nested-case-control-study-in-siberia
#19
Svetlana Kurilovich, Anna Belkovets, Oleg Reshetnikov, Tatyana Openko, Sofja Malyutina, Ylija Ragino, Lilija Scherbakova, Marcis Leja, Lea Paloheimo, Kari Syrjänen, Mikhail Voevoda
BACKGROUND/AIM: Atrophic gastritis (AG) is the most important risk condition for gastric cancer (GC). A panel of stomach-specific serum biomarkers: pepsinogen (PG) I, pepsinogen (PG) II, gastrin-17 (G-17), and IgG antibodies to H. pylori (HP-Ab) detects the extent and grade of AG. The aim of the present study was to assess the predictive value of this 4-biomarker panel (GastroPanel, Biohit Oyj, Helsinki, Finland) in a case-control setting nested within a cohort of Caucasian population in Western Siberia...
January 2016: Anticancer Research
https://www.readbyqxmd.com/read/26690981/helicobacter-pylori-in-gastric-carcinogenesis
#20
REVIEW
Hyo Jun Ahn, Dong Soo Lee
Gastric cancer still is a major concern as the third most common cancer worldwide, despite declining rates of incidence in many Western countries. Helicobacter pylori (H. pylori) is the major cause of gastric carcinogenesis, and its infection insults gastric mucosa leading to the occurrence of atrophic gastritis which progress to intestinal metaplasia, dysplasia, early gastric cancer, and advanced gastric cancer consequently. This review focuses on multiple factors including microbial virulence factors, host genetic factors, and environmental factors, which can heighten the chance of occurrence of gastric adenocarcinoma due to H...
December 15, 2015: World Journal of Gastrointestinal Oncology
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