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gastritis alcohol

Mario Rodriguez-Canales, Ruben Jimenez-Rivas, Maria Margarita Canales-Martinez, Ana Judith Garcia-Lopez, Nelly Rivera-Yañez, Oscar Nieto-Yañez, Yadira Ledesma-Soto, Luvia Enid Sanchez-Torres, Miriam Rodriguez-Sosa, Luis Ignacio Terrazas, Marco Aurelio Rodriguez-Monroy
Amphipterygium adstringens is an endemic species in Mexico commonly known as "cuachalalate." Healers to treat gastritis, gastric ulcers, and gastrointestinal cancer have traditionally used the bark. We investigated the effects of alcoholic extract of A. adstringens (AaEE) in DSS-induced colitis in mice. The protective effect of AaEE was determined at 200 mg/kg by oral gavage for 10 days. We determine the effect of AaEE on clinical features (disease activity index), antioxidants, anti-inflammatory, and immunomodulatory activities in relation to the activity of SOD, CAT, and GPx, levels of proinflammatory cytokines, and changes both macroscopic and microscopic of the colonic mucosa...
2016: Mediators of Inflammation
Giuseppe Frieri, Brigida Galletti, Donatella Serva, Angelo Viscido
Alcohol, in addition to well-known damages on the liver and pancreas, produces direct and indirect injuries in the mucosa of the oesophagus, stomach, small intestine and large bowel. Different damages can be produced both when a large amount of alcohol is acutely drunk and when this is taken chronically. Almost all these lesions can be detected and treated by endoscopy as shown in the present article. When, over time, cirrhosis ensues the role of endoscopy is not different from that played with cirrhosis of different etiology...
2016: Reviews on Recent Clinical Trials
Samson Okello, Cristina Churchill, Rogers Owori, Benson Nasasira, Christine Tumuhimbise, Charles Lagoro Abonga, David Mutiibwa, David C Christiani, Kathleen E Corey
BACKGROUND: Despite the high rates and regional variation of esophageal squamous cell carcinoma (ESCC) in East Africa, the contributions of smoking and alcohol to the ESCC burden in the general population are unknown. METHODS: We conducted a case-control study of patients presenting for upper gastrointestinal endoscopic examination at Mbarara Regional Referral Hospital, Uganda. Sociodemographic data including smoking and alcohol intake were collected prior to endoscopy...
2016: BMC Cancer
J Vardy, T Keliher, J Fisher, F Ritchie, C Bell, M Chekroud, F Clarey, L Blackwood, L Barry, E Paton, A Clark, R Connelly
OBJECTIVES: Alcohol is responsible for a proportion of emergency admissions to hospital, with acute alcohol intoxication and chronic alcohol dependency (CAD) implicated. This study aims to quantify the proportion of hospital admissions through our emergency department (ED) which were thought by the admitting doctor to be (largely or partially) a result of alcohol consumption. SETTING: ED of a UK tertiary referral hospital. PARTICIPANTS: All ED admissions occurring over 14 weeks from 1 September to 8 December 2012...
2016: BMJ Open
Caroline M den Hoed, Ernst J Kuipers
Gastric cancer remains a prevalent disease worldwide with a poor prognosis. Helicobacter pylori plays a major role in gastric carcinogenesis. H. pylori colonization leads to chronic gastritis, which predisposes to atrophic gastritis, intestinal metaplasia, dysplasia, and eventually gastric cancer. Screening, treatment, and prevention of H. pylori colonization can reduce the incidence of gastric cancer. Other interventions that may yield a similar effect, although of smaller magnitude, include promotion of a healthy lifestyle including dietary measures, non-smoking, low alcohol intake, and sufficient physical activity...
July 2016: Current Gastroenterology Reports
A Schweighauser, T Francey
Poisoning with ethylene glycol as contained in antifreeze can rapidly lead to irreversible acute renal failure and other organ damage. It carries a grave prognosis unless diagnosed early and adequate treatment is initiated within 8 hours of ingestion. Toxicity of ethylene glycol is related to the production of toxic metabolites by the enzyme alcohol dehydrogenase (ADH), leading to early signs of severe polyuria (PU) and polydipsia (PD), gastritis, ataxia and central nervous depression, followed by progressive dehydration, and ultimately oligoanuric renal failure...
February 2016: Schweizer Archiv Für Tierheilkunde
P P Sanna, T Kawamura, J Chen, G F Koob, A J Roberts, L F Vendruscolo, V Repunte-Canonigo
The identification of new and more effective treatments for alcohol abuse remains a priority. Alcohol intake activates glucocorticoids, which have a key role in alcohol's reinforcing properties. Glucocorticoid effects are modulated in part by the activity of 11β-hydroxysteroid dehydrogenases (11β-HSD) acting as pre-receptors. Here, we tested the effects on alcohol intake of the 11β-HSD inhibitor carbenoxolone (CBX, 18β-glycyrrhetinic acid 3β-O-hemisuccinate), which has been extensively used in the clinic for the treatment of gastritis and peptic ulcer and is active on both 11β-HSD1 and 11β-HSD2 isoforms...
2016: Translational Psychiatry
C S Lieber
Chronic gastritis is common in the alcoholic. It is characterized by histological inflammation of the gastric mucosa and is associated with variable symptomatology. Its etiology is still the subject of debate. Recently, a new alcohol dehydrogenase isoenzyme, called sigma ADH, absent from the liver but predominant in the upper GI tract, has been fully characterized, its gene cloned, and it appears to play a major role in gastric ethanol metabolism. Indeed, it has now been established, both in vivo in experimental animals and in vitro in cultured human gastric cells, that alcohol is metabolized in the gastric mucosa, resulting in the production of acetaldehyde, a toxic metabolite...
October 1998: Addiction Biology
Svetlana Kurilovich, Anna Belkovets, Oleg Reshetnikov, Tatyana Openko, Sofja Malyutina, Ylija Ragino, Lilija Scherbakova, Marcis Leja, Lea Paloheimo, Kari Syrjänen, Mikhail Voevoda
BACKGROUND/AIM: Atrophic gastritis (AG) is the most important risk condition for gastric cancer (GC). A panel of stomach-specific serum biomarkers: pepsinogen (PG) I, pepsinogen (PG) II, gastrin-17 (G-17), and IgG antibodies to H. pylori (HP-Ab) detects the extent and grade of AG. The aim of the present study was to assess the predictive value of this 4-biomarker panel (GastroPanel, Biohit Oyj, Helsinki, Finland) in a case-control setting nested within a cohort of Caucasian population in Western Siberia...
January 2016: Anticancer Research
Hyo Jun Ahn, Dong Soo Lee
Gastric cancer still is a major concern as the third most common cancer worldwide, despite declining rates of incidence in many Western countries. Helicobacter pylori (H. pylori) is the major cause of gastric carcinogenesis, and its infection insults gastric mucosa leading to the occurrence of atrophic gastritis which progress to intestinal metaplasia, dysplasia, early gastric cancer, and advanced gastric cancer consequently. This review focuses on multiple factors including microbial virulence factors, host genetic factors, and environmental factors, which can heighten the chance of occurrence of gastric adenocarcinoma due to H...
December 15, 2015: World Journal of Gastrointestinal Oncology
Woo-Young Jeon, Mee-Young Lee, In-Sik Shin, Seong Eun Jin, Hyekyung Ha
Curcuma aromatica is an herbal medicine and traditionally used for the treatment of various diseases in Asia. We investigated the effects of C. aromatica water extract (CAW) in the stomach of rats with ethanol-induced gastritis. Gastritis was induced in rats by intragastric administration of 5 mL/kg body weight of absolute ethanol. The CAW groups were given 250 or 500 mg of extract/kg 2 h before administration of ethanol, respectively. To determine the antioxidant effects of CAW, we determined the level of lipid peroxidation, the level of reduced glutathione (GSH), the activities of catalase, degree of inflammation, and mucus production in the stomach...
2015: Evidence-based Complementary and Alternative Medicine: ECAM
Hyunsoo Chung, Young Eun Chon, Seung Up Kim, Sang Kil Lee, Kyu Sik Jung, Kwang-Hyub Han, Chae Yoon Chon
BACKGROUND: Erosive esophagitis and fatty liver share obesity and visceral fat as common critical pathogenesis. However, the relationship between the amount of hepatic fat and the severity of erosive esophagitis was not well investigated, and there is no risk estimation model for erosive esophagitis. AIM: To evaluate the relationship between the amount of hepatic fat and the severity of erosive esophagitis and then develop a risk estimation model for erosive esophagitis...
February 2016: Digestive Diseases and Sciences
Sadaf Ghajarieh Sepanlou, Fatemeh Malekzadeh, Mohsen Naghavi, Mohammad Hossein Forouzanfar, Saeid Shahraz, Maziar Moradi-Lakeh, Reza Malekzadeh, Hossein Poustchi
BACKGROUND The general pattern of epidemiologic transition from communicable to noncommunicable diseases is also observed for gastrointestinal and liver diseases (GILD), which constitute a heterogeneous array of causes of death and disability. We aimed to describe the trend of GILD in Iran based on the global burden of disease (GBD2010) study from 1990 to 2010. METHODS The trend of number of deaths, disability, adjusted life years (DALYs) and their age-standardized rates caused by 5 major GILD have been reported...
July 2015: Middle East Journal of Digestive Diseases
Ying Piao, Ying Li, Qian Xu, Jing-wei Liu, Cheng-zhong Xing, Xiao-dong Xie, Yuan Yuan
BACKGROUND: The phosphoinositide 3-kinase (PI3K)/protein kinase B (PKB, AKT)/mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in angiogenesis and cell growth, proliferation, metabolism, migration, differentiation, and apoptosis. Genetic diversity in key factors of this pathway may influence protein function and signal transduction, contributing to disease initiation and progression. Studies suggest that MTOR rs1064261 and AKT rs1130233 polymorphisms are associated with risk and/or prognosis of multiple cancer types...
2015: PloS One
Jing-Jing Jing, Li-Ping Sun, Qian Xu, Yuan Yuan
Excision repair cross-complementing group 8 (ERCC8) plays a critical role in DNA repair. Genetic polymorphisms in ERCC8 may contribute to the risk of cancer development. We selected tag single nucleotide polymorphisms (tagSNPs) in Chinese patients from the HapMap database to investigate associations with gastric cancer and its precursors. Genomic DNA was extracted from 394 controls, 394 atrophic gastritis, and 394 gastric cancer cases in northern Chinese patients, and genotypes were identified using the Sequenom MassARRAY system...
December 2015: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Soumana C Nasser, Mahmoud Slim, Jeanette G Nassif, Selim M Nasser
AIM: To investigate the influence of proton pump inhibitors (PPIs) exposure on the diagnosis of Helicobacter pylori (H. pylori) gastritis and intestinal metaplasia. METHODS: Chronic PPI use is associated with masking of H. pylori infection. Patients with H. pylori infection are predisposed to gastric and duodenal ulcers, and long-term infection with this organism has been associated with gastric mucosal atrophy and serious long-term complications, such as gastric lymphoma and adenocarcinoma...
April 21, 2015: World Journal of Gastroenterology: WJG
Hossein Ajdarkosh, Masoudreza Sohrabi, Mosayeb Moradniani, Naser Rakhshani, Masoud Sotodeh, Gholamreza Hemmasi, Mahmood Khoonsari, Mitra Ameli, Reza Malekzadeh, Farhad Zamani
Gastric cancer is one of the leading causes of cancer-related deaths worldwide. Progression of gastric cancer follows several steps from gastritis to atrophy, intestinal metaplasia, dysplasia, and finally cancer. The aim of this study was to determine the prevalence of gastric precancerous lesions and related common risk factors in a group of chronic dyspeptic patients. A total of 688 chronic dyspeptic patients older than 40 years of age were consecutively enrolled. The exclusion criteria were pregnancy, and a history of gastric cancer and gastric surgery...
September 2015: European Journal of Cancer Prevention
Bengt Zöller, Jianguang Ji, Jan Sundquist, Kristina Sundquist
Moderate alcohol consumption has been suggested to protect against venous thromboembolism (VTE). However, it is not known how alcohol abuse and its associated somatic complications affect the risk of VTE. The present study determined the risk of pulmonary embolism (PE) and deep vein thrombosis (DVT) of the lower extremities in patients with alcohol use disorders (AUDs) in Sweden. All inpatients with AUDs in 2002-2010 without a previous VTE event (72,024 patients) were matched to five controls without AUD and followed until the end of follow-up (December 31, 2010), death, emigration or a VTE event...
August 2015: Journal of Thrombosis and Thrombolysis
Doron Boltin, Yaron Niv
The gastric barrier contains several lines of defence which protect the epithelium from harmful microbes and toxins. Pre-mucosal defence mechanisms include secreted acid (HCl 0.1 mmol/L) and pepsin, which are capable of denaturing tissue. A tightly adherent mucous layer provides the next line of defence, and physically separates any potentially hazardous substance in the lumen from the mucosal surface. Apical secretion of HCO3(-) maintains a non-acidic microenvironment at the mucosal surface. Membrane-bound phospholipids repel soluble toxins, and sulphydryls scavenge reactive oxygen species...
December 2014: Best Practice & Research. Clinical Gastroenterology
D N Martínez-Carrillo, J Atrisco-Morales, R Hernández-Pando, S Reyes-Navarrete, R Betancourt-Linares, I Cruz-del Carmen, B Illades Aguiar, A Román-Román, G Fernández-Tilapa
BACKGROUND: Helicobacter pylori (H. pylori) is the main risk factor for the development of chronic gastritis, gastric ulcer, and gastric cancer. In H. pylori-infected individuals, the clinical result is dependent on various factors, among which are bacterial components, the immune response, and environmental influence. AIMS: To compare IFN-γ expression with the H. pylori vacA and cagA genotypes in patients with chronic gastritis and patients with gastric cancer...
October 2014: Revista de Gastroenterología de México
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