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https://www.readbyqxmd.com/read/27890977/health-and-socioeconomic-status-of-the-elderly-people-living-in-hilly-areas-of-pakhribas-kosi-zone-nepal
#1
Ankit Amar Gupta, Amrit Kumar Lall, Aditi Das, Anshu Saurav, Abnish Nandan, Deepa Shah, Anand Agrahari, Deepak Kumar Yadav
BACKGROUND: The rising geriatric population is facing significant health and social problems in the developing world that are impacting the quality of their lives. OBJECTIVE: The study describes the general health status and the socioeconomic characteristics of the elderly people of Pakhribas village development committee (VDC) of Eastern Nepal. MATERIALS AND METHODS: Descriptive cross-sectional study was carried out targeting the people aged 60 years and above in the sample area using a semi-structured questionnaire and convenient sampling to get the required sample size...
October 2016: Indian Journal of Community Medicine
https://www.readbyqxmd.com/read/27806647/slow-release-l-cysteine-capsule-prevents-gastric-mucosa-exposure-to-carcinogenic-acetaldehyde-results-of-a-randomised-single-blinded-cross-over-study-of-helicobacter-associated-atrophic-gastritis
#2
Per M Hellström, Panu Hendolin, Pertti Kaihovaara, Leif Kronberg, Axel Meierjohann, Anders Millerhovf, Lea Paloheimo, Heidi Sundelin, Kari Syrjänen, Dominic-Luc Webb, Mikko Salaspuro
INTRODUCTION: Helicobacter-induced atrophic gastritis with a hypochlorhydric milieu is a risk factor for gastric cancer. Microbes colonising acid-free stomach oxidise ethanol to acetaldehyde, a recognised group 1 carcinogen. OBJECTIVE: To assess gastric production of acetaldehyde and its inert condensation product, non-toxic 2-methyl-1,3-thiazolidine-4-carboxylic acid (MTCA), after alcohol intake under treatment with slow-release L-cysteine or placebo. METHODS: Seven patients with biopsy-confirmed atrophic gastritis, low serum pepsinogen and high gastrin-17 were studied in a cross-over single-blinded design...
November 3, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27635116/protective-effect-of-amphipterygium-adstringens-extract-on-dextran-sulphate-sodium-induced-ulcerative-colitis-in-mice
#3
Mario Rodriguez-Canales, Ruben Jimenez-Rivas, Maria Margarita Canales-Martinez, Ana Judith Garcia-Lopez, Nelly Rivera-Yañez, Oscar Nieto-Yañez, Yadira Ledesma-Soto, Luvia Enid Sanchez-Torres, Miriam Rodriguez-Sosa, Luis Ignacio Terrazas, Marco Aurelio Rodriguez-Monroy
Amphipterygium adstringens is an endemic species in Mexico commonly known as "cuachalalate." Healers to treat gastritis, gastric ulcers, and gastrointestinal cancer have traditionally used the bark. We investigated the effects of alcoholic extract of A. adstringens (AaEE) in DSS-induced colitis in mice. The protective effect of AaEE was determined at 200 mg/kg by oral gavage for 10 days. We determine the effect of AaEE on clinical features (disease activity index), antioxidants, anti-inflammatory, and immunomodulatory activities in relation to the activity of SOD, CAT, and GPx, levels of proinflammatory cytokines, and changes both macroscopic and microscopic of the colonic mucosa...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27515959/the-role-on-endoscopy-in-alcohol-related-diseases
#4
Giuseppe Frieri, Brigida Galletti, Donatella Serva, Angelo Viscido
Alcohol, in addition to well-known damages on the liver and pancreas, produces direct and indirect injuries in the mucosa of the oesophagus, stomach, small intestine and large bowel. Different damages can be produced both when a large amount of alcohol is acutely drunk and when this is taken chronically. Almost all these lesions can be detected and treated by endoscopy as shown in the present article. When, over time, cirrhosis ensues the role of endoscopy is not different from that played with cirrhosis of different etiology...
2016: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/27400987/population-attributable-fraction-of-esophageal-squamous-cell-carcinoma-due-to-smoking-and-alcohol-in-uganda
#5
Samson Okello, Cristina Churchill, Rogers Owori, Benson Nasasira, Christine Tumuhimbise, Charles Lagoro Abonga, David Mutiibwa, David C Christiani, Kathleen E Corey
BACKGROUND: Despite the high rates and regional variation of esophageal squamous cell carcinoma (ESCC) in East Africa, the contributions of smoking and alcohol to the ESCC burden in the general population are unknown. METHODS: We conducted a case-control study of patients presenting for upper gastrointestinal endoscopic examination at Mbarara Regional Referral Hospital, Uganda. Sociodemographic data including smoking and alcohol intake were collected prior to endoscopy...
2016: BMC Cancer
https://www.readbyqxmd.com/read/27324707/quantifying-alcohol-related-emergency-admissions-in-a-uk-tertiary-referral-hospital-a-cross-sectional-study-of-chronic-alcohol-dependency-and-acute-alcohol-intoxication
#6
J Vardy, T Keliher, J Fisher, F Ritchie, C Bell, M Chekroud, F Clarey, L Blackwood, L Barry, E Paton, A Clark, R Connelly
OBJECTIVES: Alcohol is responsible for a proportion of emergency admissions to hospital, with acute alcohol intoxication and chronic alcohol dependency (CAD) implicated. This study aims to quantify the proportion of hospital admissions through our emergency department (ED) which were thought by the admitting doctor to be (largely or partially) a result of alcohol consumption. SETTING: ED of a UK tertiary referral hospital. PARTICIPANTS: All ED admissions occurring over 14 weeks from 1 September to 8 December 2012...
2016: BMJ Open
https://www.readbyqxmd.com/read/27184043/gastric-cancer-how-can-we-reduce-the-incidence-of-this-disease
#7
REVIEW
Caroline M den Hoed, Ernst J Kuipers
Gastric cancer remains a prevalent disease worldwide with a poor prognosis. Helicobacter pylori plays a major role in gastric carcinogenesis. H. pylori colonization leads to chronic gastritis, which predisposes to atrophic gastritis, intestinal metaplasia, dysplasia, and eventually gastric cancer. Screening, treatment, and prevention of H. pylori colonization can reduce the incidence of gastric cancer. Other interventions that may yield a similar effect, although of smaller magnitude, include promotion of a healthy lifestyle including dietary measures, non-smoking, low alcohol intake, and sufficient physical activity...
July 2016: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/27145686/ethylene-glycol-poisoning-in-three-dogs-importance-of-early-diagnosis-and-role-of-hemodialysis-as-a-treatment-option
#8
A Schweighauser, T Francey
Poisoning with ethylene glycol as contained in antifreeze can rapidly lead to irreversible acute renal failure and other organ damage. It carries a grave prognosis unless diagnosed early and adequate treatment is initiated within 8 hours of ingestion. Toxicity of ethylene glycol is related to the production of toxic metabolites by the enzyme alcohol dehydrogenase (ADH), leading to early signs of severe polyuria (PU) and polydipsia (PD), gastritis, ataxia and central nervous depression, followed by progressive dehydration, and ultimately oligoanuric renal failure...
February 2016: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/26978742/11%C3%AE-hydroxysteroid-dehydrogenase-inhibition-as-a-new-potential-therapeutic-target-for-alcohol-abuse
#9
P P Sanna, T Kawamura, J Chen, G F Koob, A J Roberts, L F Vendruscolo, V Repunte-Canonigo
The identification of new and more effective treatments for alcohol abuse remains a priority. Alcohol intake activates glucocorticoids, which have a key role in alcohol's reinforcing properties. Glucocorticoid effects are modulated in part by the activity of 11β-hydroxysteroid dehydrogenases (11β-HSD) acting as pre-receptors. Here, we tested the effects on alcohol intake of the 11β-HSD inhibitor carbenoxolone (CBX, 18β-glycyrrhetinic acid 3β-O-hemisuccinate), which has been extensively used in the clinic for the treatment of gastritis and peptic ulcer and is active on both 11β-HSD1 and 11β-HSD2 isoforms...
2016: Translational Psychiatry
https://www.readbyqxmd.com/read/26735117/gastritis-in-the-alcoholic-relationship-to-gastric-alcohol-metabolism-and-helicobacter-pylori
#10
C S Lieber
Chronic gastritis is common in the alcoholic. It is characterized by histological inflammation of the gastric mucosa and is associated with variable symptomatology. Its etiology is still the subject of debate. Recently, a new alcohol dehydrogenase isoenzyme, called sigma ADH, absent from the liver but predominant in the upper GI tract, has been fully characterized, its gene cloned, and it appears to play a major role in gastric ethanol metabolism. Indeed, it has now been established, both in vivo in experimental animals and in vitro in cultured human gastric cells, that alcohol is metabolized in the gastric mucosa, resulting in the production of acetaldehyde, a toxic metabolite...
October 1998: Addiction Biology
https://www.readbyqxmd.com/read/26722050/stomach-specific-biomarkers-gastropanel-can-predict-the-development-of-gastric-cancer-in-a-caucasian-population-a-longitudinal-nested-case-control-study-in-siberia
#11
Svetlana Kurilovich, Anna Belkovets, Oleg Reshetnikov, Tatyana Openko, Sofja Malyutina, Ylija Ragino, Lilija Scherbakova, Marcis Leja, Lea Paloheimo, Kari Syrjänen, Mikhail Voevoda
BACKGROUND/AIM: Atrophic gastritis (AG) is the most important risk condition for gastric cancer (GC). A panel of stomach-specific serum biomarkers: pepsinogen (PG) I, pepsinogen (PG) II, gastrin-17 (G-17), and IgG antibodies to H. pylori (HP-Ab) detects the extent and grade of AG. The aim of the present study was to assess the predictive value of this 4-biomarker panel (GastroPanel, Biohit Oyj, Helsinki, Finland) in a case-control setting nested within a cohort of Caucasian population in Western Siberia...
January 2016: Anticancer Research
https://www.readbyqxmd.com/read/26690981/helicobacter-pylori-in-gastric-carcinogenesis
#12
REVIEW
Hyo Jun Ahn, Dong Soo Lee
Gastric cancer still is a major concern as the third most common cancer worldwide, despite declining rates of incidence in many Western countries. Helicobacter pylori (H. pylori) is the major cause of gastric carcinogenesis, and its infection insults gastric mucosa leading to the occurrence of atrophic gastritis which progress to intestinal metaplasia, dysplasia, early gastric cancer, and advanced gastric cancer consequently. This review focuses on multiple factors including microbial virulence factors, host genetic factors, and environmental factors, which can heighten the chance of occurrence of gastric adenocarcinoma due to H...
December 15, 2015: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/26483844/curcuma-aromatica-water-extract-attenuates-ethanol-induced-gastritis-via-enhancement-of-antioxidant-status
#13
Woo-Young Jeon, Mee-Young Lee, In-Sik Shin, Seong Eun Jin, Hyekyung Ha
Curcuma aromatica is an herbal medicine and traditionally used for the treatment of various diseases in Asia. We investigated the effects of C. aromatica water extract (CAW) in the stomach of rats with ethanol-induced gastritis. Gastritis was induced in rats by intragastric administration of 5 mL/kg body weight of absolute ethanol. The CAW groups were given 250 or 500 mg of extract/kg 2 h before administration of ethanol, respectively. To determine the antioxidant effects of CAW, we determined the level of lipid peroxidation, the level of reduced glutathione (GSH), the activities of catalase, degree of inflammation, and mucus production in the stomach...
2015: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/26441279/noninvasive-prediction-of-erosive-esophagitis-using-a-controlled-attenuation-parameter-cap-based-risk-estimation-model
#14
Hyunsoo Chung, Young Eun Chon, Seung Up Kim, Sang Kil Lee, Kyu Sik Jung, Kwang-Hyub Han, Chae Yoon Chon
BACKGROUND: Erosive esophagitis and fatty liver share obesity and visceral fat as common critical pathogenesis. However, the relationship between the amount of hepatic fat and the severity of erosive esophagitis was not well investigated, and there is no risk estimation model for erosive esophagitis. AIM: To evaluate the relationship between the amount of hepatic fat and the severity of erosive esophagitis and then develop a risk estimation model for erosive esophagitis...
February 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/26396715/trend-of-gastrointestinal-and-liver-diseases-in-iran-results-of-the-global-burden-of-disease-study-2010
#15
Sadaf Ghajarieh Sepanlou, Fatemeh Malekzadeh, Mohsen Naghavi, Mohammad Hossein Forouzanfar, Saeid Shahraz, Maziar Moradi-Lakeh, Reza Malekzadeh, Hossein Poustchi
BACKGROUND The general pattern of epidemiologic transition from communicable to noncommunicable diseases is also observed for gastrointestinal and liver diseases (GILD), which constitute a heterogeneous array of causes of death and disability. We aimed to describe the trend of GILD in Iran based on the global burden of disease (GBD2010) study from 1990 to 2010. METHODS The trend of number of deaths, disability, adjusted life years (DALYs) and their age-standardized rates caused by 5 major GILD have been reported...
July 2015: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/26317520/association-of-mtor-and-akt-gene-polymorphisms-with-susceptibility-and-survival-of-gastric-cancer
#16
Ying Piao, Ying Li, Qian Xu, Jing-wei Liu, Cheng-zhong Xing, Xiao-dong Xie, Yuan Yuan
BACKGROUND: The phosphoinositide 3-kinase (PI3K)/protein kinase B (PKB, AKT)/mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in angiogenesis and cell growth, proliferation, metabolism, migration, differentiation, and apoptosis. Genetic diversity in key factors of this pathway may influence protein function and signal transduction, contributing to disease initiation and progression. Studies suggest that MTOR rs1064261 and AKT rs1130233 polymorphisms are associated with risk and/or prognosis of multiple cancer types...
2015: PloS One
https://www.readbyqxmd.com/read/26130415/effect-of-ercc8-tagsnps-and-their-association-with-h-pylori-infection-smoking-and-alcohol-consumption-on-gastric-cancer-and-atrophic-gastritis-risk
#17
Jing-Jing Jing, Li-Ping Sun, Qian Xu, Yuan Yuan
Excision repair cross-complementing group 8 (ERCC8) plays a critical role in DNA repair. Genetic polymorphisms in ERCC8 may contribute to the risk of cancer development. We selected tag single nucleotide polymorphisms (tagSNPs) in Chinese patients from the HapMap database to investigate associations with gastric cancer and its precursors. Genomic DNA was extracted from 394 controls, 394 atrophic gastritis, and 394 gastric cancer cases in northern Chinese patients, and genotypes were identified using the Sequenom MassARRAY system...
December 2015: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/25914469/influence-of-proton-pump-inhibitors-on-gastritis-diagnosis-and-pathologic-gastric-changes
#18
Soumana C Nasser, Mahmoud Slim, Jeanette G Nassif, Selim M Nasser
AIM: To investigate the influence of proton pump inhibitors (PPIs) exposure on the diagnosis of Helicobacter pylori (H. pylori) gastritis and intestinal metaplasia. METHODS: Chronic PPI use is associated with masking of H. pylori infection. Patients with H. pylori infection are predisposed to gastric and duodenal ulcers, and long-term infection with this organism has been associated with gastric mucosal atrophy and serious long-term complications, such as gastric lymphoma and adenocarcinoma...
April 21, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/25793916/prevalence-of-gastric-precancerous-lesions-among-chronic-dyspeptic-patients-and-related-common-risk-factors
#19
Hossein Ajdarkosh, Masoudreza Sohrabi, Mosayeb Moradniani, Naser Rakhshani, Masoud Sotodeh, Gholamreza Hemmasi, Mahmood Khoonsari, Mitra Ameli, Reza Malekzadeh, Farhad Zamani
Gastric cancer is one of the leading causes of cancer-related deaths worldwide. Progression of gastric cancer follows several steps from gastritis to atrophy, intestinal metaplasia, dysplasia, and finally cancer. The aim of this study was to determine the prevalence of gastric precancerous lesions and related common risk factors in a group of chronic dyspeptic patients. A total of 688 chronic dyspeptic patients older than 40 years of age were consecutively enrolled. The exclusion criteria were pregnancy, and a history of gastric cancer and gastric surgery...
September 2015: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/25605687/alcohol-use-disorders-are-associated-with-venous-thromboembolism
#20
Bengt Zöller, Jianguang Ji, Jan Sundquist, Kristina Sundquist
Moderate alcohol consumption has been suggested to protect against venous thromboembolism (VTE). However, it is not known how alcohol abuse and its associated somatic complications affect the risk of VTE. The present study determined the risk of pulmonary embolism (PE) and deep vein thrombosis (DVT) of the lower extremities in patients with alcohol use disorders (AUDs) in Sweden. All inpatients with AUDs in 2002-2010 without a previous VTE event (72,024 patients) were matched to five controls without AUD and followed until the end of follow-up (December 31, 2010), death, emigration or a VTE event...
August 2015: Journal of Thrombosis and Thrombolysis
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