Paulius Valiukevičius, Justinas Mačiulaitis, Dalia Pangonytė, Vitalija Siratavičiūtė, Katarzyna Kluszczyńska, Ugnė Kuzaitytė, Rūta Insodaitė, Ieva Čiapienė, Ramunė Grigalevičiūtė, Vilma Zigmantaitė, Astra Vitkauskienė, Romaldas Mačiulaitis
This study investigates the therapeutic potential of human placental mesenchymal stem cells (P-MSCs) and their extracellular vesicles (EVs) in a murine model of acute respiratory distress syndrome (ARDS), a condition with growing relevance due to its association with severe COVID-19. We induced ARDS-like lung injury in mice using intranasal LPS instillation and evaluated histological changes, neutrophil accumulation via immunohistochemistry, bronchoalveolar lavage fluid cell count, total protein, and cytokine concentration, as well as lung gene expression changes at three time points: 24, 72, and 168 h...
November 29, 2023: Cells