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https://www.readbyqxmd.com/read/27921422/-pregestional-diabetes-mellitus-and-pregnancy
#1
Jana Bělobrádková
There is a groving number of women with pregestational diabetes mellitus. Additionaly, nowadays therapy of diabetes mellitus type I allows gravidity even in patients in whom diabetes manifested itself during their early childhood. Presence of chronic complications of diabetes increases risk of complications during pregnancy. There is incerasing number of patients with DM type II and appearence of it shifts into younger age group. Perinatal mortality and morbidity of children of mothers with pregestional diabets is higher than in comparison with common population and pregnancy planning is important measure to their decrease...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27919354/ldl-cholesterol-in-early-pregnancy-and-offspring-cardiovascular-disease-risk-factors
#2
Jacob J Christensen, Kjetil Retterstøl, Kristin Godang, Marie Cecilie Paasche Roland, Elisabeth Qvigstad, Jens Bollerslev, Thor Ueland, Tore Henriksen, Kirsten B Holven
BACKGROUND: Vast amounts of data show associations between maternal obesity, dysglycemia, diabetes, and undernutrition during pregnancy and increased cardiovascular disease risk in offspring. However, elevated maternal LDL cholesterol (LDL-C) in pregnancy and offspring cardiovascular disease (CVD) risk has scarcely been studied. OBJECTIVE: Our objective was to investigate the associations between elevated maternal LDL-C in pregnancy and CVD risk factors in 6-to-13-year-old offspring...
November 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27917777/the-identification-and-treatment-of-women-with-hyperglycaemia-in-pregnancy-an-analysis-of-individual-participant-data-systematic-reviews-meta-analyses-and-an-economic-evaluation
#3
Diane Farrar, Mark Simmonds, Susan Griffin, Ana Duarte, Debbie A Lawlor, Mark Sculpher, Lesley Fairley, Su Golder, Derek Tuffnell, Martin Bland, Fidelma Dunne, Donald Whitelaw, John Wright, Trevor A Sheldon
BACKGROUND: Gestational diabetes mellitus (GDM) is associated with a higher risk of important adverse outcomes. Practice varies and the best strategy for identifying and treating GDM is unclear. AIM: To estimate the clinical effectiveness and cost-effectiveness of strategies for identifying and treating women with GDM. METHODS: We analysed individual participant data (IPD) from birth cohorts and conducted systematic reviews to estimate the association of maternal glucose levels with adverse perinatal outcomes; GDM prevalence; maternal characteristics/risk factors for GDM; and the effectiveness and costs of treatments...
November 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27917035/polyglandular-autoimmune-syndrome-in-pregnancy-case-report
#4
Basilio Pecorino, Maria Cristina Teodoro, Paolo Scollo
Type III Polyglandular Autoimmune Syndrome is a multiple endocrine disorders disease determined by autoimmunity; it can be diagnosed if a patient is affected by Type 1 Diabetes Mellitus and another autoimmune disease, except Addison Disease, for example Autoimmune Hashimoto Thyroiditis or Celiac Disease. R.D., 34-year-old woman (gravida 2 para 1), was referred to the High Risk Pregnancy Outpatient Clinic at Cannizzaro Hospital in Catania at 8 weeks' gestation. She was affected from type III Polyglandular Autoimmune Disease (Type 1 Diabetes Mellitus, Autoimmune Hashimoto Thyroiditis and Celiac Disease)...
September 2016: Italian Journal of Gynaecology & Obstetrics: Official Publication of the Societa Italiana di Ginecologia e Ostetricia (SIGO)
https://www.readbyqxmd.com/read/27914513/fatty-acid-profile-in-cord-blood-of-neonates-born-to-optimally-controlled-gestational-diabetes-mellitus
#5
Pauline Léveillé, Jean-Luc Ardilouze, Jean-Charles Pasquier, Charles Deacon, Kevin Whittingstall, Mélanie Plourde
OBJECTIVE: To evaluate the fatty acid profile of cord blood phospholipids (PL), cholesteryl esters (CE), triglycerides (TG) and non-esterified fatty acids (NEFA) in neonates born to mothers with gestational diabetes mellitus (GDM) compared to non-diabetic mothers. METHODS: The offspring of 30 pregnant women (15 non-diabetic controls, 15 with diet- or insulin-controlled GDM) were recruited before delivery. Cord blood was collected. After lipid extraction, PL, CE, TG and NEFA were separated by thin layer chromatography and analysed by gas chromatography...
December 2016: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/27913848/increased-fetal-adiposity-prior-to-diagnosis-of-gestational-diabetes-in-south-asians-more-evidence-for-the-thin-fat-baby
#6
Hema Venkataraman, Uma Ram, Sam Craik, Anuradhai Arungunasekaran, Suresh Seshadri, Ponnusamy Saravanan
AIMS/HYPOTHESIS: Gestational diabetes mellitus (GDM) is associated with an increased future risk of obesity in the offspring. Increased adiposity has been observed in the newborns of women with GDM. Our aim was to examine early fetal adiposity in women with GDM. METHODS: Obstetric and sonographic data was collated for 153 women with GDM and 178 controls from a single centre in Chennai, India. Fetal head circumference (HC), abdominal circumference (AC), femur length (FL) and biparietal diameter (BPD) were recorded at 11, 20 and 32 weeks...
December 2, 2016: Diabetologia
https://www.readbyqxmd.com/read/27903941/prep-t1-preteen-re-education-with-parents-type-1-diabetes-feasibility-intervention-results
#7
Susan Sullivan-Bolyai, Sybil Crawford, Kim Johnson, Neesha Ramchandani, Diane Quinn, Bianca D'Alesandro, Kailyn Stern, Terry Lipman, Gail Melkus, Randi Streisand
There has been a 2% to 3% increase in Type 1 diabetes (T1D) in children below 11 years old. Preteens (9-12 years old) with T1D are often overlooked regarding future diabetes self-management (DSM) expectations because parents are still in the "driver's seat." The study purpose was to explore feasibility/ability to recruit and conduct a two-arm trial on reeducation, collaboration, and social support. One component of DSM was reviewed (hypoglycemia) with preteens (n = 22) and parents (n = 22). The experimental preteens discussed hypoglycemia management with a teen mentor and nurse educator using a human patient simulator for practice, and working collaboratively with parents...
November 2016: Journal of Family Nursing
https://www.readbyqxmd.com/read/27903516/metabolic-abnormalities-and-obesity-s-impact-on-the-risk-for-developing-preeclampsia
#8
Frank T Spradley
Preeclampsia (PE), a hypertensive disorder of pregnancy, is increasing as a major contributor to perinatal and long-term morbidity of mother and offspring. PE is thought to originate from ischemic insults in the placenta driving the release of pro-hypertensive anti-angiogenic (sFlt-1) and pro-inflammatory (TNFα) factors into the maternal circulation. While the increased incidence of PE is hypothesized to be largely due to the obesity pandemic, the mechanisms whereby obesity increases this risk are unknown...
November 30, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27903233/evaluation-of-structure-chaperone-activity-and-allergenicity-of-reduced-glycated-adduct-of-bovine-%C3%AE-casein
#9
Reza Yousefi, Leila Ferdowsi, Zohreh Tavaf, Tanaz Sadeghian, Ali Mohammad Tamaddon, Mozhgan Moghtaderi, Zahra Pourpak
Milk has a potent reducing environment with an important quantity of sugar levels. In the current study β-casein was glycated in the presence of D-glucose and sodium cyanoborohydride as a reducing agent. Then, the reduced glucitol adduct of β-casein was used for the structural and functional analyses using different spectroscopic techniques. The results of fluorescence and far ultraviolet circular dichroism assessments suggest important structural alteration upon non-enzymatic glycation of β-casein. In addition, the chaperone activity, micellization properties and antioxidant activity of this protein were altered upon glucose modification...
November 21, 2016: Protein and Peptide Letters
https://www.readbyqxmd.com/read/27888593/a-comparative-study-on-dietary-style-and-physical-activity-of-women-with-and-without-gestational-diabetes
#10
Fatereh Momeni Javid, Masoumeh Simbar, Mahrokh Dolatian, Hamid Alavi Majd, Zohre Mahmoodi
Gestational diabetes increases the risks for mother and fetus during pregnancy. As a principle of caring for diabetes, recommending patients to lose weight through more physical activities and a restrictive diet has a long history. The present study was carried out aiming at determining and comparing dietary style and physical activity in women with gestational diabetes and healthy pregnant women. This descriptive-comparative study was carried out simultaneously on 200 pregnant women (with gestational diabetes and healthy)...
October 2016: Acta Medica Iranica
https://www.readbyqxmd.com/read/27873484/pregnant-women-s-perceptions-of-gestational-weight-gain-a-systematic-review-and-meta-synthesis-of-qualitative-research
#11
REVIEW
Meredith Vanstone, Sujane Kandasamy, Mita Giacomini, Deirdre DeJean, Sarah D McDonald
Excess gestational weight gain has numerous negative health outcomes for women and children, including high blood pressure, diabetes, and cesarean section (maternal) and high birth weight, trauma at birth, and asphyxia (infants). Excess weight gain in pregnancy is associated with a higher risk of long-term obesity in both mothers and children. Despite a concerted public health effort, the proportion of pregnant women gaining weight in excess of national guidelines continues to increase. To understand this phenomenon and offer suggestions for improving interventions, we conducted a systematic review of qualitative research on pregnant women's perceptions and experiences of weight gain in pregnancy...
November 21, 2016: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/27872115/early-diagnosis-of-gestational-diabetes-mellitus-edogdm-study-a-protocol-for-a-prospective-longitudinal-cohort-study
#12
Bin Liu, Yun Xu, Ying Zhang, Jian Cai, Langhui Deng, Jianbo Yang, Yi Zhou, Yuhang Long, Jinxin Zhang, Zilian Wang
INTRODUCTION: A diagnosis of gestational diabetes mellitus (GDM) in low-risk pregnant women is based on an oral glucose tolerance test (OGTT) between 24 and 28 gestational weeks. However, there is insufficient evidence for why the test is performed in this time period. Moreover, the fetus may be exposed to hyperglycaemia prior to the current testing time frame, making earlier administration potentially advantageous. The main purpose of the present study is to investigate the GDM diagnostic value of an OGTT performed at 18-20 gestational weeks...
November 21, 2016: BMJ Open
https://www.readbyqxmd.com/read/27871759/rabbit-atg-or-basiliximab-induction-for-rapid-steroid-withdrawal-after-renal-transplantation-harmony-an-open-label-multicentre-randomised-controlled-trial
#13
Oliver Thomusch, Michael Wiesener, Mirian Opgenoorth, Andreas Pascher, Rainer Peter Woitas, Oliver Witzke, Bernd Jaenigen, Markus Rentsch, Heiner Wolters, Thomas Rath, Tülay Cingöz, Urs Benck, Bernhard Banas, Christian Hugo
BACKGROUND: Standard practice for immunosuppressive therapy after renal transplantation is quadruple therapy using antibody induction, low-dose tacrolimus, mycophenolate mofetil, and corticosteroids. Long-term steroid intake significantly increases cardiovascular risk factors with negative effects on the outcome, especially post-transplantation diabetes associated with morbidity and mortality. In this trial, we examined the efficacy and safety parameters of rapid steroid withdrawal after induction therapy with either rabbit antithymocyte globulin (rabbit ATG) or basiliximab in immunologically low-risk patients during the first year after kidney transplantation...
November 18, 2016: Lancet
https://www.readbyqxmd.com/read/27865754/perinatal-nurse-home-visiting-referral-patterns-among-women-with-diabetes-and-hypertension-in-philadelphia
#14
Joan R Bloch, Susan Zupan, Amy E McKeever, Jennifer L Barkin
OBJECTIVE: To examine access to perinatal nurse home visiting services for high-risk pregnant women who have diabetes or hypertension. DESIGN: Secondary data analysis. SETTING: Philadelphia, PA. PARTICIPANTS: Pregnant women who had a live birth during 2012 and those referred to a community-based agency for perinatal nurse home visiting because of their diagnosis of diabetes or hypertension. METHODS: Access to services was measured by examining referral information (dosage, diagnosis, gestational age at time of referral, and insurance type) retrieved from administrative logs of the community-based organization that provides perinatal home visiting to high-risk pregnant women...
November 16, 2016: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/27865017/isolated-thoughts-and-feelings-and-unsolved-concerns-adolescents-and-parents-perspectives-on-living-with-type-1-diabetes-a-qualitative-study-using-visual-storytelling
#15
Pernille Castensøe-Seidenfaden, Grete Teilmann, Finn Kensing, Eva Hommel, Birthe Susanne Olsen, Gitte Reventlov Husted
AIMS AND OBJECTIVES: To explore and describe the experiences of adolescents and their parents living with type 1 diabetes (T1DM), to identify their needs for support to improve adolescents' self-management skills in the transition from child- to adulthood. BACKGROUND: Adolescents with T1DM often experience deteriorating glycemic control and distress. Parents are important in adolescents' ability to self-manage T1DM, but they report anxiety and frustrations. A better understanding of the challenges adolescents and parents face, in relation to the daily self-management of T1DM, is important to improve clinical practice...
November 16, 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/27864335/effects-of-maternal-obesity-on-placental-function-and-fetal-development
#16
Kristy R Howell, Theresa Powell
Obesity has reached epidemic proportions and pregnancies in obese mothers have increased risk for complications including gestational diabetes, hypertensive disorders, preterm birth and caesarian section. Children born to obese mothers are at increased risk of obesity and metabolic disease and are susceptible to develop neuropsychiatric and cognitive disorders. Changes in placental function not only play a critical role in the development of pregnancy complications but may also be involved in linking maternal obesity to long-term health risks in the infant...
November 18, 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/27863534/diagnosis-a-posteriori-assessing-gestational-diabetes-screening-and-management-in-morocco
#17
Bettina Utz, Bouchra Assarag, Amina Essolbi, Amina Barkat, Yassir Ait Benkaddour, Vincent De Brouwere
BACKGROUND: In Morocco, gestational diabetes affects 1 in 10 pregnant women, but knowledge about screening and management practices outside university settings is limited. OBJECTIVE: To provide a comprehensive picture about the current situation of screening and management of gestational diabetes at different levels of care and to highlight existing challenges. DESIGN: We conducted a descriptive mixed methods study in the districts of Al Haouz and Marrakech by using both quantitative and qualitative methods, including document reviews of 369 antenatal cards and 299 hospital files, health facility inventories related to resource availability, 20 key informant interviews as well as focus group discussions with 32 pregnant women and exit interviews with 122 antenatal care (ANC) clients...
2016: Global Health Action
https://www.readbyqxmd.com/read/27862741/assessment-of-fetal-myocardial-performance-index-in-women-with-pregestational-and-gestational-diabetes-mellitus
#18
Cem Yasar Sanhal, Halil Korkut Daglar, Ozgur Kara, Dilek Uygur, Aykan Yucel
AIM: Fetal cardiac left ventricular function in pregnant women with pregestational or gestational diabetes mellitus was investigated by exploring fetal myocardial performance index (MPI) and E wave/A wave peak velocity (E/A) ratio. METHODS: Seventy pregnant women with either pregestational or gestational diabetes mellitus and with no other systemic or pregnancy related disorders were compared with 70 gestational age matched healthy controls by means of fetal left ventricular MPI and E/A ratio...
November 12, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27855754/sleep-quality-and-nocturnal-sleep-duration-in-pregnancy-and-risk-of-gestational-diabetes-mellitus
#19
Shirong Cai, Sara Tan, Peter D Gluckman, Keith M Godfrey, Seang-Mei Saw, Oon Hoe Teoh, Yap-Seng Chong, Michael J Meaney, Michael S Kramer, Joshua J Gooley
OBJECTIVE: To examine the influence of maternal sleep quality and nocturnal sleep duration on risk of gestational diabetes mellitus (GDM) in a multi-ethnic Asian population. METHODS: 686 women (376 Chinese, 186 Malay and 124 Indian) with a singleton pregnancy attended a clinic visit at 26-28 weeks of gestation as part of the Growing Up in Singapore Towards healthy Outcomes (GUSTO) mother-offspring cohort study. Self-reported sleep quality and sleep duration were assessed using the Pittsburgh Sleep Quality Index (PSQI)...
November 14, 2016: Sleep
https://www.readbyqxmd.com/read/27846825/predictors-of-nurses-and-midwives-intentions-to-provide-maternal-and-child-healthcare-services-to-adolescents-in-south-africa
#20
Kim Jonas, Priscilla Reddy, Bart van den Borne, Ronel Sewpaul, Anam Nyembezi, Pamela Naidoo, Rik Crutzen
BACKGROUND: Adolescent mothers are at a much higher risk for maternal mortality compared to mothers aged 20 years and above. Newborns born to adolescent mothers are also more likely to have low birth weight, with the risk of long-term effects such as early onset of adult diabetes than newborns of older mothers. Few studies have investigated the determinants of adequate quality maternal and child healthcare services to pregnant adolescents. This study was conducted to gain an understanding of nurses' and midwives' intentions to provide maternal and child healthcare and family planning services to adolescents in South Africa...
November 15, 2016: BMC Health Services Research
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