keyword
MENU ▼
Read by QxMD icon Read
search

Cellular respiration

keyword
https://www.readbyqxmd.com/read/28441630/winter-to-summer-change-in-vitamin-d-status-reduces-systemic-inflammation-and-bioenergetic-activity-of-human-peripheral-blood-mononuclear-cells
#1
Emily K Calton, Kevin N Keane, Raquel Raizel, Jordan Rowlands, Mario J Soares, Philip Newsholme
BACKGROUND: Vitamin D status [25(OH)D] has recently been reported to be associated with altered cellular bioenergetic profiles of peripheral blood mononuclear cells (PBMCs). No study has tracked the seasonal variation of 25(OH)D and its putative influence on whole body energy metabolism, cellular bioenergetic profiles, inflammatory markers and clinical chemistry. MATERIAL AND METHODS: Whole body energy metabolism and substrate utilisation were measured by indirect calorimetry...
April 13, 2017: Redox Biology
https://www.readbyqxmd.com/read/28431199/staphylococcus-aureus-nitric-oxide-synthase-sanos-modulates-aerobic-respiratory-metabolism-and-cell-physiology
#2
Austin B Mogen, Ronan K Carroll, Kimberly L James, Genevy Lima, Dona Silva, Jeffrey A Culver, Christopher Petucci, Lindsey N Shaw, Kelly C Rice
Nitric oxide (NO) is generated from arginine and oxygen via NO synthase (NOS). Staphylococcus aureus NOS (saNOS) has previously been shown to affect virulence and resistance to exogenous oxidative stress, yet the exact mechanism is unknown. Herein, we report a previously-undescribed role of saNOS in S. aureus aerobic physiology. Specifically, aerobic S. aureus nos mutant cultures presented with elevated endogenous reactive oxygen species (ROS) and superoxide levels, as well as increased membrane potential, increased respiratory dehydrogenase activity, and slightly elevated oxygen consumption...
April 21, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28429317/biochemistry-and-physiology-of-reactive-oxygen-species-in-euglena
#3
Takahiro Ishikawa, Shun Tamaki, Takanori Maruta, Shigeru Shigeoka
Reactive oxygen species (ROS) such as superoxide and hydrogen peroxide are by-products of various metabolic processes in aerobic organisms including Euglena. Chloroplasts and mitochondria are the main sites of ROS generation by photosynthesis and respiration, respectively, through the active electron transport chain. An efficient antioxidant network is required to maintain intracellular ROS pools at optimal conditions for redox homeostasis. A comparison with the networks of plants and animals revealed that Euglena has acquired some aspects of ROS metabolic process...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28427248/caloric-restriction-induced-extension-of-chronological-lifespan-requires-intact-respiration-in-budding-yeast
#4
Young-Yon Kwon, Sung-Keun Lee, Cheol-Koo Lee
Caloric restriction (CR) has been shown to extend lifespan and prevent cellular senescence in various species ranging from yeast to humans. Many effects of CR may contribute to extend lifespan. Specifically, CR prevents oxidative damage from reactive oxygen species (ROS) by enhancing mitochondrial function. In this study, we characterized 33 single electron transport chain (ETC) gene-deletion strains to identify CR-induced chronological lifespan (CLS) extension mechanisms. Interestingly, defects in 17 of these 33 ETC genedeleted strains showed loss of both respiratory function and CR-induced CLS extension...
April 20, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/28424622/pravastatin-chronic-treatment-sensitizes-hypercholesterolemic-mice-muscle-to-mitochondrial-permeability-transition-protection-by-creatine-or-coenzyme-q10
#5
Estela N B Busanello, Ana C Marques, Noelia Lander, Diogo N de Oliveira, Rodrigo R Catharino, Helena C F Oliveira, Anibal E Vercesi
Statins are efficient cholesterol-lowering medicines utilized worldwide. However, 10% of patients suffer from adverse effects specially related to skeletal muscle function. Pro- or anti-oxidant effects of statins have been reported. Here we hypothesized that statins induce muscle mitochondrial oxidative stress leading to mitochondrial permeability transition (MPT) which may explain statin muscle toxicity. Thus, our aims were to investigate the effects of statin chronic treatment on muscle mitochondrial respiration rates, MPT and redox state indicators in the context of hypercholesterolemia...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28415782/glutaminase-inhibitor-cb-839-synergizes-with-carfilzomib-in-resistant-multiple-myeloma-cells
#6
Ravyn M Thompson, Dominik Dytfeld, Leticia Reyes, Reeder M Robinson, Brittany Smith, Yefim Manevich, Andrzej Jakubowiak, Mieczyslaw Komarnicki, Anna Przybylowicz-Chalecka, Tomasz Szczepaniak, Amit K Mitra, Brian G Van Ness, Magdalena Luczak, Nathan G Dolloff
Curative responses in the treatment of multiple myeloma (MM) are limited by the emergence of therapeutic resistance. To address this problem, we set out to identify druggable mechanisms that convey resistance to proteasome inhibitors (PIs; e.g., bortezomib), which are cornerstone agents in the treatment of MM. In isogenic pairs of PI sensitive and resistant cells, we observed stark differences in cellular bioenergetics between the divergent phenotypes. PI resistant cells exhibited increased mitochondrial respiration driven by glutamine as the principle fuel source...
March 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28414727/trypanosoma-brucei-tbif1-inhibits-the-essential-f1-atpase-in-the-infectious-form-of-the-parasite
#7
Brian Panicucci, Ondřej Gahura, Alena Zíková
The mitochondrial (mt) FoF1-ATP synthase of the digenetic parasite, Trypanosoma brucei, generates ATP during the insect procyclic form (PF), but becomes a perpetual consumer of ATP in the mammalian bloodstream form (BF), which lacks a canonical respiratory chain. This unconventional dependence on FoF1-ATPase is required to maintain the essential mt membrane potential (Δψm). Normally, ATP hydrolysis by this rotary molecular motor is restricted to when eukaryotic cells experience sporadic hypoxic conditions, during which this compulsory function quickly depletes the cellular ATP pool...
April 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28412346/superoxide-is-the-critical-driver-of-dopal-autoxidation-lysyl-adduct-formation-and-crosslinking-of-%C3%AE-synuclein
#8
Jon W Werner-Allen, Rodney L Levine, Ad Bax
Parkinson's disease has long been associated with redox imbalance and oxidative stress in dopaminergic neurons. The catecholaldehyde hypothesis proposes that 3,4-dihydroxyphenylacetaldehyde (DOPAL), an obligate product of dopamine catabolism, is a central nexus in a network of pathways leading to disease-state neurodegeneration, owing to its toxicity and potent ability to oligomerize α-synuclein, the main component of protein aggregates in Lewy bodies. In this work we examine the connection between reactive oxygen species and DOPAL autoxidation...
April 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28407586/physiological-and-biochemical-impacts-induced-by-mercury-pollution-and-seawater-acidification-in-hediste-diversicolor
#9
Rosa Freitas, Lucia de Marchi, Anthony Moreira, João L T Pestana, Frederick J Wrona, Etelvina Figueira, Amadeu M V M Soares
The present study evaluated the impacts of predicted seawater acidification and Hg pollution, when stressors were acting alone and in combination, on the polychaete Hediste diversicolor. Polychaetes were exposed during 28days to low pH (7.5), Hg (5μg/L) and pH7.5+Hg, and physiological alterations (respiration rate), biochemical markers related to metabolic potential (glycogen and protein content, electron transport system activity) and oxidative status (activity of antioxidant and biotransformation enzymes, lipid peroxidation) were evaluated...
April 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28404596/tumor-necrosis-factor-a-promotes-phosphoinositide-3-kinase-enhancer-a-and-amp-activated-protein-kinase-interaction-to-suppress-lipid-oxidation-in-skeletal-muscle
#10
Margaret Chui Ling Tse, Oana Herlea-Pana, Daniel Brobst, Xiuying Yang, John Wood, Xiang Hu, Zhixue Liu, Chi Wai Lee, Aung Moe Zaw, Billy K C Chow, Keqiang Ye, Chi Bun Chan
Tumor necrosis factor α (TNFα) is an inflammatory cytokine that plays a central role in obesity-induced insulin resistance. It also controls cellular lipid metabolism but the underlining mechanism is poorly understood. We report here that phosphoinositide 3-kinase enhancer A (PIKE-A) is a novel effector of TNFα to facilitate its metabolic modulation in the skeletal muscle. Depletion of PIKE-A in C2C12 myotubes diminished the inhibitory activities of TNFα on mitochondrial respiration and lipid oxidation, whereas PIKE-A overexpression exacerbated these cellular responses...
April 12, 2017: Diabetes
https://www.readbyqxmd.com/read/28404377/h2s-induced-s-sulfhydration-of-lactate-dehydrogenase-a-ldha-stimulates-cellular-bioenergetics-in-hct116-colon-cancer-cells
#11
Ashley A Untereiner, Gabor Oláh, Katalin Módis, Mark R Hellmich, Csaba Szabo
Cystathionine-β-synthase (CBS) is upregulated and hydrogen sulfide (H2S) production is increased in colon cancer cells. The functional consequence of this response is stimulation of cellular bioenergetics and tumor growth and proliferation. Lactate dehydrogenase A (LDHA) is also upregulated in various colon cancer cells and has been previously implicated in tumor cell bioenergetics and proliferation. In the present study, we sought to determine the potential interaction between the H2S pathway and LDH activity in the control of bioenergetics and proliferation of colon cancer, using the colon cancer line HCT116...
April 9, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28401922/the-phosphatidylcholine-transfer-protein-stard7-is-required-for-mitochondrial-and-epithelial-cell-homeostasis
#12
Li Yang, Cheng-Lun Na, Shiyu Luo, David Wu, Simon Hogan, Taosheng Huang, Timothy E Weaver
Mitochondria synthesize select phospholipids but lack the machinery for synthesis of the most abundant mitochondrial phospholipid, phosphatidylcholine (PC). Although the phospholipid transfer protein Stard7 promotes uptake of PC by mitochondria, the importance of this pathway for mitochondrial and cellular homeostasis represents a significant knowledge gap. Haploinsufficiency for Stard7 is associated with significant exacerbation of allergic airway disease in mice, including an increase in epithelial barrier permeability...
April 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28389626/metabolomics-for-biomarker-discovery-in-the-diagnosis-prognosis-survival-and-recurrence-of-colorectal-cancer-a-systematic-review
#13
Fan Zhang, Yuanyuan Zhang, Weiwei Zhao, Kui Deng, Zhuozhong Wang, Chunyan Yang, Libing Ma, Margarita S Openkova, Yan Hou, Kang Li
Colorectal cancer (CRC) remains an incurable disease. There are no effective noninvasive techniques that have achieved colorectal cancer (CRC) diagnosis, prognosis, survival and recurrence in clinic. To investigate colorectal cancer metabolism, we perform an electronic literature search, from 1998 to January 2016, for studies evaluating the metabolomic profile of patients with CRC regarding the diagnosis, recurrence, prognosis/survival, and systematically review the twenty-three literatures included. QUADOMICS tool was used to assess the quality of them...
March 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28386962/comparative-analyses-of-h2-photoproduction-in-magnesium-and-sulfur-starved-chlamydomonas-reinhardtii-cultures
#14
Alena A Volgusheva, Martina Jokel, Yagut Allahverdiyeva, Galina P Kukarskikh, Eugeni P Lukashev, Maya D Lambreva, Tatayana E Krendeleva, Taras K Antal
Magnesium (Mg)-deprived Chlamydomonas reinhardtii cells are capable to sustain hydrogen (H2 ) photoproduction at relatively high PSII activity levels for an extended time period as compared with sulfur (S)-deprived cells. Herein, we present a comparative study of H2 photoproduction induced by Mg and S shortage to unravel the specific rearrangements of photosynthetic machinery and cell metabolism occurring under the two deprivation protocols. The exhaustive analysis of photosynthetic activity and regulatory pathways, respiration, and starch metabolism revealed the specific rearrangements of photosynthetic machinery and cellular metabolism, which occur under the two deprivation conditions...
April 7, 2017: Physiologia Plantarum
https://www.readbyqxmd.com/read/28386307/sulforaphane-protects-against-high-cholesterol-induced-mitochondrial-bioenergetics-impairments-inflammation-and-oxidative-stress-and-preserves-pancreatic-%C3%AE-cells-function
#15
Catalina Carrasco-Pozo, Kah Ni Tan, Martin Gotteland, Karin Borges
Cholesterol plays an important role in inducing pancreatic β-cell dysfunction, leading to an impaired insulin secretory response to glucose. This study aimed to determine the protective effects of sulforaphane, a natural isothiocyanate Nrf2-inducer, against cholesterol-induced pancreatic β-cells dysfunction, through molecular and cellular mechanisms involving mitochondrial bioenergetics. Sulforaphane prevented cholesterol-induced alterations in the coupling efficiency of mitochondrial respiration, improving ATP turnover and spare capacity, and averted the impairment of the electron flow at complexes I, II, and IV...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28383716/essential-role-for-non-canonical-poly-a-polymerase-gld4-in-cytoplasmic-polyadenylation-and-carbohydrate-metabolism
#16
Jihae Shin, Ki Young Paek, Maria Ivshina, Emily E Stackpole, Joel D Richter
Regulation of gene expression at the level of cytoplasmic polyadenylation is important for many biological phenomena including cell cycle progression, mitochondrial respiration, and learning and memory. GLD4 is one of the non-canonical poly(A) polymerases that regulates cytoplasmic polyadenylation-induced translation, but its target mRNAs and role in cellular physiology is not well known. To assess the full panoply of mRNAs whose polyadenylation is controlled by GLD4, we performed an unbiased whole genome-wide screen using poy(U) chromatography and thermal elution...
April 5, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28382170/obatoclax-and-ly3009120-efficiently-overcome-vemurafenib-resistance-in-differentiated-thyroid-cancer
#17
Wei-Jun Wei, Zhen-Kui Sun, Chen-Tian Shen, Hong-Jun Song, Xin-Yun Zhang, Zhong-Ling Qiu, Quan-Yong Luo
Although the prognosis of differentiated thyroid cancer (DTC) is relatively good, 30-40% of patients with distant metastases develop resistance to radioactive iodine therapy due to tumor dedifferentiation. For DTC patients harboring BRAF(V600E) mutation, Vemurafenib, a BRAF kinase inhibitor, has dramatically changed the therapeutic landscape, but side effects and drug resistance often lead to termination of the single agent treatment. In the present study, we showed that either LY3009120 or Obatoclax (GX15-070) efficiently inhibited cell cycle progression and induced massive death of DTC cells...
2017: Theranostics
https://www.readbyqxmd.com/read/28376491/glycobiology-modifications-in-intratumoral-hypoxia-the-breathless-side-of-glycans-interaction
#18
Antônio F Silva-Filho, Wanessa L B Sena, Luiza R A Lima, Lidiane V N Carvalho, Michelly C Pereira, Lucas G S Santos, Renata V C Santos, Lucas B Tavares, Maira G R Pitta, Moacyr J B M Rêgo
Post-translational and co-translational enzymatic addition of glycans (glycosylation) to proteins, lipids, and other carbohydrates, is a powerful regulator of the molecular machinery involved in cell cycle, adhesion, invasion, and signal transduction, and is usually seen in both in vivo and in vitro cancer models. Glycosyltransferases can alter the glycosylation pattern of normal cells, subsequently leading to the establishment and progression of several diseases, including cancer. Furthermore, a growing amount of research has shown that different oxygen tensions, mainly hypoxia, leads to a markedly altered glycosylation, resulting in altered glycan-receptor interactions...
April 3, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28373404/precancer-atlas-to-drive-precision-prevention-trials
#19
Avrum Spira, Matthew B Yurgelun, Ludmil Alexandrov, Anjana Rao, Rafael Bejar, Kornelia Polyak, Marios Giannakis, Ali Shilatifard, Olivera J Finn, Madhav Dhodapkar, Neil E Kay, Esteban Braggio, Eduardo Vilar, Sarah A Mazzilli, Timothy R Rebbeck, Judy E Garber, Victor E Velculescu, Mary L Disis, Douglas C Wallace, Scott M Lippman
Cancer development is a complex process driven by inherited and acquired molecular and cellular alterations. Prevention is the holy grail of cancer elimination, but making this a reality will take a fundamental rethinking and deep understanding of premalignant biology. In this Perspective, we propose a national concerted effort to create a Precancer Atlas (PCA), integrating multi-omics and immunity - basic tenets of the neoplastic process. The biology of neoplasia caused by germline mutations has led to paradigm-changing precision prevention efforts, including: tumor testing for mismatch repair (MMR) deficiency in Lynch syndrome establishing a new paradigm, combinatorial chemoprevention efficacy in familial adenomatous polyposis (FAP), signal of benefit from imaging-based early detection research in high-germline risk for pancreatic neoplasia, elucidating early ontogeny in BRCA1-mutation carriers leading to an international breast cancer prevention trial, and insights into the intricate germline-somatic-immunity interaction landscape...
April 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/28371310/sequential-bioavailability-of-sedimentary-organic-matter-to-heterotrophic-bacteria
#20
Nagissa Mahmoudi, Steven R Beaupré, Andrew D Steen, Ann Pearson
Aquatic sediments harbor diverse microbial communities that mediate organic matter degradation and influence biogeochemical cycles. The pool of bioavailable carbon continuously changes as a result of abiotic processes and microbial activity. It remains unclear how microbial communities respond to heterogeneous organic matrices and how this ultimately affects heterotrophic respiration. To explore the relationships between the degradation of mixed carbon substrates and microbial activity, we incubated batches of organic-rich sediments in a novel bioreactor (IsoCaRB) that permitted continuous observations of CO2 production rates, as well as sequential sampling of isotopic signatures (δ(13) C, Δ(14) C), microbial community structure and diversity, and extracellular enzyme activity...
April 3, 2017: Environmental Microbiology
keyword
keyword
88413
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"