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david ludwig

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https://www.readbyqxmd.com/read/29198827/systematic-three-dimensional-coculture-rapidly-recapitulates-interactions-between-human-neurons-and-astrocytes
#1
Robert Krencik, Kyounghee Seo, Jessy V van Asperen, Nupur Basu, Caroline Cvetkovic, Saba Barlas, Robert Chen, Connor Ludwig, Chao Wang, Michael E Ward, Li Gan, Philip J Horner, David H Rowitch, Erik M Ullian
Human astrocytes network with neurons in dynamic ways that are still poorly defined. Our ability to model this relationship is hampered by the lack of relevant and convenient tools to recapitulate this complex interaction. To address this barrier, we have devised efficient coculture systems utilizing 3D organoid-like spheres, termed asteroids, containing pre-differentiated human pluripotent stem cell (hPSC)-derived astrocytes (hAstros) combined with neurons generated from hPSC-derived neural stem cells (hNeurons) or directly induced via Neurogenin 2 overexpression (iNeurons)...
November 27, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/29178263/characterizing-the-free-volume-of-ultrahigh-molecular-weight-polyethylene-to-predict-diffusion-coefficients-in-orthopedic-liners
#2
Kyle B Ludwig, Vaishnavi Chandrasekar, David M Saylor, Douglas W Van Citters, Steven D Reinitz, Christopher Forrey, Martin K McDermott, Samanthi Wickramasekara, Dustin W Janes
Liners used in orthopedic devices are often made from ultrahigh molecular weight polyethylene (UHMWPE). A general predictive capability for transport coefficients of small molecules in UHMWPE does not exist, making it difficult to assess properties associated with leaching or uptake of small molecules. To address this gap, we describe here how a form of the Vrentas-Duda free volume model can be used to predict upper-bound diffusion coefficients (D) of arbitrary molecules within UHMWPE on the basis of their size and shape...
November 27, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29138631/sarc006-phase-ii-trial-of-chemotherapy-in-sporadic-and-neurofibromatosis-type-1-associated-chemotherapy-naive-malignant-peripheral-nerve-sheath-tumors
#3
Christine S Higham, Seth M Steinberg, Eva Dombi, Arie Perry, Lee J Helman, Scott M Schuetze, Joseph A Ludwig, Arthur Staddon, Mohammed M Milhem, Daniel Rushing, Robin L Jones, Michael Livingston, Stewart Goldman, Christopher Moertel, Lars Wagner, David Janhofer, Christina M Annunziata, Denise Reinke, Lauren Long, David Viskochil, Larry Baker, Brigitte C Widemann
Background: Worse chemotherapy response for neurofibromatosis type 1- (NF1-) associated compared to sporadic malignant peripheral nerve sheath tumors (MPNST) has been reported. Methods: We evaluated the objective response (OR) rate of patients with AJCC Stage III/IV chemotherapy-naive NF1 MPNST versus sporadic MPNST after 4 cycles of neoadjuvant chemotherapy, 2 cycles of ifosfamide/doxorubicin, and 2 cycles of ifosfamide/etoposide. A Simon optimal two-stage design was used (target response rate 40%)...
2017: Sarcoma
https://www.readbyqxmd.com/read/29118063/dietary-fat-friend-or-foe
#4
Cara B Ebbeling, Ian S Young, Alice H Lichtenstein, David S Ludwig, Michelle McKinley, Rafael Perez-Escamilla, Eric Rimm
No abstract text is available yet for this article.
November 8, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29073604/cardiac-mesenchymal-stem-cells-proliferate-early-in-the-ischemic-heart
#5
Christian Klopsch, Anna Skorska, Marion Ludwig, Ralf Gaebel, Heiko Lemcke, Gabriela Kleiner, Martin Beyer, Brigitte Vollmar, Robert David, Gustav Steinhoff
BACKGROUND/PURPOSE: Cardiac mesenchymal stem cells (MSCs) could stimulate cell-specific regenerative mechanisms after myocardial infarction (MI) depending on spatial origin, distribution, and niche regulation. We aimed at identifying and isolating tissue-specific cardiac MSCs that could contribute to regeneration. METHODS: Following permanent ligation of the left anterior descending coronary artery in rats (n = 16), early cardiac tissues and cardiac mononuclear cells (MNCs) were analyzed by immunohistology, confocal laser scanning microscopy, and flow cytometry, respectively...
October 26, 2017: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/29070530/the-histone-demethylase-jumonji-domain-containing-protein-3-jmjd3-regulates-fibroblast-activation-in-systemic-sclerosis
#6
Christina Bergmann, Amelie Brandt, Benita Merlevede, Ludwig Hallenberger, Clara Dees, Thomas Wohlfahrt, Sebastian Pötter, Yun Zhang, Chih-Wei Chen, Tatiana Mallano, Ruifang Liang, Rosebeth Kagwiria, Alexander Kreuter, Ioanna Pantelaki, Aline Bozec, David Abraham, Ralf Rieker, Andreas Ramming, Oliver Distler, Georg Schett, Jörg H W Distler
OBJECTIVES: Systemic sclerosis (SSc) fibroblasts remain activated even in the absence of exogenous stimuli. Epigenetic alterations are thought to play a role for this endogenous activation. Trimethylation of histone H3 on lysine 27 (H3K27me3) is regulated by Jumonji domain-containing protein 3 (JMJD3) and ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX) in a therapeutically targetable manner. The aim of this study was to explore H3K27me3 demethylases as potential targets for the treatment of fibrosis...
October 25, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29062620/ludwig-s-angina
#7
Stella Pak, David Cha, Chloe Meyer, Christine Dee, Adam Fershko
Ludwig's angina is a diffuse cellulitis in the submandibular, sublingual, and submental spaces, characterized by its propensity to spread rapidly to the surrounding tissues. Early recognition and treatment for Ludwig's angina are of paramount importance due to the myriad of complications that can occur in association with Ludwig's angina. Known complications of Ludwig's angina include carotid arterial rupture or sheath abscess, thrombophlebitis of the internal jugular vein, mediastinitis, empyema, pericardial effusion, osteomyelitis of the mandible, subphrenic abscess, aspiration pneumonia, and pleural effusion...
August 21, 2017: Curēus
https://www.readbyqxmd.com/read/29041870/fluid-biomarker-and-electrophysiological-outcome-measures-for-progressive-ms-trials
#8
Christian Barro, Letizia Leocani, David Leppert, Giancarlo Comi, Ludwig Kappos, Jens Kuhle
Progressive multiple sclerosis (MS) is characterized by insidious clinical worsening that is difficult to accurately quantify and predict. Biofluid markers and electrophysiological measures are potential candidate outcome measures in clinical trials, allowing the quantification of nervous damage occurring in the disease. Neurofilaments are highly specific neuronal proteins. They may have come closest to such applications by their higher concentrations repeatedly demonstrated in cerebrospinal fluid (CSF) in all stages of MS, during relapses, their responsiveness to disease-modifying treatments in relapsing and progressive MS and their associations with measures of inflammatory and degenerative magnetic resonance imaging (MRI) outcomes...
October 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29035042/nmrml-a-community-supported-open-data-standard-for-the-description-storage-and-exchange-of-nmr-data
#9
Daniel Schober, Daniel Jacob, Michael Wilson, Joseph A Cruz, Ana Marcu, Jason R Grant, Annick Moing, Catherine Deborde, Luis F de Figueiredo, Kenneth Haug, Philippe Rocca-Serra, John M Easton, Timothy M D Ebbels, Jie Hao, Christian Ludwig, Ulrich L Günther, Antonio Rosato, Matthias S Klein, Ian Lewis, Claudio Luchinat, Andrew R Jones, Arturas Grauslys, Martin Larralde, Masashi Yokochi, Naohiro Kobayashi, Andrea Porzel, Julian Griffin, Mark R Viant, David S Wishart, Christoph Steinbeck, Reza M Salek, Steffen Neumann
NMR is a widely used analytical technique with a growing number of repositories available. As a result, demands for a vendor-agnostic, open data format for long-term archiving of NMR data have emerged with the aim to ease and encourage sharing, comparison and reuse of NMR data. Here we present nmrML, an open XML-based exchange and storage format for NMR spectral data. The nmrML format is intended to be fully compatible with existing NMR data for chemical, biochemical and metabolomics experiments. nmrML can capture raw NMR data, spectral data acquisition parameters and, where available, spectral metadata such as chemical structures associated with spectral assignments...
October 16, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29033282/character-strengths-of-individuals-with-first-episode-psychosis-in-individual-resiliency-training
#10
Julia Browne, Sue E Estroff, Kelsey Ludwig, Carrington Merritt, Piper Meyer-Kalos, Kim T Mueser, Jennifer D Gottlieb, David L Penn
Positive psychology interventions that integrate a person's strengths into treatment result in improvements in life satisfaction and well-being. Character strengths classified within six core virtues (wisdom/knowledge, courage, humanity, justice, temperance, and transcendence) have been the subject of substantial research. Though a number of studies have been conducted in the general population, little is known about the character strengths of individuals with first episode psychosis (FEP). Moreover, positive psychology principles, in particular a focus on personal strengths, have been increasingly integrated into FEP treatment and was a core component of Individual Resiliency Training (IRT), the individual therapy component of NAVIGATE tested in the Recovery After an Initial Schizophrenia Episode Early Treatment Program...
October 12, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28989726/carbohydrate-last-meal-pattern-lowers-postprandial-glucose-and-insulin-excursions-in-type-2-diabetes
#11
Alpana P Shukla, Jeselin Andono, Samir H Touhamy, Anthony Casper, Radu G Iliescu, Elizabeth Mauer, Yuan Shan Zhu, David S Ludwig, Louis J Aronne
BACKGROUND: There are limited data regarding the timing of carbohydrate ingestion during a meal and postprandial glucose regulation. METHODS: Sixteen subjects with type 2 diabetes mellitus (T2DM) consumed the same meal on 3 days in random order: carbohydrate first, followed 10 min later by protein and vegetables; protein and vegetables first, followed 10 min later by carbohydrate; or all components together. Blood was sampled for glucose, insulin, glucagon-like peptide-1 (GLP-1), and glucagon measurements at baseline (just before meal ingestion) and subsequently at 30 min intervals up to 180 min...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28970902/double-quick-double-click-reversible-peptide-stapling
#12
Claire M Grison, George M Burslem, Jennifer A Miles, Ludwig K A Pilsl, David J Yeo, Zeynab Imani, Stuart L Warriner, Michael E Webb, Andrew J Wilson
The development of constrained peptides for inhibition of protein-protein interactions is an emerging strategy in chemical biology and drug discovery. This manuscript introduces a versatile, rapid and reversible approach to constrain peptides in a bioactive helical conformation using BID and RNase S peptides as models. Dibromomaleimide is used to constrain BID and RNase S peptide sequence variants bearing cysteine (Cys) or homocysteine (hCys) amino acids spaced at i and i + 4 positions by double substitution...
July 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28954635/towards-new-recommendations-to-reduce-the-burden-of-alcohol-induced-hypertension-in-the-european-union
#13
Jürgen Rehm, Peter Anderson, Jose Angel Arbesu Prieto, Iain Armstrong, Henri-Jean Aubin, Michael Bachmann, Nuria Bastida Bastus, Carlos Brotons, Robyn Burton, Manuel Cardoso, Joan Colom, Daniel Duprez, Gerrit Gmel, Antoni Gual, Ludwig Kraus, Reinhold Kreutz, Helena Liira, Jakob Manthey, Lars Møller, Ľubomír Okruhlica, Michael Roerecke, Emanuele Scafato, Bernd Schulte, Lidia Segura-Garcia, Kevin David Shield, Cristina Sierra, Konstantin Vyshinskiy, Marcin Wojnar, José Zarco
BACKGROUND: Hazardous and harmful alcohol use and high blood pressure are central risk factors related to premature non-communicable disease (NCD) mortality worldwide. A reduction in the prevalence of both risk factors has been suggested as a route to reach the global NCD targets. This study aims to highlight that screening and interventions for hypertension and hazardous and harmful alcohol use in primary healthcare can contribute substantially to achieving the NCD targets. METHODS: A consensus conference based on systematic reviews, meta-analyses, clinical guidelines, experimental studies, and statistical modelling which had been presented and discussed in five preparatory meetings, was undertaken...
September 28, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28950068/reply-to-letter-regarding-the-fulfil-trial
#14
David A Lipson, Helen Barnacle, Ruby Birk, Noushin Brealey, Nicholas Locantore, David A Lomas, Andrea Ludwig-Sengpiel, Rajat Mohindra, Maggie Tabberer, Chang-Qing Zhu, Steven J Pascoe
No abstract text is available yet for this article.
September 26, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28929440/the-influence-of-visual-flow-and-perceptual-load-on-locomotion-speed
#15
Casimir J H Ludwig, Nicholas Alexander, Kate L Howard, Alicja A Jedrzejewska, Isha Mundkur, David Redmill
Visual flow is used to perceive and regulate movement speed during locomotion. We assessed the extent to which variation in flow from the ground plane, arising from static visual textures, influences locomotion speed under conditions of concurrent perceptual load. In two experiments, participants walked over a 12-m projected walkway that consisted of stripes that were oriented orthogonal to the walking direction. In the critical conditions, the frequency of the stripes increased or decreased. We observed small, but consistent effects on walking speed, so that participants were walking slower when the frequency increased compared to when the frequency decreased...
September 19, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/28881418/population-pharmacokinetic-evaluation-and-missed-dose-simulations-for-eslicarbazepine-acetate-monotherapy-in-patients-with-partial-onset-seizures
#16
Soujanya Sunkaraneni, David Blum, Elizabeth Ludwig, Vaishali Chudasama, Jill Fiedler-Kelly, Marketa Marvanova, Jacquelyn Bainbridge, Luann Phillips
Given the potential consequences of antiepileptic therapy nonadherence, missed-dose scenarios of 12- to 48-hour dose delays (4-hour intervals) for eslicarbazepine acetate monotherapy were evaluated using simulated plasma concentrations of a population pharmacokinetic model (representing 493 subjects). When 1600-mg doses were delayed 12 to <16 or 36 to <44 hours, simulations showed immediate administration of 1600 mg followed by the same dose at the scheduled time maintained plasma concentrations within the target concentration range...
September 7, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/28826205/construction-of-recombinant-pdu-metabolosome-shells-for-small-molecule-production-in-corynebacterium-glutamicum
#17
Isabel Huber, David J Palmer, Kira N Ludwig, Ian R Brown, Martin J Warren, Julia Frunzke
Bacterial microcompartments have significant potential in the area of industrial biotechnology for the production of small molecules, especially involving metabolic pathways with toxic or volatile intermediates. Corynebacterium glutamicum is an established industrial workhorse for the production of amino acids and has been investigated for the production of diamines, dicarboxylic acids, polymers and biobased fuels. Herein, we describe components for the establishment of bacterial microcompartments as production chambers in C...
September 1, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28764526/high-throughput-heterodyne-thermoreflectance-application-to-thermal-conductivity-measurements-of-a-fe-si-ge-thin-film-alloy-library
#18
Quentin d'Acremont, Gilles Pernot, Jean-Michel Rampnoux, Andrej Furlan, David Lacroix, Alfred Ludwig, Stefan Dilhaire
A High-Throughput Time-Domain ThermoReflectance (HT-TDTR) technique was developed to perform fast thermal conductivity measurements with minimum user actions required. This new setup is based on a heterodyne picosecond thermoreflectance system. The use of two different laser oscillators has been proven to reduce the acquisition time by two orders of magnitude and avoid the experimental artefacts usually induced by moving the elements present in TDTR systems. An amplitude modulation associated to a lock-in detection scheme is included to maintain a high sensitivity to thermal properties...
July 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28761328/training-time-and-quality-of-smartphone-based-anterior-segment-screening-in-rural-india
#19
Cassie A Ludwig, Megan R Newsom, Alexandre Jais, David J Myung, Somasheila I Murthy, Robert T Chang
OBJECTIVE: We aimed at evaluating the ability of individuals without ophthalmologic training to quickly capture high-quality images of the cornea by using a smartphone and low-cost anterior segment imaging adapter (the "EyeGo" prototype). METHODS: Seven volunteers photographed 1,502 anterior segments from 751 high school students in Varni, India, by using an iPhone 5S with an attached EyeGo adapter. Primary outcome measures were median photograph quality of the cornea and anterior segment of the eye (validated Fundus Photography vs Ophthalmoscopy Trial Outcomes in the Emergency Department [FOTO-ED] study; 1-5 scale; 5, best) and the time required to take each photograph...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28730465/time-varying-decision-boundaries-insights-from-optimality-analysis
#20
Gaurav Malhotra, David S Leslie, Casimir J H Ludwig, Rafal Bogacz
The most widely used account of decision-making proposes that people choose between alternatives by accumulating evidence in favor of each alternative until this evidence reaches a decision boundary. It is frequently assumed that this decision boundary stays constant during a decision, depending on the evidence collected but not on time. Recent experimental and theoretical work has challenged this assumption, showing that constant decision boundaries are, in some circumstances, sub-optimal. We introduce a theoretical model that facilitates identification of the optimal decision boundaries under a wide range of conditions...
July 20, 2017: Psychonomic Bulletin & Review
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