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david ludwig

Hussein Kanso, María Begoña González García, Laura Fernández Llano, Su Ma, Roland Ludwig, Pablo Fanjul Bolado, David Hernández Santos
A new Screen-printed electrodes (SPE) integrated in one channel flow-cell was developed. The one channel flow-cell is attached and directly changeable with electrode. In the new flow-cell the injection is done through an "in-line luer injection port" which can be less aggressive than wall-jet flow cell for a biological recognition element immobilized on the surface of the electrode. The sample volume can be easily controlled by the operator through a syringe. In this novel thin layer flow-cell screen-printed electrodes, the working electrode was modified with graphene materials, and an enhancement of electroactive area to 388% over a standard electrode was found...
August 21, 2016: Biosensors & Bioelectronics
Gabriela Maria Wiedemann, Max Martin Ludwig Knott, Viola Katharina Vetter, Moritz Rapp, Sascha Haubner, Julia Fesseler, Benjamin Kühnemuth, Patrick Layritz, Raffael Thaler, Stephan Kruger, Steffen Ormanns, Doris Mayr, Stefan Endres, David Anz
In cancer patients, immunosuppression through regulatory T cells (Treg) is a crucial component of tumor immune evasion and contributes to disease progression. Tumor-infiltrating Treg in particular suppress local effector T cell responses and are associated with poor prognosis in tumors such as human pancreatic cancer or hepatocellular carcinoma (HCC). The chemokine CCL22 is known to recruit Treg into the tumor tissue and many types of human tumors are known to express high levels of CCL22. The mechanisms leading to intratumoral secretion of CCL22 are so far unknown...
2016: Oncoimmunology
Vivek Subbiah, Kenneth R Hess, Muhammad Rizwan Khawaja, Michael J Wagner, Chad Tang, Aung Naing, Siqing Fu, Filip Janku, Sarina Piha-Paul, Apostolia M Tsimberidou, Cynthia E Herzog, Joseph A Ludwig, Shreyaskumar Patel, Vinod Ravi, Robert S Benjamin, Funda Meric-Bernstam, David S Hong
Prognosis of patients with advanced sarcoma after progression from FDA approved therapies remains grim. In this study, clinical outcomes of 100 patients with advanced sarcoma who received treatment on novel targeted therapy trials were evaluated. Outcomes of interest included best response, clinical benefit rate, progression-free survival (PFS) and overall survival (OS). Median patient age was 48 years (range 14-80). Patients had received a median of 2 prior lines of systemic treatment. Phase I treatments were anti-VEGF-based (n = 45), mTOR inhibitor-based (n = 15), and anti-VEGF + mTOR inhibitor-based (n = 17) or involved other targets (n = 23)...
October 17, 2016: Scientific Reports
David Ludwig
Current controversies about knowledge integration reflect conflicting ideas of what it means to "take Indigenous knowledge seriously". While there is increased interest in integrating Indigenous and Western scientific knowledge in various disciplines such as anthropology and ethnobiology, integration projects are often accused of recognizing Indigenous knowledge only insofar as it is useful for Western scientists. The aim of this article is to use tools from philosophy of science to develop a model of both successful integration and integration failures...
October 2016: Studies in History and Philosophy of Science
David S Ludwig
No abstract text is available yet for this article.
September 28, 2016: JAMA: the Journal of the American Medical Association
A Keith Stewart, Meletios A Dimopoulos, Tamás Masszi, Ivan Špička, Albert Oriol, Roman Hájek, Laura Rosiñol, David S Siegel, Ruben Niesvizky, Andrzej J Jakubowiak, Jesus F San-Miguel, Heinz Ludwig, Jacqui Buchanan, Kim Cocks, Xinqun Yang, Biao Xing, Naseem Zojwalla, Margaret Tonda, Philippe Moreau, Antonio Palumbo
PURPOSE: To determine the effects of carfilzomib, lenalidomide, and dexamethasone (KRd) versus lenalidomide and dexamethasone (Rd) on health-related quality of life (HR-QoL) in the Carfilzomib, Lenalidomide, and Dexamethasone Versus Lenalidomide and Dexamethasone for the Treatment of Patients With Relapsed Multiple Myeloma (ASPIRE) trial. METHODS: Patients with relapsed multiple myeloma were randomly assigned to receive KRd or Rd. The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 and myeloma-specific module were administered at baseline; day 1 of cycles 3, 6, 12, and 18; and after treatment...
September 6, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
David Gampe, Grigory Nikulin, Ralf Ludwig
Climate change will likely increase pressure on the water balances of Mediterranean basins due to decreasing precipitation and rising temperatures. To overcome the issue of data scarcity the hydrological relevant variables total runoff, surface evaporation, precipitation and air temperature are taken from climate model simulations. The ensemble applied in this study consists of 22 simulations, derived from different combinations of four General Circulation Models (GCMs) forcing different Regional Climate Models (RCMs) and two Representative Concentration Pathways (RCPs) at ~12km horizontal resolution provided through the EURO-CORDEX initiative...
August 15, 2016: Science of the Total Environment
J Andrew Livingston, Kenneth R Hess, Aung Naing, David S Hong, Shreyaskumar Patel, Robert S Benjamin, Joseph A Ludwig, Anthony Conley, Cynthia E Herzog, Pete Anderson, Funda Meric-Bernstam, Razelle Kurzrock, Vivek Subbiah
BACKGROUND: We sought to validate the Royal Marsden Hospital (RMH) and MD Anderson Cancer Center (MDACC) prognostic scoring systems for the selection of bone sarcoma patients for phase I clinical trials and to identify additional risk factors related to survival. PATIENTS AND METHODS: We retrospectively reviewed the baseline characteristics and outcomes of 92 bone sarcoma patients who were referred to MDACC's Phase I Clinical Trials Program. RESULTS: Ninety-two patients with Ewing sarcoma (N = 47), osteosarcoma (N = 22), chondrosarcoma (N = 16), and other tumors (N = 7) were evaluated; 78 were enrolled in at least 1 of 43 different phase I trials...
July 28, 2016: Oncotarget
R Hájek, T Masszi, M T Petrucci, A Palumbo, L Rosiñol, A Nagler, K L Yong, A Oriol, J Minarik, L Pour, M A Dimopoulos, V Maisnar, D Rossi, H Kasparu, J Van Droogenbroeck, D B Yehuda, I Hardan, M Jenner, M Calbecka, M Dávid, J de la Rubia, J Drach, Z Gasztonyi, S Górnik, X Leleu, M Munder, M Offidani, N Zojer, K Rajangam, Y-L Chang, J F San-Miguel, H Ludwig
This randomized, phase III, open-label, multicenter study compared carfilzomib monotherapy against low-dose corticosteroids and optional cyclophosphamide in relapsed and refractory multiple myeloma (RRMM). Relapsed and refractory multiple myeloma patients were randomized (1:1) to receive carfilzomib (10-min intravenous infusion; 20 mg/m(2) on days 1 and 2 of cycle 1; 27 mg/m(2) thereafter) or a control regimen of low-dose corticosteroids (84 mg of dexamethasone or equivalent corticosteroid) with optional cyclophosphamide (1400 mg) for 28-day cycles...
July 15, 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Julia Browne, David L Penn, Claudio L Battaglini, Kelsey Ludwig
The health benefits of exercise are well documented, yet annual health care costs related to physical inactivity are well within the billions. Furthermore, individuals with schizophrenia spectrum disorders (SSDs) are more likely to lead sedentary lives, exercise less than the general population, and die prematurely from preventable causes. Previous research examining the effects of exercise on individuals with SSDs has been encouraging yet limited in creating accessible and sustainable interventions. The current pilot study developed and evaluated the impact of Work out by Walking (WOW), a multicomponent group walking intervention on the health of 16 individuals with SSDs...
September 2016: Journal of Nervous and Mental Disease
Ludwig Kappos, David K B Li, Olaf Stüve, Hans-Peter Hartung, Mark S Freedman, Bernhard Hemmer, Peter Rieckmann, Xavier Montalban, Tjalf Ziemssen, Brian Hunter, Sophie Arnould, Erik Wallström, Krzysztof Selmaj
IMPORTANCE: This dose-blinded extension of the phase 2 BOLD (BAF312 on MRI Lesion Given Once Daily) Study in relapsing-remitting multiple sclerosis provides evidence on disease activity and safety of a range of siponimod doses for up to 24 months. OBJECTIVE: To assess the safety and efficacy of siponimod for up to 24 months during the dose-blinded extension of the BOLD Study. DESIGN, SETTING, AND PARTICIPANTS: At extension baseline in a randomized clinical trial, patients taking siponimod continued at the originally assigned dose and patients taking placebo were rerandomized to the 5 siponimod doses...
September 1, 2016: JAMA Neurology
Alexandra M Mowday, Christopher P Guise, David F Ackerley, Nigel P Minton, Philippe Lambin, Ludwig J Dubois, Jan Theys, Jeff B Smaill, Adam V Patterson
Most solid cancers contain regions of necrotic tissue. The extent of necrosis is associated with poor survival, most likely because it reflects aggressive tumour outgrowth and inflammation. Intravenously injected spores of anaerobic bacteria from the genus Clostridium infiltrate and selectively germinate in these necrotic regions, providing cancer-specific colonisation. The specificity of this system was first demonstrated over 60 years ago and evidence of colonisation has been confirmed in multiple tumour models...
2016: Cancers
Fabian Ludwig Westermann, Vaughn Antony Bell, David Maxwell Suckling, Philip John Lester
Ant species like Pheidole megacephala (F.), Solenopsis invicta (Buren), and the Argentine ant, Linepithema humile (Mayr), have repeatedly been reported to be strongly associated with honeydew-producing arthropods like aphids, scale insects, and mealybugs, effectively protecting them from biological control agents like parasitoids. Here we report the results of a successful trial using pheromone dispensers to suppress Argentine ant activity over large sections in a commercial vineyard over a period of two months and preventing ant access into and foraging within the vine canopy...
August 2016: Journal of Economic Entomology
Pirus Ghadjar, Christoph Pöttgen, Daniela Joos, Stefanie Hayoz, Michael Baumann, Stephan Bodis, Wilfried Budach, Gabriela Studer, Carmen Stromberger, Frank Zimmermann, David Kaul, Ludwig Plasswilm, Heidi Olze, Jacques Bernier, Peter Wust, Daniel M Aebersold, Volker Budach
BACKGROUND: To determine the influence of baseline laboratory values on treatment outcome in patients with locally advanced head and neck cancer (HNSCC). METHODS: Data of the randomized trials ARO 95 -06 (n = 384) and SAKK 10 /94 (n = 224) were pooled for a total sample size of 608 patients. Haemoglobin (Hb) and creatinine (Cr) were available at baseline and their association with locoregional recurrence-free survival (LRRFS), distant metastasis-free survival (DMFS), cancer-specific survival (CSS), and overall survival (OS) was analyzed using univariable and multivariable Cox regression models...
August 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
Marianne Simon, Purificación López-García, Philippe Deschamps, Gwendal Restoux, Paola Bertolino, David Moreira, Ludwig Jardillier
Small and shallow aquatic ecosystems such as ponds and streams constitute a significant proportion of continental surface waters, especially in temperate zones. In comparison with bigger lakes and rivers, they harbor higher biodiversity but they also exhibit reduced buffering capacity face to environmental shifts, such that climate global change can affect them in a more drastic way. For instance, many temperate areas are predicted to undergo droughts with increasing frequency in the near future, which may lead to the temporal desiccation of streams and ponds...
2016: Frontiers in Microbiology
James Ritchie, Darren Green, Tina Chrysochou, Janet Hegarty, Kelly Handley, Natalie Ives, Keith Wheatley, Graeme Houston, Julian Wright, Ludwig Neyses, Nicholas Chalmers, Patrick Mark, Rajan Patel, Jon Moss, Giles Roditi, David Eadington, Elena Lukaschuk, John Cleland, Philip A Kalra
BACKGROUND: Cardiac abnormalities are frequent in patients with atherosclerotic renovascular disease (ARVD). The Angioplasty and Stenting for Renal Artery Lesions (ASTRAL) trial studied the effect of percutaneous renal revascularization combined with medical therapy compared with medical therapy alone in 806 patients with ARVD. METHODS: This was a pre-specified sub-study of ASTRAL (clinical trials registration, current controlled trials number: ISRCTN59586944), designed to consider the effect of percutaneous renal artery angioplasty and stenting on change in cardiac structure and function, measured using cardiac magnetic resonance (CMR) imaging...
June 2, 2016: Nephrology, Dialysis, Transplantation
Ralf Gold, Douglas L Arnold, Amit Bar-Or, Michael Hutchinson, Ludwig Kappos, Eva Havrdova, David G MacManus, Tarek A Yousry, Carlo Pozzilli, Krysztof Selmaj, Marianne T Sweetser, Ray Zhang, Minhua Yang, James Potts, Mark Novas, David H Miller, Nuwan C Kurukulasuriya, Robert J Fox, Theodore J Phillips
BACKGROUND: Delayed-release dimethyl fumarate (DMF) demonstrated strong efficacy and a favorable benefit-risk profile for patients with relapsing-remitting multiple sclerosis (RRMS) in phase 3 DEFINE/CONFIRM studies. ENDORSE is an ongoing long-term extension of DEFINE/CONFIRM. OBJECTIVE: We report efficacy and safety results of a 5-year interim analysis of ENDORSE (2 years DEFINE/CONFIRM; minimum 3 years ENDORSE). METHODS: In ENDORSE, patients randomized to DMF 240 mg twice (BID) or thrice daily (TID) in DEFINE/CONFIRM continued this dosage, and those initially randomized to placebo (PBO) or glatiramer acetate (GA) were re-randomized to DMF 240 mg BID or TID...
May 19, 2016: Multiple Sclerosis: Clinical and Laboratory Research
Michele C Hlavsa, Taryn R Gerth, Sarah A Collier, Elizabeth L Dunbar, Gouthami Rao, Gregory Epperson, Becky Bramlett, David F Ludwig, Diana Gomez, Monty M Stansbury, Freeman Miller, Jeffrey Warren, Jim Nichol, Harry Bowman, Bao-An Huynh, Kara M Loewe, Bob Vincent, Amanda L Tarrier, Timothy Shay, Robert Wright, Allison C Brown, Jasen M Kunz, Kathleen E Fullerton, James R Cope, Michael J Beach
PROBLEM/CONDITION: Aquatic facility-associated illness and injury in the United States include disease outbreaks of infectious or chemical etiology, drowning, and pool chemical-associated health events (e.g., respiratory distress or burns). These conditions affect persons of all ages, particularly young children, and can lead to disability or even death. A total of 650 aquatic facility-associated outbreaks have been reported to CDC for 1978-2012. During 1999-2010, drownings resulted in approximately 4,000 deaths each year in the United States...
2016: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
Cassie A Ludwig, Somasheila I Murthy, Rajeev R Pappuru, Alexandre Jais, David J Myung, Robert T Chang
AIM OF STUDY: To evaluate the ability of ancillary health staff to use a novel smartphone imaging adapter system (EyeGo, now known as Paxos Scope) to capture images of sufficient quality to exclude emergent eye findings. Secondary aims were to assess user and patient experiences during image acquisition, interuser reproducibility, and subjective image quality. MATERIALS AND METHODS: The system captures images using a macro lens and an indirect ophthalmoscopy lens coupled with an iPhone 5S...
March 2016: Indian Journal of Ophthalmology
James F Markmann, Stephen T Bartlett, Paul Johnson, Olle Korsgren, Bernhard J Hering, David Scharp, Thomas W H Kay, Jonathan Bromberg, Jon S Odorico, Gordon C Weir, Nancy Bridges, Raja Kandaswamy, Peter Stock, Peter Friend, Mitsukazu Gotoh, David K C Cooper, Chung-Gyu Park, Philip J OʼConnell, Cherie Stabler, Shinichi Matsumoto, Barbara Ludwig, Pratik Choudhary, Boris Khovatchev, Michael R Rickels, Megan Sykes, Kathryn Wood, Kristy Kraemer, Albert Hwa, Edward Stanley, Camillo Ricordi, Mark Zimmerman, Julia Greenstein, Eduard Montanya, Timo Otonkoski
The International Pancreas and Islet Transplant Association (IPITA), in conjunction with the Transplantation Society (TTS), convened a workshop to consider the future of pancreas and islet transplantation in the context of potential competing technologies that are under development, including the artificial pancreas, transplantation tolerance, xenotransplantation, encapsulation, stem cell derived beta cells, beta cell proliferation, and endogenous regeneration. Separate workgroups for each topic and then the collective group reviewed the state of the art, hurdles to application, and proposed research agenda for each therapy that would allow widespread application...
July 2016: Transplantation
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