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david ludwig

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https://www.readbyqxmd.com/read/29472442/ancient-genomes-revisit-the-ancestry-of-domestic-and-przewalski-s-horses
#1
Charleen Gaunitz, Antoine Fages, Kristian Hanghøj, Anders Albrechtsen, Naveed Khan, Mikkel Schubert, Andaine Seguin-Orlando, Ivy J Owens, Sabine Felkel, Olivier Bignon-Lau, Peter de Barros Damgaard, Alissa Mittnik, Azadeh F Mohaseb, Hossein Davoudi, Saleh Alquraishi, Ahmed H Alfarhan, Khaled A S Al-Rasheid, Eric Crubézy, Norbert Benecke, Sandra Olsen, Dorcas Brown, David Anthony, Ken Massy, Vladimir Pitulko, Aleksei Kasparov, Gottfried Brem, Michael Hofreiter, Gulmira Mukhtarova, Nurbol Baimukhanov, Lembi Lõugas, Vedat Onar, Philipp W Stockhammer, Johannes Krause, Bazartseren Boldgiv, Sainbileg Undrakhbold, Diimaajav Erdenebaatar, Sébastien Lepetz, Marjan Mashkour, Arne Ludwig, Barbara Wallner, Victor Merz, Ilja Merz, Viktor Zaibert, Eske Willerslev, Pablo Librado, Alan K Outram, Ludovic Orlando
The Eneolithic Botai culture of the Central Asian steppes provides the earliest archaeological evidence for horse husbandry, ~5,500 ya, but the exact nature of early horse domestication remains controversial. We generated 42 ancient horse genomes, including 20 from Botai. Compared to 46 published ancient and modern horse genomes, our data indicate that Przewalski's horses are the feral descendants of horses herded at Botai and not truly wild horses. All domestic horses dated from ~4,000 ya to present only show ~2...
February 22, 2018: Science
https://www.readbyqxmd.com/read/29428885/occurrence-of-staphylococcus-aureus-in-swine-and-swine-workplace-environments-on-industrial-and-antibiotic-free-hog-operations-in-north-carolina-usa-a-one-health-pilot-study
#2
Meghan F Davis, Nora Pisanic, Sarah M Rhodes, Alexis Brown, Haley Keller, Maya Nadimpalli, Andrea Christ, Shanna Ludwig, Carly Ordak, Kristoffer Spicer, David C Love, Jesper Larsen, Asher Wright, Sarah Blacklin, Billy Flowers, Jill Stewart, Kenneth G Sexton, Ana M Rule, Christopher D Heaney
Occupational exposure to swine has been associated with increased Staphylococcus aureus carriage, including antimicrobial-resistant strains, and increased risk of infections. To characterize animal and environmental routes of worker exposure, we optimized methods to identify S. aureus on operations that raise swine in confinement with antibiotics (industrial hog operation: IHO) versus on pasture without antibiotics (antibiotic-free hog operation: AFHO). We associated findings from tested swine and environmental samples with those from personal inhalable air samplers on worker surrogates at one IHO and three AFHOs in North Carolina using a new One Health approach...
February 8, 2018: Environmental Research
https://www.readbyqxmd.com/read/29389342/should-dental-care-make-a-transition
#3
EDITORIAL
David C Ludwig, Shane D Morrison
No abstract text is available yet for this article.
February 2018: Journal of the American Dental Association
https://www.readbyqxmd.com/read/29382827/probability-of-phenotypically-detectable-protein-damage-by-enu-induced-mutations-in-the-mutagenetix-database
#4
Tao Wang, Chun Hui Bu, Sara Hildebrand, Gaoxiang Jia, Owen M Siggs, Stephen Lyon, David Pratt, Lindsay Scott, Jamie Russell, Sara Ludwig, Anne R Murray, Eva Marie Y Moresco, Bruce Beutler
Computational inference of mutation effects is necessary for genetic studies in which many mutations must be considered as etiologic candidates. Programs such as PolyPhen-2 predict the relative severity of damage caused by missense mutations, but not the actual probability that a mutation will reduce/eliminate protein function. Based on genotype and phenotype data for 116,330 ENU-induced mutations in the Mutagenetix database, we calculate that putative null mutations, and PolyPhen-2-classified "probably damaging", "possibly damaging", or "probably benign" mutations have, respectively, 61%, 17%, 9...
January 30, 2018: Nature Communications
https://www.readbyqxmd.com/read/29377580/bringing-european-physiologists-together
#5
EDITORIAL
Peter Bie, Ralf Brandes, Susan Deuchars, David Eisner, Joachim Fandrey, Markus Hecker, William Louch, Tomi Taira, Bayram Yilmaz
The modern science of physiology began in Europe. Deciding on exactly who the first physiologist was is not easy but excellent candidates include Claude Bernard and Carl Ludwig. The Nobel Prize in Physiology or Medicine was inaugurated in 1901 with the first award mentioning the word "physiology" being made to Ivan Pavlov (Russia) in 1904. This article is protected by copyright. All rights reserved.
January 29, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29360462/association-between-portosystemic-shunts-and-increased-complications-and-mortality-in-patients-with-cirrhosis
#6
Macarena Simón-Talero, Davide Roccarina, Javier Martínez, Katharina Lampichler, Anna Baiges, Gavin Low, Elba Llop, Michael Praktiknjo, Martin H Maurer, Alexander Zipprich, Michela Triolo, Guillaume Vangrinsven, Rita Garcia-Martinez, Annette Dam, Avik Majumdar, Carmen Picón, Daniel Toth, Anna Darnell, Juan G Abraldes, Marta Lopez, Guido Kukuk, Aleksander Krag, Rafael Bañares, Wim Laleman, Vincenzo La Mura, Cristina Ripoll, Annalisa Berzigotti, Jonel Trebicka, Jose Luis Calleja, Puneeta Tandon, Virginia Hernandez-Gea, Thomas Reiberger, Agustín Albillos, Emmanuel A Tsochatzis, Salvador Augustin, Joan Genescà, Sergi Quiroga, Dominic Yu, Mattias Mandorfer, Juan Carlos Garcia-Pagan, Claudia Berbel, Jose Ferrusquia, Michel Ble, Mari Angeles Garcia-Criado, Ernest Belmonte, Michael Ney, Cristina Margini, Stefania Casu, Giuseppe Murgia, Christiane Ludwig, Martin Rönsch, Dietrich Stoevesandt, Laura Carrion, Enrique Ramón Botella
BACKGROUND & AIMS: Spontaneous portosystemic shunts (SPSSs) have been associated with hepatic encephalopathy (HE). Little is known about their prevalence among patients with cirrhosis or clinical effects. We investigated the prevalence and characteristics of SPSSs in patients with cirrhosis and their outcomes. METHODS: We performed a retrospective study of 1729 patients with cirrhosis who underwent abdominal computed tomography or magnetic resonance imaging analysis from 2010 through 2015 at 14 centers in Canada and Europe...
January 20, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29353550/ectrims-ean-guideline-on-the-pharmacological-treatment-of-people-with-multiple-sclerosis
#7
Xavier Montalban, Ralf Gold, Alan J Thompson, Susana Otero-Romero, Maria Pia Amato, Dhia Chandraratna, Michel Clanet, Giancarlo Comi, Tobias Derfuss, Franz Fazekas, Hans Peter Hartung, Eva Havrdova, Bernhard Hemmer, Ludwig Kappos, Roland Liblau, Catherine Lubetzki, Elena Marcus, David H Miller, Tomas Olsson, Steve Pilling, Krysztof Selmaj, Axel Siva, Per Soelberg Sorensen, Maria Pia Sormani, Christoph Thalheim, Heinz Wiendl, Frauke Zipp
BACKGROUND: Multiple sclerosis (MS) is a complex disease with new drugs becoming available in the past years. There is a need for a reference tool compiling current data to aid professionals in treatment decisions. OBJECTIVES: To develop an evidence-based clinical practice guideline for the pharmacological treatment of people with MS. METHODS: This guideline has been developed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology and following the updated EAN recommendations...
January 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29341834/improvement-in-overall-survival-with-carfilzomib-lenalidomide-and-dexamethasone-in-patients-with-relapsed-or-refractory-multiple-myeloma
#8
David S Siegel, Meletios A Dimopoulos, Heinz Ludwig, Thierry Facon, Hartmut Goldschmidt, Andrzej Jakubowiak, Jesus San-Miguel, Mihaela Obreja, Julie Blaedel, A Keith Stewart
Purpose In the ASPIRE study of carfilzomib, lenalidomide, and dexamethasone (KRd) versus lenalidomide plus dexamethasone (Rd) in patients with relapsed or refractory multiple myeloma, progression-free survival was significantly improved in the carfilzomib group (hazard ratio, 0.69; two-sided P < .001). This prespecified analysis reports final overall survival (OS) data and updated safety results. Patients and Methods Adults with relapsed multiple myeloma (one to three prior lines of therapy) were eligible and randomly assigned at a one-to-one ratio to receive KRd or Rd in 28-day cycles until withdrawal of consent, disease progression, or occurrence of unacceptable toxicity...
January 17, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29295838/genetic-evidence-that-carbohydrate-stimulated-insulin-secretion-leads-to-obesity
#9
Christina M Astley, Jennifer N Todd, Rany M Salem, Sailaja Vedantam, Cara B Ebbeling, Paul L Huang, David S Ludwig, Joel N Hirschhorn, Jose C Florez
BACKGROUND: A fundamental precept of the carbohydrate-insulin model of obesity is that insulin secretion drives weight gain. However, fasting hyperinsulinemia can also be driven by obesity-induced insulin resistance. We used genetic variation to isolate and estimate the potentially causal effect of insulin secretion on body weight. METHODS: Genetic instruments of variation of insulin secretion [assessed as insulin concentration 30 min after oral glucose (insulin-30)] were used to estimate the causal relationship between increased insulin secretion and body mass index (BMI), using bidirectional Mendelian randomization analysis of genome-wide association studies...
January 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29288894/delivery-of-ru-%C3%AE-6-p-cymene-cl2-ph2p-ch2-3sph-%C3%AE%C2%BAp-using-unfunctionalized-and-mercapto-functionalized-sba-15-mesoporous-silica-preparation-characterization-and-in-vitro-study
#10
David Edeler, Sören Arlt, Vladana Petković, Gerd Ludwig, Dijana Drača, Danijela Maksimović-Ivanić, Sanja Mijatović, Goran N Kaluđerović
SBA-15 (Santa Barbara Amorphous 15) mesoporous silica and its functionalized form (with 3-mercaptopropyltriethoxysilane) SBA-15~SH were used as carriers for [Ru(η6-p-cymene)Cl2{Ph2P(CH2)3SPh-κP}] complex, denoted as [Ru]. Prepared mesoporous silica nanomaterials were characterized by traditional methods. Materials without [Ru] complex did not show any cytotoxic activity against melanoma B16 and B16-F10 cell lines. On the contrary, materials containing [Ru] such as SBA-15|[Ru] and SBA-15~SH|[Ru], exhibited very high activity against tested tumor cell lines, moreover with similar inhibitory potential...
December 22, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29288172/effectiveness-and-cost-effectiveness-of-a-guided-internet-and-mobile-based-depression-intervention-for-individuals-with-chronic-back-pain-protocol-of-a-multi-centre-randomised-controlled-trial
#11
Jiaxi Lin, Lasse Sander, Sarah Paganini, Sandra Schlicker, David Ebert, Matthias Berking, Jürgen Bengel, Stephanie Nobis, Dirk Lehr, Oskar Mittag, Heleen Riper, Harald Baumeister
INTRODUCTION: Depression often co-occurs with chronic back pain (CBP). Internet and mobile-based interventions (IMIs) might be a promising approach for effectively treating depression in this patient group. In the present study, we will evaluate the effectiveness and cost-effectiveness of a guided depression IMI for individuals with CBP (eSano BackCare-D) integrated into orthopaedic healthcare. METHODS AND ANALYSIS: In this multicentre randomised controlled trial of parallel design, the groups eSano BackCare-D versus treatment as usual will be compared...
December 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/29282826/rational-design-binding-studies-and-crystal-structure-evaluation-of-the-first-ligand-targeting-the-dimerization-interface-of-the-14-3-3%C3%AE-adapter-protein
#12
Carsten Schmuck, Martin Ehlers, Jean-Noel Grad, Sumit Mittal, David Bier, Marcel Mertel, Ludwig Ohl, Maria Bartel, Jeroen Briels, Marius Heimann, Christian Ottmann, Elsa Sanchez-Garcia, Daniel Hoffmann
14-3-3 proteins play a central role in signaling pathways in cells: they interact as gatekeeper proteins with a huge number of binding partners. Their function as hub for intracellular communication can explain why these adapter proteins are associated with a wide range of diseases. How they control the various cellular mechanisms is still unclear, but it is assumed that the dimeric nature of the 14-3-3 proteins plays a key role in their activity. Here we present, to the best of our knowledge, the first example of a small molecule binding to the 14-3-3ζ dimerization interface...
December 28, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29275977/diagnosis-of-multiple-sclerosis-2017-revisions-of-the-mcdonald-criteria
#13
REVIEW
Alan J Thompson, Brenda L Banwell, Frederik Barkhof, William M Carroll, Timothy Coetzee, Giancarlo Comi, Jorge Correale, Franz Fazekas, Massimo Filippi, Mark S Freedman, Kazuo Fujihara, Steven L Galetta, Hans Peter Hartung, Ludwig Kappos, Fred D Lublin, Ruth Ann Marrie, Aaron E Miller, David H Miller, Xavier Montalban, Ellen M Mowry, Per Soelberg Sorensen, Mar Tintoré, Anthony L Traboulsee, Maria Trojano, Bernard M J Uitdehaag, Sandra Vukusic, Emmanuelle Waubant, Brian G Weinshenker, Stephen C Reingold, Jeffrey A Cohen
The 2010 McDonald criteria for the diagnosis of multiple sclerosis are widely used in research and clinical practice. Scientific advances in the past 7 years suggest that they might no longer provide the most up-to-date guidance for clinicians and researchers. The International Panel on Diagnosis of Multiple Sclerosis reviewed the 2010 McDonald criteria and recommended revisions. The 2017 McDonald criteria continue to apply primarily to patients experiencing a typical clinically isolated syndrome, define what is needed to fulfil dissemination in time and space of lesions in the CNS, and stress the need for no better explanation for the presentation...
December 21, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/29275859/microbiome-influences-prenatal-and-adult-microglia-in-a-sex-specific-manner
#14
Morgane Sonia Thion, Donovan Low, Aymeric Silvin, Jinmiao Chen, Pauline Grisel, Jonas Schulte-Schrepping, Ronnie Blecher, Thomas Ulas, Paola Squarzoni, Guillaume Hoeffel, Fanny Coulpier, Eleni Siopi, Friederike Sophie David, Claus Scholz, Foo Shihui, Josephine Lum, Arlaine Anne Amoyo, Anis Larbi, Michael Poidinger, Anne Buttgereit, Pierre-Marie Lledo, Melanie Greter, Jerry Kok Yen Chan, Ido Amit, Marc Beyer, Joachim Ludwig Schultze, Andreas Schlitzer, Sven Pettersson, Florent Ginhoux, Sonia Garel
Microglia are embryonically seeded macrophages that contribute to brain development, homeostasis, and pathologies. It is thus essential to decipher how microglial properties are temporally regulated by intrinsic and extrinsic factors, such as sexual identity and the microbiome. Here, we found that microglia undergo differentiation phases, discernable by transcriptomic signatures and chromatin accessibility landscapes, which can diverge in adult males and females. Remarkably, the absence of microbiome in germ-free mice had a time and sexually dimorphic impact both prenatally and postnatally: microglia were more profoundly perturbed in male embryos and female adults...
December 21, 2017: Cell
https://www.readbyqxmd.com/read/29241016/reply-to-increased-propensity-for-pneumonia-with-fluticasone-in-copd
#15
David A Lipson, Helen Barnacle, Ruby Birk, Noushin Brealey, Nicholas Locantore, David A Lomas, Andrea Ludwig-Sengpiel, Rajat Mohindra, Maggie Tabberer, Chang-Qing Zhu, Steven J Pascoe
No abstract text is available yet for this article.
December 14, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29233719/a-randomized-study-of-dietary-composition-during-weight-loss-maintenance-rationale-study-design-intervention-and-assessment
#16
Cara B Ebbeling, Gloria L Klein, Patricia K Luoto, Julia M W Wong, Lisa Bielak, Ralph G Eddy, Sarah K Steltz, Courtenay Devlin, Megan Sandman, Bridget Hron, Kim Shimy, Steven B Heymsfield, Robert R Wolfe, William W Wong, Henry A Feldman, David S Ludwig
BACKGROUND: While many people with overweight or obesity can lose weight temporarily, most have difficulty maintaining weight loss over the long term. Studies of dietary composition typically focus on weight loss, rather than weight-loss maintenance, and rely on nutrition education and dietary counseling, rather than controlled feeding protocols. Variation in initial weight loss and insufficient differentiation among treatments confound interpretation of results and compromise conclusions regarding the weight-independent effects of dietary composition...
December 9, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29198827/systematic-three-dimensional-coculture-rapidly-recapitulates-interactions-between-human-neurons-and-astrocytes
#17
Robert Krencik, Kyounghee Seo, Jessy V van Asperen, Nupur Basu, Caroline Cvetkovic, Saba Barlas, Robert Chen, Connor Ludwig, Chao Wang, Michael E Ward, Li Gan, Philip J Horner, David H Rowitch, Erik M Ullian
Human astrocytes network with neurons in dynamic ways that are still poorly defined. Our ability to model this relationship is hampered by the lack of relevant and convenient tools to recapitulate this complex interaction. To address this barrier, we have devised efficient coculture systems utilizing 3D organoid-like spheres, termed asteroids, containing pre-differentiated human pluripotent stem cell (hPSC)-derived astrocytes (hAstros) combined with neurons generated from hPSC-derived neural stem cells (hNeurons) or directly induced via Neurogenin 2 overexpression (iNeurons)...
November 27, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/29178263/characterizing-the-free-volume-of-ultrahigh-molecular-weight-polyethylene-to-predict-diffusion-coefficients-in-orthopedic-liners
#18
Kyle B Ludwig, Vaishnavi Chandrasekar, David M Saylor, Douglas W Van Citters, Steven D Reinitz, Christopher Forrey, Martin K McDermott, Samanthi Wickramasekara, Dustin W Janes
Liners used in orthopedic devices are often made from ultrahigh molecular weight polyethylene (UHMWPE). A general predictive capability for transport coefficients of small molecules in UHMWPE does not exist, making it difficult to assess properties associated with leaching or uptake of small molecules. To address this gap, we describe here how a form of the Vrentas-Duda free volume model can be used to predict upper-bound diffusion coefficients (D) of arbitrary molecules within UHMWPE on the basis of their size and shape...
November 27, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29138631/sarc006-phase-ii-trial-of-chemotherapy-in-sporadic-and-neurofibromatosis-type-1-associated-chemotherapy-naive-malignant-peripheral-nerve-sheath-tumors
#19
Christine S Higham, Seth M Steinberg, Eva Dombi, Arie Perry, Lee J Helman, Scott M Schuetze, Joseph A Ludwig, Arthur Staddon, Mohammed M Milhem, Daniel Rushing, Robin L Jones, Michael Livingston, Stewart Goldman, Christopher Moertel, Lars Wagner, David Janhofer, Christina M Annunziata, Denise Reinke, Lauren Long, David Viskochil, Larry Baker, Brigitte C Widemann
Background: Worse chemotherapy response for neurofibromatosis type 1- (NF1-) associated compared to sporadic malignant peripheral nerve sheath tumors (MPNST) has been reported. Methods: We evaluated the objective response (OR) rate of patients with AJCC Stage III/IV chemotherapy-naive NF1 MPNST versus sporadic MPNST after 4 cycles of neoadjuvant chemotherapy, 2 cycles of ifosfamide/doxorubicin, and 2 cycles of ifosfamide/etoposide. A Simon optimal two-stage design was used (target response rate 40%)...
2017: Sarcoma
https://www.readbyqxmd.com/read/29118063/dietary-fat-friend-or-foe
#20
Cara B Ebbeling, Ian S Young, Alice H Lichtenstein, David S Ludwig, Michelle McKinley, Rafael Perez-Escamilla, Eric Rimm
No abstract text is available yet for this article.
November 8, 2017: Clinical Chemistry
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