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https://www.readbyqxmd.com/read/28212466/withdrawn-propranolol-for-migraine-prophylaxis
#1
REVIEW
Klaus Linde, Karin Rossnagel
BACKGROUND: Propranolol is one of the most commonly prescribed drugs for migraine prophylaxis. OBJECTIVES: We aimed to determine whether there is evidence that propranolol is more effective than placebo and as effective as other drugs for the interval (prophylactic) treatment of patients with migraine. SEARCH METHODS: Potentially eligible studies were identified by searching MEDLINE/PubMed (1966 to May 2003) and the Cochrane Central Register of Controlled Trials (Issue 2, 2003), and by screening bibliographies of reviews and identified articles...
February 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28208907/current-practice-of-hypertension-in-india-focus-on-blood-pressure-goals
#2
Jagdish S Hiremath, Vijay M Katekhaye, Vijay S Chamle, Rishi M Jain, Amit I Bhargava
INTRODUCTION: Recommended Blood Pressure (BP) goals in elderly and those with co-morbid conditions like Diabetes Mellitus (DM) and Chronic Kidney Disease (CKD) vary in different Hypertension (HTN) management guidelines. AIM: To understand currently followed BP goals and practices among the physicians involved in management of HTN in India. MATERIALS AND METHODS: A cross-sectional, observational survey was conducted at 66(th) annual conference of Cardiological Society of India (CSICON-2014, Hyderabad)...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28203288/nebivolol-versus-other-beta-blockers-in-patients-with-hypertension-and-erectile-dysfunction
#3
REVIEW
Randall P Sharp, Barry J Gales
Erectile dysfunction (ED) impacts over 100 million men worldwide and occurs at a higher incidence in men with hypertension. Beta blockers are one of several antihypertensive drug classes associated with ED. Nebivolol is a beta blocker with vasodilating properties mediated through endothelial release of nitric oxide which facilitates penile erection. Thus, nebivolol may offer an advantage over other beta blockers in the patient with hypertension and ED. A literature search comparing nebivolol with other beta blockers identified four European studies of limited duration, with the longest study being 28 weeks...
February 2017: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/28196319/common-skin-conditions-in-children-congenital-melanocytic-nevi-and-infantile-hemangiomas
#4
Brian Z Rayala, Dean S Morrell
Congenital melanocytic nevi (CMN) are hamartomas present at birth that are composed of nevomelanocytes and thought to originate from faulty migration of precursor melanocytes in the neural crest. Classification is based on projected adult size of the lesion. CMN size correlates positively with risk of melanoma and neurocutaneous melanocytosis. Management requires a patient-centered approach that weighs the risks and benefits of and alternatives to complete removal. All children with large and giant CMN, regardless of surgical status, should be monitored closely and undergo periodic skin examination...
February 2017: FP Essentials
https://www.readbyqxmd.com/read/28195341/left-ventricular-systolic-function-is-associated-to-sympathetic-nervous-activity-and-markers-of-inflammation-in-cirrhosis
#5
Raquel Yotti, Cristina Ripoll, Yolanda Benito, Maria Vega Catalina, Jaime Elízaga, Diego Rincón, Francisco Fernández-Avilés, Javier Bermejo, Rafael Bañares
: An accurate evaluation of cardiac function in patients with cirrhosis remains a challenge. We used robust echocardiographic indices to characterize LV systolic function and its relationship to activation of the sympathetic nervous system (SNS) and inflammation in 59 patients cirrhosis and 59 age-matched controls. Aditionally, in eleven patients we withdrew betablockers and diuretics and used phenylephrine and albumin infusion to evaluate the response to acute afterload and preload changes (interventional substudy)...
February 13, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28188000/effectiveness-of-a-management-program-for-outpatient-clinic-or-remote-titration-of-beta-blockers-in-crt-patients-the-restore-study
#6
Antonio D'Onofrio, Pietro Palmisano, Antonio Rapacciuolo, Ernesto Ammendola, Leonardo Calò, Antonio Ruocco, Valter Bianchi, Fabio Maresca, Giuseppe Del Giorno, Annamaria Martino, Ciro Mauro, Monica Campari, Sergio Valsecchi, Michele Accogli
BACKGROUND: Many patients fail to receive β-blockers before cardiac resynchronization therapy defibrillator (CRT-D) implantation, or receive them at a suboptimal dose, and require optimization after implantation. We assessed the effectiveness of a structured program for β-blocker titration in CRT-D patients followed up by means of conventional in-clinic visits or remote monitoring. METHODS AND RESULTS: 130 patients undergoing CRT implantation and treated according to the standard practice of the centers were included as a control group...
February 5, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28187503/beneficial-and-harmful-effects-of-non-selective-beta-blockade-on-acute-kidney-injury-in-liver-transplant-candidates
#7
Sang Gyune Kim, Joseph J Larson, Ji Sung Lee, Therneau M Terry, W Ray Kim
Non-selective beta-blockers have played an important role in the prevention of portal hypertensive bleeding in cirrhotic patients. However, recent studies have suggested that non-selective beta-blockers may be harmful in some patients with end-stage liver disease. To evaluate the association between use of non-selective beta-blocker and the incidence of acute kidney injury (AKI). We conducted a nested case-control study in a cohort of liver transplant waitlist registrants. Each patient with AKI was matched to a control by the model for end-stage liver disease (MELD)-Na score, age, serum creatinine, and follow-up duration...
February 10, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28186869/sedative-hypnotic-drug-withdrawal-syndrome-recognition-and-treatment
#8
Cynthia Santos, Ruben E Olmedo
Sedative-hypnotic drugs include gamma-Aminobutyric acid (GABA)ergic agents such as benzodiazepines, barbiturates, gamma-Hydroxybutyric acid [GHB], gamma-Butyrolactone [GBL], baclofen, and ethanol. Chronic use of these substances can cause tolerance, and abrupt cessation or a reduction in the quantity of the drug can precipitate a life-threatening withdrawal syndrome. Benzodiazepines, phenobarbital, propofol, and other GABA agonists or analogues can effectively control symptoms of withdrawal from GABAergic agents...
March 2017: Emergency Medicine Practice
https://www.readbyqxmd.com/read/28185171/neprilysin-inhibitors-in-cardiovascular-disease
#9
REVIEW
Guson Kang, Dipanjan Banerjee
Mortality from heart failure remains high despite advances in medical therapy over the last three decades. Angiotensin receptor-neprilysin inhibitor (ARNI) combinations are the latest addition to the heart failure medical armamentarium, which is built on the cornerstone regimen of beta blockers, angiotensin converting enzyme (ACE) inhibitors/angiotensin receptor blockers, and aldosterone antagonists. Recent trial data have shown a significant mortality benefit from ARNIs, which, as of May 2016, have now received a class I recommendation for use in patients with heart failure and reduced ejection fraction from the major American and European cardiology societies...
February 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28185035/anthracycline-chemotherapy-and-cardiotoxicity
#10
John V McGowan, Robin Chung, Angshuman Maulik, Izabela Piotrowska, J Malcolm Walker, Derek M Yellon
Anthracycline chemotherapy maintains a prominent role in treating many forms of cancer. Cardiotoxic side effects limit their dosing and improved cancer outcomes expose the cancer survivor to increased cardiovascular morbidity and mortality. The basic mechanisms of cardiotoxicity may involve direct pathways for reactive oxygen species generation and topoisomerase 2 as well as other indirect pathways. Cardioprotective treatments are few and those that have been examined include renin angiotensin system blockade, beta blockers, or the iron chelator dexrazoxane...
February 9, 2017: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/28181117/cyp2d6-genetic-variation-and-beta-blocker-maintenance-dose-in-patients-with-heart-failure
#11
Jasmine A Luzum, Kevin M Sweet, Philip F Binkley, Tara J Schmidlen, Joseph P Jarvis, Michael F Christman, Wolfgang Sadee, Joseph P Kitzmiller
PURPOSE: This study examined whether a CYP2D6 polymorphism (CYP2D6*4) was related to beta-blocker maintenance dose in patients with heart failure. METHODS: Logistic regression modeling was utilized in a retrospective chart-review analysis of heart-failure patients (60% Male, 90% of European descent) to assess whether CYP2D6*4 (non-functional CYP2D6 allele present in 1 of 5 individuals of European descent) is associated with maintenance dose of carvedilol (n = 65) or metoprolol (n = 33)...
February 8, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28179398/medical-therapy-for-secondary-prevention-and-long-term-outcome-in-patients-with-myocardial-infarction-with-non-obstructive-coronary-artery-minoca-disease
#12
Bertil Lindahl, Tomasz Baron, David Erlinge, Nermin Hadziosmanovic, Anna M Nordenskjöld, Anton Gard, Tomas Jernberg
Background -Myocardial infarction (MI) with non-obstructive coronary arteries (MINOCA) occurs in 5-10% of all patients with MI. Clinical trials of secondary prevention treatment in MINOCA patients are lacking. Therefore, the aim of this study was to examine the associations between treatment with statins, renin-angiotensin system blockers, beta-blockers, dual antiplatelet therapy and long-term cardiovascular events. Methods -Observational study of MINOCA patients recorded in the SWEDEHEART registry between July 2003 and June 2013 and followed until December 2013 for outcome events in the Swedish Cause of Death Register and National Patient Register...
February 8, 2017: Circulation
https://www.readbyqxmd.com/read/28178210/perindopril-induces-tsp-1-expression-in-hypertensive-patients-with-endothelial-dysfunction-in-chronic-treatment
#13
Valentina Buda, Minodora Andor, Lucian Petrescu, Carmen Cristescu, Dana Emilia Baibata, Mirela Voicu, Melania Munteanu, Ioana Citu, Calin Muntean, Octavian Cretu, Mirela Cleopatra Tomescu
Thrombospondin-1 (TSP-1) is a potent endogenous inhibitor of both physiological and pathological angiogenesis, widely studied as a target in drug development for treating cancer. Several studies performed in the cardiovascular field on TSP-1 are contradictory, the role of TSP-1 in the physiopathology of cardiovascular disorders (CVDs) being, for the moment, incompletely understood and may be due to the presence of several domains in its structure which can stimulate many cellular receptors. It has been reported to inhibit NO-mediated signaling and to act on the angiogenesis, tissue perfusion, endothelial cell proliferation, and homeostasis, so we aimed to quantify the effect Perindopril has on TSP-1 plasma levels in hypertensive patients with endothelial dysfunction in comparison with other antihypertensive drugs, such as beta blockers, calcium channel blockers, and diuretics, in a chronic treatment...
February 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28176581/correction
#14
(no author information available yet)
There was an error in our CPD article Chronic heart failure part 2: treatment and management (11 January). On page 55, the first sentence in the angiotensin receptor neprilysin inhibitor section should read: Valsartan with sacubitril is an angiotensin receptor neprilysin inhibitor that has recently been approved for use as a replacement for ACE inhibitors, to further reduce the risk of hospitalisation and death in ambulatory patients with heart failure and an ejection fraction ≤35% who remain symptomatic despite optimal treatment with an ACE inhibitor, a beta-blocker and an aldersterone antagonist (Ponikowski et al 2016)...
February 8, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28173005/p716-beta-blocker-use-is-associated-with-a-higher-relapse-risk-of-inflammatory-bowel-disease-a-dutch-retrospective-cohort-study
#15
R Willemze, T Bakker, M Pippias, C Ponsioen, W de Jonge
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28167537/site-specific-o-glycosylation-by-polypeptide-galnac-transferase-t2-co-regulates-beta1-adrenergic-receptor-n-terminal-cleavage
#16
Christoffer K Goth, Hanna E Tuhkanen, Hamayun Khan, Jarkko J Lackman, Shengjun Wang, Yoshiki Narimatsu, Lasse Holst Hansen, Christopher Overall, Henrik Clausen, Katrine T Schjoldager, Ulla E Petäjä-Repo
The β1-adrenergic receptor (β1AR) is a G protein-coupled receptor (GPCR) and the predominant adrenergic receptor subtype in the heart, where it mediates cardiac contractility and the force of contraction. Although it is the most important target for β-adrenergic antagonists, such as beta-blockers, relatively little is still known about its regulation. We have previously shown that β1AR undergoes constitutive and regulated N-terminal cleavage participating in receptor down-regulation, and moreover that the receptor is modified by O-glycosylation...
February 6, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28159822/beta-blocker-use-is-associated-with-impaired-left-atrial-function-in-hypertension
#17
Mayank Sardana, Amer Ahmed Syed, Zeba Hashmath, Timothy S Phan, Maheswara R Koppula, Uzma Kewan, Zoubair Ahmed, Ravikantha Chandamuri, Swapna Varakantam, Ejaz Shah, Ryan Gorz, Scott R Akers, Julio A Chirinos
BACKGROUND: Impaired left atrial (LA) mechanical function is present in hypertension and likely contributes to various complications, including atrial arrhythmias, stroke, and heart failure. Various antihypertensive drug classes exert differential effects on central hemodynamics and left ventricular function. However, little is known about their effects on LA function. METHODS AND RESULTS: We studied 212 subjects with hypertension and without heart failure or atrial fibrillation...
February 3, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28153534/the-smoking-habit-influences-negatively-the-autonomic-heart-control-in-community-dwelling-old-adults
#18
Edvar Pereira Nascimento Júnior, Ícaro J S Ribeiro, Ivna Vidal Freire, Rafael da Silva Passos, Cezar Augusto Casotti, Rafael Pereira
OBJECTIVE: The present study aimed to analyze the influence of smoking on the heart autonomic control in old adults with and without smoking habit. METHODS: In a population-based study, all community-dwelling old adults (≥60 years old) from Aiquara, Bahia, Brazil, were invited to participate in the study. Two hundred and thirty-two (232) old adults gave information about smoking habits and were submitted to 5-min recordings of successive RR intervals. The analysis of the RR intervals variability was carried out in time and frequency domains, and with nonlinear methods...
January 30, 2017: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/28132057/is-beta-blocker-use-beneficial-in-breast-cancer-a-meta-analysis
#19
Hyun Yul Kim, Youn Joo Jung, Sang Hyup Lee, Hyuk Jae Jung, Kyoungjune Pak
OBJECTIVE: Preclinical studies have proved that beta-blocking agents inhibit several pathways for breast cancer progression and metastasis. We aimed to evaluate the association between beta-blocker use and prognosis of breast cancer. METHODS: A systematic search for studies from MEDLINE and EMBASE (inception to March 2014) was performed using the keywords "breast cancer" and "beta-blocker." In 2 groups of breast cancer patients (beta-blocker users and non-beta-blocker users), overall deaths (ODs), cancer-specific deaths (CSDs), and recurrences were compared...
January 28, 2017: Oncology
https://www.readbyqxmd.com/read/28130548/allosteric-beta-blocker-isolated-from-a-dna-encoded-small-molecule-library
#20
Seungkirl Ahn, Alem W Kahsai, Biswaranjan Pani, Qin-Ting Wang, Shuai Zhao, Alissa L Wall, Ryan T Strachan, Dean P Staus, Laura M Wingler, Lillian D Sun, Justine Sinnaeve, Minjung Choi, Ted Cho, Thomas T Xu, Gwenn M Hansen, Michael B Burnett, Jane E Lamerdin, Daniel L Bassoni, Bryant J Gavino, Gitte Husemoen, Eva K Olsen, Thomas Franch, Stefano Costanzi, Xin Chen, Robert J Lefkowitz
The β2-adrenergic receptor (β2AR) has been a model system for understanding regulatory mechanisms of G-protein-coupled receptor (GPCR) actions and plays a significant role in cardiovascular and pulmonary diseases. Because all known β-adrenergic receptor drugs target the orthosteric binding site of the receptor, we set out to isolate allosteric ligands for this receptor by panning DNA-encoded small-molecule libraries comprising 190 million distinct compounds against purified human β2AR. Here, we report the discovery of a small-molecule negative allosteric modulator (antagonist), compound 15 [([4-((2S)-3-(((S)-3-(3-bromophenyl)-1-(methylamino)-1-oxopropan-2-yl)amino)-2-(2-cyclohexyl-2-phenylacetamido)-3-oxopropyl)benzamide], exhibiting a unique chemotype and low micromolar affinity for the β2AR...
January 27, 2017: Proceedings of the National Academy of Sciences of the United States of America
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