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https://www.readbyqxmd.com/read/29931205/cowden-syndrome-pituitary-tumours
#1
Panudda Srichomkwun, Natnicha Houngngam, Patchaya Boonchaya-Anant, Aurauma Chutinet, Patinut Buranasupkajorn, Thiti Snabboon
No abstract text is available yet for this article.
June 20, 2018: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29925553/analgesic-effect-of-long-acting-somatostatin-receptor-agonist-pasireotide-in-a-patient-with-acromegaly-and-intractable-headaches
#2
Christina M Lovato, Patricia L Kapsner
A 22-year-old woman presented with worsening vision loss and headaches. A diagnosis of acromegaly was confirmed after detection of an invasive pituitary macroadenoma and biochemical testing. Despite two attempts of surgical debulking of the tumour and administration of long-acting octreotide and cabergoline, growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels were uncontrolled. The patient experienced persistent headaches despite surgery, gamma knife radiation and ventriculoperitoneal shunt placement; she was then enrolled in the ACCESS trial (ClinicalTrials...
June 19, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29920729/long-term-follow-up-of-a-large-prospective-cohort-of-patients-with-non-functioning-pituitary-adenomas-the-outcome-of-a-conservative-management-policy
#3
Miles J Levy, Iain J Robertson, Naima Khalk, Sabrina Vitello, Narendra Reddy, Ragini Bhake, Trevor A Howlett
OBJECTIVE: To assess the clinical outcome of a strategy of conservative monitoring of patients with non-functioning pituitary adenomas (NFPA) after pituitary surgery and in patients without surgery. DESIGN: Retrospective study of outcomes, using a clinical information system. PATIENTS: An unselected, clinical series of patients seen in a single centre between 1989 and 2015. MEASUREMENTS: Review of clinical information system data to obtain details and dates of surgery, radiotherapy, pituitary imaging and outcomes...
June 19, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29895525/the-hypothalamic-pituitary-adrenal-axis-in-childhood-cancer-survivors
#4
Christina Wei, Elizabeth Crowne
Endocrine abnormalities are common among childhood cancer survivors. Abnormalities of the hypothalamic-pituitary-adrenal axis (HPAA) are the least common, but the consequences are severe if missed. Patients with tumours located and /or had surgery performed near the hypothalamic-pituitary region and those treated with an accumulative cranial radiotherapy dose of over 30 Gy are most at risk of adrenocorticotrophic hormone (ACTH) deficiency. Primary adrenal insufficiency may occur in patients with tumours located in or involving one or both adrenals...
June 12, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29895434/-thickening-of-the-pituitary-stalk-in-children-and-adolescents-with-central-diabetes-insipidus-causes-and-consequences
#5
Beatriz Corredor Andrés, María Teresa Muñoz Calvo, Miguel Ángel López Pino, María Márquez Rivera, Lourdes Travieso Suárez, Jesús Pozo Román, Jesús Argente
BACKGROUND: Central diabetes insipidus (CDI) is a rare disorder in children. The aetiology of CDI in childhood is heterogeneous. The aim of this study is to illustrate the importance of a careful clinical and neuro-radiological follow-up of the pituitary and hypothalamus region in order to identify the aetiology and the development of associated hormonal deficiencies. METHODS: Clinical and auxological variables of 15 children diagnosed with CDI were retrospectively analysed in a paediatric hospital...
June 9, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29886642/-clinical-significance-of-european-society-of-endocrinology-clinical-practice-guidelines-for-the-management-of-aggressive-pituitary-tumours-and-carcinomas
#6
X H Liu, R Z Wang, C X Dai
No abstract text is available yet for this article.
May 29, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29870628/a-case-of-secondary-sunct-syndrome
#7
Gunay Gul, Melek Kandemir, Batuhan Kara, Nazan Karagoz Sakalli, Fulya Sengul Eren
SUNCT syndrome, a rare form of primary headaches, may be secondary to pituitary tumours. The secondary forms usually related with prolactinomas. The response of dopamin agonists could be variable. In this study, we reported a case of SUNCT syndrome secondary to prolactinoma. Cranial magnetic resonance imaging was performed for this patient because of the increase in pain severity and frequency. A hemorrhage was detected into the prolactinoma ipsilateral to the pain. The headache attacks were taken undercontrol and remission was ensured with cabergoline in a short time...
September 30, 2017: Ideggyógyászati Szemle
https://www.readbyqxmd.com/read/29858859/localised-langerhans-cell-histiocytosis-of-the-hypothalamic-pituitary-region-case-report-and-literature-review
#8
REVIEW
Danijela Radojkovic, Milica Pesic, Dragan Dimic, Tatjana Radjenovic Petkovic, Sasa Radenkovic, Milena Velojic-Golubovic, Vesna Novak, Ivan Ilic, Milan Radojkovic
INTRODUCTION: Langerhans cell histiocytosis (LCH) localised in the hypothalamic-pituitary region (HPR) is very rare, especially in adults. Diabetes insipidus (DI) is considered to be a hallmark of HPR LCH, while anterior pituitary abnormalities are usually seen as consequences of surgery, radiotherapy or chemotherapy. CASE DESCRIPTION: We present a patient with localised HPR LCH with dominant anterior pituitary dysfunction and tumour mass effects but without DI...
March 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29858852/clinical-and-epidemiological-characteristics-of-pituitary-tumours-in-a-single-centre-in-saudi-arabia
#9
Salma H Hussein, Tayba S Wahedi, Naji Al Johani, Yasser A Hakami, Kamal Alzahrani, Mussa H AlMalki
PURPOSE: Pituitary tumours are slowly progressing tumours, mostly benign, with a reported global prevalence of 16.7% (22.5% in radiologic studies and 14.4% in autopsy studies). Clinical and epidemiological data on pituitary adenomas in Saudi Arabia are lacking. We aimed to utilise our database variables to determine clinical and epidemiological characteristics as well as treatment outcomes of pituitary tumours among Saudi patients. METHODS: This retrospective study was conducted in King Fahad Medical City, Riyadh, Saudi Arabia, in patients with pituitary tumours...
May 7, 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29858690/dexamethasone-related-adrenal-insufficiency-in-patients-with-brain-and-skull-base-tumours
#10
H Benghiat, P Sanghera, D Stange, P Nightingale, A Hartley, M W O'Reilly, N Nundall, H Currie, M Ali, G Cruickshank, D Spooner, A Toogood
PURPOSE: This study aimed to evaluate the prevalence of glucocorticoid-induced adrenal insufficiency in a cohort of patients with brain and skull base tumours and to identify factors which may predict its occurrence. METHODS: Patients with brain or skull base tumours attending for a short synacthen test (SST) (adrenocorticotropin hormone (ACTH) stimulation test) at a single institution over a 3-year period were retrospectively identified. Baseline demographics and dexamethasone exposure were examined...
June 1, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29749277/correlations-between-clinical-hormone-change-and-pathological-features-of-pituicytoma
#11
Ting-Wei Chang, Ching-Yi Lee, Shih-Ming Jung, Hung-Yi Lai, Chun-Ting Chen, Mun-Chun Yeap, Chi-Cheng Chuang, Peng-Wei Hsu, Chen-Nen Chang, Po-Hsun Tu, Shih-Tseng Lee
PURPOSE: Pituicytoma is a rare low-grade glioma arising from the pituicytes of the posterior pituitary. To date, the clinical and pathological correlates of pituicytoma have not been investigated. This study was thus designed to examine the correlation between pituicytoma and the normal pituitary gland. METHODS: The records of patients who underwent pituitary surgery at Chang Gung Memorial Hospital in Linkou, Taiwan between 2000 and 2016 were reviewed. Patients who received a pathological diagnosis of pituicytoma were included; however, those with inadequate specimens for pathological study were excluded...
May 11, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29732160/granular-cell-tumour-of-the-neurohypophysis-an-unusual-cause-of-hypopituitarism
#12
Carlos Tavares Bello, Patricia Cipriano, Vanessa Henriques, João Sequeira Duarte, Conceição Canas Marques
Granular cell tumours (GCT) are rare, slow-growing, benign neoplasms that are usually located in the head and neck. They are more frequent in the female gender and typically have an asymptomatic clinical course, being diagnosed only at autopsy. Symptomatic GCT of the neurohypophysis are exceedingly rare, being less than 70 cases described so far. The authors report on a case of a 28-year-old male that presented to the Endocrinology clinic with clinical and biochemical evidence of hypogonadism. He also reported minor headaches without any major visual symptoms...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29729370/reduced-protein-expression-of-the-phosphodiesterases-pde4a4-and-pde4a8-in-aip-mutation-positive-somatotroph-adenomas
#13
Mariana Ferreira Bizzi, Sergio Veloso Brant Pinheiro, Graeme B Bolger, Junia Ribeiro de Oliveira Longo Schweizer, Alexandre V Giannetti, Mary N Dang, Antonio Ribeiro-Oliveira, Márta Korbonits
Type 4 phosphodiesterases (PDE4s) of the large PDE enzyme superfamily have unique specificity for cAMP and may, therefore, be relevant for somatotroph tumorigenesis. Somatotroph adenomas typically overexpress PDEs probably as part of a compensatory mechanism to reduce cAMP levels. The rat PDE4A5 isoform (human homolog PDE4A4) interacts with the AIP protein, coded by a tumour suppressor gene mutated in a subgroup of familial isolated pituitary adenomas (FIPAs). PDE4A8 is the closest related isoform of PDE4A4...
May 3, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29712721/a-comparative-population-based-analysis-of-pituitary-incidentalomas-vs-clinically-manifesting-sellar-masses
#14
Nadine M Vaninetti, David B Clarke, Deborah A Zwicker, Churn-Ern Yip, Barna Tugwell, Steve Doucette, Chris Theriault, Khaled Aldahmani, Syed Ali Imran
PURPOSE: Sellar masses may present either with clinical manifestations of mass effect/hormonal dysfunction (CMSM) or incidentally on imaging (pituitary incidentaloma (PI)). This novel population-based study compares these two entities. METHODS: Retrospective analysis of all patients within a provincial pituitary registry between January 2006 and June 2014. RESULTS: Nine hundred and three patients were included (681 CMSM, 222 PI). CMSM mainly presented with secondary hormone deficiencies (SHDs) or stalk compression (29...
May 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29694715/evolution-of-pituitary-surgery-in-a-tertiary-centre
#15
LETTER
K J McNamara, T F C Saunders, A Darr, S Kumar, S Shaw, N Saravanappa
No abstract text is available yet for this article.
April 25, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29688280/the-occurrence-of-benign-brain-tumours-in-transgender-individuals-during-cross-sex-hormone-treatment
#16
Nienke M Nota, Chantal M Wiepjes, Christel J M de Blok, Louis J G Gooren, Saskia M Peerdeman, Baudewijntje P C Kreukels, Martin den Heijer
Benign brain tumours may be hormone sensitive. To induce physical characteristics of the desired gender, transgender individuals often receive cross-sex hormone treatment, sometimes in higher doses than hypogonadal individuals. To date, long-term (side) effects of cross-sex hormone treatment are largely unknown. In the present retrospective chart study we aimed to compare the incidence of common benign brain tumours: meningiomas, pituitary adenomas (non-secretive and secretive), and vestibular schwannomas in transgender individuals receiving cross-sex hormone treatment, with those reported in general Dutch or European populations...
April 23, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29671958/synoptic-reporting-of-pituitary-magnetic-resonance-imaging
#17
Rana S Dhillon, James A King, Tony Goldschlager, Yi Yuen Wang
BACKGROUND: Pituitary adenomas are common, often asymptomatic tumours that are diagnosed incidentally by magnetic resonance imaging (MRI) of the brain. There is considerable variation in the reporting of pituitary MRI, in part because there is no consensus as to what information should be included in such reports. Synoptic reporting consists of using structured checklists to standardize communication. It has been adopted in the surgical pathology literature and more recently in the breast imaging field...
May 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29670116/association-between-radiological-parameters-and-clinical-and-molecular-characteristics-in-human-somatotropinomas
#18
María R Alhambra-Expósito, Alejandro Ibáñez-Costa, Paloma Moreno-Moreno, Esther Rivero-Cortés, Mari C Vázquez-Borrego, Cristóbal Blanco-Acevedo, Álvaro Toledano-Delgado, María S Lombardo-Galera, Juan A Vallejo-Casas, Manuel D Gahete, Justo P Castaño, María A Gálvez, Raúl M Luque
Acromegaly is a rare but severe disease, originated in 95% of cases by a growth hormone-secreting adenoma (somatotropinoma) in the pituitary. Magnetic resonance imaging (MRI) is a non-invasive technique used for the diagnosis and prognosis of pituitary tumours. The aim of this study was to determine whether the use of T2-weighted signal intensity at MRI could help to improve the characterisation of somatotropinomas, by analysing its relationship with clinical/molecular features. An observational study was implemented in a cohort of 22 patients (mean age = 42...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29667493/non-adenomatous-pituitary-tumours-mimicking-functioning-pituitary-adenomas
#19
Zize Feng, Zhigang Mao, Zongming Wang, Bing Liao, Yonghong Zhu, Haijun Wang
OBJECTIVE: Pituicytomas and granular cell tumours (GCTs) of the neurohypophysis are considered non-adenomatous neoplasms in the sellar region. The association between hormone hypersecretion and the tumours is seldom discussed and unclear. Therefore, we attempt to investigate this association based on our experience and a review of the literature. METHODS: We report three patients who presented with Cushing's syndrome- or acromegaly-like symptoms at our institution...
April 18, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29663325/a-new-approach-to-the-treatment-of-acute-myeloid-leukaemia-targeting-the-receptor-for-growth-hormone-releasing-hormone
#20
Joaquin J Jimenez, Gina M DelCanto, Petra Popovics, Aymee Perez, Ailin Vila Granda, Irving Vidaurre, Ren-Zhi Cai, Ferenc G Rick, Ronan T Swords, Andrew V Schally
Growth hormone-releasing hormone (GHRH) is secreted by the hypothalamus and acts on the pituitary gland to stimulate the release of growth hormone (GH). GHRH can also be produced by human cancers, in which it functions as an autocrine/paracrine growth factor. We have previously shown that synthetic antagonistic analogues of GHRH are able to successfully suppress the growth of 60 different human cancer cell lines representing over 20 cancers. Nevertheless, the expression of GHRH and its receptors in leukaemias has never been examined...
May 2018: British Journal of Haematology
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