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https://www.readbyqxmd.com/read/29222637/coffee-consumption-and-risk-of-hypertension-a-dose-response-meta-analysis-of-prospective-studies
#1
Lanfranco D'Elia, Ersilia La Fata, Ferruccio Galletti, Luca Scalfi, Pasquale Strazzullo
PURPOSE: Recently, a large prospective study provided additional information concerning the debated possible association between habitual coffee consumption and risk of hypertension (HPT). Therefore, we updated the state of knowledge on this issue by carrying out a comprehensive new systematic review of the literature and a meta-analysis of the available relevant studies. METHODS: We performed a systematic search for prospective studies on general population, published without language restrictions (1966-August 2017)...
December 8, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/29222533/elastic-fibers-and-large-artery-mechanics
#2
M G Espinosa, Marius C Staiculescu, Jungsil Kim, Eric Marin, Jessica E Wagenseil
Development of a closed circulatory system requires that large arteries adapt to the mechanical demands of high, pulsatile pressure. Elastin and collagen uniquely address these design criteria in the low and high stress regimes, resulting in a nonlinear mechanical response. Elastin is the core component of elastic fibers, which provide the artery wall with energy storage and recoil. The integrity of the elastic fiber network is affected by component insufficiency or disorganization, leading to an array of vascular pathologies and compromised mechanical behavior...
December 9, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29222281/improved-biological-insight-and-influence-on-management-in-indolent-lymphoma-talk-3-update-on-nodal-and-splenic-marginal-zone-lymphoma
#3
REVIEW
Catherine Thieblemont
Splenic marginal zone lymphoma (SMZL) and nodal marginal zone lymphoma (NMZL) are rare indolent chronic B-cell lymphomas. Prognosis is typically good with median survival around 10-15 years. Management is generally based on the presence of symptoms or high tumor burden. There are no standard treatments for these 2 entities, and therapeutic strategies are rapidly evolving. Clinical developments for these 2 entities are oriented by genomic studies, with largely overlapping mutational profiles involving the NOTCH, B-cell receptor (BcR) and nuclear factor κB (NF-κB) signaling, chromatin remodeling, and the cytoskeleton...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29222076/adverse-drug-event-discovery-using-biomedical-literature-a-big-data-neural-network-adventure
#4
Ahmad P Tafti, Jonathan Badger, Eric LaRose, Ehsan Shirzadi, Andrea Mahnke, John Mayer, Zhan Ye, David Page, Peggy Peissig
BACKGROUND: The study of adverse drug events (ADEs) is a tenured topic in medical literature. In recent years, increasing numbers of scientific articles and health-related social media posts have been generated and shared daily, albeit with very limited use for ADE study and with little known about the content with respect to ADEs. OBJECTIVE: The aim of this study was to develop a big data analytics strategy that mines the content of scientific articles and health-related Web-based social media to detect and identify ADEs...
December 8, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/29220515/busco-applications-from-quality-assessments-to-gene-prediction-and-phylogenomics
#5
Robert M Waterhouse, Mathieu Seppey, Felipe A Simão, Mosè Manni, Panagiotis Ioannidis, Guennadi Klioutchnikov, Evgenia V Kriventseva, Evgeny M Zdobnov
Genomics promises comprehensive surveying of genomes and metagenomes, but rapidly changing technologies and expanding data volumes make evaluation of completeness a challenging task. Technical sequencing quality metrics can be complemented by quantifying completeness of genomic datasets in terms of the expected gene content of Benchmarking Universal Single-Copy Orthologs (BUSCO, http://busco.ezlab.org). The latest software release implements a complete refactoring of the code to make it more flexible and extendable to facilitate high-throughput assessments...
December 6, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29220464/kipho-malaria-parasite-kinome-and-phosphatome-portal
#6
Rajan Pandey, Pawan Kumar, Dinesh Gupta
The Plasmodium kinases and phosphatases play an essential role in the regulation of substrate reversible-phosphorylation and overall cellular homeostasis. Reversible phosphorylation is one of the key post-translational modifications (PTMs) essential for parasite survival. Thus, a complete and comprehensive information of malarial kinases and phosphatases as a single web resource will not only aid in systematic and better understanding of the PTMs, but also facilitate efforts to look for novel drug targets for malaria...
January 1, 2017: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/29220314/random-access-memories-a-new-paradigm-for-target-detection-in-high-resolution-aerial-remote-sensing-images
#7
Zhengxia Zou, Zhenwei Shi
We propose a new paradigm for target detection in high resolution aerial remote sensing images under small target priors. Previous remote sensing target detection methods frame the detection as learning of detection model + inference of class-label and bounding-box coordinates. Instead, we formulate it from a Bayesian view that at inference stage, the detection model is adaptively updated to maximize its posterior that is determined by both training and observation. We call this paradigm "random access memories (RAM)...
March 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29219096/meeting-new-canadian-24-hour-movement-guidelines-for-the-early-years-and-associations-with-adiposity-among-toddlers-living-in-edmonton-canada
#8
Eun-Young Lee, Kylie D Hesketh, Stephen Hunter, Nicholas Kuzik, Ryan E Rhodes, Christina M Rinaldi, John C Spence, Valerie Carson
BACKGROUND: Canada has recently released guidelines that include toddler-specific recommendations for physical activity, screen-based sedentary behaviour, and sleep. This study examined the proportions of toddlers meeting the new Canadian 24-Hour Movement Guidelines for the Early Years (0-4 years) and associations with body mass index (BMI) z-scores in a sample from Edmonton, Canada. METHODS: Participants included 151 toddlers (aged 19.0 ± 1.9 months) for whom there was complete objectively measured physical activity data from the Parents' Role in Establishing healthy Physical activity and Sedentary behaviour habits (PREPS) project...
November 20, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29218389/primary-prophylaxis-of-invasive-fungal-infections-in-patients-with-haematological-malignancies-2017-update-of-the-recommendations-of-the-infectious-diseases-working-party-agiho-of-the-german-society-for-haematology-and-medical-oncology-dgho
#9
REVIEW
Sibylle C Mellinghoff, Jens Panse, Nael Alakel, Gerhard Behre, Dieter Buchheidt, Maximilian Christopeit, Justin Hasenkamp, Michael Kiehl, Michael Koldehoff, Stefan W Krause, Nicola Lehners, Marie von Lilienfeld-Toal, Annika Y Löhnert, Georg Maschmeyer, Daniel Teschner, Andrew J Ullmann, Olaf Penack, Markus Ruhnke, Karin Mayer, Helmut Ostermann, Hans-H Wolf, Oliver A Cornely
Immunocompromised patients are at high risk of invasive fungal infections (IFI), in particular those with haematological malignancies undergoing remission-induction chemotherapy for acute myeloid leukaemia (AML) or myelodysplastic syndrome (MDS) and recipients of allogeneic haematopoietic stem cell transplants (HSCT). Despite the development of new treatment options in the past decades, IFI remains a concern due to substantial morbidity and mortality in these patient populations. In addition, the increasing use of new immune modulating drugs in cancer therapy has opened an entirely new spectrum of at risk periods...
December 7, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/29217694/updated-birth-weight-centiles-for-england-and-wales
#10
Tom Norris, Sarah E Seaton, Brad N Manktelow, Philip N Baker, Jennifer J Kurinczuk, David Field, Elizabeth S Draper, Lucy K Smith
OBJECTIVES: Construct updated birth weight-for-gestational age centile charts for use in the UK and compare these to the currently used UK-WHO charts. DESIGN: Secondary analysis of national birth data. PARTICIPANTS: Centiles were constructed using 1 269 403 singleton births occurring in England and Wales in 2013-2014 as part of the MBRRACE-UK national perinatal surveillance programme. These were then validated using 642 737 singleton births occurring in England and Wales in 2015...
December 7, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29217636/novel-united-kingdom-prognostic-model-for-30-day-mortality-following-transcatheter-aortic-valve-implantation
#11
Glen P Martin, Matthew Sperrin, Peter F Ludman, Mark A de Belder, Simon R Redwood, Jonathan N Townend, Mark Gunning, Neil E Moat, Adrian P Banning, Iain Buchan, Mamas A Mamas
OBJECTIVE: Existing clinical prediction models (CPM) for short-term mortality after transcatheter aortic valve implantation (TAVI) have limited applicability in the UK due to moderate predictive performance and inconsistent recording practices across registries. The aim of this study was to derive a UK-TAVI CPM to predict 30-day mortality risk for benchmarking purposes. METHODS: A two-step modelling strategy was undertaken: first, data from the UK-TAVI Registry between 2009 and 2014 were used to develop a multivariable logistic regression CPM using backwards stepwise regression...
December 7, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29217253/update-on-cardiovascular-implantable-electronic-devices-for-anesthesiologists
#12
REVIEW
Brett Cronin, Michael K Essandoh
With the advent of "wireless" endocardial pacing, the subcutaneous implantable cardioverter defibrillator, and leadless pacemakers comes an added layer of complexity to the perioperative management of cardiovascular implantable electronic devices (CIED). Since no formal recommendations currently exist for these new CIED technologies, preoperative identification of these devices, understanding their functionality, and developing an individualized perioperative management plan are imperative for the anesthesiologist...
September 7, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29216930/contacting-of-authors-by-systematic-reviewers-protocol-for-a-cross-sectional-study-and-a-survey
#13
Reint Meursinge Reynders, Luisa Ladu, Nicola Di Girolamo
BACKGROUND: Synthesizing outcomes of underreported primary studies can pose a serious threat to the validity of outcomes and conclusions of systematic reviews. To address this problem, the Cochrane Collaboration recommends reviewers to contact authors of eligible primary studies to obtain additional information on poorly reported items. In this protocol, we present a cross-sectional study and a survey to assess (1) how reviewers of new Cochrane intervention reviews report on procedures and outcomes of contacting of authors of primary studies to obtain additional data, (2) how authors reply, and (3) the consequences of these additional data on the outcomes and quality scores in the review...
December 8, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29216806/an-industry-update-the-latest-developments-in-therapeutic-delivery
#14
Iain Simpson
This industry update covers the period from 1 September through 30 September 2017, and is based on information sourced from company press releases, scientific literature, patents and various news websites. The month saw the US FDA approve three new molecular entities, Aliqopa (copanlisib dihydrochloride) (Bayer Healthcare); Solosec (secnidazole) (Symbiomix Therapeutics) and Verzenio (abemaciclib) (Eli Lilly and Co). Intarcia Therapeutics Inc. has its application for approval of a novel drug device combination of exenatide for the treatment of diabetes rejected by FDA but said that it will work to address the concerns and refile the application...
January 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/29216678/-guideline-for-the-diagnosis-and-treatment-of-asthma-guideline-of-the-german-respiratory-society-and-the-german-atemwegsliga-in-cooperation-with-the-paediatric-respiratory-society-and-the-austrian-society-of-pneumology
#15
R Buhl, R Bals, X Baur, D Berdel, C-P Criée, M Gappa, A Gillissen, T Greulich, P Haidl, E Hamelmann, P Kardos, K Kenn, L Klimek, S Korn, M Lommatzsch, H Magnussen, T Nicolai, D Nowak, O Pfaar, K F Rabe, J Riedler, T Ritz, K Schultz, A Schuster, T Spindler, R C Taube, K Taube, C Vogelmeier, A von Leupold, F Wantke, S Weise, J Wildhaber, H Worth, A Zacharasiewicz
The present guideline is a new version and an update of the guideline for the diagnosis and treatment of asthma, which replaces the previous version for german speaking countries from the year 2006. The wealth of new data on the pathophysiology and the phenotypes of asthma, and the expanded spectrum of diagnostic and therapeutic options necessitated a new version and an update. This guideline presents the current, evidence-based recommendations for the diagnosis and treatment of asthma, for children and adolescents as well as for adults with asthma...
December 2017: Pneumologie
https://www.readbyqxmd.com/read/29216496/the-impact-of-new-national-guidance-for-the-public-health-management-of-enteric-fever-in-england
#16
K Russell, S Addiman, D Grynszpan, J Freedman, J Lopez Bernal, Z Yin, C Rawlings, S Balasegaram
OBJECTIVES: New guidance was published in England in February 2012 to support the public health management of enteric fever and reduce the risks of secondary transmission. The new guidance was evaluated to assess: STUDY DESIGN: Quantitative and qualitative evaluation of the implementation of new public health guidance. METHODS: A qualitative review of all non-travel-related cases from February 2010 to January 2014 to compare the risk of secondary transmission before and after the guidance introduction; an audit of clearance sampling for each case and their contacts reported in London from February 2012-January 2015 to compare with a previous London audit; and an online user survey in November 2014...
December 4, 2017: Public Health
https://www.readbyqxmd.com/read/29215916/new-and-incremental-fda-black-box-warnings-from-2008-to-2015
#17
Michael T Solotke, Sanket S Dhruva, Nicholas S Downing, Nilay D Shah, Joseph S Ross
BACKGROUND: The boxed warning (also known as "black box warning [BBW]") is one of the strongest drug safety actions that the U.S. Food & Drug Administration (FDA) can implement, and often warns of serious risks. The objective of this study was to comprehensively characterize BBWs issued for drugs after FDA approval. METHODS: We identified all post-marketing BBWs from January 2008 through June 2015 listed on FDA's MedWatch and Drug Safety Communications websites...
December 7, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29215803/reference-values-for-spirometry-derived-using-lambda-mu-sigma-lms-method-in-korean-adults-in-comparison-with-previous-references
#18
Bum Seak Jo, Jun Pyo Myong, Chin Kook Rhee, Hyoung Kyu Yoon, Jung Wan Koo, Hyoung Ryoul Kim
BACKGROUND: The present study aimed to update the prediction equations for spirometry and their lower limits of normal (LLN) by using the lambda, mu, sigma (LMS) method and to compare the outcomes with the values of previous spirometric reference equations. METHODS: Spirometric data of 10,249 healthy non-smokers (8,776 females) were extracted from the fourth and fifth versions of the Korea National Health and Nutrition Examination Survey (KNHANES IV, 2007-2009; V, 2010-2012)...
January 15, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29215160/new-figo-and-swedish-intrapartum-cardiotocography-classification-systems-incorporated-in-the-fetal-ecg-st-analysis-stan-interpretation-algorithm-agreements-and-discrepancies-in-cardiotocography-classification-and-evaluation-of-significant-st-events
#19
Per Olofsson, Håkan Norén, Ann Carlsson
The updated intrapartum cardiotocography (CTG) classification system by FIGO in 2015 (FIGO2015) and the FIGO2015-approached classification by the Swedish Society of Obstetricians and Gynecologist in 2017 (SSOG2017) are not harmonized with the fetal ECG ST analysis (STAN) algorithm from 2007 (STAN2007). The study aimed to reveal homogeneity and agreement between the systems in classifying CTG and ST events, and relate to maternal and perinatal outcomes MATERIAL AND METHODS: Among CTG traces with ST events, 100 traces originally classified as normal, 100 as suspicious and 100 as pathological were randomly selected from a STAN database and classified by two experts in consensus...
December 7, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29214980/ion-chambers-compliance-results-of-brazilian-radiation-therapy-facilities
#20
Georgia Santos Joana, Camila Salata, Paulo Leal, Renato Oliveira, Nozimar do Couto, Flavia Cristina Teixeira, Abner Duarte Soares, Eduardo Sergio Santini, Marcello Gomes Gonçalves
Brazilian Nuclear Energy Commission (cnen) has been making a constant effort to keep updated with international standards and national needs to strengthen the status of radiological protection of the country. The guidelines related to radiation therapy facilities have been revised in the last five years in order to take in consideration the most relevant aspects of the growing technology as well as to mitigate the accidents or incidents observed in practice. Hence, clinical dosimeters have gained special importance in this matter...
December 7, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
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