Nicholas Howell, Ryan J Middleton, Frederic Sierro, Naomi A Wyatt, Andrew Chacon, Benjamin H Fraser, Keith R Bambery, Elle Livio, Christopher Dobie, Joseph J Bevitt, Justin Davies, Anthony Dosseto, Daniel R Franklin, Ulf Garbe, Susanna Guatelli, Ryoichi Hirayama, Naruhiro Matsufuji, Akram Mohammadi, Karl Mutimer, Louis M Rendina, Anatoly B Rosenfeld, Mitra Safavi-Naeini
PURPOSE: Neutron Capture Enhanced Particle Therapy (NCEPT) is a proposed augmentation of charged particle therapy which exploits thermal neutrons generated internally, within the treatment volume via nuclear fragmentation, to deliver a biochemically targeted radiation dose to cancer cells. This work is the first experimental demonstration of NCEPT, performed using both carbon and helium ion beams with two different targeted neutron capture agents (NCAs). MATERIALS AND METHODS: Human glioblastoma cells (T98G) were irradiated by carbon and helium ion beams in the presence of NCAs, [10 B]-BPA and [157 Gd]-DOTA-TPP...
March 11, 2024: International Journal of Radiation Oncology, Biology, Physics