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PARTICLE BEAM THERAPY

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https://www.readbyqxmd.com/read/28809759/independent-dose-verification-system-with-monte-carlo-simulations-using-topas-for-passive-scattering-proton-therapy-at-the-national-cancer-center-in-korea
#1
Wook-Geun Shin, Mauro Testa, Hak Soo Kim, Jong Hwi Jeong, Se Byeong Lee, Yeon-Joo Kim, Chul Hee Min
For the independent validation of treatment plans, we developed a Monte Carlo (MC)-based patient dose calculation system with the tool for particle simulation (TOPAS) to enable routine and automatic dose recalculation for each patient. The proton beam nozzle was modeled with TOPAS to simulate the therapeutic beam, and MC commissioning was performed by comparing percent depth dose with the measurement. The beam set-up based on the prescribed beam range and modulation width was automated by modifying the vendor-specific method...
August 15, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28770316/hepatic-arterial-embolization-using-cone-beam-ct-with-tumor-feeding-vessel-detection-software-impact-on-hepatocellular-carcinoma-response
#2
F H Cornelis, A Borgheresi, E N Petre, E Santos, S B Solomon, K Brown
PURPOSE: Dedicated tumor feeding vessel detection software (TFVDS) using cone beam CT has shown a higher sensitivity to detect tumor feeding vessels during hepatic arterial embolization (HAE) of hepatocellular carcinoma (HCC) compared to 2D imaging. Our primary hypothesis was that HCC tumors treated with HAE guided by a TFVDS would show more complete response (CR) than when treated with 2D imaging alone. Secondary analysis of the impact on X-ray exposure was performed. MATERIALS AND METHODS: Nineteen males and 8 females (median age: 69 year, 46-85) with 44 tumors (median size: 38 mm, 6-100) treated with selective HAE between January 2013 and December 2014 were included...
August 2, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28764925/profile-of-european-proton-and-carbon-ion-therapy-centers-assessed-by-the-eortc-facility-questionnaire
#3
Damien C Weber, André Abrunhosa-Branquinho, Alessandra Bolsi, Andrzej Kacperek, Rémi Dendale, Dirk Geismar, Barbara Bachtiary, Annika Hall, Jens Heufelder, Klaus Herfarth, Jürgen Debus, Maurizio Amichetti, Mechthild Krause, Roberto Orecchia, Vladimir Vondracek, Juliette Thariat, Tomasz Kajdrowicz, Kristina Nilsson, Cai Grau
BACKGROUND: We performed a survey using the modified EORTC Facility questionnaire (pFQ) to evaluate the human, technical and organizational resources of particle centers in Europe. MATERIAL AND METHODS: The modified pFQ consisted of 235 questions distributed in 11 sections accessible on line on an EORTC server. Fifteen centers from 8 countries completed the pFQ between May 2015 and December 2015. RESULTS: The average number of patients treated per year and per particle center was 221 (range, 40-557)...
July 29, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28762335/helium-ions-at-the-heidelberg-ion-beam-therapy-center-comparisons-between-fluka-monte-carlo-code-predictions-and-dosimetric-measurements
#4
T Tessonnier, A Mairani, S Brons, P Sala, F Cerutti, A Ferrari, T Haberer, J Debus, K Parodi
In the field of particle therapy helium ion beams could offer an alternative for radiotherapy treatments, owing to their interesting physical and biological properties intermediate between protons and carbon ions. We present in this work the comparisons and validations of the Monte Carlo FLUKA code against in-depth dosimetric measurements acquired at the Heidelberg Ion Beam Therapy Center (HIT). Depth dose distributions in water with and without ripple filter, lateral profiles at different depths in water and a spread-out Bragg peak were investigated...
August 1, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28758407/radiation-for-skull-base-meningiomas-review-of-the-literature-on-the-approach-to-radiotherapy
#5
Fabio Y Moraes, Caroline Chung
Skull base meningiomas (SBM) pose unique challenges for radiotherapy as these tumors are often in close proximity to a number of critical structures and may not be surgically addressed in many cases, leaving the question about the tumor grade and expected biological behaviour. External beam radiotherapy and radiosurgery are longstanding treatments for meningioma that are typically used as upfront primary therapy, for recurrent tumors and as adjuvant therapy following surgical resection. There is controversy regarding the optimal timing and approach for radiation therapy in various clinical settings such as the role of adjuvant radiotherapy for completely resected grade 2 tumours...
July 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28741595/3d-range-modulator-for-scanned-particle-therapy-development-monte-carlo-simulations-and-experimental-evaluation
#6
Yuri Simeonov, Uli Weber, Petar Penchev, Toke Printz Ringbæk, Christoph Schuy, Stephan Brons, Rita Engenhart-Cabillic, Jens Bliedtner, Klemens Zink
The purpose of this work was to design and manufacture a 3D range-modulator for scanned particle therapy. The modulator is intended to create a highly conformal dose distribution with only one fixed energy, simultaneously reducing considerably the treatment time. As a proof of concept, a 3D range-modulator was developed for a spherical target volume with a diameter of 5 cm, placed at a depth of 25 cm in a water phantom. It consists of a large number of thin pins with a well-defined shape and different lengths to modulate the necessary shift of the Bragg peak...
August 11, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28698432/-treatment-strategy-for-soft-tissue-sarcomas
#7
Akihiko Matsumine
Surgical excision is the most reliable treatment for the localized soft tissue sarcoma, and chemotherapy and/or radiation therapy may be recommended as adjuvant therapy, depending on the histologic type, grading, tumor size and location. For the unresectable tumors, radiation therapy including particle beam radiation therapy may be taken into consideration. For the recurrent or metastatic disease, the combination therapy with chemotherapy, radiation therapy and surgical excision may be indicated to improve the patient's prognosis and QOL...
June 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28650846/dosimetric-verification-in-water-of-a-monte-carlo-treatment-planning-tool-for-proton-helium-carbon-and-oxygen-ion-beams-at-the-heidelberg-ion-beam-therapy-center
#8
T Tessonnier, T T Böhlen, F Ceruti, A Ferrari, P Sala, S Brons, T Haberer, J Debus, K Parodi, A Mairani
The introduction of 'new' ion species in particle therapy needs to be supported by a thorough assessment of their dosimetric properties and by treatment planning comparisons with clinically used proton and carbon ion beams. In addition to the latter two ions, helium and oxygen ion beams are foreseen at the Heidelberg Ion Beam Therapy Center (HIT) as potential assets for improving clinical outcomes in the near future. We present in this study a dosimetric validation of a FLUKA-based Monte Carlo treatment planning tool (MCTP) for protons, helium, carbon and oxygen ions for spread-out Bragg peaks in water...
July 31, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28635614/advanced-treatment-planning-using-direct-4d-optimisation-for-pencil-beam-scanned-particle-therapy
#9
Kinga Bernatowicz, Ye Zhang, Rosalind Perrin, Damien C Weber, Antony J Lomax
We report on development of a new four-dimensional (4D) optimisation approach for scanned proton beams, which incorporates both irregular motion patterns and the delivery dynamics of the treatment machine into the plan optimiser. Furthermore, we assess the effectiveness of this technique to reduce dose to critical structures in proximity to moving targets, while maintaining effective target dose homogeneity and coverage. The proposed approach has been tested using both a simulated phantom and a clinical liver cancer case, and allows for realistic 4D calculations and optimisation using irregular breathing patterns extracted from e...
July 31, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28619756/alpha-particle-enhanced-blood-brain-tumor-barrier-permeabilization-in-glioblastomas-using-integrin-alpha-v-beta-3-targeted-liposomes
#10
Anirudh Sattiraju, Xiaobing Xiong, Darpan N Pandya, Thaddeus J Wadas, Ang Xuan, Yao Sun, Youngkyoo Jung, Kiran Kumar Solingapuram Sai, Jay F Dorsey, King C Li, Akiva Mintz
<span style="font-size: 11.0pt; line-height: 200%; color: windowtext;">Glioblastoma (GBM) is the most common primary malignant astrocytoma characterized by extensive invasion, angiogenesis, hypoxia and micrometastasis. Despite the relatively leaky nature of GBM blood vessels, effective delivery of anti-tumor therapeutics has been a major challenge due to the complications caused by the blood brain barrier (BBB) and the highly torturous nature of newly formed tumor vasculature (blood tumor barrier-BTB)...
June 15, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28603224/proton-beam-therapy-for-pediatric-brain-tumor
#11
Masashi Mizumoto, Yoshiko Oshiro, Tetsuya Yamamoto, Hidehiro Kohzuki, Hideyuki Sakurai
Cancer is a major cause of childhood death, with central nervous system (CNS) neoplasms being the second most common pediatric malignancy, following hematological cancer. Treatment of pediatric CNS malignancies requires multimodal treatment using a combination of surgery, chemotherapy, and radiotherapy, and advances in these treatments have given favorable results and longer survival. However, treatment-related toxicities have also occurred, particularly for radiotherapy, after which secondary cancer, reduced function of irradiated organs, and retarded growth are significant problems...
June 9, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/28599495/investigation-of-the-relative-biological-effectiveness-and-uniform-isobiological-killing-effects-of-irradiation-with-a-clinical-carbon-sobp-beam-on-dna-repair-deficient-cho-cells
#12
Shigeaki Sunada, Ian M Cartwright, Hirokazu Hirakawa, Akira Fujimori, Mitsuru Uesaka, Takamitsu A Kato
Spread-out Bragg peak (SOBP) C ions have been used clinically in charged particle radiation therapy for years. An SOBP beam consists of various monoenergetic Bragg peaks; however, the biological effect of irradiation with an SOBP beam track has not been well-studied. In order to determine the clinically prospective molecular targets, radiosensitivity to the beam track in DNA repair deficient cell lines was investigated. A total of four distinct Chinese hamster ovary (CHO) cell lines, including CHO10B2 (wild-type), V3 (protein kinase DNA-activated catalytic polypeptide deficient), 51D1 (RAD51 paralog D deficient) and PADR9 [poly(ADP-ribose) polymerase (PARP) deficient], were irradiated with gamma-rays, C ions (290 MeV/n) and Fe ions (500 MeV/n), in order to compare cellular lethality...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28592116/radionuclides-in-radiation-induced-bystander-effect-may-it-share-in-radionuclide-therapy
#13
M Widel
For many years in radiobiology and radiotherapy predominated the conviction that cellular DNA is the main target for ionizing radiation, however, the view has changed in the past 20 years. Nowadays, it is assumed that not only directed (targeted) radiation effect, but also an indirect (non-targeted) effect may contribute to the result of radiation treatment. Non-targeted effect is relatively well recognized after external beam irradiation in vitro and in vivo, and comprises such phenomena like radiation-induced bystander effect (RIBE), genomic instability, adaptive response and abscopal (out of field) effect...
June 8, 2017: Neoplasma
https://www.readbyqxmd.com/read/28591006/assessment-of-functional-liver-reserve-old-and-new-in-99mtc-sulfur-colloid-scintigraphy
#14
Manuela M Matesan, Stephen R Bowen, Tobias R Chapman, Robert S Miyaoka, James W Velez, Michele F Wanner, Matthew J Nyflot, Smith Apisarnthanarax, Hubert J Vesselle
PURPOSE: A semiquantitative assessment of hepatic reticuloendothelial system function using colloidal particles scintigraphy has been proposed previously as a surrogate for liver function evaluation. In this article, we present an updated method for the overall assessment of technetium-99m (Tc)-sulfur colloid (SC) biodistribution that combines information from planar and attenuation-corrected Tc-SC single-photon emission computed tomography (SPECT) images. The imaging protocol described here was developed as an easy-to-implement method to assess overall and regional liver function changes associated with chronic liver disease...
June 6, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28586136/benchmarking-geant4-hadronic-models-for-prompt-%C3%AE-monitoring-in-carbon-ion%C3%A2-therapy
#15
Marie Vanstalle, Ilaria Mattei, Alessio Sarti, Fabio Bellini, Fabiano Bini, Francesco Collamati, Erika De Lucia, Marco Durante, Riccardo Faccini, Fernando Ferroni, Christian Finck, Salvatore Fiore, Michela Marafini, Vincenzo Patera, Luca Piersanti, Marta Rovituso, Christoph Schuy, Adalberto Sciubba, Giacomo Traini, Cecilia Voena, Chiara La Tessa
PURPOSE: The real-time monitoring of the spread-out Bragg peak would allow the planned dose delivered during treatment to be directly verified, but this poses a major challenge in modern ion beam therapy. A possible method to achieve this goal is to exploit the production of secondary particles by the nuclear reactions of the beam with the patient and correlate their emission profile to the planned target volume position. In this study, we present both the production rate and energy spectra of the prompt-γ produced by the interactions of the (12) C ion beam with a polymethyl methacrylate (PMMA) target...
August 2017: Medical Physics
https://www.readbyqxmd.com/read/28581404/treatment-related-toxicity-in-patients-with-early-stage-non-small-cell-lung-cancer-and-coexisting-interstitial-lung-disease-a-systematic-review
#16
REVIEW
Hanbo Chen, Suresh Senan, Esther J Nossent, R Gabriel Boldt, Andrew Warner, David A Palma, Alexander V Louie
PURPOSE: Definitive treatment for patients with early-stage non-small cell lung cancer (ES-NSCLC) is usually well tolerated. Patients with ES-NSCLC and coexisting interstitial lung disease (ILD) are at increased risk of severe treatment-related toxicity after definitive therapy. The main objective of this systematic review is to provide a pooled estimation of treatment-related mortality and ILD-specific toxicity in this population of patients and to identify trends for further study. METHODS AND MATERIALS: The MEDLINE and Embase databases were queried from respective dates of inception to January 2016...
July 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28557800/lateral-variations-of-radiobiological-properties-of-therapeutic-fields-of-sup-1-sup-h-sup-4-sup-he-sup-12-sup-c-and-sup-16-sup-o-ions-studied-with-geant4-and-microdosimetric-kinetic-model
#17
Sophie Dewey, Lucas Burigo, Igor A Pshenichnov, Igor Mishustin, Marcus Bleicher
As known, in cancer therapy with ion beams the relative biological effectiveness (RBE) of ions changes in the course of their propagation in tissues. Such changes are caused not only by increasing the linear energy transfer (LET) of beam particles with the penetration depth towards the Bragg peak, but also by nuclear reactions induced by beam nuclei leading to the production of various secondary particles. Although the changes of RBE along the beam axis have been studied quite well, much less attention has been paid to the evolution of RBE in the transverse direction, perpendicular to the beam axis...
May 30, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28554507/track-structure-model-of-microscopic-energy-deposition-by-protons-and-heavy-ions-in-segments-of-neuronal-cell-dendrites-represented-by-cylinders-or-spheres
#18
Murat Alp, Francis A Cucinotta
Changes to cognition, including memory, following radiation exposure are a concern for cosmic ray exposures to astronauts and in Hadron therapy with proton and heavy ion beams. The purpose of the present work is to develop computational methods to evaluate microscopic energy deposition (ED) in volumes representative of neuron cell structures, including segments of dendrites and spines, using a stochastic track structure model. A challenge for biophysical models of neuronal damage is the large sizes (> 100µm) and variability in volumes of possible dendritic segments and pre-synaptic elements (spines and filopodia)...
May 2017: Life Sciences in Space Research
https://www.readbyqxmd.com/read/28547820/future-of-medical-physics-real-time-mri-guided-proton-therapy
#19
Bradley M Oborn, Stephen Dowdell, Peter E Metcalfe, Stuart Crozier, Radhe Mohan, Paul J Keall
With the recent clinical implementation of real-time MRI-guided x-ray beam therapy (MRXT), attention is turning to the concept of combining real-time MRI guidance with proton beam therapy; MRI-guided proton beam therapy (MRPT). MRI guidance for proton beam therapy is expected to offer a compelling improvement to the current treatment workflow which is warranted arguably more than for x-ray beam therapy. This argument is born out of the fact that proton therapy toxicity outcomes are similar to that of the most advanced IMRT treatments, despite being a fundamentally superior particle for cancer treatment...
August 2017: Medical Physics
https://www.readbyqxmd.com/read/28545956/comparison-of-particle-beam-therapy-and-stereotactic-body-radiotherapy-for-early-stage-non-small-cell-lung-cancer-a-systematic-review-and-hypothesis-generating-meta-analysis
#20
REVIEW
Alexander Chi, Haiquan Chen, Sijin Wen, Haijuan Yan, Zhongxing Liao
PURPOSE: To assess hypo-fractionated particle beam therapy (PBT)'s efficacy relative to that of photon stereotactic body radiotherapy (SBRT) for early stage (ES) non-small cell lung cancer (NSCLC). METHODS: Eligible studies were identified through extensive searches of the PubMed, Medline, Google-scholar, and Cochrane library databases from 2000 to 2016. Original English publications of ES NSCLC were included. A meta-analysis was performed to compare the survival outcome, toxicity profile, and patterns of failure following each treatment...
June 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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