Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Monika Novak Babič, Sara Ragucci, Adrijana Leonardi, Miha Pavšič, Nicola Landi, Igor Križaj, Nina Gunde-Cimerman, Kristina Sepčić, Antimo Di Maro
Sodin 5 is a type 1 ribosome-inactivating protein isolated from the seeds of Salsola soda L., an edible halophytic plant that is widespread in southern Europe, close to the coast. This plant, known as 'agretti', is under consideration as a new potential crop on saline soils. Considering a possible defence role of sodin 5 in the plant, we report here its antifungal activity against different halophilic and halotolerant fungi. Our results show that sodin 5 at a concentration of 40 µg/mL (1.4 µM) was able to inhibit the growth of the fungi Trimmatostromma salinum (35...
March 12, 2024: Biomolecules
#2
JOURNAL ARTICLE
Sara Ragucci, Veronica Russo, Angela Clemente, Maria Giuseppina Campanile, Maria Antonietta Oliva, Nicola Landi, Paolo Vincenzo Pedone, Antonietta Arcella, Antimo Di Maro
Ribosome inactivating proteins (RIPs) are specific N-β-glycosylases that are well-characterized in plants. Their enzymatic action is to damage ribosomes, thereby blocking protein translation. Recently, several research groups have been working on the screening for these toxins in edible plants to facilitate the use of RIPs as biotechnological tools and biopesticides and to overcome public prejudice. Here, four novel monomeric (type 1) RIPs have been isolated from the seeds of Atriplex hortensis L. var...
March 4, 2024: Toxins
#3
Lindsay B Kilburn, Dong-Anh Khuong-Quang, Jordan R Hansford, Daniel Landi, Jasper van der Lugt, Sarah E S Leary, Pablo Hernáiz Driever, Simon Bailey, Sébastien Perreault, Geoffrey McCowage, Angela J Waanders, David S Ziegler, Olaf Witt, Patricia A Baxter, Hyoung Jin Kang, Timothy E Hassall, Jung Woo Han, Darren Hargrave, Andrea T Franson, Michal Yalon Oren, Helen Toledano, Valérie Larouche, Cassie Kline, Mohamed S Abdelbaki, Nada Jabado, Nicholas G Gottardo, Nicolas U Gerber, Nicholas S Whipple, Devorah Segal, Susan N Chi, Liat Oren, Enrica E K Tan, Sabine Mueller, Izzy Cornelio, Lisa McLeod, Xin Zhao, Ashley Walter, Daniel Da Costa, Peter Manley, Samuel C Blackman, Roger J Packer, Karsten Nysom
No abstract text is available yet for this article.
March 11, 2024: Nature Medicine
#4
JOURNAL ARTICLE
Filomena Mottola, Sara Ragucci, Maria Carannante, Nicola Landi, Rosaria Scudiero, Antimo Di Maro, Lucia Rocco
BACKGROUND: Ribosome inactivating proteins (RIPs) are N-glycosylases found in various plants that are able to specifically and irreversibly inhibit protein translation, thereby leading to cell death. Their cytotoxic properties have attracted attention in the medical field in the context of developing new anticancer therapies. Quinoin is a novel toxic enzyme obtained from quinoa seeds and classified as a type 1 RIP ( Chenopodium quinoa Willd.). Recently, quinoin was found to be cytotoxic to normal fibroblasts and keratinocytes in vitro , as well as to several tumor cell lines...
February 4, 2024: Frontiers in Bioscience (Landmark Edition)
#5
JOURNAL ARTICLE
Antonio D'Errico, Rosarita Nasso, Antimo Di Maro, Nicola Landi, Angela Chambery, Rosita Russo, Stefania D'Angelo, Mariorosario Masullo, Rosaria Arcone
BACKGROUND: Alzheimer's disease (AD) and Parkinson's disease (PD) are multifactorial neurodegenerative disorders that are mostly treated with drugs inhibiting key enzymes of cholinergic and aminergic neurotransmission, such as acetyl and butyryl cholinesterase (AChE, BuChE) or monoamine oxidases (MAO)-A/B, and of A β 1-40 aggregation. Diet plant components with multitarget functions are promising compounds in the prevention of AD and PD. Our aim was to identify neuroprotective compounds from Annurca apple polyphenol extract (AFPE)...
January 19, 2024: Nutrients
#6
JOURNAL ARTICLE
Brandon J Coombes, Isotta Landi, Karmel W Choi, Kritika Singh, Brian Fennessy, Greg D Jenkins, Anthony Batzler, Richard Pendegraft, Nicolas A Nunez, Y Nina Gao, Euijung Ryu, Priya Wickramaratne, Myrna M Weissman, Jyotishman Pathak, J John Mann, Jordan W Smoller, Lea K Davis, Mark Olfson, Alexander W Charney, Joanna M Biernacka
BACKGROUND: Depression and anxiety are common and highly comorbid, and their comorbidity is associated with poorer outcomes posing clinical and public health concerns. We evaluated the polygenic contribution to comorbid depression and anxiety, and to each in isolation. METHODS: Diagnostic codes were extracted from electronic health records for four biobanks [ N = 177 865 including 138 632 European (77.9%), 25 612 African (14.4%), and 13 621 Hispanic (7.7%) ancestry participants]...
November 2023: Psychological Medicine
#7
JOURNAL ARTICLE
Luigi Barbato, Nicola Discepoli, Marco Clementini, Ivo Iavicoli, Luca Landi, Vilma Pinchi, Mario Raspini, Maria Di Martino, Raffaele Cavalcanti, Alessandro Crea, Rodolfo Gianserra, Francesco Cairo, Nicola Marco Sforza
OBJECTIVE: To evaluate the impact of COVID-19 pandemic among a sample of Italian dentists in terms of infection, strategies for infection control, organization of the dental clinic, attitude, and behavior. MATERIAL AND METHODS: This was a cross-sectional survey. The sample consisted of 8000 Italian dentists selected among 63,375 using a computerized random sampling method. An electronic informed consent had to be signed. The questionnaire categories were on demographic, infection risk management, organization, and dentists' attitude and behavior...
November 27, 2023: Oral Diseases
#8
JOURNAL ARTICLE
Giulia Melinda Furlanis, Jacopo Favaro, Nicola Bresolin, Daniele Grioni, Valentina Baro, Alberto D'Amico, Stefano Sartori, Luca Denaro, Andrea Landi
BACKGROUND: Status epilepticus is a life-threatening condition that is defined as refractory (RSE) when the seizure activity continues despite treatment with benzodiazepine and a second appropriate treatment. Super refractory status epilepticus (SRSE) is an RSE that persists or recurs for ≥24 h. Few papers have reported the outcomes of pediatric patients affected by RSE and SRSE and treated with neuromodulation therapies. Vagus nerve stimulation (VNS) is an approved treatment for drug-resistant epilepsy...
November 14, 2023: Brain Sciences
#9
JOURNAL ARTICLE
Lindsay B Kilburn, Dong-Anh Khuong-Quang, Jordan R Hansford, Daniel Landi, Jasper van der Lugt, Sarah E S Leary, Pablo Hernáiz Driever, Simon Bailey, Sébastien Perreault, Geoffrey McCowage, Angela J Waanders, David S Ziegler, Olaf Witt, Patricia A Baxter, Hyoung Jin Kang, Timothy E Hassall, Jung Woo Han, Darren Hargrave, Andrea T Franson, Michal Yalon Oren, Helen Toledano, Valérie Larouche, Cassie Kline, Mohamed S Abdelbaki, Nada Jabado, Nicholas G Gottardo, Nicolas U Gerber, Nicholas S Whipple, Devorah Segal, Susan N Chi, Liat Oren, Enrica E K Tan, Sabine Mueller, Izzy Cornelio, Lisa McLeod, Xin Zhao, Ashley Walter, Daniel Da Costa, Peter Manley, Samuel C Blackman, Roger J Packer, Karsten Nysom
BRAF genomic alterations are the most common oncogenic drivers in pediatric low-grade glioma (pLGG). Arm 1 (n = 77) of the ongoing phase 2 FIREFLY-1 (PNOC026) trial investigated the efficacy of the oral, selective, central nervous system-penetrant, type II RAF inhibitor tovorafenib (420 mg m- 2 once weekly; 600 mg maximum) in patients with BRAF-altered, relapsed/refractory pLGG. Arm 2 (n = 60) is an extension cohort, which provided treatment access for patients with RAF-altered pLGG after arm 1 closure...
November 17, 2023: Nature Medicine
#10
JOURNAL ARTICLE
Fabio Ausania, Filippo Landi, Carolina González-Abós, John B Martinie, Dionisios Vrochides, Matthew Walsh, Shanaz M Hossain, Steven White, Viswakumar Prabakaran, Laleh G Melstrom, Yuman Fong, Valentina Valle, Yuntao Bing, Dianrong Xiu, Gregorio Di Franco, Nicola De' Angelis, Alexis Laurent, Giuseppe Giuliani, Graziano Pernazza, Riccardo Memeo, José Rios, Andrea Coratti, Luca Morelli, Pier C Giulianotti
BACKGROUND: Robotic distal pancreatectomy (RDP) is associated with a lower conversion rate and less blood loss than laparoscopic distal pancreatectomy (LDP). LDP has similar oncological outcomes as open surgery in PDAC. The aim of this study was to compare perioperative and oncological outcomes in obese patients with RDP versus LDP for PDAC. MATERIALS AND METHODS: Retrospectively, all obese patients who underwent RDP or LDP for PDAC between 2012 and 2022 at 12 international expert centres were included...
November 8, 2023: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
#11
JOURNAL ARTICLE
Patrizio Giacomini, Fabio Valenti, Matteo Allegretti, Matteo Pallocca, Francesca De Nicola, Ludovica Ciuffreda, Maurizio Fanciulli, Stefano Scalera, Simonetta Buglioni, Elisa Melucci, Beatrice Casini, Mariantonia Carosi, Edoardo Pescarmona, Elena Giordani, Francesca Sperati, Nicoletta Jannitti, Martina Betti, Marcello Maugeri-Saccà, Fabiana Letizia Cecere, Veronica Villani, Andrea Pace, Marialuisa Appetecchia, Patrizia Vici, Antonella Savarese, Eriseld Krasniqi, Virginia Ferraresi, Michelangelo Russillo, Alessandra Fabi, Lorenza Landi, Gabriele Minuti, Federico Cappuzzo, Massimo Zeuli, Gennaro Ciliberto
BACKGROUND: Molecular Tumor Boards (MTB) operating in real-world have generated limited consensus on good practices for accrual, actionable alteration mapping, and outcome metrics. These topics are addressed herein in 124 MTB patients, all real-world accrued at progression, and lacking approved therapy options. METHODS: Actionable genomic alterations identified by tumor DNA (tDNA) and circulating tumor DNA (ctDNA) profiling were mapped by customized OncoKB criteria to reflect diagnostic/therapeutic indications as approved in Europe...
October 16, 2023: Journal of Translational Medicine
#12
JOURNAL ARTICLE
Sara Ragucci, Nicola Landi, Lucía Citores, Rosario Iglesias, Rosita Russo, Angela Clemente, Michele Saviano, Paolo Vincenzo Pedone, Angela Chambery, José Miguel Ferreras, Antimo Di Maro
Ribotoxin-like proteins (RL-Ps) are specific ribonucleases found in mushrooms that are able to cleave a single phosphodiester bond located in the sarcin-ricin loop (SRL) of the large rRNA. The cleaved SRL interacts differently with some ribosomal proteins (P-stalk). This action blocks protein synthesis because the damaged ribosomes are unable to interact with elongation factors. Here, the amino acid sequences of eryngitin 3 and 4, RL-Ps isolated from Pleurotus eryngii fruiting bodies, were determined to (i) obtain structural information on this specific ribonuclease family from edible mushrooms and (ii) explore the structural determinants which justify their different biological and antipathogenic activities...
September 22, 2023: International Journal of Molecular Sciences
#13
JOURNAL ARTICLE
Sara Ragucci, Stefany Castaldi, Nicola Landi, Rachele Isticato, Antimo Di Maro
Ageritin from poplar mushrooms is a specific endonuclease that hydrolyzes a single phosphodiester bond located in the sarcin-ricin loop (SRL) of the large rRNA, thereby blocking protein synthesis. Considering the possible biotechnological use of this enzyme, here we report its antifungal activity against virulent fungi affecting crops of economic interest. Our results show that ageritin (200 µg/plug; ~13.5 nmole) inhibits the growth of Botrytis cinerea (57%), Colletotrichum truncatum (42%), and Alternaria alternata (57%), when tested on potato dextrose agar plates...
September 18, 2023: Toxins
#14
JOURNAL ARTICLE
Fabio Ausania, Filippo Landi, John B Martinie, Dionisios Vrochides, Matthew Walsh, Shanaz M Hossain, Steven White, Viswakumar Prabakaran, Laleh G Melstrom, Yuman Fong, Giovanni Butturini, Laura Bignotto, Valentina Valle, Yuntao Bing, Dianrong Xiu, Gregorio Di Franco, Francisco Sanchez-Bueno, Nicola de'Angelis, Alexis Laurent, Giuseppe Giuliani, Graziano Pernazza, Alessandro Esposito, Roberto Salvia, Francesca Bazzocchi, Ludovica Esposito, Andrea Pietrabissa, Luigi Pugliese, Riccardo Memeo, Ichiro Uyama, Yuichiro Uchida, José Rios, Andrea Coratti, Luca Morelli, Pier C Giulianotti
BACKGROUND: Although robotic distal pancreatectomy (RDP) has a lower conversion rate to open surgery and causes less blood loss than laparoscopic distal pancreatectomy (LDP), clear evidence on the impact of the surgical approach on morbidity is lacking. Prior studies have shown a higher rate of complications among obese patients undergoing pancreatectomy. The primary aim of this study is to compare short-term outcomes of RDP vs. LDP in patients with a BMI ≥ 30...
September 15, 2023: Surgical Endoscopy
#15
JOURNAL ARTICLE
Giulia Melinda Furlanis, Francesco Fascetti Leon, Nicola Bresolin, Jacopo Favaro, Valentina Baro, Alberto D'Amico, Luca Denaro, Stefano Sartori, Andrea Landi
INTRODUCTION: Vagus nerve stimulation (VNS) is a neuromodulation therapy for drug-resistant epilepsy (DRE), refractory status epilepticus, and treatment-resistant depression. The lead is tunneled into the subcutaneous space and connected to the generator, which is usually implanted in a subcutaneous pocket below the clavicle. Surgical complications in the chest region include skin breakdown or infection. An alternative approach is to perform a subclavear subpectoral implantation. In our surgical series, we report a new aesthetic implantation method for VNS generators in children and young patients: the transaxillary subpectoral placement...
September 4, 2023: Epilepsy & Behavior: E&B
#16
JOURNAL ARTICLE
Vito Laterza, Marcello Covino, Carlo Alberto Schena, Andrea Russo, Sara Salini, Davide Della Polla, Nicola de'Angelis, Giuseppe Quero, Vincenzo Tondolo, Antonio La Greca, Giuseppe Merra, Gabriele Sganga, Antonio Gasbarrini, Francesco Franceschi, Francesco Landi, Sergio Alfieri, Fausto Rosa
BACKGROUND: SBO is a potentially life-threatening condition that often affects older patients. Frailty, more than age, is expected to play a crucial role in predicting SBO prognosis in this population. This study aims to define the influence of Clinical Frailty Scale (CFS) on mortality and major complications in patients ≥80 years with diagnosis of SBO at the emergency department (ED). METHODS: All patients aged ≥80 years admitted to our ED for SBO from January 2015 to September 2020 were enrolled...
September 6, 2023: Journal of Gastrointestinal Surgery
#17
JOURNAL ARTICLE
Rebecca Sipione, Nicolas Liaudet, Francis Rousset, Basile N Landis, Julien Wen Hsieh, Pascal Senn
One of the most prevalent causes of olfactory loss includes traumatic brain injury with subsequent shearing of olfactory axons at the level of the cribriform plate (anterior skull base). Scar tissue at this level may prevent axonal regrowth toward the olfactory bulb. Currently, there is no cure for this debilitating and often permanent condition. One promising therapeutic concept is to implant a synthetic scaffold with growth factors through the cribriform plate/scar tissue to induce neuroregeneration. The first step toward this goal is to investigate the optimum conditions (growth factors, extracellular matrix proteins) to boost this regeneration...
August 16, 2023: International Journal of Molecular Sciences
#18
JOURNAL ARTICLE
Rachel Schrader, Nate Posner, Patricia Dorling, Cynthia Senerchia, Yong Chen, Katherine Beaverson, Jerry Seare, Nicolas Garnier, Valery Walker, José Alvir, Matthias Mahn, Valeria Merla, Yiran Zhang, Christina Landis, Ami R Buikema
BACKGROUND: Muscular dystrophies (MDs) comprise a heterogenous group of genetically inherited conditions characterized by progressive muscle weakness and increasing disability. The lack of separate diagnosis codes for Duchenne MD (DMD) and Becker MD, 2 of the most common forms of MD, has limited the conduct of DMD-specific real-world studies. OBJECTIVE: To develop and validate administrative claims-based algorithms for identifying patients with DMD and capturing their nonambulatory and ventilation-dependent status...
September 2023: Journal of Managed Care & Specialty Pharmacy
#19
EDITORIAL
Basile Nicolas Landis, Julien Wen Hsieh, Iordanis Konstantinidis, Eric H Holbrook, Caroline Huart, Eri Mori, Thomas Hummel
No abstract text is available yet for this article.
August 17, 2023: ORL; Journal for Oto-rhino-laryngology and its related Specialties
#20
JOURNAL ARTICLE
Francesco Costa, Carla Daniela Anania, Umberto Agrillo, Assietti Roberto, Bernucci Claudio, Bistazzoni Simona, Bongetta Daniele, Brembilla Carlo, Cappelletto Barbara, Cocciaro Ardico, Costella Giovanni Battista, De Falco Raffaele, De Rosa Andrea, Del Vecchio Carlo, Dobran Mauro, Fiorenza Vito, Garbossa Diego, Guizzardi Giancarlo, Iaccarino Corrado, Irace Claudio, Incerti Michele, Gualtiero Innocenzi, Landi Alessandro, Lastrucci Giancarlo, Maida Giuseppe, Mastrantuoni Ciro, Maugeri Rosario, Meglio Vincenzo, Montemurro Nicola, Nina Pierpaolo, Parlangeli Andrea, Pinna Giovanni, Pretti Pier Federico, Rapanà Armando, Ricci Alessandro, Rispoli Rossella, Romoli Stefano, Per Filippo Sbaffi, Somma Teresa, Tessitore Enrico, Vitali Matteo, Alberto Zerbi, Zona Gianluigi, Andrea Barbanera
Cervical spondylotic myelopathy (CSM) is a progressively growing pathology to afford by a spinal surgeon due to the aging of the population, associated with better treatment management and the best diagnosis and treatment solutions are greatly discussed. Nowadays that scientific literature is progressively increasing to identify the gold standard in diagnosis and treatment can be very challenging. This is particularly evident in spinal surgery with many different indications not only in different countries but also in the same local reality...
June 2023: Neurospine
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
