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Detoxification

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https://www.readbyqxmd.com/read/29667322/bhlh104-confers-tolerance-to-cadmium-stress-in-arabidopsis-thaliana
#1
Xiani Yao, Yuerong Cai, Diqiu Yu, Gang Liang
Cd is a non-essential heavy metal that is toxic to both plants and animals. Here, we reveal that the transcription factor bHLH104 positively regulates Cd tolerance in Arabidopsis thaliana. We found that Fe deficiency-responsive genes were induced by Cd treatment, and that their upregulation was suppressed in bhlh104 loss-of-function mutants but enhanced upon overexpression of bHLH104. Correspondingly, the bhlh104 mutants displayed sensitivity to Cd stress, whereas plants overexpressing bHLH104 exhibited enhanced Cd tolerance...
April 18, 2018: Journal of Integrative Plant Biology
https://www.readbyqxmd.com/read/29666628/you-shall-not-pass-root-vacuoles-as-a-symplastic-checkpoint-for-metal-translocation-to-shoots-and-possible-application-to-grain-nutritional-quality
#2
REVIEW
Felipe K Ricachenevsky, Artur T de Araújo Junior, Janette P Fett, Raul A Sperotto
Plant nutrient uptake is performed mostly by roots, which have to acquire nutrients while avoiding excessive amounts of essential and toxic elements. Apoplastic barriers such as the casparian strip and suberin deposition block free diffusion from the rhizosphere into the xylem, making selective plasma membrane transporters able to control elemental influx into the root symplast, efflux into the xylem and therefore shoot translocation. Additionally, transporters localized to the tonoplast of root cells have been demonstrated to regulate the shoot ionome, and may be important for seed elemental translocation...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29666506/insights-into-aluminum-tolerance-pathways-in-stylosanthes-as-revealed-by-rna-seq-analysis
#3
Caode Jiang, Lusheng Liu, Xiaofeng Li, Rongrong Han, Yunmin Wei, Yongxiong Yu
Stylo has a great potential for Al3+ resistance in acidic soils through secretion of citrate from the roots. To get insight into the molecular mechanisms responsible, transcriptomic changes were investigated in the roots after treatment with T01 (-Al3+ , pH6.0), T02 (-Al3+ , pH4.3) and T03 (50 µM AlCl3 , pH4.3). In total, 83,197 unigenes generated from 130,933 contigs were obtained. Of them, 282, 148 and 816 differentially expressed unigenes (DEGs) were revealed in T01_vs_T02, T02_vs_T03 and T01_vs_T03 comparison, respectively (FDR < 0...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29666456/serotonin-is-an-endogenous-regulator-of-intestinal-cyp1a1-via-ahr
#4
Christopher Manzella, Megha Singhal, Waddah A Alrefai, Seema Saksena, Pradeep K Dudeja, Ravinder K Gill
Aryl hydrocarbon receptor (AhR) is a nuclear receptor that controls xenobiotic detoxification via induction of cytochrome P450 1A1 (CYP1A1) and regulates immune responses in the intestine. Metabolites of L-tryptophan activate AhR, which confers protection against intestinal inflammation. We tested the hypothesis that serotonin (5-HT) is an endogenous activator of AhR in intestinal epithelial cells. Treatment of Caco-2 monolayers with 5-HT induced CYP1A1 mRNA in a time- and concentration-dependent manner and also stimulated CYP1A1 activity...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29666321/glutathione-s-transferase-m1-and-t1-null-genotype-frequency-distribution-among-four-tribal-populations-of-western-india
#5
Prem Chandra Suthar, Pulakes Purkait, Kiran Uttaravalli, B N Sarkar, Rakshit Ameta, Mithun Sikdar
Glutathione S transferase (GST) family is a key contributor in the detoxification mechanism of our body.Deletion of the genes within this family has been reported in the failure of detoxification system, to some extent leading to various types of cancers and other life threatening diseases. The existing data and reports on the association of null genotype of both GSTM1 and GSTT1 genes for various diseases are inconsistent. But knowledge of the polymorphic distributions of genotypes in different populations is important for investigating the risk factors in different epidemiological studies...
March 2018: Journal of Genetics
https://www.readbyqxmd.com/read/29664942/dietary-cyanogen-exposure-and-early-child-neurodevelopment-an-observational-study-from-the-democratic-republic-of-congo
#6
Espérance Kashala-Abotnes, Marie-Thérèse Sombo, Daniel L Okitundu, Marcel Kunyu, Guy Bumoko Makila-Mabe, Thorkild Tylleskär, Alla Sikorskii, Jean-Pierre Banea, Dieudonné Mumba Ngoyi, Désiré Tshala-Katumbay, Michael J Boivin
BACKGROUND: Dietary cyanogen exposure from ingesting bitter (toxic) cassava as a main source of food in sub-Saharan Africa is related to neurological impairments in sub-Saharan Africa. We explored possible association with early child neurodevelopmental outcomes. METHODS: We undertook a cross-sectional neurodevelopmental assessment of 12-48 month-old children using the Mullen Scale of Early Learning (MSEL) and the Gensini Gavito Scale (GGS). We used the Hopkins Symptoms Checklist-10 (HSCL-10) and Goldberg Depression Anxiety Scale (GDAS) to screen for symptoms of maternal depression-anxiety...
2018: PloS One
https://www.readbyqxmd.com/read/29663679/the-role-of-cruciferous-vegetables-and-isothiocyanates-for-lung-cancer-prevention-current-status-challenges-and-future-research-directions
#7
REVIEW
Zhenzhen Zhang, Raymond Bergan, Jackilen Shannon, Christopher G Slatore, Gerd Bobe, Yumie Takata
Lung cancer remains a leading cause of cancer-related deaths in the United States. Although smoking and air pollution exposure are primary risk factors of lung cancer, diet has also been reported to contribute to lung cancer risk. Cruciferous vegetables contain many bioactive compounds that alter the detoxification process of air-borne carcinogenic compounds and, thereby, may decrease lung cancer risk. In our meta-analysis of 31 observational studies, cruciferous vegetable intake was inversely associated with lung cancer risk (summary odds ratio/relative risk = 0...
April 16, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29660465/jageum-jung-improves-2-4-dinitrochlorobenzene-induced-atopic-dermatitis-like-skin-lesions-in-mice-and-suppresses-pro-inflammatory-chemokine-production-by-inhibiting-tnf-%C3%AE-ifn-%C3%AE-induced-stat-1-and-nf%C3%AE%C2%BAb-signaling-in-hacat-cells
#8
Ju-Hye Yang, Hyun Ju Do, Esther Lee, Nam-Hui Yim, Won-Kyung Cho, Kwang-Il Park, Jin Yeul Ma
ETHNOPHARMACOLOGICAL RELEVANCE: Jageum-Jung (JGJ) is an oriental herbal formula comprising five herbs (Melaphis chinensis Bell, Cremastra variabilis Nakai, Knoxia valerianoides Thorel, Euphorbia lathyris L., and Moschus moschiferus L.). It has been used for detoxification and treating cancer and inflammatory diseases in China, Japan, and Korea. However, the mechanism of action of JGJ on keratinocyte inflammatory response is poorly understood. AIM OF THE STUDY: In the present study, we investigated the anti-inflammatory mechanism of JGJ and studied the effects of JGJ on atopic dermatitis-like skin lesions in mice...
April 13, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29660445/development-of-a-new-tool-for-the-long-term-in-vitro-ecotoxicity-testing-of-nanomaterials-using-a-rainbow-trout-cell-line-rtl-w1
#9
L Galbis-Martínez, M L Fernández-Cruz, L Alte, A Valdehita, I Rucandio, J M Navas
The current wide use of manufactured nanomaterials (MNs) is leading to the release of nanoparticles (NPs) to water bodies. Aquatic organisms, including fish, are exposed to low concentrations of NPs for long periods of time being necessary to develop laboratory toxicity tests reflecting realistic conditions. Additionally, today there is a demand of in vitro assays respecting the 3Rs principle. Thus, the main aim of this work was to stablish an in vitro tool for the assessment of long-term NPs ecotoxicity. Considering the key role of liver in detoxification, a rainbow trout liver cell line, RTL-W1, was used...
April 13, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29659911/comparative-bio-efficacy-and-synergism-of-new-generation-polyfluorobenzyl-and-conventional-pyrethroids-against-culex-quinquefasciatus-diptera-culicidae
#10
Manas Sarkar, Ambadas Akulwad, Rajendra Kshirsagar, Siva Muthukrishnan
Intensive exposure to insecticides has resulted in the evolution of insecticide resistance in the mosquitoes. We tested the bio-efficacy of two Culex quinquefasciatus Say (Diptera: Culicidae) laboratory strains differentially bio-responsive to pyrethroids to understand the comparative efficacy of different polyfluorobenzyle and conventional pyrethroid molecules and the role of piperonyl butoxide (PBO) in synergizing these molecules in increased tolerance of mosquitoes to these molecules. We have taken deltamethrin (α-cyano pyrethroid with phenoxybenzyl moiety); permethrin (phenoxybenzyl pyrethroid without an α-cyano group); transfluthrin, dimefluthrin, metofluthrin, and meperfluthrin (polyfluorinated benzyl compounds); and prallethrin (modified cyclopentadienone compound) for this study...
April 12, 2018: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29658695/pdag-bimetallic-nano-alloy-decorated-graphene-a-nanohybrid-with-unprecedented-electrocatalytic-catalytic-and-sensing-activity
#11
Sajad Ahmad Bhat, Nusrat Rashid, Mudasir Ahmad Rather, Sarwar Ahmad Pandit, Ghulam Mohammad Rather, Pravin P Ingole, Mohsin Ahmad Bhat
The recent reports about the promising and tuneable electrocatalytic activity and stability of nanoalloys have stimulated an intense research activity towards the design and synthesis of homogenously alloyed novel bimetallic nano-electrocatalysts. We, herein present a simple one-pot facile wet-chemical approach for the deposition of high quality bimetallic palladium-silver (PdAg) homogenous nanoalloy crystals on reduced graphene oxide (Gr) sheets. Morphological, structural and chemical characterization of the so crafted nanohybrids establishes a homogeneous distribution of 1:1 PdAg nanoalloy crystals supported over reduced graphene oxide (PdAg-Gr)...
April 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29658402/detoxification-process-of-tolaasins-lipodepsipeptides-by-microbacterium-sp-k3-5
#12
Shun Tomita, Masayuki Sue, Akinobu Kajikawa, Shizunobu Igimi, Hirosuke Shinohara, Kenji Yokota
Tolaasins are antimicrobial lipodepsipeptides. Here, we report the tolaasins-detoxifying properties of Microbacterium sp. K3-5 (K3-5). The detoxification of tolaasins by K3-5 was performed by hydrolyzation of cyclic structure of tolaasins depending on the tolaasin-K3-5 cell interaction. Our data suggest that the cyclic structure of tolaasins is critical for its interaction to target cells.
April 15, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29658146/uva-metabolism-and-melanoma-uva-makes-melanoma-hungry-for-metastasis
#13
REVIEW
York Kamenisch, Irina Ivanova, Konstantin Drexler, Mark Berneburg
Ultraviolet (UV) radiation has a plethora of effects on human tissues. In the UV spectrum, wavelengths above 320nm fall into the UVA-range and for these it has been shown that they induce reactive oxygen species (ROS), DNA mutations and are capable to induce melanoma in mice. In addition to this it was recently shown that UVA irradiation and UVA-induced ROS also increase glucose metabolism of melanoma cells. UVA irradiation causes a persistent increase in glucose consumption, accompanied by increased glycolysis, increased lactic acid production and activation of the pentose phosphate pathway...
April 15, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29658041/real-time-monitoring-of-the-trojan-horse-effect-of-silver-nanoparticles-by-using-a-genetically-encoded-fluorescent-cell-sensor
#14
Fang You, Wenqin Tang, Lin-Yue Lanry Yung
Silver nanoparticles (AgNPs) are widely incorporated into commercial products due to their antimicrobial properties. As a consequence, concerns about the adverse effects induced by AgNPs to humans and the environment need to be carefully examined. The existing literature reveals that AgNPs exhibit certain toxic effects, but it remains to be proved whether AgNPs or the ionic silver (Ag+) released from AgNPs are the main toxic species. Here, a genetically encoded fluorescent protein sensor with high affinity to Ag+ was developed...
April 16, 2018: Nanoscale
https://www.readbyqxmd.com/read/29652104/the-influence-of-lead-nanoparticles-on-the-morpho-functional-changes-of-rat-liver-during-the-postexposure-period
#15
Vasyl Aleksiichuk, Sergiy Omelchuk, Liudmyla Sokurenko, Rostyslav Kaminsky, Oleksandr Kovalchuk, Yuri Chaikovsky
Lead as any heavy metals may be found in soil, water, air, and is used in everyday life. Once in the body, it causes toxic effect, making the liver, which is one of the main organs of detoxification, suffer. Recently, the study of the action of not only ionic forms of lead, but also its nanoparticles, has become topical. The study aims at determining changes in the liver of rats and biochemical changes in their blood both at late term of exposure to nanoparticles of lead compounds and in the post-exposure period...
April 13, 2018: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29651749/medium-chain-triglycerides-supplement-therapy-with-a-low-carbohydrate-formula-can-supply-energy-and-enhance-ammonia-detoxification-in-the-hepatocytes-of-patients-with-adult-onset-type-ii-citrullinemia
#16
Kiyoshi Hayasaka, Chikahiko Numakura, Mitsunori Yamakawa, Tetsuo Mitsui, Hisayoshi Watanabe, Hiroaki Haga, Masahide Yazaki, Hiromasa Ohira, Yasuo Ochiai, Toshiyuki Tahara, Tamio Nakahara, Noriyo Yamashiki, Takahiro Nakayama, Takashi Kon, Hiroshi Mitsubuchi, Hiroshi Yoshida
Citrin, encoded by SLC25A13, constitutes the malate-aspartate shuttle, the main NADH-shuttle in the liver. Citrin deficiency causes neonatal intrahepatic cholestasis (NICCD) and adult-onset type II citrullinemia (CTLN2). Citrin deficiency is predicted to impair hepatic glycolysis and de novo lipogenesis, resulting in hepatic energy deficit. Secondary decrease in hepatic argininosuccinate synthetase (ASS1) expression has been considered a cause of hyperammonemia in CTLN2. We previously reported that medium-chain triglyceride (MCT) supplement therapy with a low-carbohydrate formula was effective in CTLN2 to prevent a relapse of hyperammonemic encephalopathy...
April 12, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29651711/baclofen-to-prevent-relapse-in-gamma-hydroxybutyrate-ghb-dependent-patients-a-multicentre-open-label-non-randomized-controlled-trial
#17
Harmen Beurmanjer, Rama M Kamal, Cor A J de Jong, Boukje A G Dijkstra, Arnt F A Schellekens
BACKGROUND: Gamma-hydroxybutyrate (GHB) dependence is associated with a severe, potentially lethal, withdrawal syndrome and relapse rates as high as 60% within 3 months of detoxification. Baclofen has been shown to decrease self-administration of GHB in mice and reduce relapse in a case series of GHB-dependent patients. Controlled studies on the effectiveness of baclofen to prevent relapse in GHB-dependent patients are lacking. AIM: The aim of this study was to assess effectiveness of baclofen in preventing relapse in GHB-dependent patients...
April 12, 2018: CNS Drugs
https://www.readbyqxmd.com/read/29651636/aflatoxin-m-1-detoxification-ability-of-probiotic-lactobacilli-of-indian-origin-in-in-vitro-digestion-model
#18
Rohit Panwar, Narendra Kumar, Vipul Kashyap, Chand Ram, Rajeev Kapila
Aflatoxin M1 (AFM1 ) is known to be a potent carcinogen and continues to pose a public health concern through the consumption of contaminated dairy foods. It is anticipated that consumption of lactic acid bacteria capable of binding aflatoxins can reduce the risk of AFM1 on human health to a certain extent. Seldom reports have hinted the possibility of using lactic acid bacteria for the biological detoxification of AFM1 . Hence, the present study was conducted to assess the ability of selected probiotic Lactobacillus strains for their AFM1 binding ability in PBS and to reduce its bioaccessibility in artificially contaminated skim milk using an in vitro digestion model...
April 12, 2018: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29651254/antioxidant-role-of-pcgstd1-in-fenpropathrin-resistant-population-of-the-citrus-red-mite-panonychus-citri-mcgregor
#19
Chong-Yu Liao, Ying-Cai Feng, Gang Li, Xiao-Min Shen, Shi-Huo Liu, Wei Dou, Jin-Jun Wang
The citrus red mite, Panonychus citri , a major citrus pest distributed worldwide, has evolved severe resistance to various classes of chemical acaricides/insecticides including pyrethroids. It is well known that the resistance to pyrethroids is mainly caused by point mutations of voltage-gated sodium channel gene in a wide range of pests. However, increasing number of evidences support that pyrethroids resistance might also be resulted from the integrated mechanisms including metabolic mechanisms. In this study, firstly, comparative analysis of RNA-seq data showed that multiple detoxification genes, including a GSTs gene PcGSTd1 , were up-regulated in a fenpropathrin-resistant population compared with the susceptible strain (SS)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29649094/methadone-maintenance-treatment-a-15-year-retrospective-study-in-split-dalmatia-county-croatia
#20
Davorka Sutlovic, Zeljko Kljucevic, Livia Sliskovic, Helena Susnjar, Ivo Viskovic, Marija Definis-Gojanovic
BACKGROUND: The aim of this retrospective study is to use existing epidemiological data on patients in methadone maintenance treatment in Split Dalmatia County from 2001 to 2015 in order to evaluate the substitution treatment system and policy of opiate addicts treatment, the epidemiological trend, and risk of overdose mortality. In addition, we would like to highlight the problem of poor control of methadone therapy, and thus the possibility of selling methadone. The result is a greater number of deaths caused by methadone in people who were not in methadone therapy...
April 11, 2018: Therapeutic Drug Monitoring
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