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https://www.readbyqxmd.com/read/28434177/eating-disorders-and-food-addiction-in-men-with-heroin-use-disorder-a-controlled-study
#1
Fatih Canan, Servet Karaca, Suna Sogucak, Omer Gecici, Murat Kuloglu
PURPOSE: We aimed to determine the prevalence estimates of binge eating disorder, bulimia nervosa, anorexia nervosa, and food addiction in men with heroin use disorder and a matched sample of control participants. METHODS: A group of 100 men with heroin use disorder, consecutively admitted to a detoxification and therapy unit, were screened for DSM-5 eating disorders, along with a group of 100 male controls of similar age, education, and body mass index. The Yale Food Addiction Scale (YFAS), the Barratt Impulsivity Scale-version 11, and the Eating Attitudes Test were used for data collection...
April 22, 2017: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/28432996/toxicological-effects-of-phenol-on-four-marine-microalgae
#2
Weiyan Duan, Fanping Meng, Yufei Lin, Guoshan Wang
The toxic effects of phenol on four marine microalgae (Dunaliella salina, Platymonas subcordiformis, Phaeodactylum tricornutum Bohlin, and Skeletonema costatum) were evaluated. The 96h EC50 values were 72.29, 92.97, 27.32, and 27.32mgL(-1), respectively, which were lower than those values of freshwater microalgae reported in the literature. During a 96-h exposure to a sub-lethal concentration of phenol (1/2 96h EC50) with green alga (D. salina) and diatom (S. costatum), reactive oxygen species (ROS) accumulation, and chlorophyll a (Chl a) content decrease were simultaneously observed in diatom cells after 48h treatment...
April 13, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28432992/bioaccumulation-kinetics-of-copper-in-ruditapes-philippinarum-exposed-to-increasing-continuous-and-pulsed-exposure-implications-for-growth
#3
Lígia M B M Santana, Julián Blasco, Denis M S Abessa, Olivia Campana
Metal bioaccumulation and toxicity to aquatic organisms depends on factors such as magnitude, duration and frequency of the exposure. The type of the exposure affects the toxicokinetic processes in the organisms. In this study, we carried out 30-day toxicity tests on juveniles of Ruditapes philippinarum exposed to increasing, continuous and pulsed exposure. Organisms were exposed to copper-spiked sediments followed by a 10-day recovery period. We assessed the interaction between the kinetics of subcellular copper partitioning and the growth response...
April 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28432686/high-level-of-reduced-glutathione-contributes-to-detoxification-of-lipid-peroxide-derived-reactive-carbonyl-species-in-transgenic-arabidopsis-overexpressing-glutathione-reductase-under-aluminum-stress
#4
Lina Yin, Jun'ichi Mano, Kiyoshi Tanaka, Shiwen Wang, Meijuan Zhang, Xiping Deng, Suiqi Zhang
Lipid peroxide-derived reactive carbonyl species (RCS), generated downstream of reactive oxygen species (ROS), are critical damage-inducing species in plant aluminum (Al) toxicity. In mammals, RCS are scavenged primarily by glutathione (GSH), but in plant Al stress, contribution of GSH to RCS detoxification has not been evaluated. In this study, Arabidopsis plants overexpressing the gene AtGR1 (accession code At3g24170), encoding glutathione reductase (GR), were generated, and their performance under Al stress was examined...
April 21, 2017: Physiologia Plantarum
https://www.readbyqxmd.com/read/28431961/ionizing-radiation-induces-long-term-senescence-in-endothelial-cells-through-mitochondrial-respiratory-complex-ii-dysfunction-and-superoxide-generation
#5
Audrey Lafargue, Charlotte Degorre, Isabelle Corre, Marie-Clotilde Alves-Guerra, Marie-Hélène Gaugler, François Vallette, Claire Pecqueur, François Paris
Ionizing radiation causes oxidative stress, leading to acute and late cellular responses. We previously demonstrated that irradiation of non-proliferating endothelial cells, as observed in normal tissues, induces early apoptosis, which can be inhibited by pretreatment with Sphingosine-1-Phosphate. We now propose to better characterize the long-term radiation response of endothelial cells by studying the molecular pathways associated with senescence and its link with acute apoptosis. First, senescence was validated in irradiated quiescent microvascular HMVEC-L in a dose- and time-dependent manner by SA β-galactosidase staining, p16(Ink4a) and p21(Waf1) expression, pro-inflammatory IL-8 secretion and DNA damage response activation...
April 18, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28431562/effects-of-the-common-polymorphism-in-the-human-aldehyde-dehydrogenase-2-aldh2-gene-on-the-lung
#6
Aoi Kuroda, Ahmed E Hegab, Gao Jingtao, Shuji Yamashita, Nobuyuki Hizawa, Tohru Sakamoto, Hideyasu Yamada, Satoshi Suzuki, Makoto Ishii, Ho Namkoong, Takanori Asakura, Mari Ozaki, Hiroyuki Yasuda, Junko Hamamoto, Shizuko Kagawa, Kenzo Soejima, Tomoko Betsuyaku
BACKGROUND: Aldehyde dehydrogenases (ALDHs) play a major role in detoxification of aldehydes. High expression of ALDHs is a marker for stem cells of many organs including the lungs. A common polymorphism in ALDH2 gene (ALDH2*2) results in inactivation of the enzyme and is associated with alcohol flushing syndrome and increased risk for cardiovascular and Alzheimer's diseases and some cancers. The effect of this ALDH2 polymorphism on the lung and its stem cells has not been thoroughly examined...
April 21, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28430929/promoter-polymorphism-rs886205-genotype-interacts-with-dna-methylation-of-the-aldh2-regulatory-region-in-alcohol-dependence
#7
Hansi Pathak, Helge Frieling, Stefan Bleich, Alexander Glahn, Annemarie Heberlein, Mani Haschemi Nassab, Thomas Hillemacher, Alexandra Burkert, Mathias Rhein
Aims: Aldehyde dehydrogenase 2 (ALDH2) protects cells from ethanol toxicity by metabolizing acetaldehyde. We studied the single nucleotide polymorphism (SNP) rs886205s located between a negative and a positive regulating promoter element in the ALDH2 gene. The negative regulatory region was already associated with differential DNA methylation in the two allele variations of rs886205 SNP. Another CpG island, in the positive regulatory region of the ALDH2 promoter, extends through the SNP rs886205 and a nuclear receptor response element...
May 1, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28430654/alpha-ketoglutarate-suppresses-the-nf-%C3%AE%C2%BAb-mediated-inflammatory-pathway-and-enhances-the-pxr-regulated-detoxification-pathway
#8
Liuqin He, Huan Li, Niu Huang, Xihong Zhou, Junquan Tian, Tiejun Li, Jing Wu, Yanan Tian, Yulong Yin, Kang Yao
Alpha-ketoglutarate (AKG) is a critical nutritional factor in the maintenance of intestinal homeostasis. However, the relative mechanism of AKG has not been well understood. It was recently shown that the interaction between nuclear factor kappa B (NF-κB)-mediated inflammatory pathway and pregnane X receptor (PXR)-regulated detoxification pathway is a check and balance mechanism for keeping the homeostatic state of the intestine, preventing the onset of intestinal inflammation which may lead to cancer. In the current study we used lipopolysaccharide (LPS)-challenged piglet and intestinal porcine epithelial cells-J2 models to investigate the effects of dietary AKG supplementation on the intestinal immune system and PXR regulated target expression...
April 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28428950/endogenous-and-exogenous-kdpf-peptide-increases-susceptibility-of-mycobacterium-bovis-bcg-to-nitrosative-stress-and-reduces-intramacrophage-replication
#9
Mariana Rosas Olvera, Eric Vivès, Virginie Molle, Anne-Béatrice Blanc-Potard, Laila Gannoun-Zaki
Emerging antibiotic resistance in pathogenic bacteria like Mycobacterium sp., poses a threat to human health and therefore calls for the development of novel antibacterial strategies. We have recently discovered that bacterial membrane peptides, such as KdpF, possess anti-virulence properties when overproduced in pathogenic bacterial species. Overproduction of the KdpF peptide in Mycobacterium bovis BCG decreased bacterial replication within macrophages, without presenting antibacterial activity. We propose that KdpF functions as a regulatory molecule and interferes with bacterial virulence, potentially through interaction with the PDIM transporter MmpL7...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28428286/a-genetic-analysis-of-the-caenorhabditis-elegans-detoxification-response
#10
Tetsunari Fukushige, Harold E Smith, Johji Miwa, Michael W Krause, John A Hanover
Oxidative damage contributes to human diseases of aging including diabetes, cancer, and cardiovascular disorders. Reactive oxygen species resulting from xenobiotic and endogenous metabolites are sensed by a poorly understood process, triggering a cascade of regulatory factors and leading to the activation of the transcription factor Nrf2 (SKN-1 in Caenorhabditis elegans). Nrf2/SKN-1 activation promotes the induction of the Phase II detoxification system that serves to limit oxidative stress. We have extended a previous C...
April 19, 2017: Genetics
https://www.readbyqxmd.com/read/28428138/pregnane-x-receptor-regulates-the-ahr-cyp1a1-pathway-and-protects-liver-cells-from-benzo-%C3%AE-pyrene-induced-dna-damage
#11
Hongmei Cui, Xinsheng Gu, Jingshu Chen, Ying Xie, Sui Ke, Jing Wu, Andrei Golovko, Benjamin Morpurgo, Chunhong Yan, Timothy D Phillips, Wen Xie, Jianyuan Luo, Zhijun Zhou, Yanan Tian
Pregnane X receptor (PXR) plays an important role in protecting cells from mutagenic DNA damages induced by endogenous and exogenous toxicants. This protective function is often attributed to the PXR-regulated metabolic detoxification. Here we report a novel potential mechanism that PXR reduces benzo-[α]-pyrene(BaP)-induced DNA damage through inhibiting the transcriptional activity of aryl hydrocarbon receptor (AhR) which plays a pivotal role in the bioactivation of BaP. We have utilized three well-characterized cell lines, i...
April 17, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28428060/effects-of-chronic-ammonia-exposure-on-ammonia-metabolism-and-excretion-in-marine-medaka-oryzias-melastigma
#12
Na Gao, Limei Zhu, Zhiqiang Guo, Meisheng Yi, Li Zhang
Ammonia is highly toxic to aquatic organisms, but whether ammonia excretion or ammonia metabolism to less toxic compounds is the major strategy for detoxification in marine fish against chronic ammonia exposure is unclear to date. In this study, we investigated the metabolism and excretion of ammonia in marine medaka Oryzias melastigma during chronic ammonia exposure. The fish were exposed to 0, 0.1, 0.3, 0.6, and 1.1 mmol l(-1) NH4Cl spiked seawater for 8 weeks. Exposure of 0.3-1.1 mmol l(-1) NH4Cl had deleterious effects on the fish, including significant reductions in growth, feed intake, and total protein content...
April 17, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28427774/phosphorus-effects-on-radial-oxygen-loss-root-porosity-and-iron-plaque-in-two-mangrove-seedlings-under-cadmium-stress
#13
Minyue Dai, Jingchun Liu, Wenwen Liu, Haoliang Lu, Hui Jia, Hualong Hong, Chongling Yan
Phosphorus is an indispensable element for plants, but its role in alleviating the cadmium toxicity of mangrove seedlings is poorly documented. In this study, mangrove seedlings were grown in hydroponics and exposed to various Cd and P treatments. Data suggested that the inhibitory effect of Cd on the rate of radial oxygen loss and root porosity was alleviated by P. A. marina had a higher rate of ROL and POR, indicating that it had a stronger adaptability to anaerobic environment. K. obovata induced a higher Fe concentration in iron plaque under co-application of Cd and P, which may relate to higher biomass...
April 17, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28427494/characterization-and-expression-analysis-of-peroxiredoxin-genes-in-nnk-induced-v79-cells
#14
Gui Qin Shi, Wen Shan Zhou, Meng Li, Fei Ren, Ya Wei Han
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a potent and prevalent nitrosamine procarcinogen found in cigarette smoke. The aim of this work is to study alterations in peroxiredoxin (Prx) expression induced by NNK during carcinogenesis. Characterization of Prx genes from hamster was performed using bioinformatics. V79 cells were induced with different concentrations of NNK (0.1-0.4 mg/mL), and the expression levels of six Prx genes (Prx1-Prx6) were measured by qRT-PCR 24 h following NNK treatment...
March 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28427347/comparative-transcriptomics-of-mountain-pine-beetle-pheromone-biosynthetic-tissues-and-functional-analysis-of-cyp6de3
#15
J A Nadeau, J Petereit, R L Tillett, K Jung, M Fotoohi, M MacLean, S Young, K Schlauch, G J Blomquist, C Tittiger
BACKGROUND: The mountain pine beetle (MPB, Dendroctonus ponderosae Hopkins) is a highly destructive pest of pine forests in western North America. During flight to a new host tree and initiation of feeding, mountain pine beetles release aggregation pheromones. The biosynthetic pathways of these pheromones are sex-specific and localized in the midgut and fat body, but the enzymes involved have not all been identified or characterized. RESULTS: We used a comparative RNA-Seq analysis between fed and unfed male and female MPB midguts and fat bodies to identify candidate genes involved in pheromone biosynthesis...
April 20, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28426746/low-levels-of-cd-induce-persisting-epigenetic-modifications-and-acclimation-mechanisms-in-the-earthworm-lumbricus-terrestris
#16
Maja Šrut, Victoria Drechsel, Martina Höckner
Toxic effects of cadmium (Cd), a common soil pollutant, are still not very well understood, particularly in regard to its epigenetic impact. Therefore, the aim of this study was to assess DNA methylation changes and their persistence in the earthworm Lumbricus terrestris upon chronic low dose Cd exposure using methylation sensitive amplification polymorphism (MSAP). Moreover, the biomarker response and fitness of the earthworms, as well as the expression of detoxification-related genes (metallothionein (MT) and phytochelatin synthase (PCS)) was evaluated...
2017: PloS One
https://www.readbyqxmd.com/read/28425450/toxicological-and-biochemical-basis-of-synergism-between-the-entomopathogenic-fungus-lecanicillium-muscarium-and-the-insecticide-matrine-against-bemisia-tabaci-gennadius
#17
Shaukat Ali, Can Zhang, Zeqing Wang, Xing-Min Wang, Jian-Hui Wu, Andrew G S Cuthbertson, Zhenfang Shao, Bao-Li Qiu
The sweetpotato whitefly Bemisia tabaci (Gennadius) was challenged with different combinations of matrine (insecticide) and Lecanicillium muscarium (entomopathogenic fungus). Our results revealed a synergistic relationship between matrine and L. muscarium on mortality and enzyme activities of B. tabaci. To illustrate the biochemical mechanisms involved in detoxification and immune responses of B. tabaci against both control agents, activities of different detoxifying and antioxidant enzymes were quantified...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28425127/manipulation-of-glyoxalase-pathway-confers-tolerance-to-multiple-stresses-in-rice
#18
Brijesh K Gupta, Khirod K Sahoo, Ajit Ghosh, Amit K Tripathi, Khalid Anwar, Priyanka Das, Anil K Singh, Ashwani Pareek, Sudhir K Sopory, Sneh L Singla-Pareek
Crop plants face a multitude of diverse abiotic and biotic stresses in the farmers' fields. Although there now exists a considerable knowledge of the underlying mechanisms of response to individual stresses, the cross-talk between response pathways to various abiotic and biotic stresses remains enigmatic. Here, we investigated if the cytotoxic metabolite methylglyoxal (MG), excess of which is generated as a common consequence of many abiotic and biotic stresses, may serve as a key molecule linking responses to diverse stresses...
April 20, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28424666/napa-mediates-a-redox-regulation-of-the-antioxidant-response-carbon-utilization-and-development-in-aspergillus-nidulans
#19
Ariann E Mendoza-Martínez, Fernando Lara-Rojas, Olivia Sánchez, Jesús Aguirre
The redox-regulated transcription factors (TFs) of the bZIP AP1 family, such as yeast Yap1 and fission yeast Pap1, are activated by peroxiredoxin proteins (Prxs) to regulate the antioxidant response. Previously, Aspergillus nidulans mutants lacking the Yap1 ortholog NapA have been characterized as sensitive to H2O2 and menadione. Here we study NapA roles in relation to TFs SrrA and AtfA, also involved in oxidant detoxification, showing that these TFs play different roles in oxidative stress resistance, catalase gene regulation and development, during A...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28421616/the-validity-of-the-montgomery-asberg-depression-rating-scale-in-an-inpatient-sample-with-alcohol-dependence
#20
Breanne Hobden, Melanie L Schwandt, Mariko Carey, Mary R Lee, Mehdi Farokhnia, Sofia Bouhlal, Christopher Oldmeadow, Lorenzo Leggio
BACKGROUND: The Montgomery-Asberg Depression Rating Scale (MADRS) is commonly used to examine depressive symptoms in clinical settings, including facilities treating patients for alcohol addiction. No studies have examined the validity of the MADRS compared to an established clinical diagnostic tool of depression in this population. This study aimed to examine: 1) the validity of the MADRS compared to a clinical diagnosis of a depressive disorder (using the Structured Clinical Interview for DSM-IV (SCID)) in patients seeking treatment for alcohol dependence (AD); 2) whether the validity of the MADRS differs by type of SCID-based diagnosis of depression; and 3) which items contribute to the optimal predictive model of the MADRS compared to a SCID diagnosis of a depressive disorder...
April 19, 2017: Alcoholism, Clinical and Experimental Research
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