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Zika infections and complications

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https://www.readbyqxmd.com/read/29773562/neuroimaging-findings-of-zika-virus-associated-neurologic-complications-in-adults
#1
REVIEW
L C Hygino da Cruz, O J M Nascimento, F P P L Lopes, I R F da Silva
When the first suspected cases of neurologic disorders associated with the Zika virus were noticed in Brazil in late 2015, several studies had been conducted to understand the pathophysiology of the disease and its associated complications. In addition to its well-established association with microcephaly in neonates, the Zika virus infection has also been suggested to trigger other severe neurologic complications in adults, such as Guillain-Barré syndrome, radiculomyelitis, and meningoencephalitis. Hence, the Zika virus should be deemed a global threat that can cause devastating neurologic complications among individuals in all age ranges...
May 17, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29768624/analysis-of-the-immunological-biomarker-profile-during-acute-zika-virus-infection-reveals-the-overexpression-of-cxcl10-a-chemokine-linked-to-neuronal-damage
#2
Felipe Gomes Naveca, Gemilson Soares Pontes, Aileen Yu-Hen Chang, George Allan Villarouco da Silva, Valdinete Alves do Nascimento, Dana Cristina da Silva Monteiro, Marineide Souza da Silva, Lígia Fernandes Abdalla, João Hugo Abdalla Santos, Tatiana Amaral Pires de Almeida, Matilde Del Carmen Contreras Mejía, Tirza Gabrielle Ramos de Mesquita, Helia Valeria de Souza Encarnação, Matheus de Souza Gomes, Laurence Rodrigues Amaral, Ana Carolina Campi-Azevedo, Jordana Graziela Coelho-Dos-Reis, Lis Ribeiro do Vale Antonelli, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Rajendranath Ramasawmy
BACKGROUND: Infection with Zika virus (ZIKV) manifests in a broad spectrum of disease ranging from mild illness to severe neurological complications and little is known about Zika immunopathogenesis. OBJECTIVES: To define the immunologic biomarkers that correlate with acute ZIKV infection. METHODS: We characterized the levels of circulating cytokines, chemokines, and growth factors in 54 infected patients of both genders at five different time points after symptom onset using microbeads multiplex immunoassay; comparison to 100 age-matched controls was performed for statistical analysis and data mining...
May 14, 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29768530/ns1-codon-usage-adaptation-to-humans-in-pandemic-zika-virus
#3
Caio César de Melo Freire, Giuseppe Palmisano, Carla T Braconi, Fernanda R Cugola, Fabiele B Russo, Patricia Cb Beltrão-Braga, Atila Iamarino, Daniel Ferreira de Lima Neto, Amadou Alpha Sall, Livia Rosa-Fernandes, Martin R Larsen, Paolo Marinho de Andrade Zanotto
BACKGROUND: Zika virus (ZIKV) was recognised as a zoonotic pathogen in Africa and southeastern Asia. Human infections were infrequently reported until 2007, when the first known epidemic occurred in Micronesia. After 2013, the Asian lineage of ZIKV spread along the Pacific Islands and Americas, causing severe outbreaks with millions of human infections. The recent human infections of ZIKV were also associated with severe complications, such as an increase in cases of Guillain-Barre syndrome and the emergence of congenital Zika syndrome...
May 10, 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29751526/molecular-responses-to-the-zika-virus-in-mosquitoes
#4
REVIEW
Catalina Alfonso-Parra, Frank W Avila
The Zika virus (ZIKV), originally discovered in 1947, did not become a major concern until the virus swept across the Pacific and into the Americas in the last decade, bringing with it news of neurological complications and birth defects in ZIKV affected areas. This prompted researchers to dissect the molecular interactions between ZIKV and the mosquito vector in an attempt to better understand not only the changes that occur upon infection, but to also identify molecules that may potentially enhance or suppress a mosquito’s ability to become infected and/or transmit the virus...
May 3, 2018: Pathogens
https://www.readbyqxmd.com/read/29738748/femur-sparing-pattern-of-abnormal-fetal-growth-in-pregnant-women-from-new-york-city-after-maternal-zika-virus-infection
#5
Christie L Walker, Audrey A Merriam, Eric O Ohuma, Manjiri K Dighe, Michael Gale, Lakshmi Rajagopal, Aris T Papageorghiou, Cynthia Gyamfi-Bannerman, Kristina M Adams Waldorf
BACKGROUND: Zika virus (ZIKV) is a mosquito-transmitted flavivirus, which can induce fetal brain injury and growth restriction following maternal infection during pregnancy. Prenatal diagnosis of ZIKV-associated fetal injury in the absence of microcephaly is challenging due to an incomplete understanding of how maternal ZIKV infection affects fetal growth and the use of different sonographic reference standards around the world. We hypothesized that skeletal growth is unaffected by ZIKV infection and that the femur length can represent an internal standard to detect growth deceleration of the fetal head and/or abdomen by ultrasound...
May 5, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29720077/australian-paediatric-surveillance-unit-annual-report-2016
#6
Marie Deverell, Amy Phu, Yvonne Zurynski, Elizabeth Elliott
This report summarises the cases reported to the Australian Paediatric Surveillance Unit (APSU) of rare infectious diseases or rare complications of more common infectious diseases in children. During the calendar year 2016, there were approximately 1500 paediatricians reporting to the APSU and the monthly report card return rate was 90%. APSU continued to provide unique national data on the perinatal exposure to HIV, congenital rubella, congenital cytomegalovirus, neonatal and infant herpes simplex virus, and congenital and neonatal varicella...
September 1, 2017: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/29712653/direct-activation-of-adenosine-monophosphate-activated-protein-kinase-ampk-by-pf-06409577-inhibits-flavivirus-infection-through-modification-of-host-cell-lipid-metabolism
#7
Nereida Jiménez de Oya, Ana-Belén Blázquez, Josefina Casas, Juan-Carlos Saiz, Miguel A Martín Acebes
Mosquito-borne flaviviruses are a group of RNA viruses that constitute global threats for human and animal health. Replication of these pathogens is strictly dependent on cellular lipid metabolism. We have evaluated the effect of the pharmacological activation of Adenosine Monophosphate-activated Protein Kinase (AMPK), a master regulator of lipid metabolism, on the infection of three medically relevant flaviviruses: West Nile virus (WNV), Zika virus (ZIKV) and dengue virus (DENV). WNV is responsible for recurrent outbreaks of meningitis and encephalitis affecting humans and horses worldwide...
April 30, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29696139/a-machine-learning-application-based-in-random-forest-for-integrating-mass-spectrometry-based-metabolomic-data-a-simple-screening-method-for-patients-with-zika-virus
#8
Carlos Fernando Odir Rodrigues Melo, Luiz Claudio Navarro, Diogo Noin de Oliveira, Tatiane Melina Guerreiro, Estela de Oliveira Lima, Jeany Delafiori, Mohamed Ziad Dabaja, Marta da Silva Ribeiro, Maico de Menezes, Rafael Gustavo Martins Rodrigues, Karen Noda Morishita, Cibele Zanardi Esteves, Aline Lopes Lucas de Amorim, Caroline Tiemi Aoyagui, Pierina Lorencini Parise, Guilherme Paier Milanez, Gabriela Mansano do Nascimento, André Ricardo Ribas Freitas, Rodrigo Angerami, Fábio Trindade Maranhão Costa, Clarice Weis Arns, Mariangela Ribeiro Resende, Eliana Amaral, Renato Passini Junior, Carolina C Ribeiro-do-Valle, Helaine Milanez, Maria Luiza Moretti, Jose Luiz Proenca-Modena, Sandra Avila, Anderson Rocha, Rodrigo Ramos Catharino
Recent Zika outbreaks in South America, accompanied by unexpectedly severe clinical complications have brought much interest in fast and reliable screening methods for ZIKV (Zika virus) identification. Reverse-transcriptase polymerase chain reaction (RT-PCR) is currently the method of choice to detect ZIKV in biological samples. This approach, nonetheless, demands a considerable amount of time and resources such as kits and reagents that, in endemic areas, may result in a substantial financial burden over affected individuals and health services veering away from RT-PCR analysis...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29695953/autoimmune-neurological-conditions-associated-with-zika-virus-infection
#9
REVIEW
Yeny Acosta-Ampudia, Diana M Monsalve, Luis F Castillo-Medina, Yhojan Rodríguez, Yovana Pacheco, Susan Halstead, Hugh J Willison, Juan-Manuel Anaya, Carolina Ramírez-Santana
Zika virus (ZIKV) is an emerging flavivirus rapidly spreading throughout the tropical Americas. Aedes mosquitoes is the principal way of transmission of the virus to humans. ZIKV can be spread by transplacental, perinatal, and body fluids. ZIKV infection is often asymptomatic and those with symptoms present minor illness after 3 to 12 days of incubation, characterized by a mild and self-limiting disease with low-grade fever, conjunctivitis, widespread pruritic maculopapular rash, arthralgia and myalgia. ZIKV has been linked to a number of central and peripheral nervous system injuries such as Guillain-Barré syndrome (GBS), transverse myelitis (TM), meningoencephalitis, ophthalmological manifestations, and other neurological complications...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29691387/fetal-demise-and-failed-antibody-therapy-during-zika-virus-infection-of-pregnant-macaques
#10
Diogo M Magnani, Thomas F Rogers, Nicholas J Maness, Nathan D Grubaugh, Nathan Beutler, Varian K Bailey, Lucas Gonzalez-Nieto, Martin J Gutman, Núria Pedreño-Lopez, Jaclyn M Kwal, Michael J Ricciardi, Tereance A Myers, Justin G Julander, Rudolf P Bohm, Margaret H Gilbert, Faith Schiro, Pyone P Aye, Robert V Blair, Mauricio A Martins, Kathrine P Falkenstein, Amitinder Kaur, Christine L Curry, Esper G Kallas, Ronald C Desrosiers, Pascal J Goldschmidt-Clermont, Stephen S Whitehead, Kristian G Andersen, Myrna C Bonaldo, Andrew A Lackner, Antonito T Panganiban, Dennis R Burton, David I Watkins
Zika virus (ZIKV) infection of pregnant women is associated with pathologic complications of fetal development. Here, we infect pregnant rhesus macaques (Macaca mulatta) with a minimally passaged ZIKV isolate from Rio de Janeiro, where a high rate of fetal development complications was observed. The infection of pregnant macaques with this virus results in maternal viremia, virus crossing into the amniotic fluid (AF), and in utero fetal deaths. We also treated three additional ZIKV-infected pregnant macaques with a cocktail of ZIKV-neutralizing human monoclonal antibodies (nmAbs) at peak viremia...
April 24, 2018: Nature Communications
https://www.readbyqxmd.com/read/29668332/neurological-complications-of-zika-virus-infection
#11
Francisco Javier Carod-Artal
Zika virus (ZIKV) disease is a vector-borne infectious disease transmitted by Aedes mosquitoes. Recently, ZIKV has caused outbreaks in most American countries. Areas covered: Publications about neurological complications of ZIKV infection retrieved from pubmed searchers were reviewed, and reference lists and relevant articles from review articles were also examined. Vertical/intrauterine transmission leads to congenital infection and causes microcephaly and congenital ZIKV syndrome. ZIKV preferentially infects human neural progenitor cells and triggers cell apoptosis...
May 2018: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29623081/a-new-in-vivo-model-to-study-protective-immunity-to-zika-virus-infection-in-mice-with-intact-type-i-interferon-signaling
#12
Loulieta Nazerai, Amalie Skak Schøller, Peter Overbeck Sharma Rasmussen, Søren Buus, Anette Stryhn, Jan Pravsgaard Christensen, Allan Randrup Thomsen
The association between recent Zika virus (ZIKV) infection and neurological complications, microcephaly in the fetus, and Guillain-Barré syndrome in adults underscores the necessity for a protective vaccine. Rational vaccine development requires an in-depth understanding of the mechanisms which could protect against infection with this virus. However, so far, such an analysis has been hampered by the absence of a suitable small animal model. Unlike the situation in humans, ZIKV only replicates effectively in the peripheral organs of mice, if type I IFN signaling is interrupted...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29621184/the-flavonoid-isoquercitrin-precludes-initiation-of-zika-virus-infection-in-human-cells
#13
Arnaud Gaudry, Sandra Bos, Wildriss Viranaicken, Marjolaine Roche, Pascale Krejbich-Trotot, Gilles Gadea, Philippe Desprès, Chaker El-Kalamouni
The medical importance of Zika virus (ZIKV) was fully highlighted during the recent epidemics in South Pacific islands and Americas due to ZIKV association with severe damage to fetal brain development and neurological complications in adult patients. A worldwide research effort has been undertaken to identify effective compounds to prevent or treat ZIKV infection. Fruits and vegetables may be sources of compounds with medicinal properties. Flavonoids are one class of plant compounds that emerge as promising antiviral molecules against ZIKV...
April 5, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29618586/zika-virus-infection-in-the-returning-traveller-what-every-neurologist-should-know
#14
REVIEW
Sonja Emily Leonhard, Suzannah Lant, Bart C Jacobs, Annelies Wilder-Smith, Maria Lucia Brito Ferreira, Tom Solomon, Hugh John Willison
Zika virus has been associated with a wide range of neurological complications. Neurologists in areas without current active transmission of the virus may be confronted with Zika-associated neurological disease, as a large number of returning travellers with Zika virus infection have been reported and the virus continues to spread to previously unaffected regions. This review provides an overview of Zika virus-associated neurological disease and aims to support neurologists who may encounter patients returning from endemic areas...
April 4, 2018: Practical Neurology
https://www.readbyqxmd.com/read/29617849/mosquito-saliva-the-hope-for-a-universal-arbovirus-vaccine
#15
Jessica E Manning, David M Morens, Shaden Kamhawi, Jesus G Valenzuela, Matthew Memoli
Arthropod-borne viruses (arboviruses) are taxonomically diverse causes of significant morbidity and mortality. In recent decades, important mosquito-borne viruses such as West Nile, chikungunya, dengue, and Zika have re-emerged and spread widely, in some cases pandemically, to cause serious public health emergencies. There are no licensed vaccines against most of these viruses, and vaccine development and use has been complicated by the number of different viruses to protect against, by subtype and strain variation, and by the inability to predict when and where outbreaks will occur...
March 29, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29617816/immunization-with-a-novel-human-type-5-adenovirus-vectored-vaccine-expressing-the-premembrane-and-envelope-proteins-of-zika-virus-provides-consistent-and-sterilizing-protection-in-multiple-immunocompetent-and-immunocompromised-animal-models
#16
Qiang Guo, Jasper Fuk-Woo Chan, Vincent Kwok-Man Poon, Shipo Wu, Chris Chung-Sing Chan, Lihua Hou, Cyril Chik-Yan Yip, Changpeng Ren, Jian-Piao Cai, Mengsu Zhao, Anna Jinxia Zhang, Xiaohong Song, Kwok-Hung Chan, Busen Wang, Kin-Hang Kok, Yanbo Wen, Kwok-Yung Yuen, Wei Chen
Background: Zika virus (ZIKV) infection may be associated with severe complications and disseminated via both vector-borne and non-vector-borne routes. Adenovirus-vectored vaccines represent a favorable controlling measure for the ZIKV epidemic as they have been shown to be safe, immunogenic, and rapidly generable for other emerging viral infections. Evaluations of two previously reported adenovirus-vectored ZIKV vaccines were performed using non-lethal animal models and/or non-epidemic ZIKV strain...
March 29, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29615676/silent-infection-of-human-dendritic-cells-by-african-and-asian-strains-of-zika-virus
#17
Nathalie J Vielle, Beatrice Zumkehr, Obdulio García-Nicolás, Fabian Blank, Miloš Stojanov, Didier Musso, David Baud, Artur Summerfield, Marco P Alves
While Zika virus (ZIKV) circulated for decades (African lineage strains) without report of outbreaks and severe complications, its emergence in French Polynesia and subsequently in the Americas (Asian lineage strains) was associated with description of severe neurological defects in newborns/neonates and adults. With the aim to identify virus lineage-dependent factors, we compared cell susceptibility, virus replication, cell death and innate immune responses following infection with two African and three contemporary Asian lineage strains of ZIKV...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29600283/zika-virus-infection-preferentially-counterbalances-human-peripheral-monocyte-and-or-nk-cell-activity
#18
Fok-Moon Lum, David Lee, Tze-Kwang Chua, Jeslin J L Tan, Cheryl Y P Lee, Xuan Liu, Yongxiang Fang, Bernett Lee, Wearn-Xin Yee, Natasha Y Rickett, Po-Ying Chia, Vanessa Lim, Yee-Sin Leo, David A Matthews, Julian A Hiscox, Lisa F P Ng
Zika virus (ZIKV) has reemerged in the population and caused unprecedented global outbreaks. Here, the transcriptomic consequences of ZIKV infection were studied systematically first in human peripheral blood CD14+ monocytes and monocyte-derived macrophages with high-density RNA sequencing. Analyses of the ZIKV genome revealed that the virus underwent genetic diversification, and differential mRNA abundance was found in host cells during infection. Notably, there was a significant change in the cellular response, with cross talk between monocytes and natural killer (NK) cells as one of the highly identified pathways...
March 2018: MSphere
https://www.readbyqxmd.com/read/29561936/microcephaly-caused-by-congenital-zika-virus-infection-and-viral-detection-in-maternal-urine-during-pregnancy
#19
Vanessa Couras Regadas, Márcio de Castro E Silva, Lucas Giansante Abud, Luiz Mario Pereira Lopes Labadessa, Rafael Gouvêa Gomes de Oliveira, Cecília Hissae Miyake, Rodolfo Mendes Queiroz
Currently Latin America is undergoing a major epidemic of Zika virus, which is transmitted by Aedes mosquitoes. Concern for Zika virus infection has been increasing as it is suspected of causing brain defects in newborns such as microcephaly and, more recently, potential neurological and autoimmune complications including Guillian-Barré syndrome and acute disseminated encephalomyelitis. We describe a case of virus infection in a 25-year-old woman during the first trimester of her pregnancy, confirmed by laboratory tests only for the detection of viral particles in maternal urine, with imaging studies demonstrating the progression of cranial and encephalic changes in the fetus and later in the newborn, such as head circumference reduction, cerebral calcifications and ventriculomegaly...
January 2018: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29530643/zika-virus-from-an-obscurity-to-a-priority
#20
Cheryl Yi-Pin Lee, Lisa F P Ng
Despite being discovered approximately 70 years ago, Zika virus (ZIKV) has received little attention, until the occurrence of alarming epidemics in the Pacific Islands and Latin America between 2013 and 2016. These series of outbreaks resulted in crippling neurological complications in adults, and congenital deformities in new-borns. The dire outcomes marked ZIKV as a re-emerging pathogen of public health concern. Over a period of two years, extensive studies have been conducted to understand different aspects of ZIKV from pathogen biology to infection, including the immune response during virus-host interplay in established animal models, as well as potential therapeutics against ZIKV infection...
March 9, 2018: Microbes and Infection
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