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https://www.readbyqxmd.com/read/28806866/molecular-screening-and-single-nucleotide-polymorphism-typing-of-molluscum-contagiosum-virus-mcv-from-genital-specimens-between-2012-and-2015
#1
Sedigheh Taghinezhad-S, Amir Hossein Mohseni, Hossein Keyvani, Narges Ghobadi
Background: The present study is the first comprehensive report of the Molluscum contagiosum virus (MCV) in Iran based on the molecular technique for differentiation and typing of the MCV1 and MCV2. Methods: Patients were diagnosed as having tumor-like genital warts less than 5 mm in diameter, and HIV seronegative samples were chosen for this cross-sectional study. TaqMan real-time PCR was used to identify MCV following clinical examination. Typing of the MCV-positive specimens was performed in the SNP A27451G region of MC021L gene...
August 15, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28806793/holding-providers-accountable-for-health-care-outcomes
#2
David W Baker, Mark R Chassin
Federal public reporting and payment programs have increasingly emphasized the measurement of outcomes (such as readmission, health care-associated infections, and mortality). Yet, the criteria for assessing whether outcome measures are accurate and valid enough to use for public reporting, payment, and accreditation are not well-defined. An outcome measure should be used only if the outcome can be influenced substantially by providers (that is, a strong process-outcome link exists) and statistical adjustment can be made for differences in patient populations across providers so that differences in outcomes are truly attributable to differences in the care provided...
August 15, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28806763/genome-wide-regulation-of-electro-acupuncture-on-the-neural-stat5-loss-induced-obese-mice
#3
Shu-Ping Fu, Hao Hong, Sheng-Feng Lu, Chen-Jun Hu, Hou-Xi Xu, Qian Li, Mei-Ling Yu, Chen Ou, Jian-Zhong Meng, Tian-Lin Wang, Lothar Hennighausen, Bing-Mei Zhu
Acupuncture is reported to be effective in treating obesity related illnesses, but its mechanism is still unclear. To investigate this mechanism we applied electro-acupuncture (EA) in a mouse model of obesity and used RNA-seq to identify molecular consequences. Deletion of the transcription factor STAT5 from neurons (Stat5NKO) led to obesity. Acupuncture, in turn, reduced body weight and the ratio of epididymal white adipose tissue (Epi-WAT) to body weight, and it also decreased plasma concentrations of glucose, triglyceride, and cholesterol...
2017: PloS One
https://www.readbyqxmd.com/read/28806755/acquired-von-willebrand-syndrome-in-cardiogenic-shock-patients-on-mechanical-circulatory-microaxial-pump-support
#4
Ulrike Flierl, Jörn Tongers, Dominik Berliner, Jan-Thorben Sieweke, Florian Zauner, Christoph Wingert, Christian Riehle, Johann Bauersachs, Andreas Schäfer
Early use of mechanical circulatory support, e.g. veno-arterial extracorporeal membrane oxygenation (ECMO) or left ventricular unloading by microaxial pump in refractory cardiogenic shock is recommended in current guidelines. Development of acquired von Willebrand Syndrome (AVWS) in patients with left ventricular assist devices (LVADs) and ECMO has been reported. There is an increasing number of patients treated with the Impella® CP microaxial pump for left ventricular unloading. However, the prevalence of AVWS in these high risk patients is unknown and needs to be determined...
2017: PloS One
https://www.readbyqxmd.com/read/28806753/accelerometer-derived-physical-activity-and-sedentary-time-by-cancer-type-in-the-united-states
#5
Keith M Thraen-Borowski, Keith P Gennuso, Lisa Cadmus-Bertram
The 2003-2004 and 2005-2006 cycles of the National Health and Nutrition Examination Survey (NHANES) were among the first population-level studies to incorporate objectively measured physical activity and sedentary behavior, allowing for greater understanding of these behaviors. However, there has yet to be a comprehensive examination of these data in cancer survivors, including short- and long-term survivors of all cancer types. Therefore, the purpose of this analysis was to use these data to describe activity behaviors in short- and long-term cancer survivors of various types...
2017: PloS One
https://www.readbyqxmd.com/read/28806751/the-relative-age-effect-reversal-among-the-national-hockey-league-elite
#6
Luca Fumarco, Benjamin G Gibbs, Jonathan A Jarvis, Giambattista Rossi
Like many sports in adolescence, junior hockey is organized by age groups. Typically, players born after December 31st are placed in the subsequent age cohort and as a result, will have an age advantage over those players born closer to the end of the year. While this relative age effect (RAE) has been well-established in junior hockey and other professional sports, the long-term impact of this phenomenon is not well understood. Using roster data on North American National Hockey League (NHL) players from the 2008-2009 season to the 2015-2016 season, we document a RAE reversal-players born in the last quarter of the year (October-December) score more and command higher salaries than those born in the first quarter of the year...
2017: PloS One
https://www.readbyqxmd.com/read/28806748/temperature-effects-on-gene-expression-and-morphological-development-of-european-eel-anguilla-anguilla-larvae
#7
Sebastian N Politis, David Mazurais, Arianna Servili, Jose-Luis Zambonino-Infante, Joanna J Miest, Sune R Sørensen, Jonna Tomkiewicz, Ian A E Butts
Temperature is important for optimization of rearing conditions in aquaculture, especially during the critical early life history stages of fish. Here, we experimentally investigated the impact of temperature (16, 18, 20, 22 and 24°C) on thermally induced phenotypic variability, from larval hatch to first-feeding, and the linked expression of targeted genes [heat shock proteins (hsp), growth hormone (gh) and insulin-like growth factors (igf)] associated to larval performance of European eel, Anguilla anguilla...
2017: PloS One
https://www.readbyqxmd.com/read/28806717/efficient-construction-of-sparse-radial-basis-function-neural-networks-using-l1-regularization
#8
Xusheng Qian, He Huang, Xiaoping Chen, Tingwen Huang
This paper investigates the construction of sparse radial basis function neural networks (RBFNNs) for classification problems. An efficient two-phase construction algorithm (which is abbreviated as TPCLR1 for simplicity) is proposed by using L1 regularization. In the first phase, an improved maximum data coverage (IMDC) algorithm is presented for the initialization of RBF centers and widths. Then a specialized Orthant-Wise Limited-memory Quasi-Newton (sOWL-QN) method is employed to perform simultaneous network pruning and parameter optimization in the second phase...
July 27, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/28806668/combination-of-electrochemical-biosensor-and-textile-threads-a-microfluidic-device-for-phenol-determination-in-tap-water
#9
F R Caetano, E A Carneiro, D Agustini, L C S Figueiredo-Filho, C E Banks, M F Bergamini, L H Marcolino-Junior
Microfluidic devices constructed using low cost materials presents as alternative for conventional flow analysis systems because they provide advantages as low consumption of reagents and samples, high speed of analysis, possibility of portability and the easiness of construction and maintenance. Herein, is described for the first time the use of an electrochemical biosensor for phenol detection combined with a very simple and efficient microfluidic device based on commercial textile threads. Taking advantages of capillary phenomena and gravity forces, the solution transportation is promoted without any external forces or injection pump...
July 29, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28806665/a-sequential-delivery-system-employing-the-synergism-of-epo-and-ngf-promotes-sciatic-nerve-repair
#10
Wei Zhang, Gongshe Zhou, Yuan Gao, Yan Zhou, Jianheng Liu, Licheng Zhang, Anhua Long, Lihai Zhang, Peifu Tang
The different mechanisms of nerve growth factor (NGF) and erythropoietin (EPO) in promoting repair of peripheral nerve injuries suggest a potential therapeutic application through the synergism of the two. Yet NGF has also been reported to induce early nerve apoptosis after injury. To utilize the potential synergism of NGF and EPO while minimize the possible defect, in this study, we first confirmed the time dependency of NGF caused nerve apoptosis, and then established a sequential and sustained delivery system for NGF and EPO with poly(lactide-co-glycolide) (PLGA), which has been approved by the US FDA for human use because of its injectable, biocompatible, and biodegradable properties...
August 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28806657/two-dimensional-metal-chalcogenides-analogous-nise2-nanosheets-and-its-efficient-electrocatalytic-performance-towards-glucose-sensing
#11
Sakthivel Mani, Sukanya Ramaraj, Shen-Ming Chen, Bose Dinesh, Tse-Wei Chen
Recently, 2D layered transition-metal dichalcogenide materials have received great consideration because of their unique electronic properties, large surface area and high electrocatalytic activity. In this connection, for the first time the similar nanostructured material of NiSe2 nanosheets (NiSe2-NS) has been synthesized by a facile hydrothermal method for electrocatalytic applications. Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), X-ray Photoelectron Spectroscopy (XPS), Energy Dispersive X-ray analysis (EDX), X-ray diffraction spectrum (XRD) results confirmed the formation of NiSe2-NS with required stoichiometry and morphology...
August 8, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28806648/to-embed-or-not-to-embed-a-longitudinal-study-exploring-the-impact-of-curriculum-design-on-the-evidence-based-practice-profiles-of-uk-pre-registration-nursing-students
#12
Laura Scurlock-Evans, Penney Upton, Joanne Rouse, Dominic Upton
BACKGROUND: The use of Evidence-Based Practice (EBP) is increasingly emphasized within healthcare. However, little research has focused on nurses' pre-registration training; particularly regarding the impact of curriculum-design on learning EBP. OBJECTIVES: This study compared the impact of embedding EBP throughout the curriculum, with modular-based teaching, on pre-registration nursing students' EBP profiles. DESIGN: A longitudinal panel study...
July 26, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28806637/want-need-and-habit-as-drivers-of-smoking-behaviour-a-preliminary-analysis
#13
Luis Wehbe, Harveen Kaur Ubhi, Robert West
BACKGROUND AND AIMS: Models of tobacco smoking behaviour propose that anticipated pleasure or satisfaction, the need to alleviate a nicotine-induced drive state and a stimulus-driven impulse potentially play an important role. This study aimed to provide a preliminary assessment of how far urges to smoke are reported by smokers and whether the strength of such urges prior to a quit attempt predicts short-term success at quitting. METHODS: In a prospective study, 566 smokers attending a treatment programme to help smokers quit completed a written questionnaire covering frequency of different types of urge to smoke (automatic impulse - 'automatic urges', anticipated pleasure - 'pleasure urges', and fulfilling a need - 'need urges')...
July 19, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28806626/cryopreservation-of-cynomolgus-macaque-macaca-fascicularis-sperm-with-glycerol-and-ethylene-glycol-and-its-effect-on-sperm-specific-ion-channels-catsper-and-hv1
#14
Bingbing Chen, Shanshan Li, Yaping Yan, Yanchao Duan, Shaohui Chang, Hong Wang, Weizhi Ji, Xin Wu, Wei Si
The cryoprotective agent (CPA) is one of the most important factors that affects the cryosurvival of sperm. The aim of the present study was to compare two different CPAs, glycerol (Gly) and ethylene glycol (EG), on the cryopreservation of cynomolgus macaques sperm and evaluate the effects of cryopreservation on sperm motility, acrosomal integrity, DNA integrity, mitochondrial function and the sperm membrane ion channels CatSper and Hv1. Compared to fresh sperm, cryopreservation with either 0.7 M Gly or EG decreased the sperm motility (79...
August 8, 2017: Theriogenology
https://www.readbyqxmd.com/read/28806625/association-of-changes-among-body-condition-score-during-the-transition-period-with-nefa-and-bhba-concentrations-milk-production-fertility-and-health-of-holstein-cows
#15
R V Barletta, M Maturana Filho, P D Carvalho, T A Del Valle, A S Netto, F P Rennó, R D Mingoti, J R Gandra, G B Mourão, P M Fricke, R Sartori, E H Madureira, M C Wiltbank
Our objective was to evaluate the association between body condition score (BCS) change during the transition period with fertility, non-esterified fatty acids (NEFA) and beta-hydroxybutyrate (BHBA) concentrations, milk yield, and health problems of Holstein cows in a retrospective cohort study. Holstein cows (n = 232) were assessed for BCS (5 point scale; 0.25 point increments) and had blood collected at 21 and 7 d before, on the day of, and 7 and 21 d after calving. Blood samples were assayed for NEFA and BHBA concentrations...
July 27, 2017: Theriogenology
https://www.readbyqxmd.com/read/28806604/chemodiversity-of-tryptamine-derived-alkaloids-in-six-costa-rican-palicourea-species-rubiaceae-palicoureeae
#16
Andreas Berger, Elias Tanuhadi, Lothar Brecker, Johann Schinnerl, Karin Valant-Vetschera
We report 14 harmala and tryptamine-iridoid alkaloids with various tri-, tetra- and pentacyclic cores from leaves and stem bark of six species of the large and complex neotropical genus Palicourea. Among them is the previously undescribed compound deoxostrictosamide which is related to strictosamide, a key intermediate in camptothecin biosynthesis. In addition, we describe the occurrence of 1,2,3,4-tetrahydronorharman-1-one for the first time within Rubiaceae and ophiorine A and B, two alkaloids with an unusual core bearing a betaine function and a zwitterion as new for the genus...
August 11, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28806584/transfer-of-tritium-into-laying-hen-s-meat-and-eggs-at-prolonged-intake-with-atmospheric-air-water-and-grass-meal
#17
Zh А Baigazinov, S N Lukashenko, S S Karatayev, А V Panitski, А S Mamyrbayeva, S А Baigazy, T Ye Kozhakhanov, L F Subbotina
Following a continuous intake of tritium (T) by laying hens' over a 55 day period, an increase of НТО concentration both in eggs and meat was observed over the first 2 weeks for intakes via inhalation and ingestion of water and grass meal. After this time, equilibrium of the T in these products occurred. It was found that when the intake of HTO is from water, air and grass meal, the ratio of its activity concentration in muscular tissue to that in eggs does not exceed 1, 4, and 6 respectively. The ratio of ОBТ concentration to that of НТО in the meat of hens (ОBТ/HTO) when intakes were from water, air and grass meal were 0...
August 11, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28806571/separation-and-characterization-of-allergic-polymerized-impurities-in-cephalosporins-by-2d-hpsec%C3%A3-lc-it-tof-ms
#18
Yu Xu, DanDan Wang, Lan Tang, Jian Wang
Eleven unknown allergic impurities in cefodizime, cefmenoxime and cefonicid were separated and characterized by a trap-free two-dimensional high performance size exclusion chromatography (HPSEC) and reversed phase liquid chromatography (RP-HPLC) coupled to high resolution ion trap/time-of-flight mass spectrometry (2D-HPSEC×LC-IT-TOF MS) with positive and negative modes of electrospray ionization method. Separation and characterization the allergic polymerized impurities in β-lactam antibiotics were on the basis of column-switching technique which effectively combined the advantages of HPSEC and the ability of RP-HPLC to identify the special impurities...
August 2, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28806569/metabolic-profiling-of-dehydrodiisoeugenol-using-xenobiotic-metabolomics
#19
Qian-Qian Lv, Xiao-Nan Yang, Dong-Mei Yan, Wei-Qing Liang, Hong-Ning Liu, Xiu-Wei Yang, Fei Li
Dehydrodiisoeugenol (DDIE), a representative and major benzofuran-type neolignan in Myristica fragrans Houtt., shows anti-inflammatory and anti-bacterial actions. In order to better understand its pharmacological properties, xenobiotic metabolomics was used to determine the metabolic map of DDIE and its influence on endogenous metabolites. Total thirteen metabolites of DDIE were identified through in vivo and in vitro metabolism, and seven of them were reported for the first time in the present study. The identity of DDIE metabolites was achieved by comparison of the MS/MS fragmentation pattern with DDIE using ultra-performance chromatography electrospray ionization quadrupole time-of-flight mass spectrometry (UPLC-ESI- QTOFMS)...
July 31, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28806534/knockdown-of-snail-inhibits-epithelial-mesenchymal-transition-of-human-laryngeal-squamous-cell-carcinoma-hep-2-cells-through-vdr-signaling-pathway
#20
Xue Zhao, Dan Yu, Jingpu Yang, Kai Xue, Yan Liu, Chunshun Jin
It has been well-documented that Snail plays a decisive role in various tumors. However, the direct effect of Snail on laryngeal squamous cell carcinoma (LSCC) has not been elaborated. In this study, we firstly detected the expression of Snail in 14 samples of patients with LSCC and found that its content was high in cancer tissues compared with adjacent tissues. Then we established LSCC Hep-2 cells with Snail silencing and validated the knockdown efficiency by western blotting and real-time PCR. Results showed that silencing of Snail significantly inhibited the ability of adhesion, migration, and invasion of Hep-2 cells...
August 14, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
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