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https://www.readbyqxmd.com/read/29053483/sex-specific-outcomes-after-transcatheter-aortic-valve-replacement-a-review-of-the-literature
#1
Yasameen Azarbaijani, Kathryn O'Callaghan, William E Sanders, Changfu Wu, John Laschinger, Danica Marinac-Dabic, David G Strauss, Daniel A Canos, Robbert Zusterzeel
Transcatheter aortic valve replacement (TAVR) is a safe and effective therapy for aortic valve replacement in patients ineligible for or at high risk for surgery. However, outcomes after TAVR based on an individual's sex remain to be fully elucidated. We searched PUBMED and EMBASE using the keywords: 'transcatheter aortic valve replacement', 'transcatheter aortic valve implantation', 'sex differences', 'gender', 'sex characteristics' and collected information on baseline features, procedural characteristics and post-procedural outcomes in women...
October 9, 2017: Cardiology in Review
https://www.readbyqxmd.com/read/29053434/alpha-gal-inactivated-heart-valve-bioprostheses-exhibit-an-anti-calcification-propensity-similar-to-knockout-tissues
#2
Filippo Naso, Ugo Stefanelli, Edward Buratto, Giovanna Lazzari, Andrea Perota, Cesare Galli, Alessandro Gandaglia
BACKGROUND: Glutaraldehyde (GLA) has been used to crosslink bioprosthetic heart valve (BHVs) tissues to enhance their stability, besides ensuring a satisfactory degree of immunological tolerance. Unfortunately, GLA fixation does not guarantee a complete tissue biocompatibility of BHVs in currently used devices. The interaction between preformed human anti-alpha-Gal antibody and alpha-Gal antigens promotes the calcification of GLA-treated alpha-Gal-positive tissue. Recently, an alarming correlation between the presence of the alpha-Gal epitope and a premature BHVs degeneracy was reported...
October 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29052748/-heart-valve-disesases-how-sufficient-is-the-knowledge-of-the-german-population
#3
L Gaede, J Blumenstein, C Liebetrau, O Dörr, W-K Kim, C Hamm, A Elsässer, H Nef, H Möllmann
To evaluate the awareness and knowledge of the German population regarding diseases in general, a survey of 1446 people aged 60 years or older was conducted in 14 German towns. The focus was on heart valve diseases with special emphasis on aortic valve stenosis (AS). While cancer was the disease that respondents were most concerned about (25.2%), only 3.3% were concerned about heart valve diseases. In this respect, the knowledge was broadly limited: only 7.4% of participants claimed to have some familiarity with heart valve diseases and only 12...
October 20, 2017: Herz
https://www.readbyqxmd.com/read/29050627/outcomes-for-the-commercial-use-of%C3%A2-self-expanding-prostheses-in-transcatheter-aortic-valve-replacement-a-report-from-the-sts-acc-tvt-registry
#4
Paul Sorajja, Susheel Kodali, Michael J Reardon, Wilson Y Szeto, Stanley J Chetcuti, James Hermiller, Sharla Chenoweth, David H Adams, Jeffrey J Popma
OBJECTIVES: The authors sought to compare the outcomes of commercial transcatheter aortic valve replacement (TAVR) with the repositionable Evolut R platform to those observed with the CoreValve device in the Society of Thoracic Surgeons (STS)/American College of Cardiology (ACC) Transcatheter Valve Therapy (TVT) Registry. BACKGROUND: TAVR continues to evolve, with rapid adoption of iterative changes for commercial practice. Insight into the outcomes of this adoption is needed...
October 23, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29050623/death-and-dialysis-after-transcatheter-aortic-valve-replacement-an-analysis-of-the-sts-acc-tvt-registry
#5
James W Hansen, Andrew Foy, Pradeep Yadav, Ian C Gilchrist, Mark Kozak, Amanda Stebbins, Roland Matsouaka, Sreekanth Vemulapalli, Alice Wang, Dee Dee Wang, Marvin H Eng, Adam B Greenbaum, William O O'Neill
OBJECTIVES: The authors sought to elucidate the true incidence of renal replacement therapy (RRT) after transcatheter aortic valve replacement (TAVR). BACKGROUND: There is a wide discrepancy in the reported rate of RRT after TAVR (1.4% to 40%). The true incidence of RRT after TAVR is unknown. METHODS: The STS/ACC TVT (Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy) registry was linked to the Centers for Medicare & Medicaid database to identify all patients that underwent TAVR from November 2011 through September 2015 and their outcomes...
October 23, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29049667/when-can-computed-tomography-fissure-analysis-replace-chartis-collateral-ventilation-assessment-in-the-prediction-of-patients-with-emphysema-who-might-benefit-from-endobronchial-valve-therapy
#6
Alfonso Fiorelli, Mario Santini, Pallav Shah
A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was when can computed tomography-fissure analysis replace Chartis collateral ventilation assessment in the prediction of patients with emphysema who might benefit from endobronchial valve therapy? Twelve papers were chosen to answer the question. The authors, date, journal, country of publication and study type; patient group studied; relevant outcomes and results of these papers were tabulated. Five studies retrospectively compared the prognostic value of 2 methods...
September 5, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049534/high-frequency-percussive-ventilation-in-cardiac-surgery-patients-failing-mechanical-conventional-ventilation
#7
Ivan Wong, Berhane Worku, Jeremy A Weingarten, Alexander Ivanov, Felix Khusid, Ashwad Afzal, Robert F Tranbaugh, Iosif Gulkarov
OBJECTIVES: Failure of mechanical conventional ventilation (MCV) after cardiac surgery portends a dismal prognosis, with extracorporeal membrane oxygenation frequently utilized as a salvage therapy. We describe our experience with high-frequency percussive ventilation (HFPV) as a rescue therapy for hypoxaemia refractory to MCV after cardiac surgery. METHODS: In a 6-year retrospective analysis from 2009 to 2015, we identified 16 subjects who required HFPV after cardiac surgery...
July 21, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29045310/risk-of-stroke-after-transcatheter-prosthetic-aortic-valve-implant-with-aortic-bioprosthesis-subclinical-thrombosis-and-possible-therapeutic-implications
#8
Giuseppe Di Pasquale, Gloria V Coutsoumbas, Silvia Zagnoni
: Many factors could increase the risk of stroke after transcatheter prosthetic aortic valve implant, mainly related to the procedure itself, or to the type of valvular prosthesis, or to the presence of atrial fibrillation. There is a wide variability in the antithrombotic treatment utilized in clinical practice, as far as the choice of drugs (anticoagulant, single or dual antiplatelet treatment), and its optimal duration. The most popular therapeutic strategy, also recommended by the Scientific Societies, is dual antiplatelet (aspirin and clopidogrel) for the first 3-6 months then switching to single antiplatelet (usually aspirin), limiting oral anticoagulant therapy only to those patients with other primary indication to the treatment...
October 16, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29045277/determinants-of-improvement-in-cardiopulmonary-exercise-testing-after-left-ventricular-assist-device-implantation
#9
Andrew N Rosenbaum, Shannon M Dunlay, Naveen L Pereira, Thomas G Allison, Simon Maltais, John M Stulak, Lyle D Joyce, Sudhir S Kushwaha
Although improvement in cardiac output and hemodynamic parameters is routinely demonstrated in patients implanted with continuous-flow left ventricular assist devices (CF-LVADs), improvement in exercise capacity is inconsistently seen. Our purpose was to determine whether native cardiac factors, LVAD factors, or comorbid factors were associated with lack of improvement. Review of all patients undergoing preimplant cardiopulmonary exercise testing (CPET) and CPET on LVAD therapy at one institution was performed between 2007 and 2014 (n = 49)...
October 18, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29042864/recent-advances-in-pediatric-interventional-cardiology
#10
REVIEW
Seong-Ho Kim
During the last 10 years, there have been major technological achievements in pediatric interventional cardiology. In addition, there have been several advances in cardiac imaging, especially in 3-dimensional imaging of echocardiography, computed tomography, magnetic resonance imaging, and cineangiography. Therefore, more types of congenital heart diseases can be treated in the cardiac catheter laboratory today than ever before. Furthermore, lesions previously considered resistant to interventional therapies can now be managed with high success rates...
August 2017: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/29042413/mitral-leaflet-changes-following-myocardial-infarction-clinical-evidence-for-maladaptive-valvular-remodeling
#11
Jonathan Beaudoin, Jacob P Dal-Bianco, Elena Aikawa, Joyce Bischoff, J Luis Guerrero, Suzanne Sullivan, Philipp Emanuel Bartko, Mark D Handschumacher, Dae-Hee Kim, Jill Wylie-Sears, Jacob Aaron, Robert A Levine
BACKGROUND: Ischemic mitral regurgitation (MR) is classically ascribed to functional restriction of normal leaflets, but recent studies have suggested post-myocardial infarction (MI) mitral valve (MV) leaflet fibrosis and thickening, challenging valve normality. Progression of leaflet thickness post-MI has not been studied. We hypothesized that excessive MV remodeling post-MI contributes to MR. Our objectives are to characterize MV changes after MI and relate them to MR. METHODS AND RESULTS: Three groups of 40 patients with serial echocardiograms over a mean of 23...
November 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29042398/peripheral-artery-disease-and-transcatheter-aortic-valve-replacement-outcomes-a-report-from-the-society-of-thoracic-surgeons-american-college-of-cardiology-transcatheter-therapy-registry
#12
Alexander C Fanaroff, Pratik Manandhar, David R Holmes, David J Cohen, J Kevin Harrison, G Chad Hughes, Vinod H Thourani, Michael J Mack, Matthew W Sherwood, W Schuyler Jones, Sreekanth Vemulapalli
BACKGROUND: Peripheral artery disease (PAD) is associated with increased cardiovascular mortality, and PAD risk factors overlap with those for aortic stenosis. The prevalence and outcomes associated with PAD in a population undergoing transcatheter aortic valve replacement (TAVR) are unknown. METHODS AND RESULTS: Using the Society of Thoracic Surgeons/Transcatheter Valve Therapy Registry linked to Medicare claims data, we identified patients ≥65 years old undergoing TAVR from 2011 to 2015...
October 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29040413/bilateral-cavitary-multidrug-or-extensively-drug-resistant-tuberculosis-role-of-surgery
#13
Galina Yu Marfina, Kirill B Vladimirov, Armen O Avetisian, Anna A Starshinova, Grigorii G Kudriashov, Evgenii G Sokolovich, Piotr K Yablonskii
OBJECTIVES: Cavitary disease and bilateral lesions are among the risk factors for poor outcome of pulmonary tuberculosis (TB). Our aim was to explore the value and limits of surgery in patients with advanced TB. METHODS: A retrospective study of 57 consecutive patients who underwent thoracic surgery for culture-positive bilateral cavitary pulmonary TB was performed. Forty-four (77.2%) patients were men and 13 (22.8%) patients were women; their ages were in the range of 18-61 years...
October 10, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29034174/rare-case-of-rhizobium-radiobacter-bioprosthetic-mitral-valve-endocarditis
#14
Ryan Halas, Chris Jacob, Karun Badwal, Rafi Mir
Rhizobium radiobacter is an aerobic, gram negative, rod-shaped, bacterium typically found in the soil. Commonly a plant pathogen, it is also a rare human pathogen causing serious disease. Risk factors for infection include neutropenia, leukopenia, catheters, hospitalization, and low CD4+ lymphocyte count, especially in patients with malignancy or human immunodeficiency virus. There is currently limited literature to establish a definitive guideline for antimicrobial therapy and obtaining susceptibilities from a specialized laboratory is appropriate...
2017: IDCases
https://www.readbyqxmd.com/read/29031176/a-case-of-dedifferentiated-liposarcoma-of-the-heart-and-stomach
#15
Yoichi Hisata, Yuichi Tasaki, Satoshi Kozaki, Takafumi Yamada
INTRODUCTION: Liposarcoma of the heart and stomach is rare. PRESENTAION OF CASE: We report a case of liposarcoma in both organs with dedifferentiated histology. A patient was referred to our hospital with anorexia and weight loss. Upper gastrointestinal tract endoscopy revealed 5-10-mm elevated lesions, and echocardiography and computed tomography showed tumorous lesions in the left atrium. Tumor resection and mitral valve replacement were performed, and biopsy was performed for the gastric tumor...
October 6, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29031049/heart-valve-scaffold-fabrication-bioinspired-control-of-macro-scale-morphology-mechanics-and-micro-structure
#16
Antonio D'Amore, Samuel K Luketich, Giuseppe M Raffa, Salim Olia, Giorgio Menallo, Antonino Mazzola, Flavio D'Accardi, Tamir Grunberg, Xinzhu Gu, Michele Pilato, Marina V Kameneva, Vinay Badhwar, William R Wagner
Valvular heart disease is currently treated with mechanical valves, which benefit from longevity, but are burdened by chronic anticoagulation therapy, or with bioprosthetic valves, which have reduced thromboembolic risk, but limited durability. Tissue engineered heart valves have been proposed to resolve these issues by implanting a scaffold that is replaced by endogenous growth, leaving autologous, functional leaflets that would putatively eliminate the need for anticoagulation and avoid calcification. Despite the diversity in fabrication strategies and encouraging results in large animal models, control over engineered valve structure-function remains at best partial...
October 6, 2017: Biomaterials
https://www.readbyqxmd.com/read/29030859/outpatient-parenteral-antimicrobial-therapy-in-enterococcus-faecalis-infective-endocarditis
#17
M V Gil-Navarro, L E Lopez-Cortes, R Luque-Marquez, J Galvez-Acebal, A de Alarcon-Gonzalez
WHAT IS KNOWN AND OBJECTIVE: Enterococcus faecalis is the third most common causal agent of infective endocarditis. Currently, the treatment recommended is a combination of ampicillin (2 g/4 h) plus ceftriaxone (2 g/12 h), so patients must remain hospitalized for almost 6 weeks to receive the treatment. They are not generally included in outpatient parenteral antimicrobial therapy programs because 2 different electronic pumps are required to administer these 2 antibiotics. To enable the treatment of patients with E...
October 13, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29030013/outcomes-of-patients-at-estimated-low-surgical-risk-undergoing-transcatheter-aortic-valve-implantation-with-balloon-expandable-prostheses
#18
Leire Unzué, Eulogio García, Rodrigo Teijeiro, Belén Díaz Antón, Miguel Rodríguez Del Río, Jorge Solís, Belen Rubio Alonso, Juan Medina, Francisco José Rodríguez Rodrigo, Francisco Javier Parra
INTRODUCTION AND OBJECTIVES: Transcatheter aortic-valve implantation (TAVI) is an accepted treatment for patients with severe aortic stenosis and high surgical risk. However, there is lack in data about TAVI in low-risk patients that are already being treated with this therapy in some clinical contexts. METHODS: A retrospective analysis of patients treated with transfemoral TAVI using Edwards Sapien prosthesis in one center was performed, classifying the patients into three groups according to the surgical risk (high/intermediate/low risk for STS score>8/4-8/<4)...
August 30, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29029058/inter-ethnic-differences-in-valve-morphology-valvular-dysfunction-and-aortopathy-between-asian-and-european-patients-with-bicuspid-aortic-valve
#19
William K F Kong, Madelien V Regeer, Kian K Poh, James W Yip, Philippe J van Rosendael, Tiong C Yeo, Edgar Tay, Vasileios Kamperidis, Enno T van der Velde, Bart Mertens, Nina Ajmone Marsan, Victoria Delgado, Jeroen J Bax
Background: Transcatheter aortic valve replacement (TAVR) has been shown safe and feasible in patients with bicuspid aortic valve (BAV) morphology. Evaluation of inter-ethnic differences in valve morphology and function and aortic root dimensions in patients with BAV is important for the worldwide spread of this therapy in this subgroup of patients. Comparisons between large European and Asian cohorts of patients with BAV have not been performed, and potential differences between populations may have important implications for TAVR...
October 6, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29027509/multiply-adjusted-comparisons-a-meta-analysis-method-to-compare-single-arm-clinical-trial-data-to-literature-results-regarding-a-competitor
#20
Dietmar Boethig, Hartmut Hecker
Prospective randomized controlled trials are difficult to obtain if a promising new therapy has to be tested against seemingly obsolete alternatives. One method to address this problem is to compare the results of (multicentre) trials to literature results. However, previous treatment-era changes and population-dependent results complicate objective comparisons. The presented approach describes a method to objectify such comparisons in cases in which individual raw data regarding a new therapy have to be compared to summary results regarding a conventional alternative published in the literature...
January 1, 2017: Statistical Methods in Medical Research
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