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https://www.readbyqxmd.com/read/28738662/highly-efficient-enrichment-of-low-abundance-intact-proteins-by-core-shell-structured-fe3o4-chitosan-graphene-composites
#1
Peng Zhang, Xiaoni Fang, Guoquan Yan, Mingxia Gao, Xiangmin Zhang
In proteomics research, the screening and monitoring of disease biomarkers is still a major challenge, mainly due to their low concentration in biological samples. However, the universal enrichment of intact proteins has not been further studied. In this work, we developed a Fe3O4-chitosan@graphene (Fe3O4-CS@G) core-shell composite to enrich low-abundance proteins from biological samples. Fe3O4-CS@G composite holds chitosan layer decorated Fe3O4 core, which improves the hydrophilicity of materials greatly. Meanwhile, the graphene nanosheets shell formed via electrostatic assembly endows the composite with huge surface area (178m(2)/g)...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738647/development-of-an-analytical-methodology-for-obtaining-quantitative-mass-concentrations-from-laap-tof-ms-measurements
#2
Rachel Gemayel, Brice Temime-Roussel, Nathalie Hayeck, Adrien Gandolfo, Stig Hellebust, Sasho Gligorovski, Henri Wortham
Laser ablation aerosol particle-time of flight mass spectrometer (LAAP-ToF-MS) measures the size number of particles, and chemical composition of individual particles in real-time. LAAP-ToF-MS measurements of chemical composition are difficult to quantify, mostly because the instrument sensitivities to various chemical species in the multicomponent atmospheric aerosol particles are unknown. In this study, we investigate a field-based approach for quantitative measurements of ammonium, nitrate, sulfate, OC, and EC, in size-segregated atmospheric aerosols, by LAAP-ToF-MS using concurrent measurements from high-resolution time-of-flight aerosol mass spectrometer (HR-ToF-AMS), and multi-angle absorption photometer (MAAP)...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738640/new-insights-in-forensic-chemistry-nir-chemometrics-analysis-of-toners-for-questioned-documents-examination
#3
Stefano Materazzi, Roberta Risoluti, Sara Pinci, Francesco Saverio Romolo
Near-Infrared spectroscopy (NIRs) coupled to chemometrics was investigated for the first time as a new tool for the analysis of black toners to evaluate its application in forensic cases. Ten black toners from four manufacturers were included in this study and the acquired spectra were compared in order to differentiate toners. Multivariate statistical analysis based on Principal Component Analysis (PCA) was considered to develop a model of comparison of toners in questioned documents. Results demonstrated the capabilities of the approach NIR/Chemometrics to correctly identify toners when printed on different papers and to be not affected by the printing process...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738626/elimination-of-interference-from-water-in-kbr-disk-ft-ir-spectra-of-solid-biomaterials-by-chemometrics-solved-with-kinetic-modeling
#4
Sherald H Gordon, Rogers E Harry-O'kuru, Abdellatif A Mohamed
Infrared analysis of proteins and polysaccharides by the well known KBr disk technique is notoriously frustrated and defeated by absorbed water interference in the important amide and hydroxyl regions of spectra. This interference has too often been overlooked or ignored even when the resulting distortion is critical or even fatal, as in quantitative analyses of protein secondary structure, because the water has been impossible to measure or eliminate. Therefore, a new chemometric method was devised that corrects spectra of materials in KBr disks by mathematically eliminating the water interference...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738587/a-novel-calibration-strategy-based-on-background-correction-for-quantitative-circular-dichroism-spectroscopy
#5
Qi Zuo, Shun Xiong, Zeng-Ping Chen, Yao Chen, Ru-Qin Yu
When using circular dichroism (CD) spectroscopy for quantitative analysis, the samples to be analyzed must be free of light-absorbing interferences. However, in real-world samples, the presence of background absorbers is practically unavoidable. The difference in the matrices between the real-world samples to be analyzed and the standard samples (on which either univariate or multivariate calibration model was built) would result in systematic errors in the quantification results of CD spectroscopy. In this contribution, a novel calibration strategy for quantitative CD spectroscopic analysis was proposed...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738582/metaboqc-a-tool-for-correcting-untargeted-metabolomics-data-with-mass-spectrometry-detection-using-quality-controls
#6
Mónica Calderón-Santiago, María A López-Bascón, Ángela Peralbo-Molina, Feliciano Priego-Capote
Nowadays most metabolomic studies involve the analysis of large sets of samples to find a representative metabolite pattern associated to the factor under study. During a sequence of analyses the instrument signals can be subjected to the influence of experimental variability sources. Implementation of quality control (QC) samples to check the contribution of experimental variability is the most common approach in metabolomics. This practice is based on the filtration of molecular entities experiencing a variation coefficient higher than that measured in the QC data set...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738558/elemental-source-attribution-signatures-for-calcium-ammonium-nitrate-can-fertilizers-used-in-homemade-explosives
#7
Carlos G Fraga, Alexander V Mitroshkov, Nikhil S Mirjankar, Brian P Dockendorff, Angie M Melville
Calcium ammonium nitrate (CAN) is a widely available fertilizer composed of ammonium nitrate (AN) mixed with some form of calcium carbonate such as limestone or dolomite. CAN is also frequently used to make homemade explosives. The potential of using elemental profiling and chemometrics to match both pristine and reprocessed CAN fertilizers to their factories of origin for use in future forensic investigations was examined. Inductively coupled plasma-mass spectrometry (ICP-MS) was used to determine the concentrations of 64 elements in 125 samples from 11 CAN stocks from 6 different CAN factories...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738531/surface-complexation-modeling-of-cu-ii-sorption-to-montmorillonite-bacteria-composites
#8
Chengcheng Qu, Mingkai Ma, Wenli Chen, Peng Cai, Qiaoyun Huang
Surface complexation modeling, isothermal titration calorimetry, and batch adsorption were employed to characterize the adsorption of Cu onto montmorillonite, Pseudomonas putida X4, and their composites at mass ratios of 2:1, 6:1, and 12:1, respectively. Different enthalpy values were found for Cu adsorption to permanent (-6.43kJ/mol) and variable charge sites (8.51kJ/mol) on montmorillonite. The component additivity (CA) method was used to predict the adsorption of Cu on the composites by combining end member models for montmorillonite and P...
July 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28738380/scoring-neuropsychological-tests-what-corrections-need-to-be-considered
#9
Yassar Alamri
No abstract text is available yet for this article.
July 24, 2017: European Neurology
https://www.readbyqxmd.com/read/28738364/risk-factors-for-community-acquired-pneumonia-in-adults-a-systematic-review-of-observational-studies
#10
Jordi Almirall, Mateu Serra-Prat, Ignasi Bolíbar, Valentina Balasso
We performed a systematic review of the literature to establish conclusive evidence of risk factors for community-acquired pneumonia (CAP). Observational studies (cross-sectional, case-control, and cohort studies) the primary outcome of which was to assess risk factors for CAP in both hospitalized and ambulatory adult patients with radiologically confirmed pneumonia were selected. The Newcastle-Ottawa Scale specific for cohort and case-control designs was used for quality assessment. Twenty-nine studies (20 case-control, 8 cohort, and 1 cross-sectional) were selected, with 44...
July 25, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28738326/difficulty-in-the-cytodiagnosis-of-mammary-analogue-secretory-carcinoma-survey-of-109-cytologists-with-a-case-originating-from-a-minor-salivary-gland
#11
Keita Kai, Akimichi Minesaki, Kumiko Suzuki, Mikio Monji, Mitsuo Nakamura, Hisayuki Tsugitomi, Yuichiro Kuratomi, Shinichi Aishima
BACKGROUND: Mammary analogue secretory carcinoma (MASC) of the salivary gland shows morphologic similarities and shares an immunophenotype and characteristic ETV6-NTRK3 translocation with secretory carcinoma of the breast. We present a buccal case of MASC along with a survey-based debate about its cytologic diagnosis by fine-needle aspiration (FNA). CASE: FNA of the buccal nodule of a 58-year-old Japanese man was initially performed by 3 cytologists who gave different assessments of the Papanicolaou classification (i...
July 25, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/28738288/it-doesn-t-matter-what-you-say-fmri-correlates-of%C3%A2-voice-learning-and-recognition-independent-of%C3%A2-speech-content
#12
Romi Zäske, Bashar Awwad Shiekh Hasan, Pascal Belin
Listeners can recognize newly learned voices from previously unheard utterances, suggesting the acquisition of high-level speech-invariant voice representations during learning. Using functional magnetic resonance imaging (fMRI) we investigated the anatomical basis underlying the acquisition of voice representations for unfamiliar speakers independent of speech, and their subsequent recognition among novel voices. Specifically, listeners studied voices of unfamiliar speakers uttering short sentences and subsequently classified studied and novel voices as "old" or "new" in a recognition test...
June 27, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28738279/development-and-modification-of-conventional-ouali-model-for-tensile-modulus-of-polymer-carbon-nanotubes-nanocomposites-assuming-the-roles-of-dispersed-and-networked-nanoparticles-and-surrounding-interphases
#13
Yasser Zare, Kyong Yop Rhee
In this paper, conventional Ouali model for tensile modulus of composites is developed for polymer/carbon nanotubes (CNT) nanocomposites (PCNT) assuming the influences of filler network and dispersed nanoparticles above percolation threshold as well as the interphases between polymer host and nanoparticles which reinforce the nanocomposite and facilitate the networking. The developed model is simplified, because the characteristics of dispersed nanoparticles and surrounding interphase cannot significantly change the modulus of PCNT...
July 17, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28738235/treatment-decisions-in-metastatic-colorectal-cancer-beyond-first-and-second-line-combination-therapies
#14
REVIEW
A Vogel, R D Hofheinz, S Kubicka, D Arnold
Median overall survival (OS) of patients with metastatic colorectal cancer (mCRC) has reached up to 30months in recent clinical trials of first line therapies. Following disease progression after the standard in both, 1st and 2nd line, combination chemotherapy with monoclonal antibodies, many patients maintain a good performance status and a significant proportion is motivated to undergo further therapy. Choices of treatment beyond the second line setting for mCRC are therefore becoming increasingly important...
May 4, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28738191/comparison-of-dental-implant-performance-following-vertical-alveolar-bone-augmentation-with-alveolar-distraction-osteogenesis-or-autogenous-onlay-bone-grafts-a-retrospective-cohort-study
#15
Kai Zhao, Feng Wang, Wei Huang, Yiqun Wu
PURPOSE: The aim of this retrospective study was to compare the performance of implants placed after alveolar distraction osteogenesis (ADO) or autogenous onlay bone grafting (AOBG) based on implant survival, peri-implant bone resorption, and clinical parameters. MATERIALS AND METHODS: From February 2008 to July 2012, 17 patients (6 women and 11 men) with implant placement after ADO (group 1, n = 8) or AOBG (group 2, n = 9) were included in this retrospective study...
July 1, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28738127/early-onset-alzheimer-disease-and-candidate-risk-genes-involved-in-endolysosomal-transport
#16
Brian W Kunkle, Badri N Vardarajan, Adam C Naj, Patrice L Whitehead, Sophie Rolati, Susan Slifer, Regina M Carney, Michael L Cuccaro, Jeffery M Vance, John R Gilbert, Li-San Wang, Lindsay A Farrer, Christiane Reitz, Jonathan L Haines, Gary W Beecham, Eden R Martin, Gerard D Schellenberg, Richard P Mayeux, Margaret A Pericak-Vance
Importance: Mutations in APP, PSEN1, and PSEN2 lead to early-onset Alzheimer disease (EOAD) but account for only approximately 11% of EOAD overall, leaving most of the genetic risk for the most severe form of Alzheimer disease unexplained. This extreme phenotype likely harbors highly penetrant risk variants, making it primed for discovery of novel risk genes and pathways for AD. Objective: To search for rare variants contributing to the risk for EOAD. Design, Setting, and Participants: In this case-control study, whole-exome sequencing (WES) was performed in 51 non-Hispanic white (NHW) patients with EOAD (age at onset <65 years) and 19 Caribbean Hispanic families previously screened as negative for established APP, PSEN1, and PSEN2 causal variants...
July 24, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28738104/psychosocial-profiles-of-temporomandibular-disorder-pain-patients-proposal-of-a-new-approach-to-present-complex-data
#17
Simple Futarmal Kothari, Lene Baad-Hansen, Peter Svensson
AIMS: To propose a visual method to screen and assess psychosocial functioning in temporomandibular disorder (TMD) pain patients in comparison with age- and gender-matched healthy controls by forming individual profiles and to evaluate the association between psychosocial profiles and quantitative sensory testing (QST) findings of TMD pain patients. METHODS: TMD patients (n = 58) and control participants (n = 41) completed a set of questionnaires profiling their psychosocial function, and QST was performed at the temporomandibular joint (TMJ) on both sides of the face in all participants...
July 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28738071/the-pit-trap-a-model-free-bootstrap-procedure-for-inference-about-regression-models-with-discrete-multivariate-responses
#18
David I Warton, Loïc Thibaut, Yi Alice Wang
Bootstrap methods are widely used in statistics, and bootstrapping of residuals can be especially useful in the regression context. However, difficulties are encountered extending residual resampling to regression settings where residuals are not identically distributed (thus not amenable to bootstrapping)-common examples including logistic or Poisson regression and generalizations to handle clustered or multivariate data, such as generalised estimating equations. We propose a bootstrap method based on probability integral transform (PIT-) residuals, which we call the PIT-trap, which assumes data come from some marginal distribution F of known parametric form...
2017: PloS One
https://www.readbyqxmd.com/read/28738067/the-prediction-of-late-onset-preeclampsia-results-from-a-longitudinal-proteomics-study
#19
Offer Erez, Roberto Romero, Eli Maymon, Piya Chaemsaithong, Bogdan Done, Percy Pacora, Bogdan Panaitescu, Tinnakorn Chaiworapongsa, Sonia S Hassan, Adi L Tarca
BACKGROUND: Late-onset preeclampsia is the most prevalent phenotype of this syndrome; nevertheless, only a few biomarkers for its early diagnosis have been reported. We sought to correct this deficiency using a high through-put proteomic platform. METHODS: A case-control longitudinal study was conducted, including 90 patients with normal pregnancies and 76 patients with late-onset preeclampsia (diagnosed at ≥34 weeks of gestation). Maternal plasma samples were collected throughout gestation (normal pregnancy: 2-6 samples per patient, median of 2; late-onset preeclampsia: 2-6, median of 5)...
2017: PloS One
https://www.readbyqxmd.com/read/28738017/distinct-oxysterol-requirements-for-positioning-na%C3%A3-ve-and-activated-dendritic-cells-in-the-spleen
#20
Erick Lu, Eric V Dang, Jeffrey G McDonald, Jason G Cyster
Correct positioning of dendritic cells (DCs) is critical for efficient pathogen encounter and antigen presentation. Epstein-Barr virus-induced gene 2 (EBI2) has been identified as a chemoattractant receptor required for naïve CD4(+)DCIR2(+) DC positioning in response to 7α,25-hydroxycholesterol (7α,25-HC). We now provide evidence that a second EBI2 ligand, 7α,27-HC, is involved in splenic DCIR2(+) DC positioning and homeostasis. Cyp27a1, the enzyme uniquely required for 7α,27-HC synthesis, is expressed by stromal cells in the region of naïve DC localization...
April 7, 2017: Science Immunology
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