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https://www.readbyqxmd.com/read/28319952/regression-based-norms-for-the-symbol-digit-modalities-test-in-the-dutch-population-improving-detection-of-cognitive-impairment-in-multiple-sclerosis
#1
Jessica Burggraaff, Dirk L Knol, Bernard M J Uitdehaag
BACKGROUND/AIMS: Appropriate and timely screening instruments that sensitively capture the cognitive functioning of multiple sclerosis (MS) patients are the need of the hour. We evaluated newly derived regression-based norms for the Symbol Digit Modalities Test (SDMT) in a Dutch-speaking sample, as an indicator of the cognitive state of MS patients. METHODS: Regression-based norms for the SDMT were created from a healthy control sample (n = 96) and used to convert MS patients' (n = 157) raw scores to demographically adjusted Z-scores, correcting for the effects of age, age2, gender, and education...
March 21, 2017: European Neurology
https://www.readbyqxmd.com/read/28319936/correction-fixed-dose-combination-of-ar-13324-and-latanoprost-a-double-masked-28-day-randomised-controlled-study-in-patients-with-open-angle-glaucoma-or-ocular-hypertension
#2
(no author information available yet)
No abstract text is available yet for this article.
July 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28319935/correction-choroidal-thickness-in-children-with-hyperopic-anisometropic-amblyopia
#3
(no author information available yet)
No abstract text is available yet for this article.
July 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28319878/visual-stimuli-modulate-frontal-oscillatory-rhythms-in-a-cortically-blind-patient-evidence-for-top-down-visual-processing
#4
Eda Tipura, Alan J Pegna, Beatrice de Gelder, Olivier Renaud
OBJECTIVE: We investigated neuronal correlates of faces versus non-faces processing in a cortically blind patient (TN) and a group of healthy age-matched controls in order to test electrophysiological correlates of the processing of pertinent stimuli in this patient. METHODS: An EEG paradigm was used, in which intact and scrambled faces were displayed on a screen. First, time-frequency transforms were conducted on the patients' data alone. These oscillations were then compared to the frontal activity of six control participants...
February 23, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28319850/methylation-of-hpa-axis-related-genes-in-men-with-hypersexual-disorder
#5
Jussi Jokinen, Adrian E Boström, Andreas Chatzittofis, Diana M Ciuculete, Katarina Görts Öberg, John N Flanagan, Stefan Arver, Helgi B Schiöth
Hypersexual Disorder (HD) defined as non-paraphilic sexual desire disorder with components of compulsivity, impulsivity and behavioral addiction, and proposed as a diagnosis in the DSM 5, shares some overlapping features with substance use disorder including common neurotransmitter systems and dysregulated hypothalamic-pituitary-adrenal (HPA) axis function. In this study, comprising 67 HD male patients and 39 male healthy volunteers, we aimed to identify HPA-axis coupled CpG-sites, in which modifications of the epigenetic profile are associated with hypersexuality...
March 10, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28319781/systematic-study-of-imidazoles-inhibiting-ido1-via-the-integration-of-molecular-mechanics-and-quantum-mechanics-calculations
#6
Yi Zou, Fang Wang, Yan Wang, Wenjie Guo, Yihua Zhang, Qiang Xu, Yisheng Lai
Indoleamine 2,3-dioxygenase 1 (IDO1) is regarded as an attractive target for cancer immunotherapy. To rationalize the detailed interactions between IDO1 and its inhibitors at the atomic level, an integrated computational approach by combining molecular mechanics and quantum mechanics methods was employed in this report. Specifically, the binding modes of 20 inhibitors was initially investigated using the induced fit docking (IFD) protocol, which outperformed other two docking protocols in terms of correctly predicting ligand conformations...
March 14, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28319768/quantitative-evaluation-of-the-interfacial-interactions-between-a-randomly-rough-sludge-floc-and-membrane-surface-in-a-membrane-bioreactor-based-on-fractal-geometry
#7
Meijia Zhang, Xiaoling Zhou, Liguo Shen, Xiang Cai, Fangyuan Wang, Jianrong Chen, Hongjun Lin, Renjie Li, Xilin Wu, Bao-Qiang Liao
In this paper, a new method for quantification of interfacial interactions between a randomly rough particle and membrane surface was proposed. It was found that sludge flocs in a membrane bioreactor were of apparent fractal characteristics, and could be modeled by the modified two-variable Weierstrass-Mandelbrot (WM) function. By combining the surface element integration (SEI) method, differential geometry and composite Simpson's rule, the quantitation method for calculating such interfacial interactions was further developed...
March 8, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28319706/fire-spread-predictions-sweeping-uncertainty-under-the-rug
#8
Akli Benali, Ana C L Sá, Ana R Ervilha, Ricardo M Trigo, Paulo M Fernandes, José M C Pereira
Predicting fire spread and behavior correctly is crucial to minimize the dramatic consequences of wildfires. However, our capability of accurately predicting fire spread is still very limited, undermining the utility of such simulations to support decision-making. Improving fire spread predictions for fire management purposes, by using higher quality input data or enhanced models, can be expensive, unfeasible or even impossible. Fire managers would benefit from fast and inexpensive ways of improving their decision-making...
March 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28319531/examination-of-the-life-expectancy-of-patients-with-burns-over-20-of-their-total-body-surface-area-in-comparison-to-the-rest-of-the-population
#9
Weissman Oren, Wagman Yonathan, Givon Adi, Radomislensky Irina, Peleg Kobi, Stavrou Demetris, Haik Josef, Tessone Ariel
Patients with extensive burn injuries suffer from multisystem trauma, which affects their medical, psychological, and social well-being for many years. Monitoring those patients has revealed changes in the endocrine, cardiac, and respiratory systems years after the injury. Our study tries to examine whether changes manifest as a higher risk of death during their lifespan, compared with the general population. Data from the years 1998 to 2013 regarding two groups of patients was obtained from a national trauma registry: one group had suffered burns over 20% of their TBSA and survived the hospitalization period and the second group was a control group of patients admitted with minimal trauma (Injury Severity Score = 1-minor injury to a single body region)...
March 13, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28319525/crowdsourcing-to-evaluate-fundus-photographs-for-the-presence-of-glaucoma
#10
Xueyang Wang, Lucy I Mudie, Mani Baskaran, Ching-Yu Cheng, Wallace L Alward, David S Friedman, Christopher J Brady
PURPOSE: To assess the accuracy of crowdsourcing for grading optic nerve images for glaucoma using Amazon Mechanical Turk before and after training modules. MATERIALS AND METHODS: Images (n=60) from 2 large population studies were graded for glaucoma status and vertical cup-to-disc ratio (VCDR). In the baseline trial, users on Amazon Mechanical Turk (Turkers) graded fundus photos for glaucoma and VCDR after reviewing annotated example images. In 2 additional trials, Turkers viewed a 26-slide PowerPoint training or a 10-minute video training and passed a quiz before being permitted to grade the same 60 images...
March 17, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28319517/effects-of-a-lidocaine-loaded-poloxamer-alginate-cacl2-mixture-on-postoperative-pain-and-adhesion-in-a-rat-model-of-incisional-pain
#11
Geun Joo Choi, Hyun Kang, Min Eui Hong, Hwa Yong Shin, Chong Wha Baek, Yong Hun Jung, Younsuk Lee, Jeong Wook Kim, I L Kyu Park, Wan Jin Cho
BACKGROUND: Pain and adhesion are problematic issues after surgery. Lidocaine has analgesics and anti-inflammatory properties, and poloxamer/alginate/CaCl2 (PACM) is a known antiadhesive agent. We hypothesized that the novel combination of lidocaine as chemical barrier and PACM as physical barrier would be beneficial for both postoperative pain and adhesion. The purpose of this study was to investigate the effects of lidocaine-loaded PACM in a rat model of incisional pain. Primary outcome was to evaluate between-group differences for the mechanical withdrawal threshold (MWT) measured by von Frey filament in various concentrations of lidocaine-loaded PACM applied, PACM applied, and sham-operated groups...
March 17, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28319509/a-high-preoperative-pain-and-symptom-profile-predicts-worse-pain-outcomes-for-children-after-spine-fusion-surgery
#12
Terri Voepel-Lewis, Michelle S Caird, Alan R Tait, Shobha Malviya, Frances A Farley, Ying Li, Matthew D Abbott, Tara van Veen, Afton L Hassett, Daniel J Clauw
BACKGROUND: Preoperative pain predicts persistent pain after spine fusion, yet little is understood about the nature of that pain, related symptoms, and how these symptoms relate to postoperative pain outcomes. This prospective study examined children's baseline pain and symptom profiles and the association between a high symptom profile and postoperative outcomes. METHODS: Seventy children (aged 10-17 years) scheduled for correction of idiopathic scoliosis completed pain and symptom surveys during their preoperative visit (ie, pain intensity [0-10 numeric rating scores], a pediatric version of the 2011 fibromyalgia survey criteria [including pain locations and symptom severity scale], neuropathic pain symptoms [painDETECT], and Patient-Reported Outcome Measurement System measures of fatigue, depression, function, pain interference, and pain catastrophizing)...
March 17, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28319491/breaking-down-the-objective-structured-clinical-examination-an-evaluation-of-the-helping-babies-breathe-osces
#13
Teresa L Seto, Meredith E Tabangin, Kathryn K Taylor, Srirama Josyula, Juan Carlos Vasquez, Beena D Kamath-Rayne
INTRODUCTION: Helping Babies Breathe (HBB) is a simulation-based neonatal resuscitation curriculum designed for low-resource settings. At the completion of the workshop, learners complete the following four assessments: a multiple-choice question (MCQ) test, bag-mask ventilation (BMV) checklist, and two objective structured clinical examinations (OSCEs). Objective structured clinical examinations are clinical performance assessments that evaluate learners' skills in simulated scenarios...
March 18, 2017: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
https://www.readbyqxmd.com/read/28319445/nonclinical-pharmacology-toxicology-study-of-aav8-tbg-mldlr-and-aav8-tbg-hldlr-in-a-mouse-model-of-homozygous-familial-hypercholesterolemia
#14
Jenny A Greig, Maria P Limberis, Peter Bell, Shu-Jen Chen, Roberto Calcedo, Daniel J Rader, James M Wilson
The homozygous form of familial hypercholesterolemia (HoFH) is an excellent model for developing in vivo gene therapy in humans. The success of orthotropic liver transplantation in correcting the metabolic abnormalities in HoFH suggests that the correction of low-density lipoprotein receptor (LDLR) expression in hepatocytes via gene therapy should be sufficient for therapeutic efficacy. Vectors based on adeno-associated virus serotype 8 (AAV8) have been previously developed for liver-targeted gene therapy of a number of genetic diseases, including HoFH...
March 2017: Human Gene Therapy. Clinical Development
https://www.readbyqxmd.com/read/28319444/retro-orbital-venous-sinus-delivery-of-raav9-mediates-high-level-transduction-of-brain-and-retina-compared-with-temporal-vein-delivery-in-neonatal-mouse-pups
#15
Alisha M Gruntman, Lin Su, Terence R Flotte
In order to pursue a clinical gene therapy for a human neurologic disease, it is often necessary to perform proof-of-concept trials in mouse models of that disease. In order to demonstrate a potential clinical efficacy, one must be able to select an appropriate vector and route of delivery for the appropriate age group in the disease model. Since many diseases require correction early in life, investigators often need to deliver recombinant adeno-associated viral (rAAV) vectors to neonatal mice. Herein, general central nervous system expression patterns of nuclear GFP following delivery of rAAV by three different routes are reported...
March 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/28319427/new-horizons-in-the-imaging-of-perianal-crohn-s-disease-transperineal-ultrasonography
#16
Cristina Bezzio, Robert V Bryant, Gianpiero Manes, Giovanni Maconi, Simone Saibeni
Perianal disease, most commonly manifest as fistula or abscess formation, affects up to 40% of patients with Crohn's disease. Perianal Crohn's disease is disabling, associated with poor outcomes, and represents a therapeutic challenge for physicians. Correct diagnosis and classification of perianal disease is the first crucial step for appropriate multidisciplinary management. Areas covered: A literature search was performed of the PubMed database using the terms "transperineal ultrasonography", "transperineal ultrasound", "perianal disease", "perianal fistula", "perianal abscess", "magnetic resonance", "endoanal ultrasonography", "endoscopic ultrasound" in combination with "Crohn's disease"...
March 20, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28319387/temperature-dependence-in-the-terahertz-spectrum-of-nicotinamide-anharmonicity-and-hydrogenbonded-network
#17
Masae Takahashi, Nubuyuki Okamura, Xinyi Fan, Hitoshi Shirakawa, Hiroaki Minamide
We have investigated the terahertz-spectral property of nicotinamide focusing on the temperature dependence in the range of 14 to 300 K. We observed that almost all peaks in the terahertz spectrum of the nicotinamide crystal showed a remarkable shift with temperature, whereas the lowest-frequency peak at 34.8 cm-1 showed a negligible shift with temperature. By analyzing the terahertz spectrum with the dispersion-corrected density-functional-theory calculations, we found that the difference in the temperature dependence of the peak shift is well understood in terms of the presence/absence of stretching vibration of the intermolecular hydrogen bond in the mode and the change of cell parameters...
March 20, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28319377/mechanism-and-origins-of-stereoselectivity-in-the-cinchona-thiourea-and-squaramide-catalyzed-asymmetric-michael-addition-of-nitroalkanes-to-enones
#18
Matthew N Grayson
We report density functional theory calculations which examine the mechanism and origins of stereoselectivity of Soós' landmark discovery from 2005 that cinchona thioureas catalyze the asymmetric Michael addition of nitroalkanes to enones. We show that the electrophile is activated by the catalyst's protonated amine and that the nucleophile binds to the thiourea moiety by hydrogen bonding. These results lead to the correction of published mechanistic work which did not consider this activation mode. We have also investigated the corresponding cinchona squaramide-catalyzed reaction and found that it proceeds by the same mechanism, despite the differences in the geometry of the two catalysts' hydrogen bond donating groups, which demonstrates the generality of this mechanistic model...
March 20, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28319203/relationship-between-low-tube-voltage-70-kv-and-the-iodine-delivery-rate-idr-in-ct-angiography-an-experimental-in-vivo-study
#19
Michael M Lell, Ulrike Fleischmann, Hubertus Pietsch, Johannes G Korporaal, Ulrike Haberland, Andreas H Mahnken, Thomas G Flohr, Michael Uder, Gregor Jost
OBJECTIVE: Very short acquisition times and the use of low-kV protocols in CTA demand modifications in the contrast media (CM) injection regimen. The aim of this study was to optimize the use of CM delivery parameters in thoraco-abdominal CTA in a porcine model. MATERIALS AND METHODS: Six pigs (55-68 kg) were examined with a dynamic CTA protocol (454 mm scan length, 2.5 s temporal resolution, 70 s total acquisition time). Four CM injection protocols were applied in a randomized order...
2017: PloS One
https://www.readbyqxmd.com/read/28319192/correction-modular-brain-network-organization-predicts-response-to-cognitive-training-in-older-adults
#20
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pone.0169015.].
2017: PloS One
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