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https://www.readbyqxmd.com/read/28110502/accuracy-and-reproducibility-of-nuclear-cytoplasmic-ratio-assessments-in-urinary-cytology-specimens
#1
Lester J Layfield, Magda Esebua, Shellaine R Frazier, Richard D Hammer, William W Bivin, Van Nguyen, Ilker Ersoy, Robert L Schmidt
BACKGROUND: Evaluation of the nuclear to cytoplasmic ratio is commonly used for assessment of the presence of malignancy and for grading and typing of malignant neoplasms. Despite its widespread usage, little information exists regarding the accuracy and reproducibility of non-automated assessment. METHODS: Forty-seven cells obtained from Papanicolaou stained urine cytologies were assessed by quantitative image analysis for nuclear area and cell area. The nuclear/cytoplasmic ratio was calculated...
February 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28110447/hemispheric-lateralization-of-resting-state-functional-connectivity-of-the-ventral-striatum-an-exploratory-study
#2
Sheng Zhang, Sien Hu, Herta H Chao, Chiang-Shan R Li
Resting-state functional connectivity (rsFC) is widely used to examine cerebral functional organization. The ventral striatum (VS) is critical to motivated behavior, with extant studies suggesting functional hemispheric asymmetry. The current work investigated differences in rsFC between the left (L) and right (R) VS and explored gender differences in the extent of functional lateralization. In 106 adults, we computed a laterality index (fcLI) to query whether a target region shows greater or less connectivity to the L vs R VS...
January 21, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28110382/economic-evaluations-alongside-efficient-study-designs-using-large-observational-datasets-the-pleasant-trial-case-study
#3
Matthew Franklin, Sarah Davis, Michelle Horspool, Wei Sun Kua, Steven Julious
BACKGROUND: Large observational datasets such as Clinical Practice Research Datalink (CPRD) provide opportunities to conduct clinical studies and economic evaluations with efficient designs. OBJECTIVES: Our objectives were to report the economic evaluation methodology for a cluster randomised controlled trial (RCT) of a UK NHS-delivered public health intervention for children with asthma that was evaluated using CPRD and describe the impact of this methodology on results...
January 21, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28110363/bone-morphotypes-of-the-varus-and-valgus-knee
#4
E Thienpont, P E Schwab, O Cornu, J Bellemans, J Victor
BACKGROUND: Coronal deformity correction with total knee arthroplasty (TKA) is an important feature in the treatment of osteoarthritis (OA). The hypothesis of this study was that bone morphology would be different in varus and valgus deformity, both before osteoarthritis development as well as during and after the disease process of OA. MATERIALS AND METHODS: Retrospective study with measurements on preoperative and postoperative full leg standing radiographs of 96 patients who underwent TKA...
January 21, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28110352/effects-of-methylphenidate-on-attention-in-wistar-rats-treated-with-the-neurotoxin-n-2-chloroethyl-n-ethyl-2-bromobenzylamine-dsp4
#5
Joachim Hauser, Andreas Reissmann, Thomas-A Sontag, Oliver Tucha, Klaus W Lange
The aim of this study was to assess the effects of the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4) on attention in rats as measured using the 5-choice-serial-reaction-time task (5CSRTT) and to investigate whether methylphenidate has effects on DSP4-treated rats. Methylphenidate is a noradrenaline and dopamine reuptake inhibitor and commonly used in the pharmacological treatment of individuals with attention deficit/hyperactivity disorder (ADHD). Wistar rats were trained in the 5CSRTT and treated with one of three doses of DSP4 or saline...
January 21, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28110262/tensor-decompositions-for-the-analysis-of-atomic-resolution-electron-energy-loss-spectra
#6
Jakob Spiegelberg, Ján Rusz, Kristiaan Pelckmans
A selection of tensor decomposition techniques is presented for the detection of weak signals in electron energy loss spectroscopy (EELS) data. The focus of the analysis lies on the correct representation of the simulated spatial structure. An analysis scheme for EEL spectra combining two-dimensional and n-way decomposition methods is proposed. In particular, the performance of robust principal component analysis (ROBPCA), Tucker Decompositions using orthogonality constraints (Multilinear Singular Value Decomposition (MLSVD)) and Tucker decomposition without imposed constraints, canonical polyadic decomposition (CPD) and block term decompositions (BTD) on synthetic as well as experimental data is examined...
January 11, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/28110261/structure-and-chemistry-of-epitaxial-ceria-thin-films-on-yttria-stabilized-zirconia-substrates-studied-by-high-resolution-electron-microscopy
#7
Robert Sinclair, Sang Chul Lee, Yezhou Shi, William C Chueh
We have applied aberration-corrected transmission electron microscopy (TEM) imaging and electron energy loss spectroscopy (EELS) to study the structure and chemistry of epitaxial ceria thin films, grown by pulsed laser deposition onto (001) yttria-stabilized zirconia (YSZ) substrates. There are few observable defects apart from the expected mismatch interfacial dislocations and so the films would be expected to have good potential for applications. Under high electron beam dose rate (above about 6000 e(-)/Å(2)s) domains of an ordered structure appear and these are interpreted as being created by oxygen vacancy ordering...
January 6, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/28110179/analysis-the-effect-of-different-geometries-of-afm-s-cantilever-on-the-dynamic-behavior-and-the-critical-forces-of-three-dimensional-manipulation
#8
Moharam Habibnejad Korayem, Maniya B Saraie, Mahdieh B Saraee
An important challenge when using an atomic force microscope (AFM) is to be able to control the force exerted by the AFM for performing various tasks. Nevertheless, the exerted force is proportional to the deflection of the AFM cantilever, which itself is affected by a cantilever's stiffness coefficient. Many papers have been published so far on the methods of obtaining the stiffness coefficients of AFM cantilevers in 2D; however, a comprehensive model is yet to be presented on 3D cantilever motion. The discrepancies between the equations of the 2D and 3D analysis are due to the number and direction of forces and moments that are applied to a cantilever...
January 13, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/28109921/coronary-artery-pet-mr-imaging-feasibility-limitations-and-solutions
#9
Philip M Robson, Marc R Dweck, Maria Giovanna Trivieri, Ronan Abgral, Nicolas A Karakatsanis, Johanna Contreras, Umesh Gidwani, Jagat P Narula, Valentin Fuster, Jason C Kovacic, Zahi A Fayad
OBJECTIVES: The aims of this study were to describe the authors' initial experience with combined coronary artery positron emission tomographic (PET) and magnetic resonance (MR) imaging using (18)F-fluorodeoxyglucose ((18)F-FDG) and (18)F-sodium fluoride ((18)F-NaF) radiotracers, describe common problems and their solutions, and demonstrate the feasibility of coronary PET/MR imaging in appropriate patients. BACKGROUND: Recently, PET imaging has been applied to the aortic valve and regions of atherosclerosis...
January 13, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28109888/improving-structural-brain-images-acquired-with-the-3d-flash-sequence
#10
Jinghua Wang, Lili He, Hairong Zheng, Zhong-Lin Lu
The three-dimension Fast Low Angle SHot Magnetic Resonance Imaging (3D FLASH) sequence has been widely adopted in medical diagnostic imaging because of its availability, simplicity, and high spatial resolution. To improve the quality of structural brain images acquired with the 3D FLASH sequence, we developed a parameter optimization scheme and image inhomogeneity correction methods. The optimal imaging parameters were determined by maximizing gray-matter and white-matter CNR efficiency. Compared to protocols based on published parameters, applying the proposed optimal imaging parameters increased CNR efficiency by >10%...
January 18, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28109876/successful-percutaneous-stenting-of-severe-radiofrequency-induced-pulmonary-vein-stenosis-in-3-veins-post-failed-surgical-correction
#11
Tom De Potter, Etel Silva Garcia, Roel Beelen, Sofia Chatzikyriakou
No abstract text is available yet for this article.
January 11, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28109825/trends-in-coronary-risk-factors-and-electrocardiogram-findings-from-1977-to-2009-with-10-year-mortality-in-japanese-elderly-males-the-tanushimaru-study
#12
Sachiko Nakamura, Hisashi Adachi, Mika Enomoto, Ako Fukami, Eita Kumagai, Yume Nohara, Shoko Kono, Erika Nakao, Akiko Sakaue, Tomoko Tsuru, Nagisa Morikawa, Yoshihiro Fukumoto
BACKGROUND: An understanding of the trends in regard to coronary risk factors and electrocardiogram (ECG) findings has an important role in public health. We investigated the trends in coronary risk factors and main ECG findings in 1977, 1989, 1999, and 2009 in the Japanese cohort of the Seven Countries Study, in Tanushimaru, a typical farming town on Kyushu Island. METHODS AND RESULTS: A total of 1397 subjects (231 in 1977, 332 in 1989, 389 in 1999, and 445 in 2009) were enrolled in this study, and all of them were males aged over 65 years...
January 18, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28109651/late-onset-krabbe-disease-due-to-the-new-galc-p-ala543pro-mutation-with-intriguingly-high-residual-galc-activity-in%C3%A2-vitro
#13
Inge Krägeloh-Mann, Klaus Harzer, Kevin Rostásy, Stefanie Beck-Wödl, Antje Bornemann, Judith Böhringer, Andrea Bevot, Verena Beck, Gisela Merkel, Maria Pechan
BACKGROUND: Krabbe disease (KD) is an inherited leukodystrophy due to a defect in the GALC gene which encodes the lysosomal galactosylceramide β-galactosidase (GALC). About two thirds of patients show the early onset form of KD dominated by cerebral demyelination leading to death in early infancy. Late onset forms include a spectrum of late infantile, juvenile and adult clinical courses. The deficiency of GALC leads to a galactosylceramide lipidosis in which lysosomal storage phenomena are seen almost only at the ultrastructural level...
January 6, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/28109597/weather-influences-feed-intake-and-feed-efficiency-in-a-temperate-climate
#14
Davina L Hill, Eileen Wall
A key goal for livestock science is to ensure that food production meets the needs of an increasing global population. Climate change may heighten this challenge through increases in mean temperatures and in the intensity, duration, and spatial distribution of extreme weather events, such as heat waves. Under high ambient temperatures, livestock are expected to decrease dry matter intake (DMI) to reduce their metabolic heat production. High yielding dairy cows require high DMI to support their levels of milk production, but this may increase susceptibility to heat stress...
January 18, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28109589/effects-of-precalving-body-condition-and-prepartum-feeding-level-on-gene-expression-in-circulating-neutrophils
#15
M A Crookenden, C G Walker, A Heiser, A Murray, V S R Dukkipati, J K Kay, S Meier, K M Moyes, M D Mitchell, J J Loor, J R Roche
Extensive metabolic, physiological, and immunological changes are associated with calving and the onset of lactation. As a result, cows transitioning between pregnancy and lactation are at a greater risk of metabolic and infectious diseases. The ability of neutrophils to mount an effective immune response to an infection is critical for its resolution, and increasing evidence indicates that precalving nutrition affects postpartum neutrophil function. The objectives of the current study were to investigate the effect of 2 precalving body condition scores (BCS; 4 vs...
January 18, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28109581/external-histopathological-validation-of-the-surface-intermediate-base-margin-score
#16
Alessandro Antonelli, Maria Furlan, Mario Sodano, Francesca Carobbio, Regina Tardanico, Simona Fisogni, Claudio Simeone
PURPOSE: The surface, intermediate, and basis (SIB) is a system based on surgeon׳s visual assessment of the thickness of healthy parenchyma remaining on the intrarenal portion of the tumor. This system has been proposed to standardize the nomenclature of the resection technique (RT) during partial nephrectomy (PN). Our study aims at evaluating whether the SIB score visually assigned is related to the thickness of parenchyma measured by microscopy. MATERIALS AND METHODS: Data of 52 patients submitted to PN from April to October 2015 were perspectively collected...
January 18, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28109550/rapid-detection-of-high-risk-enterococcus-faecium-clones-by-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry
#17
Ana R Freitas, Clara Sousa, Carla Novais, Liliana Silva, Helena Ramos, Teresa M Coque, João Lopes, Luísa Peixe
We aimed to explore the potential of matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) for early identification of dominant Enterococcus faecium (Efm) clones involved in human infections. Well-characterized Efm isolates (n=77), analyzed by pulsed-field gel electrophoresis and multilocus sequence typing(eBURST and BAPS [Bayesian analysis of population structure] algorithms), and belonging to different hospital (n=53) and community (n=24) phylogenomic groups, were tested...
December 14, 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28109541/anaemia-as-an-independent-key-risk-factor-for-major-haemorrhage-in-patients-treated-with-vitamin-k-antagonists-results-of-the-score-prospective-cohort
#18
Nora Zenati, Yoann Gaboreau, Cynthia Brousseau Provencher, Pierre Albaladejo, Jean Luc Bosson, Gilles Pernod
INTRODUCTION: Risk scores for the prediction of haemorrhage are poorly predictive of major bleeding. The aim of this study was to refine the estimation of bleeding risk by identifying one or several parameters of prognostic significance among these algorithms. MATERIALS AND METHODS: The SCORE study was a prospective, multicentre cohort study conducted in France in 2009-2010. Patients were eligible if they had received vitamin K antagonist (VKA) for any therapeutic indication for at least 3months...
October 28, 2016: Thrombosis Research
https://www.readbyqxmd.com/read/28109492/audiovisual-materials-are-effective-for-enhancing-the-correction-of-articulation-disorders-in-children-with-cleft-palate
#19
María Del Carmen Pamplona, Pablo Antonio Ysunza, Santiago Morales
INTRODUCTION: Children with cleft palate frequently show speech disorders known as compensatory articulation. Compensatory articulation requires a prolonged period of speech intervention that should include reinforcement at home. However, frequently relatives do not know how to work with their children at home. OBJECTIVE: To study whether the use of audiovisual materials especially designed for complementing speech pathology treatment in children with compensatory articulation can be effective for stimulating articulation practice at home and consequently enhancing speech normalization in children with cleft palate...
February 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28109482/prevalence-and-independent-risk-factors-for-hearing-impairment-among-very-low-birth-weight-infants
#20
Chien-Ho Wang, Chang-Yo Yang, Reyin Lien, Shih-Ming Chu, Jen-Fu Hsu, Ren-Huei Fu, Ming-Chou Chiang
BACKGROUND: Although we've made big strides in perinatal and neonatal care, auditory handicap remains a serious complication in those who were born very premature. OBJECTIVES: The aim was to determine the prevalence and analyze possible risk factors of hearing impairment in very-low-birth-weight (VLBW) infants. MATERIALS AND METHODS: This was a retrospective study by reviewing medical records of all VLBW infants (BW ≤ 1500 g) admitted to NICU of Chang Gung Children's Hospital over 2 years period from Jan...
February 2017: International Journal of Pediatric Otorhinolaryngology
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