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https://www.readbyqxmd.com/read/27915451/interobserver-agreement-in-detection-of-white-globe-appearance-and-the-ability-of-educational-lectures-to-improve-the-diagnosis-of-gastric-lesions
#1
Hitoshi Omura, Naohiro Yoshida, Tomoyuki Hayashi, Kazuhiro Miwa, Hajime Takatori, Hirokazu Tsuji, Katsuhisa Inamura, Yukihiro Shirota, Hiroyuki Aoyagi, Takaharu Masunaga, Kazuyoshi Katayanagi, Hiroshi Kurumaya, Shuichi Kaneko, Hisashi Doyama
BACKGROUND: White globe appearance (WGA) refers to a small white lesion of globular shape underneath cancerous gastric epithelium that can be clearly visualized by magnifying endoscopy with narrowband imaging (M-NBI). WGA has been reported to be a novel endoscopic marker that is highly specific in differentiating early gastric cancer (GC) from low-grade adenoma, and has a significantly higher prevalence in early GCs than in noncancerous lesions. However, interobserver agreement in detecting WGA and whether training intervention can improve diagnostic accuracy are unknown...
December 3, 2016: Gastric Cancer
https://www.readbyqxmd.com/read/27915405/long-term-functional-outcomes-and-knee-alignment-of-computer-assisted-navigated-total-knee-arthroplasty
#2
V Sardana, J M Burzynski, M Khan, N Stone, B S Weening, P K Zalzal
INTRODUCTION: This retrospective study examined the relationship between the mechanical axis throughout a functional arc of motion and functional outcome scores in patients undergoing computer-assisted navigation-based total knee arthroplasty (CAN-TKA) at 6-year follow-up. MATERIALS AND METHODS: The Stryker eNact Precision Knee Navigation System was utilized to obtain pre- and postoperative alignment measurements throughout the functional arc of motion. Patients were contacted via telephone and asked to complete the Short Form-12 and Western Ontario and McMaster Universities, which have been demonstrated to be reliable, valid, and sensitive assessment tools in this patient population...
December 3, 2016: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/27915398/the-interactive-electrode-localization-utility-software-for-automatic-sorting-and-labeling-of-intracranial-subdural-electrodes
#3
Roan A LaPlante, Wei Tang, Noam Peled, Deborah I Vallejo, Mia Borzello, Darin D Dougherty, Emad N Eskandar, Alik S Widge, Sydney S Cash, Steven M Stufflebeam
PURPOSE: Existing methods for sorting, labeling, registering, and across-subject localization of electrodes in intracranial encephalography (iEEG) may involve laborious work requiring manual inspection of radiological images. METHODS: We describe a new open-source software package, the interactive electrode localization utility which presents a full pipeline for the registration, localization, and labeling of iEEG electrodes from CT and MR images. In addition, we describe a method to automatically sort and label electrodes from subdural grids of known geometry...
December 3, 2016: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/27915324/improving-follow-up-of-infants-during-retinopathy-of-prematurity-screening-in-rural-areas
#4
Anand Vinekar, Chaitra Jayadev, Mangat Dogra, Bhujang Shetty
OBJECTIVE: To evaluate the challenges of completing and improving follow-up in an retinopathy of prematurity (ROP) screening program in rural centers. METHODS: Reasons for dropout from a multi-center ROP screening program in rural Karnataka, over two six-month periods, were collected and categorized. Improvement measures introduced between the two periods and its impact was analyzed. RESULTS: Reasons pertaining to travel and logistics (15 of 53, 28...
November 7, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27915316/lack-of-screening-underlies-most-stage-5-retinopathy-of-prematurity-among-cases-presenting-to-a-tertiary-eye-center-in-india
#5
Rajvardhan Azad, Parijat Chandra, Anil Gangwe, Vivek Kumar
OBJECTIVE: To study the barriers to effective screening, early detection and treatment of Retinopathy of Prematurity leading to advanced disease. DESIGN: Cross-sectional study. SETTING: Tertiary eye care hospital in northern India. PARTICIPANTS: 115 babies with bilateral stage 5 ROP identified amongst 354 preterm infants examined over a one year period. METHODS: Information regarding gestational age, birthweight, duration of stay in nursery, duration of supplemental oxygen therapy and treatment details were obtained from discharge summary when available, and by interviewing carers...
November 7, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27915303/candida-species-isolated-from-different-body-sites-and-their-antifungal-susceptibility-pattern-cross-analysis-of-candida-albicans-and-candida-glabrata-biofilms
#6
Valentina Cataldi, Emanuela Di Campli, Paolo Fazii, Tonino Traini, Luigina Cellini, Mara Di Giulio
Candida species are regular commensal in humans, but-especially in immunocompromised patients-they represent opportunistic pathogens giving rise to systemic infection. The aim of the present work was to isolate and characterize for their antifungal profile Candida species from different body sites and to analyze the biofilms produced by C. albicans and C. glabrata isolates. Eighty-one strains of Candida species from 77 patients were identified. Epidemiological study showed that the most isolated species were C...
December 2, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27915266/systematic-ajmaline-challenge-in-patients-with-long-qt-3-syndrome-caused-by-the-most-common-mutation-a-multicentre-study
#7
Stephan Hohmann, Boris Rudic, Torsten Konrad, David Duncker, Thorben König, Erol Tülümen, Thomas Rostock, Martin Borggrefe, Christian Veltmann
AIMS: Overlap syndromes of long QT 3 syndrome (LQT3) and the Brugada syndrome (BrS) have been reported. Identification of patients with an overlapping phenotype is crucial before initiation of Class I antiarrhythmic drugs for LQT3. Aim of the present study was to elucidate the yield of ajmaline challenge in unmasking the Brugada phenotype in patients with LQT3 caused by the most common mutation, SCN5A-E1784K. METHODS AND RESULTS: Consecutive families in tertiary referral centres diagnosed with LQT3 caused by SCN5A-E1784K were included in the study...
December 2, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27915227/prenatal-and-postnatal-polybrominated-diphenyl-ether-exposure-and-visual-spatial-abilities-in-children
#8
Ann M Vuong, Joseph M Braun, Kimberly Yolton, Changchun Xie, Glenys M Webster, Andreas Sjödin, Kim N Dietrich, Bruce P Lanphear, Aimin Chen
Polybrominated diphenyl ethers (PBDEs) are associated with impaired visual spatial abilities in toxicological studies, but no epidemiologic study has investigated PBDEs and visual spatial abilities in children. The Health Outcomes and Measures of the Environment Study, a prospective birth cohort (2003-2006, Cincinnati, OH), was used to examine prenatal and childhood PBDEs and visual spatial abilities in 199 children. PBDEs were measured at 16±3 weeks gestation and at 1, 2, 3, 5, and 8 years using gas chromatography/isotope dilution high-resolution mass spectrometry...
December 1, 2016: Environmental Research
https://www.readbyqxmd.com/read/27915125/artificial-neural-networks-as-a-powerful-numerical-tool-to-classify-specific-features-of-a-tooth-based-on-3d-scan-data
#9
Stefan Raith, Eric Per Vogel, Naeema Anees, Christine Keul, Jan-Frederik Güth, Daniel Edelhoff, Horst Fischer
Chairside manufacturing based on digital image acquisition is gainingincreasing importance in dentistry. For the standardized application of these methods, it is paramount to have highly automated digital workflows that can process acquired 3D image data of dental surfaces. Artificial Neural Networks (ANNs) arenumerical methods primarily used to mimic the complex networks of neural connections in the natural brain. Our hypothesis is that an ANNcan be developed that is capable of classifying dental cusps with sufficient accuracy...
November 27, 2016: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/27915119/neural-correlates-of-pupil-dilation-during-human-fear-learning
#10
Laura Leuchs, Max Schneider, Michael Czisch, Victor I Spoormaker
BACKGROUND: Fear conditioning and extinction are prevailing experimental and etiological models for normal and pathological anxiety. Pupil dilations in response to conditioned stimuli are increasingly used as a robust psychophysiological readout of fear learning, but their neural correlates remain unknown. We aimed at identifying the neural correlates of pupil responses to threat and safety cues during a fear learning task. METHODS: Thirty-four healthy subjects underwent a fear conditioning and extinction paradigm with simultaneous functional magnetic resonance imaging (fMRI) and pupillometry...
December 1, 2016: NeuroImage
https://www.readbyqxmd.com/read/27915115/a-novel-measure-of-reliability-in-diffusion-tensor-imaging-after-data-rejections-due-to-subject-motion
#11
V Sairanen, L Kuusela, O Sipilä, S Savolainen, S Vanhatalo
Diffusion Tensor Imaging (DTI) is commonly challenged by subject motion during data acquisition, which often leads to corrupted image data. Currently used procedure in DTI analysis is to correct or completely reject such data before tensor estimations, however assessing the reliability and accuracy of the estimated tensor in such situations has evaded previous studies. This work aims to define the loss of data accuracy with increasing image rejections, and to define a robust method for assessing reliability of the result at voxel level...
November 30, 2016: NeuroImage
https://www.readbyqxmd.com/read/27915037/quantification-of-pea-enation-mosaic-virus-1-and-2-during-infection-of-pisum-sativum-by-one-step-real-time-rt-pcr
#12
Juliette Doumayrou, Melissa Sheber, Bryony C Bonning, W Allen Miller
Pea enation mosaic virus 1 (PEMV1) and Pea enation mosaic virus 2 (PEMV2) are two viruses in an obligate symbiosis that cause pea enation mosaic disease mainly in plants in the Fabaceae family. This virus system is a valuable model to investigate plant virus replication, movement and vector transmission. Thus, here we describe growth conditions, virus detection methods, and virus accumulation behavior. To measure the accumulation and movement of PEMV1 and PEMV2 in plants during the course of infection, we developed a quantitative real-time one-step reverse transcription PCR procedure using the SYBR-green(®) technology...
November 30, 2016: Journal of Virological Methods
https://www.readbyqxmd.com/read/27914956/individual-refinement-of-attenuation-correction-maps-for-hybrid-pet-mr-based-on-multi-resolution-regional-learning
#13
Kuangyu Shi, Sebastian Fürst, Liang Sun, Mathias Lukas, Nassir Navab, Stefan Förster, Sibylle I Ziegler
PET/MR is an emerging hybrid imaging modality. However, attenuation correction (AC) remains challenging for hybrid PET/MR in generating accurate PET images. Segmentation-based methods on special MR sequences are most widely recommended by vendors. However, their accuracy is usually not high. Individual refinement of available certified attenuation maps may be helpful for further clinical applications. In this study, we proposed a multi-resolution regional learning (MRRL) scheme to utilize the internal consistency of the patient data...
November 19, 2016: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/27914913/vitamin-fortified-snack-food-may-lead-consumers-to-make-poor-dietary-decisions
#14
Linda Verrill, Dallas Wood, Sheryl Cates, Amy Lando, Yuanting Zhang
BACKGROUND: The US Food and Drug Administration's (FDA's) fortification policy discourages the fortification of certain foods, including sugars and snack foods such as cookies, candies, cakes, chips, and carbonated beverages, yet manufacturers sometimes add vitamins and minerals to snack foods. OBJECTIVE: To assess whether vitamin-fortified snack foods affect consumers' information-seeking, purchase decisions, and product-related health perceptions. DESIGN: For this experimental study, participants were randomly assigned to study conditions to compare products that varied in product type, nutrition profile, and fortification and nutrient claim status...
November 30, 2016: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/27914839/late-in-the-bag-intraocular-lens-dislocation-a-randomized-clinical-trial-comparing-lens-repositioning-and-lens-exchange
#15
Olav Kristianslund, Marianne Råen, Atle E Østern, Liv Drolsum
PURPOSE: To compare the efficacy and safety of 2 operation methods for late in-the-bag intraocular lens (IOL) dislocation. DESIGN: Prospective, randomized, parallel-group surgical trial. PARTICIPANTS: Patients referred to Oslo University Hospital (tertiary referral center). METHODS: We randomly assigned 104 patients (104 eyes) either to IOL repositioning by scleral suturing (n = 54) or to IOL exchange with retropupillary fixation of an iris-claw IOL (n = 50)...
November 30, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27914791/aberrant-developmental-titin-splicing-and-dysregulated-sarcomere-length-in-thymosin-%C3%AE-4-knockout-mice
#16
Nicola Smart, Johannes Riegler, Cameron W Turtle, Craig A Lygate, Debra J McAndrew, Katja Gehmlich, Karina N Dubé, Anthony N Price, Vivek Muthurangu, Andrew M Taylor, Mark F Lythgoe, Charles Redwood, Paul R Riley
Sarcomere assembly is a highly orchestrated and dynamic process which adapts, during perinatal development, to accommodate growth of the heart. Sarcomeric components, including titin, undergo an isoform transition to adjust ventricular filling. Many sarcomeric genes have been implicated in congenital cardiomyopathies, such that understanding developmental sarcomere transitions will inform the aetiology and treatment. We sought to determine whether Thymosin β4 (Tβ4), a peptide that regulates the availability of actin monomers for polymerization in non-muscle cells, plays a role in sarcomere assembly during cardiac morphogenesis and influences adult cardiac function...
November 30, 2016: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/27914780/a-monte-carlo-analysis-of-breast-screening-randomized-trials
#17
Luis I Zamora, Cristina Forastero, Damián Guirado, Antonio M Lallena
PURPOSE: To analyze breast screening randomized trials with a Monte Carlo simulation tool. METHODS: A simulation tool previously developed to simulate breast screening programmes was adapted for that purpose. The history of women participating in the trials was simulated, including a model for survival after local treatment of invasive cancers. Distributions of time gained due to screening detection against symptomatic detection and the overall screening sensitivity were used as inputs...
November 30, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27914736/research-progress-of-platelet-transfusion-in-china
#18
REVIEW
Qiushi Wang, Jiangcun Yang, Lori Stevens, Deqing Wang
Platelet products have been increasingly used for more than 50 years. Platelet transfusion is effective for correcting bleeding caused by thrombocytopenia and platelet function defects. In this review, we will outline research on platelet transfusion in China including platelet biosafety, cryopreservation of platelets, the assessment of the effectiveness of platelet transfusion, the causes of platelet transfusion refractoriness including immunization against CD36, and neonatal alloimmune thrombocytopenia.
November 27, 2016: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/27914724/medical-students-understanding-of-oral-and-maxillofacial-surgery-an-irish-perspective
#19
P G C Kielty, B R O'Connor, C J Cotter, A M C Goodson, K F B Payne, A Tahim
Oral and Maxillofacial Surgery (OMFS) remains an enigmatic specialty in Irish medicine and many students are unaware of its scope and the unique career pathway involved. We performed a multicentre cross-sectional study to identify their ability to identify the requirements for entry to specialty training year 3 (ST3) in OMFS, to assess their awareness of OMFS surgeons, and their general awareness of, and exposure to, the specialty. Data were collected through an electronic questionnaire. Participants were asked to select the most suitable surgical specialty to treat a number of common conditions in the head and neck, and to choose the requirements they deemed essential for specialist training...
November 30, 2016: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/27914670/comparison-of-masticatory-efficacy-among-complete-denture-wearers-with-two-adhesives-and-dentate-individuals-a%C3%A2-randomized-crossover-double-blind-clinical-trial
#20
Carlos Torres-Sánchez, Vanessa Montoya-Salazar, Daniel Torres-Lagares, Jose Luis Gutierrez-Pérez, Emilio Jimenez-Castellanos
STATEMENT OF PROBLEM: The masticatory efficacy between dentate and edentulous individuals with and without the use of dental adhesives has been little studied. A comparative study of the addition of various agents of synthetic adhesion (vinyl methyl ether versus polyvinyl acetate) to these adhesives is needed. PURPOSE: The purpose of this randomized, crossover, double-blind clinical trial was to compare the masticatory efficacy of wearers of complete dentures with and without dental adhesives of 2 different compositions and that of dentate controls...
November 30, 2016: Journal of Prosthetic Dentistry
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