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https://www.readbyqxmd.com/read/29131890/modeling-inspiratory-flow-in-a-porcine-lung-airway
#1
Peshala/P Thibotuwawa Gamage, Fardin Khalili, Md/Khurshidul Azad, Hansen/A Mansy
Inspiratory flow in a multi-generation pig lung airways was numerically studied at a steady inlet flow rate of 3.2×10-4 m3/s corresponding to a Reynolds number of 1150 in the trachea. The model was validated by comparing velocity distributions with previous measurements and simulations in simplified airway geometries. Simulation results provided detailed maps of the axial and secondary flow patterns at different cross sections of the airway tree. The vortex core regions in the airways were visualized using absolute helicity values and suggested the presence of secondary flow vortices where two counter rotating vortices were observed at the main bifurcation and in many other bifurcations...
November 13, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29101633/numerical-study-of-dynamic-glottis-and-tidal-breathing-on-respiratory-sounds-in-a-human-upper-airway-model
#2
Jinxiang Xi, Zhaoxuan Wang, Khaled Talaat, Carri Glide-Hurst, Haibo Dong
BACKGROUND: Human snores are caused by vibrating anatomical structures in the upper airway. The glottis is a highly variable structure and a critical organ regulating inhaled flows. However, the effects of the glottis motion on airflow and breathing sound are not well understood, while static glottises have been implemented in most previous in silico studies. The objective of this study is to develop a computational acoustic model of human airways with a dynamic glottis and quantify the effects of glottis motion and tidal breathing on airflow and sound generation...
November 3, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29066290/phenotype-classification-using-the-combination-of-lung-sound-analysis-and-fractional-exhaled-nitric-oxide-for-evaluating-asthma-treatment
#3
Terufumi Shimoda, Yasushi Obase, Yukio Nagasaka, Sadahiro Asai
BACKGROUND: We report the utility of combining lung sound analysis and fractional exhaled nitric oxide (FeNO) for phenotype classification of airway inflammation in patients with bronchial asthma. We investigated the usefulness of the combination of the expiration-to-inspiration sound power ratio in the mid-frequency range (E/I MF) of 200-400 Hz and FeNO for comprehensively classifying disease type and evaluating asthma treatment. METHODS: A total of 233 patients with bronchial asthma were included...
October 21, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29063551/best-paper-selection
#4
(no author information available yet)
Arnold CW, Wallace WD, Chen S, Oh A, Abtin F, Genshaft S, Binder S, Aberle D, Enzmann D. RadPath: A web-based system for integrating and correlating radiology and pathology findings during cancer diagnosis. Acad Radiol 2016 Jan;23(1):90-100 http://escholarship.org/uc/item/22x4021q Hravnak M, Chen L, Dubrawski A, Bose E, Clermont G, Pinsky MR. Real alerts and artifact classification in archived multi-signal vital sign monitoring data: implications for mining big data. J Clin Monit Comput 2016 Dec;30(6):875-88 https://link...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29060920/automated-lung-sound-analysis-for-detecting-pulmonary-abnormalities
#5
Shreyasi Datta, Anirban Dutta Choudhury, Parijat Deshpande, Sakyajit Bhattacharya, Arpan Pal
Identification of pulmonary diseases comprises of accurate auscultation as well as elaborate and expensive pulmonary function tests. Prior arts have shown that pulmonary diseases lead to abnormal lung sounds such as wheezes and crackles. This paper introduces novel spectral and spectrogram features, which are further refined by Maximal Information Coefficient, leading to the classification of healthy and abnormal lung sounds. A balanced lung sound dataset, consisting of publicly available data and data collected with a low-cost in-house digital stethoscope are used...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29060517/respiratory-sounds-classification-using-statistical-biomarker
#6
Ashok Mondal, Hong Tang
In this paper, we have proposed a new feature extraction technique based on statistical morphology of lung sound signal (LS). This work attempts to (i) generate certain intrinsic mode functions (IMFs), (ii) select a set of informative IMFs and (iii) extract relevant features from the selected IMFs and residue. Feature vector is formed by using the higher order moments: mean, standard deviation, skewness and kurtosis and employed as input to the classifier models for classification of three types of LS signals: crackle, wheeze and normal...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29060511/performance-comparison-of-wavelet-based-denoising-methods-on-discontinuous-adventitious-lung-sounds
#7
Sezer Ulukaya, Gorkem Serbes, Yasemin P Kahya
Crackles and their time-domain characteristics provide important clues about different lung diseases. In this paper, we aim to de-noise synthetically produced crackles under various noise levels while preserving their information bearing parts which significantly affect crackle parameters. Classical wavelet based de-noising algorithms are deteriorated by sharp-sudden noise changes and produce Gibbs like fluctuations. On the other hand, total variation based algorithms, which are capable of alleviating the drawbacks of the classical wavelet based algorithms, are failed when dealing with piecewise-smooth signals like crackles and generate unwanted flat regions on the de-noised signals...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29060469/a-multichannel-acoustic-approach-to-define-a-pulmonary-pathology-as-combined-pulmonary-fibrosis-and-emphysema-syndrome
#8
Laura M Santiago-Fuentes, Sonia Charleston-Villalobos, Ramon Gonzalez-Camarena, Mayra Mejia-Avila, Heidegger Mateos-Toledo, Ivette Buendia-Roldan, Tomas Aljama-Corrales
Interstitial lung diseases (ILDs) have been increasing their relevance in loss of lives according to a recent world wide medical information. Idiopathic pulmonary fibrosis (IPF) and combined pulmonary fibrosis and emphysema syndrome (CPFES) belong to ILD class with the latter having a limited survival prognosis. In clinical environment high resolution computed tomography (HRCT) is used to detect CPFE; however, there is still controversy about the amount of emphysema observed in HRCT to declare CPFES. Consequently, to help in the diagnosis of CPFES to develop an alternative technique seems to be attractive...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29060333/detecting-fetal-heart-sounds-by-means-of-fractal-dimension-analysis-in-the-wavelet-domain
#9
E Koutsiana, L J Hadjileontiadis, I Chouvarda, A H Khandoker
Phonocardiography is a low-cost technique for the detection of fetal heart sounds (FHS) that can extend clinical auscultation in mobile and home care setups. The work presented here examines the transferability of a Wavelet Transform (WT)-based method that combines also Fractal Dimension (FD) analysis, previously proposed as WT-FD for the cases of lung and bowel sound analysis [4], to the extraction of FHSs. The WT-FD method has been evaluated with 12 simulated FHS signals and has shown promising results in terms of accuracy and performance (89%) in identifying the location of heartbeat, even in cases of signals with additive noise up to (6dB)...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29055736/participant-selection-for-lung-cancer-screening-by-risk-modelling-the-pan-canadian-early-detection-of-lung-cancer-pancan-study-a-single-arm-prospective-study
#10
Martin C Tammemagi, Heidi Schmidt, Simon Martel, Annette McWilliams, John R Goffin, Michael R Johnston, Garth Nicholas, Alain Tremblay, Rick Bhatia, Geoffrey Liu, Kam Soghrati, Kazuhiro Yasufuku, David M Hwang, Francis Laberge, Michel Gingras, Sergio Pasian, Christian Couture, John R Mayo, Paola V Nasute Fauerbach, Sukhinder Atkar-Khattra, Stuart J Peacock, Sonya Cressman, Diana Ionescu, John C English, Richard J Finley, John Yee, Serge Puksa, Lori Stewart, Scott Tsai, Ehsan Haider, Colm Boylan, Jean-Claude Cutz, Daria Manos, Zhaolin Xu, Glenwood D Goss, Jean M Seely, Kayvan Amjadi, Harmanjatinder S Sekhon, Paul Burrowes, Paul MacEachern, Stefan Urbanski, Don D Sin, Wan C Tan, Natasha B Leighl, Frances A Shepherd, William K Evans, Ming-Sound Tsao, Stephen Lam
BACKGROUND: Results from retrospective studies indicate that selecting individuals for low-dose CT lung cancer screening on the basis of a highly predictive risk model is superior to using criteria similar to those used in the National Lung Screening Trial (NLST; age, pack-year, and smoking quit-time). We designed the Pan-Canadian Early Detection of Lung Cancer (PanCan) study to assess the efficacy of a risk prediction model to select candidates for lung cancer screening, with the aim of determining whether this approach could better detect patients with early, potentially curable, lung cancer...
October 16, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29053400/programmed-death-ligand-1-immunohistochemistry-testing-a-review-of-analytical-assays-and-clinical-implementation-in-non-small-cell-lung-cancer
#11
Reinhard Büttner, John R Gosney, Birgit Guldhammer Skov, Julien Adam, Noriko Motoi, Kenneth J Bloom, Manfred Dietel, John W Longshore, Fernando López-Ríos, Frédérique Penault-Llorca, Giuseppe Viale, Andrew C Wotherspoon, Keith M Kerr, Ming-Sound Tsao
Purpose Three programmed death-1/programmed death-ligand 1 (PD-L1) inhibitors are currently approved for treatment of non-small-cell lung cancer (NSCLC). Treatment with pembrolizumab in NSCLC requires PD-L1 immunohistochemistry (IHC) testing. Nivolumab and atezolizumab are approved without PD-L1 testing, though US Food and Drug Administration-cleared complementary PD-L1 tests are available for both. PD-L1 IHC assays used to assess PD-L1 expression in patients treated with programmed death-1/PD-L1 inhibitors in clinical trials include PD-L1 IHC 28-8 pharmDx (28-8), PD-L1 IHC 22C3 pharmDx (22C3), Ventana PD-L1 SP142 (SP142), and Ventana PD-L1 SP263 (SP263)...
October 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29050231/a-phase-i-study-of-foretinib-plus-erlotinib-in-patients-with-previously-treated-advanced-non-small-cell-lung-cancer-canadian-cancer-trials-group-ind-196
#12
Natasha B Leighl, Ming-Sound Tsao, Geoffrey Liu, Dongsheng Tu, Cheryl Ho, Frances A Shepherd, Nevin Murray, John R Goffin, Garth Nicholas, Shingo Sakashita, Zhuo Chen, Lucia Kim, Jean Powers, Lesley Seymour, Glenwood Goss, Penelope A Bradbury
PURPOSE: MET and AXL mediate resistance to EGFR TKI in NSCLC. Foretinib, a MET/RON/AXL/TIE-2/VEGFR kinase inhibitor may overcome EGFR kinase resistance. This dose escalation study combined foretinib and erlotinib in advanced pretreated NSCLC patients. EXPERIMENTAL DESIGN: The primary endpoint was to define the RP2D of foretinib plus erlotinib as continuous oral daily dosing. Secondary objectives included safety, pharmacokinetics, response and potential biomarkers of response including EGFR, KRAS genotype, MET, AXL expression, and circulating HGF levels...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29033614/fusion-of-lower-limbs-with-severe-urogenital-malformation-in-a-newborn-a-rare-congenital-clinical-syndrome-case-report
#13
Fatemah Al Hadhoud, Abeer H Kamal, Abdulmohsen Al Anjari, Michael Fe Diejomaoh
BACKGROUND: Fused lower limbs combined with severe urogenital malformation, also known as sirenomelia, is a rare congenital clinical syndrome. The etiology is unknown, and the outcome for the affected fetus is rather uncertain. CASE REPORT: Mrs RB, a Kuwaiti woman primigravida, married to a non-consanguineous husband, had uneventful antenatal care in a private health service, until she was admitted to the Maternity Hospital, Kuwait, at 31 weeks of gestation with a 3-hour history of ruptured membranes...
2017: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/29025257/utility-of-the-national-lung-screening-trial-criteria-for-estimation-of-lung-cancer-in-the-korean-population
#14
Ye Jin Lee, Sun Mi Choi, Jinwoo Lee, Chang-Hoon Lee, Sang-Min Lee, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Young Sik Park
Purpose: Screening for lung cancer in high-risk patients using the National Lung Screening Trial (NLST) criteria resulted in a decreased lung cancer-related mortality rate. However, whether these criteria are applicable to the Korean has not been investigated thus far. Therefore, we estimated the utility of the NLST criteria as a screening tool for lung cancer in the Korean population. Materials and Methods: The total number of newly diagnosed lung cancer cases in 2013 was obtained from the Korea National Statistical Office...
October 12, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29019755/interstitial-lung-disease-in-children-made-easier%C3%A2-well-almost
#15
Thomas R Semple, Michael T Ashworth, Catherine M Owens
Interstitial lung disease (ILD) in pediatric patients is different from that in adults, with a vast array of pathologic conditions unique to childhood, varied modes of presentation, and a different range of radiologic appearances. Although rare, childhood ILD (chILD) is associated with significant morbidity and mortality, most notably in conditions of disordered surfactant function, with respiratory failure in 100% of neonates with surfactant protein B dysfunction and 100% mortality without lung transplantation...
October 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28992906/renal-amyloidosis-associated-with-kartagener-syndrome-in-a-dog
#16
Bartolo Celona, Chiara Crinò, Carmelo Bruno, Simona Di Pietro, Elisabetta Giudice
A 4-year-old cocker spaniel, male, of 12kg body weight was presented because of the onset of polyuria or polydipsia. From the first months of its life, the dog had exhibited constant serous to mucopurulent nasal discharge, productive cough, sneezing, reverse sneezing, otitis, and recurrent episodes of fever. The respiratory signs had been treated several times with antibiotics, without ever achieving a complete resolution. Clinical examination revealed normal rectal temperature (38.3°C), increased respiratory rate (40breaths/min), a copious mucous nasal discharge and right deviation of the heart apex beat (ictus cordis)...
June 2017: Topics in Companion Animal Medicine
https://www.readbyqxmd.com/read/28975065/vanishing-lung-syndrome-compound-effect-of-tobacco-and-marijuana-use-on-the-development-of-bullous-lung-disease-a-joint-effort
#17
Shimshon Wiesel, Faraz Siddiqui, Tahir Khan, Sami Hossri, Dany El-Sayegh
Marijuana use has been increasing across the United States due to its legalization as both a medicinal and recreational product. A small number of case reports have described a pathological entity called vanishing lung syndrome (VLS), which is a rare bullous lung disease usually caused by tobacco smoking. Recent case reports have implicated marijuana in the development of VLS. We present a case of a 47-year-old man, who presented to our hospital with shortness of breath, fevers and a productive cough. On physical exam, he was tachypneic with audible stridor and absent right sided breath sounds...
July 31, 2017: Curēus
https://www.readbyqxmd.com/read/28957450/pleiotropy-of-genetic-variants-on-obesity-and-smoking-phenotypes-results-from-the-oncoarray-project-of-the-international-lung-cancer-consortium
#18
Tao Wang, Jee-Young Moon, Yiqun Wu, Christopher I Amos, Rayjean J Hung, Adonina Tardon, Angeline Andrew, Chu Chen, David C Christiani, Demetrios Albanes, Erik H F M van der Heijden, Eric Duell, Gadi Rennert, Gary Goodman, Geoffrey Liu, James D Mckay, Jian-Min Yuan, John K Field, Jonas Manjer, Kjell Grankvist, Lambertus A Kiemeney, Loic Le Marchand, M Dawn Teare, Matthew B Schabath, Mattias Johansson, Melinda C Aldrich, Michael Davies, Mikael Johansson, Ming-Sound Tsao, Neil Caporaso, Philip Lazarus, Stephen Lam, Stig E Bojesen, Susanne Arnold, Xifeng Wu, Xuchen Zong, Yun-Chul Hong, Gloria Y F Ho
Obesity and cigarette smoking are correlated through complex relationships. Common genetic causes may contribute to these correlations. In this study, we selected 241 loci potentially associated with body mass index (BMI) based on the Genetic Investigation of ANthropometric Traits (GIANT) consortium data and calculated a BMI genetic risk score (BMI-GRS) for 17,037 individuals of European descent from the Oncoarray Project of the International Lung Cancer Consortium (ILCCO). Smokers had a significantly higher BMI-GRS than never-smokers (p = 0...
2017: PloS One
https://www.readbyqxmd.com/read/28944222/fetal-heart-sounds-detection-using-wavelet-transform-and-fractal-dimension
#19
Elisavet Koutsiana, Leontios J Hadjileontiadis, Ioanna Chouvarda, Ahsan H Khandoker
Phonocardiography is a non-invasive technique for the detection of fetal heart sounds (fHSs). In this study, analysis of fetal phonocardiograph (fPCG) signals, in order to achieve fetal heartbeat segmentation, is proposed. The proposed approach (namely WT-FD) is a wavelet transform (WT)-based method that combines fractal dimension (FD) analysis in the WT domain for the extraction of fHSs from the underlying noise. Its adoption in this field stems from its successful use in the fields of lung and bowel sounds de-noising analysis...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28932613/primary-pulmonary-lymphoma-presenting-with-superior-vena-cava-syndrome-in-a-young-female
#20
Divya Salhan, Prakash Verma, Tun Win Naing, Ebad Ur Rehman, Saroj Kandel, Danillo Enriquez, Joseph Quist, Frances Schmidt
Primary Pulmonary Diffuse Large B Cell Lymphoma (PPDLBCL) is an extremely rare entity, which exhibits an aggressive behavior by compressing local blood vessels. It represents only 0.04% of all lymphoma cases and is extremely rare in young age. We present a case of a primary pulmonary lymphoma with superior vena cava syndrome (SVCS) in a young female. 27-year-old African American female presented with fever, cough, and facial puffiness for 2 weeks and unintentional weight loss. Chest examination showed decreased breath sounds and dullness on percussion on right side...
2017: Case Reports in Pulmonology
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