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https://www.readbyqxmd.com/read/29735562/impact-of-clofazimine-dosing-on-treatment-shortening-of-the-first-line-regimen-in-a-mouse-model-of-tuberculosis
#1
Nicole C Ammerman, Rosemary V Swanson, Elaine M Bautista, Deepak V Almeida, Vikram Saini, Till F Omansen, Haidan Guo, Yong Seok Chang, Si-Yang Li, Asa Tapley, Rokeya Tasneen, Sandeep Tyagi, Fabrice Betoudji, Chivonne Moodley, Bongani Ngcobo, Logan Pillay, Linda A Bester, Sanil D Singh, Richard E Chaisson, Eric Nuermberger, Jacques H Grosset
The anti-leprosy drug clofazimine was recently repurposed as part of a newly endorsed short-course regimen for multidrug-resistant tuberculosis. It also enables significant treatment-shortening when added to the first-line regimen for drug-susceptible tuberculosis in a mouse model. However, clofazimine causes dose- and duration-dependent skin discoloration in patients, and the optimal clofazimine dosing strategy in the context of the first-line regimen is unknown. We utilized a well-established mouse model to systematically address the impact of duration, dose, and companion drugs on the treatment-shortening activity of clofazimine in the first-line regimen...
May 7, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29732350/a-new-stethoscope-design-with-unique-characteristics-and-development-in-medical-device
#2
M Ghahramanifar, M Haghani, A Ghadimi Moghadam, A K Ghadimi Moghadam
As regards the significant role of stethoscopes in the diagnosis of congenital and adventitious heart diseases and prevention of irreparable complications of these diseases, the quality of hearing sound of these stethoscopes by a physician has a significant impact on the disease diagnosis. This device plays an important role in the early diagnosis of congenital heart and respiratory diseases and provides this feasibility since birth. Also, the importance of this device performance in the diagnosis of heart, cardiovascular and respiratory diseases at different age periods is not a secret...
March 2018: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/29724454/the-eighth-tnm-classification-for-lung-cancer-what-is-next
#3
EDITORIAL
Ming-Sound Tsao, Ju-Yoon Yoon
No abstract text is available yet for this article.
April 25, 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29724435/lung-sounds-classification-using-convolutional-neural-networks
#4
Dalal Bardou, Kun Zhang, Sayed Mohammad Ahmad
Lung sounds convey relevant information related to pulmonary disorders, and to evaluate patients with pulmonary conditions, the physician or the doctor uses the traditional auscultation technique. However, this technique suffers from limitations. For example, if the physician is not well trained, this may lead to a wrong diagnosis. Moreover, lung sounds are non-stationary, complicating the tasks of analysis, recognition, and distinction. This is why developing automatic recognition systems can help to deal with these limitations...
May 1, 2018: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/29724394/enhancing-our-understanding-of-computerised-adventitious-respiratory-sounds-in-different-copd-phases-and-healthy-people
#5
Ana Oliveira, João Rodrigues, Alda Marques
BACKGROUND: Timely diagnosis of acute exacerbations of COPD (AECOPD) is challenging as it depends on patients' reports. AECOPD are characterised by increased airway obstruction, mucus and air trapping, which results in changes in lung acoustics. Thus, adventitious respiratory sounds (ARS) may be useful to detect/monitor AECOPD. OBJECTIVE: To evaluate computerised ARS changes during AECOPD. METHODS: 25 non-hospitalised patients with AECOPD (16♂, 70 [62...
May 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29717676/lung-and-heart-sounds-analysis-state-of-the-art-and-future-trends
#6
Ana L Padilla-Ortiz, David Ibarra
Lung sounds, which include all sounds that are produced during the mechanism of respiration, may be classified into normal breath sounds and adventitious sounds. Normal breath sounds occur when no respiratory problems exist, whereas adventitious lung sounds (wheeze, rhonchi, crackle, etc.) are usually associated with certain pulmonary pathologies. Heart and lung sounds that are heard using a stethoscope are the result of mechanical interactions that indicate operation of cardiac and respiratory systems, respectively...
2018: Critical Reviews in Biomedical Engineering
https://www.readbyqxmd.com/read/29697011/influence-of-the-vibralung-acoustical-percussor-on-pulmonary-function-and-sputum-expectoration-in-individuals-with-cystic-fibrosis
#7
Courtney M Wheatley, Sarah E Baker, Cori M Daines, Hanna Phan, Marina G Martinez, Wayne J Morgan, Eric M Snyder
BACKGROUND: The Vibralung Acoustical Percussor is a new airway clearance therapy (ACT) utilizing intrapulmonary sound waves in addition to positive expiratory pressure (PEP). We evaluated the safety of the Vibralung and collected preliminary data on its ability to mediate sputum expectoration in individuals with cystic fibrosis (CF). METHODS: Over two separate studies, 10 and 11 mild to moderate CF patients were recruited for study I and II, respectively. Study I: Vibralung was used for 20 min with either no sound (NS: PEP only) or sound (S: PEP and sound) on randomized visits...
January 2018: Therapeutic Advances in Respiratory Disease
https://www.readbyqxmd.com/read/29674395/bilateral-tension-pneumothorax-after-acupuncture
#8
Nurashikin Mohammad
Acupuncture is an ancient complementary medicine which is currently used worldwide. Many serious adverse events have been reported which include a spectrum of mild-to-fatal complications. However, the level of awareness with regard to complications is still low both to physicians and patients. We report a 63-year-old who presented with acute shortness of breath 2 hours after having had acupuncture. On examination, there was absent breath sound heard on the left lung and slightly reduced breath sound on the right lung...
April 19, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29674377/sensitive-high-frequency-hearing-in-earless-and-partially-eared-harlequin-frogs-atelopus
#9
Molly C Womack, Jakob Christensen-Dalsgaard, Luis A Coloma, Kim L Hoke
Harlequin frogs, genus Atelopus , communicate at high frequencies despite most species lacking a complete tympanic middle ear that facilitates high frequency hearing in most anurans and other tetrapods. Here we test whether Atelopus are better at sensing high frequency acoustic sound compared to other eared and earless species in the Bufonidae family, determine whether middle ear variation within Atelopus affects hearing sensitivity, and test potential hearing mechanisms in Atelopus We determine that at high frequencies (2000-4000 Hz) Atelopus are 10-34 dB more sensitive than other earless bufonids but are relatively insensitive to mid-range frequencies (900-1500 Hz) compared to eared bufonids...
April 19, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29662309/description-of-nighttime-cough-epochs-in-patients-with-stable-copd-gold-ii-iv
#10
Patrick Fischer, Volker Gross, Johannes Kroenig, Andreas Weissflog, Olaf Hildebrandt, Keywan Sohrabi, Ulrich Koehler
Purpose: Chronic cough is one of the main symptoms of COPD. Ambulatory objective monitoring provides novel insights into the determinants and characteristics of nighttime cough in COPD. Materials and methods: Nighttime cough was monitored objectively by LEOSound lung sound monitor in patients with stable COPD II-IV. In 30 patients, with 10 patients in each stage group, nighttime cough was analyzed for epoch frequency, epoch severity (epoch length and coughs per epoch), and pattern (productive or nonproductive)...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29661164/helicase-like-transcription-factor-expression-is-associated-with-a-poor-prognosis-in-non-small-cell-lung-cancer-nsclc
#11
Ludovic Dhont, Melania Pintilie, Ethan Kaufman, Roya Navab, Shirley Tam, Arsène Burny, Frances Shepherd, Alexandra Belayew, Ming-Sound Tsao, Céline Mascaux
BACKGROUND: The relapse rate in early stage non-small cell lung cancer (NSCLC) after surgical resection is high. Prognostic biomarkers may help identify patients who may benefit from additional therapy. The Helicase-like Transcription Factor (HLTF) is a tumor suppressor, altered in cancer either by gene hypermethylation or mRNA alternative splicing. This study assessed the expression and the clinical relevance of wild-type (WT) and variant forms of HLTF RNAs in NSCLC. METHODS: We analyzed online databases (TCGA, COSMIC) for HLTF alterations in NSCLC and assessed WT and spliced HLTF mRNAs expression by RT-ddPCR in 39 lung cancer cell lines and 171 patients with resected stage I-II NSCLC...
April 16, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29650313/a-novel-feature-extraction-technique-for-pulmonary-sound-analysis-based-on-emd
#12
Ashok Mondal, Poulami Banerjee, Hong Tang
BACKGROUND AND OBJECTIVE: The stethoscope based auscultation technique is a primary diagnostic tool for chest sound analysis. However, the performance of this method is limited due to its dependency on physicians experience, knowledge and also clarity of the signal. To overcome this problem we need an automated computer-aided diagnostic system that will be competent in noisy environment. In this paper, a novel feature extraction technique is introduced for discriminating various pulmonary dysfunctions in an automated way based on pattern recognition algorithms...
June 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29650306/multichannel-lung-sound-analysis-for-asthma-detection
#13
Md Ariful Islam, Irin Bandyopadhyaya, Parthasarathi Bhattacharyya, Goutam Saha
BACKGROUND AND OBJECTIVE: Lung sound signals convey valuable information of the lung status. Auscultation is an effective technique to appreciate the condition of the respiratory system using lung sound signals. The prior works on asthma detection from lung sound signals rely on the presence of wheeze. In this paper, we have classified normal and asthmatic subjects using advanced signal processing of posterior lung sound signals, even in the absence of wheeze. METHODS: We collected lung sounds of 60 subjects (30 normal and 30 asthma) using a novel 4-channel data acquisition system from four different positions over the posterior chest, as suggested by the pulmonologist...
June 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29643543/-airway-foreign-body-caused-by-aspiration-of-artificial-nasal-sponge-a-case-report
#14
T X Fu, X Wang, M L Liu
57-year-old male was admitted to hospital for severe headache and seizure attacks on November 6th, 2016. After radiology and spinal fluid examination, he was diagnosed with viral encephalitis and treated with antiviral medicine, antibiotics and mannitol, but he was in sustained unconsciousness and weak in expectorating. The patient was given oxygen through artificial nasal after bedside tracheotomy. At 1:00 am on January 12th, 2016, there was a sudden drop in blood pressure, heart rate and oxygen saturation with left lung breath sounds slightly lower than the other side...
April 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29618678/the-acute-effect-of-exposure-to-noise-on-cardiovascular-parameters-in-young-adults
#15
Shih-Yi Lu, Cheng-Lung Lee, Kuei-Yi Lin, Yen-Hui Lin
OBJECTIVE: In this study, an experiment was conducted to examine whether noise exposure produced acute changes in cardiovascular responses, and whether these responses differed based on psycho-acoustic parameters to noises of low to high intensity. METHODS: Thirty healthy subjects were enrolled. Three industrial noises were binaurally presented with a supra-aural earphone. The sound levels of noise were <55, 75, and 90 dB. Each noise was continued for 20 min and the electrocardiogram was simultaneously recorded...
April 4, 2018: Journal of Occupational Health
https://www.readbyqxmd.com/read/29614795/full-atrioventricular-block-secondary-to-acute-poisoning-mercury-a-case-report
#16
Amelia Geraldine Peregrina-Chávez, María Del Rayo Ramírez-Galindo, Rolando Chávez-Martínez, Cesar Anuar Delahanty-Delgado, Fernando Vazquez-Alaniz
Background: The biological behaviour and clinical significance of mercury toxicity vary according to its chemical structure. Mercury differs in its degree of toxicity and in its effects on the nervous, digestive and immune systems as well as on organs such as the lungs, kidneys, skin, eyes and heart. Human exposure occurs mainly through inhalation of elemental mercury vapours during industrial and artisanal processes such as artisanal and small-scale gold mining. Case presentation: A 52-years-old female, housewife, with a body mass index of 25...
April 2, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29606266/-pulmonary-ultrasound-and-dialysis
#17
Alexandre Seidowsky, Ève Vilaine, Nicolas Mansencal, Alexandre Ébel, Cédric Villain, Lynda Cheddani, Ziad A Massy
Profound deficit of the body fluid composition regulation system is present at the end stage kidney disease, leading to the increase the risk of acute or chronic volume overload, which impacts the morbidity and mortality in these patients. Pulmonary ultrasound by its ability to estimate extrapulmonary water at an infraclinical stage has helped to make progress in this area. Line B is the element of fundamental semiology that reflects the presence of water in the pulmonary alveoli. The alteration of left ventricular function and the increase of pulmonary capillary permeability are the determining factors in the genesis of subclinical pulmonary congestion and are positively correlated with B-lines...
April 2018: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29604685/localization-of-adventitious-respiratory-sounds
#18
Brian Henry, Thomas J Royston
In a recent publication by Henry and Royston [J. Acoust. Soc. Am. 142, 1774-1783 (2017)], an algorithm was introduced to calculate the acoustic response to externally introduced and endogenous respiratory sounds within a realistic, patient-specific subglottal airway tree. This work is extended using an efficient numerical boundary element (BE) approach to calculate the resulting radiated sound field from the airway tree into the lung parenchyma taking into account the surrounding chest wall. Within the BE model of the left lung parenchyma, comprised of more than 6000 triangular surface elements, more than 30 000 monopoles are used to approximate complex airway-originated acoustic sources...
March 2018: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29600103/report-of-a-lung-carcinoma-extended-to-the-left-atrium-through-pulmonary-vein
#19
Federico Cipriano, Lycio U Dessoti, Alfredo José Rodrigues, Walter Vilella de Andrade Vicente, Fernando Chahud, Paulo Roberto B Evora
Lung cancers may extend along or grow through the pulmonary veins to invade or lie within the left atrium (LA). A 62-year-old man, previously healthy, presented with 1-month ventilatory-independent right hemithorax back pain, dry cough and large effort dyspnea. He also referred weight loss of 12 kg in 10 months and denied hemoptysis. As antecedents, he smoked for 40 years and moderate daily alcoholism. On physical examination, the patient was in good general condition, hydrated and regular respiration at rest [blood pressure (BP) =120/80 mmHg; heart rate (HR) =90 bpm; respiratory rate (RR) =16 rpm]...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29566438/ren%C3%A3-laennec-and-the-origins-of-the-stethoscope
#20
Göran Wennergren
Although more than 200 years have passed since the stethoscope was invented, auscultation of the lungs is still a cornerstone in the diagnostics of asthma and other lung disorders. It is gratifying that the importance of good skills in auscultation of respiratory sounds is highlighted in a Different View article by Korppi and Lauhkonen in this issue of Acta Paediatrica (1).The stethoscope was invented in 1816 by René Théophile Hyacinthe Laennec (1781-1826), while he was a physician at l'Hôpital Necker in Paris (Figure 1) (2)...
March 22, 2018: Acta Paediatrica
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