keyword
https://read.qxmd.com/read/38490138/impulse-oscillometry-in-patients-with-pulmonary-arterial-hypertension-an-exploratory-study
#1
JOURNAL ARTICLE
Helena Jannuzzi Villas Bôas, Ilma Aparecida Paschoal, Mônica Corso Pereira
INTRODUCTION: Studies suggest peripheral airway abnormalities in Pulmonary Arterial Hypertension (PAH). Impulse Oscillometry (IOS) is a noninvasive and sensitive technique for assessing the small airways. It evaluates the impedance of the respiratory system ‒ Resistance (R) and reactance (X) ‒ to a pulse of sound waves sent to the lungs, in a range of frequencies (5‒20 Hz). METHOD: Resistance variables: R5, R20, R5-R20 and reactance variables: AX (reactance area) and Fres (resonance frequency)...
March 14, 2024: Clinics
https://read.qxmd.com/read/38478596/poor-in-hospital-congestion-improvement-in-acute-heart-failure-patients-classified-according-to-lvef-prognostic-implications
#2
JOURNAL ARTICLE
Gaetano Ruocco, Nicolas Girerd, Tripti Rastogi, Zohra Lamiral, Alberto Palazzuoli
BACKGROUND: Residual congestion in acute heart failure (AHF) is associated with poor prognosis. However, there is a lack of data on the prognostic value of changes in a combined assessment of in-hospital congestion. The present study sought to assess the association between in-hospital congestion changes and subsequent prognosis according to left ventricular ejection fraction (LVEF) classification. METHODS: Patients (N=244, 80.3±7.6 years, 50.8% male) admitted for acute HF in two European tertiary care centers underwent clinical assessment (congestion score included dyspnea at rest, rales, third heart sound, jugular venous distention, peripheral edema and hepatomegaly; simplified congestion score included rales and peripheral edema), echocardiography, lung ultrasound (LUS) and natriuretic peptides (NP) measurement at admission and discharge...
March 13, 2024: European Heart Journal Cardiovascular Imaging
https://read.qxmd.com/read/38470893/multi-modal-deep-learning-methods-for-classification-of-chest-diseases-using-different-medical-imaging-and-cough-sounds
#3
JOURNAL ARTICLE
Hassaan Malik, Tayyaba Anees
Chest disease refers to a wide range of conditions affecting the lungs, such as COVID-19, lung cancer (LC), consolidation lung (COL), and many more. When diagnosing chest disorders medical professionals may be thrown off by the overlapping symptoms (such as fever, cough, sore throat, etc.). Additionally, researchers and medical professionals make use of chest X-rays (CXR), cough sounds, and computed tomography (CT) scans to diagnose chest disorders. The present study aims to classify the nine different conditions of chest disorders, including COVID-19, LC, COL, atelectasis (ATE), tuberculosis (TB), pneumothorax (PNEUTH), edema (EDE), pneumonia (PNEU)...
2024: PloS One
https://read.qxmd.com/read/38469455/artificial-intelligence-based-framework-to-identify-the-abnormalities-in-the-covid-19-disease-and-other-common-respiratory-diseases-from-digital-stethoscope-data-using-deep-cnn
#4
JOURNAL ARTICLE
Kranthi Kumar Lella, M S Jagadeesh, P J A Alphonse
The utilization of lung sounds to diagnose lung diseases using respiratory sound features has significantly increased in the past few years. The Digital Stethoscope data has been examined extensively by medical researchers and technical scientists to diagnose the symptoms of respiratory diseases. Artificial intelligence-based approaches are applied in the real universe to distinguish respiratory disease signs from human pulmonary auscultation sounds. The Deep CNN model is implemented with combined multi-feature channels (Modified MFCC, Log Mel, and Soft Mel) to obtain the sound parameters from lung-based Digital Stethoscope data...
December 2024: Health Information Science and Systems
https://read.qxmd.com/read/38452443/invalidity-of-jrs-atypical-pneumonia-prediction-score-in-omicron-variant-of-covid-19-pneumonia
#5
JOURNAL ARTICLE
Naoyuki Miyashita, Yasushi Nakamori, Makoto Ogata, Naoki Fukuda, Akihisa Yamura, Yoshihisa Ishiura, Tomoki Ito
BACKGROUND: We evaluated whether the Japanese Respiratory Society (JRS) atypical pneumonia prediction score can be adapted for the diagnosis of COVID-19 pneumonia due to Omicron BA.1, BA.2, and BA.5 subvariants. METHODS: We enrolled a total of 547 patients with community-acquired COVID-19 pneumonia. Of the COVID-19 pneumonia patients, 198 cases were the Omicron BA.1 subvariant, 127 cases were the Omicron BA.2 subvariant, and 222 cases were the Omicron BA.5 subvariant...
March 6, 2024: Respiratory Investigation
https://read.qxmd.com/read/38450738/evolution-of-air-borne-vocalization-insights-from-neural-studies-in-the-archeobatrachian-species-bombina-orientalis
#6
JOURNAL ARTICLE
Stefan Huggenberger, Wolfgang Walkowiak
Vocalization of tetrapods evolved as an air-driven mechanism. Thus, it is conceivable that the underlaying neural network might have evolved from more ancient respiratory circuits and be made up of homologous components that generate breathing rhythms across vertebrates. In this context, the extant species of stem anurans provide an opportunity to analyze the connection of the neural circuits of lung ventilation and vocalization. Here, we analyzed the fictive lung ventilation and vocalization behavior of isolated brains of the Chinese fire-bellied toad Bombina orientalis during their mating season by nerve root recordings...
March 2024: Journal of Comparative Neurology
https://read.qxmd.com/read/38449942/acute-cholecystitis-caused-by-campylobacter-jejuni-mimicking-acute-coronary-syndrome
#7
Hiroki Uehara, Yutaro Oe, Takaki Yoshimura, Takahiro Gunji, Masaki Okuyama
Campylobacter spp. is a widely recognized pathogen accountable for acute enteritis, frequently linked to sepsis, primarily attributed to C. jejuni. Instances of Campylobacter-induced cholecystitis are infrequent, with only a limited number of documented case reports. Acute cholecystitis has been sporadically documented to induce electrocardiographic alterations, occasionally simulating an acute coronary syndrome (ACS). Herein, we present an instance of cholecystitis induced by C. jejuni, posing a challenge in its differentiation from ACS due to electrocardiographic modifications...
February 2024: Curēus
https://read.qxmd.com/read/38435183/the-impact-of-respiratory-function-training-and-rehabilitation-nursing-on-the-recovery-of-patients-with-mycoplasma-pneumoniae-pneumonia
#8
JOURNAL ARTICLE
Humayun Saleem, Sarosh Khan Jadoon, Amna Akbar, Nisha Hamid Awan, Emama Arshad Abbasi, Javeria Qadeer Abbasi, Soffia Khursheed, Jhanzeb Ahmed, Mohammad Saleem Khan, Sabahat Tasneem
Introduction The goal of this study was to see how people who had been diagnosed with Mycoplasma pneumoniae pneumonia (MPP) responded to respiratory function training and rehabilitation (RFTR) nursing. Methodology A total of 122 patients (five to 12 years of age) diagnosed with Mycoplasma pneumoniae pneumonia (MPP) and refractory Mycoplasma pneumoniae pneumonia (RMPP) using enzyme-linked immunoassay and PCR were included in this study. These patients were hospitalized at a tertiary care hospital from February 2022 to December 2022...
February 2024: Curēus
https://read.qxmd.com/read/38430167/comparative-safety-assessment-of-high-and-low-doses-of-anlotinib-in-combination-with-pd-1-monoclonal-antibody-for-advanced-non-small-cell-lung-cancer-patients
#9
JOURNAL ARTICLE
Lin Wan, Yan Xu, Liqiong Liu, Hui Huang
BACKGROUND: The advent of immunotherapy has revolutionized non-small cell lung cancer (NSCLC) treatment. Anlotinib (AN), a multitargeted tyrosine kinase inhibitor, holds promise in combination with PD-1 monoclonal antibody therapy. Understanding the impact of optimal dosage is pivotal. OBJECTIVE: This study aims to assess the comparative efficacy of high-dose AN versus low-dose AN when combined with PD-1 monoclonal antibody for the treatment of NSCLC. METHODS: A total of 70 patients with NSCLC undergoing PD-1 monoclonal antibody therapy at our hospital from June 2020 to January 2022 were selected...
March 1, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38420389/lung-disease-recognition-methods-using-audio-based-analysis-with-machine-learning
#10
REVIEW
Ahmad H Sabry, Omar I Dallal Bashi, N H Nik Ali, Yasir Mahmood Al Kubaisi
The use of computer-based automated approaches and improvements in lung sound recording techniques have made lung sound-based diagnostics even better and devoid of subjectivity errors. Using a computer to evaluate lung sound features more thoroughly with the use of analyzing changes in lung sound behavior, recording measurements, suppressing the presence of noise contaminations, and graphical representations are all made possible by computer-based lung sound analysis. This paper starts with a discussion of the need for this research area, providing an overview of the field and the motivations behind it...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38392336/central-autonomic-mechanisms-involved-in-the-control-of-laryngeal-activity-and-vocalization
#11
REVIEW
Marta González-García, Laura Carrillo-Franco, Carmen Morales-Luque, Marc Stefan Dawid-Milner, Manuel Víctor López-González
In humans, speech is a complex process that requires the coordinated involvement of various components of the phonatory system, which are monitored by the central nervous system. The larynx in particular plays a crucial role, as it enables the vocal folds to meet and converts the exhaled air from our lungs into audible sounds. Voice production requires precise and sustained exhalation, which generates an air pressure/flow that creates the pressure in the glottis required for voice production. Voluntary vocal production begins in the laryngeal motor cortex (LMC), a structure found in all mammals, although the specific location in the cortex varies in humans...
February 13, 2024: Biology
https://read.qxmd.com/read/38361358/a-green-surprise-bilateral-bilious-pleural-effusion-secondary-to-esophageal-rupture-a-case-report
#12
JOURNAL ARTICLE
Diviya Bharathi Ravikumar, Barath Prashanth Sivasubramanian, Francis Vino Dominic Savio, Tharajan Gunendran, Saketh Palasamudram Shekar
Bilothorax, an exudative pleural effusion due to the accumulation of bile. It is also called cholethorax or thoracobilia and was initially reported in 1971. Here, we report a rare case of an elderly male presenting with bilateral bilothorax due to esophageal rupture. A 78-year-old man with multiple medical ailments presented to the emergency room (ER) with a severe episode of vomiting accompanied by a popping sound, respiratory distress, and right sided chest pain. The patient had tachycardia, BP of 101/89 mm Hg, and tachypnea...
2024: Journal of Investigative Medicine High Impact Case Reports
https://read.qxmd.com/read/38339818/meta-analysis-on-the-impact-of-immune-senescence-unravelling-the-interplay-in-cutaneous-wound-healing-and-lung-cancer-progression
#13
REVIEW
Mengqian Dong, Ying Jin, Xiaoyang Lin, Shuangshuang Wang, Peihong Shen
The primary objective of this meta-analysis was to provide the comprehensive understanding of the intricate correlation that existed between immune senescence and its effects on the advancement of lung cancer as well as recovery of cutaneous wounds. By conducting this systematic review of six rigorous studies utilizing databases such as PubMed and Web of Science, this research examined the multitude of facets pertaining to immune aging and consequences it bear on the health outcomes. The incorporated studies encompassed wide range of geographical and methodological viewpoints, with the specific emphasis on non-small-cell lung cancer and diverse scenarios related to wound recovery...
February 2024: International Wound Journal
https://read.qxmd.com/read/38333307/assessment-of-performance-and-confidence-level-of-simulation-based-clinical-examination-of-respiratory-system-in-undergraduate-medical-students-of-a-medical-college-a-comparative-cross-sectional-study
#14
JOURNAL ARTICLE
Yesha Shree Rajaure, Bikalp Thapa, Lee Budhathoki, Shavana R L Rana, Rajendra Neupane, Parag Karki
INTRODUCTION: Students in the preclinical phase have adequate clinical exposure to normal physiological findings of clinical examinations performed in healthy peers but do not have exposure to pathological findings other than theoretical knowledge, which is challenging for students during the clinical phase of curricula in examining actual patients. Simulation based medical education (SBME) has recently emerged to address this gap. This study aimed to assess performance and confidence level of simulation based clinical examination of respiratory system in preclinical undergraduate medical students of a medical college...
February 2024: Annals of Medicine and Surgery
https://read.qxmd.com/read/38320860/a-comparative-study-to-confirm-the-endotracheal-tube-placement-using-ultrasonography-and-standard-auscultation-method-in-children
#15
JOURNAL ARTICLE
Neha Sinha, Nandita Kad, Mayuri Golhar, Disha Gupta, Anshul Anshul, Prakriti Bishnoi
BACKGROUND: In pediatric patients due to shorter trachea suboptimal positioning of endotracheal tube (ETT) is seen in 20%-50% of patients triggering grave complications. We compared standard auscultation and ultrasound-guided lung sliding to confirm the position of ETT in children. METHODS: Seventy-five pediatric patients between 2-8 years of age, American Society of Anesthesiologists physical status classification I and II scheduled for surgery under general anesthesia with endotracheal intubation were studied...
September 1, 2023: Asian Journal of Anesthesiology
https://read.qxmd.com/read/38316234/drug-solubility-in-biorelevant-media-in-the-context-of-an-inhalation-based-biopharmaceutics-classification-system-ibcs
#16
JOURNAL ARTICLE
Andreea Floroiu, Brigitta Loretz, Johannes Krämer, Claus-Michael Lehr
An inhalation-based Biopharmaceutical Classification System for pulmonary drugs (iBCS) holds the perspective to allow for scientifically sound prediction of differences in the in vivo performance of orally inhaled drug products (OIDPs). A set of nine drug substances were selected, that are administered via both the oral and pulmonary routes. Their solubility was determined in media representative for the oral (Fasted State Simulated Intestinal Fluid (FaSSIF)) and pulmonary (Alveofact medium and Simulated Lung Fluid (SLF)) routes of administration to confirm the need for a novel approach for inhaled drugs...
February 3, 2024: European Journal of Pharmaceutics and Biopharmaceutics
https://read.qxmd.com/read/38309959/-standard-technical-specifications-for-methacholine-chloride-methacholine-bronchial-challenge-test-2023
#17
JOURNAL ARTICLE
(no author information available yet)
The methacholine challenge test (MCT) is a standard evaluation method of assessing airway hyperresponsiveness (AHR) and its severity, and has significant clinical value in the diagnosis and treatment of bronchial asthma. A consensus working group consisting of experts from the Pulmonary Function and Clinical Respiratory Physiology Committee of the Chinese Association of Chest Physicians, the Task Force for Pulmonary Function of the Chinese Thoracic Society, and the Pulmonary Function Group of Respiratory Branch of the Chinese Geriatric Society jointly developed this consensus...
February 12, 2024: Chinese Journal of Tuberculosis and Respiratory Diseases
https://read.qxmd.com/read/38309936/temporal-association-between-vaping-and-risk-of-cardiac-events
#18
JOURNAL ARTICLE
Sahej Bains, Ramin Garmany, Raquel Neves, John R Giudicessi, Xiaozhi Gao, David J Tester, J Martijn Bos, Michael J Ackerman
OBJECTIVE: To describe our early observations with sudden cardiac arrest (SCA) and sudden death (SD) in patients using vape products. PATIENTS AND METHODS: A retrospective analysis of Mayo Clinic's Windland Smith Rice Genetic Heart Rhythm Clinic and Sudden Death Genomics Laboratory was performed on all SCA survivors and decedents who presented between January 1, 2007, and December 31, 2021, to identify patients/decedents with a history of vaping. Data abstraction included patient demographics, clinical characteristics, and documented use of vape products...
February 2024: Mayo Clinic Proceedings
https://read.qxmd.com/read/38295417/case-report-pericardial-actinomycosis-in-a-79-year-old-man-with-poor-dental-hygiene
#19
Chun-Hsun Liao, Tzong-Yow Wu, Yen-Liang Lin, Wang-Da Liu, Jann-Tay Wang, Jin-Shing Chen, Yi-Lwun Ho
Actinomycosis is an uncommon infection caused by Actinomyces species, and the diagnosis is often challenging owing to low prevalence and diverse clinical manifestations. Pericardial involvement of actinomycosis is particularly rare. Here, we present a case of a 79-year-old man who initially complained of exertional dyspnea, orthopnea, and decreased urine amount. There was no fever, chest pain, or productive cough. Physical examination was remarkable for decreased breath sounds at the left lower lung field. Poor dental hygiene and a firm, well-defined mass without discharge over the hard palate were noted...
January 30, 2024: American Journal of Tropical Medicine and Hygiene
https://read.qxmd.com/read/38292413/the-perceived-value-of-liquid-biopsy-results-from-a-canadian-validation-study-of-circulating-tumor-dna-t790m-testing-patient-s-willingness-to-pay-a-brief-report
#20
JOURNAL ARTICLE
Kaitlin H Chen, Tristan A Barnes, Janessa Laskin, Parneet Cheema, Geoffrey Liu, Mussawar Iqbal, Jeffrey Rothenstein, Ronald Burkes, Ming-Sound Tsao, Natasha B Leighl
INTRODUCTION: Liquid biopsy is recommended to diagnose molecular resistance to targeted therapy in patients with lung cancer. Nevertheless, not all jurisdictions provide funding and patient access. We report patients' perceived value of liquid biopsy in targeted therapy resistance. METHODS: Canadian patients participating in a national EGFR T790M liquid biopsy validation study completed structured interviews measuring perceived value and willingness-to-pay for plasma circulating tumor DNA testing as an alternative to tumor biopsy using open-ended and iterative bidding approaches...
January 2024: JTO clinical and research reports
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