Sandeep Kandregula, Amey R Savardekar, Pankaj Sharma, Jerry McLarty, Jennifer Kosty, Krystle Trosclair, Hugo Cuellar, Bharat Guthikonda
OBJECTIVE: A paradigm shift in the management of acute ischemic stroke (AIS) due to large-vessel occlusion (LVO) occurred after 2015 when 7 randomized controlled trials demonstrated better outcomes using second-generation thrombectomy devices combined with best medical management than did stand-alone intravenous thrombolysis (IVT) with tissue plasminogen activator (tPA). All recently published landmark trials were designed to study the outcome of mechanical thrombectomy (MT); therefore, the majority of the patients enrolled in these trials received intravenous tPA...
July 2021: Neurosurgical Focus