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stroke, tPA, thrombolysis, atrial fibrillation, intracerebral hemorrhage

Mahesh Kate, Artur Szkotak, Adam Witt, Ashfaq Shuaib, Kenneth Butcher
BACKGROUND: Acute ischemic stroke thrombolysis in patients taking dabigatran is controversial because of a presumed increased risk of symptomatic hemorrhagic transformation. Using data from our local hematopathology laboratory, we developed a thrombolysis protocol for acute ischemic stroke patients taking dabigatran. METHODS: A local thrombin time (TT)-dabigatran concentration relationship was calculated using dabigatran calibrators. The effect of dabigatran on activated partial thromboplastin time (aPTT) and prothrombin time (PT) (international normalized ratio [INR]) was also measured...
July 2014: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Gustavo Saposnik, David Gladstone, Roula Raptis, Limei Zhou, Robert G Hart
BACKGROUND AND PURPOSE: Atrial fibrillation (AF) increases the risk of stroke and is associated with poor stroke outcomes. Limited tools are available to evaluate clinical outcomes and response to thrombolysis in stroke patients with AF. METHODS: We applied the iScore (, a validated risk score, to consecutive patients with an acute ischemic stroke admitted to stroke centers in the Registry of the Canadian Stroke Network. The main outcome considered was a favorable outcome (defined as a modified Rankin scale 0-2) at discharge after thrombolysis...
January 2013: Stroke; a Journal of Cerebral Circulation
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