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capsaicin, H pylori

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https://www.readbyqxmd.com/read/27094759/a-prospective-study-on-symptom-generation-according-to-spicy-food-intake-and-trpv1-genotypes-in-functional-dyspepsia-patients
#1
S-Y Lee, T Masaoka, H S Han, J Matsuzaki, M J Hong, S Fukuhara, H S Choi, H Suzuki
BACKGROUND: Capsaicin is an ingredient of red peppers that binds to transient receptor potential vanilloid subtype 1 (TRPV1), and Koreans eat more capsaicin-rich food than do Japanese. This study aimed to compare symptom generation according to TRPV1 genotypes and the intake of spicy foods. METHODS: Consecutive functional dyspepsia (FD) patients who were evaluated at Konkuk University Medical Centre (Korea) and Keio University Hospital (Japan) were included. Questionnaires on spicy food intake, patient assessment of gastrointestinal symptoms (PAGI-SYM), patient assessment of quality of life, and hospital anxiety and depression scale were provided...
September 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/26140520/anti-inflammatory-effects-of-capsaicin-and-piperine-on-helicobacter-pylori-induced-chronic-gastritis-in-mongolian-gerbils
#2
Takeshi Toyoda, Liang Shi, Shinji Takasu, Young-Man Cho, Yuka Kiriyama, Akiyoshi Nishikawa, Kumiko Ogawa, Masae Tatematsu, Tetsuya Tsukamoto
BACKGROUND: Spices have been used for thousands of years, and recent studies suggest that certain spices confer beneficial effects on gastric disorders. The purpose of this study was to evaluate possible chemopreventive effects of spice-derived compounds on Helicobacter pylori (H. pylori)-induced gastritis. METHODS: We examined the inhibitory effects of curcumin, capsaicin, and piperine on H. pylori in vitro by determining the colony-forming units and real-time RT-PCR in H...
April 2016: Helicobacter
https://www.readbyqxmd.com/read/24756832/the-impact-of-capsaicin-intake-on-risk-of-developing-gastric-cancers-a-meta-analysis
#3
Noel Pabalan, Hamdi Jarjanazi, Hilmi Ozcelik
BACKGROUND: Reported associations of capsaicin with gastric cancer development have been conflicting. Here, we examine 10 published articles that explore these associations using 2,452 cases and 3,996 controls. METHODS: We used multiple search strategies in MEDLINE through PubMed to seek for suitable articles that had case-control design with gastric cancer as outcome. RESULTS: The outcomes of our study shows protection (odds ratio [OR] 0...
September 2014: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/23392237/h-pylori-acutely-inhibits-gastric-secretion-by-activating-cgrp-sensory-neurons-coupled-to-stimulation-of-somatostatin-and-inhibition-of-histamine-secretion
#4
Muhammad Zaki, Philip E Coudron, Robert W McCuen, Leslie Harrington, Shijian Chu, Mitchell L Schubert
Acute Helicobacter pylori infection produces hypochlorhydria. The decrease in acid facilitates survival of the bacterium and its colonization of the stomach. The present study was designed to identify the pathways in oxyntic mucosa by which acute H. pylori infection inhibits acid secretion. In rat fundic sheets in an Ussing chamber, perfusion of the luminal surface with H. pylori in spent broth (10(3)-10(8) cfu/ml) or spent broth alone (1:10(5) to 1:10(0) final dilution) caused a concentration-dependent increase in somatostatin (SST; maximal: 200 ± 20 and 194 ± 9% above basal; P < 0...
April 15, 2013: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/22759327/comparison-of-lafutidine-and-rabeprazole-in-7-day-second-line-amoxicillin-and-metronidazole-containing-triple-therapy-for-helicobacter-pylori-a-pilot-study
#5
RANDOMIZED CONTROLLED TRIAL
Takahiko Kudo, Haruka Fujinami, Takayuki Ando, Jun Nishikawa, Kohei Ogawa, Ayumu Hosokawa, Tadahiro Orihara, Jun Murakami, Terumi Takahara, Toshiro Sugiyama
BACKGROUND: Lafutidine is an H2-receptor antagonist with gastroprotective action through capsaicin-sensitive afferent neurons and relatively inexpensive compare to proton-pump inhibitors (PPIs). A 7-day course of PPIs-amoxicillin-metronidazole is recommended as standard second-line Helicobacter pylori therapy and is covered by national health insurance in Japan. The aim of this study was to determine the efficacy and safety of second-line eradication using the H2-receptor antagonist lafutidine as a substitute for a PPI...
August 2012: Helicobacter
https://www.readbyqxmd.com/read/22484287/differential-changes-in-substance-p-vip-as-well-as-neprilysin-levels-in-patients-with-gastritis-or-ulcer
#6
Nuray Erin, Sema Türker, Ozlem Elpek, Bülent Yıldırım
The protective effect of capsaicin-sensitive sensory nerve (CSSN) activation was recently demonstrated in human gastric mucosa. We here examined changes in neuropeptides, specifically Substance P (SP), calcitonin-gene related peptide (CGRP) and vasoactive intestinal peptide (VIP) in patients with chronic gastritis or ulcer. Furthermore changes in neprilysin levels, which hydrolyse these neuropeptides, were determined. Gastric biopsies were obtained from both lesion- and normal-appearing mucosa of 57 patients...
June 2012: Peptides
https://www.readbyqxmd.com/read/22414649/capsaicin-consumption-helicobacter-pylori-caga-status-and-il1b-31c-t-genotypes-a-host-and-environment-interaction-in-gastric-cancer
#7
Lizbeth López-Carrillo, M Constanza Camargo, Barbara G Schneider, Liviu A Sicinschi, Raúl U Hernández-Ramírez, Pelayo Correa, Mariano E Cebrian
Gastric cancer (GC) has been associated with a complex combination of genetic and environmental factors. In contrast to most countries, available information on GC mortality trends showed a gradual increase in Mexico. Our aim was to explore potential interactions among dietary (chili pepper consumption), infectious (Helicobacter pylori) and genetic factors (IL1B-31 genotypes) on GC risk. The study was performed in three areas of Mexico, with different GC mortality rates. We included 158 GC patients and 317 clinical controls...
June 2012: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/22046579/capsaicin-sensitive-afferentation-represents-an-indifferent-defensive-pathway-from-eradication-in-patients-with-h-pylori-gastritis
#8
Lilla Lakner, András Dömötör, Csaba Tóth, Imre L Szabó, Agnes Meczker, Rebeka Hajós, László Kereskai, György Szekeres, Zoltán Döbrönte, Gyula Mózsik
AIM: To study the role of capsaicin-sensitive afferent nerves in Helicobacter pylori (H. pylori) positive chronic gastritis before and after eradication. METHODS: Gastric biopsy samples were obtained from corpus and antrum mucosa of 20 healthy human subjects and 18 patients with H. pylori positive chronic gastritis (n = 18) before and after eradication. Traditional gastric mucosal histology (and Warthin-Starry silver impregnation) and special histochemical examinations were carried out...
October 6, 2011: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/20880171/lafutidine-prevents-low-dose-aspirin-and-loxoprofen-induced-gastric-injury-a-randomized-double-blinded-placebo-controlled-study
#9
RANDOMIZED CONTROLLED TRIAL
Mototsugu Kato, Go Kamada, Keiko Yamamoto, Urara Nishida, Aki Imai, Takeshi Yoshida, Shouko Ono, Manabu Nakagawa, Soichi Nakagawa, Yuichi Shimizu, Masahiro Asaka
BACKGROUND AND AIM: The concomitant use of non-steroidal anti-inflammatory drugs is a risk factor for low-dose aspirin (LDA)-associated upper gastrointestinal toxicity. Lafutidine is an H2-receptor antagonist with gastroprotective activity, produced by acting on capsaicin-sensitive afferent neurons. To evaluate the preventive effect of lafutidine on gastric damage caused by LDA alone and by the combination of both LDA and loxoprofen, we conducted a clinical study using healthy volunteers...
October 2010: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/19853593/protective-effect-of-anacardic-acids-from-cashew-anacardium-occidentale-on-ethanol-induced-gastric-damage-in-mice
#10
Talita C Morais, Natália B Pinto, Karine Maria M B Carvalho, Jeison B Rios, Nagila Maria P S Ricardo, Maria Teresa S Trevisan, Vietla S Rao, Flávia A Santos
Cashew nut-shell liquid and the contained anacardic acids (AAs) have been shown to possess antioxidant, lipoxygenase inhibitory, anti-Helicobacter pylori and antitumor properties. Despite these known effects, hitherto there were no published reports on their likely gastroprotective effects. The present study was designed to verify whether AAs afford gastroprotection against the ethanol-induced gastric damage and to examine the underlying mechanism(s). Gastric damage was induced by intragastric administration of 0...
January 5, 2010: Chemico-biological Interactions
https://www.readbyqxmd.com/read/19208342/delineation-of-the-chemomechanosensory-regulation-of-gastrin-secretion-using-pure-rodent-g-cells
#11
Mark Kidd, Øyvind Hauso, Ignat Drozdov, Bjorn I Gustafsson, Irvin M Modlin
BACKGROUND & AIMS: Gastrin is a key regulator of gastric acid secretion. We aimed to isolate pure G cells to identify the mechanistic basis of luminal- and strain-mediated regulation. METHODS: Using gradient centrifugation and fluorescence-activated cell sorting, rat G cells were prepared and luminal, neural, hormonal, and mechanical activation of secretion and signaling pathways studied. RESULTS: Pure G-cell preparations (>97%) were isolated...
July 2009: Gastroenterology
https://www.readbyqxmd.com/read/17760719/anti-inflammatory-effect-of-capsaicin-in-helicobacter-pylori-infected-gastric-epithelial-cells
#12
In Ohk Lee, Kwang Hyoung Lee, Jae Hee Pyo, Jie Hyun Kim, Yeun Jung Choi, Yong Chan Lee
BACKGROUND AND AIM: Capsaicin, the main pungent ingredient of hot red and chilli pepper, has been considered as not only a cytoprotective but also a detrimental agent to the gastric mucosa. However, the effect and mechanism of capsaicin that modulate the induction of pro-inflammatory cytokine in Helicobacter pylori-infected epithelial cells have not been investigated previously. Herein, we demonstrated that capsaicin inhibited the release of pro-inflammatory cytokine, interleukin-8 (IL-8) by H...
October 2007: Helicobacter
https://www.readbyqxmd.com/read/17195120/participation-of-capsaicin-sensitive-afferent-nerves-in-the-gastric-mucosa-of-patients-with-helicobacter-pylori-positive-or-negative-chronic-gastritis
#13
COMPARATIVE STUDY
A Dömötör, L Kereskay, Gy Szekeres, B Hunyady, J Szolcsányi, Gy Mózsik
Capsaicin-sensitive afferent nerves (CSANs) are involved in the protection of gastric mucosa. To clarify the role of CSANs in human Helicobacter pylori-negative or -positive chronic gastritis, after bacterium detection by rapid urease test, (14)C urea breath test, and specific histological staining, the immunodistribution of capsaicin receptor, calcitonin gene-related peptide (CGRP), and substance P (SP) was studied in 21 H. pylori-positive and 30 H. pylori-negative patients with chronic gastritis and 20 patients with functional dyspepsia (as histologically healthy controls)...
February 2007: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/16918426/role-of-sensory-neurons-in-restitution-and-healing-of-gastric-ulcers
#14
REVIEW
S Evangelista
It has been shown that capsaicin-sensitive afferent fibers play a crucial role in acute gastroprotection. Release of neurotransmitters such as calcitonin gene-related peptide (CGRP) and the consequent increase in mucosal blood flow have been identified as key factors in the protective effect of the stimulation of these fibers by capsaicin. Conversely the involvement of sensory nerves in the process of tissue repair after acute and chronic gastric mucosal damage has remained largely unexplored. Some studies, however, while demonstrating that the process of rapid repair (restitution) of the gastric mucosa damaged by ethanol is unaffected by capsaicin pretreatment, have shown that the recovery of gastric integrity after mucosal damage induced by sodium taurocholate or monochloramine, a known cytotoxic agent present in H...
2006: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/12800206/capsaicin-consumption-helicobacter-pylori-positivity-and-gastric-cancer-in-mexico
#15
COMPARATIVE STUDY
Lizbeth López-Carrillo, Malaquías López-Cervantes, Guillermo Robles-Díaz, Armando Ramírez-Espitia, Alejandro Mohar-Betancourt, Abelardo Meneses-García, Yolanda López-Vidal, Aaron Blair
Gastric cancer (GC) incidence has not declined in Mexico. We assessed whether the intake of capsaicin (CAP), the pungent compound of chili peppers, increases the risk of GC independently of H. pylori positivity (Hp). From 1994 to 1996, a hospital-based case-control study was performed in 3 areas of Mexico; 234 cases of GC and 468 matched controls were enrolled and their diet and other characteristics were inquired. Chili pepper intake was queried by interview and CAP content of chilies was determined in a separate analysis by gas chromatography to estimate CAP intake; IGg Hp serum antibodies were determined by ELISA...
August 20, 2003: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/10519955/helicobacter-pylori-novel-therapies
#16
REVIEW
E Drouin
The ideal therapy for Helicobacter pylori would cure the infection without resulting in the development of antibiotic resistance. Current therapies have variable cure rates; the reasons for treatment failure include bacterial resistance and poor compliance. Some antibiotics, such as furazolidone, may be affordable agents to treat this infection worldwide. New proton pump inhibitors, such as rabeprazole, can potentiate antibiotics. Nutriceuticals and probiotics demonstrate interesting in vitro activity against H pylori...
September 1999: Canadian Journal of Gastroenterology, Journal Canadien de Gastroenterologie
https://www.readbyqxmd.com/read/10235193/garlic-or-jalape%C3%A3-o-peppers-for-treatment-of-helicobacter-pylori-infection
#17
D Y Graham, S Y Anderson, T Lang
OBJECTIVE: There have been a number of reports that natural foods such as garlic, honey, and capsaicin can inhibit Helicobacter pylori in vitro and each report has suggested the natural ingredient be used for treatment of the infection. We investigated whether garlic or capsaicin-containing peppers would actually inhibit H. pylori in vivo. METHODS: We performed a prospective crossover study in healthy H. pylori-infected adults. We used the urea breath test to assess the status of the H...
May 1999: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/9098824/physiological-immunohistochemical-and-molecular-aspects-of-gastric-adaptation-to-stress-aspirin-and-to-h-pylori-derived-gastrotoxins
#18
REVIEW
P C Konturek
Gastric mucosa is continuously exposed to various aggressive factors such as stress, ulcerogenic drugs including aspirin-like agents, gastrotoxic bacteria, particularly Helicobacter pylori (Hp) and many other exogenous and endogenous irritants. The maintenance of mucosal barrier depends upon the activation of pre-epithelial (mucus-alkaline secretion), epithelial (surface active phospholipids, mucosal cell restitution and proliferation) and post-epithelial (mucosal microcirculation) lines of mucosal defence...
March 1997: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/9011042/capsaicin-as-an-inhibitor-of-the-growth-of-the-gastric-pathogen-helicobacter-pylori
#19
N L Jones, S Shabib, P M Sherman
Capsaicin, the active ingredient in chili, has been implicated as both a cytoprotective and a detrimental agent to the gastric mucosa. The effect of capsaicin on Helicobacter pylori has not been investigated previously. Therefore, we performed in vitro time- and concentration-dependent studies to examine the growth of H. pylori in the presence of capsaicin. Capsaicin specifically inhibited growth of H. pylori dose-dependently at concentrations greater than 10 micrograms ml-1 (P < 0.05) but did not inhibit the growth of a human fecal commensal Escherichia coli strain...
January 15, 1997: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/8888429/mucosal-irritation-adaptive-cytoprotection-and-adaptation-to-topical-ammonia-in-the-rat-stomach
#20
T Brzozowski, P C Konturek, S J Konturek, H Ernst, K Sliwowski, E G Hahn
BACKGROUND: The urease-ammonia (NH4OH) system has been proposed to play a major role in the pathogenesis of the Helicobacter pylori-associated gastritis, but the mechanism of the mucosal damage has not been fully explained. This study was designed to examine possible adaptive cytoprotection and the adaptation of rat gastric mucosa to the irritant action of NH4OH and urease. METHODS AND RESULTS: Single application of NH4OH alone in various concentrations (15-500 mM) caused concentration-dependent mucosal damage starting with 30 mM and reaching a maximum at 250 mM NH4OH, similar to that obtained with 100% ethanol; it was accompanied by a decrease in gastric blood flow (GBF) to approximately 30% of the normal value...
September 1996: Scandinavian Journal of Gastroenterology
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