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Alcoholism as a choice

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https://www.readbyqxmd.com/read/28095875/assessment-of-synthetic-floral-based-attractants-and-sugar-baits-to-capture-male-and-female-aedes-aegypti-diptera-culicidae
#1
Kara Fikrig, Brian J Johnson, Durland Fish, Scott A Ritchie
BACKGROUND: The viruses transmitted by Aedes aegypti, including dengue and Zika viruses, are rapidly expanding in geographic range and as a threat to public health. In response, control programs are increasingly turning to the use of sterile insect techniques resulting in a need to trap male Ae. aegypti to monitor the efficacy of the intervention. However, there is a lack of effective and cheap methods for trapping males. Thus, we attempted to exploit the physiological need to obtain energy from sugar feeding in order to passively capture male and female Ae...
January 17, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28092494/zebrafish-are-able-to-detect-ethanol-in-their-environment
#2
Steven Tran, Hayden Chow, Benjamin Tsang, Amanda Facciol, Prabhlene Gandhi, Priyanka Desai, Robert Gerlai
Zebrafish have become a popular animal model for studying the development of alcohol addiction. Several behavioral paradigms for studying alcohol addiction have been developed for zebrafish, including conditioned place preference, alcohol-induced tolerance, and withdrawal. However, alcohol choice preference tasks have not been established in zebrafish as of yet. The ability of zebrafish to detect alcohol in their environment is required in alcohol choice or preference tasks. To our knowledge, it is currently unknown whether zebrafish are able to detect alcohol in their environment immediately following bath immersion...
January 16, 2017: Zebrafish
https://www.readbyqxmd.com/read/28063241/health-risk-factors-associated-with-lifetime-abstinence-from-alcohol-in-the-1979-national-longitudinal-survey-of-youth-cohort
#3
William C Kerr, Camillia K Lui, Edwina Williams, Yu Ye, Thomas K Greenfield, E Anne Lown
BACKGROUND: The choice and definition of a comparison group in alcohol-related health studies remains a prominent issue in alcohol epidemiology due to potential biases in the risk estimates. The most commonly used comparison group has been current abstainers; however, this includes former drinkers who may have quit drinking due to health problems. Lifetime abstention could be the best option, but measurement issues, selection biases due to health and other risk factors, and small numbers in populations are important concerns...
January 7, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28063221/novel-circulating-biomarkers-for-non-alcoholic-fatty-liver-disease-a-systematic-review
#4
REVIEW
Amirhossein Sahebkar, Elena Sancho, David Abelló, Jordi Camps, Jorge Joven
Currently, a liver biopsy remains the only reliable way to precisely diagnose non-alcoholic fatty liver disease (NAFLD) and establish the severity of liver injury, presence of fibrosis and architecture remodeling. However, the cost and the intrinsic invasive procedure of a liver biopsy rules it out as a gold standard diagnostic test, and the imaging test are not the best choice due to the price, and currently is being refined. The lack of a biomarker of NAFLD pushes to develop this new line of research. The aim of the present systematic review is to clarify and update all the NAFLD biomarkers described in the literature until recently...
January 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28061017/feasibility-and-safety-of-extended-release-naltrexone-treatment-of-opioid-and-alcohol-use-disorder-in-hiv-clinics-a-pilot-feasibility-randomized-trial
#5
P Todd Korthuis, Paula J Lum, Pamela Vergara-Rodriguez, Keith Ahamad, Evan Wood, Lynn E Kunkel, Neal L Oden, Robert Lindblad, James L Sorensen, Virgilio Arenas, Doan Ha, Raul N Mandler, Dennis Mccarty
BACKGROUND AND AIMS: HIV-infected persons with substance use disorders are least likely to benefit from advances in HIV treatment. Integration of extended-release naltrexone (XR-NTX) into HIV clinics may increase engagement in the HIV care continuum by decreasing substance use. We aimed to compare 1) XR-NTX treatment initiation, 2) retention, and 3) safety of XR-NTX versus treatment as usual (TAU) for treating opioid use disorder (OUD) and/or alcohol use disorder (AUD) in HIV clinics...
January 6, 2017: Addiction
https://www.readbyqxmd.com/read/28049515/validation-of-the-audit-c-in-adults-seeking-help-with-their-drinking-online
#6
Zarnie Khadjesari, Ian R White, Jim McCambridge, Louise Marston, Paul Wallace, Christine Godfrey, Elizabeth Murray
BACKGROUND: The abbreviated Alcohol Use Disorder Identification Test for Consumption (AUDIT-C) is rapidly becoming the alcohol screening tool of choice for busy practitioners in clinical settings and by researchers keen to limit assessment burden and reactivity. Cut-off scores for detecting drinking above recommended limits vary by population, setting, country and potentially format. This validation study aimed to determine AUDIT-C thresholds that indicated risky drinking among a population of people seeking help over the Internet...
January 4, 2017: Addiction Science & Clinical Practice
https://www.readbyqxmd.com/read/28042657/the-influence-of-mixers-containing-artificial-sweetener-or-different-doses-of-carbohydrate-on-breath-alcohol-responses-in-females
#7
Cassie Smith, Peter John Herzig, Andrew Davey, Ben Desbrow, Christopher Irwin
BACKGROUND: Breath alcohol responses may be affected by the presence of carbohydrate (CHO) in a beverage. This study investigated the impact of consuming alcohol with mixers containing various doses of CHO or an artificial sweetener on breath alcohol concentration (BrAC), ratings of intoxication and impairment, and cognitive performance in females. METHODS: Twenty-six females (age 25.1 ± 0.7 years, mean ± standard deviation) completed a crossover study involving 4 trials...
January 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28042141/prolonged-unexplained-hypoxemia-as-initial-presentation-of-cirrhosis-a-case-report
#8
Anand Puttappa, Kumaraswamy Sheshadri, Aurelie Fabre, Georgina Imberger, John Boylan, Silke Ryan, Masood Iqbal, Niamh Conlon
BACKGROUND Hepatopulmonary syndrome (HPS) is a pulmonary complication of advanced liver disease with dyspnea as the predominant presenting symptom. The diagnosis of HPS can often be missed due to its nonspecific presentation and the presence of other comorbidities. CASE REPORT We present an interesting case of an obese 43-year-old man who presented with progressive, unexplained hypoxemia and shortness of breath in the absence of any symptoms or signs of chronic liver disease. After extensive cardiopulmonary investigations, he was diagnosed with severe HPS as a result of non-alcoholic steatohepatitis (NASH) leading to cirrhosis...
January 2, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28038363/relationship-of-nicotine-deprivation-and-indices-of-alcohol-use-behavior-to-implicit-alcohol-and-cigarette-approach-cognitions-in-smokers
#9
Amy Cohn, Sarah Ehlke, Caroline O Cobb
Alcohol and smoking frequently co-occur and alcohol is a primary trigger for smoking behavior and relapse back to smoking. This study examined whether several indices of alcohol use behavior and consequences of use would be associated with changes in implicit alcohol-approach versus implicit cigarette-approach cognitions under cigarette deprived and non-deprived cognitions in 109 smokers who drank at risky or non-risky levels. An Implicit Association Task (IAT) measured how quickly respondents paired alcohol and cigarette pictures with approach and avoid words...
December 9, 2016: Addictive Behaviors
https://www.readbyqxmd.com/read/28018479/acupuncture-as-an-intervention-to-reduce-alcohol-dependency-a-systematic-review-and-meta-analysis
#10
REVIEW
Charlotte Southern, Charlie Lloyd, Jianping Liu, Congcong Wang, Tingting Zhang, Martin Bland, Hugh MacPherson
BACKGROUND: Acupuncture has been widely used as a treatment for alcohol dependence. An updated and rigorously conducted systematic review is needed to establish the extent and quality of the evidence on the effectiveness of acupuncture as an intervention for reducing alcohol dependence. This review aimed to ascertain the effectiveness of acupuncture for reducing alcohol dependence as assessed by changes in either craving or withdrawal symptoms. METHODS: In this systematic review, a search strategy was designed to identify randomised controlled trials (RCTs) published in either the English or Chinese literature, with a priori eligibility criteria...
2016: Chinese Medicine
https://www.readbyqxmd.com/read/28017180/comparison-of-12-step-groups-to-mutual-help-alternatives-for-aud-in-a-large-national-study-differences-in-membership-characteristics-and-group-participation-cohesion-and-satisfaction
#11
Sarah E Zemore, Lee Ann Kaskutas, Amy Mericle, Jordana Hemberg
BACKGROUND: Many studies suggest that participation in 12-step groups contributes to better recovery outcomes, but people often object to such groups and most do not sustain regular involvement. Yet, research on alternatives to 12-step groups is very sparse. The present study aimed to extend the knowledge base on mutual help group alternatives for those with an alcohol use disorder (AUD), sampling from large, active, abstinence-focused groups including Women for Sobriety (WFS), LifeRing, and SMART Recovery (SMART)...
February 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28001464/differences-by-gender-in-predictors-of-motivation-among-substance-abuse-treatment-participants
#12
Liana R Taylor, Michael Caudy, Brandy L Blasko, Faye S Taxman
BACKGROUND: Substance-involved females tend to have different clinical profiles than men (Adams, Leukefeld, & Peden, 2008 ); yet they do not appear to have worse treatment outcomes (Green, 2006 ; Hser, Huang, Teruya, & Anglin, 2003 ). As motivation for treatment is considered essential in the substance abuse treatment context (Cahill, Adinoff, Hosig, Muller, & Pulliam, 2003 ; Longshore & Teruya, 2006 ), it is possible that higher motivation among females could potentially counteract the negative effect of more risk factors...
December 21, 2016: Substance Use & Misuse
https://www.readbyqxmd.com/read/28000083/impulsivity-in-rodents-with-a-genetic-predisposition-for-excessive-alcohol-consumption-is-associated-with-a-lack-of-a-prospective-strategy
#13
David N Linsenbardt, Michael P Smoker, Sarine S Janetsian-Fritz, Christopher C Lapish
Increasing evidence supports the hypothesis that impulsive decision-making is a heritable risk factor for an alcohol use disorder (AUD). Clearly identifying a link between impulsivity and AUD risk, however, is complicated by the fact that both AUDs and impulsivity are heterogeneous constructs. Understanding the link between the two requires identifying the underlying cognitive factors that lead to impulsive choices. Rodent models have established that a family history of excessive drinking can lead to the expression of a transgenerational impulsive phenotype, suggesting heritable alterations in the decision-making process...
December 20, 2016: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/28000031/paradoxical-antidepressant-effects-of-alcohol-are-related-to-acid-sphingomyelinase-and-its-control-of-sphingolipid-homeostasis
#14
Christian P Müller, Liubov S Kalinichenko, Jens Tiesel, Matthias Witt, Thomas Stöckl, Eva Sprenger, Jens Fuchser, Janine Beckmann, Marc Praetner, Sabine E Huber, Davide Amato, Christiane Mühle, Christian Büttner, Arif B Ekici, Irena Smaga, Lucyna Pomierny-Chamiolo, Bartosz Pomierny, Malgorzata Filip, Volker Eulenburg, Erich Gulbins, Anbarasu Lourdusamy, Martin Reichel, Johannes Kornhuber
Alcohol is a widely consumed drug that can lead to addiction and severe brain damage. However, alcohol is also used as self-medication for psychiatric problems, such as depression, frequently resulting in depression-alcoholism comorbidity. Here, we identify the first molecular mechanism for alcohol use with the goal to self-medicate and ameliorate the behavioral symptoms of a genetically induced innate depression. An induced over-expression of acid sphingomyelinase (ASM), as was observed in depressed patients, enhanced the consumption of alcohol in a mouse model of depression...
December 20, 2016: Acta Neuropathologica
https://www.readbyqxmd.com/read/27987279/falsely-elevated-troponin-rare-occurrence-or-future-problem
#15
James Nguyen, Rosy Thachil, Neil Vyas, Thomas Marino
INTRODUCTION: Troponins are known to be released in response to cardiac damage and therefore are the biomarkers of choice for the early diagnosis of acute myocardial infarction (AMI), improving outcome in patients presenting with chest pain. However, false results can occur due to interference from other substances in the blood. CASE: A 52-year-old male with a past medical history of alcohol abuse, hypertension, and coronary artery bypass graft at age 34 with normal stress test 2 years before presented to the emergency department (ED) complaining of 1 day of non-exertional chest pain with radiation to the neck and left arm...
2016: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/27975130/does-alcohol-consumption-modify-the-risk-of-endometrial-cancer-a-dose-response-meta-analysis-of-prospective-studies
#16
Quan Zhou, Peng Guo, Hui Li, Xiao-Dan Chen
BACKGROUND: Epidemiological studies have provided controversial evidence of an association between alcohol intake and endometrial cancer (EC) risk. The World Cancer Research Fund/American Institute for Cancer Research classifies alcohol as having a "limited-no conclusion" grade of evidence in the Endometrial Cancer 2013 Report (the latest version). OBJECTIVE: The purpose of this meta-analysis is to systematically analyze the effect of alcohol intake on EC risk. METHODS: We conducted a dose-response meta-analysis of prospective cohort studies identified from the PubMed, Embase, Cochrane Library and China Biological Medicine databases...
December 14, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27957661/-it-s-been-an-experience-a-life-learning-experience-a-qualitative-study-of-hospitalized-patients-with-substance-use-disorders
#17
Christine M Velez, Christina Nicolaidis, P Todd Korthuis, Honora Englander
BACKGROUND: Individuals with substance use disorders (SUD) have high rates of chronic illness and readmission, yet few are engaged in addiction treatment. Hospitalization may be a reachable moment for initiating and coordinating addiction care, but little is known about motivation for change in the inpatient setting. OBJECTIVE: To explore the experiences of hospitalized adults with SUD and to better understand patient and system level factors impacting readiness for change...
December 12, 2016: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/27938644/creating-exclusive-breastfeeding-knowledge-translation-tools-with-first-nations-mothers-in-northwest-territories-canada
#18
Pertice Moffitt, Raissa Dickinson
BACKGROUND: Breastfeeding is an ideal method of infant feeding affecting lifelong health, and yet the uptake of breastfeeding in some Indigenous communities in Canada's north is low. OBJECTIVE: The aims of this project were to determine the rate and determinants of exclusive breastfeeding in a remote community in the Northwest Territories and to create knowledge translation tools to enhance breastfeeding locally. METHODS: The study methodology followed three steps...
2016: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/27936682/catalytic-kinetic-resolution-of-saturated-n-heterocycles-by-enantioselective-amidation-with-chiral-hydroxamic-acids
#19
Imants Kreituss, Jeffrey W Bode
The preparation of enantioenriched chiral compounds by kinetic resolution dates back to the laboratories of Louis Pasteur in the middle of the 19th century. Unlike asymmetric synthesis, this process can always deliver enantiopure material (ee > 99%) if the reactions are allowed to proceed to sufficient conversion and the selectivity of the process is not unity (s > 1). One of the most appealing and practical variants is acylative kinetic resolution, which affords easily separable reaction products, and several highly efficient enzymatic and small molecule catalysts are available...
December 20, 2016: Accounts of Chemical Research
https://www.readbyqxmd.com/read/27936371/testing-cross-sectional-and-prospective-mediators-of-internalized-heterosexism-on-heavy-drinking-alcohol-problems-and-psychological-distress-among-heavy-drinking-men-who-have-sex-with-men
#20
Alexis Kuerbis, Ethan H Mereish, Marie Hayes, Christine M Davis, Sijing Shao, Jon Morgenstern
OBJECTIVE: Minority stress theory is one of the primary theories used to understand substance use among lesbian, gay, and bisexual populations. This study tested whether drinking to cope with stress (DTC), loneliness, and gay community participation (GCP) mediated the relationship between one type of minority stress (i.e., internalized heterosexism) and behavioral health outcomes. METHOD: Using secondary data analysis and the PROCESS procedure, relationships between internalized heterosexism, the mediators (DTC, loneliness, and GCP), and outcomes (heavy drinking, alcohol problems, and psychological distress) were explored, both cross-sectionally and in a lagged manner, among both treatment-seeking and non-treatment-seeking problem drinking men who have sex with men...
January 2017: Journal of Studies on Alcohol and Drugs
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