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Alcoholism as a choice

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https://www.readbyqxmd.com/read/29682541/madelung-s-disease-lipectomy-or-liposuction
#1
REVIEW
Chun-Ye Chen, Qing-Qing Fang, Xiao-Feng Wang, Min-Xia Zhang, Wan-Yi Zhao, Bang-Hui Shi, Li-Hong Wu, Li-Yun Zhang, Wei-Qiang Tan
Background: Madelung's disease is a rare lipid metabolic disorder characterized by diffuse, uncapsulated lipomas in the neck, shoulder, and other areas. It mainly affects middle-aged men and is related to alcohol abuse, and the cause is not clear. Surgical treatments include lipectomy and liposuction. Methods: This systematic review analyzed the treatment of Madelung's disease described in 52 articles including complete patient details, published between 2000 and 2015, and retrieved from the Web of Science, PubMed, Medline, and Embase...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29673059/the-tlr4-ire1%C3%AE-pathway-activation-contributes-to-palmitate-elicited-lipotoxicity-in-hepatocytes
#2
Chen Shen, Wang Ma, Lei Ding, Songtao Li, Xiaobing Dou, Zhenyuan Song
Lipotoxicity induced by saturated fatty acids (SFAs) plays a pathological role in the development of non-alcoholic fatty liver disease (NAFLD); however, the exact mechanism(s) remain to be clearly elucidated. Toll-like receptor (TLR) 4 plays a fundamental role in activating the innate immune system. Intriguingly, hepatocytes express TLR4 and machinery for TLR4 signalling pathway. That liver-specific TLR4 knockout mice are protective against diet-induced NAFLD suggests that hepatocyte TLR4 signalling pathway plays an important role in NAFLD pathogenesis...
April 19, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29652882/association-between-supplementary-private-health-insurance-and-visits-to-physician-offices-versus-hospital-outpatient-departments-among-adults-with-diabetes-in-the-universal-public-insurance-system
#3
Chang Hoon You, Ji Heon Choi, Sungwook Kang, Eun-Hwan Oh, Young Dae Kwon
BACKGROUND: Diabetes mellitus is a chronic disease with a high prevalence across the world as well as in South Korea. Most cases of diabetes can be adequately managed at physician offices, but many diabetes patients receive outpatient care at hospitals. This study examines the relationship between supplementary private health insurance (SPHI) ownership and the use of hospitals among diabetes outpatients within the universal public health insurance scheme. METHODS: Data from the 2011 Korea Health Panel, a nationally representative sample of Korean individuals, was used...
2018: PloS One
https://www.readbyqxmd.com/read/29650620/relationship-between-income-and-mortality-in-a-canadian-family-practice-cohort
#4
Murray Finkelstein
OBJECTIVE: To examine the relationship between household income and mortality in a primary care cohort while using personal information obtained from clinical records and administrative data linkages to adjust for confounders. DESIGN: Survey and analysis of data from several administrative databases. SETTING: Toronto, Ont. PARTICIPANTS: Patients of an urban academic family practice who were aged between 45 and 74 and who had made at least 3 visits to the clinic between 1996 and 1997...
April 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29649518/design-and-optimization-of-gastro-floating-sustained-release-tablet-of-pregabalin-in-vitro-and-in-vivo-evaluation
#5
Chao Qin, Mengmeng Wu, Siyuan Xu, Xiaowei Wang, Wenxing Shi, Yangyu Dong, Lei Yang, Wei He, Xiaopeng Han, Lifang Yin
Pregabalin is a promising drug for the treatment of neuropathic pain, a chronic disease affecting a large population needing long-term treatment. However, due to its short half-life, the commercial tablet has to be administered 2 to 3 times per day, with inconvenience for patient and fluctuations of plasma concentration. In this study, a gastro-floating drug delivery system of pregabalin was developed to prolong the gastric retention of drugs absorbed or act in stomach or upper gastrointestinal tract. First of all, it was proved that the drug was mainly absorbed in stomach and upper gastrointestinal tract...
April 9, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29625579/is-treatment-outcome-improved-if-patients-match-themselves-to-treatment-options-study-protocol-for-a-randomized-controlled-trial
#6
Morten Ellegaard Hell, William R Miller, Bent Nielsen, Anette Søgaard Nielsen
BACKGROUND: Research on matching patients to treatment has shown that matching grounded in expert views is little better than allocating patients by chance. Furthermore, there is growing emphasis on involving patients in their own treatment as a key to health behavior change. Research on the benefit of having patients choose their treatment from among options, in contrast to being assigned to a treatment by experts, has been limited. Consequently, we designed a rigorous test of patient self-matching to determine whether it does improve retention, adherence, and outcome in alcoholism treatment...
April 6, 2018: Trials
https://www.readbyqxmd.com/read/29619082/self-sustained-enzymatic-cascade-for-the-production-of-2-5-furandicarboxylic-acid-from-5-methoxymethylfurfural
#7
Juan Carro, Elena Fernández-Fueyo, Carmen Fernández-Alonso, Javier Cañada, René Ullrich, Martin Hofrichter, Miguel Alcalde, Patricia Ferreira, Angel T Martínez
Background: 2,5-Furandicarboxylic acid is a renewable building block for the production of polyfurandicarboxylates, which are biodegradable polyesters expected to substitute their classical counterparts derived from fossil resources. It may be produced from bio-based 5-hydroxymethylfurfural or 5-methoxymethylfurfural, both obtained by the acidic dehydration of biomass-derived fructose. 5-Methoxymethylfurfural, which is produced in the presence of methanol, generates less by-products and exhibits better storage stability than 5-hydroxymethylfurfural being, therefore, the industrial substrate of choice...
2018: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29595339/antifeedant-activity-of-long-chain-alcohols-and-fungal-and-plant-metabolites-against-pea-aphid-acyrthosiphon-pisum-as-potential-biocontrol-strategy
#8
Thaïs Aznar-Fernández, Alessio Cimmino, Marco Masi, Diego Rubiales, Antonio Evidente
Aphids are noxious insect pests of major crops including cereals and legumes. Particularly, pea aphid (Acyrthosiphon pisum) causes significant yield and quality loses in pea. Crop protection is largely based on noxious chemical pesticides which have prompted a renewed interest in the discovery of natural products as alternatives to synthetic insecticides. In this study different classes of natural compounds were tested in dual choice bioassays to evaluate their feeding deterrence and mortality effect on pea aphid...
March 29, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29595305/self-persuasion-in-media-messages-reducing-alcohol-consumption-among-students-with-open-ended-questions
#9
Jeroen G B Loman, Barbara C N Müller, Arnoud Oude Groote Beverborg, Rick B van Baaren, Moniek Buijzen
Self-persuasion (self-generation of arguments) is often a more effective influence technique than direct persuasion (providing arguments). However, the application of this technique in health media communications has received limited attention. In two experiments, it was examined whether self-persuasion can be successfully applied to antialcohol media communications by framing the message as an open-ended question. In Experiment 1 (N = 131) cognitive reactions to antialcohol posters framed either as open-ended questions or statements were examined...
March 2018: Journal of Experimental Psychology. Applied
https://www.readbyqxmd.com/read/29587686/information-based-cues-at-point-of-choice-to-change-selection-and-consumption-of-food-alcohol-and-tobacco-products-a-systematic-review
#10
Patrice Carter, Giacomo Bignardi, Gareth J Hollands, Theresa M Marteau
BACKGROUND: Reducing harmful consumption of food, alcohol, and tobacco products would prevent many cancers, diabetes and cardiovascular disease. Placing information-based cues in the environments in which we select and consume these products has the potential to contribute to changing these behaviours. METHODS: In this review, information-based cues are defined as those which comprise any combination of words, symbols, numbers or pictures that convey information about a product or its use...
March 27, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29584726/comparative-analysis-of-the-association-between-35-frailty-scores-and-cardiovascular-events-cancer-and-total-mortality-in-an-elderly-general-population-in-england-an-observational-study
#11
Gloria A Aguayo, Michel T Vaillant, Anne-Françoise Donneau, Anna Schritz, Saverio Stranges, Laurent Malisoux, Anna Chioti, Michèle Guillaume, Majon Muller, Daniel R Witte
BACKGROUND: Frail elderly people experience elevated mortality. However, no consensus exists on the definition of frailty, and many frailty scores have been developed. The main aim of this study was to compare the association between 35 frailty scores and incident cardiovascular disease (CVD), incident cancer, and all-cause mortality. Also, we aimed to assess whether frailty scores added predictive value to basic and adjusted models for these outcomes. METHODS AND FINDINGS: Through a structured literature search, we identified 35 frailty scores that could be calculated at wave 2 of the English Longitudinal Study of Ageing (ELSA), an observational cohort study...
March 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29582088/alcohol-related-nurse-care-management-in-primary-care-a-randomized-clinical-trial
#12
Katharine A Bradley, Jennifer F Bobb, Evette J Ludman, Laura J Chavez, Andrew J Saxon, Joseph O Merrill, Emily C Williams, Eric J Hawkins, Ryan M Caldeiro, Carol E Achtmeyer, Diane M Greenberg, Gwen T Lapham, Julie E Richards, Amy K Lee, Daniel R Kivlahan
Importance: Experts recommend that alcohol use disorders (AUDs) be managed in primary care, but effective approaches are unclear. Objective: To test whether 12 months of alcohol care management, compared with usual care, improved drinking outcomes among patients with or at high risk for AUDs. Design, Setting, and Participants: This randomized clinical trial was conducted at 3 Veterans Affairs (VA) primary care clinics. Between October 11, 2011, and September 30, 2014, the study enrolled 304 outpatients who reported heavy drinking (≥4 drinks per day for women and ≥5 drinks per day for men)...
March 26, 2018: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29565820/the-influence-of-place-of-residence-gender-and-age-influence-on-food-group-choices-in-the-spanish-population-findings-from-the-anibes-study
#13
María de Lourdes Samaniego-Vaesken, Teresa Partearroyo, Emma Ruiz, Javier Aranceta-Bartrina, Ángel Gil, Marcela González-Gross, Rosa M Ortega, Lluis Serra-Majem, Gregorio Varela-Moreiras
Socioeconomic factors (SEF) can exert a great impact on food choices. However, limited data are available from the Spanish population. Our aim was to describe the influence of place of residence and habitat size on food group intakes. Data were obtained from the ANIBES study. A 3-day dietary record provided information on food and beverage consumption. Data analysis compared gender, age, Nielsen geographic areas, and habitat population size (urban, semi-urban, and rural). Place of residence did not appear to be a determinant for specific food group consumption during childhood and adolescence, as only higher intakes of non-alcoholic beverages were observed among children aged 9 to 12 years living in the East, when compared to those from the Northwest of Spain ( p < 0...
March 22, 2018: Nutrients
https://www.readbyqxmd.com/read/29564972/social-transfer-of-alcohol-withdrawal-induced-hyperalgesia-in-female-prairie-voles
#14
Andre T Walcott, Monique L Smith, Jennifer M Loftis, Andrey E Ryabinin
The expression of pain serves as a way for animals to communicate potential dangers to nearby conspecifics. Recent research demonstrated that mice undergoing alcohol or morphine withdrawal, or inflammation, could socially communicate their hyperalgesia to nearby mice. However, it is unknown whether such social transfer of hyperalgesia can be observed in other species of rodents. Therefore, the present study investigated if the social transfer of hyperalgesia occurs in the highly social prairie vole (Microtus ochrogaster)...
March 22, 2018: Social Neuroscience
https://www.readbyqxmd.com/read/29557802/patient-and-system-characteristics-associated-with-performance-on-the-hedis-measures-of-alcohol-and-other-drug-treatment-initiation-and-engagement
#15
Bobbi Jo H Yarborough, Felicia W Chi, Carla A Green, Agatha Hinman, Jennifer Mertens, Arne Beck, Michael Horberg, Constance Weisner, Cynthia I Campbell
OBJECTIVES: Understand patient and system characteristics associated with performance on the Healthcare Effectiveness Data and Information Set (HEDIS) Alcohol and Other Drug (AOD) Initiation and Engagement of Treatment (IET) measures. METHODS: This mixed-methods study linked patient and health system data from four Kaiser Permanente regions to HEDIS performance measure data for 44,320 commercially or Medicare-insured adults with HEDIS-eligible AOD diagnoses in 2012...
March 19, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29546282/a-qualitative-exploration-of-the-shift-work-experience-the-perceived-effect-on-eating-habits-lifestyle-behaviours-and-psychosocial-wellbeing
#16
Fiona M Nea, L Kirsty Pourshahidi, John M Kearney, M Barbara E Livingstone, Carolina Bassul, Clare A Corish
Background: Approximately 17% of the European workforce is engaged in shift work. How the experience of shift work impacts on the dietary and lifestyle practices of workers is unclear. Methods: Overall, 15 focus groups were conducted by two researchers, with 109 participants. The initial focus group was carried out with both researchers present, to ensure consistency in facilitation. Both researchers thematically analysed all data collected. Results: Shift work was described as affecting many areas of workers' lives...
March 13, 2018: Journal of Public Health
https://www.readbyqxmd.com/read/29536529/cluster-headache-clinical-phenotypes-tobacco-nonexposed-never-smoker-and-no-parental-secondary-smoke-exposure-as-a-child-versus-tobacco-exposed-results-from-the-united-states-cluster-headache-survey
#17
Todd D Rozen
OBJECTIVE: To present results from the United States Cluster Headache Survey comparing the clinical presentation of tobacco nonexposed and tobacco-exposed cluster headache patients. BACKGROUND: Cluster headache is uniquely tied to a personal history of tobacco usage/cigarette smoking and, if the individual cluster headache sufferer did not smoke, it has been shown that their parent(s) typically did and that individual had significant secondary smoke exposure as a child...
March 14, 2018: Headache
https://www.readbyqxmd.com/read/29520058/histone-deacetylases-mediate-gaba-a-receptor-expression-physiology-and-behavioral-maladaptations-in-rat-models-of-alcohol-dependence
#18
John Peyton Bohnsack, Benjamin A Hughes, Todd K O'Buckley, Kamyra Edokpolor, Joyce Besheer, A Leslie Morrow
Alcohol use disorders are chronic debilitating diseases characterized by severe withdrawal symptoms that contribute to morbidity and relapse. GABAA receptor (GABAA R) adaptations have long been implicated in the chronic effects of alcohol and contribute to many withdrawal symptoms associated with alcohol dependence. In rodents, GABAA R hypofunction results from decreases in Gabra1 expression, although the underlying mechanism controlling Gabra1 expression after chronic ethanol exposure is still unknown. We found that chronic ethanol exposure using either ethanol gavage or two-bottle choice voluntary access paradigms decreased Gabra1 expression and increased Hdac2 and Hdac3 expression...
February 27, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29515439/clinical-interpretations-of-patient-experience-in-a-trial-of-psilocybin-assisted-psychotherapy-for-alcohol-use-disorder
#19
Michael P Bogenschutz, Samantha K Podrebarac, Jessie H Duane, Sean S Amegadzie, Tara C Malone, Lindsey T Owens, Stephen Ross, Sarah E Mennenga
After a hiatus of some 40 years, clinical research has resumed on the use of classic hallucinogens to treat addiction. Following completion of a small open-label feasibility study, we are currently conducting a double-blind placebo-controlled clinical trial of psilocybin-assisted treatment of alcohol use disorder. Although treatment effects cannot be analyzed until the study is complete, descriptive case studies provide a useful window into the therapeutic process of psychedelic-assisted treatment of addiction...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29501676/validation-of-ethnopharmacology-of-ayurvedic-sarasvata-ghrita-and-comparative-evaluation-of-its-neuroprotective-effect-with-modern-alcoholic-and-lipid-based-extracts-in-%C3%AE-amyloid-induced-memory-impairment
#20
Madhuri Shelar, Sadhana Nanaware, S Arulmozhi, Sathiyanarayanan Lohidasan, Kakasaheb Mahadik
ETHNOPHARMACOLOGICAL RELEVANCE: Sarasvata ghrita (SG), a polyherbal formulation from ayurveda, an ancient medicinal system of India, has been used to improve intelligence and memory, treat speech delay, speaking difficulties and low digestion power in children. AIM OF THE STUDY: Study aimed to validate the ethno use of SG in memory enhancement through systematic scientific protocol. The effect of SG and modern extracts of ingredients of SG was compared on cognitive function and neuroprotection in amyloid-β peptide 25-35(Aβ25-35) induced memory impairment in wistar rats...
February 28, 2018: Journal of Ethnopharmacology
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