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https://www.readbyqxmd.com/read/28750942/a-standardized-extract-of-the-fruit-of-hovenia-dulcis-alleviated-alcohol-induced-hangover-in-healthy-subjects-with-heterozygous-aldh2-a-randomized-controlled-crossover-trial
#1
Hoejin Kim, You Jin Kim, Hye Yun Jeong, Ji Yeon Kim, Eun-Kyung Choi, Soo Wan Chae, Oran Kwon
ETHNOPHARMACOLOGICAL RELEVANCE: Hovenia dulcis, known as the oriental raisin tree, is mainly found in East Asia. It has long been used as traditional folk remedies for alcohol intoxication. AIM OF THE STUDY: To examine the anti-hangover effect of Hovenia dulcis Thunb. fruit extract (HDE) in a randomized controlled crossover trial. MATERIALS AND METHODS: Twenty-six eligible male adults with heterozygous ALDH2 (23.7±0.3 years old) consumed 360mL of Korean Soju (50g alcohol) together with HDE (2460mg) or matched placebo with subsequent crossover...
July 24, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28750479/the-impact-of-alcohol-hangover-symptoms-on-cognitive-and-physical-functioning-and-mood
#2
Marith van Schrojenstein Lantman, Marlou Mackus, Aurora J A E van de Loo, Joris C Verster
Hangover research often records the presence and severity of symptoms experienced the day after heavy alcohol consumption. However, usually no information is gathered on the impact of experiencing these symptoms on mood, cognition, and physical activities. An online survey was held among Dutch students, aged 18-30 years, who recently had a hangover. Overall hangover severity (i.e., a single 1-item rating) and the severity of 22 individual symptoms were rated on an 11-point scale ranging from 0 (absent) to 10 (extreme)...
July 27, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28728640/hangover-symptoms-heavy-episodic-drinking-and-depression-in-young-adults-a-cross-lagged-analysis
#3
Thomas M Piasecki, Constantine J Trela, Robin J Mermelstein
OBJECTIVE: The objective of this study was to examine associations between symptoms of alcohol hangover and depression, both cross-sectionally and prospectively. METHOD: Data were from a survey of young adults (N = 986, 60% female) initially recruited as part of an observational study of youth smoking. Participants reported past-year hangover symptoms, past-year frequency of heavy episodic drinking (HED), and past-week depression symptoms on two occasions separated by 1 year...
July 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28721110/total-sleep-time-alcohol-consumption-and-the-duration-and-severity-of-alcohol-hangover
#4
Marith van Schrojenstein Lantman, Marlou Mackus, Thomas Roth, Joris C Verster
INTRODUCTION: An evening of alcohol consumption often occurs at the expense of sleep time. The aim of this study was to determine the relationship between total sleep time and the duration and severity of the alcohol hangover. METHODS: A survey was conducted among Dutch University students to collect data on their latest alcohol hangover. Data on alcohol consumption, total sleep time, hangover severity, and duration were collected. Alcohol consumption and hangover severity and duration were compared for participants who (a) slept <5 hours, (b) slept between 5 and 7 hours, or (c) slept >7 hours...
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/28685869/biomarkers-of-the-alcohol-hangover-state-ethyl-glucuronide-etg-and-ethyl-sulfate-ets
#5
Marlou Mackus, Aurora J A E van de Loo, S Jorinde Raasveld, Anna Hogewoning, Javier Sastre Toraño, Frits M Flesch, Gerdien A H Korte-Bouws, Renier H P van Neer, Xiaochun Wang, Thomas T Nguyen, Karel A Brookhuis, Aletta D Kraneveld, Johan Garssen, Joris C Verster
INTRODUCTION: The aim of this study was to investigate the usefulness of ethyl glucuronide (EtG) and ethyl sulfate (EtS) as biomarkers of the hangover state. METHODS: Thirty-sixhealthy social drinkers participated in this study, being of naturalistic design. Eighteen participants experience regular hangovers (the hangover group), whereas the other 18 claim to not experience a hangover (the hangover-immune group). On a control day (alcohol-free) day and a post-alcohol day, urine EtG and EtS concentrations were determined and hangover severity assessed...
July 6, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28657424/heroin-piracetam-mixture-suggested-mechanisms-of-action-and-risks-of-misinterpretation-for-drug-users
#6
Simone Cappelletti, Francesco Lombardo, Pasquale Vitale, Giuseppe Vallone, Costantino Ciallella
Piracetam is a positive allosteric modulator of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor that has been frequently used in the treatment of cognitive disorders. Press and internet reports indicate that the use of piracetam, as a heroin adulterant, has spread rapidly in some countries, especially in Asia and Europe. Its use, as adulterant, is believed to produce more profound desirable effects, while decreasing hangover. Recent surveys demonstrated that piracetam protects neurons from heroin-induced apoptosis...
January 1, 2017: Medico-legal Journal
https://www.readbyqxmd.com/read/28616927/-technology-and-methodssimultaneous-determination-of-9-natural-ingredientsin-functional-food-for-anti-hangover-and-hepatoprotection-by-high-performance-liquid-chromatography
#7
Hai-Min Zou, Chen Zhou, Cheng-Jun Sun, Yong-Xin Li, Xiao-Song Yang, Jun Wen, Hong-Yan Zeng
OBJECTIVES: To develop a rapid method of high performance liquid chromatography coupled with variable wave length UV detection for simultaneous determination of 9 natural functional ingredients including puerarin, silymarin, quercetin hydrate, schisandrol A, curcumin, tanshinoneI, tanshinoneIIA, cryptotanshinone, and dihydrotanshinoneIin functional food for anti-hangover and hepatoprotection. METHODS: The samples were ultrasonically extracted with 90 % ethanol (V/V) and centrifuged at 10 000 r/min for 10 min prior to HPLC analysis...
May 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28568743/interventions-for-treatment-and-or-prevention-of-alcohol-hangover-systematic-review
#8
REVIEW
Ranil Jayawardena, Thulasika Thejani, Priyanga Ranasinghe, Dinithi Fernando, Joris C Verster
OBJECTIVE: To evaluate new research conducted over the past few years (2009-2016) assessing the effectiveness of potentially curative and/or preventive methods of alcohol hangover. METHODS: Data were retrieved by a 4-stage systematic search process. A search of the online Pubmed and Scopus databases were performed, using a combination of keywords: "Alcohol," "Ethanol," and "C2 H5 OH," in combination with the terms "Hangover," "Treatment," and "Prevention." The search comprised studies listed between January 1, 2009 and June 30, 2016...
May 31, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28462133/effects-of-the-herb-mixture-dts20-on-oxidative-stress-and-plasma-alcoholic-metabolites-after-alcohol-consumption-in-healthy-young-men
#9
Yang Hee Hong
BACKGROUND: This study was designed to investigate the effect of a herbal mixture extract (DTS20) on the attenuation of oxidative stress and hangover after alcohol consumption in healthy volunteers. METHODS: DTS20 consists of Viscum album L. (40%), Lycium chinense L. (30%), Inonotus obliquus (20%), and Acanthopanax senticosus H. (10%). We recruited healthy, nonsmoking, adult men volunteers aged between 21 years and 30 years to participate in a crossover trial. Twenty participants received either one package of placebo with 200 mL water or DTS20 with 200 mL water...
December 2016: Integrative medicine research
https://www.readbyqxmd.com/read/28450149/free-radical-production-and-antioxidant-status-in-brain-cortex-non-synaptic-mitochondria-and-synaptosomes-at-alcohol-hangover-onset
#10
Analía G Karadayian, Gabriela Malanga, Analía Czerniczyniec, Paulina Lombardi, Juanita Bustamante, Silvia Lores-Arnaiz
Alcohol hangover (AH) is the pathophysiological state after a binge-like drinking. We have previously demonstrated that AH induced bioenergetics impairments in a total fresh mitochondrial fraction in brain cortex and cerebellum. The aim of this work was to determine free radical production and antioxidant systems in non-synaptic mitochondria and synaptosomes in control and hangover animals. Superoxide production was not modified in non-synaptic mitochondria while a 17.5% increase was observed in synaptosomes...
April 24, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28414020/modifying-alcohol-consumption-to-reduce-obesity-macro-development-and-feasibility-trial-of-a-complex-community-based-intervention-for-men
#11
Iain K Crombie, Kathryn B Cunningham, Linda Irvine, Brian Williams, Falko F Sniehotta, John Norrie, Ambrose Melson, Claire Jones, Andrew Briggs, Peter M Rice, Marcus Achison, Andrew McKenzie, Elena Dimova, Peter W Slane
BACKGROUND: Obese men who consume alcohol are at a greatly increased risk of liver disease; those who drink > 14 units of alcohol per week have a 19-fold increased risk of dying from liver disease. OBJECTIVES: To develop an intervention to reduce alcohol consumption in obese men and to assess the feasibility of a randomised controlled trial (RCT) to investigate its effectiveness. DESIGN OF THE INTERVENTION: The intervention was developed using formative research, public involvement and behaviour change theory...
April 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28412921/synthetic-cannabinoids-psychopharmacology-clinical-aspects-and-psy-chotic-onset
#12
Giovanni Martinotti, Rita Santacroce, Duccio Papanti, Yasmine Elgharably, Mariya Prilutskaya, Ornella Corazza
Synthetic Cannabinoids (SC) are the widest and most diffused class of Novel Psychoactive Substances. SC are chemically heterogeneous and structurally dissimilar from delta-9-tetrahydrocannabinol, being full agonists of the endocannabinoid system receptors CB1 and CB2. Desired effects include euphoria, talkativeness, feelings of joy and laughter, relaxation. With respect to cannabis, SC intake may also be associated with quicker arise of the effects, shorter duration of action, and larger levels of hangover...
April 13, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28375694/cocktail-without-hangover-in-search-for-the-optimal-chemotherapy-in-the-combined-management-of-non-operable-esophageal-carcinomas
#13
Bianca So, Loredana G Marcu, Ian Olver, Raghu Gowda, Eva Bezak
BACKGROUND: The worldwide incidence of esophageal cancer has greatly increased over the past few decades making it the sixth deadliest cancer. The disease is often detected in advanced stages when surgery is no longer an option. The standard treatment in these situations is combined chemoradiotherapy, by employing drug cocktails that lead to optimal treatment outcomes both from the perspective of tumor control and normal tissue toxicity. METHODS: The aim of this work was to collate the existing trials and clinical studies reported on non-operable esophageal cancer and to analyze the results based on treatment outcomes after various drug combinations...
April 4, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28330787/acute-impact-of-caffeinated-alcoholic-beverages-on-cognition-a-systematic-review
#14
REVIEW
Laurence Lalanne, Pierre-Eric Lutz, François Paille
INTRODUCTION: Energy drinks are popular beverages that are supposed to counteract sleepiness, increase energy, maintain alertness and reduce symptoms of hangover. Cognitive enhancing seems to be related to many compounds such as caffeine, taurine and vitamins. Currently, users mostly combine psychostimulant effects of energy drinks to counteract sedative effects of alcohol. However, recent literature suggests that this combination conducts to feel less intoxicated but still impaired. The goal of the present article is to review cognitive impact and subjective awareness in case of caffeinated alcoholic beverage (CAB) intoxication...
March 19, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28303371/does-familial-risk-for-alcohol-use-disorder-predict-alcohol-hangover
#15
Richard Stephens, Kara Holloway, James A Grange, Lauren Owen, Kate Jones, Darren Kruisselbrink
AIMS: Positive family history of alcohol use disorder (FHP), a variable associated with propensity for alcohol use disorder (AUD), has been linked with elevated hangover frequency and severity, after controlling for alcohol use. This implies that hangover experiences may be related to AUD. However, inadequate control of alcohol consumption levels, low alcohol dose and testing for hangover during the intoxication phase detract from these findings. Here, we present further data pertinent to understanding the relationship between family history and alcohol hangover...
June 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28262186/urine-methanol-concentration-and-alcohol-hangover-severity
#16
M Mackus, A J A E Van de Loo, G A H Korte-Bouws, R H P Van Neer, X Wang, T T Nguyen, K A Brookhuis, J Garssen, J C Verster
BACKGROUND: Congeners are substances, other than ethanol, that are produced during fermentation. Previous research found that the consumption of congener-rich drinks contributes to the severity of alcohol hangover. Methanol is such a congener that has been related to alcohol hangover. Therefore, the aim of this study was to examine the relationship between urine methanol concentration and alcohol hangover severity. METHODS: N = 36 healthy social drinkers (22 females, 14 males), aged 18-30 years old, participated in a naturalistic study, comprising a hangover day and a control day (no alcohol consumed the previous day)...
March 2017: Alcohol
https://www.readbyqxmd.com/read/28215179/development-of-a-definition-for-the-alcohol-hangover-consumer-descriptions-and-expert-consensus
#17
Marith Van Schrojenstein Lantman, A J A E van de Loo, Marlou Mackus, Joris C Verster
Up to now there is no adequate definition of the alcohol hangover. The purpose of the current study was to develop a useful definition, and consensus among those who will use it in scientific publications. A survey was conducted among N=1099 social drinkers who recently had a hangover. They were asked to provide their definition of the alcohol hangover. Text mining and content analysis revealed 3 potential definitions. These were submitted to members of the Alcohol Hangover Research Group, who were asked to give their expert opinion on the proposed definitions...
February 16, 2017: Current Drug Abuse Reviews
https://www.readbyqxmd.com/read/28178589/the-breathtaking-truth-about-breath-alcohol-readings-of-zero
#18
Joris C Verster, Marlou Mackus, Aurora Jae van de Loo, Johan Garssen, Andrew Scholey
INTRODUCTION: It has been postulated that the hangover state starts when breath alcohol concentration is zero. METHODS: Data from 2 studies that assessed ethanol in breath, blood and urine were compared. RESULTS: The data revealed that ethanol may still be present in the blood and urine during the hangover state, despite breath analyser readings of zero. DISCUSSION: As ethanol is still present in the body despite zero breath alcohol readings, the current consensus to postpone cognitive testing in hangover studies until breath alcohol concentration is zero should be reconsidered...
January 21, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28176621/a-review-of-the-physiological-factors-associated-with-alcohol-hangover
#19
Celeste Tipple, Sarah Michelle Benson, Andrew Scholey
Alcohol hangovers are a commonly experienced consequence of drinking and are frequently associated with worsened mood and cognitive functioning. The physiological changes that occur with an alcohol-induced hangover state are largely unknown. This review focuses on key physiological factors of an alcohol-induced hangover, more specifically, oxidative stress, lack of sleep, hormonal fluctuations, dehydration, headaches, fever and changes to the immune system. Increased understanding of the relationship between the physiological factors and symptoms of a hangover is needed to further elucidate the mechanisms of an alcohol-induced hangover and potentially identify a treatment...
February 7, 2017: Current Drug Abuse Reviews
https://www.readbyqxmd.com/read/28093029/low-doses-of-mirtazapine-or-quetiapine-for-transient-insomnia-a-randomised-double-blind-cross-over-placebo-controlled-trial
#20
Julie Karsten, Loes A Hagenauw, Jeanine Kamphuis, Marike Lancel
Low doses of the antidepressant mirtazapine or the neuroleptic quetiapine are often prescribed off-label for insomnia. However, studies on the effects on sleep and hangover effects the following day are scarce. In this randomised, double-blind, cross-over, placebo-controlled trial, the influence of 7.5 mg mirtazapine and 50 mg quetiapine on both normal sleep and sleep disturbed by acoustic stress (traffic noise) as a model for transient insomnia was assessed. Additionally, hangover effects on next-day alertness and cognitive functioning were examined...
March 2017: Journal of Psychopharmacology
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