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https://www.readbyqxmd.com/read/29303084/proceeding-of-the-9th-alcohol-hangover-research-group-meeting
#1
Joirs C Verster, Agnese Merlo, Sally Adams, Sarah Benson, Lydia Devenney, Craig Gunn, Jacqueline Iversen, Sean J Johnson, Marlou Mackus, Andrew Scholey, Ann-Kathrin Stock, Aurora J A E van de Loo, Marith van Schrojenstein Lantman, Livia J F Wilod Versprille
Alcohol hangover is a common occurrence among individuals who have experienced an episode of heavy alcohol consumption the previous night. Until now defined as the general feeling of misery that develops once the Blood Alcohol Concentration approaches zero. Despite its prevalence and several related adverse consequences, insufficient research has been conducted with regards to this matter and further understanding of the pathology of alcohol hangover is necessary. During the 9th Alcohol Hangover Research Group meeting, held on April 29th 2017, Utrecht, The Netherlands, numerous aspects of alcohol hangover were presented and many advances with regards to determinants, biological and cognitive consequences and potential treatment have been presented...
January 4, 2018: Current Drug Abuse Reviews
https://www.readbyqxmd.com/read/29260703/-a-randomized-single-blinded-study-of-the-effect-of-intake-of-repair-beer-during-a-hangover
#2
Jacob P Hartmann, Morten Toft Lund
We conducted a randomized, single-blinded study of the effect of alcohol intake during a hangover. We measured cardiovascular parameters, and the participants filled out a series of questionnaires regarding their well-being. We found, that an intake of five beers led to a significant decrease in systolic blood pressure, heart rate and self-reported feeling of palpitations. However, the self-reported sense of well-being did not improve. In addition, we found that the risk of brain freeze increased, as the beer's temperature fell...
December 11, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29216570/the-effects-of-alcohol-hangover-on-future-drinking-behavior-and-the-development-of-alcohol-problems
#3
Kelly E Courtney, Matthew Worley, Norma Castro, Susan F Tapert
INTRODUCTION: Alcohol hangover experiences in young adulthood have been shown to predict more subsequent alcohol problems. Hangover susceptibility appears to be partially heritable and related to family history of alcohol use disorders. However, very little is known about the developmental course of these associations and whether they are accounted for by an individual's drinking history. The goal of this study is to investigate the prospective and unique relationships between family history of alcohol use disorders, severity of alcohol hangover experiences in adolescence, and later alcohol use and related problems measured over 13years...
November 28, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29216206/the-psychometric-properties-of-a-shortened-dutch-version-of-the-consequences-scale-used-in-the-core-alcohol-and-drug-survey
#4
Sara De Bruyn, Edwin Wouters, Koen Ponnet, Joris Van Damme, Guido Van Hal
BACKGROUND: Alcohol and drug misuse among college students has been studied extensively and has been clearly identified as a public health problem. Within more general populations alcohol misuse remains one of the leading causes of disease, disability and death worldwide. Conducting research on alcohol misuse requires valid and reliable instruments to measure its consequences. One scale that is often used is the consequences scale in the Core Alcohol and Drug Survey (CADS). However, psychometric studies on the CADS are rare and the ones that do exist report varying results...
2017: PloS One
https://www.readbyqxmd.com/read/29211818/susceptibility-to-alcohol-hangovers-not-just-a-matter-of-being-resilient
#5
Marith van Schrojenstein Lantman, Aurora J A E van de Loo, Marlou Mackus, Aletta D Kraneveld, Karel A Brookhuis, Johan Garssen, Joris C Verster
Introduction: Although most drinkers have experienced a hangover the day following heavy alcohol consumption, a minority claims to be hangover resistant despite consuming the same large quantities of alcohol as those reporting alcohol hangover. The aim of the current study was to examine if susceptibility to experiencing hangovers is related to a drinker's interpretation of wellbeing and psychological assets to bounce back. Methods: A survey was conducted among 2295 Dutch students assessing their past month alcohol consumption patterns, and measuring mental resilience and wellbeing...
December 4, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29196951/behavioral-and-biochemical-effects-of-n-acetylcysteine-in-zebrafish-acutely-exposed-to-ethanol
#6
Ricieri Mocelin, Matheus Marcon, Simone D'ambros, Ana P Herrmann, Alex Sander da Rosa Araujo, Angelo Piato
Alcohol hangover refers to unpleasant symptoms experienced as a direct consequence of a binge drinking episode. The effects observed in this condition are related to the increase in alcohol metabolites and imbalance in oxidative status. N-acetylcysteine (NAC) is a mucolytic agent and an antidote for paracetamol overdose. Preclinical and clinical studies have shown that NAC is a multi-target drug acting through neuroprotective, antioxidant and neurotrophic mechanisms as well as a glutamate modulator. The aim of this study was to investigate the effects of NAC in zebrafish acutely exposed to ethanol (EtOH)...
December 1, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28839374/hepatoprotective-flavonoids-in-opuntia-ficus-indica-fruits-by-reducing-oxidative-stress-in-primary-rat-hepatocytes
#7
Jung Wha Kim, Tae Bum Kim, Hyun Woo Kim, Sang Wook Park, Hong Pyo Kim, Sang Hyun Sung
BACKGROUND: Liver disorder was associated with alcohol consumption caused by hepatic cellular damages. Opuntia ficus-indica fruit extracts (OFIEs), which contain betalain pigments and polyphenols including flavonoids, have been introduced as reducing hangover symptoms and liver protective activity. OBJECTIVE: To evaluate hepatoprotective activity of OFIEs and isolated compounds by high-speed countercurrent chromatography (HSCCC). MATERIALS AND METHODS: The extract of O...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28750942/a-standardized-extract-of-the-fruit-of-hovenia-dulcis-alleviated-alcohol-induced-hangover-in-healthy-subjects-with-heterozygous-aldh2-a-randomized-controlled-crossover-trial
#8
Hoejin Kim, You Jin Kim, Hye Yun Jeong, Ji Yeon Kim, Eun-Kyung Choi, Soo Wan Chae, Oran Kwon
ETHNOPHARMACOLOGICAL RELEVANCE: Hovenia dulcis, known as the oriental raisin tree, is mainly found in East Asia. It has long been used as traditional folk remedies for alcohol intoxication. AIM OF THE STUDY: To examine the anti-hangover effect of Hovenia dulcis Thunb. fruit extract (HDE) in a randomized controlled crossover trial. MATERIALS AND METHODS: Twenty-six eligible male adults with heterozygous ALDH2 (23.7±0.3 years old) consumed 360mL of Korean Soju (50g alcohol) together with HDE (2460mg) or matched placebo with subsequent crossover...
September 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28750479/the-impact-of-alcohol-hangover-symptoms-on-cognitive-and-physical-functioning-and-mood
#9
Marith van Schrojenstein Lantman, Marlou Mackus, Aurora J A E van de Loo, Joris C Verster
Hangover research often records the presence and severity of symptoms experienced the day after heavy alcohol consumption. However, usually no information is gathered on the impact of experiencing these symptoms on mood, cognition, and physical activities. An online survey was held among Dutch students, aged 18-30 years, who recently had a hangover. Overall hangover severity (i.e., a single 1-item rating) and the severity of 22 individual symptoms were rated on an 11-point scale ranging from 0 (absent) to 10 (extreme)...
September 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28728640/hangover-symptoms-heavy-episodic-drinking-and-depression-in-young-adults-a-cross-lagged-analysis
#10
Thomas M Piasecki, Constantine J Trela, Robin J Mermelstein
OBJECTIVE: The objective of this study was to examine associations between symptoms of alcohol hangover and depression, both cross-sectionally and prospectively. METHOD: Data were from a survey of young adults (N = 986, 60% female) initially recruited as part of an observational study of youth smoking. Participants reported past-year hangover symptoms, past-year frequency of heavy episodic drinking (HED), and past-week depression symptoms on two occasions separated by 1 year...
July 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28721110/total-sleep-time-alcohol-consumption-and-the-duration-and-severity-of-alcohol-hangover
#11
Marith van Schrojenstein Lantman, Marlou Mackus, Thomas Roth, Joris C Verster
INTRODUCTION: An evening of alcohol consumption often occurs at the expense of sleep time. The aim of this study was to determine the relationship between total sleep time and the duration and severity of the alcohol hangover. METHODS: A survey was conducted among Dutch University students to collect data on their latest alcohol hangover. Data on alcohol consumption, total sleep time, hangover severity, and duration were collected. Alcohol consumption and hangover severity and duration were compared for participants who (a) slept <5 hours, (b) slept between 5 and 7 hours, or (c) slept >7 hours...
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/28685869/biomarkers-of-the-alcohol-hangover-state-ethyl-glucuronide-etg-and-ethyl-sulfate-ets
#12
Marlou Mackus, Aurora J A E van de Loo, S Jorinde Raasveld, Anna Hogewoning, Javier Sastre Toraño, Frits M Flesch, Gerdien A H Korte-Bouws, Renier H P van Neer, Xiaochun Wang, Thomas T Nguyen, Karel A Brookhuis, Aletta D Kraneveld, Johan Garssen, Joris C Verster
INTRODUCTION: The aim of this study was to investigate the usefulness of ethyl glucuronide (EtG) and ethyl sulfate (EtS) as biomarkers of the hangover state. METHODS: Thirty-sixhealthy social drinkers participated in this study, being of naturalistic design. Eighteen participants experience regular hangovers (the hangover group), whereas the other 18 claim to not experience a hangover (the hangover-immune group). On a control day (alcohol-free) day and a post-alcohol day, urine EtG and EtS concentrations were determined and hangover severity assessed...
September 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28657424/heroin-piracetam-mixture-suggested-mechanisms-of-action-and-risks-of-misinterpretation-for-drug-users
#13
Simone Cappelletti, Francesco Lombardo, Pasquale Vitale, Giuseppe Vallone, Costantino Ciallella
Piracetam is a positive allosteric modulator of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor that has been frequently used in the treatment of cognitive disorders. Press and internet reports indicate that the use of piracetam, as a heroin adulterant, has spread rapidly in some countries, especially in Asia and Europe. Its use, as adulterant, is believed to produce more profound desirable effects, while decreasing hangover. Recent surveys demonstrated that piracetam protects neurons from heroin-induced apoptosis...
January 1, 2017: Medico-legal Journal
https://www.readbyqxmd.com/read/28616927/-technology-and-methodssimultaneous-determination-of-9-natural-ingredientsin-functional-food-for-anti-hangover-and-hepatoprotection-by-high-performance-liquid-chromatography
#14
Hai-Min Zou, Chen Zhou, Cheng-Jun Sun, Yong-Xin Li, Xiao-Song Yang, Jun Wen, Hong-Yan Zeng
OBJECTIVES: To develop a rapid method of high performance liquid chromatography coupled with variable wave length UV detection for simultaneous determination of 9 natural functional ingredients including puerarin, silymarin, quercetin hydrate, schisandrol A, curcumin, tanshinoneI, tanshinoneIIA, cryptotanshinone, and dihydrotanshinoneIin functional food for anti-hangover and hepatoprotection. METHODS: The samples were ultrasonically extracted with 90 % ethanol (V/V) and centrifuged at 10 000 r/min for 10 min prior to HPLC analysis...
May 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28568743/interventions-for-treatment-and-or-prevention-of-alcohol-hangover-systematic-review
#15
REVIEW
Ranil Jayawardena, Thulasika Thejani, Priyanga Ranasinghe, Dinithi Fernando, Joris C Verster
OBJECTIVE: To evaluate new research conducted over the past few years (2009-2016) assessing the effectiveness of potentially curative and/or preventive methods of alcohol hangover. METHODS: Data were retrieved by a 4-stage systematic search process. A search of the online Pubmed and Scopus databases were performed, using a combination of keywords: "Alcohol," "Ethanol," and "C2 H5 OH," in combination with the terms "Hangover," "Treatment," and "Prevention." The search comprised studies listed between January 1, 2009 and June 30, 2016...
May 31, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28462133/effects-of-the-herb-mixture-dts20-on-oxidative-stress-and-plasma-alcoholic-metabolites-after-alcohol-consumption-in-healthy-young-men
#16
Yang Hee Hong
BACKGROUND: This study was designed to investigate the effect of a herbal mixture extract (DTS20) on the attenuation of oxidative stress and hangover after alcohol consumption in healthy volunteers. METHODS: DTS20 consists of Viscum album L. (40%), Lycium chinense L. (30%), Inonotus obliquus (20%), and Acanthopanax senticosus H. (10%). We recruited healthy, nonsmoking, adult men volunteers aged between 21 years and 30 years to participate in a crossover trial. Twenty participants received either one package of placebo with 200 mL water or DTS20 with 200 mL water...
December 2016: Integrative Medicine Research
https://www.readbyqxmd.com/read/28450149/free-radical-production-and-antioxidant-status-in-brain-cortex-non-synaptic-mitochondria-and-synaptosomes-at-alcohol-hangover-onset
#17
Analía G Karadayian, Gabriela Malanga, Analía Czerniczyniec, Paulina Lombardi, Juanita Bustamante, Silvia Lores-Arnaiz
Alcohol hangover (AH) is the pathophysiological state after a binge-like drinking. We have previously demonstrated that AH induced bioenergetics impairments in a total fresh mitochondrial fraction in brain cortex and cerebellum. The aim of this work was to determine free radical production and antioxidant systems in non-synaptic mitochondria and synaptosomes in control and hangover animals. Superoxide production was not modified in non-synaptic mitochondria while a 17.5% increase was observed in synaptosomes...
April 24, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28414020/modifying-alcohol-consumption-to-reduce-obesity-macro-development-and-feasibility-trial-of-a-complex-community-based-intervention-for-men
#18
RANDOMIZED CONTROLLED TRIAL
Iain K Crombie, Kathryn B Cunningham, Linda Irvine, Brian Williams, Falko F Sniehotta, John Norrie, Ambrose Melson, Claire Jones, Andrew Briggs, Peter M Rice, Marcus Achison, Andrew McKenzie, Elena Dimova, Peter W Slane
BACKGROUND: Obese men who consume alcohol are at a greatly increased risk of liver disease; those who drink > 14 units of alcohol per week have a 19-fold increased risk of dying from liver disease. OBJECTIVES: To develop an intervention to reduce alcohol consumption in obese men and to assess the feasibility of a randomised controlled trial (RCT) to investigate its effectiveness. DESIGN OF THE INTERVENTION: The intervention was developed using formative research, public involvement and behaviour change theory...
April 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28412921/synthetic-cannabinoids-psychopharmacology-clinical-aspects-and-psy-chotic-onset
#19
Giovanni Martinotti, Rita Santacroce, Duccio Papanti, Yasmine Elgharably, Mariya Prilutskaya, Ornella Corazza
Synthetic Cannabinoids (SC) are the widest and most diffused class of Novel Psychoactive Substances. SC are chemically heterogeneous and structurally dissimilar from delta-9-tetrahydrocannabinol, being full agonists of the endocannabinoid system receptors CB1 and CB2. Desired effects include euphoria, talkativeness, feelings of joy and laughter, relaxation. With respect to cannabis, SC intake may also be associated with quicker arise of the effects, shorter duration of action, and larger levels of hangover...
April 13, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28375694/cocktail-without-hangover-in-search-for-the-optimal-chemotherapy-in-the-combined-management-of-non-operable-esophageal-carcinomas
#20
Bianca So, Loredana G Marcu, Ian Olver, Raghu Gowda, Eva Bezak
BACKGROUND: The worldwide incidence of esophageal cancer has greatly increased over the past few decades making it the sixth deadliest cancer. The disease is often detected in advanced stages when surgery is no longer an option. The standard treatment in these situations is combined chemoradiotherapy, by employing drug cocktails that lead to optimal treatment outcomes both from the perspective of tumor control and normal tissue toxicity. METHODS: The aim of this work was to collate the existing trials and clinical studies reported on non-operable esophageal cancer and to analyze the results based on treatment outcomes after various drug combinations...
April 4, 2017: Acta Oncologica
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