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JOURNAL ARTICLE
Young Hoon Song, Hye Min Cho, Yeong Chae Ryu, Byeong Hee Hwang, Jeong Hyun Seo
In this study, we synthesized levan shell hydrophobic silica nanoclusters encapsulating doxorubicin (L-HSi-Dox) and evaluated their potential as ultrasound-responsive drug delivery systems for cancer treatment. L-HSi-Dox nanoclusters were successfully fabricated by integrating a hydrophobic silica nanoparticle-doxorubicin complex as the core and an amphiphilic levan carbohydrate polymer as the shell by using an electrospray technique. Characterization analyses confirmed the stability, size, and composition of the nanoclusters...
April 20, 2024: ACS Applied Materials & Interfaces
#2
JOURNAL ARTICLE
Chryso Th Pallari, Souzana Achilleos, Annalisa Quattrocchi, John Gabel, Elena Critselis, Maria Athanasiadou, Mohammad Reza Rahmanian Haghighi, Stefania Papatheodorou, Tianyu Liu, Andreas Artemiou, Jose M Rodriguez-Llanes, Catherine M Bennett, Claudia Zimmermann, Eva Schernhammer, Natalia Bustos Sierra, Reindert Ekelson, Jackeline Lobato, Laylla Macedo, Laust Hvas Mortensen, Julia Critchley, Lucy Goldsmith, Gleb Denissov, Nolwenn Le Meur, Levan Kandelaki, Kostas Athanasakis, Binyamin Binyaminy, Tamar Maor, Fabrizio Stracci, Giuseppe Ambrosio, Kairat Davletov, Nataliya Glushkova, Cyndy Martial, Marie Chan Sun, Terje P Hagen, Mario Chong, Manuel Barron, Błażej Łyszczarz, Ivan Erzen, Pedro Arcos Gonzalez, Bo Burström, Nataliia Pidmurniak, Olesia Verstiuk, Qian Huang, Antonis Polemitis, Andreas Charalambous, Christiana A Demetriou
INTRODUCTION: To examine the impact of the COVID-19 pandemic on mortality, we estimated excess all-cause mortality in 24 countries for 2020 and 2021, overall and stratified by sex and age. METHODS: Total, age-specific and sex-specific weekly all-cause mortality was collected for 2015-2021 and excess mortality for 2020 and 2021 was calculated by comparing weekly 2020 and 2021 age-standardised mortality rates against expected mortality, estimated based on historical data (2015-2019), accounting for seasonality, and long-term and short-term trends...
April 18, 2024: BMJ Global Health
#3
JOURNAL ARTICLE
Ilaria Finore, Giovanni Dal Poggetto, Luigi Leone, Andrea Cattaneo, Barbara Immirzi, Maria Michela Corsaro, Angela Casillo, Annarita Poli
Pseudomonas strain 2ASCA isolated in subarctic Québec, Canada, produced a cell membrane bound levan-type exopolymer (yield 1.17 g/L), after incubation in growth media containing 6 % sucrose (w/v) at temperature of 15 °C for 96 h. The objective of this study was to optimize levan production by varying the growth parameters. Moreover, polymer chemical characterization has been studied with the aim of increasing knowledge and leading to future applications in many fields, including heavy metal remediation...
April 16, 2024: International Journal of Biological Macromolecules
#4
JOURNAL ARTICLE
Rui Han, Melanie Baudrexl, Christina Ludwig, Oksana V Berezina, Sergey V Rykov, Wolfgang Liebl
A new strain of xanthan-degrading bacteria identified as Cohnella sp. has been isolated from a xanthan thickener for food production. The strain was able to utilize xanthan as the only carbon source and to reduce the viscosity of xanthan-containing medium during cultivation. Comparative analysis of the secretomes of Cohnella sp. after growth on different media led to the identification of a xanthanase designated as Csp Xan9, which was isolated after recombinant production in Escherichia coli . Csp Xan9 could efficiently degrade the β-1,4-glucan backbone of xanthan after previous removal of pyruvylated mannose residues from the ends of the native xanthan side chains by xanthan lyase treatment (XLT-xanthan)...
2024: Frontiers in Microbiology
#5
JOURNAL ARTICLE
Reun-Ping Goh, Shin Lee, Zi-Qing Fang, Wen-Chien Tang, Chia-Ching Chu
Pocketbook plants ( Calceolaria spp.) are flowering ornamentals often grown as potted plants (Poesch 1937). In December 2022, leaf blight symptoms were observed on 2-mo-old plants of C . hybrida F1 'Dainty'. The disease was found in a nursery in Ren'ai Township, Nantou, and about 20% of the plants exhibited symptoms. Symptomatic plants had brown or gray necrotic lesions of different sizes and shapes, mostly around leaf margins. Lower leaf wilting was also observed (Fig. S1, A and B). Three plants were sampled...
April 8, 2024: Plant Disease
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JOURNAL ARTICLE
Verena Hassler, Nele Brand, Daniel Wefers
Kombucha is prepared by fermenting sugared green or black tea with a symbiotic culture of bacteria and yeast (SCOBY). Some of the bacteria within the SCOBY are known to form exopolysaccharides (EPS) from sucrose. However, it is yet unknown whether EPS are formed in kombucha, and if so, which specific EPS are present. Therefore, different kombucha samples were prepared by fermentation of green and black tea with SCOBYs from different manufacturers. Subsequently, the EPS were isolated and characterized by using various chromatographic methods, partial enzymatic hydrolyses and NMR spectroscopy...
April 5, 2024: International Journal of Biological Macromolecules
#7
JOURNAL ARTICLE
Yaqian Chen, Jinfeng Wu, Changrui Ma, Dawei Zhang, Dinggang Zhou, Jihong Zhang, Mingli Yan
Seed germination is an important development process in plant growth. The phytohormone abscisic acid (ABA) plays a critical role during seed germination. However, the mechanism of rapeseed in response to ABA is still elusive. In order to understand changes of rapeseed under exogenous ABA treatment, we explored differentially expressed metabolites (DEMs) and the differentially expressed genes (DEGs) between mock- and ABA-treated seedlings. A widely targeted LC-MS/MS based metabolomics were used to identify and quantify metabolic changes in response to ABA during seed germination, and a total of 186 significantly DEMs were identified...
April 5, 2024: BMC Plant Biology
#8
JOURNAL ARTICLE
Phaniendra Alugoju, Tewin Tencomnao
Levan is a fructose-based biopolymer with diverse applications in medicinal, pharmaceutical, and food industries. However, despite its extensive biological and pharmacological actions, including antioxidant, anti-inflammatory, and antidiabetic properties, research on its anti-aging potential is limited. This study explored levan's impact on chronological lifespan (CLS) of yeast Saccharomyces cerevisiae for the first time. The results show that levan treatment significantly extended the CLS of wild-type (WT) yeast by preventing the accumulation of oxidative stress markers (reactive oxygen species, malondialdehyde, and protein carbonyl content) and ameliorating apoptotic features such as reduced mitochondrial membrane potential, loss of plasma membrane integrity, and externalization of phosphatidylserine...
April 2, 2024: International Journal of Biological Macromolecules
#9
JOURNAL ARTICLE
Nabin B Khanal, Levan Elbakidze
We examined the spatial distribution of Per- and Polyfluoroalkyl Substances (PFAS) in the US drinking water and explored the relationship between PFAS contamination, public water systems (PWS) characteristics, and socioeconomic attributes of the affected communities. Using data from the EPA's third Unregulated Contaminant Rule, the Census Bureau, and the Bureau of Labor Statistics, we identified spatial contamination hot spots and found that PFAS contamination was correlated with PWSs size, non-surface raw water intake sources, population, and housing density...
2024: PloS One
#10
JOURNAL ARTICLE
Juanit Thomas, Payel Roy, Arabinda Ghosh, Megha Mete, Samir Kumar Sil, Deeplina Das
The global demand for therapeutic prebiotics persuades the quest for novel exopolysaccharides that can retard the growth of pathobionts and healthcare-associated pathogens. In this regard, an exopolysaccharide (3.69 mg/mL) producing strain showing prebiotic and antibiofilm activity was isolated from indigenous pineapple pomace of Tripura and identified as Bacillus subtilis PR-C18. Zymogram analysis revealed EPS PR-C18 was synthesized by levansucrase (∼57 kDa) with a maximal activity of 4.62 U/mg...
March 23, 2024: Carbohydrate Research
#11
JOURNAL ARTICLE
Levan B Berikashvili, Mikhail Ya Yadgarov, Artem N Kuzovlev, Anastasia V Smirnova, Kristina K Kadantseva, Ivan V Kuznetsov, Petr A Polyakov, Valery V Likhvantsev
OBJECTIVES: The quality of postoperative analgesia in total knee arthroplasty is crucial for patient recovery, rehabilitation and hospital stay duration. In line with the above, а single-shot adductor canal block has been considered as surpassing method over continuous femoral nerve block. However, continuous adductor canal block and single-shot femoral nerve block 'kept overboard' the discussion. This study aims to compare the effectiveness of various types of adductor and femoral nerve blocks on clinically relevant outcomes in patients following total knee arthroplasty...
April 2, 2024: Clinical Journal of Pain
#12
JOURNAL ARTICLE
Mariusz Trybus, Levan Chotorlishvili, Elżbieta Jartych
In our studies, we combined two powdered materials, i.e., ferroelectric triglycine sulfate (TGS) and ferrimagnetic magnetite Fe3 O4 , to obtain a magnetoelectric composite. The ferroelectric (E) part, i.e., TGS, was a hybrid organic-inorganic crystal, which we obtained as a pure single crystal from an aqueous solution using a static water evaporation method. The magnetic (M) part of the composite was commercially available magnetite. The samples used for the dielectric and magnetoelectric measurements were cold-pressed and made in the form of a circular tablet...
March 20, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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JOURNAL ARTICLE
George A Rublev, Levan Natchkebia, Vazha Gaprindashvili, Mohamed Ahmed Mohamed, Tamaz Tamazishvili, Irakli Kartozia, Mikheil Zimlitski
PURPOSE: To evaluate the experiences and outcomes of arthroscopic partial meniscectomy in symptomatic non-Wrisberg discoid lateral meniscus in children younger than 12 years old at a single center. METHODS: We retrospectively reviewed the medical records of all pediatric patients who were treated for non-Wrisberg discoid meniscus at our institute between 2013 and 2021. Patients were separated into 2 groups: Patients who underwent partial resection with saucerization (group A) or patients who underwent saucerization, tear repair, and fixation (group B)...
April 2024: Arthroscopy, sports medicine, and rehabilitation
#14
JOURNAL ARTICLE
Matija Svetina, Marko Perkovič, Chuanyong Yang, Yuan Gu, Aleks Mindadze, Natia Mikeltadze, Levan Davitadze, George Gabedava
The main objective of the present study was to investigate factors related to seafarers' mental health. A sample of seafarers from 12 countries participated in the study. A list of stressors was used to assess both perception of exposure to these stressors and their subjective significance. The Symptom Checklist (SCL-90) was used to assess seafarers' mental health on 5 of 9 subscales: Depression, Anxiety, Hostility, Interpersonal Sensitivity, and Somatisation. Three significant findings emerged from the analyses...
2024: Inquiry: a Journal of Medical Care Organization, Provision and Financing
#15
Gözde Koşarsoy Ağçeli
No abstract text is available yet for this article.
March 23, 2024: International Journal of Biological Macromolecules
#16
Mina Ghaly, Alyssa Zakala, Kavya Penmethsa, Kristy D Johnson-Pich
Pantoea , a gram-negative, rod-shaped, anaerobic bacterium, is a rare cause of human disease. Pantoea species have been known to mostly cause pulmonary disease in agricultural workers as they are native to select crops and wild animal furs. However, in very few documented cases, Pantoea has been discovered as the source of nosocomial infections, usually in the setting of an immunocompromised host. This case report details the clinical course of a 62-year-old immunocompromised female with stage 3 breast cancer presenting with acute cholecystitis and bacteremia and the unexpected discovery of Pantoea in peripheral and chemotherapy port blood cultures...
February 2024: Curēus
#17
JOURNAL ARTICLE
Mariana González-Torres, Francisco Hernández-Rosas, Neith Pacheco, Josafhat Salinas-Ruiz, José A Herrera-Corredor, Ricardo Hernández-Martínez
The valorization of byproducts from the sugarcane industry represents a potential alternative method with a low energy cost for the production of metabolites that are of commercial and industrial interest. The production of exopolysaccharides (EPSs) was carried out using the yeast Suhomyces kilbournensis isolated from agro-industrial sugarcane, and the products and byproducts of this agro-industrial sugarcane were used as carbon sources for their recovery. The effect of pH, temperature, and carbon and nitrogen sources and their concentration in EPS production by submerged fermentation (SmF) was studied in 170 mL glass containers of uniform geometry at 30 °C with an initial pH of 6...
February 29, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#18
REVIEW
Jeanne M Fair, Nisreen Al-Hmoud, Mu'men Alrwashdeh, Andrew W Bartlow, Sopio Balkhamishvili, Ivane Daraselia, Annie Elshoff, Lara Fakhouri, Zura Javakhishvili, Fares Khoury, Denys Muzyka, Levan Ninua, Jean Tsao, Lela Urushadze, Jennifer Owen
As the climate changes, global systems have become increasingly unstable and unpredictable. This is particularly true for many disease systems, including subtypes of highly pathogenic avian influenzas (HPAIs) that are circulating the world. Ecological patterns once thought stable are changing, bringing new populations and organisms into contact with one another. Wild birds continue to be hosts and reservoirs for numerous zoonotic pathogens, and strains of HPAI and other pathogens have been introduced into new regions via migrating birds and transboundary trade of wild birds...
2024: Frontiers in Microbiology
#19
JOURNAL ARTICLE
Katya Kaplow, Jessica M Ruck, Macey L Levan, Alvin G Thomas, Darren Stewart, Allan B Massie, Hannah C Sung, Sarah F Pisano, Carolyn Sidoti, Dorry L Segev, Joseph Sinacore, Amy D Waterman
RATIONALE & OBJECTIVE: Understanding national attitudes about living kidney donation will enable us to identify and address existing disincentives to living kidney donation. We performed a national survey to describe living kidney donation perceptions, perceived factors that affect the willingness to donate, and analyzed differences by demographic subgroups. STUDY DESIGN: The survey items captured living kidney donation awareness, living kidney donation knowledge, willingness to donate, and barriers and facilitators to living kidney donation...
March 2024: Kidney medicine
#20
JOURNAL ARTICLE
Karen B Vanterpool, Kadiatou Diallo, Ellie Kim, Sarah E Van Pilsum Rasmussen, Morgan A Johnson, Zachary Predmore, Janetta Brundage, Brittany Barnaba, Niraj Desai, Macey L Levan, Hannah C Sung, Olivia Kates, Jeremy Sugarman, Christine M Durand
BACKGROUND: Organ transplantation from donors with hepatitis C viremia (HCV) to recipients without HCV (HCV D+/R-) has excellent medical outcomes. Less is known about the psychosocial impact and experiences of HCV D+/R- recipients, particularly outside of clinical trials. METHODS: We conducted in-depth, semistructured interviews with 24 HCV D+/R- recipients (kidney, n = 8; lung, n = 7; liver, n = 5; heart, n = 3; simultaneous heart and kidney, n = 1) who received transplants outside of clinical trials and were treated for HCV after transplant to assess their experiences and perspectives...
March 2024: Open Forum Infectious Diseases
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