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Alcoholism disease

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https://www.readbyqxmd.com/read/29232671/predicting-trajectories-of-functional-decline-in-60-to-70-year-old-people
#1
Nini H Jonkman, Vieri Del Panta, Trynke Hoekstra, Marco Colpo, Natasja M van Schoor, Stefania Bandinelli, Luca Cattelani, Jorunn L Helbostad, Beatrix Vereijken, Mirjam Pijnappels, Andrea B Maier
BACKGROUND: Early identification of people at risk of functional decline is essential for delivering targeted preventive interventions. OBJECTIVE: The aim of this study is to identify and predict trajectories of functional decline over 9 years in males and females aged 60-70 years. METHODS: We included 403 community-dwelling participants from the InCHIANTI study and 395 from the LASA study aged 60-70 years at baseline, of whom the majority reported no functional decline at baseline (median 0, interquartile range 0-1)...
December 13, 2017: Gerontology
https://www.readbyqxmd.com/read/29232562/tm6sf2-a-novel-target-for-plasma-lipid-regulation
#2
REVIEW
Ting-Ting Li, Tao-Hua Li, Juan Peng, Bei He, Lu-Shan Liu, Dang-Heng Wei, Zhi-Sheng Jiang, Xi-Long Zheng, Zhi-Han Tang
Transmembrane 6 superfamily 2 (TM6SF2), a gene identified at the locus 19p12, has been recognized to regulate plasma lipids. Here, we provide an overview of the roles of TM6SF2 as a novel target for plasma lipid regulation. We first review the association of TM6SF2 variant with plasma lipid traits, cardiovascular disease (CVD) and non-alcoholic fatty liver disease (NAFLD). Then, we present an overview about the in vivo validation of TM6SF2 as a regulator of plasma lipid levels using mice, with overexpression or knockdown/knockout of TM6SF2...
December 1, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29231919/-non-alcoholic-liver-disease-diagnosis-and-treatment
#3
REVIEW
Anna Sarosiekjeznach-Steinhagen, Joanna Ostrowska, Aneta Czerwonogrodzka-Senczyna, Iwona Boniecka
Non-alcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease in the developed world (15% to 40% of the adult population). Introduction of lifestyle changes including dietary intervention and increased physical activity is most often the first-line treatment and is intended to support not only the treatment of liver disease, but also for diseases associated with obesity, insulin resistance, diabetes and dyslipidemia. In addition to well-known metformin, there are new classes of antidiabetic drugs, including GLP-1analog, SGLT-2 antagonist, pioglitazon...
November 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29230616/elevated-inflammation-in-association-with-alcohol-abuse-among-blacks-but-not-whites-results-from-the-midus-biomarker-study
#4
Yusuf Ransome, Natalie Slopen, Oskar Karlsson, David R Williams
Some studies document racial disparities in self-reported health associated with alcohol use and abuse. However, few studies examined biomarkers that underlie the onset of alcohol-related chronic diseases. We investigated whether the association between alcohol abuse and five biomarkers of inflammation (CRP, IL-6, fibrinogen, E-selectin, sICAM-1) vary between Black and White Americans aged 35 to 84 (n = 1173) from the Midlife in the United States Biomarker Study. Multivariable Ordinary Least Squares regressions were used to assess Black-White differences in the association between alcohol abuse and the biomarkers...
December 11, 2017: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/29229391/hepatocyte-specific-clusterin-overexpression-attenuates-diet-induced-nonalcoholic-steatohepatitis
#5
Jin-Sung Park, Young-Jun Shim, Byeong-Ho Kang, Woon-Kyu Lee, Bon-Hong Min
Clusterin is a multifunctional glycoprotein that plays important roles and is up-regulated in liver diseases such as hepatitis and hepatocellular carcinoma. However, little is known about the significance of clusterin in the pathogenesis of non-alcoholic steatohepatitis (NASH). The aim of this study is to examine the role of clusterin in progression of steatohepatitis in mice fed a methionine and choline deficient (MCD) diet. We generated hepatocyte-specific clusterin overexpression (hCLU-tg) mice, and hCLU-tg mice showed lower levels of hepatic triglycerides, less infiltration of macrophages and reduction of TNF-α, activation of Nrf-2 than wild-type littermates fed the MCD diet...
December 8, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29228928/association-between-high-density-lipoprotein-cholesterol-level-and-pulmonary-function-in-healthy-korean-adolescents-the-js-high-school-study
#6
Ji Hye Park, Seyeon Mun, Dong Phil Choi, Joo Young Lee, Hyeon Chang Kim
BACKGROUND: Accumulating evidence suggests that high-density lipoprotein (HDL) cholesterol is associated with pulmonary function and pulmonary disorders. The aim of this study was to evaluate the association between HDL cholesterol and pulmonary function in healthy adolescents. METHODS: This cross-sectional study was based on data collected for the JS High School study. The analysis included 644 adolescents (318 male and 326 female) aged 15-16 years old and free from asthma or chronic obstructive pulmonary disease...
December 11, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29228666/granulocyte-colony-stimulating-factor-treatment-in-non-alcoholic-fatty-liver-disease-beyond-marrow-cell-mobilization
#7
Ho Hyun Nam, Dae Won Jun, Kiseok Jang, Waqar Khalid Saeed, Jai Sun Lee, Hyeon Tae Kang, Yeon Ji Chae
Protective effects of granulocyte colony stimulating factor (G-CSF) in acute liver injury via marrow cell mobilization have been reported in several studies. But exact mode of action and optimal protocol of G-CSF has been still doubt in chronic disease. Here we investigated mode of action and optimization of G-CSF as a treatment for non-alcoholic fatty liver disease (NAFLD). Various doses of conventional G-CSF (30 μg/kg once weekly, once daily for 5 days, twice weekly) and long acting G-CSF (30 μg/kg once a month) were evaluated in two kinds of NAFLD animal models to optimize the G-CSF protocol...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228416/dental-health-in-patients-affected-by-alcohol-use-disorders-a-cross-sectional-study
#8
P F Manicone, C Tarli, A Mirijello, L Raffaelli, G A Vassallo, M Antonelli, M M Rando, C Mosoni, A Cossari, L Lavorgna, F Caputo, A D'Addona, A Gasbarrini, G Addolorato
OBJECTIVE: Chronic alcohol abuse represents a risk factor for oral diseases, in particular, oral cancer. Periodontal disease has been showed to be involved in the pathophysiology of cardiovascular and metabolic diseases, such as atherosclerosis and liver steatosis. The role of chronic alcohol consumption on periodontitis is still controversial. The aim of the study was to evaluate the effect of chronic alcohol abuse on oral health. PATIENTS AND METHODS: Twenty-three alcohol use disorders (AUD) patients and twenty-three healthy social drinkers underwent an oral examination by trained oral clinicians in order to evaluate oral and dental health...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29228164/liver-fat-content-non-alcoholic-fatty-liver-disease-and-ischaemic-heart-disease-mendelian-randomization-and-meta-analysis-of-279%C3%A2-013-individuals
#9
Bo Kobberø Lauridsen, Stefan Stender, Thomas Skårup Kristensen, Klaus Fuglsang Kofoed, Lars Køber, Børge G Nordestgaard, Anne Tybjærg-Hansen
Aims: In observational studies, non-alcoholic fatty liver disease (NAFLD) is associated with high risk of ischaemic heart disease (IHD). We tested the hypothesis that a high liver fat content or a diagnosis of NAFLD is a causal risk factor for IHD. Methods and results: In a cohort study of the Danish general population (n = 94 708/IHD = 10 897), we first tested whether a high liver fat content or a diagnosis of NAFLD was associated observationally with IHD...
December 8, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29227870/impact-of-alcohol-drinking-on-acetylcholine-induced-coronary-artery-spasm-in-korean-populations
#10
Sung Min Sohn, Byoung Geol Choi, Se Yeon Choi, Jae Kyeong Byun, Ahmed Mashaly, Yoonjee Park, Won Young Jang, Woohyeun Kim, Jah Yeon Choi, Eun Jin Park, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh, Seung-Woon Rha
BACKGROUND AND AIMS: Generally, immoderate alcohol consumption is associated with variant angina and accepted as one of the risk factors for coronary artery spasm (CAS), but evidence is lacking in this regard. The aim of this study is to evaluate the impact of alcohol consumption and drinking pattern on CAS by acetylcholine (ACH) provocation test and long-term clinical outcomes. METHODS: A total of 5491 patients with typical or atypical chest pain, without significant coronary artery disease, who underwent intracoronary ACH provocation test, were enrolled prospectively, and retrospectively analyzed in this study...
December 8, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29227330/total-bile-acid-levels-are-associated-with-left-atrial-volume-and-cardiac-output-in-patients-with-cirrhosis
#11
Andrei M Voiosu, Signe Wiese, Theodor A Voiosu, Jens Hove, Flemming Bendtsen, Søren Møller
BACKGROUND AND AIMS: Bile acids (BAs) are potent signaling molecules involved in the regulation of several metabolic and functional aspects of cardiovascular homeostasis. BA pool alteration in cirrhosis may contribute toward the development of hemodynamic and cardiac disturbances. We aimed to investigate the association between total BA levels and echocardiographic and biochemical markers of cardiac dysfunction in cirrhotic patients. METHODS: Cirrhotic patients were enrolled prospectively in this hypothesis-generating study and evaluated for cardiac and hemodynamic dysfunction through clinical, echocardiographic, and biochemical means...
December 8, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29226798/long-term-effects-of-a-swedish-lifestyle-intervention-programme-on-lifestyle-habits-and-quality-of-life-in-people-with-increased-cardiovascular-risk
#12
Matthias Lidin, Elin Ekblom-Bak, Monica Rydell Karlsson, Mai-Lis Hellénius
AIMS: The aim of this study was to evaluate the effects of a structured intervention programme on lifestyle habits and quality of life after six months and one year in participants with increased cardiovascular risk. METHODS: Participants aged ≥18 years with increased cardiovascular risk were referred from primary health care and hospitals. The programme was launched at an outpatient clinic in a department of cardiology at a university hospital. It consisted of individual visits to a nurse for a health check-up and lifestyle counselling at baseline, after six months and at one year...
December 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/29226321/the-severity-of-periodontitis-and-metabolic-syndrome-in-korean-population-the-dong-gu-study
#13
O S Kim, M H Shin, S S Kweon, Y H Lee, O J Kim, Y J Kim, H J Chung
OBJECTIVES: We assessed the association between periodontal disease status and metabolic syndrome (MetS) and its individual components in Korean adults over 50 years old. MATERIAL AND METHODS: In the Dong-gu study, 5078 men and women aged over 50 years were included. They underwent a questionnaire survey, physical assessment, biochemical assessment and periodontal assessment. The percentages of sites with periodontal probing depth ≥4 mm, and clinical attachment loss ≥4 mm were recorded for each participant...
December 10, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29226116/alcohol-consumption-in-diabetic-patients-with-nonalcoholic-fatty-liver-disease
#14
Preya J Patel, David Smith, Jason P Connor, Leigh U Horsfall, Kelly L Hayward, Fabrina Hossain, Suzanne Williams, Tracey Johnson, Katherine A Stuart, Nigel N Brown, Nivene Saad, Andrew D Clouston, Katharine M Irvine, Anthony W Russell, Patricia C Valery, Elizabeth E Powell
Aim: To examine the association between lifetime alcohol consumption and significant liver disease in type 2 diabetic patients with NAFLD. Methods: A cross-sectional study assessing 151 patients with NAFLD at risk of clinically significant liver disease. NAFLD fibrosis severity was classified by transient elastography; liver stiffness measurements ≥8.2 kPa defined significant fibrosis. Lifetime drinking history classified patients into nondrinkers, light drinkers (always ≤20 g/day), and moderate drinkers (any period with intake >20 g/day)...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29226108/severe-alcoholic-hepatitis-atypical-presentation-with-markedly-elevated-alkaline-phosphatase
#15
Page Axley, Kirk Russ, Ashwani K Singal
Alcoholic hepatitis (AH) is an acute inflammatory liver disease with poor prognosis. Infections in AH are difficult to detect and contribute to short-term mortality. Intrahepatic cholestasis and elevated alkaline phosphatase levels are also associated with worse outcomes. This report describes an uncommon presentation of severe AH.
December 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/29226105/non-alcoholic-fatty-liver-disease-a-clinical-update
#16
REVIEW
Joseph M Pappachan, Shithu Babu, Babu Krishnan, Nishal C Ravindran
Non-alcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease in developed countries because of the obesity epidemic. The disease increases liver-related morbidity and mortality, and often increases the risk for other comorbidities, such as type 2 diabetes and cardiovascular disease. Insulin resistance related to metabolic syndrome is the main pathogenic trigger that, in association with adverse genetic, humoral, hormonal and lifestyle factors, precipitates development of NAFLD...
December 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/29225776/the-sedentary-r-evolution-have-we-lost-our-metabolic-flexibility
#17
Jens Freese, Rainer Johannes Klement, Begoña Ruiz-Núñez, Sebastian Schwarz, Helmut Lötzerich
During the course of evolution, up until the agricultural revolution, environmental fluctuations forced the human species to develop a flexible metabolism in order to adapt its energy needs to various climate, seasonal and vegetation conditions. Metabolic flexibility safeguarded human survival independent of food availability. In modern times, humans switched their primal lifestyle towards a constant availability of energy-dense, yet often nutrient-deficient, foods, persistent psycho-emotional stressors and a lack of exercise...
2017: F1000Research
https://www.readbyqxmd.com/read/29224673/understanding-the-role-of-environmental-factors-in-the-development-of-systemic-lupus-erythematosus
#18
REVIEW
Christine G Parks, Aline de Souza Espindola Santos, Medha Barbhaiya, Karen H Costenbader
Systemic lupus erythematosus (SLE) is a multisystem disease with a complex etiology. Its risk is higher among women, racial and ethnic minorities, and individuals with a family history of SLE or related autoimmune diseases. It is believed that genetic factors interact with environmental exposures throughout the lifespan to influence susceptibility to developing SLE. The strongest epidemiologic evidence exists for increased risk of SLE associated with exposure to crystalline silica, current cigarette smoking, use of oral contraceptives, and postmenopausal hormone replacement therapy, while there is an inverse association with alcohol use...
June 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29223918/postmortem-computed-tomography-findings-in-cases-of-bath-related-death-applicability-and-limitation-in-forensic-practice
#19
Satoko Mishima, Hideto Suzuki, Tatsushige Fukunaga, Yoko Nishitani
PURPOSE: Bath-related deaths occur frequently in Japan, and many of these deaths are diagnosed as death from disease without autopsy in the current Japanese death-investigation system. Therefore, we aimed to examine the postmortem computed tomography (PMCT) findings of bath-related deaths to determine if PMCT can differentiate between real cases of drowning and sudden deaths not related to drowning. METHODS: Bath-related deaths were sampled from all autopsies conducted at the Tokyo Medical Examiner's Office from September 2015 to August 2016...
December 2, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29223583/the-global-burden-of-tuberculosis-results-from-the-global-burden-of-disease-study-2015
#20
(no author information available yet)
BACKGROUND: An understanding of the trends in tuberculosis incidence, prevalence, and mortality is crucial to tracking of the success of tuberculosis control programmes and identification of remaining challenges. We assessed trends in the fatal and non-fatal burden of tuberculosis over the past 25 years for 195 countries and territories. METHODS: We analysed 10 691 site-years of vital registration data, 768 site-years of verbal autopsy data, and 361 site-years of mortality surveillance data using the Cause of Death Ensemble model to estimate tuberculosis mortality rates...
December 6, 2017: Lancet Infectious Diseases
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