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https://www.readbyqxmd.com/read/28732370/silibinin-an-old-drug-for-hematological-disorders
#1
REVIEW
Hai Zou, Xing-Xing Zhu, Guo-Bing Zhang, Yuan Ma, Yi Wu, Dong-Sheng Huang
Silibinin (silybin), a non-toxic natural polyphenolic flavonoid, is the principal and the most biologically active component of silymarin. It is efficient in the treatment of acute and chronic liver disorders caused by toxins, drug, alcohol, hepatitis, and gall bladder disorders. Further, in our previous studies, we explored the anti-cancer efficacy in common cancers, such as lung, prostatic, colon, breast, bladder, as well as, hepatocellular carcinoma. Interestingly, silibinin is still not solely limited to the treatment of these diseases...
July 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28731995/-update-on-chronic-pancreatitis-review-article
#2
Frank Czul, Emmanuel Coronel, Jean A Donet
Chronic pancreatitis is a progressive fibro-inflammatory disease of the pancreas characterized by irreversible fibrosis of the gland with eventual failure of exocrine and endocrine functions and hallmark features of abdominal pain, malabsorption, malnutrition, diabetes mellitus and pancreatic calcifications. In many patients this disease results from a complex mix of environmental (eg, alcohol, cigarettes, and occupational chemicals), genetic factors and a few patients with hereditary or autoimmune disease...
April 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/28730729/traffic-related-air-pollution-associations-with-cytokeratin-18-a-marker-of-hepatocellular-apoptosis-in-an-overweight-and-obese-paediatric-population
#3
S Hsieh, B P Leaderer, A E Feldstein, N Santoro, L A McKay, S Caprio, R McConnell
INTRODUCTION: Traffic-related air pollution causes fatty liver, inflammation and fibrosis in animal models, but there have been few studies in humans. OBJECTIVES: To test the hypothesis that traffic-related air pollution causes non-alcoholic fatty liver disease (NAFLD) and increased markers for non-alcoholic steatohepatitis (NASH); and that NAFLD increases liver susceptibility to increased NASH risk. METHODS: Data collected prospectively from 74 overweight or obese children were obtained from the Yale Pediatric Obesity Clinic...
July 20, 2017: Pediatric Obesity
https://www.readbyqxmd.com/read/28730512/nlrp3-deletion-inhibits-the-non-alcoholic-steatohepatitis-development-and-inflammation-in-kupffer-cells-induced-by-palmitic-acid
#4
Can Cai, Xiwen Zhu, Peizhi Li, Jinzheng Li, Jianping Gong, Wei Shen, Kun He
The cleavage and secretion of pro-inflammatory cytokines IL-1β and IL-18 is regulated by NLRP3 (NACHT, LRR, and PYD domain-containing protein 3) inflammasome activation. Kupffer cells (KCs) are implicated in the pathogenesis of various liver diseases, such as non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease, and liver fibrosis. However, the role of NLRP3 played in the non-alcoholic steatohepatitis (NASH) has yet to be evaluated. In the present study, methionine-choline-deficient (MCD) diet was used to establish the mice NASH model...
July 20, 2017: Inflammation
https://www.readbyqxmd.com/read/28730160/epigenetic-interactions-between-alcohol-and-cannabinergic-effects-focus-on-histone-modification-and-dna-methylation
#5
Tiyash Parira, Alejandra Laverde, Marisela Agudelo
Epigenetic studies have led to a more profound understanding of the mechanisms involved in chronic conditions. In the case of alcohol addiction, according to the National Institute on Alcohol Abuse and Alcoholism, 16 million adults suffer from Alcohol Use Disorders (AUDs). Even though therapeutic interventions like behavioral therapy and medications to prevent relapse are currently available, no robust cure exists, which stems from the lack of understanding the mechanisms of action of alcohol and the lack of development of precision medicine approaches to treat AUDs...
April 2017: Journal of Alcoholism and Drug Dependence
https://www.readbyqxmd.com/read/28729139/endoscope-drying-and-its-pitfalls
#6
REVIEW
J Kovaleva
Inadequate drying of endoscope channels is a possible cause of replication and survival of remaining pathogens during storage. The presence during storage of potentially contaminated water in endoscope channels may promote bacterial proliferation and biofilm formation. An incomplete drying procedure or lack of drying and not storing in a vertical position are the most common problems identified during drying and endoscope storage. Inadequate drying and storage procedures, together with inadequate cleaning and disinfection, are the most important sources of endoscope contamination and post-endoscopic infection...
July 17, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28729040/-long-term-effects-of-intensive-intervention-on-changes-in-lifestyle-in-patients-with-hyperfibrinogenaemia-and-moderate-high-cardiovascular-risk
#7
Laura Illamola Martin, Juan José Rodríguez Cristobal, Carlos Alonso-Villaverde, Betlem Salvador-González, Irene Moral Pelaez
OBJECTIVES: To determine whether the benefit on cardiovascular risk factors (CVRF) persists 5 years after an intensive intervention in lifestyle (LS) that lasted 2 years, in patients with hyperfibrinogenaemia and moderate or high cardiovascular risk. DESIGN: multicentre prospective observational study. LOCATION: 13 Primary Care Centres in Barcelona and Baix Llobregat. PARTICIPANTS: A total of 300 patients who completed the EFAP study (146 intervention group, 154 control group)...
July 17, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28728905/perceptions-of-clostridium-difficile-infections-among-infection-control-professionals-in-taiwan
#8
Yuan-Pin Hung, Jen-Chieh Lee, Hsiao-Ju Lin, Chun-Wei Chiu, Jia-Ling Wu, Hsiao-Chieh Liu, I-Hsiu Huang, Pei-Jane Tsai, Wen-Chien Ko
BACKGROUND: High Clostridium difficile colonization and infection rates among hospitalized patients had been noted in Taiwan. Nevertheless, the cognition about clinical diagnosis and management of CDI among infection control professionals in Taiwan is not clear. MATERIAL AND METHODS: A 24-item survey questionnaire about the diagnosis, therapy, or infection control policies toward CDI was distributed in the annual meeting of the Infectious Disease Society of Taiwan (IDST) in October 2015 and Infectious Control Society of Taiwan (ICST) in April 2016...
June 29, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28728780/detecting-regional-stiffness-changes-in-aortic-aneurysmal-geometries-using-pressure-normalized-strain
#9
Doran S Mix, Ling Yang, Camille C Johnson, Nathan Couper, Ben Zarras, Isaac Arabadjis, Lauren E Trakimas, Michael C Stoner, Steven W Day, Michael S Richards
Transabdominal ultrasound elasticity imaging could improve the assessment of rupture risk for abdominal aortic aneurysms by providing information on the mechanical properties and stress or strain states of vessel walls. We implemented a non-rigid image registration method to visualize the pressure-normalized strain within vascular tissues and adapted it to measure total strain over an entire cardiac cycle. We validated the algorithm's performance with both simulated ultrasound images with known principal strains and anatomically accurate heterogeneous polyvinyl alcohol cryogel vessel phantoms...
July 17, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28728746/linking-sex-differences-in-non-alcoholic-fatty-liver-disease-to-bile-acid-signaling-gut-microbiota-and-high-fat-diet
#10
John Y L Chiang
This commentary highlights the article by Jena et al that studied the complex interplay between diet, bile acids, sex, and dysbiosis in hepatic steatosis and inflammation.
August 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28727853/independent-and-joint-effects-of-moderate-alcohol-consumption-and-smoking-on-the-risks-of-non-alcoholic-fatty-liver-disease-in-elderly-chinese-men
#11
Peiyi Liu, Yanyan Xu, Yuhan Tang, Min Du, Xiao Yu, Jian Sun, Lin Xiao, Meian He, Sheng Wei, Jing Yuan, Youjie Wang, Yuan Liang, Tangchun Wu, Xiaoping Miao, Ping Yao
BACKGROUND: Whether cigarette smoking and moderate drinking are associated with non-alcoholic fatty liver disease (NAFLD)has not been fully described. This study investigated the separate and joint effects of smoking and moderate drinking on Chinese men with NAFLD. METHODS: Across-sectional assay from DFTJ Cohort study was performed with a size of 9432 elderly Chinese men excluding excessive alcohol consumption (<210g/week). Fatty liver was diagnosed by standardized ultrasonographic inspection...
2017: PloS One
https://www.readbyqxmd.com/read/28727631/one-year-of-baclofen-in-100-patients-with-or-without-cirrhosis-a-french-real-life-experience
#12
Camille Barrault, Hortensia Lison, Françoise Roudot-Thoraval, Armand Garioud, Charlotte Costentin, Véronique Béhar, Mourad Medmoun, Georges Pulwermacher, Hervé Hagège, Jean-François Cadranel
BACKGROUND: Several studies have suggested the efficacy of baclofen in reducing alcohol consumption, leading to a temporary recommendation for use in France. AIM: Our aim was to report our experience in using baclofen in alcohol-dependant patients with or without liver cirrhosis. PATIENTS AND METHODS: Consecutive patients from two liver and alcohol units were recruited over a 3-year period and received increasing doses of baclofen associated with social, psychological, and medical care...
July 19, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28727541/ic04750post-discharge-smoking-cessation-in-subgroups-of-hospitalized-smokers-a-latent-class-analysis
#13
Thomas Ylioja, Gerald Cochran, Yuchiao Chang, Hilary A Tindle, Nancy A Rigotti
CLEAN VERSION ABSTRACT Background: Hospitalization presents a window of opportunity to treat smoking, and hospital-initiated smoking treatment has demonstrated effectiveness. Despite effective interventions, not all smokers will discontinue use, highlighting the need to better understand which patients achieve cessation. Traditional regression methods may not capture the complexity of inpatient smoker subgroups. METHODS: We conducted latent class analysis (LCA) with data from 397 hospitalized adult cigarette smokers enrolled in a randomized trial...
July 20, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28727520/undocumented-immigration-drug-problems-and-driving-under-the-influence-in-the-united-states-1990-2014
#14
Michael T Light, Ty Miller, Brian C Kelly
OBJECTIVES: To examine the influence of undocumented immigration in the United States on 4 different metrics of drug and alcohol problems: drug arrests, drug overdose fatalities, driving under the influence (DUI) arrests, and DUI deaths. METHODS: We combined newly developed state-level estimates of the undocumented population between 1990 and 2014 from the Center for Migration Studies with arrest data from the Federal Bureau of Investigation Uniform Crime Reports and fatality information from the Fatality Analysis Reporting System and the Centers for Disease Control and Prevention Underlying Cause of Death database...
July 20, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28726934/clove-extract-functions-as-a-natural-fatty-acid-synthesis-inhibitor-and-prevents-obesity-in-a-mouse-model
#15
Yiran Ding, Zhennan Gu, Yihe Wang, Shunhe Wang, Haiqin Chen, Hao Zhang, Wei Chen, Yong Q Chen
Numerous medicinal plants have been reported to prevent various chronic diseases. In this study, we screened a new FASN inhibitor-alcohol extract of clove (AEC) using a fast microplate method developed in our laboratory. The major components of AEC were: eugenol (42.27%), acetyl eugenol (29.12%), caryophyllene (15.40%), and humulene (3.22%). Fatty acid synthase (FASN) is a key enzyme for de novo lipogenesis, and it has been suggested as a potential therapeutic target in cancer and obesity. We have tested the ability of AEC to inhibit FASN in mammalian cells and tissues...
July 20, 2017: Food & Function
https://www.readbyqxmd.com/read/28726651/factors-associated-with-post-stroke-fatigue-within-the-first-3-month-after-stroke
#16
I Delva, N Lytvynenko, M Delva
Aim - identify socio-demographic, personal and psychological factors associated with certain post-stroke fatigue (PSF) domains within first 3 months after stroke. There were examined patients consequently in definite time points after ischemic or hemorrhagic strokes: at hospital stay (234 patients), in 1 month (203 patients) and in 3 months (176 patients). Global PSF and certain PSF domains were measured by multidimensional fatigue inventory-20 (MFI-20) scale. In multivariate logistic regression analysis the majority of variables (gender, marital status, education level, smoking status, level of alcohol consumption, apathetic impairments, arterial hypertension, atrial fibrillation, ischemic heart disease, diabetes mellitus, body mass index, waist circumference) were not significantly associated with any PSF domain risk at any time point after stroke...
June 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28726335/preperitoneal-fat-as-a-noninvsasive-marker-of-increased-risk-of-severe-non-alcoholic-fatty-liver-disease-in-patients-with-type-2-diabetes
#17
Daniella Braz Parente, Jaime Araújo Oliveira Netso, Pedro Emmanuel Alvarenga Americano Brasil, Fernando Fernandes Paiva, José Pedro Rodrigues Ravani, Marilia Brito Gomes, Valeria Lanzoni, Carlos Frederico Ferreira Campos, Lilian Machado-Silva, Renata Mello Perez, Rosana Souza Rodrigues
BACKGROUND AND AIM: Fat distribution may have prognostic value in the evaluation of non-alcoholic fatty liver disease. This study was conducted to evaluate associations of MRI-measured abdominal fat areas with steatosis, steatohepatitis, and fibrosis, assessed histopathologically, in patients with type 2 diabetes. METHODS: This prospective study included 66 patients with type 2 diabetes (12 males, 54 females, age 26-68 years), without chronic liver disease of other causes...
July 20, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28725982/analysis-of-risk-factors-influencing-the-outcome-of-the-epley-maneuver
#18
E Domínguez-Durán, E Domènech-Vadillo, M G Álvarez-Morujo de Sande, R González-Aguado, G Guerra-Jiménez, Á Ramos-Macías, C Morales-Angulo, A J Martín-Mateos, E Figuerola-Massana, H Galera-Ruiz
Benign paroxysmal positional vertigo (BPPV) is the most frequent type of vertigo. The treatment of canalithiasis of the posterior semicircular canal consists in performing a particle-repositioning maneuver, such as the Epley maneuver (EM). However, the EM is not effective in all cases. The objective of this study is to identify risk factors, which predict the EM failure, among the clinical variables recorded in anamnesis and patient examination. This is an observational prospective multicentric study. All patients presenting with BPPV were recruited and applied the EM and appointed for a follow-up visit 7 days later...
July 19, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28725625/evaluation-of-effect-of-alcoholic-extract-of-heartwood-of-pterocarpus-marsupium-on-in%C3%A2-vitro-antioxidant-anti-glycation-sorbitol-accumulation-and-inhibition-of-aldose-reductase-activity
#19
Pankaj Gupta, Vivek Jain, Ashutosh Pareek, Preeti Kumari, Randhir Singh, Priyanka Agarwal, Veena Sharma
Rising popularity of phytomedicines in various diseased conditions have strengthened the significance of plant-research and evaluation of phytoextracts in clinical manifestations. Pterocarpus marsupium Roxb., a medicinal plant, known for its anti-oxidant and anti-diabetic activity is a rich source of phytochemicals with antihyperglycemic and antihyperlipidemic activities. However, its possible role in diabetic complications is not evaluated yet. The present study explores the possible role of alcoholic extract of heartwood of P...
July 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28725301/review-of-infectious-etiology-of-acute-pancreatitis
#20
REVIEW
Prashanth Rawla, Sathyajit S Bandaru, Anantha R Vellipuram
While gallstones and alcoholism are widely known to be the most common causative agents of acute pancreatitis, about 10% of cases are thought to be caused by infectious microorganisms. These microorganisms include viruses (e.g. mumps, Coxsackie B, and hepatitis), bacteria (e.g. Mycoplasma pneumoniae and leptospirosis), and parasites (e.g. Ascaris lumbricoides, Fasciola hepatica, and hydatid disease). Each organism causes acute pancreatitis through diverse mechanisms. The review is primarily conducted in an attempt to provide a better understanding of the possibility of acute pancreatitis presenting as a complication relating to these organisms, and the aim is to guide future diagnoses, management, and predictions of complications...
June 2017: Gastroenterology Research
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