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https://www.readbyqxmd.com/read/29929022/risk-factors-for-surgical-site-infection-following-operative-treatment-of-ankle-fractures-a-systematic-review-and-meta-analysis
#1
REVIEW
Jiashen Shao, Huixin Zhang, Bing Yin, Jia Li, Yanbin Zhu, Yingze Zhang
BACKGROUND: This study aims to quantitatively summarize risk factors associated with surgical site infection after open reduction and internal fixation of ankle fractures. METHODS: Relevant original studies were searched in Medline, Embase, China National Knowledge Infrastructure, Wanfang database and Cochrane central database (all through April 2018). Studies eligible had to meet the quality assessment criteria by Newcastle-Ottawa Scale and to evaluate the risk factors for surgical site infection after open reduction and internal fixation of ankle fractures...
June 18, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29928260/liver-enlargement-predicts-obstructive-sleep-apnea-hypopnea-syndrome-in-morbidly-obese-women
#2
Giovanna Scartabelli, Giorgia Querci, Letizia Marconi, Giovanni Ceccarini, Paolo Piaggi, Paola Fierabracci, Guido Salvetti, Giovanni Cizza, Salvatore Mazzeo, Jacopo Vitti, Slava Berger, Antonio Palla, Ferruccio Santini
Obstructive sleep apnea-hypopnea syndrome (OSAHS) is frequently present in patients with severe obesity, but its prevalence especially in women is not well defined. OSAHS and non-alcoholic fatty liver disease are common conditions, frequently associated in patients with central obesity and metabolic syndrome and are both the result of the accumulation of ectopic fat mass. Identifying predictors of risk of OSAHS may be useful to select the subjects requiring instrumental sleep evaluation. In this cross-sectional study, we have investigated the potential role of hepatic left lobe volume (HLLV) in predicting the presence of OSAHS...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29928186/hypothermia-related-acute-pancreatitis
#3
Kyawzaw Lin, Emmanuel Ofori, Aung Naing Lin, Sithu Lin, Thinzar Lin, Ameer Rasheed, Viswanath Vasudevan, Madhavi Reddy
Acute pancreatitis (AP) is an inflammatory disease presenting from mild localized inflammation to severe infected necrotic pancreatic tissue. In the literature, there are a few cases of hypothermia-induced AP. However, the association between hypothermia and AP is still a myth. Generally, mortality from acute pancreatitis is nearly 3-6%. Here, we present a 40-year-old chronic alcoholic female who presented with acute pancreatitis induced by transient hypothermia. A 40-year-old chronic alcoholic female was hypothermic at 81°F on arrival which was improved to 91...
May 2018: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29928152/novel-human-genome-variants-associated-with-alcohol-use-disorders-identified-in-a-lithuanian-cohort
#4
Karolis Baronas, Tautvydas Rančelis, Aidas Pranculis, Ingrida Domarkienė, Laima Ambrozaitytė, Vaidutis Kučinskas
Background: Alcohol use disorder (AUD) is a chronic relapsing brain disease characterized by compulsive alcohol use, loss of control over alcohol intake, and a negative emotional state when not using (1). Abusive alcohol consumption directly affects a person's physical and psychological health and social life. The World Health Organization has shown that Lithuania is a leading country in pure alcohol consumption in the world (2). The aim of this study is to find novel genome variants that are associated with the AUD in the Lithuanian cohort...
2018: Acta Medica Lituanica
https://www.readbyqxmd.com/read/29928018/polymorphisms-in-the-receptor-for-advanced-glycation-end-products-rage-gene-and-circulating-rage-levels-as-a-susceptibility-factor-for-non-alcoholic-steatohepatitis-nash
#5
Rohini Mehta, Gladys Shaw, Peter Masschelin, Sean Felix, Munkzhul Otgonsuren, Ancha Baranova, Zachary Goodman, Zobair Younossi
Non-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome and major cause of chronic liver disease in developed countries. Its prevalence is increasing in parallel with the prevalence of obesity and other components of the metabolic syndrome. As the liver is central to the clearance and catabolism of circulating advanced glycosylation end-products (AGEs), AGEs and their cognate receptors-RAGE (receptor for AGEs) system might be involved in NAFLD in obese patients. To examine this, we investigated four common polymorphisms of RAGE gene: 1704G/T (rs184003), G82S (rs2070600), -374T/A (rs1800624) and -429T/C (rs1800625) in 340 obese patients with metabolic syndrome...
2018: PloS One
https://www.readbyqxmd.com/read/29925707/periodontitis-modifies-the-association-between-smoking-and-chronic-obstructive-pulmonary-disease-in-japanese-men
#6
Jane Harland, Michiko Furuta, Kenji Takeuchi, Shunichi Tanaka, Yoshihisa Yamashita
Periodontitis was reported to be associated with chronic obstructive pulmonary disease (COPD), and both diseases are related to smoking. To identify associations between periodontitis, smoking, and COPD, this cross-sectional study enrolled 1474 Japanese men (mean age 55.2 ± 8.9 years) surveyed between 2003 and 2006. Periodontal status was evaluated by using the community periodontal index. Periodontitis was defined as the presence of at least one sextant with a pocket depth ≥4 mm. Lung function was measured by spirometry, and COPD was defined as ratio of forced expiratory volume after 1 second to forced vital capacity of <0...
2018: Journal of Oral Science
https://www.readbyqxmd.com/read/29925476/autoimmune-diseases-are-associated-with-an-increased-risk-of-schizophrenia-a-nationwide-population-based-cohort-study
#7
Ling-Yi Wang, Shih-Fen Chen, Jen-Huai Chiang, Chung-Y Hsu, Yu-Chih Shen
OBJECTIVES: Studies have suggested a possible autoimmune contribution in a subset of patients with schizophrenia. The purpose of this study was to determine if a history of autoimmune diseases (AD) is associated with an increased risk of later onset of schizophrenia. METHODS: Taiwan's National Health Insurance Research Database was used to identify a total of 64,817 AD patients and an equal number of age-matched control patients. The incidence rates of schizophrenia with a maximum follow-up period of 10 years between patients with and without AD were compared using a Cox proportional hazard model to estimate the hazard ratio (HR) and 95% confidence interval (95% CI)...
June 17, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29925420/hepatic-steatosis-risk-is-partly-driven-by-increased-de-novo-lipogenesis-following-carbohydrate-consumption
#8
Francis W B Sanders, Animesh Acharjee, Celia Walker, Luke Marney, Lee D Roberts, Fumiaki Imamura, Benjamin Jenkins, Jack Case, Sumantra Ray, Samuel Virtue, Antonio Vidal-Puig, Diana Kuh, Rebecca Hardy, Michael Allison, Nita Forouhi, Andrew J Murray, Nick Wareham, Michele Vacca, Albert Koulman, Julian L Griffin
BACKGROUND: Diet is a major contributor to metabolic disease risk, but there is controversy as to whether increased incidences of diseases such as non-alcoholic fatty liver disease arise from consumption of saturated fats or free sugars. Here, we investigate whether a sub-set of triacylglycerols (TAGs) were associated with hepatic steatosis and whether they arise from de novo lipogenesis (DNL) from the consumption of carbohydrates. RESULTS: We conduct direct infusion mass spectrometry of lipids in plasma to study the association between specific TAGs and hepatic steatosis assessed by ultrasound and fatty liver index in volunteers from the UK-based Fenland Study and evaluate clustering of TAGs in the National Survey of Health and Development UK cohort...
June 20, 2018: Genome Biology
https://www.readbyqxmd.com/read/29925365/changes-in-health-in-belgium-1990-2016-a-benchmarking-analysis-based-on-the-global-burden-of-disease-2016-study
#9
C Maertens de Noordhout, H Van Oyen, N Speybroeck, B Devleesschauwer
BACKGROUND: Despite increasing of the Belgian health expenditures, several indicators related to population health showed poor results. The objectives of this study were to perform an in-depth analysis of the secular trend of Belgian health status using the Global Burden of Disease (GBD) 2016 study results for Belgium, and to compare these results with other European countries. METHODS: We collected results of the Global Burden of Disease 2016 study through the GBD results and visualization tools...
June 20, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29925336/cardiovascular-disease-cvd-and-associated-risk-factors-among-older-adults-in-six-low-and-middle-income-countries-results-from-sage-wave-1
#10
Ye Ruan, Yanfei Guo, Yang Zheng, Zhezhou Huang, Shuangyuan Sun, Paul Kowal, Yan Shi, Fan Wu
BACKGROUND: Cardiovascular disease (CVD) is one of the leading causes of death worldwide. Our study aimed to investigate the prevalence of two conditions, angina and stroke, and relevant risk factors among older adults in six low- and middle- income countries(LMICs). METHODS: The data was from World Health Organization (WHO) Study on global AGEing and adult Health (SAGE) Wave 1 in China, Ghana, India, Mexico, Russian Federation and South Africa. Presence of CVD was based on self-report of angina and stroke...
June 20, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29925274/analysis-of-cardiovascular-risk-factors-associated-with-serum-testosterone-levels-according-to-the-us-2011-2012-national-health-and-nutrition-examination-survey
#11
Chunhua Deng, Zhichao Zhang, Hongjun Li, Peng Bai, Xian Cao, Adrian Sandra Dobs
OBJECTIVE: To investigate associations between cardiovascular disease risk factors, including fasting glucose, cholesterol, high density lipoprotein cholesterol (HDL-c), LDL-c, blood pressure, body mass index (BMI), C-peptide, creatinine kinase, smoking, alcohol use, physical activity, C-reactive protein as well as homocysteine levels and cardiovascular events. METHODS: Data from 1545 men aged ≥40 years, with testosterone deficiency (TD) (<300 ng/dL) and non-TD (≥300 ng/dL) which were extracted from the National Health and Nutrition Examination Survey database 2011-2012 and analyzed...
June 20, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29925177/-alcoholic-heart-disease-a-cardiovascular-disease-risk-not-to-be-ignored
#12
N F Wang
No abstract text is available yet for this article.
June 24, 2018: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29924835/association-between-dry-eye-symptoms-and-suicidal-ideation-in-a-korean-adult-population
#13
Sun-Bi Um, Hyungseon Yeom, Na Hyun Kim, Hyeon Chang Kim, Hyung Keun Lee, Il Suh
PURPOSE: This study assessed the association of dry eyes with depression and suicidal ideation in a Korean adult population. METHODS: Data from 16408 participants (6972 men and 9436 women) aged ≥ 19 years included in the fifth Korea National Health and Nutrition Examination Survey, conducted from 2010-2012, were analyzed. For dry eyes, surveys of previous diagnosis of dry eye disease (DED) by an ophthalmologist and experience of subjective dry eye symptoms were separately used...
2018: PloS One
https://www.readbyqxmd.com/read/29924825/second-harmonic-generation-microscopy-provides-accurate-automated-staging-of-liver-fibrosis-in-patients-with-non-alcoholic-fatty-liver-disease
#14
Pik Eu Chang, George Boon Bee Goh, Wei Qiang Leow, Liang Shen, Kiat Hon Lim, Chee Kiat Tan
BACKGROUND: Assessment of severity of liver fibrosis is essential in the management of non-alcoholic fatty liver disease (NAFLD). Second Harmonic Generation (SHG) microscopy is a novel optical tissue imaging system that provides automated quantification of fibrosis based on unique architectural features of collagen. This study aims to develop and validate a SHG-based index for automated staging of liver fibrosis in patients with NAFLD. METHODS: SHG microscopy was performed on archived liver biopsy specimens from 83 patients with NAFLD...
2018: PloS One
https://www.readbyqxmd.com/read/29924801/the-time-has-come-to-eliminate-the-gaps-in-the-under-recognized-burden-of-elder-mistreatment-a-community-based-cross-sectional-study-from-rural-eastern-nepal
#15
Uday Narayan Yadav, Man Kumar Tamang, Grish Paudel, Bharat Kafle, Suresh Mehta, Varalakshmi Chandra Sekaran, Jeroen R J H Gruiskens
BACKGROUND: Elder mistreatment is a well-recognized public health issue with complex underlying factors. The current study hypothesized that there is no effect of any of the following factors on any type of elder mistreatment: ethnicity, age group, education status, gender, living arrangement, concentration problems, medication for any disease, income level of caregiver, use of alcohol and tobacco products, and dependence on family or caregivers for daily activities. MATERIALS AND METHODS: We conducted a cross-sectional study of 339 elders adults aged 60 or above residing in a rural part of eastern Nepal between August and November 2016...
2018: PloS One
https://www.readbyqxmd.com/read/29924722/interaction-of-volatile-organic-compounds-and-underlying-liver-disease-a-new-paradigm-for-risk
#16
Anna L Lang, Juliane I Beier
Occupational and environmental exposures to industrial chemicals are known to cause hepatotoxicity and liver injury, in humans and in animal models. Historically, research has focused on severe acute liver injury (e.g., fulminant liver failure) or endstage diseases (e.g., cirrhosis and HCC). However, it has become recently recognized that toxicants can cause more subtle changes to the liver. For example, toxicant-associated steatohepatitis (TASH), characterized by hepatic steatosis, and inflammation, was recently recognized in an occupational cohort exposed to vinyl chloride...
June 1, 2018: Biological Chemistry
https://www.readbyqxmd.com/read/29924298/metabolic-signature-of-healthy-lifestyle-and-its-relation-with-risk-of-hepatocellular-carcinoma-in-a-large-european-cohort
#17
Nada Assi, Marc J Gunter, Duncan C Thomas, Michael Leitzmann, Magdalena Stepien, Véronique Chajès, Thierry Philip, Paolo Vineis, Christina Bamia, Marie-Christine Boutron-Ruault, Torkjel M Sandanger, Amaia Molinuevo, Hendriek Boshuizen, Anneli Sundkvist, Tilman Kühn, Ruth Travis, Kim Overvad, Elio Riboli, Augustin Scalbert, Mazda Jenab, Vivian Viallon, Pietro Ferrari
Background: Studies using metabolomic data have identified metabolites from several compound classes that are associated with disease-related lifestyle factors. Objective: In this study, we identified metabolic signatures reflecting lifestyle patterns and related them to the risk of hepatocellular carcinoma (HCC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Design: Within a nested case-control study of 147 incident HCC cases and 147 matched controls, partial least squares (PLS) analysis related 7 modified healthy lifestyle index (HLI) variables (diet, BMI, physical activity, lifetime alcohol, smoking, diabetes, and hepatitis) to 132 targeted serum-measured metabolites and a liver function score...
June 18, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29924135/exenatide-ameliorates-hepatic-steatosis-and-attenuates-fat-mass-and-fto-gene-expression-through-pi3k-signaling-pathway-in-nonalcoholic-fatty-liver-disease
#18
Shan Li, Xiaoman Wang, Jielei Zhang, Jingyi Li, Xiaogang Liu, Yuanyuan Ma, Chao Han, Lixia Zhang, Lili Zheng
Non-alcoholic fatty liver disease (NAFLD) is a common disease associated with metabolic syndrome and can lead to life-threatening complications like hepatic carcinoma and cirrhosis. Exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist antidiabetic drug, has the capacity to overcome insulin resistance and attenuate hepatic steatosis but the specific underlying mechanism is unclear. This study was designed to investigate the underlying molecular mechanisms of exenatide therapy on NAFLD. We used in vivo and in vitro techniques to investigate the protective effects of exenatide on fatty liver via fat mass and obesity associated gene (FTO) in a high-fat (HF) diet-induced NAFLD animal model and related cell culture model...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29923681/microbiome-and-bile-acid-profiles-in-duodenal-aspirates-from-cirrhotics-the-microbiome-microbial-markers-and-liver-disease-study
#19
Jonathan P Jacobs, Tien S Dong, Vatche Agopian, Venu Lagishetty, Vinay Sundaram, Mazen Noureddin, Walid Ayoub, Francisco Durazo, Jihane Benhammou, Pedram Enayati, David Elashoff, Marc T Goodman, Joseph Pisegna, Shehnaz Hussain
AIM: Cirrhosis is a leading cause of death in the world, yet there are no well-established risk stratifying tools for lethal complications including hepatocellular carcinoma (HCC). Patients with liver cirrhosis undergo routine endoscopic surveillance, providing ready access to duodenal aspirate samples which may be a source for identifying novel biomarkers. The aim of this study was to characterize the microbiome and bile acid profiles in duodenal aspirates from patients with liver cirrhosis to demonstrate feasibility of developing biomarkers for HCC risk stratification...
June 20, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29922731/cut-off-points-for-screening-at-risk-drinking-by-audit-c-korean-version-at-emergency-department
#20
Kyung Wan Lee, Yoon Hee Choi, Jae Hee Lee
Purpose: To reduce problems caused by alcohol drinking, it is necessary to identify those with 'at-risk drinking' behavior to maximize therapeutic access or intervention. To this end, we sought to determine the cut-off point for screening of at-risk drinking by the Korean version of the AUDIT-C (Alcohol Use Disorder Identification Test-Consumption). Materials and methods: We obtained data from the scientific research project of "the supervision of the Korea Center for Disease Control and Prevention (KCDCP)" in 2010...
June 2018: Turkish Journal of Emergency Medicine
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