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Neuro Endocrine Tumors

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https://www.readbyqxmd.com/read/27904107/epidermoid-cyst-in-an-intrapancreatic-accessory-spleen-case-report-and-literature-review-of-the-preoperative-imaging-findings
#1
Shin Kato, Hideki Mori, Moriya Zakimi, Koki Yamada, Kenji Chinen, Masayuki Arashiro, Susumu Shinoura, Kaoru Kikuchi, Takahiro Murakami, Fumihito Kunishima
An epidermoid cyst arising within an intrapancreatic accessory spleen (ECIAS) is rare, and also difficult to correctly diagnose before surgery. It is mostly misdiagnosed as a cystic tumor, such as a mucinous cystic neoplasm or as a solid tumor with cystic degeneration, such as a neuro endocrine tumor. We herein report a case of ECIAS and also perform a literature review of 35 reports of ECIAS. Although the preoperative diagnosis of ECIAS using conventional imaging is relatively difficult to make, careful preoperative examinations of the features on computed tomography and magnetic resonance imaging could lead to a correct preoperative diagnosis of ECIAS which might thereby reduce the number of unnecessary resections...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27873108/flushing-in-neuro-endocrinology
#2
REVIEW
Fady Hannah-Shmouni, Constantine A Stratakis, Christian A Koch
Cutaneous flushing is a common presenting complaint in endocrine disorders. The pathophysiology of flushing involves changes in cutaneous blood flow triggered by multiple intrinsic factors that are either related to physiology or disease. Flushing can be divided into episodic or persistent causes. Episodic flushing is mediated by the release of endogenous vasoactive mediators or medications, while persistent flushing results in a fixed facial erythema with telangiectasia and cyanosis due to slow-flowing deoxygenated blood in large cutaneous blood vessels...
November 21, 2016: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/27842554/men1-redefined-a-clinical-comparison-of-mutation-positive-and-mutation-negative-patients
#3
Joanne M de Laat, Rob B van der Luijt, Carolina R C Pieterman, Maria P Oostveen, Ad R Hermus, Olaf M Dekkers, Wouter W de Herder, Anouk N van der Horst-Schrivers, Madeleine L Drent, Peter H Bisschop, Bas Havekes, Menno R Vriens, Gerlof D Valk
BACKGROUND: Multiple Endocrine Neoplasia type 1 (MEN1) is diagnosed when two out of the three primary MEN1-associated endocrine tumors occur in a patient. Up to 10-30 % of those patients have no mutation in the MEN1 gene. It is unclear if the phenotype and course of the disease of mutation-negative patients is comparable with mutation-positive patients and if these patients have true MEN1. The present study aims to describe and compare the clinical course of MEN1 mutation-negative patients with two out of the three main MEN1 manifestations and mutation-positive patients during long-term follow-up...
November 15, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27601248/first-ex-vivo-validation-of-a-radioguided-surgery-technique-with-%C3%AE-radiation
#4
E Solfaroli Camillocci, M Schiariti, V Bocci, A Carollo, G Chiodi, M Colandrea, F Collamati, M Cremonesi, R Donnarumma, M E Ferrari, P Ferroli, F Ghielmetti, C M Grana, C Mancini Terracciano, M Marafini, S Morganti, M Patanè, G Pedroli, B Pollo, L Recchia, A Russomando, M Toppi, G Traini, R Faccini
PURPOSE: A radio-guided surgery technique with β(-)-emitting radio-tracers was suggested to overcome the effect of the large penetration of γ radiation. The feasibility studies in the case of brain tumors and abdominal neuro-endocrine tumors were based on simulations starting from PET images with several underlying assumptions. This paper reports, as proof-of-principle of this technique, an ex vivo test on a meningioma patient. This test allowed to validate the whole chain, from the evaluation of the SUV of the tumor, to the assumptions on the bio-distribution and the signal detection...
September 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27453669/giant-cystic-pheochromocytoma-a-silent-entity
#5
Amit Gupta, Lovenish Bains, Manish Kumar Agarwal, Renu Gupta
Pheochromocytoma is a catecholamine secreting tumor that originate from chromaffin cells. Usually, it is solid neoplasm of the adrenal medulla, however cystic pheochromocytoma is a rare neuro-endocrine tumour that is frequently asymptomatic and often diagnosed incidentally on imaging or intra-operatively. Only a few cases of cystic pheochromocytomas have been reported in the world literature. We present a case of giant cystic pheochromocytoma in a 65 years old lady who presented with a large retroperitoneal lump, which is probably the world's third largest pheochromocytoma as per the available indexed literature...
July 2016: Urology Annals
https://www.readbyqxmd.com/read/27453459/the-role-of-macrophages-in-anti-inflammatory-activity-of-antidepressant-drugs
#6
Katarzyna Nazimek, Spencer Strobel, Paweł Bryniarski, Michael Kozlowski, Iwona Filipczak-Bryniarska, Krzysztof Bryniarski
Depression is a common disease influencing patients' quality of life, whose etiology involves complex interactions of environmental, genetic and immunological factors. The latter factors include proinflammatory activation of monocytes and macrophages and increased serum levels of proinflammatory cytokines, altogether formulated as the "macrophage theory of depression". Our current review summarizes the impact of the most commonly used antidepressant drugs on the immune response with special emphasis on the role of macrophages in the clinically observed effects...
July 14, 2016: Immunobiology
https://www.readbyqxmd.com/read/27436207/third-fourth-and-sixth-cranial-nerve-palsies-in-pituitary-apoplexy
#7
Rabih Hage, Sheila R Eshraghi, Nelson M Oyesiku, Adriana G Ioachimescu, Nancy J Newman, Valérie Biousse, Beau B Bruce
BACKGROUND: Pituitary apoplexy (PA) often presents with acute headache and neuro-ophthalmic manifestations, including ocular motility dysfunction (OMD) from cranial nerve palsies (CNPs). Our goal was to describe the epidemiology and outcomes of OMD in a large, single-center series of patients with PA. METHODS: We conducted a retrospective chart review of all patients with PA seen in our pituitary center between January 1995 and December 2012. Presenting neuro-ophthalmic, endocrine, and radiologic data, as well as neuro-ophthalmology follow-up data, were collected...
October 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27262566/neuropeptide-y1-receptor-inhibits-cell-growth-through-inactivating-mitogen-activated-protein-kinase-signal-pathway-in-human-hepatocellular-carcinoma
#8
Xiufang Lv, Fengbo Zhao, Xisong Huo, Weidong Tang, Baoying Hu, Xiu Gong, Juan Yang, Qiujin Shen, Wenxin Qin
Hepatocellular carcinoma (HCC) is one of the most common cancers, and its incidence is increasing worldwide. Neuropeptide Y (NPY) broadly expressed in the central and peripheral nervous system. It participates in multiple physiological and pathological processes through specific receptors. Evidences are accumulating that NPY is involved in development and progression in neuro- or endocrine-related cancers. However, little is known about the potential roles and underlying mechanisms of NPY receptors in HCC. In this study, we analyzed the expression of NPY receptors by real-time polymerase chain reaction, Western blot, and immunohistochemical staining...
July 2016: Medical Oncology
https://www.readbyqxmd.com/read/27180348/hearing-loss-in-patients-with-shunt-treated-hydrocephalus
#9
Margarita V Panova, Ina E Geneva, Kalina I Madjarova, Miroslava N Bosheva
Hearing loss is a common manifestation of the long-term complications in patients with shunt treated hydrocephalus along with motor development disturbance, cognitive and visual impairment, epilepsy and endocrine disorders. The aim of the present study was to investigate the alterations of hearing in patients with shunt treated hydrocephalus of non-tumor etiology and at least one year after implantation of ventriculo-peritoneal shunt, as well as their impact on the quality of life of patients. The study included 70 patients (age range 1...
July 2015: Folia Medica
https://www.readbyqxmd.com/read/27117097/-aspartate-aminotransferase-key-enzyme-in-the-human-systemic-metabolism
#10
REVIEW
Dagmara Otto-Ślusarczyk, Wojciech Graboń, Magdalena Mielczarek-Puta
Aspartate aminotransferase is an organ-nonspecific enzyme located in many tissues of the human body where it catalyzes reversible reaction of transamination. There are two aspartate aminotransferase isoforms--cytoplasmic (AST1) and mitochondrial (AST2), that usually occur together and interact with each other metabolically. Both isoforms are homodimers containing highly conservative regions responsible for catalytic properties of enzyme. The common feature of all aspartate aminotransfeses is Lys - 259 residue covalent binding with prosthetic group - pyridoxal phosphate...
2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/26994644/broncho-biliary-fistula-secondary-to-biliary-obstruction-and-lung-abscess-in-a-patient-with-pancreatic-neuro-endocrine-tumor
#11
Dipanjan Panda, Mayank Aggarwal, Vikas Yadav, Sachin Kumar, Amar Mukund, Saphalta Baghmar
We present a case report of broncho-biliary fistula that developed due to the blockage of biliary stent placed during the management of pancreatic neuroendocrine tumor (pNET); diagnosed on high clinical suspicion, percutaneous cholangiogram and contrast enhanced computed tomography (CECT); and successfully treated with percutaneous transhepatic biliary drainage (PTBD).
June 2016: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/26855717/primary-neuroendocrine-tumor-of-liver-rare-tumor-of-liver
#12
Seyed Reza Mousavi, Mahsa Ahadi
INTRODUCTION: A neuroendocrine tumor has known as a neuroendocrine system tumor. Rarely, neuroendocrines have found in other areas, like the liver, gallbladder, bile ducts, kidneys, ovaries or testicles. CASE PRESENTATION: We have a 41-year-old woman has referred to our medical center, complaining of fullness and vague pain on her right upper quadrant. The liver scan, sonography, MRI demonstrated multi lobular cysts in 6th and 7 th seg-ments of her liver and chest imaging was normal, oc-terotid scan has not shwon metastatic neuroendocrine tour of liver...
December 2015: Iranian Journal of Cancer Prevention
https://www.readbyqxmd.com/read/26412891/gamma-knife-radiosurgery-of-craniopharyngioma-results-of-30-cases-treated-at-nagoya-radiosurgery-center
#13
Tatsuya Kobayashi, Takahiko Tsugawa, Manabu Hatano, Chisa Hashizume, Yoshimasa Mori, Yuta Shibamoto
Evaluation of 30 cases of craniopharyngioma treated by Gamma Knife at Nagoya Radiosurgery Center (NRC), Nagoya Kyoritsu Hospital since July, 2004 has been made. The mean volume of the tumor was 2.64 ml, which was treated with the marginal dose of 11.7 Gy. Mean follow-up period was 79.9 months. The effects were evaluated by MRI findings, neuro-endocrine and hypothalamic signs and symptoms, complications and KPS every 3~6 months. As the results, complete remission was obtained in 8, partial remission in 12, no change in 6, progression in 3, in which two died by hypothalamic invasion...
August 2015: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/26261665/neoplastic-lesions-in-cadasil-syndrome-report-of-an-autopsied-japanese-case
#14
Wael Abdo Hassan, Naoka Udaka, Akihiko Ueda, Yukio Ando, Takaaki Ito
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) is one of the most common heritable causes of stroke and dementia in adults. The gene involved in the pathogenesis of CADASIL is Notch3; in which mutations affect the number of cysteine residues in its extracellular domain, causing its accumulation in small arteries and arterioles of the affected individuals. Besides the usual neurological and vascular findings that have been well-documented in CADASIL patients, this paper additionally reports multiple neoplastic lesions that were observed in an autopsy case of CADASIL patient; that could be related to Notch3 mutation...
2015: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/26195112/-bronchopulmonary-carcinoid-tumors-tunisian-experience-with-115-surgically-treated-cases
#15
A Ayadi-Kaddour, A Marghli, S Zairi, H Zribi, O Ismail, E Braham, S Hantous-Zannad, T Kilani, F El Mezni
INTRODUCTION: Bronchial carcinoid tumors are rare well-differentiated, neuro-endocrine tumors, with low-grade malignancy. They are distinguished in two different groups: typical and atypical carcinoid. The purpose of this study was to review clinical, surgical and pathological characteristics in patients with primary bronchopulmonary carcinoid tumors. METHODS: This retrospective study included 115 bronchial carcinoid tumors surgically treated at a single institution during a twenty-one-year period, between 1992 and 2012...
December 2015: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/26168666/-efficacy-analysis-of-endoscopic-endonasal-transsphenoidal-surgery-for-recurrent-or-regrowing-pituitary-adenomas
#16
Yajun Xue, Yaodong Zhao, Daming Cui, Ke Wang, Zhaoli Shen, Rui Shen, Meiqing Lou
OBJECTIVE: To analyze the safety and efficacy of surgical removal of recurrent or regrowing pituitary adenomas by endoscopic endonasal transsphenoidal approach. METHODS: The clinical data were retrospectively reviewed for 28 patients undergoing endoscopic endonasal transsphenoidal surgery for recurrent or regrowing pituitary adenomas between April 2010 and December 2013. There were 9 males and 19 females with a mean age of 44. 2 (11 - 73) years. The maximal tumor diameter ranged from 2...
February 3, 2015: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/25822436/diagnostic-performance-of-endoscopic-ultrasound-eus-endoscopic-ultrasound-fine-needle-aspiration-eus-fna-cytology-in-solid-and-cystic-pancreatic-neuroendocrine-tumours
#17
COMPARATIVE STUDY
Vikramjit Mitra, Manu K Nayar, John S Leeds, Viney Wadehra, Beate Haugk, John Scott, Richard M Charnley, Kofi W Oppong
BACKGROUND AND AIMS: Our study aimed to assess the sensitivity of EUS and EUS-FNA for pancreatic neuro-endocrine tumors (pNETs) and compare performance over two consecutive 4 year 2 month periods, to investigate the comparative performance between solid and cystic pNETs and determine the incremental yield of EUS +/- FNA in individuals with a mass not diagnosed as a pNET after cross-sectional imaging. METHODS: A retrospective review of a prospectively maintained database was carried out to identify all pNET patients who underwent EUS-FNA between April 2003 and September 2011...
March 2015: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/25779966/prenatal-maternal-immune-activation-increases-anxiety-and-depressive-like-behaviors-in-offspring-with-experimental-autoimmune-encephalomyelitis
#18
J Majidi-Zolbanin, M-H Doosti, M Kosari-Nasab, A-A Salari
Multiple sclerosis (MS) is thought to result from a combination of genetics and environmental factors. Several lines of evidence indicate that significant prevalence of anxiety and depression-related disorders in MS patients can influence the progression of the disease. Although we and others have already reported the consequences of prenatal maternal immune activation on anxiety and depression, less is known about the interplay between maternal inflammation, MS and gender. We here investigated the effects of maternal immune activation with Poly I:C during mid-gestation on the progression of clinical symptoms of experimental autoimmune encephalomyelitis (EAE; a mouse model of MS), and then anxiety- and depressive-like behaviors in non-EAE and EAE-induced offspring were evaluated...
May 21, 2015: Neuroscience
https://www.readbyqxmd.com/read/25732271/duodenum-preserving-total-and-partial-pancreatic-head-resection-for-benign-tumors-systematic-review-and-meta-analysis
#19
REVIEW
Hans G Beger, Akimasa Nakao, Benjamin Mayer, Bertram Poch
BACKGROUND: Potential benefits of local extirpation of benign pancreatic head tumors are tissue conservation of pancreas, stomach, duodenum and common bile duct (CBD) and maintenance of pancreatic functions. METHODS: Medline/PubMed, Embase and Cochrane Library databases were searched to identify studies applying duodenum-preserving total or partial pancreatic-head resection (DPPHRt/p) and reporting short- and long-term outcomes. Twenty-four studies, including 416 patients who underwent DPPHRt/p, were identified for systematic analysis...
March 2015: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/25617076/the-role-of-diffusion-tensor-tractography-in-the-surgical-treatment-of-pediatric-optic-chiasmatic-gliomas
#20
Ming Ge, ShaoWu Li, Liang Wang, ChunDe Li, Junting Zhang
Diffusion tensor tractography(DTT) can theoretically be used in assessing the optic chiasmatic glioma(OCGs),which are still in debate about optimal treatment. The purpose of this study was to investigate the role of this technology in offering more information about the tumor, assisting the debulking surgery, and helping to anticipate visual outcomes. As a prospective cohort study, the enrolled patients received routine pre- and postoperative neuro-ophthalmology, neuroimaging, and endocrine examinations. Fiber tractography was meanwhile performed based on diffusion tensor imaging examination...
April 2015: Journal of Neuro-oncology
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