Eléonore Bettacchioli, Jean-Baptiste Foulquier, Baptiste Chevet, Emilie Cornec-Le Gall, Catherine Hanrotel, Luca Lanfranco, Claire de Moreuil, Yannick Lambert, Maryvonne Dueymes, Nathan Foulquier, Divi Cornec
OBJECTIVES: Anti-neutrophil cytoplasm antibodies (ANCA)-associated vasculitides (AAV) are rare conditions characterized by inflammatory cell infiltration in small blood vessels, leading to tissue necrosis. While most patients with AAV present antibodies against either myeloperoxidase (MPO) or proteinase 3 (PR3), rare cases of dual positivity for both antibodies (DP-ANCA) have been reported, and their impact on the clinical picture remains unclear. The goal of this study was to investigate the clinical implications, phenotypic profiles, and outcomes of patients with DP-ANCA...
March 29, 2024: Rheumatology