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https://www.readbyqxmd.com/read/29042023/selective-embolization-of-the-superior-rectal-artery-an-alternative-to-hemorrhoid-surgery
#1
Vicent Primo Romaguera, Abel Gregorio Hernández, Luís Andreo Hernández, Eduardo de la Morena Valenzuela
No abstract text is available yet for this article.
October 14, 2017: Cirugía Española
https://www.readbyqxmd.com/read/28992696/hybrid-all-atom-coarse-grained-simulations-of-proteins-by-direct-coupling-of-charmm-and-primo-force-fields
#2
Parimal Kar, Michael Feig
Hybrid all-atom/coarse-grained (AA/CG) simulations of proteins offer a computationally efficient compromise where atomistic details are only applied to biologically relevant regions while benefiting from the speedup of treating the remaining parts of a given system at the CG level. The recently developed CG model, PRIMO, allows a direct coupling with an atomistic force field with no additional modifications or coupling terms and the ability to carry out dynamic simulations without any restraints on secondary or tertiary structures...
October 19, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28987022/debate-on-defining-melancholia-a-core-mood-disorder
#3
Lucas Primo de Carvalho Alves, Neusa Sica da Rocha
OBJECTIVES: Recently, a debate article by Parker et al. was published regarding the biological type of depression, melancholia, in which they discussed its clinical presentation, particularly that involving psychomotor disturbances. However, there is one feature of melancholia that is frequently forgotten, to which this article aims to devote special attention: ruminative thoughts of guilt. METHODS: A critical review of the literature. RESULTS: The symptom of ruminative thoughts of guilt has been described historically in melancholia, and some recent data, such as neurobiological abnormalities and poor prognosis, support it as an important feature of depression...
October 7, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28966887/rootstock-influence-on-iron-uptake-responses-in-citrus-leaves-and-their-regulation-under-the-fe-paradox-effect
#4
Mary-Rus Martinez-Cuenca, Amparo Primo-Capella, Ana Quiñones, Almudena Bermejo, Maria Angeles Forner-Giner
BACKGROUND AND AIMS: This work evaluates the regulation of iron uptake responses in Citrus leaves and their involvement in the Fe paradox effect. METHODS: Experiments were performed in field-grown 'Navelina' trees grafted onto two Cleopatra mandarin × Poncirus trifoliata (L.) Raf. hybrids with different Fe-chlorosis symptoms: 030146 (non-chlorotic) and 030122 (chlorotic). RESULTS: Chlorotic leaves were smaller than non-chlorotic ones for both dry weight (DW) and area basis, and exhibited marked photosynthetic state affection, but reduced catalase and peroxidase enzymatic activities...
2017: PeerJ
https://www.readbyqxmd.com/read/28914254/homeopathic-therapy-for-sleep-bruxism-in-a-child-findings-of-a-2-year-case-report
#5
Claudia Tavares Silva, Laura Guimarães Primo, Adrielle Mangabeira, Lucianne Cople Maia, Andrea Fonseca-Gonçalves
Bruxism is a sleep disorder characterized by grinding and biting teeth with multifactorial etiology, resulting in deleterious effects on teeth, periodontium, and temporomandibular joint. There is a lack of scientific evidence evaluating the effectiveness of medicines in treating this parafunction. The present case report was drafted under the rules of CARE checklist. An 8-year-old male patient with sleep bruxism and associated symptoms received a combined homeopathic therapy of Phytolacca decandra 12c and Melissa officinalis 12c for 2 months...
October 2017: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/28902257/sustainability-in-orthodontics-what-can-we-do-to-save-our-planet
#6
Matheus Melo Pithon, Lucianne Cople Maia de Faria, Orlando Motohiro Tanaka, Antônio Carlos de Oliveira Ruellas, Laura Salignac de Souza Guimarães Primo
The sustainability of the natural resources of our planet is a topic for worldwide debate. Mankind, during its evolution as a species, has not been greatly concerned about conserving the environment in which we live. Nowadays we are reaping the fruits of this neglect. Climatic changes and storms are good examples of this. We, humans, must re-think our attitudes in order to leave the planet in a healthy state to be used by our descendants. But thinking of orthodontics, what can we do as orthodontists? From this perspective, the authors of the present study aimed, in a clear and objective manner, to present simple and sustainable ways to proceed during our activity as orthodontists, in order to minimize the effects on nature, caused by man...
July 2017: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/28895540/polymorphism-rs3123554-in-the-cannabinoid-receptor-gene-type-2-cnr2-reveals-effects-on-body-weight-and-insulin-resistance-in-obese-subjects
#7
Daniel Antonio de Luis, Olatz Izaola, David Primo, Beatriz de la Fuente, Rocio Aller
BACKGROUND: Few studies assessing the relationship between single nucleotide polymorphisms in CNR2 and obesity or its related metabolic parameters are available. OBJECTIVE: To investigate the influence of polymorphism rs3123554 in the CNR2 receptor gene on obesity anthropometric parameters, insulin resistance, and adipokines in subjects with obesity. DESIGN: The study population consisted of 1027 obese subjects, who were performed bioelectrical impedance analyses, blood pressure measurements, serial assessments of dietary intake during three days, and biochemical tests...
October 2017: Endocrinología, diabetes y nutrición
https://www.readbyqxmd.com/read/28892233/hyaluronic-acid-microneedle-patch-for-the-improvement-of-crow-s-feet-wrinkles
#8
Sun Young Choi, Hyun Jung Kwon, Ga Ram Ahn, Eun Jung Ko, Kwang Ho Yoo, Beom Joon Kim, Changjin Lee, Daegun Kim
Hyaluronic acid (HA) has an immediate volumizing effect, due to its strong water-binding potential, and stimulates fibroblasts, causing collagen synthesis, with short- and long-term effects on wrinkle improvement. We investigated the efficacy and safety of HA microneedle patches for crow's feet wrinkles. Using a randomized spilt-face design, we compared microneedle patches with a topical application containing the same active ingredients. We enrolled 34 Korean female subjects with mild to moderate crow's feet wrinkles...
September 11, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28871259/syphilis-infection-differentially-regulates-the-phenotype-and-function-of-%C3%AE-%C3%AE-t-cells-in-hiv-1-infected-patients-depends-on-the-hiv-1-disease-stage
#9
Zhen Li, Xiaofan Lu, Zhiliang Hu, Zhenwu Luo, Wei Jiang, Hao Wu, Yanqing Gao, Junling Yan, Qiuyue Zhang, Aixin Song, Xiaojie Huang, Danlei Mou, Bin Su, Tong Zhang
A rapidly escalating outbreak of syphilis infection has been affected men who have sex with men, particularly those with HIV-1 infection. γδ T cells are unconventional immune cells with two main subsets, Vδ1 T cells and Vδ2 T cells, which possess a combination of innate and adaptive immune features allowing them against HIV-1. However, whether syphilis infection affects the phenotype and function of γδ T cells in HIV-1-infected patients remains unclear, especially in acute HIV-1 infection (AHI). In this study, we enrolled 57 HIV-1-infected patients (24 with HIV-1 infection only and 33 coinfected with syphilis) from an acute HIV-1-infected cohort in Beijing (PRIMO)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28869073/association-of-the-rs10830963-polymorphism-in-melatonin-receptor-type-1b-mtnr1b-with-metabolic-response-after-weight-loss-secondary-to-a-hypocaloric-diet-based-in-mediterranean-style
#10
Daniel Antonio de Luis, Olatz Izaola, David Primo, R Aller
BACKGROUND & AIMS: Some genetic variants within MTNR1B were related with fasting glucose levels or the increased prevalence of diabetes mellitus and obesity. The aims of the present investigation were to determine the influence of rs10830963 MTNR1B variant in relation to body weight loss, insulin resistance and adipokine levels in response to a hypocaloric diet with Mediterranean pattern. METHODS: A Caucasian population of 80 obese patients was studied before and after 12 weeks on a hypocaloric diet...
August 23, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28856147/anti-cardiac-troponin-antibodies-in-clinical-human-disease-a-systematic-review
#11
REVIEW
Eduardo M Vilela, Rita Bettencourt-Silva, J Torres da Costa, Ana Raquel Barbosa, Marisa P Silva, Madalena Teixeira, João Primo, Vasco Gama Ribeiro, José Pedro L Nunes
Anti-cardiac troponin antibodies have been studied in different types of clinical diseases and in healthy populations. A systematic review of published data on anti-troponin antibodies was carried out (search performed on PubMed, ISI Web of Knowledge and Scopus databases). From title and abstract analysis, thirty-three articles were included that met the pre-specified criteria; after full-text analysis, nine articles were excluded. Most studies assessed anti-troponin I antibodies. The prevalence of anti-cardiac troponin antibodies in healthy individuals ranged from 0...
August 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28855635/highly-efficient-dna-free-gene-disruption-in-the-agricultural-pest-ceratitis-capitata-by-crispr-cas9-ribonucleoprotein-complexes
#12
Angela Meccariello, Simona Maria Monti, Alessandra Romanelli, Rita Colonna, Pasquale Primo, Maria Grazia Inghilterra, Giuseppe Del Corsano, Antonio Ramaglia, Giovanni Iazzetti, Antonia Chiarore, Francesco Patti, Svenia D Heinze, Marco Salvemini, Helen Lindsay, Elena Chiavacci, Alexa Burger, Mark D Robinson, Christian Mosimann, Daniel Bopp, Giuseppe Saccone
The Mediterranean fruitfly Ceratitis capitata (medfly) is an invasive agricultural pest of high economic impact and has become an emerging model for developing new genetic control strategies as an alternative to insecticides. Here, we report the successful adaptation of CRISPR-Cas9-based gene disruption in the medfly by injecting in vitro pre-assembled, solubilized Cas9 ribonucleoprotein complexes (RNPs) loaded with gene-specific single guide RNAs (sgRNA) into early embryos. When targeting the eye pigmentation gene white eye (we), a high rate of somatic mosaicism in surviving G0 adults was observed...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28844528/association-between-implantation-depth-assessed-by-computed-tomography-and-new-onset-conduction-disturbances-after-transcatheter-aortic-valve-implantation
#13
João Gonçalves Almeida, Sara Moura Ferreira, Paulo Fonseca, Tiago Dias, Cláudio Guerreiro, Ana Raquel Barbosa, Pedro Teixeira, Mónica Carvalho, Wilson Ferreira, Nuno Dias Ferreira, Marco Oliveira, Helena Gonçalves, Pedro Braga, José Ribeiro, João Primo, Vasco Gama Ribeiro
BACKGROUND: Transcatheter aortic valve replacement (TAVR) is often associated with intraventricular conduction disturbances. We aimed to determine the association between implantation depth assessed by multidetector computed tomography (MDCT) and new-onset conduction abnormalities after TAVR. METHODS: Retrospective single-center study including patients consecutively submitted to TAVR, between August/2007 and October/2016, who underwent routine MDCT 3 months after the procedure...
August 18, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28841654/inter-laboratory-agreement-on-embryo-classification-and-clinical-decision-conventional-morphological-assessment-vs-time-lapse
#14
Luis Martínez-Granados, María Serrano, Antonio González-Utor, Nereyda Ortíz, Vicente Badajoz, Enrique Olaya, Nicolás Prados, Montse Boada, Jose A Castilla
The aim of this study is to determine inter-laboratory variability on embryo assessment using time-lapse platform and conventional morphological assessment. This study compares the data obtained from a pilot study of external quality control (EQC) of time lapse, performed in 2014, with the classical EQC of the Spanish Society for the Study of Reproductive Biology (ASEBIR) performed in 2013 and 2014. In total, 24 laboratories (8 using EmbryoScope™, 15 using Primo Vision™ and one with both platforms) took part in the pilot study...
2017: PloS One
https://www.readbyqxmd.com/read/28838760/in-vitro-assessment-of-anti-tumorigenic-mechanisms-and-efficacy-of-nanoala-a-nanoformulation-of-aminolevulic-acid-designed-for-photodynamic-therapy-of-cancer
#15
Laise Rodrigues de Andrade, Fernando Lucas Primo, Jaqueline Rodrigues da Silva, Antonio Claudio Tedesco, Zulmira Guerrero Marques Lacava
BACKGROUND: The development of nanocarriers is an important approach to increase the bioavailability of hydrophilic drugs in target cells. In this work, we evaluated the anti-tumorigenic mechanisms and efficacy of NanoALA, a novel nanoformulation of aminolevulic acid (ALA) based on poly(lactide-co-glycolide) (PLGA) nanocapsules designed for anticancer photodynamic therapy (PDT). METHODS: For this purpose, physicochemical characterization, prodrug incorporation kinetics, biocompatibility and photocytotoxicity tests, analysis of the cell death type and mitochondrial function, measurement of the intracellular reactive oxygen species production and DNA fragmentation were performed in murine mammary carcinoma (4T1) cells...
August 21, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28832978/bevacizumab-alone-or-in-combination-with-trc105-for-patients-with-refractory-metastatic-renal-cell-cancer
#16
Tanya B Dorff, Jeff A Longmate, Sumanta K Pal, Walter M Stadler, Mayer N Fishman, Ulka N Vaishampayan, Amol Rao, Jacek K Pinksi, James S Hu, David I Quinn, Primo N Lara
BACKGROUND: Targeting the vascular endothelial growth factor (VEGF) pathway has improved outcomes in metastatic renal cell carcinoma (RCC); however, resistance inevitably occurs. CD105 (endoglin) is an angiogenic pathway that is strongly upregulated after VEGF inhibition, potentially contributing to resistance. The authors tested whether TRC105, a monoclonal antibody against endoglin, impacted disease control in patients with previously treated RCC who were receiving bevacizumab. METHODS: Eligible patients with metastatic RCC who had previously received 1 to 4 prior lines of therapy, including VEGF-targeted agents, were randomized 1:1 to receive bevacizumab 10 mg/kg intravenously every 2 weeks (arm A) or the same plus TRC105 10 mg/kg intravenously every 2 weeks (arm B)...
August 22, 2017: Cancer
https://www.readbyqxmd.com/read/28823025/nanomedicine-associated-with-photodynamic-therapy-for-glioblastoma-treatment
#17
REVIEW
Leonardo B de Paula, Fernando L Primo, Antonio C Tedesco
Glioblastoma, also known as glioblastoma multiforme (GBM), is the most recurrent and malignant astrocytic glioma found in adults. Biologically, GBMs are highly aggressive tumors that often show diffuse infiltration of the brain parenchyma, making complete surgical resection difficult. GBM is not curable with surgery alone because tumor cells typically invade the surrounding brain, rendering complete resection unsafe. Consequently, present-day therapy for malignant glioma remains a great challenge. The location of the invasive tumor cells presents several barriers to therapeutic delivery...
August 19, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28817973/the-agma1-polyamidoamine-mediates-the-efficient-delivery-of-sirna
#18
Roberta Cavalli, Luca Primo, Roberto Sessa, Giulia Chiaverina, Laura di Blasio, Jenny Alongi, Amedea Manfredi, Elisabetta Ranucci, Paolo Ferruti
AGMA1, a prevailingly cationic, guanidine-bearing, linear, amphoteric polyamidoamine is an effective siRNA condensing agent. Here two AGMA1 samples of different molecular weight, i.e. AGMA1-5 and AGMA1-10 were evaluated as siRNA condensing agents and transfection promoters. AGMA1-10 formed stable polyplexes with a size lower than 50 nm and positive zeta potential. AGMA1-5 polyplexes were larger, about 100 nm in size. AGMA1-10 polyplexes, but not AGMA1-5 proved to be an effective intracellular siRNA carrier, able to trigger gene silencing in Hela and PC3 cell lines without eliciting cytotoxic effects...
August 18, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28807606/effectiveness-of-different-vaccine-schedules-for-heptavalent-and-13-valent-conjugate-vaccines-against-pneumococcal-disease-in-the-community-of-madrid
#19
P Latasa, M Ordobás, M Garrido-Estepa, A Gil de Miguel, J C Sanz, M D Barranco, E Insúa, L García-Comas
INTRODUCTION: The heptavalent pneumococcal conjugate vaccine (PCV-7) was added to the childhood routine vaccination program in the Community of Madrid in November of 2006 with 3+1 recommended doses and a catch-up for those under 2years old. In June 2010, PCV-7 was replaced by 13-valent vaccine (PCV-13) with 2+1 recommended doses. In July of 2012, the PCV-13 was removed from the funded program and reintroduced again (2+1 recommended doses) in December 2014. In between, children were vaccinated privately with 3+1 recommended doses of PCV-13...
September 25, 2017: Vaccine
https://www.readbyqxmd.com/read/28791946/pseudomonas-aeruginosa-gbdr-gene-is-transcribed-from-a-%C3%AF-54-dependent-promoter-under-the-control-of-ntrc-cbrb-ihf-and-beti
#20
Diego Germán Sánchez, Emiliano David Primo, María Teresa Damiani, Angela Teresita Lisa
Pseudomonasaeruginosa uses choline as a source of carbon and nitrogen, and also for the synthesis of glycine betaine, an osmoprotectant under stress conditions such as drought and salinity. The transcription factor GbdR is the specific regulator of choline metabolism and it belongs to the Arac/XylS family of transcriptional regulators. Despite the link between choline catabolism and bacterial pathogenicity, gbdR regulation has not been explored in detail. In the present work, we describe how gbdR transcription can be initiated from a σ54-dependent promoter...
August 9, 2017: Microbiology
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