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https://www.readbyqxmd.com/read/28823025/nanomedicine-associated-with-photodynamic-therapy-for-glioblastoma-treatment
#1
REVIEW
Leonardo B de Paula, Fernando L Primo, Antonio C Tedesco
Glioblastoma, also known as glioblastoma multiforme (GBM), is the most recurrent and malignant astrocytic glioma found in adults. Biologically, GBMs are highly aggressive tumors that often show diffuse infiltration of the brain parenchyma, making complete surgical resection difficult. GBM is not curable with surgery alone because tumor cells typically invade the surrounding brain, rendering complete resection unsafe. Consequently, present-day therapy for malignant glioma remains a great challenge. The location of the invasive tumor cells presents several barriers to therapeutic delivery...
August 19, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28817973/the-agma1-polyamidoamine-mediates-the-efficient-delivery-of-sirna
#2
Roberta Cavalli, Luca Primo, Roberto Sessa, Giulia Chiaverina, Laura di Blasio, Jenny Alongi, Amedea Manfredi, Elisabetta Ranucci, Paolo Ferruti
AGMA1, a prevailingly cationic, guanidine-bearing, linear, amphoteric polyamidoamine is an effective siRNA condensing agent. Here two AGMA1 samples of different molecular weight, i.e. AGMA1-5 and AGMA1-10 were evaluated as siRNA condensing agents and transfection promoters. AGMA1-10 formed stable polyplexes with a size lower than 50 nm and positive zeta potential. AGMA1-5 polyplexes were larger, about 100 nm in size. AGMA1-10 polyplexes, but not AGMA1-5 proved to be an effective intracellular siRNA carrier, able to trigger gene silencing in Hela and PC3 cell lines without eliciting cytotoxic effects...
August 18, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28807606/effectiveness-of-different-vaccine-schedules-for-heptavalent-and-13-valent-conjugate-vaccines-against-pneumococcal-disease-in-the-community-of-madrid
#3
P Latasa, M Ordobás, M Garrido-Estepa, A Gil de Miguel, J C Sanz, M D Barranco, E Insúa, L García-Comas
INTRODUCTION: The heptavalent pneumococcal conjugate vaccine (PCV-7) was added to the childhood routine vaccination program in the Community of Madrid in November of 2006 with 3+1 recommended doses and a catch-up for those under 2years old. In June 2010, PCV-7 was replaced by 13-valent vaccine (PCV-13) with 2+1 recommended doses. In July of 2012, the PCV-13 was removed from the funded program and reintroduced again (2+1 recommended doses) in December 2014. In between, children were vaccinated privately with 3+1 recommended doses of PCV-13...
August 11, 2017: Vaccine
https://www.readbyqxmd.com/read/28781838/acute-pancreatitis-in-immunocompromised-patients-beware-of-varicella-zoster-virus-primo-infection
#4
Adrien Picod, Elise Corre, Eric Maury, Paul Duriez, Nadia Hoyeau, Paul Coppo
Varicella zoster virus (VZV) primo-infection can be severe in the elderly and in immunocompromised patients. Atypical presentations are not uncommon and may mislead the diagnosis and delay adequate treatment. Valacyclovir prophylaxis should be systematically proposed in immunocompromised patients.
August 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28769972/the-first-molecular-identification-of-an-olive-collection-applying-standard-simple-sequence-repeats-and-novel-expressed-sequence-tag-markers
#5
Soraya Mousavi, Roberto Mariotti, Luca Regni, Luigi Nasini, Marina Bufacchi, Saverio Pandolfi, Luciana Baldoni, Primo Proietti
Germplasm collections of tree crop species represent fundamental tools for conservation of diversity and key steps for its characterization and evaluation. For the olive tree, several collections were created all over the world, but only few of them have been fully characterized and molecularly identified. The olive collection of Perugia University (UNIPG), established in the years' 60, represents one of the first attempts to gather and safeguard olive diversity, keeping together cultivars from different countries...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28736761/phase-ii-study-of-dovitinib-in-patients-progressing-on-anti-vascular-endothelial-growth-factor-therapy
#6
Thomas J Semrad, Edward J Kim, Michael S Tanaka, Jacob Sands, Chris Roberts, Rebekah A Burich, Yu Li, David R Gandara, Primo Lara, Philip C Mack
BACKGROUND: Prior work identified the fibroblast growth factor (FGF) pathway as a mediator of resistance to anti-vascular endothelial growth factor (VEGF) therapy. We tested dovitinib, an inhibitor of both FGF and VEGF receptors, in patients progressing on anti-VEGF treatment. METHODS: Patients with measurable advanced colorectal or non-small cell lung cancer with progression despite anti-VEGF treatment within 56 days, good performance status and adequate organ function were eligible...
2017: Cancer Treat Res Commun
https://www.readbyqxmd.com/read/28709762/prevalence-of-paroxysmal-atrial-fibrillation-in-a-population-assessed-by-continuous-24-hour-monitoring
#7
João Primo, Helena Gonçalves, Ana Macedo, Paula Russo, Telma Monteiro, João Guimarães, Ovídio Costa
INTRODUCTION: Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice and a major cause of morbidity, due to the associated risk of stroke. However, since it is often paroxysmal, it is commonly underdiagnosed and undertreated. OBJECTIVES: The primary objective of this prospective study was to determine the prevalence of paroxysmal atrial fibrillation (PAF) in patients aged 40 and above in a population who underwent continuous 24-hour electrocardiographic monitoring...
July 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/28701736/epibiotic-pressure-contributes-to-biofouling-invader-success
#8
Kaeden Leonard, Chad L Hewitt, Marnie L Campbell, Carmen Primo, Steven D Miller
Reduced competition is a frequent explanation for the success of many introduced species. In benthic marine biofouling communities, space limitation leads to high rates of overgrowth competition. Some species can utilise other living organisms as substrate (epibiosis), proffering a competitive advantage for the epibiont. Additionally, some species can prevent or reduce epibiotic settlement on their surfaces and avoid being basibionts. To test whether epibiotic pressure differs between native and introduced species, we undertook ex situ experiments comparing bryozoan larval settlement to determine if introduced species demonstrate a greater propensity to settle as epibionts, and a reduced propensity to be basibionts, than native species...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28692074/-prima-guerra-mondiale-e-salute-mentale-uno-studio-retrospettivo-su-veterani-ricoverati-in-un-ospedale-psichiatrico-tra-il-1915-e-il-1918
#9
Paolo Lagonia, Matteo Aloi, Fabio Magliocco, Gregorio Cerminara, Cristina Segura-Garcia, Valeria Del Vecchio, Mario Luciano, Andrea Fiorillo, Pasquale De Fazio
RIASSUNTO. Scopo. L'associazione tra malattia mentale e guerra è stata più volte indagata. Nei reduci sono stati riscontrati alti livelli di sintomi depressivi e un aumento del rischio di suicidio. In questo studio abbiamo indagato le condizioni di salute mentale dei soldati italiani che hanno partecipato alla "Grande Guerra" che sono stati ricoverati in un Ospedale Psichiatrico in Italia. Metodi. Il campione è composto da 498 soldati ospedalizzati durante la prima guerra mondiale tra il 1915 e il 1918, e 498 pazienti civili ricoverati in due diversi periodi (1898-1914, 1919-1932)...
May 2017: Rivista di Psichiatria
https://www.readbyqxmd.com/read/28685472/potential-erythropoiesis-in-the-primo-vascular-system-in-heart-failure
#10
Chae Jeong Lim, Yiming Shen, So Yeong Lee, Pan Dong Ryu
The primo-vascular system (PVS), composed of primo-nodes (PNs) and primo-vessels (PVs), has been identified in various animal models. However, little is known about its function. Here, we investigated the changes in gross morphology and cellular composition of the organ-surface PVS (osPVS) in rats with heart failure (HF) induced by myocardial infarction. The size of the PNs in rats with HF was larger than in sham rats (1.87 vs. 0.80 mm(2); P < 0.01) and the density of osPVS per rat was greater for the HF rats (28 of 6 rats vs...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28679670/psoriasiform-skin-disease-in-transgenic-pigs-with-high-copy-ectopic-expression-of-human-integrins-%C3%AE-2-and-%C3%AE-1
#11
Nicklas Heine Staunstrup, Karin Stenderup, Sidsel Mortensen, Maria Nascimento Primo, Cecilia Rosada, Torben Steiniche, Ying Liu, Rong Li, Mette Schmidt, Stig Purup, Frederik Dagnæs-Hansen, Lisbeth Dahl Schrøder, Lars Svensson, Thomas Kongstad Petersen, Henrik Callesen, Lars Bolund, Jacob Giehm Mikkelsen
Psoriasis is a complex human-specific disease characterized by perturbed keratinocyte proliferation and a pro-inflammatory environment in the skin. Porcine skin architecture and immunity are very similar to that in humans, rendering the pig a suitable animal model for studying the biology and treatment of psoriasis. Expression of integrins, which is normally confined to the basal layer of the epidermis, is maintained in suprabasal keratinocytes in psoriatic skin, modulating proliferation and differentiation as well as leukocyte infiltration...
July 1, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28666606/gastrointestinal-bleeding-caused-by-neurofibroma-of-the-ileum
#12
Cristina Samartín Toimil, Ana María Gay Fernández, Antoni Tardío Baiges, Juan Carlos Primo Álvarez, Jose Enrique Casal Núñez
No abstract text is available yet for this article.
June 27, 2017: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/28633670/preclinical-anti-myeloma-activity-of-edo-s101-a-new-bendamustine-derived-molecule-with-added-hdaci-activity-through-potent-dna-damage-induction-and-impairment-of-dna-repair
#13
Ana-Alicia López-Iglesias, Ana B Herrero, Marta Chesi, Laura San-Segundo, Lorena González-Méndez, Susana Hernández-García, Irena Misiewicz-Krzeminska, Dalia Quwaider, Montserrat Martín-Sánchez, Daniel Primo, Teresa Paíno, P Leif Bergsagel, Thomas Mehrling, Marcos González-Díaz, Jesús F San-Miguel, María-Victoria Mateos, Norma C Gutiérrez, Mercedes Garayoa, Enrique M Ocio
BACKGROUND: Despite recent advances in the treatment of multiple myeloma (MM), the prognosis of most patients remains poor, and resistance to traditional and new drugs frequently occurs. EDO-S101 is a novel therapeutic agent conceived as the fusion of a histone deacetylase inhibitor radical to bendamustine, with the aim of potentiating its alkylating activity. METHODS: The efficacy of EDO-S101 was evaluated in vitro, ex vivo and in vivo, alone, and in combination with standard anti-myeloma agents...
June 20, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28631774/-il-ruolo-di-niraparib-nel-trattamento-del-carcinoma-ovarico-attualit%C3%A3-e-prospettive
#14
Ilaria Sabatucci, Domenica Lorusso
Riassunto. I PARP inibitori interferiscono con la riparazione del danno nella singola elica del DNA determinando una progressione del difetto nella doppia elica. In circa il 50% delle pazienti con carcinoma dell'ovaio sieroso di alto grado sono presenti difetti nei meccanismi di ricombinazione omologa, deputati alla riparazione del danno della doppia elica del DNA. L'incapacità di riparare il danno si traduce nella morte cellulare, un processo definito "letalità sintetica". Nella famiglia dei PARP inibitori il niraparib è stato il primo a essere approvato dalla FDA nel trattamento delle pazienti con carcinoma ovarico ricorrente indipendentemente dalla presenza o assenza di mutazioni BRCA...
June 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28629673/a-comparison-of-two-clinical-scores-for-bronchiolitis-a-multicentre-and-prospective-study-conducted-in-hospitalised-infants
#15
C Rivas-Juesas, J M Rius Peris, A L García, A A Madramany, M G Peris, L V Álvarez, J Primo
BACKGROUND: There are a number of clinical scores for bronchiolitis but none of them are firmly recommended in the guidelines. METHOD: We designed a study to compare two scales of bronchiolitis (ESBA and Wood Downes Ferres) and determine which of them better predicts the severity. A multicentre prospective study with patients <12 months with acute bronchiolitis was conducted. Each patient was assessed with the two scales when admission was decided. We created a new variable "severe condition" to determine whether one scale afforded better discrimination of severity...
June 16, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28619144/recombinant-human-adenovirus-5-expressing-capsid-proteins-of-indian-vaccine-strains-of-foot-and-mouth-disease-virus-elicits-effective-antibody-response-in-cattle
#16
B P Sreenivasa, J K Mohapatra, S J Pauszek, M Koster, V C Dhanya, R P Tamil Selvan, M Hosamani, P Saravanan, Suresh H Basagoudanavar, T de Los Santos, R Venkataramanan, L L Rodriguez, M J Grubman
Recombinant adenovirus-5 vectored foot-and-mouth disease constructs (Ad5- FMD) were made for three Indian vaccine virus serotypes O, A and Asia 1. Constructs co-expressing foot-and- mouth disease virus (FMDV) capsid and viral 3C protease sequences, were evaluated for their ability to induce a neutralizing antibody response in indigenous cattle (Bos indicus). Purified Ad5-FMD viruses were inoculated in cattle as monovalent (5×10(9) pfu/animal) or trivalent (5×10(9) pfu/animal per serotype) vaccines. Animals vaccinated with monovalent Ad5-FMD vaccines were boosted 63days later with the same dose...
May 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28601987/the-association-of-snp276g-t-at-adiponectin-gene-with-insulin-resistance-and-circulating-adiponectin-in-morbid-obese-patients-after-a-biliopancreatic-diversion-surgery
#17
Daniel Antonio de Luis, David Pacheco, D Primo, Olatz Izaola, R Aller
BACKGROUND: The effects of rs1501299 variant of ADIPO gene on weight loss after bariatric surgery have not been evaluated. We decided to investigate the role of this genetic variant on anthropometric and biochemical outcomes such as serum adiponectin levels after biliopancreatic diversion (BPD) surgery in morbidly obese patients during 3 years. MATERIAL AND METHODS: A sample of 64 patients with morbid obesity without diabetes mellitus was operated. Biochemical and anthropometric evaluation were realized at basal visit and at each visit during 3 years (1, 2, and 3 years)...
June 11, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28599959/photodynamic-process-induced-by-chloro-aluminum-phthalocyanine-nanoemulsion-in-glioblastoma
#18
Andrielle Castilho-Fernandes, Tácila G Lopes, Fernando L Primo, Marcelo R Pinto, Antonio C Tedesco
BACKGROUND: Glioblastoma multiforme (GBM) is a tumor characterized by rapid cell proliferation and migration. GBM constitutes the most aggressive and deadly type of brain tumor and is classified into several subtypes that show high resistance to conventional therapies. There are currently no curative treatments for malignant glioma despite the numerous advances in surgical techniques, radiotherapy, and chemotherapy. Therefore, alternative approaches are required to improve GBM treatment...
June 6, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28595187/rs10767664-gene-variant-in-brain-derived-neurotrophic-factor-is-associated-with-diabetes-mellitus-type-2-in-caucasian-females-with-obesity
#19
Daniel Antonio de Luis, Rocío Aller, Olatz Izaola, David Primo, Enrique Romero
BACKGROUND: The role of brain-derived neurotrophic factor (BDNF) variants on diabetes prevalence, basal adipokine levels, body weight, and cardiovascular risk factors remains unclear in obese patients. OBJECTIVE: This study is aimed at analyzing the effects of rs10767664 BDNF gene polymorphism on diabetes mellitus prevalence, body weight, cardiovascular risk factors, and serum adipokine levels in obese female patients. DESIGN: A total of 507 obese women were enrolled in a prospective way...
2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28580816/can-the-enterococcus-faecalis-identified-in-the-root-canals-of-primary-teeth-be-a-cause-of-failure-of-endodontic-treatment
#20
Viviane Cancio, Dennis de Carvalho Ferreira, Fernanda Sampaio Cavalcante, Alexandre Soares Rosado, Lúcia Martins Teixeira, Queila Braga Oliveira, Roberta Barcelos, Rogerio Gleiser, Henrique Fragoso Santos, Kátia Regina Netto Dos Santos, Laura Guimarães Primo
OBJECTIVE: This study investigated the presence of Enterococcus faecalis in primary teeth with primary root canal infections and related to the possible failure of pulpectomy outcome after 36 months. MATERIAL AND METHODS: Root canal samples were obtained from 25 out of 244 patients using the sterile paper cone method. The identification of E. faecalis was done with culture and molecular tests using species-specific 16S rRNA gene-based polymerase chain reaction (PCR)...
August 2017: Acta Odontologica Scandinavica
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