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Ivan Esteve-Adell, Jinbao He, Fernando Ramiro, Pedro Atienzar, Ana Primo, Hermenegildo García
A procedure for the one-step preparation of films of few-layer N-doped graphene on top of nanometric hexagonal boron nitride sheets ((N)graphene/h-BN) based on the pyrolysis at 900 °C under an inert atmosphere of a film of chitosan containing about 20 wt% of ammonium borate salt as a precursor is reported. During the pyrolysis a spontaneous segregation of (N)graphene and boron nitride layers takes place. The films were characterized by optical microscopy that shows a thin graphene overlayer covering the boron nitride layer, the latter showing characteristic cracks, and by XPS measurements at different monitoring angles from 0° to 50° where an increase in the proportion of C vs...
February 16, 2018: Nanoscale
Myron Nevins, Stefano Parma-Benfenati, Cosmin Sava, Catalin Sava, Franco Quinti, Primo Galletti, Gerardo Mendoza-Azpur, Erik Valdivia, Yong-Han Koo, David M Kim
The goal of this investigation was to evaluate the bone-to-implant contact (BIC) of dental implants placed into fresh extraction sockets without pre-existing periapical pathology. When the extraction sites exhibited a gap distance of > 2 mm, autogenous bone harvested from surrounding surgical sites was grafted to fill that gap with no barrier membranes. All implants were clinically stable and successful at 6 months postoperative. The histologic examination demonstrated an average of 66.2% BIC for all five immediately placed dental implants...
March 2018: International Journal of Periodontics & Restorative Dentistry
Andréa V Pintor, Marcello R Santos, Laura S Guimarães Primo
No abstract text is available yet for this article.
April 2018: Minerva Stomatologica
Valéria Ferreira-Silva, Fernando L Primo, Munira M A Baqui, Danielle A R Magalhães, Maristela D Orellana, Andrielle Castilho-Fernandes, Mario C Cruz, Niehls O S Câmara, Dimas T Covas, Antonio C Tedesco
The purpose of the present study was to evaluate the neural protein expression pattern of human multipotent mesenchymal stromal cells (hMSCs) treated with forskolin (free-form/FF). The study investigated forskolin's capacity to enhance intracellular levels of cyclic adenosine monophosphate (cAMP) by activating adenylate cyclase and probably by inducing neuron-like cells in vitro. In addition, because nanotechnology is a growing field of tissue engineering, we also assessed the action of a new system called the nanostructured-forskolin (NF) to examine the improvement of drug delivery...
February 13, 2018: Stem Cell Reviews
Mathilde Bahuaud, Constance Beaudouin-Bazire, Marine Husson, Anna Molto, Odile Launay, Frédéric Batteux, Maxime Dougados
OBJECTIVES: Patients with rheumatoid arthritis (RA) are at an increased risk of Pneumococcal infections. Immunogenicity and persistence of a prime-boost revaccination strategy using 13-valent/23-valent anti-pneumococcal vaccines was evaluated in patients with RA treated by Methotrexate (MTX) and anti-TNF. METHOD: Twenty-four patients with RA received one dose of PCV13 (Prevenar13ࣨ; Pfizer) followed two months later by one dose of PPV23 (Pneumovax®, Merck). Concentrations of IgG specific for 7 serotypes common to both vaccines and 3 uncommon serotypes, included only in the PPV23 were measured by ELISA and Opsonophagocytic Assay (OPA) at baseline and after 4, 12 and 24 months post-vaccine...
February 12, 2018: Human Vaccines & Immunotherapeutics
Eduardo M Vilela, José Ribeiro, João Almeida, Marlene Fonseca, Adelaide Dias, João Primo, Pedro Braga, Vasco Gama
Functional tricuspid regurgitation is a prevalent disease, especially among patients with other valve disorders, and is associated with significant morbidity and mortality. Its management is challenging, and many patients deemed at high surgical risk are managed conservatively. Despite optimization of pharmacological treatment, many patients continue to be symptomatic, thus leading to interest in percutaneous interventional techniques. The Mitralign system has recently been used for the treatment of functional tricuspid regurgitation, with favorable clinical and imaging results...
February 4, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
Sandra Cristina de Alvarenga, Denise Silveira de Castro, Franciéle Marabotti Costa Leite, Telma Ribeiro Garcia, Marcos Antônio Gomes Brandão, Cândida Caniçali Primo
OBJECTIVE: To investigate the Nursing diagnostic accuracy measures and to propose a model to use defining characteristics in order to judge the nursing diagnosis of ineffective breastfeeding. METHOD: Cross-sectional study with a sample of 73 binomials mom-child hospitalized in a maternity ward of an University Hospital, from July to August of 2014. RESULTS: The diagnostic predominance rate was 58.9%. The characteristics that best meet the needs of logistic regression model were: discontinuance of breast sucking; infant's inability of seizing the areola-nipple region correctly; infant's crying one hour after breastfeeding and inappropriate milk supply perceived...
March 2018: Revista Brasileira de Enfermagem
Sun Young Choi, Ji Yeon Hong, Eun Jung Ko, Beom Joon Kim, Sung-Woon Hong, Mi Hyoung Lim, Sung Hum Yeon, Rak Ho Son
BACKGROUND: Oxidative stress and photodamage resulting from ultraviolet radiation exposure play key roles in skin aging. Fermented Cyclopia intermedia, which is used to brew honeybush tea, exerts antioxidant and anti-wrinkle effects by inhibiting reactive oxygen species production and downregulating matrix metalloproteinase activity. OBJECTIVES: This randomized, double-blinded, placebo-controlled study aimed to evaluate the efficacy and safety of fermented honeybush (Cyclopia intermedia) extract (HU-018) for skin rejuvenation...
February 1, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
Lindsay M Yuh, Primo N Lara, Rebecca M Wagenaar, Christopher P Evans, Marc A Dall'era, Rosemary Cress, Stanley A Yap
INTRODUCTION: We aimed to characterize demographic distribution, patient outcomes, and prognostic features of testicular sex cord stromal tumours (SCST) using a large statewide database. METHODS: Adult male patients diagnosed with SCST between 1988 and 2010 were identified within the California Cancer Registry (CCR). Baseline demographic variables and disease characteristics were reported. Primary outcome measures were cancer-specific survival (CSS) and overall survival (OS)...
September 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
Philippe Gatault, Sally Al-Hajj, Johan Noble, Eloi Chevallier, Marie Piollet, Catherine Forconi, Catherine Gaudy-Graffin, Gilles Thibault, Elodie Miquelestorena-Standley, Jean Michel Halimi, Matthias Büchler, Roxane Lemoine, Christophe Baron
We aimed to determine the role of cytomegalovirus (CMV)-infected donor cells in the development of a CMV-specific immune response in kidney transplant recipients. We assessed the CMV pp65-specific immune response by using interferon-ɣ ELISPOT and dextramers in peripheral blood mononuclear cells from 115 recipients (D+R- 31, D+R+ 44, D-R+ 40) late after transplantation (mean 59±42 months). Receiving a kidney from a D+ donor resulted in a higher number of IFN-ɣ-producing anti-CMV T-cells (p=0.004). This effect disappeared with the absence of shared HLA class I specificities between donors and recipients (p=0...
January 27, 2018: American Journal of Transplantation
Jinbao He, Cristina Fernández, Ana Primo, Hermenegildo Garcia
MoS₂ is a promising material to replace Pt-based catalysts for the hydrogen evolution reaction (HER), due to its excellent stability and high activity. In this work, MoS₂ nanoparticles supported on graphitic carbon (about 20 nm) with a preferential 002 facet orientation have been prepared by pyrolysis of alginic acid films on quartz containing adsorbed (NH₄)₂MoS₄ at 900 °C under Ar atmosphere. Although some variation of the electrocatalytic activity has been observed from batch to batch, the MoS₂ sample exhibited activity for HER (a potential onset between 0...
January 22, 2018: Materials
Laura di Blasio, Alberto Puliafito, Paolo Armando Gagliardi, Valentina Comunanza, Desiana Somale, Giulia Chiaverina, Federico Bussolino, Luca Primo
Somatic activating mutations within the PIK3CA gene have been recently detected in sporadic lymphatic and venous malformations, and in vascular malformations (VM) associated to overgrowth syndromes, such as CLOVES and Klippel-Trenaunay syndrome. Although VM are often limited to specific tissue areas and can be well treated, in extended or recurrent lesions novel therapeutic approaches are needed. We generated a mouse model of VM by local expression of PIK3CA-activating mutation in endothelial cells. PIK3CA-driven lesions are characterized by large areas of hemorrhage, hyperplastic vessels, infiltrates of inflammatory cells, and elevated endothelial cell density...
January 19, 2018: Cell Death & Disease
Gianluca Montanari Vergallo, Simona Zaami, Natale Mario Di Luca, Giuseppe Bersani, Raffaella Rinaldi
RIASSUNTO. Da anni gli psichiatri vivono in maniera pressante il rischio di essere sottoposti a processo penale per responsabilità professionale. Una delle ragioni di questa situazione sta nel fatto che il professionista non può contare su regole di comportamento chiare. Anzi, proprio in psichiatria è possibile che un giudice consideri colposa una condotta che per un altro Tribunale non è sanzionabile, come nei casi di dimissioni ospedaliere. Per rimediare a questa situazione il legislatore italiano ha emanato la legge 8 marzo 2017, n...
November 2017: Rivista di Psichiatria
Daniel Antonio de Luis, Enrique Romero, Olatz Izaola, David Primo, Rocío Aller
BACKGROUND: The role of brain-derived neurotrophic factor (BDNF) variants on change in body weight and cardiovascular risk factors after weight loss remains unclear in obese patients. OBJECTIVE: Our aim was to analyze the effects of the rs10767664 BDNF gene polymorphism on body weight, cardiovascular risk factors, and serum adipokine levels after a high monounsaturated fatty acids (MUFAs) hypocaloric diet (diet M) versus a high polyunsaturated fatty acids (PUFAs) hypocaloric diet (diet P)...
January 17, 2018: Journal of Nutrigenetics and Nutrigenomics
Daniel Antonio de Luis, Olatz Izaola, David Primo, R Aller, A Ortola, E Gómez, J J Lopez
BACKGROUND: Several adiponectin gene (ADIPOQ) single nucleotide polymorphisms (SNPS) have been related with adiponectin levels and risk for obesity. OBJECTIVE: The aim of our study was to analyze the effect of rs1501299 ADIPOQ gene polymorphism and dietary intake on total adiponectin levels and insulin resistance after two hypocaloric diets in obese subjects. MATERIAL AND METHODS: A Caucasian population of 284 obese patients was enrolled in a randomized clinical trial with two hypocaloric diets (I: moderate carbohydrates vs II: low fat)...
January 8, 2018: Diabetes Research and Clinical Practice
David Bajnai, Jens Fiebig, Adam Tomašových, Sara Milner Garcia, Claire Rollion-Bard, Jacek Raddatz, Niklas Löffler, Cristina Primo-Ramos, Uwe Brand
Brachiopod shells are the most widely used geological archive for the reconstruction of the temperature and the oxygen isotope composition of Phanerozoic seawater. However, it is not conclusive whether brachiopods precipitate their shells in thermodynamic equilibrium. In this study, we investigated the potential impact of kinetic controls on the isotope composition of modern brachiopods by measuring the oxygen and clumped isotope compositions of their shells. Our results show that clumped and oxygen isotope compositions depart from thermodynamic equilibrium due to growth rate-induced kinetic effects...
January 11, 2018: Scientific Reports
Thais Rodrigues Campos Soares, Luciana Pereira da Silva, Patrícia de Andrade Risso, Lucianne Cople Maia, Laura Guimarães Primo
This is a case report on the management of a vital lateral incisor with a radiolucent cervical area associated with the presence of necrotic pulp due to a dens invaginatus (DI) type III. A nine-year-old boy presented to a university pediatric dental clinic with dental trauma. The examination showed poor oral hygiene, an uncomplicated fracture in the permanent maxillary left central incisor, and a fistula near the permanent maxillary right lateral incisor. A radiograph showed that the right lateral incisor had incomplete root development and a type III DI...
September 15, 2017: Journal of Dentistry for Children
Clarissa Lopes Drumond, Ednele Primo Miranda, Débora Souto Souza, Leandro Silva Marques, Maria Letícia Ramos-Jorge, Joana Ramos-Jorge
PURPOSE: The purpose of this study was to evaluate associations between traumatic dental injury (TDI) and maternal stress and demographic, behavioral, and clinical characteristics of schoolchildren. METHODS: A cross-sectional investigation was conducted involving 396 eight- to 11- year-old schoolchildren in the city of Diamantina, Minas Gerais, Brazil. Maternal stress and demographic and behavioral (breastfeeding and non-nutritive sucking habits) factors were evaluated using a questionnaire...
September 15, 2017: Journal of Dentistry for Children
Daniel Antonio De Luis, Olatz Izaola, David Primo, Susana García Calvo, Emilia Gómez Hoyos, Juan José López Gómez, Ana Ortola, Cristina Serrano, Esther Delgado, Beatriz Torres Torres
BACKGROUND: There is few evidence of cholesterol ester transfer protein (CETP) in subjects with obesity and diabetes mellitus. OBJECTIVES: We examined the association of the polymorphism (rs1800777) of CETP gene on anthropometric parameters, lipid profile and adipokines in subjects with obesity and diabetes mellitus type 2. MATERIAL AND METHODS: A population of 229 obese subjects with diabetes mellitus type 2 was enrolled. An electrical bioimpedance, blood pressure, dietary intake, exercise and biochemical analyses were recorded...
November 14, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Daniel Antonio de Luis, Olatz Izaola, David Primo, Rocio Aller
BACKGROUND & AIMS: A G-to-A transition located 75 base pairs upstream (rs670) from transcription start site of the APOA1 gene is related with metabolic parameters. The aim of the present investigation was to describe the association of rs670 with metabolic syndrome and metabolic parameters. METHODS: The study involved a population of 1000 obese subjects. Measurements of anthropometric parameters, arterial blood pressure, fasting blood glucose, C-reactive protein (CRP), insulin concentration, insulin resistance (HOMA-IR), lipid profile, adipokines levels and prevalence of MetS was recorded...
December 15, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
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