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Dong Lin, Xiaozhen Huang, Wanyu Zhuang, Lili Lin
Through the systematic analysis on the primo vascular system (PVS) in recent years, we believe that in recent years, more and more studies have indicated that PVS is distributed in reticulate structure in every part of body, such as vessels, lymphangions, nerves, brain, spinal cords and internal organs, and it contains a large amount of immunocytes and has involved in the physiological or pathological process of the immunity and circulation in the body. There are the evidences to prove that in morphology and cytobiology...
January 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
Agostino Leone, Ilenia Urso, Dimitrios Damalas, Jann Martinsohn, Antonella Zanzi, Stefano Mariani, Emilio Sperone, Primo Micarelli, Fulvio Garibaldi, Persefoni Megalofonou, Luca Bargelloni, Rafaella Franch, David Macias, Paulo Prodöhl, Séan Fitzpatrick, Marco Stagioni, Fausto Tinti, Alessia Cariani
Background: The blue shark (Prionace glauca, Linnaeus 1758) is one of the most abundant epipelagic shark inhabiting all the oceans except the poles, including the Mediterranean Sea, but its genetic structure has not been confirmed at basin and interoceanic distances. Past tagging programs in the Atlantic Ocean failed to find evidence of migration of blue sharks between the Mediterranean and the adjacent Atlantic, despite the extreme vagility of the species. Although the high rate of by-catch in the Mediterranean basin, to date no genetic study on Mediterranean blue shark was carried out, which constitutes a significant knowledge gap, considering that this population is classified as "Critically Endangered", unlike its open-ocean counterpart...
2017: PeerJ
Christophe J Queval, Roland Brosch, Roxane Simeone
Mycobacterium tuberculosis (Mtb), the etiological agent of human tuberculosis (TB), has plagued humans for thousands of years. TB still remains a major public health problem in our era, causing more than 4,400 deaths worldwide every day and killing more people than HIV. After inhaling Mtb-contaminated aerosols, TB primo-infection starts in the terminal lung airways, where Mtb is taken up by alveolar macrophages. Although macrophages are known as professional killers for pathogens, Mtb has adopted remarkable strategies to circumvent host defenses, building suitable conditions to survive and proliferate...
2017: Frontiers in Microbiology
Cindy Park-Windhol, Yin Shan Ng, Jinling Yang, Vincent Primo, Magali Saint-Geniez, Patricia A D'Amore
Angiogenesis is central to both normal and pathologic processes. Endothelial cells (ECs) express O-glycoproteins that are believed to play important roles in vascular development and stability. Endomucin-1 (EMCN) is a type I O-glycosylated, sialic-rich glycoprotein, specifically expressed by venous and capillary endothelium. Evidence has pointed to a potential role for EMCN in angiogenesis but it had not been directly investigated. In this study, we examined the role of EMCN in angiogenesis by modulating EMCN levels both in vivo and in vitro...
December 7, 2017: Scientific Reports
Sophie Novelli, Camille Lécuroux, Véronique Avettand-Fenoel, Rémonie Seng, Asma Essat, Philippe Morlat, Jean-Paul Viard, Christine Rouzioux, Laurence Meyer, Cécile Goujard
Background: We aimed to determine the consequences of delayed HIV-1 infection diagnosis by comparing long-term outcomes depending on the time of combination antiretroviral therapy (cART) initiation in patients diagnosed during primary HIV infection (PHI). Methods: We selected patients from the ANRS PRIMO cohort, treated for ≥36 months, with sustained HIV-RNA< 50 copies/mL: 77 treated within one month following PHI diagnosis (immediate ART) and 73 treated >12 months after infection (deferred ART)...
December 2, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Daniel Antonio de Luis, Olatz Izaola, David Primo, R Aller
BACKGROUND & AIMS: Omentin-1 might play a role on insulin resistance, dyslipidemia and obesity. The aim of this investigation was to evaluate the influence of weight loss on omentin-1 concentrations after a hypocaloric diet with Mediterranean pattern. METHODS: A Caucasian sample of 67 obese patients was analyzed before and after 3 months on a hypocaloric diet. Anthropometric parameters, blood pressure, fasting blood glucose, C-reactive protein (CRP), fasting insulin, insulin resistance (HOMA-IR), lipid concentrations and omentin-1 were measured...
November 21, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
María Magán-Maganto, Álvaro Bejarano-Martín, Clara Fernández-Alvarez, Antonio Narzisi, Patricia García-Primo, Rafal Kawa, Manuel Posada, Ricardo Canal-Bedia
Over the last several years there has been an increasing focus on early detection of Autism Spectrum Disorder (ASD), not only from the scientific field but also from professional associations and public health systems all across Europe. Not surprisingly, in order to offer better services and quality of life for both children with ASD and their families, different screening procedures and tools have been developed for early assessment and intervention. However, current evidence is needed for healthcare providers and policy makers to be able to implement specific measures and increase autism awareness in European communities...
December 1, 2017: Brain Sciences
J L J Hanssen, N M Delfos
We present a 36-year-old woman who was born and raised in Hongkong but currently lived in the Netherlands. She was admitted with a varicella-zoster virus (VZV) primo-infection complicated by pneumonia and hepatitis. The patient was successfully treated with aciclovir. Adult VZV primo-infections are uncommon in Dutch natives but occur more often in immigrants from countries with a temperate climate where less people are infected during childhood.
2017: Nederlands Tijdschrift Voor Geneeskunde
Joshua D Lara, Ann Brunson, Jonathan W Riess, Karen Kelly, Primo N Lara, David R Gandara
BACKGROUND: Small cell lung cancer (SCLC) is an often lethal disease that commonly occurs in older individuals with a history of heavy tobacco use. Limited epidemiologic and outcomes data are available on young SCLC patients aged less than 50 years of age. We assessed clinical variables related to cause specific survival (CSS) of young patients with SCLC. METHODS: SCLC patients in the California Cancer Registry diagnosed between 1998 and 2012 were included. Primary outcome measure was CSS...
October 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Carmelo Di Primo, Jean-Luc Taupin, Jonathan Visentin
No abstract text is available yet for this article.
November 21, 2017: Human Immunology
Daniel Antonio de Luis, H Fernández Ovalle, O Izaola, D Primo, Rocío Aller
BACKGROUND: Role of BDNF variants on change in body weight and cardiovascular risk factors after weight loss remains unclear in obese patients. OBJECTIVE: Our aim was to analyze the effects of rs10767664 BDNF gene polymorphism on body weight, cardiovascular risk factors and serum adipokine levels after a standard hypocaloric diet in obese subjects. DESIGN: A Caucasian population of 80 obese patients was analyzed before and after 3months on a standard hypocaloric diet...
October 14, 2017: Journal of Diabetes and its Complications
Paolo Armando Gagliardi, Desiana Somale, Alberto Puliafito, Giulia Chiaverina, Laura di Blasio, Michele Oneto, Paolo Bianchini, Federico Bussolino, Luca Primo
Extrusion of apoptotic cells from epithelial tissues requires orchestrated morphological rearrangements of the apoptotic cell and its neighbors. However, the connections between the apoptotic cascade and events leading to extrusion are not fully understood. Here, we characterize an apoptotic extrusion apical actin ring (EAAR) that is assembled within the apoptotic cell and drives epithelial extrusion. Caspase-mediated cleavage of myotonic dystrophy kinase-related CDC42-binding kinase-α (MRCKα) triggers a signaling pathway that leads to the assembly of EAAR that pulls actin bundles, resulting in the compaction and removal of the cell body...
November 21, 2017: Journal of Cell Biology
Cândida Caniçali Primo, Marcos Antônio Gomes Brandão
OBJECTIVE: To describe a breastfeeding theory based on King's Conceptual System. METHOD: Theoretical study that used analysis of concept, assertion synthesis, and derivation of theory for the creation of a new theory. RESULTS: King's system components were associated with elements of the breastfeeding process and a middle-range theory was created, which describes, explains, predicts, and prescribes breastfeeding by analyzing factors that precede and affect it, as well as their consequences on the breastfeeding process...
November 2017: Revista Brasileira de Enfermagem
Daniel Antonio de Luis, Olatz Izaola, David Primo, Rocio Aller
BACKGROUND/AIM: Several adiponectin gene (ADIPOQ) single nucleotide polymorphisms (SNPS) have been related with adiponectin levels and risk for obesity. Our aim was to analyze the effects of rs1501299 ADIPOQ gene polymorphism on total adiponectin levels, insulin resistance and weight loss after a Mediterranean hypocaloric diet in obese subjects. METHODS: A Caucasian population of 82 obese patients was analyzed, before and after 3 months on a Mediterranean hypocaloric diet...
November 14, 2017: Diabetes Research and Clinical Practice
Mamta Parikh, Primo N Lara
In the last 30 years, there have been many advances in the treatment of metastatic renal cell carcinoma of the clear cell type. Renal cell carcinoma has long been understood to have a component of immune mediation and has been responsive to immune-based therapies; in addition to early cytokine therapy, newer checkpoint inhibition therapies have also demonstrated activity. Molecular characterization of the genome of clear cell renal cell carcinoma enabled identification of the roles of angiogenesis and hypoxic stress...
November 16, 2017: Annual Review of Medicine
Emanuele Frontoni, Rama Pollini, Paola Russo, Primo Zingaretti, Graziano Cerri
The aim of this paper is to present the main results of HDOMO, an Ambient Assisted Living (AAL) project that involved 16 Small and Medium Enterprises (SMEs) and 2 research institutes. The objective of the project was to create an autonomous and automated domestic environment, primarily for elderly people and people with physical and motor disabilities. A known and familiar environment should help users in their daily activities and it should act as a virtual caregiver by calling, if necessary, relief efforts...
November 13, 2017: Sensors
Daniel Antonio de Luis, Olatz Izaola, David Primo, Hilda F Ovalle, Juan Jose Lopez, Emilia Gomez, Ana Ortola, Rocio Aller
BACKGROUND/AIMS: The aim of our study was to evaluate the influence of lifestyle factors and molecular biomarkers on the maintenance of the weight lost after a hypocaloric Mediterranean diet. DESIGN: After 3 months on a diet, patients (n = 335) remained with no controlled diet during 3 years and they were revaluated. RESULTS: Using linear regression, in the group of responders, we detected that a positive weight loss at 3 months, serum levels of leptin at 3 months, and each 30 min per week of physical activity were associated with weight loss maintenance...
November 14, 2017: Annals of Nutrition & Metabolism
Marina Lermenn Vidal, Guilherme Ferreira Rego, Gil Mendes Viana, Lucio Mendes Cabral, Juliana Primo Basílio Souza, Nick Silikas, Luis Felipe Schneider, Larissa Maria Cavalcante
OBJECTIVE: Investigate physical and chemical properties of model composites formulated with quaternary ammonium salt monomers (QAS) at different concentrations and alkyl chains lengths METHODS: QAS with 12 dimethylaminododecyl methacrylate (DMADDM) and 16 dimethylaminohexadecyl methacrylate (DMAHDM) chains lengths were synthesized and incorporated at 5 and 10% in model composites, resulting in four groups: G12.5 (DMADDM 5%), G12.10 (DMADDM 10%), G16.5 (DMAHDM 5%), G16.10 (DMAHDM 10%)...
November 10, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
Emiliano D Primo, Lisandro H Otero, Francisco Ruiz, Sebastián Klinke, Walter Giordano
The bacterial cell wall, a structural unit of peptidoglycan polymer comprised of glycan strands consisting of a repeating disaccharide motif [N-acetylglucosamine (NAG) and N-acetylmuramylpentapeptide (NAM pentapeptide)], encases bacteria and provides structural integrity and protection. Lysozymes are enzymes that break down the bacterial cell wall and disrupt the bacterial life cycle by cleaving the linkage between the NAG and NAM carbohydrates. Lab exercises focused on the effects of lysozyme on the bacterial cell wall are frequently incorporated in biochemistry classes designed for undergraduate students in diverse fields as biology, microbiology, chemistry, agronomy, medicine, and veterinary medicine...
November 13, 2017: Biochemistry and Molecular Biology Education
Daniel Antonio De Luis Román, David Primo
No abstract text is available yet for this article.
October 24, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
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