Read by QxMD icon Read


Beom K Choi, Sun H Hwang, Yu I Kim, Rohit Singh, Byoung S Kwon
The Hyaluronic Acid-rich Node and Duct System (HAR-NDS or NDS), Primo Vascular System (PVS) or Bonghan System (BHS), is thought to be a third circulatory system independent of the blood and lymphatic systems and a structure of connected nodes and ducts. Although it seems to be part of the immune system as it is enriched with cells of innate immunity, little is known about its immunological roles. We performed cellular profiling and secretome analysis of NDS in a steady state and under TLR2- or TLR4-mediated local inflammation, and found that the NDS is pre-dominantly enriched with the myeloid cells, selectively attracts the inflammatory macrophages and neutrophils, has a flexible structure just like the lymph node, and is structured with the fibroblastic reticular cells and reticular network...
June 12, 2018: Cytokine
Jonathan Visentin, Lionel Couzi, Claire Dromer, Martine Neau-Cransac, Gwendaline Guidicelli, Vincent Veniard, Karine Nubret-le Coniat, Pierre Merville, Carmelo Di Primo, Jean-Luc Taupin
Human leukocyte antigen (HLA) donor-specific antibodies are key serum biomarkers for assessing the outcome of transplanted patients. Measuring their active concentration, i.e. the fraction that really interacts with donor HLA, and their affinity could help deciphering their pathogenicity. Surface plasmon resonance (SPR) is recognized as the gold-standard for measuring binding kinetics but also active concentrations, without calibration curves. SPR-based biosensors often suffer from non-specific binding (NSB) occurring with the sensor chip surface and the immobilized targets, especially for complex media such as human serum...
June 7, 2018: Biosensors & Bioelectronics
David R Gandara, Jonathan W Riess, Primo N Lara
No abstract text is available yet for this article.
June 14, 2018: JAMA Oncology
Daniel Primo, Lydia Scarfò, Aliki Xochelli, Mattias Mattsson, Pamela Ranghetti, Ana Belén Espinosa, Alicia Robles, Julian Gorrochategui, Joaquín Martínez-López, Javier de la Serna, Marcos González, Alberto Chaparro Gil, Eduardo Anguita, Sandra Iraheta, Veerendra Munugalavadla, Christophe Quéva, Stacey Tannheimer, Richard Rosenquist, Kostas Stamatopoulos, Joan Ballesteros, Paolo Ghia
PI3Kδ (idelalisib) and BTK (ibrutinib) inhibitors have demonstrated significant clinical activity in chronic lymphocytic leukemia (CLL) interfering with the cross-talk between CLL cells and the lymph node microenviroment, yet their mechanism of action remains to be fully elucidated. Here, we developed an ex vivo model with the aim of reproducing the effects of the microenvironment that would help shed light on the in vivo mechanism of action of idelalisib and ibrutinib and predict their clinical efficacy in individual patients...
May 25, 2018: Oncotarget
Sérgio Barra, Jakub Baran, Kumar Narayanan, Serge Boveda, Simon Fynn, Patrick Heck, Andrew Grace, Sharad Agarwal, João Primo, Eloi Marijon, Rui Providência
BACKGROUND: Maintenance of sinus rhythm has been associated with lower mortality, but whether atrial fibrillation (AF) ablation per se benefits hard outcomes such as mortality and stroke is still debated. OBJECTIVE: To determine whether AF ablation is associated with a reduction in all-cause mortality and stroke compared with medical therapy alone. METHODS: Literature search looking for both randomized and observational studies comparing AF catheter ablation vs...
September 1, 2018: International Journal of Cardiology
Julie Alice Simon, Roger Pradel, Dominique Aubert, Régine Geers, Isabelle Villena, Marie-Lazarine Poulle
BACKGROUND: Domestic cats play a key role in the epidemiology of the parasite Toxoplasma gondii by excreting environmentally-resistant oocysts that may infect humans and other warm-blooded animals. The dynamics of Toxoplasma gondii seroconversion, used as a proxy for primo-infection dynamics, was investigated in five cat populations living on farms. METHODS: Serological tests on blood samples from cats were performed every three months over a period of two years, for a total of 400 serological tests performed on 130 cats...
June 8, 2018: Parasites & Vectors
Natalia Maria Candido, Maryanne Trafani de Melo, Leonardo Pereira Franchi, Fernando Lucas Primo, Antônio Cláudio Tedesco, Paula Rahal, Marília Freitas Calmon
Nanomedical approaches are the major transforming factor in cancer therapies. Based on important previous works in the field of drug delivery nanomaterials, recent years have brought a broad array of new and improved intelligent nanoscale platforms that are suited to deliver drugs. In this context, the purpose of this study was to investigate the action of different nanoemulsions designed to encapsulate chloroaluminum phthalocyanine, a hydrophobic photosensitizer used in photodynamic therapy, and doxorubicin, a well-known chemotherapeutic agent used to treat aggressive breast cancer cells...
May 1, 2018: Journal of Biomedical Nanotechnology
Sharon Jiyoon Jung, Myung Geun Kook, Sungchul Kim, Kyung-Sun Kang, Kwang-Sup Soh
Homing of stem cells (SCs) to desired targets such as injured tissues remains a lingering problem in cell-based therapeutics. Studies on the biodistribution of intravenously administered SCs have shown the inefficacy of blood vessels as the homing path because most of the injected SCs are captured in the capillary beds of the lungs. We considered an alternative administration method utilizing the acupuncture meridians or the primo vascular system (PVS). We injected SCs at the acupoint Zusanli (ST-36) below the knee of a nude mouse with a spinal cord injured at the thoracic T9-10 vertebrae...
June 4, 2018: Journal of Acupuncture and Meridian Studies
Luiz Carlos Zeferino, Joana Bragança Bastos, Diama Bhadra Andrade Peixoto do Vale, Rita Maria Zanine, Yara Lucia Mendes Furtado de Melo, Walquíria Quida Salles Pereira Primo, Flávia de Miranda Corrêa, Isabel Cristina Chulvis do Val, Fábio Russomano
Evidence-based clinical guidelines ensure best practice protocols are available in health care. There is a widespread use of human papillomavirus deoxyribonucleic acid (HPV-DNA) tests in Brazil, regardless of the lack of official guidelines. On behalf of the Brazilian Association for the Lower Genital Tract Pathology and Colposcopy (ABPTGIC, in the Portuguese acronym), a team of reviewers searched for published evidence and developed a set of recommendations for the use of HPV-DNA tests in cervical cancer screening in Brazil...
June 6, 2018: Revista Brasileira de Ginecologia e Obstetrícia
Daniel Antonio de Luis, Olatz Izaola, David Primo, R Aller
OBJECTIVE: The aim of this study was to analyze the effects of rs670 APOA1 gene polymorphism on obesity parameters, lipid profile, glucose metabolism markers, blood pressure and adipokine levels after a hypocaloric diet with Mediterranean pattern. MATERIAL AND METHODS: A population of 82 obese patients was studied before and after 12 weeks on a hypocaloric diet (500 kcal per day) in an interventional study of one arm. GG and GA+AA subjects receiving the same diet...
May 30, 2018: Diabetes Research and Clinical Practice
Itziar Ubillos, Alfons Jiménez, Marta Vidal, Paul W Bowyer, Deepak Gaur, Sheetij Dutta, Benoit Gamain, Ross Coppel, Virander Chauhan, David Lanar, Chetan Chitnis, Evelina Angov, James Beeson, David Cavanagh, Joseph J Campo, Ruth Aguilar, Carlota Dobaño
BACKGROUND: The quantitative suspension array technology (qSAT) is a useful platform for malaria immune marker discovery. However, a major challenge for large sero-epidemiological and malaria vaccine studies is the comparability across laboratories, which requires the access to standardized control reagents for assay optimization, to monitor performance and improve reproducibility. Here, the Plasmodium falciparum antibody reactivities of the newly available WHO reference reagent for anti-malaria human plasma (10/198) and of additional customized positive controls were examined with seven in-house qSAT multiplex assays measuring IgG, IgG1-4 subclasses, IgM and IgE against a panel of 40 antigens...
June 1, 2018: Malaria Journal
Jessica H Williams, Kathryn DeLaughter, Julie E Volkman, Rajani S Sadasivam, Midge N Ray, Gregg H Gilbert, Thomas K Houston
PURPOSE: To describe the content of messages sent by smokers through asynchronous counseling within a Web-based smoking cessation intervention. DESIGN: Qualitative. SETTING: National community-based setting of patients who had been engaged by the medical or dental practices at which they attended or via Google advertisements. PARTICIPANTS: Adults older than 19 years who were current smokers and interested in quitting...
June 2018: American Journal of Health Promotion: AJHP
Simona Mattioli, Joana Margarida Machado Duarte, Cesare Castellini, Roberto D'Amato, Luca Regni, Primo Proietti, Daniela Businelli, Elisa Cotozzolo, Miguel Rodrigues, Alessandro Dal Bosco
Sixty New Zealand White weaned rabbits were divided into three groups and subjected to different dietary treatments: a standard diet for the control (C), a standard feed supplemented with 10% of plain olive leaves (OL) and a standard feed supplemented with 10% of selenium-fortified olive leaves (100 mg/L of foliar spray sodium selenate solution; SeOL). The productive performance was recorded at the time of slaughter (after 35 days); the carcass and meat traits were determined and estimated indexes of fatty acid metabolism were calculated...
May 18, 2018: Meat Science
Jaubert Chloé, Bedrat Amina, Bartolucci Laura, Di Primo Carmelo, Ventura Michel, Mergny Jean-Louis, Amrane Samir, Andreola Marie-Line
DNA and RNA guanine-rich oligonucleotides can form non-canonical structures called G-quadruplexes or "G4" that are based on the stacking of G-quartets. The role of DNA and RNA G4 is documented in eukaryotic cells and in pathogens such as viruses. Yet, G4 have been identified only in a few RNA viruses, including the Flaviviridae family. In this study, we analysed the last 157 nucleotides at the 3'end of the HCV (-) strand. This sequence is known to be the minimal sequence required for an efficient RNA replication...
May 25, 2018: Scientific Reports
Lucas Duarte-Rodrigues, Ednele Fabyene Primo Miranda, Taiane Oliveira Souza, Haroldo Neves de Paiva, Saulo Gabriel Moreira Falci, Endi Lanza Galvão
OBJECTIVE: The purpose of this systematic review was to assess the impact of third molar removal on patient's quality of life. METHODS: To address the study purpose, investigators designed and implemented a systematic review. The primary outcome variable was the quality of life after third molar extraction. An electronic search was conducted through March, 2017, on the PUBMED, Virtual Health Library (VHL), Web of Science, and OVID, to identify relevant literatures...
May 24, 2018: Quality of Life Research
A Fogliata, F De Rose, A Stravato, G Reggiori, S Tomatis, M Scorsetti, L Cozzi
BACKGROUND: Monte Carlo simulations were run to estimate the dose variations generated by thedifference arising from the chemical composition of the tissues. METHODS: CT datasets of five breast cancer patients were selected. Mammary gland was delineated as clinical target volume CTV, as well as CTV_lob and CTV_fat, being the lobular and fat fractions of the entire mammary gland. Patients were planned for volumetric modulated arc therapy technique, optimized in the Varian Eclipse treatment planning system...
May 15, 2018: Radiation Oncology
Alessandro Esposito, Sofia Silva, Jorge Oliveira, Joana Lencart, João Santos
BACKGROUND: IMRT provides higher dose conformation to the target and dose sparing to surrounding tissues than 3DCRT. Monte Carlo method in Medical Physics is not a novelty to approach dosimetric problems. A new PENELOPE based code named PRIMO recently was published. The most intriguing features of PRIMO are the user-friendly approach, the stand-alone property and the built-in definition of different linear accelerators models. Nevertheless, IMRT simulations are not yet implemented. METHODS: A Varian Trilogy with a Millennium120 MLC and a Varian Novalis with 120HD MLC were studied...
May 15, 2018: Radiation Oncology
Fletcher Kovich
This article provides a new definition of an acupuncture meridian. It suggests that a meridian consists of a distal tract of tissue that is affected by organ function. In the 1960's, Kim discovered the primo vascular system, and regarded the superficial primo vessels as equating to the meridians. Instead, this article suggests that the superficial primo vessels merely underlie the meridians, in that they enable their creation, which is why some meridians are said to occur along the paths of superficial primo vessels...
May 11, 2018: Journal of Acupuncture and Meridian Studies
A Jensen, L O Bonde
AIMS: This literature review aims to illustrate the variety and multitude of studies showing that participation in arts activities and clinical arts interventions can be beneficial for citizens with mental and physical health problems. The article is focused on mental health benefits because this is an emerging field in the Nordic countries where evidence is demanded from national health agencies that face an increasing number of citizens with poor mental health and a need for non-medical interventions and programmes...
April 1, 2018: Perspectives in Public Health
Anna Jaros, Malwina Zasada, Elżbieta Budzisz, Renata Dębowska, Monika Gębczyńska-Rzepka, Helena Rotsztejn
BACKGROUND: Ascorbic acid is a substance with confirmed anti-free-radical properties. It triggers the collagen synthesis, has a depigmenting effect and seals blood vessels. All these properties have a significant effect of the skin's appearance. The characteristic traits of capillary skin include telangiectasias as well as erythema, which might consolidate in the future, along with the feeling of burning and increased skin sensitivity. OBJECTIVES: Study and evaluation of selected parameters of capillary skin after the application of 5% vitamin C concentrate throughout the period of 6 weeks with the use of instrumental tests and questionnaires...
April 30, 2018: Journal of Cosmetic Dermatology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"