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https://www.readbyqxmd.com/read/28095761/the-caring-encounter-in-nursing
#1
Gunilla Holopainen, Lisbet Nyström, Anne Kasén
BACKGROUND: The concept 'encounter' occurs in caring literature as a synonym for dialogue and relation describing deeper levels of interaction between patient and nurse. In nursing and caring research, the concept 'caring encounter' is often used without further reflection on the meaning of the concept. Encounters are, however, continuously taking place in the world of caring, which calls for a clarification of the concept. OBJECTIVES: This study is an analysis of the concept of caring encounter in nursing from the patients' and nurses' point of view...
January 1, 2017: Nursing Ethics
https://www.readbyqxmd.com/read/28094433/bmp15-knockout-like-effect-in-familial-premature-ovarian-insufficiency-with-persistent-ovarian-reserve
#2
Anne Mayer, Baptiste Fouquet, Michel Pugeat, Micheline Misrahi
Premature ovarian insufficiency (POI) affects 1-2% of women under 40 years. BMP15 variants have been described in POI. We studied a family with two sisters compound heterozygous for deletions in the BMP15 gene on chromosome Xp11.22 yielding a human "knockout-like" effect: a c.151_152delGA deletion yielded a p.Glu51IlefsTer27 mutation transmitted by the hemizygous father and a c.189_198delAGGGCATTCAinsTG deletion/insertion yielded a p.Glu64AlafsTer12 mutation transmitted by the heterozygous mother. Both deletions resulted in frameshifts with premature stop codons at positions 78 and 76 in the proregion, precluding mature BMP15 production...
January 17, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28064279/the-rs1862513-variant-in-resistin-gene-modified-insulin-resistance-and-insulin-levels-after-weight-loss-secondary-to-hypocaloric-diet
#3
Daniel Antonio de Luis, Olatz Izaola, David Primo, Beatriz de la Fuente, Ines Mulero, Rocío Aller
BACKGROUND/AIMS: Polymorphisms of a single nucleotide in RETN have been associated with indexes of insulin resistance. Our aim was to analyze the effects of the rs1862513 RETN gene polymorphism on insulin resistance, insulin levels, and resistin levels changes after 3 months of a low-fat hypocaloric diet. DESIGN: A Caucasian population of 133 obese patients was analyzed before and after 3 months on a low-fat hypocaloric diet. RESULTS: Fifty-six patients (42...
January 7, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28057398/selenium-speciation-profiles-in-biofortified-sangiovese-wine
#4
Maria Chiara Fontanella, Roberto D'Amato, Luca Regni, Primo Proietti, Gian Maria Beone, Daniela Businelli
Biofortification is an agronomic-based strategy, utilized by farmers, to produce selenium (Se)-enriched food products that may help reduce dietary deficiencies of Se occurring throughout susceptible regions of the world. The foliar exposure route application ensures a high efficiency of Se assimilation by the plant since it does not depend on root-to-shoot translocation. In this study we treated grapevines of Sangiovese variety in the pre-flowering period with sodium selenate (100mg Se L(-1)). Se content was measured in leaves, fruit at harvest time and in wine respectively in treated and not treated samples with ICP-MS...
December 19, 2016: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28048546/su-f-t-367-using-primo-a-penelope-based-software-to-improve-the-small-field-dosimetry-of-linear-accelerators
#5
H Benmakhlouf, L Brualla, P Andreo, J Sempau
PURPOSE: To calculate output correction factors for Varian Clinac 2100iX beams for seven small field detectors and use the values to determine the small field output factors for the linacs at Karolinska university hospital. METHODS: Phase space files (psf) for square fields between 0.25cm and 10cm were calculated using the PENELOPE-based PRIMO software. The linac MC-model was tuned by comparing PRIMO-estimated and experimentally determined depth doses and lateral dose-profiles for 40cmx40cm fields...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045458/bacteria-isolated-from-lung-modulate-asthma-susceptibility-in-mice
#6
Aude Remot, Delphyne Descamps, Marie-Louise Noordine, Abdelhak Boukadiri, Elliot Mathieu, Véronique Robert, Sabine Riffault, Bart Lambrecht, Philippe Langella, Hamida Hammad, Muriel Thomas
Asthma is a chronic, non-curable, multifactorial disease with increasing incidence in industrial countries. This study evaluates the direct contribution of lung microbial components in allergic asthma in mice. Germ-Free and Specific-Pathogen-Free mice display similar susceptibilities to House Dust Mice-induced allergic asthma, indicating that the absence of bacteria confers no protection or increased risk to aeroallergens. In early life, allergic asthma changes the pattern of lung microbiota, and lung bacteria reciprocally modulate aeroallergen responsiveness...
January 3, 2017: ISME Journal
https://www.readbyqxmd.com/read/28040800/identification-introgression-and-validation-of-fruit-volatile-qtls-from-a-red-fruited-wild-tomato-species
#7
José L Rambla, Aurora Medina, Asun Fernández-Del-Carmen, Walter Barrantes, Silvana Grandillo, Maria Cammareri, Gloria López-Casado, Guillermo Rodrigo, Arancha Alonso, Santiago García-Martínez, Jaime Primo, Juan J Ruiz, Rafael Fernández-Muñoz, Antonio J Monforte, Antonio Granell
Volatile organic compounds (VOCs) are major determinants of fruit flavor, a primary objective in tomato breeding. A recombinant inbred line (RIL) population consisting of 169 lines derived from a cross between Solanum lycopersicum and a red-fruited wild tomato species Solanum pimpinellifolium accession (SP) was characterized for VOCs in three different seasons. Correlation and hierarchical cluster analyses were performed on the 52 VOCs identified, providing a tool for the putative assignation of individual compounds to metabolic pathways...
December 30, 2016: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28038979/preclinical-evaluation-of-met-inhibitor-inc-280-with-or-without-the-epidermal-growth-factor-receptor-inhibitor-erlotinib-in-non-small-cell-lung-cancer
#8
Matthew S Lara, William S Holland, Danielle Chinn, Rebekah A Burich, Primo N Lara, David R Gandara, Karen Kelly, Philip C Mack
BACKGROUND: Although the epidermal growth factor receptor (EGFR) inhibitor erlotinib is initially effective in non-small-cell lung cancer (NSCLC) patients with tumors harboring activating mutations of EGFR, most subsequently develop acquired resistance. One recognized resistance mechanism occurs through activation of bypass signaling via the hepatocyte growth factor (HGF)-MET pathway. INC-280 is a small molecule kinase inhibitor of MET. We sought to demonstrate the activity of INC-280 on select NSCLC cell lines both as a single agent and in combination with erlotinib using exogenous HGF to simulate MET up-regulation...
November 21, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28027029/mechanisms-of-chromosomal-diversification-in-species-of-rineloricaria-actinopterygii-siluriformes-loricariidae
#9
Cleberson C Primo, Larissa Glugoski, Mara C Almeida, Cláudio H Zawadzki, Orlando Moreira-Filho, Marcelo R Vicari, Viviane Nogaroto
Cytogenetic studies in fish of the Rineloricaria genus have already shown a high variation in diploid number (2n). Along with fusion/fission events for 2n alteration, inversions contribute to the diversification of chromosome formulae within this group. The present study assessed different populations/species of the Rineloricaria aiming to describe the karyotype organization of its members and understand the mechanisms that lead to the variation of chromosome numbers. Cytogenetic data showed distinct karyotype organization among Rineloricaria populations/species studied, ranging in diploid number from 46 to 64 chromosomes, syntopic species and two karyomorphs in Rineloricaria pentamaculata...
December 27, 2016: Zebrafish
https://www.readbyqxmd.com/read/28013245/european-studies-on-prevalence-and-risk-of-autism-spectrum-disorders-according-to-immigrant-status-a-review
#10
Rafał Kawa, Evald Saemundsen, Sigrídur Lóa Jónsdóttir, Annika Hellendoorn, Sanne Lemcke, Ricardo Canal-Bedia, Patricia García-Primo, Irma Moilanen
BACKGROUND: Autism spectrum disorders (ASDs), once considered to be rare, are now reaching prevalence estimates of 1% and higher. Studies conducted in North America indicate large racial/ethnic disparities in the diagnosis of ASDs. Others show, that immigrant children have similar prevalence rates of ASDs as native children, although they are diagnosed later compared with native children. In relation to a EU funded network action, Enhancing the Scientific Study of Early Autism, it was considered important to review the literature on this subject...
December 24, 2016: European Journal of Public Health
https://www.readbyqxmd.com/read/28010831/technical-challenges-in-current-primo-vascular-system-research-and-potential-solutions
#11
REVIEW
Kyung A Kang, Claudio Maldonado, Vitaly Vodyanoy
Since Bonghan Kim's discovery of the Bonghan system (BHS) in the 1960s, numerous reports have suggested that the system is fundamental for maintaining mammalian life. The BHS is a circulatory system independent of the blood or the lymphatic system, forms an extensive network throughout the entire mammalian body, has been reported to be the acupuncture meridian, stores distinct types of stem cells, and appears to have some roles in cancer metastasis. Despite Kim's first report having been published as early as 1962, research progress has been rather slow mainly because the system is very small and translucent, making it optically difficult to distinguish it from the hemoglobin-rich surrounding tissues...
December 2016: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/27997186/graphenes-as-metal-free-catalysts-with-engineered-active-sites
#12
Ana Primo, Vasile Parvulescu, Hermenegildo Garcia
This Perspective article highlights how recent discoveries on the activity of defective graphene to promote different organic reactions as metal-free catalysts has led to propose certain substructures present on these defective graphenes as active sites. The sustainability of using as catalysts graphenes obtained from biomass and the possibility to generate active sites by introducing defects on the sheet are the two main characteristics triggering research in this area. Emphasis is made in the need to gain understanding on the nature of the active sites and how this understanding requires the combination of conventional kinetic experiments as well as advanced characterization tools...
December 20, 2016: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/27983833/identification-of-the-male-produced-aggregation-pheromone-of-the-four-spotted-coconut-weevil-diocalandra-frumenti
#13
Sandra Vacas, Ismael Navarro, Elena Seris, Carina Ramos, Estrella Hernández, Vicente Navarro-Llopis, Jaime Primo
The four-spotted coconut weevil, Diocalandra frumenti Fabricius (Coleoptera: Dryophthoridae), is a small weevil found attacking economically important palm species, such as coconut, date, oil, and Canary palms. Given the scarcity of detection and management tools for this pest, the availability of a pheromone to be included in trapping protocols would be a crucial advantage. Previous laboratory experiments showed evidence for aggregation behavior; thus, our main goal was to identify the aggregation pheromone in this species...
January 18, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27960429/oriented-pt-nanoparticles-supported-on-few-layers-graphene-as-highly-active-catalyst-for-aqueous-phase-reforming-of-ethylene-glycol
#14
Iván Esteve-Adell, Nadia Bakker, Ana Primo, Emiel Hensen, Hermenegildo García
Pt nanoparticles (NPs) strongly grafted on few-layers graphene (G) have been prepared by pyrolysis under inert atmosphere at 900 °C of chitosan films (70-120 nm thickness) containing adsorbed H2PtCl6. Preferential orientation of exposed Pt facets was assessed by X-ray diffraction of films having high Pt loading where the 111 and 222 diffraction lines were observed and also by SEM imaging comparing elemental Pt mapping with the image of the 111 oriented particles. Characterization techniques allow determination of the Pt content (from 45 ng to 1 μg cm(-2), depending on the preparation conditions), particle size distribution (9 ± 2 nm), and thickness of the films (12-20 nm)...
December 14, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27919627/randomized-phase-2-trial-of-pharmacodynamic-separation-of-pemetrexed-and-intercalated-erlotinib-versus-pemetrexed-alone-for-advanced-nonsquamous-non-small-cell-lung-cancer
#15
Tianhong Li, Bilal Piperdi, William V Walsh, Mimi Kim, Laurel A Beckett, Rasim Gucalp, Missak Haigentz, Venu G Bathini, Huiyu Wen, Kaili Zhou, Patricia B Pasquinelli, Srikanth Gajavelli, Meera Sreedhara, Xianhong Xie, Primo N Lara, David R Gandara, Roman Perez-Soler
BACKGROUND: Pharmacodynamic separation of pemetrexed and erlotinib avoids negative cellular interactions and results in antitumor synergy in erlotinib-resistant non-small-cell lung cancer (NSCLC) cells, independent of EGFR (epidermal growth factor receptor) genotype. PATIENTS AND METHODS: Patients with platinum-treated metastatic nonsquamous NSCLC were randomly assigned 1:2 to pemetrexed alone (500 mg/m(2) provided intravenously on day 1) or pemetrexed followed by erlotinib (150 mg provided orally once daily on days 2-17) every 21 days...
October 28, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/27916243/safe-reentry-for-false-aneurysm-operations-in-high-risk-patients
#16
Gian Luca Martinelli, Attilio Cotroneo, Philippe Primo Caimmi, Gabriele Musica, David Barillà, Edmond Stelian, Angelo Romano, Eugenio Novelli, Luca Renzi, Marco Diena
BACKGROUND: In the absence of a standardized safe surgical reentry strategy for high-risk patients with large or anterior postoperative aortic false aneurysm (PAFA), we aimed to describe an effective and safe approach for such patients. METHODS: We prospectively analyzed patients treated for PAFA between 2006 and 2015. According to the preoperative computed tomography scan examination, patients were divided into two groups according to the anatomy and extension of PAFA: in group A, high-risk PAFA (diameter ≥3 cm) developed in the anterior mediastinum; in group B, low-risk PAFA (diameter <3 cm) was situated posteriorly...
December 1, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27915341/rs1501299-polymorphism-in-the-adiponectin-gene-and-their-association-with-total-adiponectin-levels-insulin-resistance-and-metabolic-syndrome-in-obese-subjects
#17
Daniel Antonio de Luis, Olatz Izaola, Beatriz de la Fuente, David Primo, Hilda Fernandez Ovalle, Enrique Romero
BACKGROUND AND AIMS: The aim of this study was to determine the association of single nucleotide polymorphism rs1501299 in the ADIPOQ gene with body weight, insulin resistance, serum adipokine levels and metabolic syndrome (MetS). METHODS: The study involved a population of 1,007 adult obese subjects. Parameters like body weight, fat mass, waist circumferences, blood pressure, fasting blood glucose, C-reactive protein, insulin concentration, homeostasis model assessment for insulin resistance (HOMA-IR), lipid profile and adipocytokines levels (leptin, adiponectin and resistin) were all measured...
December 3, 2016: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/27911041/impact-of-rabies-vaccination-history-on-attainment-of-an-adequate-antibody-titre-among-dogs-tested-for-international-travel-certification-israel-2010-2014
#18
B Yakobson, N Taylor, N Dveres, S Rotblat, Ż Spero, E W Lankau, J Maki
Rabies is endemic in wildlife or domestic carnivore populations globally. Infection of domestic dogs is of particular concern in many areas. In regions where domestic animals are at risk of exposure to rabies virus, dogs should be routinely vaccinated against rabies to protect both pet and human populations. Many countries require demonstration of an adequate level of serum rabies neutralizing antibodies to permit entry of dogs during international travel. We analysed rabies titres of dogs seeking travel certification in Israel to assess demographic and vaccine history factors associated with antibody titres below the acceptable threshold for travel certification...
December 2, 2016: Zoonoses and Public Health
https://www.readbyqxmd.com/read/27895122/reciprocal-regulation-of-target-of-rapamycin-complex-1-and-potassium-accumulation
#19
Cecilia Primo, Alba Ferri-Blázquez, Robbie Loewith, Lynne Yenush
The proper maintenance of potassium homeostasis is crucial for cell viability. Among the major determinants of potassium uptake in the model organism Saccharomyces cerevisiae are the Trk1 high affinity potassium transporter and the functionally redundant Hal4 (Sat4) and Hal5 protein kinases. These kinases are required for the plasma membrane accumulation of not only Trk1, but also several nutrient permeases. Here, we show that overexpression of the Target of Rapamycin Complex 1 (TORC1) effector NPR1 improves hal4 hal5 growth defects by stabilizing nutrient permeases at the plasma membrane...
November 28, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27867002/trametinib-plus-4-methylumbelliferone-exhibits-antitumor-effects-by-erk-blockade-and-cd44-downregulation-and-affects-pd1-and-pd-l1-in-malignant-pleural-mesothelioma
#20
Hiroyuki Cho, Seiji Matsumoto, Yoshiko Fujita, Ayumi Kuroda, Toshi Menju, Makoto Sonobe, Nobuyuki Kondo, Ikuko Torii, Takashi Nakano, Primo N Lara, David R Gandara, Hiroshi Date, Seiki Hasegawa
INTRODUCTION: Malignant pleural mesothelioma (MPM) is a highly aggressive malignancy in which the mitogen-activated protein kinase (MAPK) pathway plays a critical role in the regulation of tumorigenesis. Hyaluronan (HA) is a major component of the extracellular matrix, and elevated HA levels, with a concurrent increase in malignant properties, are associated with MPM. METHODS: We evaluated the effects of trametinib, a MAPK kinase enzyme (MEK) inhibitor, and 4-methylumbelliferone (4-MU), an HA synthesis inhibitor, alone and in combination on MPM cells in vitro and in vivo...
November 17, 2016: Journal of Thoracic Oncology
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