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Liver biliary tree and pancreas

Francesco D'Amico, Michele Finotti, Chiara Di Renzo, Alessio Pasquale, Alessandra Bertacco, Giorgio Caturegli, Gabriel E Gondolesi, Umberto Cillo
Pancreatic intraductal papillary-mucinous neoplasm is a rare primary neoplasm of unknown pathogenesis. This kind of tumor represents 0.2-2.7% of all pancreatic cancers and they may proceed to malignant lesions. In this study, we describe a case of pancreatic intraductal papillary-mucinous tumor (4.3 cm) with normal tumoral markers and nuclear atypia. We perform also a systematic review of the literature on MEDLINE and find only one relevant study that used microwave ablation for the palliative treatment of pancreatic tumor...
2018: Case Reports in Gastrointestinal Medicine
Alexandros Stamatopoulos, Davide Patrini, Efstratios Koletsis, Elaine Borg, Reena Khiroya, Martin Hayward, David Lawrence, Nikolaos Panagiotopoulos
IgG4-related disease (IgG4-RD) is a fibroinflammatory condition that can affect practically every organ. Although it was first identified in pancreas and salivary glands, major organs like liver, biliary tree, kidney, thyroid glands and lungs are commonly involved, sometimes resulting in organ failure. We describe a case of an 41-year-old man presented with back pain after a rotator cuff injury. A Computed Tomography (CT) revealed incidentally a right lower lobe paravertebral lesion extending across the T5 and T6 vertebral levels and invading into the adjacent pleural surface...
2016: Respiratory Medicine Case Reports
Raza Sayyed, Iffat Rehman, Imran Khalid Niazi, Muhammed Aasim Yusuf, Aamir Ali Syed, Faisal V
Aberrant hepatic arterial anatomy poses a challenge for the surgeon during Whipple procedure. Intraoperative injury to the aberrant vasculature results in hemorrhagic or ischemic complications involving the liver and biliary tree. We report a case of replaced right hepatic artery arising from the superior mesenteric artery in a patient with periampullary carcinoma of the pancreas, undergoing pancreaticoduodenectomy. The aberrant artery was found to be coursing through the pancreatic parenchyma. This is a rare vascular anomaly...
June 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Lola M Reid
No abstract text is available yet for this article.
July 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Kelly J Norsworthy, Bhavana Bhatnagar, Zeba N Singh, Ivana Gojo
Myeloid sarcoma (MS) is a rare extramedullary presentation of myeloid malignancies, most commonly seen in association with acute myeloid leukemia (AML). Although MS can develop in any organ, the involvement of the hepatobiliary system is rare. With clinical manifestations of jaundice, abdominal pain and other gastrointestinal symptoms, MS presenting at this location can be a challenge to diagnose, particularly in patients with no known history of hematologic malignancy. This may cause delay in proper management...
2016: Acta Haematologica
Osama S Al Beteddini, Nasir K Amra, Emad Sherkawi
Ciliated foregut cysts are rare anomalies arising from remnants of aberrant embryological development. Around 100 reports on the presence of these congenital masses in the tracheobronchial tree, mediastinum, liver, pancreas and, rarely, the gallbladder have been described. In this article, the case of a 33-year-old woman, who was operated for a laparoscopic cholecystectomy, is presented. During the dissection of the triangle of Calot, a cystic mass, attached to the common hepatic duct, was discovered incidentally...
December 2016: Surgical Case Reports
Guido Carpino, Rosa Puca, Vincenzo Cardinale, Anastasia Renzi, Gaia Scafetta, Lorenzo Nevi, Massimo Rossi, Pasquale B Berloco, Stefano Ginanni Corradini, Lola M Reid, Marella Maroder, Eugenio Gaudio, Domenico Alvaro
Peribiliary glands (PBGs) are niches in the biliary tree and containing heterogeneous endodermal stem/progenitors cells that can differentiate, in vitro and in vivo, toward pancreatic islets. The aim of this study was to evaluate, in experimental and human diabetes, proliferation of cells in PBGs and differentiation of the biliary tree stem/progenitor cells (BTSCs) toward insulin-producing cells. Diabetes was generated in mice by intraperitoneal injection of a single dose of 200 mg/kg (N = 12) or 120 mg/kg (N = 12) of streptozotocin...
May 2016: Stem Cells
Giacomo Lanzoni, Vincenzo Cardinale, Guido Carpino
UNLABELLED: Stem/progenitors for liver, biliary tree, and pancreas exist at early stages of development in the definitive ventral endoderm forming the foregut. In humans, they persist postnatally as part of a network, with evidence supporting their contributions to hepatic and pancreatic organogenesis throughout life. Multiple stem cell niches persist in specific anatomical locations within the human biliary tree and pancreatic ducts. In liver and pancreas, replication of mature parenchymal cells ensures the physiological turnover and the restoration of parenchyma after minor injuries...
July 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Petr Dítě, Jitka Přinosilová, Lenka Dovrtělová, Tomáš Kupka, Hana Nechutová, Bohuslav Kianička, Bohdana Břegová, Lumír Kunovský, Arnošt Martínek, Miroslav Souček
GOAL: Metabolic syndrome and its components play an important part in the development of not only cardiovascular conditions, but also digestive and pancreaticobiliary system diseases. The aim of our study is to present a comprehensive overview of the diseases where metabolic syndrome is an inducing risk factor, or where it affects the course of the disease. RESULTS: Metabolic syndrome is a significant risk factor of induction of gastroesophageal reflux and its complication, which is Barretts esophagus...
September 2015: Vnitr̆ní Lékar̆ství
Tsunekazu Oikawa, Eliane Wauthier, Timothy A Dinh, Sara R Selitsky, Andrea Reyna-Neyra, Guido Carpino, Ronald Levine, Vincenzo Cardinale, David Klimstra, Eugenio Gaudio, Domenico Alvaro, Nancy Carrasco, Praveen Sethupathy, Lola M Reid
The aetiology of human fibrolamellar hepatocellular carcinomas (hFL-HCCs), cancers occurring increasingly in children to young adults, is poorly understood. We present a transplantable tumour line, maintained in immune-compromised mice, and validate it as a bona fide model of hFL-HCCs by multiple methods. RNA-seq analysis confirms the presence of a fusion transcript (DNAJB1-PRKACA) characteristic of hFL-HCC tumours. The hFL-HCC tumour line is highly enriched for cancer stem cells as indicated by limited dilution tumourigenicity assays, spheroid formation and flow cytometry...
October 6, 2015: Nature Communications
Ali Shirafkan Md, Nahal Boroumand Md, Spogmai Komak Md, Andrea Duchini Md, Luca Cicalese Md
INTRODUCTION: Rhabdomyosarcoma (RMS) is a primary malignancy that arises from the embryonic mesenchyme with the potential to differentiate into skeletal muscle. RMS of the biliary tree is extremely rare. We report a case of an undifferentiated pleomorphic RMS involving the liver and pancreas. PRESENTATION OF CASE: A 62 year old Caucasian woman with rapidly growing abdominal mass and a history of endometrial adenocarcinoma underwent laparotomy due to compression symptoms and concerns of malignancy...
2015: International Journal of Surgery Case Reports
Patrick S McGrath, James M Wells
The endoderm germ layer contributes to the respiratory and gastrointestinal (GI) lineages during development, giving rise to an array of specialized epithelial cell types lining organs, including the thyroid, thymus, lungs, liver, biliary system, pancreas, and intestines. This SnapShot timelines and summarizes key stages following gastrulation, including endoderm patterning, organ specification, and organogenesis. A lineage tree of the developing endocrine pancreas is outlined to further illustrate this process...
March 26, 2015: Cell
Pilar Brito-Zerón, Manuel Ramos-Casals, Xavier Bosch, John H Stone
IgG4-related disease (IgG4-RD) is an emerging immune-mediated disease with the capability of involving essentially any organ. The epidemiology of this disease has not been explored in detail. A majority of patients reported in the literature to date are from Japan, but the condition has been described all across the world and there is no strong evidence to suggest a predilection for Asian populations. The mean age at diagnosis is approximately 60 years and there is a decided male predominance for many clinical features, with an overall male:female ratio of 8:3...
December 2014: Autoimmunity Reviews
Massimo Riccio, Gianluca Carnevale, Vincenzo Cardinale, Lara Gibellini, Sara De Biasi, Alessandra Pisciotta, Guido Carpino, Raffaele Gentile, Pasquale B Berloco, Roberto Brunelli, Carlo Bastianelli, Chiara Napoletano, Alfredo Cantafora, Andrea Cossarizza, Eugenio Gaudio, Domenico Alvaro, Anto De Pol
BACKGROUND & AIMS: Human biliary tree stem/progenitor cells (hBTSCs) are multipotent epithelial stem cells, easily obtained from the biliary tree, with the potential for regenerative medicine in liver, biliary tree, and pancreas diseases. Recent reports indicate that human mesenchymal stem cells are able to modulate the T cell immune response. However, no information exists on the capabilities of hBTSCs to control the allogeneic response. The aims of this study were to evaluate FasL expression in hBTSCs, to study the in vitro interaction between hBTSCs and human lymphocytes, and the role of Fas/FasL modulation in inducing T cell apoptosis in hBTSCs/T cell co-cultures...
November 2014: Journal of Hepatology
Byung Chul Kim, Ki Bae Kim, Eui Joong Kim, Soonyoung Park, Dong-Hwa Lee, Eun Bee Kim, Hee Bok Chae, Seon Mee Park
Most infants with repaired gastroschisis develop normally and remain in good health. About 10% of patients with gastroschisis have other malformations. We report a case of choledocholithiasis and intestinal malrotation in an adolescent with repaired gastroschisis. A 17-year-old girl presented with fever, jaundice, and abdominal pain. She had undergone an operation to repair gastroschisis at birth. Physical examination revealed icteric sclera, a tight abdominal wall, and a longitudinal surgical scar at the midline...
March 2014: Clinical Endoscopy
Francesco Tonelli, Francesco Giudici, Gabriella Nesi, Giacomo Batignani, Maria Luisa Brandi
AIM: To describe our patients affected with ectopic biliary tree gastrinoma and review the literature on this topic. METHODS: Between January 1992 and June 2012, 28 patients affected by duodenopancreatic endocrine tumors in multiple endocrine neoplasia type 1 (MEN1) syndrome underwent surgery at our institution. This retrospective review article analyzes our experience regarding seventeen of these patients subjected to duodenopancreatic surgery for Zollinger-Ellison syndrome (ZES)...
December 7, 2013: World Journal of Gastroenterology: WJG
Giacomo Lanzoni, Tsunekazu Oikawa, Yunfang Wang, Cai-Bin Cui, Guido Carpino, Vincenzo Cardinale, David Gerber, Mara Gabriel, Juan Dominguez-Bendala, Mark E Furth, Eugenio Gaudio, Domenico Alvaro, Luca Inverardi, Lola M Reid
Regenerative medicine is transitioning into clinical programs using stem/progenitor cell therapies for repair of damaged organs. We summarize those for liver and pancreas, organs that share endodermal stem cell populations, biliary tree stem cells (hBTSCs), located in peribiliary glands. They are precursors to hepatic stem/progenitors in canals of Hering and to committed progenitors in pancreatic duct glands. They give rise to maturational lineages along a radial axis within bile duct walls and a proximal-to-distal axis starting at the duodenum and ending with mature cells in the liver or pancreas...
October 2013: Stem Cells
Takashi Matsubara, Yasunori Sato, Sayaka Igarashi, Osamu Matsui, Toshifumi Gabata, Yasuni Nakanuma
BACKGROUND AND GOAL: Peribiliary cysts, which are known to be associated with various hepatobiliary diseases including alcoholic liver disease, have been reported to originate in the peribiliary glands along the biliary tree. The causal relationship between the peribiliary cysts and alcohol-related hepatic and pancreatic disease were examined in this study. METHODS AND RESULTS: Peribiliary cysts were surveyed in the radiologic reports of out-patients and in-patients at our hospital (between 2007 and 2011), and a total of 31 patients with peribiliary cysts were found; 9 patients were associated with alcoholic liver disease and 2 patients with alcoholic pancreatitis...
February 2014: Journal of Clinical Gastroenterology
Chihiro Gandou, Kenichi Harada, Yasunori Sato, Saya Igarashi, Motoko Sasaki, Hiroko Ikeda, Yasuni Nakanuma
Embryologically, intrahepatic small bile ducts arise from hepatic progenitor cells via ductal plates, whereas the pancreato-extrahepatic biliary progenitor cells expressing the transcription factors PDX1 and HES1 are reportedly involved in the development of the extrahepatic biliary tract and ventral pancreas. The expression of cellular markers characteristic of the different anatomical levels of the biliary tree and pancreas, as well as PDX1 and HES1, was examined in cholangiocarcinoma components of combined hepatocellular cholangiocarcinoma (12 cases), intrahepatic cholangiocarcinoma (21 cases), hilar cholangiocarcinoma (25 cases), and pancreatic ductal adenocarcinoma (18 cases)...
May 2013: Human Pathology
Rossella Semeraro, Guido Carpino, Vincenzo Cardinale, Paolo Onori, Raffaele Gentile, Alfredo Cantafora, Antonio Franchitto, Cristina Napoli, Maurizio Anceschi, Roberto Brunelli, Daniela Bosco, Alessia Torrice, Lola Reid, Eugenio Gaudio, Domenico Alvaro
BACKGROUND & AIMS: Biliary tree, liver, and pancreas share a common embryological origin. We previously demonstrated the presence of stem/progenitor cells of endodermal origin in the adult human extrahepatic biliary tree. This study evaluated the human foetal biliary trees as sources of stem/progenitor cells of multiple endodermal-derived mature fates. METHODS: Human foetal intrahepatic and extrahepatic biliary tree tissues and isolated cells were tested for cytoplasmic and surface markers of stem cells and committed progenitors, as well as endodermal transcription factors requisite for a liver versus pancreatic fate...
November 2012: Journal of Hepatology
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