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https://www.readbyqxmd.com/read/29244867/dietary-sources-and-intakes-of-folates-and-vitamin-b12-in-the-spanish-population-findings-from-the-anibes-study
#1
Teresa Partearroyo, María de Lourdes Samaniego-Vaesken, Emma Ruiz, Josune Olza, Javier Aranceta-Bartrina, Ángel Gil, Marcela González-Gross, Rosa M Ortega, Lluis Serra-Majem, Gregorio Varela-Moreiras
BACKGROUND: Folates and vitamin B12 are key nutrients in one-carbon metabolism and related diseases. Updated and plausible information on population intakes and their major dietary sources is scarce and urgently needed in Spain in order to increase the knowledge that can lead as previous step to prevention by fortification and supplementation policies. AIMS: The present study aims to evaluate main dietary folate and vitamin B12 sources and intakes in the Spanish population...
2017: PloS One
https://www.readbyqxmd.com/read/29244111/serum-albumin-as-a-prognostic-marker-for-serious-non-aids-endpoints-in-the-strategic-timing-of-antiretroviral-treatment-start-study
#2
Andreas Ronit, Shweta Sharma, Jason V Baker, Rosie Mngqibisa, Tristan Delory, Luis Caldeira, Nicaise Ndembi, Jens D Lundgren, Andrew N Phillips
Background: Serum albumin may be used to stratify human immunodeficiency virus (HIV)-infected persons with high CD4 count according to their risk of serious non-AIDS endpoints. Methods: Cox proportional hazards models were used to analyze the risk of serious non-AIDS events in the Strategic Timing of Antiretroviral Treatment (START) study (NCT00867048) with serum albumin as a fixed and time-updated predictor. Models with exclusion of events during initial follow-up years were built to assess the ability of serum albumin to predict beyond shorter periods of time...
December 13, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29243903/update-on-current-care-guideline-psoriasis-skin-and-joints
#3
(no author information available yet)
Psoriasis is a chronic, immune-mediated, inflammatory disorder of the skin and joints. Moderate-to-server cases are associated with an independent risk of comorbidity (cardiovascular diseases and diabetes) even after adjusting for risk factors, known to be more prevalent in psoriatics compared to normal population. The systemic underlying inflammation, analogous to that observed in rheumatoid arthritis, calls for a long-term effective treatment. Screening and treatment of cardiovascular risk factors is highly recommended...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29243770/adipose-derived-stem-cells-in-articular-cartilage-regeneration-current-concepts-and-optimization-strategies
#4
REVIEW
Xingjian Gu, Caixin Li, Feng Yin, Guanghua Yang
Knee osteoarthritis (KOA) is the most common progressive joint disorder associated with disability in the world. As a chronic disease, KOA has multifactorial etiology. However, the poor self-healing ability of the articular cartilage due to its intrinsic tissue hypovascularity and hypocellularity seems to be directly incriminated in the physio-pathological mechanism of KOA. While conventional therapies result in unfavorable clinical outcomes, regenerative cell therapies have shown great promise in articular cartilage regeneration...
December 15, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/29243470/update-on-current-care-guideline-venous-insufficiency-of-the-lower-limb
#5
(no author information available yet)
Venous insufficiency of the lower limb is a common disease. Diagnosis is based on symptoms, clinical findings and duplex ultrasound. Consideration and planning of invasive treatment cannot be performed without ultrasound. Vast majority of invasive treatments in superficial venous insufficiency can be done by ultrasound-guided endovenous methods with local anesthesia. Thermoablation (laser of radiofrequency) is the first-line treatment. There are promisisng endovenous methods for treatment of deep venous obstruction in selected cases...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29243402/national-burden-of-hospitalized-and-non-hospitalized-influenza-associated-severe-acute-respiratory-illness-in-kenya-2012-2014
#6
Jeanette A Dawa, Sandra S Chaves, Bryan Nyawanda, Henry N Njuguna, Carolyne Makokha, Nancy A Otieno, Omu Anzala, Marc-Alain Widdowson, Gideon O Emukule
BACKGROUND: Influenza-associated respiratory illness was substantial during the emergence of the 2009 influenza pandemic. Estimates of influenza burden in the post-pandemic period are unavailable to guide Kenyan vaccine policy. OBJECTIVES: To update estimates of hospitalized and non-hospitalized influenza-associated severe acute respiratory illness (SARI) during a post-pandemic period (2012-2014) and describe the incidence of disease by narrow age categories. METHODS: We used data from Siaya County Referral Hospital to estimate age-specific base rates of SARI...
December 15, 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29243000/rna-interference-based-therapy-and-its-delivery-systems
#7
Xiuhui Chen, Lingegowda S Mangala, Cristian Rodriguez-Aguayo, Xianchao Kong, Gabriel Lopez-Berestein, Anil K Sood
RNA interference (RNAi) is considered a highly specific approach for gene silencing and holds tremendous potential for treatment of various pathologic conditions such as cardiovascular diseases, viral infections, and cancer. Although gene silencing approaches such as RNAi are widely used in preclinical models, the clinical application of RNAi is challenging primarily because of the difficulty in achieving successful systemic delivery. Effective delivery systems are essential to enable the full therapeutic potential of RNAi...
December 14, 2017: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/29242280/results-of-fertility-sparing-surgery-for-expansile-and-infiltrative-mucinous-ovarian-cancers
#8
Sebastien Gouy, Marine Saidani, Amandine Maulard, Slim Bach-Hamba, Enrica Bentivegna, Alexandra Leary, Patricia Pautier, Mojgan Devouassoux-Shisheboran, Catherine Genestie, Philippe Morice
BACKGROUND: No series had been reported focusing on the results of fertility-sparing surgery in stage I mucinous ovarian cancers according to histotype (infiltrative vs. expansile). Investigating such outcomes was the aim of the present study. MATERIALS AND METHODS: The present study was a retrospective analysis of patients treated conservatively with preservation of the uterus and contralateral ovary from 1976 to 2016. The pathology of the tumors was reviewed by two expert pathologists according to the 2014 World Health Organization (WHO) classification criteria...
December 14, 2017: Oncologist
https://www.readbyqxmd.com/read/29242018/current-practice-in-cytoreductive-surgery-and-hipec-for-metastatic-peritoneal-disease-spanish-multicentric-survey
#9
Rafael Morales-Soriano, Neus Esteve-Pérez, Juan José Segura-Sampedro, Pedro Cascales-Campos, Pedro Barrios
INTRODUCTION: Radical Cytoreductive Surgery (CRS) with Hyperthermic Intraperitoneal Chemotherapy (HIPEC), has been proposed as the current standard of treatment for metastatic peritoneal disease by several tumors. Despite its widely utilization, there seems to be a great variability in their organization, clinical practice, and safety among centers. AIM OF THE STUDY: To obtain updated information on clinical practice in different perioperative areas of the CRS-HIPEC...
December 6, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29241876/update-in-ethiopathogeny-diagnosis-and-treatment-of-the-igg4-related-disease
#10
REVIEW
Fernando Martínez-Valle, Olimpia Orozco-Gálvez, Andreu Fernández-Codina
IgG4 related disease (IgG4-RD) is probably an autoimmune pathology of unknown etiology. Diverse interactions participate in its pathogen between the adaptive and innate immune systems, activating lymphocytes B and T which trigger the inflammatory cascade, which culminates in fibrosis of the organs and their malfunction. It can affect a multitude of organs simultaneously. The diagnosis is based on the correlation of clinical findings with anatomopathological results (lymphoplasmocitary infiltrate, storiform fibrosis, obliterative phlebitis and IgG4+plasmatic cell count) and with the presence of elevated IgG4 in serum, depending on the criteria used...
December 11, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/29241768/zika-virus-the-transboundary-pathogen-from-mosquito-and-updates
#11
REVIEW
Weili Kong, Jian Zhu
Zika virus (ZIKV) is a mosquito-borne flavivirus that was relatively obscure until outbreaks started in 2013. ZIKV is associated with neurological manifestations such as Guillan-Barrè Syndrome in adult and microcephaly in the newborn population. Although the majority of disease mechanisms of ZIKV is unclear, some information was updated with new scientific evidence. Currently, there are no approved drugs or vaccine that can be used for therapy during ZIKV infection. Based on the transmission mechanism of ZIKV, vector control and safe sex seem to be the most effective available preventive measures against ZIKV spread...
December 11, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29241452/pancreatic-schwannoma-a-case-report-and-an-updated-40-year-review-of-the-literature-yielding-68-cases
#12
Yuntong Ma, Bingqi Shen, Yingmei Jia, Yanji Luo, Yisu Tian, Zhi Dong, Wei Chen, Zi-Ping Li, Shi-Ting Feng
BACKGROUND: Pancreatic schwannoma is a rare tumor. Preoperative diagnosis of pancreatic schwannoma is challenging due to its tendency to mimic other lesions of the pancreas. We describe a case of pancreatic schwannoma and present a review of the cases currently reported in the English literature to identify characteristics of pancreatic schwannoma on imaging. CASE PRESENTATION: A 53-year-old male presented with a history of intermittent periumbilical abdominal pain and lower back pain for 1 week...
December 14, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29240976/clopidogrel-plus-aspirin-versus-aspirin-alone-for-preventing-cardiovascular-events
#13
REVIEW
Alessandro Squizzato, Marta Bellesini, Andrea Takeda, Saskia Middeldorp, Marco Paolo Donadini
BACKGROUND: Aspirin is the prophylactic antiplatelet drug of choice for people with cardiovascular disease. Adding a second antiplatelet drug to aspirin may produce additional benefit for people at high risk and people with established cardiovascular disease. This is an update to a previously published review from 2011. OBJECTIVES: To review the benefit and harm of adding clopidogrel to aspirin therapy for preventing cardiovascular events in people who have coronary disease, ischaemic cerebrovascular disease, peripheral arterial disease, or were at high risk of atherothrombotic disease, but did not have a coronary stent...
December 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29240957/non-coding-rnas-in-cardiac-%C3%AF-brosis-emerging-biomarkers-and-therapeutic-targets
#14
Zhongxiu Chen, Chen Li, Ke Lin, Huawei Cai, Weiqiang Ruan, Junyang Han, Li Rao
Non-coding RNAs (ncRNAs) are a class of RNA molecules that do not encode proteins. ncRNAs are involved in cell proliferation, apoptosis, differentiation, metabolism, and other physiological processes as well as the pathogenesis of diseases. Cardiac fibrosis is increasingly recognized as a common final pathway in advanced heart diseases. Many studies have shown that the occurrence and development of cardiac fibrosis is closely related to the regulation of ncRNAs. This review will highlight recent updates regarding the involvement of ncRNAs in cardiac fibrosis, and their potential as emerging biomarkers and therapeutic targets...
December 14, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/29240924/effect-of-omega-3-fatty-acids-on-cognition-an-updated-systematic-review-of-randomized-clinical-trials
#15
Oscar D Rangel-Huerta, Angel Gil
Context: The increasing number of studies on the effects of n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) on health, particularly cognition, in the last 5 years reflects the growing interest in this area of research. Objective: The aim for this systematic review was to evaluate the scientific evidence published in the last 5 years (2012-2017) on the effects of n-3 LC-PUFA intake on cognition, cognitive development, and cognitive decline to determine whether n-3 LC-PUFAs support cognitive development and prevent cognitive decline...
December 12, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/29240827/diagnostic-accuracy-research-in-glaucoma-is-still-incompletely-reported-an-application-of-standards-for-reporting-of-diagnostic-accuracy-studies-stard-2015
#16
Manuele Michelessi, Ersilia Lucenteforte, Alba Miele, Francesco Oddone, Giada Crescioli, Valeria Fameli, Daniël A Korevaar, Gianni Virgili
BACKGROUND: Research has shown a modest adherence of diagnostic test accuracy (DTA) studies in glaucoma to the Standards for Reporting of Diagnostic Accuracy Studies (STARD). We have applied the updated 30-item STARD 2015 checklist to a set of studies included in a Cochrane DTA systematic review of imaging tools for diagnosing manifest glaucoma. METHODS: Three pairs of reviewers, including one senior reviewer who assessed all studies, independently checked the adherence of each study to STARD 2015...
2017: PloS One
https://www.readbyqxmd.com/read/29240743/potential-for-public-health-success-in-tackling-the-hepatitis-c-virus-epidemic
#17
Ian Sheerin
New Zealand and Australia both now have the potential for a major public health success in controlling the hepatitis C virus epidemic. The burden of advanced liver disease and drug-related harm is increasing. However, a new range of anti-viral therapies have become available which offer a potential cure for most people with few side-effects. The epidemic is potentially preventable and hepatitis C is now curable. Although public health strategies for blood-borne viruses have been updated, they fall short of what is needed and should be upgraded with more emphasis on prevention, in order to achieve control of this epidemic...
December 15, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29240340/update-on-current-care-guideline-memory-disorders
#18
(no author information available yet)
Any complaint about memory should be examined. Diagnosis is based on international criteria. Basic evaluation consists of medical history, clinical evaluation, cognitive tests and brain imaging. When a diagnosis of Alzheimer's disease (AD), AD with cerebrovascular disease or with Lewy Body disease (LBD), or Dementia associated with Parkinson's disease or LBD is made, evidence-based medical therapy (acetylcholine esterase inhibitor or memantine) is indicated as a part of comprehensive care. In frontotemporal degenerations, these drugs are ineffective...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29239044/pathology-and-genetics-of-phaeochromocytoma-and-paraganglioma
#19
REVIEW
John Turchini, Veronica K Y Cheung, Arthur S Tischler, Ronald R De Krijger, Anthony J Gill
Phaeochromocytoma and paraganglioma (PHEO/PGL) are rare tumours with an estimated annual incidence of 3 per million. Advances in molecular understanding have led to the recognition that at least 30-40% arise in the setting of hereditary disease. Germline mutations in the succinate dehydrogenase genes SDHA, SDHB, SDHC, SDHD and SDHAF2 are the most prevalent of the more than 19 hereditary genetic abnormalities which have been reported. It is therefore recommended that, depending on local resources and availability, at least some degree of genetic testing should be offered to all PHEO/PGL patients, including those with clinically sporadic disease...
January 2018: Histopathology
https://www.readbyqxmd.com/read/29239033/what-s-new-in-pituitary-pathology
#20
REVIEW
Sylvia L Asa, Ozgur Mete
The increasing recognition of pituitary disorders and their impact on quality of life and longevity has made understanding of this small gland a subject of paramount importance. Pituitary pathology has seen many significant studies that indicate progress in identification and classification of pituitary lesions, as well as improved management strategies for patients. In this review, we outline six major areas of advances: (i) changes in terminology from 'adenoma' to 'pituitary neuroendocrine tumour'; (ii) reclassification of hormone-negative tumours based on transcription factor expression that defines lineage; (iii) updates in new pathogenetic mechanisms, including those that underlie rare lesions such as X-LAG and pituitary blastoma; (iv) clarification of hypophysitis due to immunotherapy, xanthomatous hypophysitis due to rupture of a Rathke's cleft cyst and IgG4 disease as the cause of inflammatory pseudotumour; (v) the consolidation of pituicytoma variants, including spindle cell oncocytoma and granular cell tumour based on thyroid transcription factor-1 (TTF-1) reactivity; and (vi) the pathogenetic mechanisms that distinguish papillary from adamantinomatous craniopharyngioma...
January 2018: Histopathology
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