keyword
https://read.qxmd.com/read/38536602/endoscopic-loco-regional-treatment-in-controlling-pancreatic-neuroendocrine-tumors-pnets-behavior-a-case-series-and-literature-review
#21
JOURNAL ARTICLE
Cosmas Rinaldi Adithya Lesmana
Pancreatic neuroendocrine tumors (PNETs) are considered rare pancreatic neoplasms, and it is a challenging disease entity due to its indolent behavior and is difficult to manage. Diagnostic challenge is usually found in the imaging-based approach, such as transabdominal ultrasound, abdominal CT scan, and abdominal MRI. Surgery is still the main key player in controlling the disease. The main problems in clinical practice are the early detection of small PNETs lesion and non-functional PNET (NF-PNET) cases. Most cases usually come with large tumor size or metastatic disease...
March 27, 2024: Clinical Journal of Gastroenterology
https://read.qxmd.com/read/38536596/pathologic-maternal-and-neonatal-outcomes-associated-with-programmed-embryo-transfer-potential-etiologies-and-strategies-for-prevention
#22
REVIEW
Kirk P Conrad, Frauke von Versen-Höynck, Valerie L Baker
PURPOSE: In the first of two companion papers, we comprehensively reviewed the recent evidence in the primary literature, which addressed the increased prevalence of hypertensive disorders of pregnancy, late-onset or term preeclampsia, fetal overgrowth, postterm birth, and placenta accreta in women conceiving by in vitro fertilization. The preponderance of evidence implicated frozen embryo transfer cycles and, specifically, those employing programmed endometrial preparations, in the higher risk for these adverse maternal and neonatal pregnancy outcomes...
March 27, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38536594/pathologic-maternal-and-neonatal-outcomes-associated-with-programmed-embryo-transfer
#23
REVIEW
Kirk P Conrad, Frauke von Versen-Höynck, Valerie L Baker
PURPOSE: In this first of two companion papers, we critically review the evidence recently published in the primary literature, which addresses adverse maternal and neonatal pregnancy outcomes associated with programmed embryo transfer cycles. We next consider whether these pathological pregnancy outcomes might be attributable to traditional risk factors, unknown parental factors, embryo culture, culture duration, or cryopreservation. Finally, in the second companion article, we explore potential etiologies and suggest strategies for prevention...
March 27, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38536576/bruton-tyrosine-kinase-inhibition-an-effective-strategy-to-manage-waldenstr%C3%A3-m-macroglobulinemia
#24
REVIEW
Reema K Tawfiq, Jithma P Abeykoon, Prashant Kapoor
PURPOSE OF REVIEW: The treatment of Waldenström macroglobulinemia (WM) has evolved over the past decade. With the seminal discoveries of MYD88 and CXCR warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) mutations in WM cells, our understanding of the disease biology and treatment has improved. The development of a new class of agents, Bruton tyrosine kinase inhibitors (BTKi), has substantially impacted the treatment paradigm of WM. Herein, we review the current and emerging BTKi and the evidence for their use in WM...
March 27, 2024: Current Hematologic Malignancy Reports
https://read.qxmd.com/read/38536535/association-of-lower-extremity-peripheral-arterial-disease-with-quantitative-muscle-features-from-computed-tomography-angiography
#25
JOURNAL ARTICLE
Ge Hu, Yuexin Chen, Chunlin Mu, Xinyue Zhang, Yun Wang, Yining Wang, Huadan Xue, Daming Zhang, Zhengyu Jin
OBJECTIVES: To explore the association between lower extremity muscle features from CTA and peripheral arterial disease (PAD) severity using digital subtraction angiography (DSA) as reference standard. METHODS: Informed consent was waived for this Institutional Review Board approved retrospective study. PAD patients were recruited from July 2016 to September 2020. Two radiologists evaluated PAD severity on DSA and CTA using runoff score. The patients were divided into two groups: mild PAD (DSA score ≤ 7) vs...
March 27, 2024: Insights Into Imaging
https://read.qxmd.com/read/38536531/minimally-invasive-approaches-to-diagnose-and-monitor-eosinophilic-gi-diseases
#26
REVIEW
Ellie J M Furuta, Glenn T Furuta, Robin Shandas
PURPOSE OF REVIEW: This review seeks to understand novel avenues for eosinophilic GI disease management. Biomarkers offer a unique and non-invasive approach to tracking EoE disease progression. While no biomarkers have definitively met the diagnostic criteria for eosinophilic GI diseases, some biomarkers have been shown to be associated with disease activity. Here, we examine the potential of recently studied biomarkers. RECENT FINDINGS: Current research shows advancements in blood, luminal fluid, and breath testing...
March 27, 2024: Current Allergy and Asthma Reports
https://read.qxmd.com/read/38536526/pharmacological-and-immunomodulatory-modes-of-action-of-medically-important-phytochemicals-against-arthritis-a-molecular-insight
#27
REVIEW
Aqsa, Shaukat Ali, Muhammad Summer, Saima Yousaf, Laiba Nazakat, Shehzeen Noor
Arthritis is a common illness that affects joints and it may result in inflammation and pain. Even though arthritis usually affects older people, it can also affect children, adults, and both genders. Numerous arthritic mouse models have been developed but the CIA model of rheumatoid arthritis (RA) has received the most attention. With the use of steroids, DMARDs, and NSAIDs, therapy objectives such as reduced disease incidence and better pain management are achieved. Long-term usage of these therapeutic approaches may have negative side effects...
March 27, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38536523/suitability-of-reduced-dose-glucocorticoids-therapy-regimen-for-antibody-associated-vasculitis-patients-with-tb-a-retrospective-study
#28
JOURNAL ARTICLE
Rui Wen, Jingni Xiao, Ning Ding, Yong Zhong, Qiong Yuan, Jiali Li, Qi Wang, Hebin Xie, Jiao Qin
INTENTION: Immunosuppressive therapy is the major treatment approach for patients with anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). Due to impaired cellular immunological function and the use of glucocorticoids and immunosuppressants, AAV patients are predisposed to opportunistic infections, including tuberculosis (TB). This retrospective study aims to analyze the clinical characteristics of patients with AAV and TB and explore suitable glucocorticoid regimens for them...
March 27, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38536516/the-role-of-oxidative-stress-in-the-pathogenesis-of-ocular-diseases-an-overview
#29
REVIEW
Miao Zhang, Ruixue Zhang, Xiaoyue Zhao, Zhongyu Ma, Jizhao Xin, Shuqin Xu, Dadong Guo
Dysregulation of oxidative stress serves as a pivotal predisposing or exacerbating factor in the intricate development of numerous pathological processes and diseases. In recent years, substantial evidence has illuminated the crucial role of reactive oxygen species (ROS) in many fundamental cellular functions, including proliferation, inflammation, apoptosis, and gene expression. Notably, producing free radicals within ROS profoundly impacts a wide range of biomolecules, such as proteins and DNA, instigating cellular damage and impairing vital cellular functions...
March 27, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38536501/identification-of-potential-core-genes-in-pseudoexfoliation-using-bioinformatics-analysis-and-retrospective-analysis-of-84-patients-with-this-disease
#30
REVIEW
Xiaodi Liu, Yanli Qin, Bixia Wei, Ling Ding
BACKGROUND: Pseudoexfoliation (XFS) is a common cause of glaucoma in nowadays. Because of XFS causing irreversible blindness secondary to glaucoma (XFG), this study aims to identify the current prevalence of XFS among Xinjiang Province of China, and identify the hub genes involved in XFS. METHODS: A retrospective chart review was conducted from 2007 to 2019 for patients aged 50 and older. All patients with XFS or XFG diagnosed by slit lamp exam were identified through chart review...
March 27, 2024: International Ophthalmology
https://read.qxmd.com/read/38536500/the-interactions-of-subcellular-organelles-in-pulmonary-fibrosis-induced-by-carbon-black-nanoparticles-a-comprehensive-review
#31
REVIEW
Lei Bao, Qingping Liu, Jingyuan Wang, Lili Shi, Yaxian Pang, Yujie Niu, Rong Zhang
Owing to the widespread use and improper emissions of carbon black nanoparticles (CBNPs), the adverse effects of CBNPs on human health have attracted much attention. In toxicological research, carbon black is frequently utilized as a negative control because of its low toxicity and poor solubility. However, recent studies have indicated that inhalation exposure to CBNPs could be a risk factor for severe and prolonged pulmonary inflammation and fibrosis. At present, the pathogenesis of pulmonary fibrosis induced by CBNPs is still not fully elucidated, but it is known that with small particle size and large surface area, CBNPs are more easily ingested by cells, leading to organelle damage and abnormal interactions between organelles...
March 27, 2024: Archives of Toxicology
https://read.qxmd.com/read/38536476/herombopag-for-the-treatment-of-persistent-thrombocytopenia-following-hematopoietic-stem-cell-transplantation
#32
JOURNAL ARTICLE
Miao Zhou, Tongyu Li, Ping Zhang, Yanli Lai, Lixia Sheng, Guifang Ouyang
Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) stands as a pivotal treatment for hematologic malignancies, often considered the sole effective treatment option. A frequent complication following allo-HSCT is poor graft function (PGF), with one of its primary manifestations being persistent thrombocytopenia (PT), comprising prolonged isolated thrombocytopenia (PIT) and secondary failure of platelet recovery (SFPR). Conventional treatment methods have had poor efficacy and a high transplantation-associated mortality rate...
March 27, 2024: Annals of Hematology
https://read.qxmd.com/read/38536450/surgical-management-of-chiari-ii-malformation-a-systematic-review-of-literature
#33
REVIEW
Rafael C C Vencio, Adriano M Lino-Filho, Renata C F Bonfim, Nayara M Pereira, Cilmária L Franco, Paulo Ronaldo J Ribeiro, Bárbara A Morais
PURPOSE: Chiari II malformation (CM-II) is a congenital malformation of the posterior fossa associated with myelomeningocele. Of the symptomatic patients, 10-33% require surgical treatment. To this date, there is not a consensus about the best surgical technique, and whether to do duroplasty. METHODS: A literature search of the PubMed database and crossed references was performed, per PRISMA guidelines. Data regarding demographic features, extent of cervicomedullary deformity, clinical presentation, surgical techniques, and clinical outcomes were extracted...
March 27, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/38536448/arterial-spin-labelling-magnetic-resonance-imaging-and-perfusion-patterns-in-neurocognitive-and-other-mental-disorders-a-systematic-review
#34
REVIEW
Rita Ferreira, António J Bastos-Leite
We reviewed 33 original research studies assessing brain perfusion, using consensus guidelines from a "white paper" issued by the International Society for Magnetic Resonance in Medicine Perfusion Study Group and the European Cooperation in Science and Technology Action BM1103 ("Arterial Spin Labelling Initiative in Dementia"; https://www.cost.eu/actions/BM1103/ ). The studies were published between 2011 and 2023 and included participants with subjective cognitive decline plus; neurocognitive disorders, including mild cognitive impairment (MCI), Alzheimer's disease (AD), frontotemporal lobar degeneration (FTLD), dementia with Lewy bodies (DLB) and vascular cognitive impairment (VCI); as well as schizophrenia spectrum disorders, bipolar and major depressive disorders, autism spectrum disorder, attention-deficit/hyperactivity disorder, panic disorder and alcohol use disorder...
March 27, 2024: Neuroradiology
https://read.qxmd.com/read/38536416/transcatheter-arterial-tendinopathy-embolization-as-a-treatment-for-painful-and-refractory-tendinopathy-a-systematic-review-and-meta-analysis
#35
JOURNAL ARTICLE
Yan Epelboym, Colette Glaser, Zhou Lan, Jacob C Mandell, Ezra Burch, Timothy Killoran, Ali Guermazi
OBJECTIVE: Transcatheter arterial embolization (TAE) is a novel minimally invasive therapy for painful tendinopathy in patients with pain refractory to conservative management. The purpose of this study was to evaluate evidence on the efficacy of TAE for tendinopathy related pain. MATERIALS AND METHODS: Using Embase, PubMed, and Web of Science, a systematic review and meta-analysis was performed to identify studies evaluating TAE for painful tendinopathy. The primary outcome measure was change in pain scale score at 6 months...
March 27, 2024: Skeletal Radiology
https://read.qxmd.com/read/38536234/target-product-profile-for-a-machine-learning-automated-retinal-imaging-analysis-software-for-use-in-english-diabetic-eye-screening-protocol-for-a-mixed-methods-study
#36
JOURNAL ARTICLE
Trystan Macdonald, Jacqueline Dinnes, Gregory Maniatopoulos, Sian Taylor-Phillips, Bethany Shinkins, Jeffry Hogg, John Kevin Dunbar, Ameenat Lola Solebo, Hannah Sutton, John Attwood, Michael Pogose, Rosalind Given-Wilson, Felix Greaves, Carl Macrae, Russell Pearson, Daniel Bamford, Adnan Tufail, Xiaoxuan Liu, Alastair K Denniston
BACKGROUND: Diabetic eye screening (DES) represents a significant opportunity for the application of machine learning (ML) technologies, which may improve clinical and service outcomes. However, successful integration of ML into DES requires careful product development, evaluation, and implementation. Target product profiles (TPPs) summarize the requirements necessary for successful implementation so these can guide product development and evaluation. OBJECTIVE: This study aims to produce a TPP for an ML-automated retinal imaging analysis software (ML-ARIAS) system for use in DES in England...
March 27, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38536202/venous-disorders-as-an-occupational-disease-a-systematic-review-on-epidemiology-pathophysiology-and-modification-strategies
#37
REVIEW
Tobias Hirsch, Uwe Wahl, Eberhard Rabe
<b/> Background: Forced postures are common in the workplace. Work in the primary economic sector is characterised by a high degree of physical activity and movement; however, activities in the secondary and tertiary sectors commonly require workers to stand or sit. An expansion of the tertiary sector in recent decades has meant that people in industrialised and emerging economies primarily sit or stand at work. The aim of the systematic review was to identify occupational factors relating to the presence of chronic venous disease (CVD), to place these in the context of developments in the workplace, and to determine whether measures are in place to prevent CVD...
March 27, 2024: VASA. Zeitschrift Für Gefässkrankheiten
https://read.qxmd.com/read/38536196/offloading-and-adherence-through-technological-advancements-modern-approaches-for-better-foot-care-in-diabetes
#38
REVIEW
Sicco A Bus, Neil D Reeves, David G Armstrong, Bijan Najafi
OBJECTIVE: This manuscript aims to provide a review and synthesis of contemporary advancements in footwear, sensor technology for remote monitoring, and digital health, with a focus on improving offloading and measuring and enhancing adherence to offloading in diabetic foot care. METHODS: A narrative literature review was conducted by sourcing peer-reviewed articles, clinical studies, and technological innovations. This paper includes a review of various strategies, from specifically designed footwear, smart insoles and boots to using digital health interventions, which aim to offload plantar pressure and help prevent and manage wounds more effectively by improving the adherence to such offloading...
February 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38536171/a-revised-definition-of-left-bundle-branch-block-using-time-to-notch-in-lead-i
#39
JOURNAL ARTICLE
Jeremy S Treger, Ahmad B Allaw, Pouyan Razminia, Dipayon Roy, Amulya Gampa, Swati Rao, Andrew D Beaser, Srinath Yeshwant, Zaid Aziz, Cevher Ozcan, Gaurav A Upadhyay
IMPORTANCE: Current left bundle branch block (LBBB) criteria are based on animal experiments or mathematical models of cardiac tissue conduction and may misclassify patients. Improved criteria would impact referral decisions and device type for cardiac resynchronization therapy. OBJECTIVE: To develop a simple new criterion for LBBB based on electrophysiological studies of human patients, and then to validate this criterion in an independent population. DESIGN, SETTING, AND PARTICIPANTS: In this diagnostic study, the derivation cohort was from a single-center, prospective study of patients undergoing electrophysiological study from March 2016 through November 2019...
March 27, 2024: JAMA Cardiology
https://read.qxmd.com/read/38536160/validation-of-thermal-imaging-and-the-alt-70-prediction-model-to-differentiate-cellulitis-from-pseudocellulitis
#40
JOURNAL ARTICLE
Michael S Pulia, Rebecca J Schwei, Roxana Alexandridis, Michael R Lasarev, Edward Harwick, Robert Glinert, Ambar Haleem, Jamie Hess, Thomas D Keenan, Joseph A McBride, Robert Redwood
IMPORTANCE: Cellulitis is misdiagnosed in up to 30% of cases due to mimic conditions termed pseudocellulitis. The resulting overuse of antibiotics is a threat to patient safety and public health. Surface thermal imaging and the ALT-70 (asymmetry, leukocytosis, tachycardia, and age ≥70 years) prediction model have been proposed as tools to help differentiate cellulitis from pseudocellulitis. OBJECTIVES: To validate differences in skin surface temperatures between patients with cellulitis and patients with pseudocellulitis, assess the optimal temperature measure and cut point for differentiating cellulitis from pseudocellulitis, and compare the performance of skin surface temperature and the ALT-70 prediction model in differentiating cellulitis from pseudocellulitis...
March 27, 2024: JAMA Dermatology
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