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Procalcitonin AND Neonatal sepsis

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https://www.readbyqxmd.com/read/29577181/a-comparative-evaluation-of-presepsin-with-procalcitonin-and-crp-in-diagnosing-neonatal-sepsis
#1
Neeraj Kumar, Rajeshwar Dayal, Pratibha Singh, Sunit Pathak, Vishal Pooniya, Ankur Goyal, Raj Kamal, K K Mohanty
The objectives of this study were to study the clinical and biochemical profile of neonates with sepsis and to evaluate the diagnostic role of presepsin and its comparison with C-reactive protein (CRP) and Procalcitonin (PCT). This study was conducted from March 2015 through October 2016 in Neonatal intensive care unit (NICU) at S N Medical College, Agra. Neonates with ≥1 clinical features of sepsis and/or two risk factors were included. A total of 41 cases and 41 controls were taken. Blood sample was taken for all investigations...
March 26, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29567889/evaluation-of-procalcitonin-as-a-diagnostic-marker-in-neonatal-sepsis
#2
Marie Victor Pravin Charles, Ramakrishnan Kalaivani, Soma Venkatesh, Arunava Kali, Kunigal Srinivasiah Seetha
Context: Neonatal sepsis is an early infection occurring within 28 days of the postnatal life. It has nonspecific signs and symptoms which make the diagnosis cumbersome. It inflicts an increase in morbidity and mortality among neonates. Procalcitonin (PCT) is yet another acute phase reactant, which is synthesized by the C-cells of thyroid gland. Aims: The aim of our study is to evaluate PCT as a diagnostic marker of neonatal sepsis in comparison with C-reactive protein (CRP)...
January 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29563816/the-diagnostic-utility-of-procalcitonin-interleukin-6-and-interleukin-8-and-hyaluronic-acid-in-the-norwegian-consensus-definition-for-early-onset-neonatal-sepsis-eons
#3
Britt Nakstad
Introduction: A key challenge in identifying serious bacterial infection in new born infants is the nonspecific clinical presentation of early-onset neonatal sepsis (EONS). Routinely used C-reactive protein, white blood cell count, and platelets are nonspecific. We assessed the diagnostic utility of single biomarkers or combinations of procalcitonin (PCT), interleukin (IL)-6, IL-8, and hyaluronic acid (HA) in newborn infant with EONS, and in human umbilical cord blood (HUCB) from deliveries with chorioamnionitis...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29488601/-procalcitonin-guided-decision-making-for-duration-of-antibiotic-therapy-in-neonates-with-suspected-early-onset-sepsis
#4
Marta Aravena
No abstract text is available yet for this article.
October 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29476345/the-diagnostic-accuracy-of-presepsin-in-neonatal-sepsis-a-meta-analysis
#5
REVIEW
Ioannis Bellos, Georgia Fitrou, Vasilios Pergialiotis, Nikolaos Thomakos, Despina N Perrea, Georgios Daskalakis
There is growing evidence that presepsin is a promising biomarker in the diagnosis of sepsis in adults. The objective of our study is to investigate current evidence related to the diagnostic accuracy of presepsin in neonatal sepsis. To accomplish this, we searched the Medline (1966-2017), Scopus (2004-2017), Clinicaltrials.gov (2008-2017), EMBASE (1980-2017), Cochrane Central Register of Controlled Trials CENTRAL (1999-2017), and Google Scholar (2004-2017) databases. Eleven studies were included in the present meta-analysis, with a total number of 783 neonates...
February 23, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29343506/how-to-use%C3%A2-procalcitonin
#6
Philip Robinson, Surjo Kiran De
Diagnosing bacterial infection in the unwell or febrile child is a common challenge faced by all paediatricians. Despite the advent of novel molecular techniques, there is ongoing need for diagnostic assays with adequate performance and turnaround time to facilitate safe clinical decision-making when bacterial sepsis is suspected, such as whether to commence empirical treatment with antibiotics. Procalcitonin is an established marker of infection that has a potential role in the diagnosis and exclusion of serious or invasive bacterial infection in neonates and children...
January 17, 2018: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/29312687/procalcitonin-use-for-shorter-courses-of-antibiotic-therapy-in-suspected-early-onset-neonatal-sepsis-are-we-getting-there
#7
EDITORIAL
Despoina Gkentzi, Gabriel Dimitriou
No abstract text is available yet for this article.
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29287292/procalcitonin-as-predictor-of-bacterial-infection-in-meconium-aspiration-syndrome
#8
Mahendiran K, Prerna Batra, M M A Faridi, N P Singh
BACKGROUND:  There is a lack of definite consensus on indications for initiating antibiotics in neonates with meconium aspiration syndrome (MAS), instigating researchers to search for a biomarker that can help differentiate MAS from MAS with bacterial infection. OBJECTIVE:  Our primary objective was to compare serum procalcitonin (PCT) levels in full-term vigorous neonates having MAS with or without bacterial infection. MATERIALS AND METHODS:  Seventy term vigorous neonates with diagnosis of MAS were enrolled...
December 29, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/29219889/the-value-of-neutrophil-to-lymphocyte-ratio-and-platelet-to-lymphocyte-ratio-for-detecting-early-onset-neonatal-sepsis
#9
Emrah Can, Şahin Hamilcikan, Ceren Can
OBJECTIVE: The purpose of this study was to investigate the relationship between neonate early-onset sepsis (EOS) and the neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR) of term neonates. MATERIALS AND METHODS: This prospective observational study was conducted with term neonates diagnosed with EOS compared with 44 healthy controls. Exclusion criteria were prematurity, postmaturity, small or large for gestational age according to week of pregnancy, preeclampsia, gestational diabetes mellitus, chorioamnionitis, congenital major anomalies, and cyanotic congenital heart disease...
December 6, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29203386/procalcitonin-the-marker-of-pediatric-bacterial-infection
#10
Mohammad Yousef Memar, Mojtaba Varshochi, Behrooz Shokouhi, Mohammad Asgharzadeh, Hossein Samadi Kafil
Timely recognition of systemic bacterial infections in pediatric care setting is the basis for effective treatment and control. This review provides an overview of procalcitonin (PCT) as an early marker for the detection of severe, invasive bacterial infection in children. Almost all articles on biochemical property and clinical studies in PubMed and Scopus databases regarding their use in pediatric infections and the use of PCT as a marker of bacterial infections were examined. Various methods and analyzers are currently available for the evaluation of PCT...
December 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29185950/procalcitonin-and-neonatal-sepsis-is-this-the-biomarker-we-are-looking-for
#11
Susan Givens Bell
Researchers estimate the incidence of early onset sepsis as 0.77-1/1,000 live births. It remains as one of the leading causes of neonatal deaths. Clinicians and researchers continue to search for biomarkers for specific neonatal disease processes. Clinicians frequently trend C-reactive protein levels during evaluation for neonatal sepsis. Recently, researchers have begun to explore procalcitonin as a potentially useful diagnostic marker for neonatal sepsis.
November 1, 2017: Neonatal Network: NN
https://www.readbyqxmd.com/read/29131403/does-a-procalcitonin-guided-approach-to-term-and-late-preterm-neonates-with-suspected-early-onset-sepsis-safely-decrease-unnecessary-antibiotic-exposure
#12
https://www.readbyqxmd.com/read/28962140/relationship-between-blood-lactic-acid-blood-procalcitonin-c-reactive-protein-and-neonatal-sepsis-and-corresponding-prognostic-significance-in-sick-children
#13
Yongfeng Jia, Ying Wang, Xinhua Yu
The study was conducted to evaluate the relationship between the blood lactic acid (BLA) level, serum procalcitonin (PCT), C-reactive protein (CRP) and the severity and prognosis of neonatal sepsis. A retrospective analysis was conducted on 90 children with sepsis admitted into the Intensive Care Unit (ICU) of the Hubei Institute for Nationalities Af liated Hospital hospital. Patients were divided into the non-survival group and the survival group. Severity of the 90 patients was evaluated according to Neonatal Critical Illness Score (NCIS)...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28774361/-value-of-combined-determination-of-neutrophil-cd64-and-procalcitonin-in-early-diagnosis-of-neonatal-bacterial-infection
#14
Dao-Jian Qin, Zong-Sheng Tang, Shu-Li Chen, Xue-Mei Xu, Shuang-Gen Mao, Shi-Fa Zhang
OBJECTIVE: To investigate the value of combined determination of neutrophil CD64 and procalcitonin (PCT) in the early diagnosis of neonatal bacterial infection. METHODS: According to discharge diagnosis, 37 neonates with bacterial infection were divided into sepsis (n=15) and ordinary infection (non-sepsis) groups (n=22). Twenty-one neonates without infection who were hospitalized during the same period of time were enrolled as the control group. Venous blood samples were collected immediately after admission...
August 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28769143/zonulin-a-potential-marker-of-intestine-injury-in-newborns
#15
Anna Tarko, Anna Suchojad, Marta Michalec, Małgorzata Majcherczyk, Aniceta Brzozowska, Iwona Maruniak-Chudek
INTRODUCTION: Zonulin (ZO), a new diagnostic biomarker of intestinal permeability, was tested in newborns presenting symptoms of infection and/or inflammation of the gut or being at risk of intestinal pathology. MATERIAL AND METHODS: Serum ZO was assessed in 81 newborns diagnosed with sepsis, necrotizing enterocolitis (NEC), rotavirus infection, and gastroschisis, also in extremely low gestational age babies, and in controls (healthy newborns). ZO concentration was compared to C-reactive protein (CRP) and procalcitonin (PCT) values, leucocyte and platelet count, basic demographic data, and the value of the Neonatal Therapeutic Intervention Scoring System (NTISS)...
2017: Disease Markers
https://www.readbyqxmd.com/read/28719503/central-peripheral-temperature-monitoring-as-a-marker-for-diagnosing-late-onset-neonatal-sepsis
#16
José Luis Leante-Castellanos, Antonio Martínez-Gimeno, Manuel Cidrás-Pidré, Gerardo Martínez-Munar, Ana García-González, Carmen Fuentes-Gutiérrez
BACKGROUND: The prognosis for late-onset sepsis depends largely on a timely diagnosis. We assess central-peripheral temperature difference monitoring as a marker for late-onset neonatal sepsis diagnosis. METHODS: We performed a prospective, observational study focusing on a cohort of 129 very low-birth-weight infants. Thermal gradient alteration was defined as a difference of > 2°C maintained during 4 hours. We then determined its association with the late-onset sepsis variable through logistic regression...
December 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28711318/procalcitonin-guided-decision-making-for-duration-of-antibiotic-therapy-in-neonates-with-suspected-early-onset-sepsis-a-multicentre-randomised-controlled-trial-neopins
#17
Martin Stocker, Wendy van Herk, Salhab El Helou, Sourabh Dutta, Matteo S Fontana, Frank A B A Schuerman, Rita K van den Tooren-de Groot, Jantien W Wieringa, Jan Janota, Laura H van der Meer-Kappelle, Rob Moonen, Sintha D Sie, Esther de Vries, Albertine E Donker, Urs Zimmerman, Luregn J Schlapbach, Amerik C de Mol, Angelique Hoffman-Haringsma, Madan Roy, Maren Tomaske, René F Kornelisse, Juliette van Gijsel, Eline G Visser, Sten P Willemsen, Annemarie M C van Rossum
BACKGROUND: Up to 7% of term and late-preterm neonates in high-income countries receive antibiotics during the first 3 days of life because of suspected early-onset sepsis. The prevalence of culture-proven early-onset sepsis is 0·1% or less in high-income countries, suggesting substantial overtreatment. We assess whether procalcitonin-guided decision making for suspected early-onset sepsis can safely reduce the duration of antibiotic treatment. METHODS: We did this randomised controlled intervention trial in Dutch (n=11), Swiss (n=4), Canadian (n=2), and Czech (n=1) hospitals...
August 26, 2017: Lancet
https://www.readbyqxmd.com/read/28471985/the-clinical-significance-of-scd14-st-for-blood-biomarker-in-neonatal-hematosepsis-a-diagnostic-accuracy-study
#18
Ting Xiao, Li-Ping Chen, Li-Hua Zhang, Fu-Huang Lai, Li Zhang, Qun-Feng Qiu, Rong-Liang Que, SiSi Xie, Ding-Chang Wu
Hematosepsis is a systemic inflammatory response syndrome (SIRS) with suspected or confirmed infection, which is the most common infectious disease in clinical neonatal intensive care unit. As the rapid development of neonatal hematosepsis caused by various basic diseases, the mortality rate is high, and there are some sequelae.We report the lasted study to date with 96 cases from Fujian Longyan First Hospital between 2013 and 2015. The aim of our study is to explore the value of soluble cluster of differentiation 14 subtype (sCD14-ST) in whole blood for differential diagnosis of neonatal hematosepsis at an early stage, and used in evaluation of the severity about sepsis combined with acute physiology and chronic health evaluation II (APACHE-II) score, procalcitonin (PCT), C reactive protein (CRP), and leukocyte (WBC)...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28442521/application-of-flow-cytometry-in-the-early-diagnosis-of-neonatal-sepsis
#19
Mustafa Aydin, Sumeyye Barut, H Handan Akbulut, Sit Ucar, Aysen Orman
GOALS: To raise awareness of the utility of flow cytometric detection of inflammatory markers in the early diagnosis of neonatal sepsis. PROCEDURES: In accordance with the Töllner scoring system, cases with ≥10 points are accepted as having "clinical sepsis" and cases with 0-4 points as having "no sepsis". The study group consisted of 50 newborns with clinical sepsis as well as a control group of 50 newborns without sepsis. In all cases, blood counts, C-reactive protein (CRP) levels, and procalcitonin (PCT) levels were recorded...
March 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28438138/accuracy-of-serum-procalcitonin-for-the-diagnosis-of-sepsis-in-neonates-and-children-with-systemic-inflammatory-syndrome-a-meta-analysis
#20
REVIEW
Giuseppe Pontrelli, Franco De Crescenzo, Roberto Buzzetti, Alessandro Jenkner, Sara Balduzzi, Francesca Calò Carducci, Donato Amodio, Maia De Luca, Sara Chiurchiù, Elin Haf Davies, Giorgia Copponi, Alessandra Simonetti, Elena Ferretti, Valeria Di Franco, Virginia Rasi, Martina Della Corte, Luca Gramatica, Marco Ciabattini, Susanna Livadiotti, Paolo Rossi
BACKGROUND: A number of biomarkers have been studied for the diagnosis of sepsis in paediatrics, but no gold standard has been identified. Procalcitonin (PCT) was demonstrated to be an accurate biomarker for the diagnosis of sepsis in adults and showed to be promising in paediatrics. Our study reviewed the diagnostic accuracy of PCT as an early biomarker of sepsis in neonates and children with suspected sepsis. METHODS: A comprehensive literature search was carried out in Medline/Pubmed, Embase, ISI Web of Science, CINAHL and Cochrane Library, for studies assessing PCT accuracy in the diagnosis of sepsis in children and neonates with suspected sepsis...
April 24, 2017: BMC Infectious Diseases
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