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human bocavirus

Xuefeng Deng, Peng Xu, Wei Zou, Weiran Shen, Jianxin Peng, Kaiyu Liu, John F Engelhardt, Ziying Yan, Jianming Qiu
: Human bocavirus 1 (HBoV1), an emerging human pathogenic respiratory virus, is a member of the genus Bocaparvovirus of the Parvoviridae family. In human airway epithelia air-liquid interface (HAE-ALI) cultures, HBoV1 infection initiates a DNA damage response (DDR), activating all three phosphatidylinositol 3-kinase-related kinases (PI3KKs): ATM, ATR and DNA-PKcs. In this context, activation of PI3KKs is a requirement for amplification of the HBoV1 genome (PLoS Pathog., 2016; 12:e1005399), and HBoV1 replicates only in terminally differentiated, non-dividing cells...
October 12, 2016: Journal of Virology
Nicklas Sundell, Lars-Magnus Andersson, Robin Brittain-Long, Magnus Lindh, Johan Westin
BACKGROUND: The relation between weather conditions, viral transmission and seasonal activity of respiratory viruses is not fully understood. OBJECTIVES: To investigate the impact of outdoor weather in a temperate climate setting on the seasonal epidemiology of viruses causing respiratory tract infections, particularly influenza A (IFA). STUDY DESIGN: In total, 20,062 clinical nasopharyngeal swab samples referred for detection of respiratory pathogens using a multiplex PCR panel, between October 2010 and July 2013, were included...
October 7, 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Tatyana V Spichak, Svetlana B Yatsyshina, Lubov К Кatosova, Svetlana S Кim, Matti O Korppi
: The role that rhinoviruses, enteroviruses, parainfluenza viruses, coronaviruses and human bocavirus play in pediatric pneumonia is insufficiently studied. We used polymerase chain reaction (PCR) to study 9 virus groups, including 16 different viruses or viral strains, in 56 ambulatory children with radiologically confirmed community-acquired pneumonia (CAP). The same tests were carried out on 474 apparently healthy control children of the same age and sex. The mean age of children with CAP was 6...
October 6, 2016: European Journal of Pediatrics
Sylvia Taylor, Pio Lopez, Lily Weckx, Charissa Borja-Tabora, Rolando Ulloa-Gutierrez, Eduardo Lazcano-Ponce, Angkool Kerdpanich, Miguel Angel Rodriguez Weber, Abiel Mascareñas de Los Santos, Juan-Carlos Tinoco, Marco Aurelio P Safadi, Fong Seng Lim, Marcela Hernandez-de Mezerville, Idis Faingezicht, Aurelio Cruz-Valdez, Yang Feng, Ping Li, Serge Durviaux, Gerco Haars, Sumita Roy-Ghanta, David W Vaughn, Terry Nolan
BACKGROUND: Better population data on respiratory viruses in children in tropical and southern hemisphere countries is needed. METHODS: The epidemiology of respiratory viruses among healthy children (6 months to <10 years) with influenza-like illness (ILI) was determined in a population sample derived from an influenza vaccine trial (NCT01051661) in 17 centers in eight countries (Australia, South East Asia and Latin America). Active surveillance for ILI was conducted for approximately 1 year (between February 2010 and August 2011), with PCR analysis of nasal and throat swabs...
September 22, 2016: Journal of Infection
Kattareeya Kumthip, Pattara Khamrin, Niwat Maneekarn
Poliovirus (PV) is typically transmitted by the fecal-oral route, which means that the risk of infection and virus distribution could be achieved by exposure to the virus contaminated in food and water. The aim of this study was to determine the occurrence of PV strains by detecting the virus in pediatric patients who admitted to the hospitals with diarrhea in Chiang Mai, Thailand during 2010-2015. By applying a reverse transcription-polymerase chain reaction and nucleotide sequencing analysis of 1,300 stool specimens collected from pediatric patients, PVs were detected at 0...
September 24, 2016: Journal of Medical Virology
Shixing Yang, Yan Wang, Wang Li, Zhaobin Fan, Lili Jiang, Yuan Lin, Xingli Fu, Quan Shen, Zixuan Sun, Xiaochun Wang, Xutao Deng, Wen Zhang, Eric Delwart
Bocaviruses have been found in the feces of humans and a variety of animals, including pigs, cattle, dogs, gorillas, cats, and sea lions. Here, we have characterized the almost complete genome (5224 nt) of a novel bocavirus from feces of domestic minks, which has been provisionally named mink bocavirus. The NS1 protein of mink bocavirus shared 36.9-52 % amino acid sequence identities with those of other known bocaviruses and phylogenetically clustered with bocaviruses from other carnivores. According to the genetic distance-based criteria, mink bocavirus qualifies as a novel species of bocavirus...
August 12, 2016: Virus Genes
Min Zhao, Runan Zhu, Yuan Qian, Jie Deng, Fang Wang, Yu Sun, Huijin Dong, Liying Liu, Liping Jia, Linqing Zhao
OBJECTIVES: Viral infections caused by human bocaviruses 1-4 (HBoV1-4) are more complicated than previously believed. A retrospective, large-scale study was undertaken to explore the prevalence of HBoV1-4 in pediatric patients with various infectious diseases and delineate their phylogenetic characteristics. METHODS: Clinical samples from four specimen types, including 4,941 respiratory, 2,239 cerebrospinal fluid (CSF), 2,619 serum, and 1,121 fecal specimens, collected from pediatric patients with various infectious diseases were screened for HBoV1-4...
2016: PloS One
Weiran Shen, Xuefeng Deng, Wei Zou, John F Engelhardt, Ziying Yan, Jianming Qiu
UNLABELLED: Parvoviruses are single-stranded DNA viruses that use the palindromic structures at the ends of the viral genome for their replication. The mechanism of parvovirus replication has been studied mostly in the dependoparvovirus adeno-associated virus 2 (AAV2) and the protoparvovirus minute virus of mice (MVM). Here, we used human bocavirus 1 (HBoV1) to understand the replication mechanism of bocaparvovirus. HBoV1 is pathogenic to humans, causing acute respiratory tract infections, especially in young children under 2 years old...
September 1, 2016: Journal of Virology
Qingshi Liu, Zhenfeng Zhang, Zhenhua Zheng, Caishang Zheng, Yan Liu, Qinxue Hu, Xianliang Ke, Hanzhong Wang
Human bocavirus (HBoV), a parvovirus, is a single-stranded DNA etiologic agent causing lower respiratory tract infections in young children worldwide. Nuclear factor kappa B (NF-κB) transcription factors play crucial roles in clearance of invading viruses through activation of many physiological processes. Previous investigation showed that HBoV infection could significantly upregulate the level of TNF-α which is a strong NF-κB stimulator. Here we investigated whether HBoV proteins modulate TNF-α-mediated activation of the NF-κB signaling pathway...
2016: Scientific Reports
M Verónica Vera-Garate, Juan Manuel Rudi, Alejandra Gómez, Fabiana Molina, María Florencia Viotti, Lucila Ortellao, Judith Pierini, Natalia Sioli, Raquel Cociglio, Ana María Zamora, Gustavo Ru Z de Huidobro, Dardo Costas, Susana López de Caillou, Stella Maris Sánchez, Nora Mamaní, Rosanna Leva, Graciela Rodríguez, Sara Gallardo, Gabriela Kusznierz
BACKGROUND: A large proportion of acute respiratory tract infections (ARTI) remain without etiologic diagnosis, reason why new pathogens are investigated continuously. Human bocavirus (HBoV) was discovered in 2005, as a new member of Parvoviridae family and proposed to cause ARTI. AIM: To know the prevalence of HBoV among pediatric populations hospitalized for ARTI in two provinces of Argentina: Santa Fe and Tucuman; and to describe epidemiological and clinical aspects associated to its detection...
April 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
M Iaconelli, M Divizia, S Della Libera, P Di Bonito, Giuseppina La Rosa
The prevalence and genetic diversity of human bocaviruses (HBoVs) in sewage water samples are largely unknown. In this study, 134 raw sewage samples from 25 wastewater treatment plants (WTPs) in Italy were analyzed by nested PCR and sequencing using species-specific primer pairs and broad-range primer pairs targeting the capsid proteins VP1/VP2. A large number of samples (106, 79.1 %) were positive for HBoV. Out of these, 49 were classified as HBoV species 2, and 27 as species 3. For the remaining 30 samples, sequencing results showed mixed electropherograms...
June 16, 2016: Food and Environmental Virology
Yanqun Wang, Yamin Li, Jun Liu, Yanjie Zhao, Zhengde Xie, Jun Shen, Wenjie Tan
OBJECTIVES: To investigate the genetic character of Human bocavirus (HBoV) among children with severe acute respiratory infection (SARI) in China. METHODS: We screened 993 respiratory samples for HBoV by PCR among hospitalized children with SARI between September 2007 and March 2014. Four of HBoV1 samples were selected for complete genomes analysis by next-generation sequencing. RESULTS: The results show that 200 (20.1%) out of 993 samples were HBoV-positive, most of these HBoV belong to HBoV1 subtype (n = 197), HBoV2 (n = 1) and HBoV3 (n = 2) were also detected...
August 2016: Journal of Infection
Gerardo D Deluca, María Cecilia Urquijo, Carolina Passarella, César Picón, Dimas Picón, María Acosta, Carina Rovira, Héctor M Marín
Acute respiratory infection (ARI) is the most frequent pathology along human life, being the most common cause of morbidity and mortality in children under 5 years. The aim of this study was to determine the frequency of bocavirus (BoV) in infants under 5 years with symptoms of ARI from north Argentina (Chaco province). The study was performed on nasopharyngeal aspirates from 488 patients, in the period of January-December 2014. The samples were tested by real time PCR and 36 positive BoV cases (7.4%) were detected...
2016: Medicina
Neha Lasure, Varanasi Gopalkrishna
Although acute gastroenteritis is a major public health problem worldwide, ∼40% of the cases remain undiagnosed for any etiological agent. Human Bocavirus (HBoV) has been detected frequently in feces of diarrhoeic children suggesting its possible etiological involvement in the disease. HBoV has not been reported in association with acute gastroenteritis from India. Fecal samples (n = 418) collected from children (age ≤5 years) hospitalized with acute gastroenteritis, between January 2009 and December 2011, from three local hospitals were examined for presence of HBoV using PCR targeting the partial VP1/VP2 capsid region (∼575bp) followed by phylogenetic analysis...
June 8, 2016: Journal of Medical Virology
Yi Chen, Fanghua Liu, Changbing Wang, Mingqi Zhao, Li Deng, Jiayu Zhong, Yingying Zhang, Jun Ye, Shuping Jing, Zetao Cheng, Yongxin Guan, Yi Ma, Yuanyuan Sun, Bing Zhu, Qiwei Zhang
BACKGROUND: Acute respiratory infections (ARI) are the major worldwide health problem associated with high morbidity and mortality rates. Human adenovirus (HAdV) is one of the most common pathogens associated with viral ARI, and thus calls for specific diagnosis and better understanding of the epidemiology and clinical characteristics. METHODS: Total 4,130 children with ARI requiring hospitalization from 2012 to 2013 were retrospectively studied. Throat swab specimens were collected from each patient...
2016: PloS One
Ahmed S Abdel-Moneim, Hosam A El-Fol, Mahmoud M Kamel, Ahmed S A Soliman, Emad A Mahdi, Ahmed S El-Gammal, Taha Z M Mahran
Human bocavirus (HBoV) is a prevalent virus worldwide and is mainly associated with respiratory disorders. Recently, it was detected in several disease conditions, including cancers. Colorectal cancer (CRC) is the third main cause of cancers worldwide. Risk factors that initiate cell transformation include nutritional, hereditary and infectious causes. The aim of the current study was to screen for the presence of HBoV in solid tumors of colorectal cancer and to determine the genotypes of the detected strains...
August 2016: Archives of Virology
Cristina Calvo, María Luz García-García, Francisco Pozo, Daniel Carballo, Eduardo Martínez-Monteserín, Inmaculada Casas
The human bocavirus (hBoV) has been identified in respiratory infections in children in a large number of studies. Despite this, the pathogenic role of the HBoV is under discussion. The main objectives of the study were: to determine the incidence of HBoV in hospitalized children; to describe the main clinical features of the positive children; and to compare the data with those from other viral infections in the same population. A prospective study was performed between 2005 and 2013 including children up to 14 years old with respiratory infection admitted to the Severo Ochoa Hospital (Spain)...
April 28, 2016: Journal of Medical Virology
Asad Ali, Tauseef Akhund, Gohar Javed Warraich, Fatima Aziz, Najeeb Rahman, Fayyaz Ahmed Umrani, Shahida Qureshi, William A Petri, Zulfiqar Bhutta, Anita K M Zaidi, Molly A Hughes
The objective of this study was to determine the incidence of respiratory viruses associated with severe pneumonia among children less than 2 years of age in the rural district of Matiari in Sindh, Pakistan. This study was a community-based prospective cohort active surveillance of infants enrolled at birth and followed for 2 years. Cases were identified using the World Health Organization's Integrated Management of Childhood Illnesses' definition of severe pneumonia. Nasopharyngeal swabs were obtained for assessment by multiplex RT-PCR for eight viruses and their subtypes, including RSV, influenza virus, human metapneumovirus, enterovirus/rhinovirus, coronavirus, parainfluenza virus, adenovirus, and human bocavirus...
November 2016: Journal of Medical Virology
Maryam Tabasi, Talat Mokhtari-Azad, Mohammad Reza Eshraghian, Azadeh Shadab, Somayeh Shatizadeh, Nazanin Zahra Shafiei-Jandaghi, Jila Yavarian
BACKGROUND AND OBJECTIVES: Human bocavirus (HBoV) is a newly discovered parvovirus. It has been detected primarily in children with acute respiratory tract infections. This study was conducted to clarify the frequency and genotype circulation pattern of HBoV in Iran. MATERIALS AND METHODS: Conventional PCR was performed on throat swabs of patients less than two years of age with respiratory illnesses during fall and winter 2012-2013. RESULTS: HBoV virus DNA was detected in 15 of 140 samples (10...
February 2016: Iranian Journal of Microbiology
Mayda Finianos, Randi Issa, Martin D Curran, Claude Afif, Maryam Rajab, Jihad Irani, Noha Hakimeh, Amal Naous, Marie-Joelle Hajj, Pierre Hajj, Tamima El Jisr, Mira El Chaar
Acute respiratory tract viral infections occur worldwide and are one of the major global burdens of diseases in children. The aim of this study was to determine the viral etiology of respiratory infections in hospitalized children, to understand the viral seasonality in a major Lebanese hospital, and to correlate disease severity and the presence of virus. Over a 1-year period, nasal and throat swabs were collected from 236 pediatric patients, aged 16-year old or less and hospitalized for acute respiratory illness...
November 2016: Journal of Medical Virology
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