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https://www.readbyqxmd.com/read/27923400/allele-specific-expression-in-the-human-heart-and-its-application-to-postoperative-atrial-fibrillation-and-myocardial-ischemia
#1
Martin I Sigurdsson, Louis Saddic, Mahyar Heydarpour, Tzuu-Wang Chang, Prem Shekar, Sary Aranki, Gregory S Couper, Stanton K Shernan, Jon G Seidman, Simon C Body, Jochen D Muehlschlegel
BACKGROUND: Allele-specific expression (ASE) is differential expression of each of the two chromosomal alleles of an autosomal gene. We assessed ASE patterns in the human left atrium (LA, n = 62) and paired samples from the left ventricle (LV, n = 76) before and after ischemia, and tested the utility of differential ASE to identify genes associated with postoperative atrial fibrillation (poAF) and myocardial ischemia. METHODS: Following genotyping from whole blood and whole-genome sequencing of LA and LV samples, we called ASE using sequences overlapping heterozygous SNPs using rigorous quality control to minimize false ASE calling...
December 6, 2016: Genome Medicine
https://www.readbyqxmd.com/read/27822408/microarray-expression-profiling-identifies-genes-including-cytokines-and-biofunctions-as-diapedesis-associated-with-a-brain-metastasis-from-a-papillary-thyroid-carcinoma
#2
Hans-Juergen Schulten, Deema Hussein, Fatima Al-Adwani, Sajjad Karim, Jaudah Al-Maghrabi, Mona Al-Sharif, Awatif Jamal, Sherin Bakhashab, Jolanta Weaver, Fahad Al-Ghamdi, Saleh S Baeesa, Mohammed Bangash, Adeel Chaudhary, Mohammed Al-Qahtani
Brain metastatic papillary thyroid carcinomas (PTCs) are afflicted with unfavorable prognosis; however, the underlying molecular genetics of these rare metastases are virtually unknown. In this study, we compared whole transcript microarray expression profiles of a BRAF mutant, brain metastasis from a PTC, including its technical replicate (TR), with eight non-brain metastatic PTCs and eight primary brain tumors. The top 95 probe sets (false discovery rate (FDR) p-value < 0.05 and fold change (FC) > 2) that were differentially expressed between the brain metastatic PTC, including the TR, and both, non-brain metastatic PTCs and primary brain tumors were in the vast majority upregulated and comprise, e...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/27521061/expression-patterns-of-homeobox-genes-in-the-mouse-vomeronasal-organ-at-postnatal-stages
#3
Isabelle Chang, Marta Parrilla
Homeodomain proteins are encoded by homeobox genes and regulate development and differentiation in many neuronal systems. The mouse vomeronasal organ (VNO) generates in situ mature chemosensory neurons from stem cells. The roles of homeodomain proteins in neuronal differentiation in the VNO are poorly understood. Here we have characterized the expression patterns of 28 homeobox genes in the VNO of C57BL/6 mice at postnatal stages using multicolor fluorescent in situ hybridization. We identified 11 homeobox genes (Dlx3, Dlx4, Emx2, Lhx2, Meis1, Pbx3, Pknox2, Pou6f1, Tshz2, Zhx1, Zhx3) that were expressed exclusively in neurons; 4 homeobox genes (Pax6, Six1, Tgif1, Zfhx3) that were expressed in all non-neuronal cell populations, with Pax6, Six1 and Tgif1 also expressed in some neuronal progenitors and precursors; 12 homeobox genes (Adnp, Cux1, Dlx5, Dlx6, Meis2, Pbx2, Pknox1, Pou2f1, Satb1, Tshz1, Tshz3, Zhx2) with expression in both neuronal and non-neuronal cell populations; and one homeobox gene (Hopx) that was exclusively expressed in the non-sensory epithelium...
July 2016: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/27197076/zinc-fingers-and-homeoboxes-2-zhx2-regulates-sexually-dimorphic-cyp-gene-expression-in-the-adult-mouse-liver
#4
Kate Townsend Creasy, Jieyun Jiang, Hui Ren, Martha L Peterson, Brett T Spear
The mammalian cytochrome P450 (Cyp) gene family encodes a large number of structurally related enzymes that catalyze a variety of metabolic and detoxification reactions. The liver is the primary site of Cyp expression in terms of expression levels and number of expressed genes, consistent with this organ's essential role in metabolism of endogenous and xenobiotic compounds. Many Cyp genes exhibit sexually dimorphic expression. For example, Cyp2a4 is expressed significantly higher in the adult liver of female mice compared to male mice...
2016: Gene Expression
https://www.readbyqxmd.com/read/27085157/update-of-the-effect-estimates-for-common-variants-associated-with-carotid-intima-media-thickness-within-four-independent-samples-the-bonn-imt-family-study-the-heinz-nixdorf-recall-study-the-saphir-study-and-the-bruneck-study
#5
Marie H Geisel, Stefan Coassin, Nicole Heßler, Marcus Bauer, Lewin Eisele, Raimund Erbel, Margot Haun, Frauke Hennig, Susanna Moskau-Hartmann, Barbara Hoffmann, Karl-Heinz Jöckel, Lyudmyla Kedenko, Stefan Kiechl, Barbara Kollerits, Amir-Abbas Mahabadi, Susanne Moebus, Gudrun Nürnberg, Peter Nürnberg, Bernhard Paulweber, Maren Vens, Johann Willeit, Karin Willeit, Thomas Klockgether, Andreas Ziegler, André Scherag, Florian Kronenberg
Carotid intima media thickness (cIMT) is a marker for subclinical atherosclerosis. The most recent genome-wide association meta-analysis (GWAMA) from the CHARGE consortium identified four genomic regions showing either significant (ZHX2, APOC1, PINX1) or suggestive evidence (SLC17A4) for an association. Here we assess these four cIMT loci in a pooled analysis of four independent studies including 5446 individuals by providing updated unbiased effect estimates of the cIMT association signals. The pooled estimates of our four independent samples pointed in the same direction and were similar to those of the GWAMA...
June 2016: Atherosclerosis
https://www.readbyqxmd.com/read/26881698/increased-dna-methylation-and-reduced-expression-of-transcription-factors-in-human-osteoarthritis-cartilage
#6
Oscar Alvarez-Garcia, Kathleen M Fisch, Nathan E Wineinger, Ryuichiro Akagi, Masahiko Saito, Takahisa Sasho, Andrew I Su, Martin K Lotz
OBJECTIVE: To analyze the methylome of normal and osteoarthritic (OA) knee articular cartilage and to determine the role of DNA methylation in the regulation of gene expression in vitro. METHODS: DNA was isolated from human normal (n = 11) and OA (n = 12) knee articular cartilage and analyzed using the Infinium HumanMethylation450 BeadChip array. To integrate methylation and transcription, RNA sequencing was performed on normal and OA cartilage and validated by quantitative polymerase chain reaction...
August 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/26679602/proliferation-and-osteo-odontogenic-differentiation-of-stem-cells-from-apical-papilla-regulated-by-zinc-fingers-and-homeoboxes-2-an-in%C3%A2-vitro-study
#7
Fang Wan, Lifen Gao, Yating Lu, Hongxin Ma, Hongxing Wang, Xiaohong Liang, Yan Wang, Chunhong Ma
In the process of tooth root development, stem cells from the apical papilla (SCAPs) can differentiate into odontoblasts and form root dentin, however, molecules regulating SCAPs differentiation have not been elucidated. Zinc fingers and homeoboxes 2 (ZHX2) is a novel transcriptional inhibitor. It is reported to modulate the development of nerve cells, liver cells, B cells, red blood cells, and so on. However, the role of ZHX2 in tooth root development remains unclear. In this study, we explored the potential role of ZHX2 in the process of SCAPs differentiation...
January 15, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/26522117/prenatal-diagnosis-and-array-comparative-genomic-hybridization-characterization-of-interstitial-deletions-of-8q23-3-q24-11-and-8q24-13-associated-with-langer-giedion-syndrome-cornelia-de-lange-syndrome-and-haploinsufficiency-of-trps1-rad21-and-ext1
#8
Chih-Ping Chen, Ming-Huei Lin, Yi-Yung Chen, Schu-Rern Chern, Yen-Ni Chen, Peih-Shan Wu, Chen-Wen Pan, Meng-Shan Lee, Wayseen Wang
OBJECTIVE: The aim of this research was to present prenatal diagnosis of Langer-Giedion syndrome (LGS/TRPS type II) and Cornelia de Lange syndrome-4 (CDLS4). MATERIALS AND METHODS: A 36-year-old woman underwent amniocentesis at 17 weeks of gestation because of advanced maternal age. Conventional cytogenetic analysis of amniocentesis revealed an interstitial deletion of chromosome 8q or del(8)(q23.3q24.13). Level II prenatal ultrasound examination revealed craniofacial dysmorphism...
October 2015: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/26406991/aberrantly-expressed-otx-homeobox-genes-deregulate-b-cell-differentiation-in-hodgkin-lymphoma
#9
Stefan Nagel, Stefan Ehrentraut, Corinna Meyer, Maren Kaufmann, Hans G Drexler, Roderick A F MacLeod
In Hodgkin lymphoma (HL) we recently reported that deregulated homeobox gene MSX1 mediates repression of the B-cell specific transcription factor ZHX2. In this study we investigated regulation of MSX1 in this B-cell malignancy. Accordingly, we analyzed expression and function of OTX homeobox genes which activate MSX1 transcription during embryonal development in the neural plate border region. Our data demonstrate that OTX1 and OTX2 are aberrantly expressed in both HL patients and cell lines. Moreover, both OTX loci are targeted by genomic gains in overexpressing cell lines...
2015: PloS One
https://www.readbyqxmd.com/read/26085845/preimplantation-factor-pif-promotes-embryotrophic-and-neuroprotective-decidual-genes-effect-negated-by-epidermal-growth-factor
#10
Christina M Duzyj, Michael J Paidas, Lellean Jebailey, Jing Shun Huang, Eytan R Barnea
BACKGROUND: Intimate embryo-maternal interaction is paramount for pregnancy success post-implantation. The embryo follows a specific developmental timeline starting with neural system, dependent on endogenous and decidual factors. Beyond altered genetics/epigenetics, post-natal diseases may initiate at prenatal/neonatal, post-natal period, or through a continuum. Preimplantation factor (PIF) secreted by viable embryos promotes implantation and trophoblast invasion. Synthetic PIF reverses neuroinflammation in non-pregnant models...
2014: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/25746325/genetic-association-and-gene-smoking-interaction-study-of-carotid-intima-media-thickness-at-five-gwas-indicated-genes-the-bogalusa-heart-study
#11
Changwei Li, Wei Chen, Fan Jiang, Jeannette Simino, Sathanur R Srinivasan, Gerald S Berenson, Hao Mei
OBJECTIVES: To examine the associations of five GWAS-identified genes with carotid intima-media thickness (IMT) in a biracial sample from the Bogalusa Heart Study, and evaluate their participation in gene-smoking interactions. METHODS: Far wall IMTs of common carotid arteries were measured using high-resolution B-mode ultrasound. Both the gene-smoking interactions and single-marker associations were evaluated by linear models of carotid IMT levels, while the gene-based analyses were assessed through the truncated product method...
May 15, 2015: Gene
https://www.readbyqxmd.com/read/25625310/prevalence-of-chromosomal-rearrangements-involving-non-ets-genes-in-prostate-cancer
#12
Martina Kluth, Rami Galal, Antje Krohn, Joachim Weischenfeldt, Christina Tsourlakis, Lisa Paustian, Ramin Ahrary, Malik Ahmed, Sekander Scherzai, Anne Meyer, Hüseyin Sirma, Jan Korbel, Guido Sauter, Thorsten Schlomm, Ronald Simon, Sarah Minner
Prostate cancer is characterized by structural rearrangements, most frequently including translocations between androgen-dependent genes and members of the ETS family of transcription factor like TMPRSS2:ERG. In a recent whole genome sequencing study we identified 140 gene fusions that were unrelated to ETS genes in 11 prostate cancers. The aim of the present study was to estimate the prevalence of non-ETS gene fusions. We randomly selected 27 of these rearrangements and analyzed them by fluorescence in situ hybridization (FISH) in a tissue microarray format containing 500 prostate cancers...
April 2015: International Journal of Oncology
https://www.readbyqxmd.com/read/25473899/zhx2-enhances-the-cytotoxicity-of-chemotherapeutic-drugs-in-liver-tumor-cells-by-repressing-mdr1-via-interfering-with-nf-ya
#13
Hongxin Ma, Xuetian Yue, Lifen Gao, Xiaohong Liang, Wenjiang Yan, Zhenyu Zhang, Haixia Shan, Hualin Zhang, Brett T Spear, Chunhong Ma
We previously reported the tumor suppressor function of Zinc-fingers and homeoboxes 2 (ZHX2) in hepatocellular carcinoma (HCC). Other studies indicate the association of increased ZHX2 expression with improved response to high dose chemotherapy in multiple myeloma. Here, we aim to test whether increased ZHX2 levels in HCC cells repress multidrug resistance 1(MDR1) expression resulting in increased sensitivity to chemotherapeutic drugs. We showed evidence that increased ZHX2 levels correlated with reduced MDR1 expression and enhanced the cytotoxicity of CDDP and ADM in different HCC cell lines...
January 20, 2015: Oncotarget
https://www.readbyqxmd.com/read/25195714/reduced-nucleic-zhx2-involves-in-oncogenic-activation-of-glypican-3-in-human-hepatocellular-carcinoma
#14
Fang Luan, Peng Liu, Hongxin Ma, Xuetian Yue, Jun Liu, Lifen Gao, Xiaohong Liang, Chunhong Ma
Glypican 3 (GPC3) has been paid particular attention owing to its potential as diagnosis marker for hepatocellular carcinoma (HCC). Identifying the mechanisms regulating the reactivation of GPC3 in HCC appears to be clinically meaningful. Previous study identified zinc-fingers and homeoboxes 2 (ZHX2) as transcriptional factor responsible for postnatal repression of GPC3 in mice. Here, in this study, we provided the first evidence that down regulated ZHX2 is responsible for GPC3 reactivation in HCC. First, inverse correlation of ZHX2 with GPC3 expression was shown in cultured liver cell lines...
October 2014: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/25043849/deregulated-fox-genes-in-hodgkin-lymphoma
#15
Stefan Nagel, Corinna Meyer, Maren Kaufmann, Hans G Drexler, Roderick A F MacLeod
FOX genes encode transcription factors which regulate basic developmental processes during embryogenesis and in the adult. Several FOX genes show deregulated expression in particular malignancies, representing oncogenes or tumor suppressors. Here, we screened six Hodgkin lymphoma (HL) cell lines for FOX gene activity by comparative microarray profiling, revealing overexpression of FOXC1 and FOXD1, and reduced transcription of FOXN3, FOXO1, and FOXP1. In silico expression analyses of these FOX gene candidates in HL patient samples supported the cell line data...
November 2014: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/24916381/analysis-of-adult-cerebral-cortex-and-hippocampus-transcriptomes-reveals-unique-molecular-changes-in-the-ts1cje-mouse-model-of-down-syndrome
#16
COMPARATIVE STUDY
Faycal Guedj, Jeroen L A Pennings, Heather C Wick, Diana W Bianchi
We investigated gene expression and functional differences between Ts1Cje mice and wild-type (WT) littermates in adult cerebral cortex and hippocampus. These two brain regions are affected in people with Down syndrome, but have not been previously molecularly characterized in Ts1Cje mice. Total RNA was prepared from the brains of 8-10-week-old Ts1Cje mice (n = 6) and WT littermates (n = 5) and hybridized to Affymetrix 1.0 ST gene mouse arrays. Differentially regulated genes were identified and used to perform in silico functional analyses to better characterize dysregulated pathways in both brain regions...
January 2015: Brain Pathology
https://www.readbyqxmd.com/read/24463079/zbtb20-is-involved-in-liver-regeneration-after-partial-hepatectomy-in-mouse
#17
Ming-Zhe Weng, Peng-Yuan Zhuang, Zhen-Yu Hei, Pei-Yi Lin, Zhi-Sheng Chen, Ying-Bin Liu, Zhi-Wei Quan, Zhao-Hui Tang
BACKGROUND: A better understanding of the molecular mechanisms in liver regeneration holds promise for exploring the new potential therapy for liver failure. The present study was to investigate the role of zinc finger and BTB domain-containing protein 20 (ZBTB20), a potential factor associated with liver regeneration, in a model of 70% hepatectomy in mice. METHODS: Parameters for liver proliferation such as liver/body ratio and BrdU positivity were obtained via direct measurement and immunohistochemistry...
February 2014: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/24064680/construction-of-a-recombinant-eukaryotic-human-zhx1-gene-expression-plasmid-and-the-role-of-zhx1-in-hepatocellular-carcinoma
#18
COMPARATIVE STUDY
Jianping Wang, Dejie Liu, Xiaohong Liang, Lifen Gao, Xuetian Yue, Yang Yang, Chunhong Ma, Jun Liu
The zinc-fingers and homeoboxes protein 1 (ZHX1) consists of 873 amino acid residues, is localized in the cell nucleus and appears to act as a transcriptional repressor. Previous studies have shown that ZHX1 interacts with nuclear factor Y subunit α (NF-YA), DNA methyltransferases (DNMT) 3B and ZHX2, all of which are involved in tumorigenesis. However, the exact role of ZHX1 in tumorigenesis remains unknown. The aim of the current study was to construct a recombinant eukaryotic expression plasmid containing the human ZHX1 (hZHX1) gene and to investigate the biological activities of ZHX1 in hepatocellular carcinoma (HCC)...
November 2013: Molecular Medicine Reports
https://www.readbyqxmd.com/read/23879678/identification-of-candidate-intergenic-risk-loci-in-autism-spectrum-disorder
#19
Susan Walker, Stephen W Scherer
BACKGROUND: Copy number variations (CNVs) and DNA sequence alterations affecting specific neuronal genes are established risk factors for Autism Spectrum Disorder (ASD). In what is largely considered a genetic condition, so far, these mutations account for ~20% of individuals having an ASD diagnosis. However, non-coding genomic sequence also contains functional elements introducing additional disease risk loci for investigation. RESULTS: We have performed genome-wide analyses and identified rare inherited CNVs affecting non-genic intervals in 41 of 1491 (3%) of ASD cases examined...
2013: BMC Genomics
https://www.readbyqxmd.com/read/23867865/exome-sequencing-in-familial-corticobasal-degeneration
#20
Robert Fekete, Matthew Bainbridge, Jose Fidel Baizabal-Carvallo, Andreana Rivera, Bradley Miller, Peicheng Du, Vladyslav Kholodovych, Suzanne Powell, William Ondo
BACKGROUND: Corticobasal degeneration (CBD) is a neurodegenerative, sporadic disorder of unknown cause. Few familial cases have been described. OBJECTIVE: We aim to characterize the clinical, imaging, pathological and genetic features of two familial cases of CBD. METHODS: We describe two first cousins with CBD associated with atypical MRI findings. We performed exome sequencing in both subjects and in an unaffected first cousin of similar age...
November 2013: Parkinsonism & related Disorders
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