Mihir R Atreya, Tellen D Bennett, Alon Geva, E Vincent S Faustino, Colin M Rogerson, Riad Lutfi, Natalie Z Cvijanovich, Michael T Bigham, Jeffrey Nowak, Adam J Schwarz, Torrey Baines, Bereketeab Haileselassie, Neal J Thomas, Yuan Luo, L Nelson Sanchez-Pinto
OBJECTIVES: Identification of children with sepsis-associated multiple organ dysfunction syndrome (MODS) at risk for poor outcomes remains a challenge. We sought to the determine reproducibility of the data-driven "persistent hypoxemia, encephalopathy, and shock" (PHES) phenotype and determine its association with inflammatory and endothelial biomarkers, as well as biomarker-based pediatric risk strata. DESIGN: We retrained and validated a random forest classifier using organ dysfunction subscores in the 2012-2018 electronic health record (EHR) dataset used to derive the PHES phenotype...
March 11, 2024: Pediatric Critical Care Medicine