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https://www.readbyqxmd.com/read/28039902/long-term-safety-and-efficacy-of-telbivudine-in-infants-born-to-mothers-treated-during-the-second-or-third-trimesters-of-pregnancy
#1
Guo-Rong Han, Hong-Xiu Jiang, Cui-Min Wang, Yi Ding, Gen-Ju Wang, Xin Yue, Liu Zhou, Wei Zhao
Telbivudine, an FDA pregnancy category B drug, has been found to reduce hepatitis B virus (HBV) perinatal transmission with no safety concerns in infants aged up to 1 year. This study evaluated the long-term efficacy and safety of telbivudine in 214 infants born to 210 pregnant women with chronic hepatitis B infection who were treated with telbivudine during pregnancy (weeks 20-32 of gestation). The infants were followed for up to 5 years after birth. The efficacy endpoint was the rate of perinatal transmission, which was established by HBsAg and HBV DNA levels at 7 and 12 months...
December 31, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28018875/diagnostic-accuracy-of-developmental-screening-in-primary-care-at-the-18-month-health-supervision-visit-a-cross-sectional-study
#2
Meta van den Heuvel, Cornelia M Borkhoff, Christine Koroshegyi, Weeda Zabih, Sijmen A Reijneveld, Jonathon Maguire, Catherine Birken, Patricia Parkin
BACKGROUND: Communication delays are often the first presenting problem in infants with a range of developmental disabilities. Our objective was to assess the validity of the 18-month Nipissing District Developmental Screen compared with the Infant Toddler Checklist, a validated tool for detecting expressive language and other communication delays. METHODS: A cross-sectional design was used. Children aged 18-20 months were recruited during scheduled health supervision visits...
October 2016: CMAJ Open
https://www.readbyqxmd.com/read/28005729/assessment-of-deformational-plagiocephaly-severity-and-neonatal-developmental-delay
#3
Stefani C Fontana, Debora Daniels, Thomas Greaves, Niaman Nazir, Jeff Searl, Brian T Andrews
Deformational plagiocephaly (DP) in infants has been associated with developmental delay that can last until adolescence. Despite this association and a 5-fold increase in incidence of DP over the past 2 decades, there are currently no guidelines regarding screening for developmental delay or identification of which infants with DP are at the greatest risk of delay. A prospective, nonrandomized study was performed. Infants diagnosed with DP who had no prior intervention were eligible for enrollment. Cranial deformity was measured by cross-cranial measurements using calipers, and developmental delay was measured using the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III)...
November 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28004033/psychomotor-development-in-cri-du-chat-syndrome-comparison-in-two-italian-cohorts-with-different-rehabilitation-methods
#4
Andrea Guala, Marianna Spunton, Fabio Tognon, Marilena Pedrinazzi, Luisa Medolago, Paola Cerutti Mainardi, Silvia Spairani, Michela Malacarne, Enrico Finale, Mario Comelli, Cesare Danesino
The Cri du Chat syndrome (CdC) is a rare genetic disorder caused by variable size deletions of the short arm of chromosome 5 (5p-). It is well known that home-reared patients show better performances as compared to institutionalised cases, and it was reported that continuous educational intervention can ameliorate their performances. To assess the efficacy of educational intervention and to develop new CdC oriented programs of rehabilitation, we compare the results obtained for many developmental skills in two groups of CdC patients undergoing two different rehabilitation programs...
2016: TheScientificWorldJournal
https://www.readbyqxmd.com/read/28001274/language-behavior-and-neurodevelopment-in-joubert-syndrome-a-case-report
#5
Dionísia Aparecida Cusin Lamônica, Camila da Costa Ribeiro, Antonio Richieri-Costa, Célia Maria Giacheti
The Joubert syndrome (JS) is a rare, heterogeneous genetic condition among the ciliopathies. More than 20 genes have been identified associated with this phenotype. The main manifestations include hypotonia, ataxia, psychomotor retardation, ocular-motor apraxia and neonatal respiratory abnormalities. The objective of this paper was to present language and neurodevelopmental findings of an individual diagnosed with JS. The following procedures were performed: anamnesis, clinical genetic evaluation observation of communicative behavior, evaluation of language, the Denver Developmental Screening Test II (DDST-II) and the Early Language Milestone Scale (ELMS)...
November 2016: CoDAS
https://www.readbyqxmd.com/read/27976553/screening-5-and-6-year-old-children-starting-primary-school-for-development-and-language
#6
Deniz Yılmaz, Nuray Bayar-Muluk, Birgül Bayoğlu, Aysun İdil, Banu Anlar
Beginning school is an important milestone for children. Children's readiness for school involves cognitive, physical, and emotional development. Certain school programs allow children to start first grade after 66 months of age, together with 72 month-old children. In order to estimate school readiness, we screened children before starting first grade and compared their school performance according to their age and socio-demographic characteristics. Marmara School Readiness, Denver II developmental screening, and language assessment tests were applied...
2016: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27910128/predictors-of-developmental-surveillance-completion-at-six-months-of-age-in-south-western-sydney
#7
B J Overs, S Woolfenden, K Williams, B Jalaludin, E L Axelsson, C Dissanayake, J Descallar, S Harvey, D Beasley, E Murphy, V Eapen
BACKGROUND: While developmental surveillance programs promote early identification of child developmental problems, evidence has indicated suboptimal uptake. This study aimed to identify predictors of developmental surveillance completion at 6 months postpartum. METHODS: Questionnaires were administered to the parents of 510 infants who were born in south western Sydney, Australia over a 22-month period. Attendance for developmental screening and completion of the Parents' Evaluation of Developmental Status (PEDS) at 6 months postpartum were modelled separately using multivariable logistic regression...
December 1, 2016: Child: Care, Health and Development
https://www.readbyqxmd.com/read/27889718/parents-evaluation-of-developmental-status-peds-in-screening-for-developmental-delay-in-thai-children-aged-18-30-months
#8
Pornchanok Wantanakorn, Khemsuang Sawangworachart, Rawiwan Roongpraiwan, Jariya Chuthapisith
The PEDS-Thai is a developmental screening tool. We studied its diagnostic performance among 137 Thai children (48.9%) aged 18-30 month. It had a sensitivity of 92.8% and a specificity of 49.2%. The positive and negative likelihood ratios were 1.82 and 0.14 when compared with clinical diagnosis and diagnostic tool, the Mullen Scales of Early Learning.
December 15, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27777218/a-multimedia-child-developmental-screening-checklist-design-and-validation
#9
Hsin-Yi Kathy Cheng, Li-Ying Chen, Chih-Hsiu Cheng, Yan-Ying Ju, Chia-Ling Chen, Kevin C Tseng
BACKGROUND: Identifying disability early in life confers long-term benefits for children. The Taipei City Child Development Screening tool, second version (Taipei II) provides checklists for 13 child age groups from 4 months to 6 years. However, the usability of a text-based screening tool largely depends on the literacy level and logical reasoning ability of the caregivers, as well as language barriers caused by increasing numbers of immigrants. OBJECTIVE: The objectives of this study were to (1) design and develop a Web-based multimedia version of the current Taipei II developmental screening tool, and (2) investigate the measurement equivalence of this multimedia version to the original paper-based version...
October 24, 2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/27746006/-predictive-value-of-ages-stages-questionnaires-for-cognitive-performance-at-early-years-of-schooling
#10
Luisa Schonhaut B, Marcela Pérez R, Ana María Castilla F, Sonia Castro M, Patricia Salinas A, Iván Armijo R
INTRODUCTION: The Ages and Stages questionnaires (ASQ) has been recently validated in our country for developmental screening. The objective of this study is evaluate the validity of ASQ to predict low cognitive performance in the early years of schooling. PATIENTS AND METHOD: Diagnostic test studies conducted on a sample of children of medium-high socioeconomic level were evaluated using ASQ at least once at 8, 18 and/or 30 months old, and later, between 6 and 9 years old, reevaluated using the Wechsler Intelligence Scale for Children-third edition (WISC-III)...
October 13, 2016: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/27699768/cross-cultural-validity-of-standardized-motor-development-screening-and-assessment-tools-a-systematic-review
#11
REVIEW
Bianca Mendonça, Barbara Sargent, Linda Fetters
AIM: To investigate whether standardized motor development screening and assessment tools that are used to evaluate motor abilities of children aged 0 to 2 years are valid in cultures other than those in which the normative sample was established. METHOD: This was a systematic review in which six databases were searched. Studies were selected based on inclusion/exclusion criteria and appraised for evidence level and quality. Study variables were extracted. RESULTS: Twenty-three studies representing six motor development screening and assessment tools in 16 cultural contexts met the inclusion criteria: Alberta Infant Motor Scale (n=7), Ages and Stages Questionnaire, 3rd edition (n=2), Bayley Scales of Infant and Toddler Development, 3rd edition (n=8), Denver Developmental Screening Test, 2nd edition (n=4), Harris Infant Neuromotor Test (n=1), and Peabody Developmental Motor Scales, 2nd edition (n=1)...
December 2016: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/27697304/neurodevelopmental-outcome-of-term-infants-with-perinatal-asphyxia-with-hypoxic-ischemic-encephalopathy-stage-ii
#12
Sudhir Adhikari, Kalipatnam Seshagiri Rao
BACKGROUND: Perinatal asphyxia with hypoxic ischemic encephalopathy (HIE) causes significant mortality and morbidity in developing countries. There is limited information about long term neurodevelopmental outcome of infants with neonatal encephalopathy. METHODS: Term infants with the diagnosis of perinatal asphyxia were followed up in neurodevelopmental clinics of Manipal Teaching hospital, Nepal. Study design was prospective mixed longitudinal study. Prematurity, major congenital malformations, other intracranial pathology, birth weight <2500g and chromosomal abnormalities were excluded...
February 2017: Brain & Development
https://www.readbyqxmd.com/read/27642617/data-relating-to-early-child-development-in-the-avon-longitudinal-study-of-parents-and-children-alspac-their-relationship-with-prenatal-blood-mercury-and-stratification-by-fish-consumption
#13
Yasmin Iles-Caven, Jean Golding, Steven Gregory, Alan Emond, Caroline M Taylor
As part of the Avon Longitudinal Study of Parents and Children (ALSPAC), measures of early child development were collected using both hands-on expert assessment (on a random 10% sub-sample) by trained psychologists at 18 months using the Griffiths Mental Development Scales (Extended 0-8 years) and from detailed questionnaires completed by the study mothers on the whole cohort using assessments based on the Denver Developmental Screening Test. The development determined by the psychologists on the 10% subsample showed a correlation of 0...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27557465/assessment-of-deformational-plagiocephaly-severity-and-neonatal-developmental-delay
#14
Stefani C Fontana, Debora Daniels, Thomas Greaves, Niaman Nazir, Jeff Searl, Brian T Andrews
Deformational plagiocephaly (DP) in infants has been associated with developmental delay that can last until adolescence. Despite this association and a 5-fold increase in incidence of DP over the past 2 decades, there are currently no guidelines regarding screening for developmental delay or identification of which infants with DP are at the greatest risk of delay. A prospective, nonrandomized study was performed. Infants diagnosed with DP who had no prior intervention were eligible for enrollment. Cranial deformity was measured by cross-cranial measurements using calipers, and developmental delay was measured using the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III)...
August 24, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27548634/concurrent-validity-and-feasibility-of-short-tests-currently-used-to-measure-early-childhood-development-in-large-scale-studies
#15
Marta Rubio-Codina, M Caridad Araujo, Orazio Attanasio, Pablo Muñoz, Sally Grantham-McGregor
In low- and middle-income countries (LIMCs), measuring early childhood development (ECD) with standard tests in large scale surveys and evaluations of interventions is difficult and expensive. Multi-dimensional screeners and single-domain tests ('short tests') are frequently used as alternatives. However, their validity in these circumstances is unknown. We examined the feasibility, reliability, and concurrent validity of three multi-dimensional screeners (Ages and Stages Questionnaires (ASQ-3), Denver Developmental Screening Test (Denver-II), Battelle Developmental Inventory screener (BDI-2)) and two single-domain tests (MacArthur-Bates Short-Forms (SFI and SFII), WHO Motor Milestones (WHO-Motor)) in 1,311 children 6-42 months in Bogota, Colombia...
2016: PloS One
https://www.readbyqxmd.com/read/27544061/validation-of-a-culturally-adapted-developmental-screening-tool-for-australian-aboriginal-children-early-findings-and-next-steps
#16
Samantha Simpson, Anita D'Aprano, Collette Tayler, Siek Toon Khoo, Roxanne Highfold
BACKGROUND: Early detection of developmental problems is important for facilitating access to targeted intervention and maximising its positive effects. The later problems are identified, the more likely that they will become increasingly difficult to ameliorate. Standardised developmental screening tools are known to improve detection rates of developmental problems compared to clinical judgement alone and are widely recommended for use with all children. The Ages and Stages Questionnaire (ASQ-3) is a tool that is widely used in Australia...
December 2016: Early Human Development
https://www.readbyqxmd.com/read/27536852/early-developmental-outcomes-predicted-by-gestational-age-from-35-to-41weeks
#17
Gwenden Dueker, Jing Chen, Candace Cowling, Brian Haskin
BACKGROUND: Recent studies have indicated that children born only a few weeks earlier than their due date experience more health and cognitive problems than previously realized. AIMS: Our study investigated whether gestational age (GA) at birth (35-41weeks) predicted developmental outcomes at 8, 12, 20, or 24months of age. STUDY DESIGN: Archival records of developmental screening scores collected between 2006 and 2012 were analyzed using negative binomial and logistic regressions models...
December 2016: Early Human Development
https://www.readbyqxmd.com/read/27534884/challenges-in-monitoring-the-development-of-young-children-in-remote-aboriginal-health-services-clinical-audit-findings-and-recommendations-for-improving-practice
#18
Anita D'Aprano, Sven Silburn, Vanessa Johnston, Ross Bailie, Fiona Mensah, Frank Oberklaid, Gary Robinson
INTRODUCTION: Early detection of developmental difficulties is universally considered a necessary public health measure, with routine developmental monitoring an important function of primary healthcare services. This study aimed to describe the developmental monitoring practice in two remote Australian Aboriginal primary healthcare services and to identify gaps in the delivery of developmental monitoring services. METHODS: A cross-sectional baseline medical record audit of all resident children aged less than 5 years in two remote Aboriginal health centres in the Northern Territory (NT) in Australia was undertaken between December 2010 and November 2011...
July 2016: Rural and Remote Health
https://www.readbyqxmd.com/read/27527798/developmental-screening-of-refugees-a-qualitative-study
#19
Abigail L H Kroening, Jessica A Moore, Therese R Welch, Jill S Halterman, Susan L Hyman
BACKGROUND AND OBJECTIVES: Refugee children are at high developmental risk due to dislocation and deprivation. Standardized developmental screening in this diverse population is challenging. We used the Health Belief Model to guide key-informant interviews and focus groups with medical interpreters, health care providers, community collaborators, and refugee parents to explore key elements needed for developmental screening. Cultural and community-specific values and practices related to child development and barriers and facilitators to screening were examined...
September 2016: Pediatrics
https://www.readbyqxmd.com/read/27453562/alterations-in-biochemical-markers-due-to-mercury-hg-exposure-and-its-influence-on-infant-s-neurodevelopment
#20
Iman Al-Saleh, Rola Elkhatib, Reem Al-Rouqi, Mai Abduljabbar, Chafica Eltabache, Tahreer Al-Rajudi, Michael Nester
This study examined the role of oxidative stress due to mercury (Hg) exposure on infant's neurodevelopmental performance. A total of 944 healthy Saudi mothers and their respective infants (aged 3-12 months) were recruited from 57 Primary Health Care Centers in Riyadh City. Total mercury (Hg) was measured in mothers and infants urine and hair samples, as well as mother's blood and breast milk. Methylmercury (MeHg) was determined in the mothers and infants' hair and mother's blood. Urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG), malondialdehyde (MDA), and porphyrins were used to assess oxidative stress...
July 2, 2016: International Journal of Hygiene and Environmental Health
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