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https://www.readbyqxmd.com/read/29778018/phytochemistry-and-pharmacology-of-anti-depressant-medicinal-plants-a-review
#1
REVIEW
Jeanette Martins, Brijesh S
Stress renders an individual to experience mental pressure and exhaustion which brings about feelings of anxiety, depression, anger and/or other negative emotions. Depression affects a person's state of mind, behaviour, health and is often associated with suicide. The use of anti-depressant drugs as therapeutic agents is associated with symptoms such as, delayed onset of action, side-effects, drug-drug and dietary interactions, sexual dysfunction, cardiac toxicity, etc. Thus, there is need to target these issues and improve current treatment options...
May 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29767911/analysis-of-the-concept-of-powerlessness-in-individuals-with-stroke
#2
Renan Alves Silva, Álissan Karine Lima Martins, Natália Barreto de Castro, Anna Virgínia Viana, Howard Karl Butcher, Viviane Martins da Silva
OBJECTIVES: To identify and analyze the concept of the powerlessness in individuals with stroke, according to the NANDA-I Taxonomy. METHODS: Concept analysis from online access of four databases using the descriptors: impotence; helplessness, learned; Stroke, depression in languages: Portuguese, English and Spanish. RESULTS: The critical attributes of the feeling of powerlessness are: fragility, helplessness, lack of control, and power to achieve the proposed results for recovery and adaptation...
October 2017: Investigación y Educación en Enfermería
https://www.readbyqxmd.com/read/29745679/sources-of-perceived-responsiveness-in-family-relationships
#3
William L Cook, Marie Dezangré, Jan De Mol
Perceived responsiveness has become one of the most important constructs in the relationship sciences. It is central to the development of a secure attachment style, the experience of social support, an internal locus of control, and the sense of control in close relationships. Conversely, an unresponsive environment is associated with learned helplessness and depression. Viewed through the lens of the social relations model (SRM), perceived responsiveness in family relationships could have multiple sources: the perceiver; the target or partner; the perceiver-target relationship; and the family group...
May 10, 2018: Journal of Family Psychology: JFP
https://www.readbyqxmd.com/read/29736116/providing-palliative-care-in-rural-nepal-perceptions-of-mid-level-health-workers
#4
Rajesh N Gongal, Shambhu Kumar Upadhyay, Kedar Prasad Baral, Max Watson, George W Kernohan
Introduction: Nepal is beginning to develop palliative care services across the country. Most people live in rural areas, where the Mid-Level Health Workers (MHWs) are the major service providers. Their views on providing palliative care are most important in determining how the service is organized and developed. Aim: This study aims to ascertain the perceptions of MHWs about palliative care in their local community, to inform service development. Methods: A qualitative descriptive design, using focus group discussions, was used to collect data from a rural district of Makwanpur, 1 of the 75 districts of Nepal...
April 2018: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29704202/role-of-hpa-and-the-hpg-axis-interaction-in-testosterone-mediated-learned-helpless-behavior
#5
Birgit Ludwig, Bhaskar Roy, Yogesh Dwivedi
Affective disorders show sex-specific differences in prevalence, symptoms, and complications. One hypothesis for this discrepancy is the interaction between the hypothalamic-pituitary-adrenal (HPA) axis and hypothalamic-pituitary-gonadal (HPG) axis. The present study investigates the influence of androgen on the behavioral phenotype and explores how it interacts with HPA axis genes. Gonadectomized (GDX) and GDX rats treated with testosterone propionate (T) were tested for learned helplessness (LH) behavior and compared with tested controls (TC)...
April 28, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29698707/distinct-characteristics-of-hippocampal-pathogenic-t-h-17-cells-in-a-mouse-model-of-depression
#6
Eléonore Beurel, Jeffrey Lowell, Richard Jope
Increasing evidence indicates that multiple actions of the immune system are closely intertwined with the development of depression and subsequent recovery processes. One of these interactions is substantial evidence that the TH 17 subtype of CD4+ T cells promotes susceptibility to depression-like behaviors in rodents. Comparing subtypes of CD4+ T cells, we found that administration of TH 17 cells, but not TH 1 cells or TREGS , promoted susceptibility to learned-helplessness depressive-like behavior and accumulated in the hippocampus of learned helpless mice...
April 23, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29667127/bilateral-olfactory-mucosa-damage-induces-the-disappearance-of-olfactory-glomerulus-and-reduces-the-expression-of-extrasynaptic-%C3%AE-5gaba-a-rs-in-the-hippocampus-in-early-postnatal-sprague-dawley-rats
#7
Xiaomin Zheng, Liang Liang, Changchun Hei, Wenjuan Yang, Tingyuan Zhang, Kai Wu, Yi Qin, Qing Chang
Chloroform-induced olfactory mucosal degeneration has been reported in adult rats following gavage. We used fixed-point chloroform infusions on different postnatal days (PNDs) to investigate the effects of early olfactory bilateral deprivation on the main olfactory bulbs in Sprague Dawley rats. The experimental groups included rats infused with chloroform (5 μl) or saline (sham, 5 μl) on PNDs 3 and 8, and rats not receiving infusions (control) (n = 6 in all groups). Rats receiving chloroform on PND 3 showed significant hypoevolutism when compared to those in other groups (P < 0...
April 17, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29620593/evaluation-of-learned-helplessness-perceived-self-efficacy-and-functional-capacity-in-patients-with-fibromyalgia-and-rheumatoid-arthritis
#8
Sebastián Moyano, Marina Scolnik, Facundo Vergara, María Victoria García, Mirtha Rosa Sabelli, Javier Eduardo Rosa, Luis José Catoggio, Enrique Roberto Soriano
OBJECTIVES: The aims of this study were to compare learned helplessness (LH) and perceived self-efficacy (SE) in patients with fibromyalgia (FM) and rheumatoid arthritis (RA) and to assess their correlation with functional disability, level of perceived pain, and fatigue. METHODS: This multicenter, cross-sectional study included consecutive patients (aged ≥18 years) with RA, according to the 2010 American College of Rheumatology/European League Against Rheumatism criteria, and FM, according to 2010 American College of Rheumatology criteria...
March 19, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29554264/isoflurane-but-not-halothane-prevents-and-reverses-helpless-behavior-a-role-for-eeg-burst-suppression
#9
P Leon Brown, Panos Zanos, Leiming Wang, Greg I Elmer, Todd D Gould, Paul D Shepard
Background: The volatile anesthetic isoflurane may exert a rapid and long-lasting antidepressant effect in patients with medication-resistant depression. The mechanism underlying the putative therapeutic actions of the anesthetic have been attributed to its ability to elicit cortical burst suppression, a distinct EEG pattern with features resembling the characteristic changes that occur following electroconvulsive therapy. It is currently unknown whether the antidepressant actions of isoflurane are shared by anesthetics that do not elicit cortical burst suppression...
March 15, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29539650/-class-climate-academic-well-being-and-self-rated-health-among-school-children-in-germany-findings-of-the-national-educational-panel-study-neps
#10
Katharina Rathmann, Max Herke, Klaus Hurrelmann, Matthias Richter
OBJECTIVES: The aim of this study was to examine the associations between features of class climate and school wellbeing, based on self-rated health and reports of absence from school due to illness among adolescents in secondary schools, by using data from the German National Educational Panel Study (NEPS). METHODS: Data was obtained from the National Educational Panel Study (NEPS). The sample includes (n=7,348) seventh grade students in regular schools (Starting Cohort 3, Wave 3, 2012)...
March 14, 2018: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29529039/technology-attributions-and-emotions-in-post-secondary-education-an-application-of-weiner-s-attribution-theory-to-academic-computing-problems
#11
Rebecca Maymon, Nathan C Hall, Thomas Goetz, Andrew Chiarella, Sonia Rahimi
As technology becomes increasingly integrated with education, research on the relationships between students' computing-related emotions and motivation following technological difficulties is critical to improving learning experiences. Following from Weiner's (2010) attribution theory of achievement motivation, the present research examined relationships between causal attributions and emotions concerning academic computing difficulties in two studies. Study samples consisted of North American university students enrolled in both traditional and online universities (total N = 559) who responded to either hypothetical scenarios or experimental manipulations involving technological challenges experienced in academic settings...
2018: PloS One
https://www.readbyqxmd.com/read/29501509/enhanced-cholinergic-tone-during-the-stress-induce-a-depressive-like-state-in-mice
#12
Sara S Fernandes, André P Koth, Gustavo M Parfitt, Marcos F Cordeiro, Carolina S Peixoto, Andréa Soubhia, Fernanda P Moreira, Carolina D Wiener, Jean P Oses, Erikson Kaszubowski, Daniela M Barros
Major depressive disorder has a heterogeneous etiology, since it arises from the interaction of multiple factors and different pathophysiological mechanisms are involved in the symptomatology. This study aimed to investigate the role of the cholinergic system in the susceptibility to stress and, consequently, in the depression-like behavior. C57BL/6 mice were treated with Physostigmine (PHYS), an acetylcholinesterase (AChE) inhibitor, and were submitted to the social defeat stress. For the behavioral evaluation of the locomotor activity, anxiety-like and depression-like behaviors the open field, elevated plus maze, sucrose preference, social interaction and forced swim were used...
March 1, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29471082/anhedonic-behavior-and-%C3%AE-amino-butyric-acid-during-a-sensitive-period-in-female-rats-exposed-to-early-adversity
#13
Jodi L Lukkes, Shirisha Meda, Kevin J Norman, Susan L Andersen
Early life adversity increases depressive behavior that emerges during adolescence. Sensitive periods have been associated with fewer GABAergic interneurons, especially parvalbumin (PV), brain derived growth factor, and its receptor, TrkB. Here, maternal separation (MS) and social isolation (ISO) were used to establish a sensitive period for anhedonic depression using the learned helplessness (LH) paradigm. Female Sprague-Dawley rat pups underwent MS for 4-h/day or received typical care (CON) between postnatal days 2-20; for the ISO condition, separate cohorts were individually housed between days 20-40 or served as controls (CON2)...
May 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29452218/tnf%C3%AE-disrupts-blood-brain-barrier-integrity-to-maintain-prolonged-depressive-like-behavior-in-mice
#14
Yuyan Cheng, Sachi Desse, Ana Martinez, Ryan J Worthen, Richard S Jope, Eleonore Beurel
Recovery from major depressive disorder is difficult, particularly in patients who are refractory to antidepressant treatments. To examine factors that regulate recovery, we developed a prolonged learned helplessness depression model in mice. After the induction of learned helplessness, mice were separated into groups that recovered or did not recover within 4 weeks. Comparisons were made between groups in hippocampal proteins, inflammatory cytokines, and blood brain barrier (BBB) permeability. Compared with mice that recovered and control mice, non-recovered mice displaying prolonged learned helplessness had greater hippocampal activation of glycogen synthase kinase-3 (GSK3), higher levels of tumor necrosis factor-α (TNFα), interleukin-17A, and interleukin-23, increased permeability of the blood brain barrier (BBB), and lower levels of the BBB tight junction proteins occludin, ZO1, and claudin-5...
March 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29444084/attributional-style-and-depressive-symptoms-in-a-male-prison-sample
#15
Danny J O'Sullivan, Maura E O'Sullivan, Brendan D O'Connell, Ken O'Reilly, Kiran M Sarma
The reformulated learned helplessness model proposes that people who tend to make internal, stable, and global attributions in response to uncontrollable aversive events are more likely to develop depression. The present study sought to investigate the nature of the relationship between attributional style and depression in a male prison sample. One hundred and one adult male prisoners from four medium security prisons in Ireland completed the Attributional Style Questionnaire and measures of depression (BDI-II) and anxiety (BAI)...
2018: PloS One
https://www.readbyqxmd.com/read/29429848/learned-helplessness-in-doctors-with-dyslexia-time-for-a-change-in-discourse
#16
EDITORIAL
Sebastian C K Shaw
No abstract text is available yet for this article.
February 6, 2018: Nurse Education in Practice
https://www.readbyqxmd.com/read/29390069/long-non-coding-rna-associated-transcriptomic-changes-in-resiliency-or-susceptibility-to-depression-and-response-to-antidepressant-treatment
#17
Bhaskar Roy, Qingzhong Wang, Yogesh Dwivedi
Background: Recent emergence of long non-coding RNAs (lncRNAs) in regulating gene expression and thereby modulating physiological functions in brain has manifested their possible role in psychiatric disorders. In this study, the roles of lncRNAs in susceptibility and resiliency to develop stress-induced depression and their response to antidepressant treatment were examined. Methods: Microarray based transcriptome-wide changes in lncRNAs was determined in hippocampus of male Holtzman rats who showed susceptibility (learned helpless; LH) or resiliency (non-learned helpless; NLH) to develop depression...
January 30, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29378290/antidepressant-administration-modulates-stress-induced-dna-methylation-and-dna-methyltransferase-expression-in-rat-prefrontal-cortex-and-hippocampus
#18
Amanda J Sales, Sâmia R L Joca
Stress and antidepressant treatment can modulate DNA methylation in promoter region of genes related to neuroplasticity and mood regulation, thus implicating this epigenetic mechanism in depression neurobiology and treatment. Accordingly, systemic administration of DNA methyltransferase (DNMT) inhibitors induces antidepressant-like effects in rodents. DNA methylation is conveyed by DNMT 1, 3a and 3b isoforms, which are differentially expressed in the brain. In order to investigate if the behavioral effects of antidepressants could be associated with changes in DNA methylation and DNMT expression, we investigated the effects induced by acute and repeated antidepressant treatment on DNA methylation and DNMT expression (1, 3a and 3b isoforms) in different brain regions of rats exposed to a stress model of depression, the learned helplessness (LH)...
May 2, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29362511/neuropsychiatric-phenotypes-produced-by-gaba-reduction-in-mouse-cortex-and-hippocampus
#19
Stefan M Kolata, Kazuhito Nakao, Vivek Jeevakumar, Emily L Farmer-Alroth, Yuko Fujita, Aundrea F Bartley, Sunny Zhihong Jiang, Gregory R Rompala, Robert E Sorge, Dennisse V Jimenez, Keri Martinowich, Yolanda Mateo, Kenji Hashimoto, Lynn E Dobrunz, Kazu Nakazawa
Whereas cortical GAD67 reduction and subsequent GABA level decrease are consistently observed in schizophrenia and depression, it remains unclear how these GABAergic abnormalities contribute to specific symptoms. We modeled cortical GAD67 reduction in mice, in which the Gad1 gene is genetically ablated from ~50% of cortical and hippocampal interneurons. Mutant mice showed a reduction of tissue GABA in the hippocampus and cortex including mPFC, and exhibited a cluster of effort-based behavior deficits including decreased home-cage wheel running and increased immobility in both tail suspension and forced swim tests...
May 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29320976/the-mediational-role-of-helplessness-in-psychological-outcomes-in-systemic-lupus-erythematosus
#20
S D Mills, D Azizoddin, S Gholizadeh, G Z Racaza, P M Nicassio
Objective Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can result in disability and psychological distress. Although pain has been associated with depressive symptomatology and stress in SLE, a paucity of theoretical models have been used to explain the relationship between pain and psychological distress in this population. Thus, the present study examined helplessness as a mediator of the relationship between pain and psychological distress among patients with SLE. Methods Multiple mediation analysis was used to examine the hypothesis that learned helplessness mediates the relationship between pain and symptoms of anxiety, depression, and stress in a sample of patients with SLE ( N = 136) receiving medical care at Cedars Sinai Medical Center...
January 1, 2018: Lupus
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