keyword
MENU ▼
Read by QxMD icon Read
search

learned helplessness

keyword
https://www.readbyqxmd.com/read/29320976/the-mediational-role-of-helplessness-in-psychological-outcomes-in-systemic-lupus-erythematosus
#1
S D Mills, D Azizoddin, S Gholizadeh, G Z Racaza, P M Nicassio
Objective Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can result in disability and psychological distress. Although pain has been associated with depressive symptomatology and stress in SLE, a paucity of theoretical models have been used to explain the relationship between pain and psychological distress in this population. Thus, the present study examined helplessness as a mediator of the relationship between pain and psychological distress among patients with SLE. Methods Multiple mediation analysis was used to examine the hypothesis that learned helplessness mediates the relationship between pain and symptoms of anxiety, depression, and stress in a sample of patients with SLE ( N = 136) receiving medical care at Cedars Sinai Medical Center...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29317595/hippocampal-metabolic-differences-implicate-distinctions-between-physical-and-psychological-stress-in-four-rat-models-of-depression
#2
Lanxiang Liu, Xinyu Zhou, Yuqing Zhang, Juncai Pu, Lining Yang, Shuai Yuan, Libo Zhao, Chanjun Zhou, Hanping Zhang, Peng Xie
Major depressive disorder (MDD) is a heterogeneous and multi-factorial disorder, and the underlying molecular mechanisms remain largely unknown. However, many studies have indicated that the molecular mechanisms underlying depression in response to different stress may differ. After screening, 28-30 rats were included in each model of depression (chronic unpredictable mild stress (CUMS); learned helplessness (LH); chronic restraint stress (CRS); or social defeat (SD)). Non-targeted gas chromatography-mass spectrometry was used to profile the metabolic changes in the hippocampus...
January 10, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29294690/mediators-and-moderators-of-the-association-between-stalking-victimization-and-psychological-distress
#3
Connor R Fais, Catherine J Lutz-Zois, Jackson A Goodnight
The current study aims to understand mediators and moderators of the relationship between stalking victimization and depression. Based on the reformulated learned helplessness theory, which emphasizes the role of internal, global, and stable attributions for negative events in the development of depression, we predicted that the association between stalking victimization and depression would be mediated by attributions for the stalking and characterological self-blame. We predicted that the association between stalking victimization and helplessness attributions or characterological self-blame, in turn, would be moderated by gender, sex-role identity, and length of stalking...
March 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29230479/effects-of-a-hybrid-education-programme-for-korean-mothers-of-children-with-atopic-dermatitis
#4
Je-Bog Yoo, Jennie C de Gagne, Seung-Hyeon S Jeong, Chan-Woo Jeong
Atopic dermatitis (AD), a common childhood skin disorder, can limit a child's learning and physical activities. South Korean mothers, as primary caregivers, experience anxiety and helplessness when caring for their ill children. The aim of this study was to develop an AD education programme (consisting of a face-to-face session followed by 8 online sessions) and evaluate its effects on anxiety, caregiving efficacy and caregiving behaviour among mothers of children with AD. Twenty mothers of patients with AD treated in a South Korean hospital received 1 on-site session and 8 weekly online modules...
December 12, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29219903/nursing-staff-perceptions-of-fall-risk-the-emergence-of-learned-helplessness-as-a-theme
#5
Terri Lea Gibson, Susan L Lloyd
Nurses and unlicensed assistive personnel on 2 medical-surgical units were asked about their perceptions regarding patient falls. Their responses reflect learned helplessness and a lack of nurse empowerment that are relevant findings as nurse executives work to decrease patient falls.
January 2018: Journal of Nursing Administration
https://www.readbyqxmd.com/read/29180805/a-fast-approach-to-detect-gene-gene-synergy
#6
Pengwei Xing, Yuan Chen, Jun Gao, Lianyang Bai, Zheming Yuan
Selecting informative genes, including individually discriminant genes and synergic genes, from expression data has been useful for medical diagnosis and prognosis. Detecting synergic genes is more difficult than selecting individually discriminant genes. Several efforts have recently been made to detect gene-gene synergies, such as dendrogram-based I(X 1; X 2; Y) (mutual information), doublets (gene pairs) and MIC(X 1; X 2; Y) based on the maximal information coefficient. It is unclear whether dendrogram-based I(X 1; X 2; Y) and doublets can capture synergies efficiently...
November 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29180675/protein-kinase-m%C3%AE-in-medial-prefrontal-cortex-mediates-depressive-like-behavior-and-antidepressant-response
#7
W Yan, J-F Liu, Y Han, W Zhang, Y-X Luo, Y-X Xue, W-L Zhu, C Yang, W-H Chen, H-L Guo, Y-N Ma, K Yuan, J-S Wang, J Shi, L Lu
Neuronal atrophy and alterations of synaptic structure and function in the medial prefrontal cortex (mPFC) have been implicated in the pathogenesis of depression, but the underlying molecular mechanisms are largely unknown. The protein kinase Mζ (PKMζ), a brain-specific atypical protein kinase C isoform, is important for maintaining long-term potentiation and storing memory. In the present study, we explored the role of PKMζ in mPFC in two rat models of depression, chronic unpredictable stress (CUS) and learned helplessness...
November 28, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29174736/protein-kinase-a-mediates-scopolamine-induced-mtor-activation-and-an-antidepressant-response
#8
Jianyang Dong, Qinji Zhou, Zhisheng Wei, Shi Yan, Fangfang Sun, Xiang Cai
BACKGROUND: Clinical reports have shown that scopolamine produces a rapid (3-4 d) and potent anti-depressive response without severe adverse effects. Animal experiments have proven that scopolamine induces mTOR pathway activation in an AMPAR dependent manner. The present study aimed to determine the role of PKA in scopolamine-induced potentiation of AMPAR, as well as in mTOR pathway activation and rapid antidepressant effects. METHODS: We utilized electrophysiological recording, Western blotting, and behavior tests to examine the effects of scopolamine, the selective M2 cholinergic receptor antagonist methoctramine, and H89, a PKA specific inhibitor on AMPAR potentiation, mTOR pathway activation, and behavioral responses in a rat depression model of learned helplessness...
November 13, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29162061/medical-student-attitudes-and-educational-interventions-to-prevent-neurophobia-a-longitudinal-study
#9
Lisa Shiels, Pratish Majmundar, Aleksander Zywot, John Sobotka, Christine S M Lau, Tuula O Jalonen
BACKGROUND: With an aging American population, the burden of neurologic disease is intensifying and the decline in neurology residents and practicing neurologists is leaving these patients helpless and unable to find care. 'Neurophobia', a chronic illness that begins early in medical school, has been identified as a cause for the low number of neurology residents. METHODS: A longitudinal study surveyed medical students at the beginning of their first year (M1) and then again at the beginning of their second year (M2)...
November 21, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29155993/lack-of-antidepressant-effects-of-2r-6r-hydroxynorketamine-in-a-rat-learned-helplessness-model-comparison-with-r-ketamine
#10
Yukihiko Shirayama, Kenji Hashimoto
Background: (R)-Ketamine exhibits rapid and sustained antidepressant effects in animal models of depression. It is stereoselectively metabolized to (R)-norketamine, and subsequently to (2R,6R)-hydroxynorketamine (HNK) in the liver. The metabolism of ketamine to HNK was recently demonstrated to be essential for ketamine's antidepressant actions. However, no study has compared the antidepressant effects of these three compounds in animal models of depression. Methods: The effects of a single intraperitoneal injection of (R)-ketamine, (R)-norketamine, and (2R,6R)-HNK in a rat learned helplessness (LH) model were examined...
November 15, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29151391/repeated-treatment-with-nitric-oxide-synthase-inhibitor-attenuates-learned-helplessness-development-in-rats-and-increases-hippocampal-bdnf-expression
#11
Laura Alves Stanquini, Caroline Biojone, Francisco Silveira Guimarães, Sâmia Regiane Joca
BACKGROUND: Nitric oxide synthase (NOS) inhibitors induce antidepressant-like effects in animal models sensitive to acute drug treatment such as the forced swimming test. However, it is not yet clear if repeated treatment with these drugs is required to induce antidepressant-like effects in preclinical models. OBJECTIVE: The aim of this study was to test the effect induced by acute or repeated (7 days) treatment with 7-nitroindazole (7-NI), a preferential inhibitor of neuronal NOS, in rats submitted to the learned helplessness (LH) model...
November 20, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29132340/what-do-japanese-residents-learn-from-treating-dying-patients-the-implications-for-training-in-end-of-life-care
#12
Kazuko Arai, Takuya Saiki, Rintaro Imafuku, Chihiro Kawakami, Kazuhiko Fujisaki, Yasuyuki Suzuki
BACKGROUND: How medical residents' experiences with care for dying patients affect their emotional well-being, their learning outcomes, and the formation of their professional identities is not fully understood. We examine residents' emotional states and learning occurring during the provision of care to dying patients and specifically discuss the impact of providing end-of-life (EOL) care on professional identity formation. METHODS: Semi-structured interviews were conducted with 13 residents who had graduated in the last 3 to 5 years...
November 13, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29119264/keap1-nrf2-signaling-pathway-confers-resilience-versus-susceptibility-to-inescapable-electric-stress
#13
Ji-Chun Zhang, Wei Yao, Chao Dong, Mei Han, Yukihiko Shirayama, Kenji Hashimoto
The transcription factor Keap1-Nrf2 signaling plays a key role in the oxidative stress which is involved in psychiatric disorders. In the learned helplessness (LH) paradigm, protein levels of Keap1 and Nrf2 in the prefrontal cortex and dentate gyrus of hippocampus from LH (susceptible) rats were lower than control and non-LH (resilience) rats. Furthermore, protein expressions of Keap1 and Nrf2 in the parietal cortex from major depressive disorder, schizophrenia, and bipolar disorder were lower than controls...
November 8, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29075536/neural-plasticity-associated-with-hippocampal-pka-creb-and-nmda-signaling-is-involved-in-the-antidepressant-effect-of-repeated-low-dose-of-yueju-pill-on-chronic-mouse-model-of-learned-helplessness
#14
Zhilu Zou, Yin Chen, Qinqin Shen, Xiaoyan Guo, Yuxuan Zhang, Gang Chen
Yueju pill is a traditional Chinese medicine formulated to treat syndromes of mood disorders. Here, we investigated the therapeutic effect of repeated low dose of Yueju in the animal model mimicking clinical long-term depression condition and the role of neural plasticity associated with PKA- (protein kinase A-) CREB (cAMP response element binding protein) and NMDA (N-methyl-D-aspartate) signaling. We showed that a single low dose of Yueju demonstrated antidepressant effects in tests of tail suspension, forced swim, and novelty-suppressed feeding...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28957945/rough-and-tumble-play-induces-resilience-to-stress-in-rats
#15
Jeffrey Burgdorf, Roger A Kroes, Joseph R Moskal
Positive emotions have been shown to induce resilience to stress in humans, as well as increase cognitive abilities (learning, memory, and problem solving) and improve overall health. In rats, frequency modulated 50-kHz ultrasonic vocalizations (hedonic 50 kHz) reflect a positive affective state and are best elicited by rough-and-tumble play. A well-established rat chronic unpredictable stress paradigm was used to produce a robust and long-lasting decrease in positive affect, increase in negative affect, and learned helplessness in Sprague-Dawley rats...
December 6, 2017: Neuroreport
https://www.readbyqxmd.com/read/28867895/estrous-cycle-phase-dependent-changes-in-anxiety-and-depression-like-profiles-in-the-late-adolescent-wistar-kyoto-rat
#16
Deepthi D'Souza, Monika Sadananda
BACKGROUND: Depression often manifests during adolescence when the development and networking of social and emotional brain areas is being influenced by hormones. The Wistar Kyoto (WKY) rat has been proposed as an animal model of adolescent depression with various face, construct, and predictive validities for clinical depression having been established. PURPOSE: The influence of the estrous cycle on anxiety- and depression-like behaviors in female adolescents may be tested out further using this model...
July 2017: Annals of Neurosciences
https://www.readbyqxmd.com/read/28844005/synaptic-potentiation-mediated-by-l-type-voltage-dependent-calcium-channels-mediates-the-antidepressive-effects-of-lateral-habenula-stimulation
#17
Qinji Zhou, Jianyang Dong, Ting Xu, Xiang Cai
Although deep-brain stimulation (DBS) of the lateral habenula (LHb) has been successfully applied to treatment-resistant depression for years, the mechanism is still unclear. Previous researches have demonstrated that LHb-DBS elevates brain monoamine neurotransmitters. However, these changes do not account for the treatment efficacy on treatment-resistant depression, or the rapid behavioral effects in rats; the evidence suggests that altered synaptic potentiation may contribute to the treatment effects. We applied LHb-DBS in a rat model of learned helplessness (LH) and analyzed mammalian target of rapamycin (mTOR) phosphorylation...
August 24, 2017: Neuroscience
https://www.readbyqxmd.com/read/28843434/when-patients-and-their-families-feel-like-hostages-to-health-care
#18
REVIEW
Leonard L Berry, Tracey S Danaher, Dan Beckham, Rana L A Awdish, Kedar S Mate
Patients are often reluctant to assert their interests in the presence of clinicians, whom they see as experts. The higher the stakes of a health decision, the more entrenched the socially sanctioned roles of patient and clinician can become. As a result, many patients are susceptible to "hostage bargaining syndrome" (HBS), whereby they behave as if negotiating for their health from a position of fear and confusion. It may manifest as understating a concern, asking for less than what is desired or needed, or even remaining silent against one's better judgment...
September 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28798343/isoflurane-produces-antidepressant-effects-and-induces-trkb-signaling-in-rodents
#19
Hanna Antila, Maria Ryazantseva, Dina Popova, Pia Sipilä, Ramon Guirado, Samuel Kohtala, Ipek Yalcin, Jesse Lindholm, Liisa Vesa, Vinicius Sato, Joshua Cordeira, Henri Autio, Mikhail Kislin, Maribel Rios, Sâmia Joca, Plinio Casarotto, Leonard Khiroug, Sari Lauri, Tomi Taira, Eero Castrén, Tomi Rantamäki
A brief burst-suppressing isoflurane anesthesia has been shown to rapidly alleviate symptoms of depression in a subset of patients, but the neurobiological basis of these observations remains obscure. We show that a single isoflurane anesthesia produces antidepressant-like behavioural effects in the learned helplessness paradigm and regulates molecular events implicated in the mechanism of action of rapid-acting antidepressant ketamine: activation of brain-derived neurotrophic factor (BDNF) receptor TrkB, facilitation of mammalian target of rapamycin (mTOR) signaling pathway and inhibition of glycogen synthase kinase 3β (GSK3β)...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28782590/may-the-use-of-different-background-strains-strain-the-stress-related-phenotype-of-gr-mice
#20
Miriam A Vogt, Natascha Pfeiffer, Anne Marie Le Guisquet, Christiane Brandwein, Bruno Brizard, Peter Gass, Catherine Belzung, Sabine Chourbaji
Genetically altered mice are available on different background strains. While respective backcrosses are often performed for pragmatic reasons, e.g. references, comparability, or existing protocols, the interaction between the mutations per se and the background strain often remains a neglected factor. The heterozygous mutation of the glucocorticoid receptor gene (GR) represents a well-examined model for depressive-like behavior in mice. To address the question in how far a robust depressive-like phenotype on a distinct background strain may allow a generalized conclusion, we analyzed respective phenotypes in two commonly used inbred strains: i...
August 3, 2017: Behavioural Brain Research
keyword
keyword
88251
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"