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learned helplessness

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https://www.readbyqxmd.com/read/28062258/mice-subjected-to-uncontrollable-electric-shocks-show-depression-like-behaviors-irrespective-of-their-state-of-helplessness
#1
Jin Yong Kim, Soo Hyun Yang, Jihyun Kwon, Hyun Woo Lee, Hyun Kim
The unpredictable and inescapable electric shock-induced "learned helplessness" paradigm has long been used to produce an animal model of depression to identify the molecules associated with depressive symptoms or to assess the efficacy of pharmacological treatments for depression. After exposure to unpredictable and inescapable shocks (uncontrollable stress), most of mice showed defect in escape behavior in active avoidance test (learned helplessness, LH), while others did not (non-learned helplessness, NLH)...
January 3, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28025131/glutamatergic-stimulation-of-the-left-dentate-gyrus-abolishes-depressive-like-behaviors-in-a-rat-learned-helplessness-paradigm
#2
Jeho Seo, Hojin Cho, Gun Tae Kim, Chul Hoon Kim, Dong Goo Kim
BACKGROUND: Episodic experiences of stress have been identified as the leading cause of major depressive disorder (MDD). The occurrence of MDD is profoundly influenced by the individual's coping strategy, rather than the severity of the stress itself. Resting brain activity has been shown to alter in several mental disorders. However, the functional relationship between resting brain activity and coping strategies has not yet been studied. In the present study, we observed different patterns of resting brain activity in rats that had determined either positive (resilient to stress) or negative (vulnerable to stress) coping strategies, and examined whether modulation of the preset resting brain activity could influence the behavioral phenotype associated with negative coping strategy (i...
December 23, 2016: NeuroImage
https://www.readbyqxmd.com/read/27994405/learned-helplessness
#3
EDITORIAL
Sivakumar Nuvvula
No abstract text is available yet for this article.
October 2016: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/27919695/metabolomics-identifies-perturbations-in-amino-acid-metabolism-in-the-prefrontal-cortex-of-the-learned-helplessness-rat-model-of-depression
#4
Xinyu Zhou, Lanxiang Liu, Yuqing Zhang, Juncai Pu, Lining Yang, Chanjuan Zhou, Shuai Yuan, Hanping Zhang, Peng Xie
Major depressive disorder is a serious psychiatric condition associated with high rates of suicide and is a leading cause of health burden worldwide. However, the underlying molecular mechanisms of major depression are still essentially unclear. In our study, a non-targeted gas chromatography-mass spectrometry-based metabolomics approach was used to investigate metabolic changes in the prefrontal cortex of the learned helplessness (LH) rat model of depression. Body-weight measurements and behavioral tests including the active escape test, sucrose preference test, forced swimming test, elevated plus-maze and open field test were used to assess changes in the behavioral spectrum after inescapable footshock stress...
December 3, 2016: Neuroscience
https://www.readbyqxmd.com/read/27914356/can-podcasts-for-assessment-guidance-and-feedback-promote-self-efficacy-among-undergraduate-nursing-students-a-qualitative-study
#5
Linda C McSwiggan, Maureen Campbell
BACKGROUND: Improving assessment guidance and feedback for students has become an international priority within higher education. Podcasts have been proposed as a tool for enhancing teaching, learning and assessment. However, a stronger theory-based rationale for using podcasts, particularly as a means of facilitating assessment guidance and feedback, is required. OBJECTIVE: To explore students' experiences of using podcasts for assessment guidance and feedback...
February 2017: Nurse Education Today
https://www.readbyqxmd.com/read/27895566/allostatic-self-efficacy-a-metacognitive-theory-of-dyshomeostasis-induced-fatigue-and-depression
#6
Klaas E Stephan, Zina M Manjaly, Christoph D Mathys, Lilian A E Weber, Saee Paliwal, Tim Gard, Marc Tittgemeyer, Stephen M Fleming, Helene Haker, Anil K Seth, Frederike H Petzschner
This paper outlines a hierarchical Bayesian framework for interoception, homeostatic/allostatic control, and meta-cognition that connects fatigue and depression to the experience of chronic dyshomeostasis. Specifically, viewing interoception as the inversion of a generative model of viscerosensory inputs allows for a formal definition of dyshomeostasis (as chronically enhanced surprise about bodily signals, or, equivalently, low evidence for the brain's model of bodily states) and allostasis (as a change in prior beliefs or predictions which define setpoints for homeostatic reflex arcs)...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27882537/neurochemical-and-behavioral-effects-of-hypidone-hydrochloride-yl-0919-a-novel-combined-selective-serotonin-reuptake-inhibitor-and-partial-5-ht1a-agonist
#7
Li-Ming Zhang, Xiao-Yun Wang, Nan Zhao, Yu-Lu Wang, Xiao-Xu Hu, Yu-Hua Ran, Yan-Qin Liu, You-Zhi Zhang, Ri-Fang Yang, Yun-Feng Li
The purpose of the present study was to investigate the pharmacology of hypidone hydrochloride (YL-0919), a novel selective serotonin reuptake inhibitor (SSRI) and 5-hydroxytryptamine (5-HT)1A receptor agonist with high affinity for serotonin transporter (SERT) and 5-HT1A receptors. YL-0919 promoted [(35) S]GTPγ S binding at 85% of the magnitude of the full 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), suggesting that YL-0919 is a high-efficacy partial agonist of 5-HT1A receptors...
November 24, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27875580/inescapable-stress-changes-walking-behavior-in-flies-learned-helplessness-revisited
#8
Sophie Batsching, Reinhard Wolf, Martin Heisenberg
Like other animals flies develop a state of learned helplessness in response to unescapable aversive events. To show this, two flies, one 'master', one 'yoked', are each confined to a dark, small chamber and exposed to the same sequence of mild electric shocks. Both receive these shocks when the master fly stops walking for more than a second. Behavior in the two animals is differently affected by the shocks. Yoked flies are transiently impaired in place learning and take longer than master flies to exit from the chamber towards light...
2016: PloS One
https://www.readbyqxmd.com/read/27857171/strong-interactions-between-learned-helplessness-and-risky-decision-making-in-a-rat-gambling-model
#9
José N Nobrega, Parisa S Hedayatmofidi, Daniela S Lobo
Risky decision-making is characteristic of depression and of addictive disorders, including pathological gambling. However it is not clear whether a propensity to risky choices predisposes to depressive symptoms or whether the converse is the case. Here we tested the hypothesis that rats showing risky decision-making in a rat gambling task (rGT) would be more prone to depressive-like behaviour in the learned helplessness (LH) model. Results showed that baseline rGT choice behaviour did not predict escape deficits in the LH protocol...
November 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27837523/linguistic-evidence-for-the-failure-mindset-as-a-predictor-of-life-span-longevity
#10
Ian B Penzel, Michelle R Persich, Ryan L Boyd, Michael D Robinson
BACKGROUND: When people think that their efforts will fail to achieve positive outcomes, they sometimes give up their efforts after control, which can have negative health consequences. PURPOSE: Problematic orientations of this type, such as pessimism, helplessness, or fatalism, seem likely to be associated with a cognitive mindset marked by higher levels of accessibility for failure words or concepts. Thus, the purpose of the present research was to determine whether there are individual differences in the frequency with which people think about failure, which in turn are likely to impact health across large spans of time...
November 11, 2016: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/27793217/exercise-and-prebiotics-produce-stress-resistance-converging-impacts-on-stress-protective-and-butyrate-producing-gut-bacteria
#11
A Mika, N Rumian, A B Loughridge, M Fleshner
The gut microbial ecosystem can mediate the negative health impacts of stress on the host. Stressor-induced disruptions in microbial ecology (dysbiosis) can lead to maladaptive health effects, while certain probiotic organisms and their metabolites can protect against these negative impacts. Prebiotic diets and exercise are feasible and cost-effective strategies that can increase stress-protective bacteria and produce resistance against the detrimental behavioral and neurobiological impacts of stress. The goal of this review is to describe research demonstrating that both prebiotic diets and exercise produce adaptations in gut ecology and the brain that arm the organism against inescapable stress-induced learned helplessness...
2016: International Review of Neurobiology
https://www.readbyqxmd.com/read/27769904/learned-helplessness-activates-hippocampal-microglia-in-rats-a-potential-target-for-the-antidepressant-imipramine
#12
Masaaki Iwata, Hisahito Ishida, Koichi Kaneko, Yukihiko Shirayama
An accumulating body of evidence has demonstrated that inflammation is associated with the pathology of depression. We recently found that psychological stress induces inflammation in the hippocampus of the rat brain through the inflammasome, a component of the innate immune system. Microglia, the resident macrophages in the brain, play a central role in the innate immune system and express inflammasomes; thus, we hypothesized that hippocampal microglia would be key mediators in the development of depression via stress-induced inflammation...
November 2016: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/27763700/early-life-diets-with-prebiotics-and-bioactive-milk-fractions-attenuate-the-impact-of-stress-on-learned-helplessness-behaviours-and-alter-gene-expression-within-neural-circuits-important-for-stress-resistance
#13
Agnieszka Mika, Heidi E W Day, Alexander Martinez, Nicole L Rumian, Benjamin N Greenwood, Maciej Chichlowski, Brian M Berg, Monika Fleshner
Manipulating gut microbes may improve mental health. Prebiotics are indigestible compounds that increase the growth and activity of health-promoting microorganisms, yet few studies have examined how prebiotics affect CNS function. Using an acute inescapable stressor known to produce learned helplessness behaviours such as failure to escape and exaggerated fear, we tested whether early life supplementation of a blend of two prebiotics, galactooligosaccharide (GOS) and polydextrose (PDX), and the glycoprotein lactoferrin (LAC) would attenuate behavioural and biological responses to stress later in life...
October 20, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27723376/ketamine-up-regulates-a-cluster-of-intronic-mirnas-within-the-serotonin-receptor-2c-gene-by-inhibiting-glycogen-synthase-kinase-3
#14
Steven F Grieco, Dmitry Velmeshev, Marco Magistri, Hagit Eldar-Finkelman, Mohammad A Faghihi, Richard S Jope, Eleonore Beurel
OBJECTIVES: We examined mechanisms that contribute to the rapid antidepressant effect of ketamine in mice that is dependent on glycogen synthase kinase-3 (GSK3) inhibition. METHODS: We measured serotonergic (5HT)-2C-receptor (5HTR2C) cluster microRNA (miRNA) levels in mouse hippocampus after administering an antidepressant dose of ketamine (10 mg/kg) in wild-type and GSK3 knockin mice, after GSK3 inhibition with L803-mts, and in learned helpless mice. RESULTS: Ketamine up-regulated cluster miRNAs 448-3p, 764-5p, 1264-3p, 1298-5p and 1912-3p (2- to 11-fold)...
October 10, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27721543/anxiolytic-antidepressant-and-antistress-activities-of-the-aqueous-extract-of-cinnamomum-tamala-nees-and-eberm-in-rats
#15
Gayaprasad Upadhyay, Sarvesh Khoshla, Ramoji Kosuru, Sanjay Singh
OBJECTIVE: The current study was designed to explore anxiolytic, antidepressant, and antistress actions of Cinnamomum tamala (CT) leaves (aqueous extract) in rats. MATERIALS AND METHODS: Behavioral procedures of anxiety, depression, and stress were assessed in rats. CT (100, 200, and 400 mg/kg) was given once a daily for 7 days via oral route and the efficacy was matched by those elicited by lorazepam (1 mg/kg, p.o.), imipramine (10 mg/kg, p.o.), and Withania somnifera (100 mg/kg, p...
September 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/27710008/anticipatory-fear-and-helplessness-predict-ptsd-and-depression-in-domestic-violence-survivors
#16
Ebru Salcioglu, Sevim Urhan, Tugba Pirinccioglu, Sule Aydin
OBJECTIVE: Embracing the conceptual framework of contemporary learning theory, this study tested the hypothesis that anticipatory fear due to a sense of ongoing threat to safety and sense of helplessness in life would be the strongest determinants of PTSD and depression in domestic violence survivors. METHOD: Participants were 220 domestic violence survivors recruited consecutively from 12 shelters for women in Turkey (response rate 70%). They were assessed with the Semi-Structured Interview for Survivors of Domestic Violence, Traumatic Stress Symptom Checklist, Depression Rating Scale, and Fear and Sense of Control Scale...
January 2017: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/27663969/stress-based-animal-models-of-depression-do-we-actually-know-what-we-are-doing
#17
Xin Yin, Nuri Guven, Nikolas Dietis
Depression is one of the leading causes of disability and a significant health-concern worldwide. Much of our current understanding on the pathogenesis of depression and the pharmacology of antidepressant drugs is based on pre-clinical models. Three of the most popular stress-based rodent models are the forced swimming test, the chronic mild stress paradigm and the learned helplessness model. Despite their recognizable advantages and limitations, they are associated with an immense variability due to the high number of design parameters that define them...
September 20, 2016: Brain Research
https://www.readbyqxmd.com/read/27623118/-autism-spectrum-disorder-and-evaluation-of-perceived-stress-parents-and-professionals-study-of-the-psychometric-properties-of-a-french-adaptation-of-the-appraisal-of-life-event-scale-ales-vf
#18
É Cappe, N Poirier, É Boujut, N Nader-Grosbois, C Dionne, A Boulard
INTRODUCTION: Autism and related disorders are grouped into the category of « Autism Spectrum Disorder » (ASD) in the DSM-5. This appellation reflects the idea of a dimensional representation of autism that combines symptoms and characteristics that vary in severity and intensity. Despite common characteristics, there are varying degrees in intensity and in the onset of symptoms, ranging from a disability that can be very heavy with a total lack of communication and major disorders associated with the existence of a relative autonomy associated, sometimes, with extraordinary intellectual abilities...
September 9, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27569602/rapid-and-sustained-antidepressant-properties-of-an-nmda-antagonist-monoamine-reuptake-inhibitor-identified-via-transporter-based-virtual-screening
#19
Jeffery N Talbot, Laura M Geffert, Jessica E Jorvig, Ruben I Goldstein, Cienna L Nielsen, Nicholas E Wolters, Mary Ellen Amos, Caitlin A Munro, Elizabeth Dallman, Maddalena Mereu, Gianluigi Tanda, Jonathan L Katz, Martín Indarte, Jeffry D Madura, Hailey Choi, Rehana K Leak, Christopher K Surratt
Rational design of lead compounds targeting monoamine transporters (MATs) is critical to developing novel therapeutics to treat psychiatric disorders including depression and substance abuse. A 3-D dopamine transporter (DAT) computer model was used to virtually screen a commercially available small molecule library for high DAT affinity drug-like compounds. One hit, coded "MI-4", inhibited human dopamine, norepinephrine, and serotonin transporters in vitro. In vivo administration in mice induced robust, dose-dependent antidepressant-like behaviors in learned helplessness models (tail suspension and forced swim tests)...
November 2016: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/27543827/changes-of-tspo-mediated-mitophagy-signaling-pathway-in-learned-helplessness-mice
#20
Dongmei Li, Ji Zheng, Mingyang Wang, Lu Feng, Zhili Ren, Yanyong Liu, Nan Yang, Pingping Zuo
Low response rate was witnessed with the present monoaminergic based antidepressants, urging a need for new therapeutic target identification. Accumulated evidences strongly suggest that mitochondrial deficit is implicated in major depression and 18kDa translocator protein (TSPO) plays an important role in regulating mitochondrial function. However the changes of TSPO and TSPO mediated mitophagy pathway in the depressive brain is unclear. In present study, a well validated animal model of depression, learned helplessness (LH), was employed to investigate the relevant changes...
November 30, 2016: Psychiatry Research
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