Read by QxMD icon Read

Mystical experience

Noah W Sweat, Larry W Bates, Peter S Hendricks
Developing methods for improving creativity is of broad interest. Classic psychedelics may enhance creativity; however, the underlying mechanisms of action are unknown. This study was designed to assess whether a relationship exists between naturalistic classic psychedelic use and heightened creative problem-solving ability and if so, whether this is mediated by lifetime mystical experience. Participants (N = 68) completed a survey battery assessing lifetime mystical experience and circumstances surrounding the most memorable experience...
October 8, 2016: Journal of Psychoactive Drugs
Matthias E Liechti, Patrick C Dolder, Yasmin Schmid
RATIONALE: Lysergic acid diethylamide (LSD) is used recreationally and in clinical research. Acute mystical-type experiences that are acutely induced by hallucinogens are thought to contribute to their potential therapeutic effects. However, no data have been reported on LSD-induced mystical experiences and their relationship to alterations of consciousness. Additionally, LSD dose- and concentration-response functions with regard to alterations of consciousness are lacking. METHODS: We conducted two placebo-controlled, double-blind, cross-over studies using oral administration of 100 and 200 μg LSD in 24 and 16 subjects, respectively...
October 7, 2016: Psychopharmacology
José Carlos Bouso, Eduardo José Pedrero-Pérez, Sam Gandy, Miguel Ángel Alcázar-Córcoles
OBJECTIVE: In the present study we explored the psychometric properties of three widely used questionnaires to assess the subjective effects of hallucinogens: the Hallucinogen Rating Scale (HRS), the Mystical Experience Questionnaire (MEQ), and the Addiction Research Center Inventory (ARCI). METHODS: These three questionnaires were administered to a sample of 158 subjects (100 men) after taking ayahuasca, a hallucinogen whose main active component is N,N-dimethyltryptamine (DMT)...
September 2016: Human Psychopharmacology
Matthew M Nour, Lisa Evans, David Nutt, Robin L Carhart-Harris
AIMS: The experience of a compromised sense of "self", termed ego-dissolution, is a key feature of the psychedelic experience. This study aimed to validate the Ego-Dissolution Inventory (EDI), a new 8-item self-report scale designed to measure ego-dissolution. Additionally, we aimed to investigate the specificity of the relationship between psychedelics and ego-dissolution. METHOD: Sixteen items relating to altered ego-consciousness were included in an internet questionnaire; eight relating to the experience of ego-dissolution (comprising the EDI), and eight relating to the antithetical experience of increased self-assuredness, termed ego-inflation...
2016: Frontiers in Human Neuroscience
M Arias
All human experiences, including mystical and religious ones, are the result of brain functional activity. Thanks to the study of cases of ecstatic epilepsy with structural (MRI) and functional neuroimaging (fMRI, PET, SPECT) and neurophysiological technologies (recording and stimulation with intracranial electrodes), we now have a better knowledge of certain mental states which involve pleasant and affective symptoms and clarity of mind. These ecstatic experiences are thought to be caused by the activation of the anterior insular cortex and some neuronal networks (basically related to mirror neurons and salience) participating in introspection, social cognition, memory, and emotional processes...
June 20, 2016: Neurología: Publicación Oficial de la Sociedad Española de Neurología
Josef Parnas, Mads Gram Henriksen
Mysticism and schizophrenia are different categories of human existence and experience. Nonetheless, they exhibit important phenomenological affinities, which, however, remain largely unaddressed. In this study, we explore structural analogies between key features of mysticism and major clinical-phenomenological aspects of the schizophrenia spectrum disorders-i.e. attitudes, the nature of experience, and the 'other', mystical or psychotic reality. Not only do these features gravitate around the issue of the basic dimensions of consciousness, they crucially seem to implicate and presuppose a specific alteration of the very structure of consciousness...
July 2016: Consciousness and Cognition
Eelke M Bos, Jochem K H Spoor, Marion Smits, Joost W Schouten, Arnaud J P E Vincent
BACKGROUND: The out-of-body experience (OBE), during which a person feels as if he or she is spatially removed from the physical body, is a mystical phenomenon because of its association with near-death experiences. Literature implicates the cortex at the temporoparietal junction (TPJ) as the possible anatomic substrate for OBE. CASE DESCRIPTION: We present a patient who had an out-of-body experience during an awake craniotomy for resection of low-grade glioma. During surgery, stimulation of subcortical white matter in the left TPJ repetitively induced OBEs, in which the patient felt as if she was floating above the operating table looking down on herself...
August 2016: World Neurosurgery
Markus Gschwind, Fabienne Picard
Ecstatic epileptic seizures are a rare but compelling epileptic entity. During the first seconds of these seizures, ecstatic auras provoke feelings of well-being, intense serenity, bliss, and "enhanced self-awareness." They are associated with the impression of time dilation, and can be described as a mystic experience by some patients. The functional neuroanatomy of ecstatic seizures is still debated. During recent years several patients presenting with ecstatic auras have been reported by others and us (in total n = 52); a few of them in the setting of presurgical evaluation including electrical brain stimulation...
2016: Frontiers in Behavioral Neuroscience
Irene Cristofori, Joseph Bulbulia, John H Shaver, Marc Wilson, Frank Krueger, Jordan Grafman
Mystical experiences, or subjectively believed encounters with a supernatural world, are widely reported across cultures and throughout human history. Previous theories speculate that executive brain functions underpin mystical experiences. To evaluate causal hypotheses, structural studies of brain lesion are required. Previous studies suffer from small samples or do not have valid measures of cognitive functioning prior to injury. We investigated mystical experience among participants from the Vietnam Head Injury Study and compared those who suffered penetrating traumatic brain injury (pTBI; n=116) with matched healthy controls (HC; n=32)...
January 8, 2016: Neuropsychologia
Frederick S Barrett, Matthew W Johnson, Roland R Griffiths
The 30-item revised Mystical Experience Questionnaire (MEQ30) was previously developed within an online survey of mystical-type experiences occasioned by psilocybin-containing mushrooms. The rated experiences occurred on average eight years before completion of the questionnaire. The current paper validates the MEQ30 using data from experimental studies with controlled doses of psilocybin. Data were pooled and analyzed from five laboratory experiments in which participants (n=184) received a moderate to high oral dose of psilocybin (at least 20 mg/70 kg)...
November 2015: Journal of Psychopharmacology
Paulo H C Dias, Gilberto Safra
This study presents a clinical conception of the human being as the paradox between immanence and transcendence. Through an exposition of the clinical conceptions of Brazilian author Gilberto Safra, we search for an integral manner in which to understand mystical experience as a way to rethink the ontological conceptions inherent to clinical practice. In such perspective, we elaborate a critique of both the psychological-only approach to mystical experience as well as the spiritual-only approach. We present it through the life of Indian mystic Ramakrishna, by comparing the interpretation different authors make of his experiences and placing our own perspective...
December 2016: Journal of Religion and Health
Bruno Marchal
I will explain how the mathematicians have discovered the universal numbers, or abstract computer, and I will explain some abstract biology, mainly self-reproduction and embryogenesis. Then I will explain how and why, and in which sense, some of those numbers can dream and why their dreams can glue together and must, when we assume computationalism in cognitive science, generate a phenomenological physics, as part of a larger phenomenological theology (in the sense of the greek theologians). The title should have been "From Biology to Physics, through the Phenomenological Theology of the Universal Numbers", if that was not too long for a title...
December 2015: Progress in Biophysics and Molecular Biology
Lucia Fattori, Cesare Secchi
The authors present two clinical cases involving an existential crisis which led the patients to lose what had been the foundation in their lives, their faith. Although the therapeutic settings differ--the first patient had a few psychotherapy sessions following a psychotic episode with a mystical background, while the second was in the final stage of analytic treatment - the authors highlight how in both clinical cases a loss of faith becomes a total and urgent crisis of the Self. The fracture which ensues seems to generate an intense engagement of the body which, paradoxically during a loss of faith, induces an experience of ecstasy of the kind that has traditionally been reported...
August 2015: International Journal of Psycho-analysis
John M de Castro
Contemplative practices can have profound effects on mindfulness and on physical and sensory and mystical experiences. Individuals who self-reported meditation, yoga, contemplative prayer, or a combination of practices and their patterns of practice were compared for mindfulness, kundalini effects, and mystical experiences. The results suggest that the amount of practice but not the pattern and social conditions of practice influences mindfulness and possibly mystical experiences. Meditation, yoga, contemplative prayer, or a combination of practices all were found to be associated with enhancements of mindfulness, kundalini effects, and mystical experiences, but meditation had particularly strong associations and may be the basis of the associations of yoga and prayer with these outcomes...
September 2015: Consciousness and Cognition
Francisco De Assis Aquino Gondim, Sarah H Griesbach, Florian P Thomas
OBJECTIVE: To discuss the neuropsychiatric phenomena described in Cantigas de Santa Maria (Canticles of St. Mary [CSM]). BACKGROUND: CSM is a collection of 427 canticles composed in Galician-Portuguese between 1252 and 1284 at the Court of King Alfonso X the Wise of Spain (1221-1284). The canticles (of which 9 are repeated) include devotional and liturgical poems and 353 narrative stories consisting mainly of depictions of Marian miracles. Most are set to music and many are illustrated...
May 12, 2015: Neurology
Kevin Nelson
No abstract text is available yet for this article.
March 2015: Missouri Medicine
Eylert Brodtkorb, Karl Otto Nakken
The story of Wise-Knut is remarkable. He was born in a poor mountain district in Norway in 1792 and lived for 84years. He had severe and untreated epilepsy with apparent ictal, postictal, and interictal religious symptoms. He heard voices and had religious delusions; a spiritual awakening after a seizure cluster was a turning point in his life. Contemporary biographers have narrated his major life events in detail, but without a precise separation between ictal and postictal spiritual symptoms. Religious and supernatural significance was attributed to his experiences; he himself believed that his extraordinary abilities were a gift from God: "The prophets have had it like myself...
May 2015: Epilepsy & Behavior: E&B
Michael P Bogenschutz, Matthew W Johnson
Addictive disorders are very common and have devastating individual and social consequences. Currently available treatment is moderately effective at best. After many years of neglect, there is renewed interest in potential clinical uses for classic hallucinogens in the treatment of addictions and other behavioral health conditions. In this paper we provide a comprehensive review of both historical and recent clinical research on the use of classic hallucinogens in the treatment of addiction, selectively review other relevant research concerning hallucinogens, and suggest directions for future research...
January 4, 2016: Progress in Neuro-psychopharmacology & Biological Psychiatry
Vernon M Neppe, Edward R Close
THREE CORE CONCEPTS: We argue that "non-local" events require further descriptors for us to understand the degree of non-locality, what the framework of the observer describing it is, and where we humans are located relative to the ostensible non-locality. This suggests three critical factors: Relative to, from the framework of, and a hierarchy of "to what degree?" "Non-locality" without the prefix "relative" compromises its description by making it an absolute: We must scientifically ensure that, qualitatively, we can describe events that correspond with each other-like with like-and differentiate these events from those that are hierarchically dissimilar...
March 2015: Explore: the Journal of Science and Healing
S Turton, D J Nutt, R L Carhart-Harris
BACKGROUND: This report documents the phenomenology of the subjective experiences of 15 healthy psychedelic experienced volunteers who were involved in a functional magnetic resonance imaging (fMRI) study that was designed to image the brain effects of intravenous psilocybin. METHODS: The participants underwent a semi-structured interview exploring the effects of psilocybin in the MRI scanner. These interviews were analysed by Interpretative Phenomenological Analysis...
2014: Current Drug Abuse Reviews
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"