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Weihua Mai, Dongqing Lu, Xingwei Liu, Ling Chen
To investigate the expression profile of monocyte chemoattractant peptide-1 (MCP-1) by keratinocytes after nickel exposure and to identify its role for leucocyte migration during nickel-induced occupational allergic contact dermatitis (OACD), 26 workers diagnosed with nickel-induced OACD were enrolled. Skin biopsies from the positive nickel-challenged sites at different time points were assessed by immunohistochemistry (IHC) for MCP-1, CD68, CD45RO, and in situ hybridization (ISH) for MCP-1, using chronic periumbilical dermititis as controls...
January 2018: Toxicology and Industrial Health
Maria Dermit, Martin Dodel, Faraz K Mardakheh
Regulation of protein translation constitutes a crucial step in control of gene expression. In comparison to transcriptional regulation, however, translational control has remained a significantly under-studied layer of gene expression. This trend is now beginning to shift thanks to recent advances in next-generation sequencing, proteomics, and microscopy based methodologies which allow accurate monitoring of protein translation rates, from single target messenger RNA molecules to genome-wide scale studies...
November 21, 2017: Molecular BioSystems
Maria Dermit, Arran Dokal, Pedro R Cutillas
Cells integrate extracellular signals into appropriate responses through a complex network of biochemical reactions driven by the activity of protein and lipid kinases, among other proteins. In order to understand this complexity, new approaches, both experimental and computational, have recently been developed with the aim to identify regulatory kinases and infer their activation status in the context of their signalling network. Here, we review such approaches with particular focus on those based on phosphoproteomics...
September 2017: FEBS Letters
M Dermit, P Casado, V Rajeeve, E H Wilkes, D E Foxler, H Campbell, S Critchlow, T V Sharp, J G Gribben, R Unwin, P R Cutillas
Compounds targeting phosphatidylinositol-3-kinase/mammalian target of rapamycin (PI3K/mTOR) signaling are being investigated in multiple clinical settings, but drug resistance may reduce their benefit. Compound rechallenge after drug holidays can overcome such resistance, yet little is known about the impact of drug holidays on cell biochemistry. We found that PI3K inhibitor (PI3Ki)-resistant cells cultured in the absence of PI3Ki developed a proliferative defect, increased oxygen consumption and accumulated reactive oxygen species (ROS), leading to lactate production through hypoxia-inducible factor-1α...
May 11, 2017: Oncogene
Javier Arnaiz, Tatiana Piedra, Enrique Marco de Lucas, Ana Maria Arnaiz, Marta Pelaz, Vanessa Gomez-Dermit, Ana Canga
OBJECTIVE: The objective of this article is to present a comprehensive review of apophysitis of the lower limb regarding anatomy, physiopathology, clinical findings, differential diagnosis, and imaging features with special emphasis on MRI. CONCLUSION: Apophysitis, which is inflammation of the traction epiphysis resulting from chronic trauma, is a common abnormality that affects the growing child. Understanding the physiopathology of apophysitis is essential for a precise diagnosis on MRI...
March 2011: AJR. American Journal of Roentgenology
M Bustamante, V Gomez-Dermit, I García, A Pontón, J M Revuelta, A Gonzalez-Tutor
Prosthetic infection is one of the most serious complications of vascular surgery, and its treatment remains a surgical challenge. Good results have been reported using in situ replacement with arterial allografts, but late degeneration of the graft itself may necessitate further repair. We report a case of rupture and pseudoaneurysm formation of an iliac artery homograft urgently treated by endoluminal grafting with complete and immediate exclusion of the sac without complications. At 6-month follow-up angio-computed tomography showed patency of the vascular stent graft without leak evidence...
May 2009: Annals of Vascular Surgery
Vanesa Gomez-Dermit, E Gallardo, R Landeras, Fernández Echevarría, R García Barredo
PURPOSE: To describe the gray-scale Doppler and sonographic features of a series of subcutaneous angioleiomyomas. METHODS: The sonographic appearances of 10 pathologically proven angioleiomyomas were retrospectively reviewed; 4 in women and 6 in men, with an age range from 33 to 77 years. We evaluated size, shape, echo pattern, margins, location, relationships with adjacent structures, and vascularity. Examinations were performed using a multifrequency linear array transducer (9-11 MHz) connected to a Logiq 500 scanner (GE, Milwaukee, Wl)...
February 2006: Journal of Clinical Ultrasound: JCU
No abstract text is available yet for this article.
September 1951: Atti Della Società Italiana di Dermatologia e Sifilografia e Delle Sezioni Interprovinciali
David Cohen et al.
No abstract text is available yet for this article.
June 2003: American Journal of Contact Dermatitis: Official Journal of the American Contact Dermatitis Society
A Taïeb, N Diris, F Boralevi, C Labrèze
Herpetic gingivostomatitis (HGS) is the predominant manifestation of cutaneomucosal herpes in children with HSV1 primary infection before the age of 3 years. The infection is self limiting and lasts 10 to 14 days. Pain and dysphagia are particularly important during the first week of infection and may necessitate parenteral rehydratation and administration of antalgesics. HGS in the young child causes substantial morbidity leading to hospital and social costs (work stoppage for parents). The clinical course is generally benign with the exception of forms with important extension, eczema, herpeticum Kaposi-Juliusberg pustulosis observed at this age only in children with atopic dermititis...
April 2002: Annales de Dermatologie et de Vénéréologie
P Vereecken, S Tas, S Verraes, G De Dobbeleer
We report the case of a 39-year-old patient, gardener, who develops, during a beautiful sunny summerday, an erythemato-bullous eruption of the forearms. The diagnosis is a Contact Phototoxic Phytodermatitis (dermite des prés, dermatitis bullosa striata) with a classical presentation. This clinical observation gives us the opportunity to remind of the clinical and biological aspects of this dermatosis, whose frequency is probably underestimated, related to an often rapidly favourable evolution.
June 1998: Revue Médicale de Bruxelles
E Bourrat, M Rybojad, S Deplus, P Morel
INTRODUCTION: Rosacea ia an uncommon facial eruption in children. We report a case of rosacea associated with a specific episcleritis. CASE REPORT: A 10-year-old girl consulted for an erythematous papular and pustular eruption of the mid face of 1 month duration. The child complained that she had had a red painful right eye for 6 months. There was no argument for acne, periorificial granulomatous dermititis or for sarcoidosis. The ophthalmological examination gave the diagnosis of ocular and cutaneous rosacea...
1996: Annales de Dermatologie et de Vénéréologie
O A al-Sheikh, M O Gad el-Rab
BACKGROUND: No reports are available on allergic contact dermatitis in Saudi Arabia, although it seems to be a common skin problem. We attempted to explore certain clinical aspects in addition to the profile of sensitizing allergens in our area. As no standard panel for patch testing is available in our geographic region, we examined the suitability of the European Standard Series. METHODS: Patch testing was performed on 271 consecutive patients with various forms of dermititis, referred for evaluation of possible allergic contact dermatitis...
July 1996: International Journal of Dermatology
F Sáez Garmendia, J A Lopez Ruiz, A Martinez Alvarez, J M Pena Sarnago, J A Calonge Ratia, F Munoz Dermit
A case of Bouveret's syndrome which later presented as a jejunal obstruction is reported. Special reference is made to the echographic findings. Bouveret's syndrome has a double-arch-shadow image in the zone of the gallbladder bed on ultrasound examination. So far, this sign has been considered specific for gallstones inside the gallbladder.
August 1984: European Journal of Radiology
T F Downham, D J Birmingham
A case of allergic contact dermititis secondary to photographic print coating liquid is described herein. Patch test reactions to the mixture were positive, but negative to the individual components which included dimethylhydantoin formaldehyde resin, the logical allergen. Formaldehyde resin allergic dermatitis, in some instances, may not be reproduced by patch testing because of various contributing factors. In this patient, the combination of components was necessary to yield a sensitivity reaction. To the best of our knowledge contact dermatitis secondary to this product has not been previously reported...
April 1980: Cutis; Cutaneous Medicine for the Practitioner
M Goos, F Odeh
No abstract text is available yet for this article.
1972: VASA. Zeitschrift Für Gefässkrankheiten
M B Poh-Fitzpatrick
Many complications beset the skin formed over burn wounds, whether by primary re-epithelialization or grafting techniques, and these can evolve over days to decades. Mechanisms by which re-epithelializations, reattachment, and remodeling may result in skin prone to blistering, dryness, itching, contact dermititis, photosensitivity, and hypertrophic changes relatively early in the course of healing are considered, and therapeutic approaches are discussed. Late development of benign and malignant lesions calls for long-term surveillance of the healed skin of burned patients...
July 1992: Clinics in Plastic Surgery
E J Feuerman
No abstract text is available yet for this article.
May 15, 1975: Harefuah
M I White
This study of seven patients with an allergic contact dermititis from ethylenediamine has shown that sensitisation to topical antihistamines and disodium ethylenediamine tetra-acetate is not inevitable in a allergic contact dermatitis from ethylenediamine.
October 1978: Contact Dermatitis
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