keyword
https://read.qxmd.com/read/38536505/metabolic-changes-contribute-to-maladaptive-right-ventricular-hypertrophy-in-pulmonary-hypertension-beyond-pressure-overload-an-integrative-imaging-and-omics-investigation
#1
JOURNAL ARTICLE
Inés García-Lunar, Inmaculada Jorge, Jorge Sáiz, Núria Solanes, Ana Paula Dantas, Juan José Rodríguez-Arias, María Ascaso, Carlos Galán-Arriola, Francisco Rafael Jiménez, Elena Sandoval, Jorge Nuche, Maria Moran-Garrido, Emilio Camafeita, Montserrat Rigol, Javier Sánchez-Gonzalez, Valentín Fuster, Jesús Vázquez, Coral Barbas, Borja Ibáñez, Daniel Pereda, Ana García-Álvarez
Right ventricular (RV) failure remains the strongest determinant of survival in pulmonary hypertension (PH). We aimed to identify relevant mechanisms, beyond pressure overload, associated with maladaptive RV hypertrophy in PH. To separate the effect of pressure overload from other potential mechanisms, we developed in pigs two experimental models of PH (M1, by pulmonary vein banding and M2, by aorto-pulmonary shunting) and compared them with a model of pure pressure overload (M3, pulmonary artery banding) and a sham-operated group...
March 27, 2024: Basic Research in Cardiology
https://read.qxmd.com/read/38535113/incremental-value-of-biventricular-strain-in-patients-with-severe-aortic-stenosis
#2
JOURNAL ARTICLE
Camille Sarrazyn, Xavier Galloo, Maria Chiara Meucci, Steele C Butcher, Kensuke Hirsawa, Rinchyenkhand Myagmardorj, Frank van der Kley, Tine De Backer, Jeroen J Bax, Nina Ajmone Marsan
(1) Background: Left ventricular global longitudinal (LVGLS) and right ventricular free wall strain (RVFWS) demonstrated separate prognostic values in patients with severe aortic stenosis (AS). However, studies evaluating the combined assessment of LVGLS and RVFWS have shown contradictory results. This study explored the prognostic value of combining LVGLS and RVFWS in a large group of severe AS patients referred for transcatheter aortic valve implantation. (2) Methods: Patients were classified into three groups: preserved (LVGLS ≥ 15% AND RVFWS > 20%), single-ventricle impaired (LVGLS < 15% OR RVFWS ≤ 20%), or biventricular-impaired strain group (LVGLS < 15% AND RVFWS ≤ 20%)...
March 13, 2024: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/38535107/objective-quantification-of-bilateral-bubble-contrast-echocardiography-correlates-with-systemic-oxygenation-in-patients-with-single-ventricle-circulation
#3
JOURNAL ARTICLE
Ashley Phimister, Chana Bushee, Monica Merbach, Sai Alekha Challa, Amy Y Pan, Andrew D Spearman
Bubble contrast echocardiography is commonly used to diagnose pulmonary arteriovenous malformations (PAVMs) in single ventricle congenital heart disease (CHD), yet previous studies inconsistently report a correlation between bubble echoes and oxygenation. In this study, we sought to re-evaluate the correlation between bubble echoes and oxygenation by assessing total bilateral shunting and unilateral shunting. We conducted a single-center, retrospective study of patients with single ventricle CHD and previous Glenn palliation who underwent a cardiac catheterization and bubble echocardiogram during the same procedure from 2011 to 2020...
March 1, 2024: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/38535102/prophylactic-pulmonary-artery-banding-in-pediatric-dilated-cardiomyopathy-an-additional-therapeutic-option
#4
JOURNAL ARTICLE
Elena Panaioli, Diala Khraiche, Margaux Pontailler, Flavie Ader, Olivier Raisky, Regis Gaudin, Damien Bonnet
Dilated cardiomyopathy (DCM) is the most common childhood cardiomyopathy and is associated with considerable early mortality. Heart transplantation is often the only viable life-saving option. Pulmonary artery banding (PAB) has been recently proposed as a bridge or alternative to transplantation for DCM. In our cohort, PAB was selectively addressed to heritable DCM or DCM with congenital left ventricle aneurysm (CLVA). This study aimed to describe the clinical evolution and left ventricle reverse remodeling (LVRR) over time (6 months and 1 year after surgery)...
February 27, 2024: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/38535084/novel-biomarkers-in-evaluating-cardiac-function-in-patients-on-hemodialysis-a-pilot-prospective-observational-cohort-study
#5
JOURNAL ARTICLE
Lazar Chisavu, Viviana Mihaela Ivan, Adelina Mihaescu, Flavia Chisavu, Oana Schiller, Luciana Marc, Flaviu Bob, Adalbert Schiller
Chronic kidney disease patients treated by hemodialysis present a high cardiovascular morbidity and mortality. There is an imperative need for novel biomarkers for identifying these patients and to offer possible therapeutically interventions. We performed a prospective observational cohort study on 77 patients in the period of October 2021-October 2023. We measured serum plasma levels of interleukin 1-beta, galectin 3, human suppression of tumorigenicity factor 2, bone morphogenetic protein 2 and fibroblastic growth factor 23 at the inclusion site...
March 21, 2024: Diagnostics
https://read.qxmd.com/read/38535015/congenital-heart-defects-in-patients-with-molecularly-confirmed-sotos-syndrome
#6
JOURNAL ARTICLE
Giulio Calcagni, Federica Ferrigno, Alessio Franceschini, Maria Lisa Dentici, Rossella Capolino, Lorenzo Sinibaldi, Chiara Minotti, Alessia Micalizzi, Viola Alesi, Antonio Novelli, Anwar Baban, Giovanni Parlapiano, Domenico Coviello, Paolo Versacci, Carolina Putotto, Marcello Chinali, Fabrizio Drago, Andrea Bartuli, Bruno Marino, Maria Cristina Digilio
Sotos syndrome is an autosomal dominant condition characterized by overgrowth with advanced bone age, macrodolicocephaly, motor developmental delays and learning difficulties, and characteristic facial features caused by heterozygous pathogenetic variants in the NSD1 gene located on chromosome 5q35. The prevalence of heart defects (HDs) in individuals with Sotos syndrome is estimated to be around 15-40%. Septal defects and patent ductus arteriosus are the most commonly diagnosed malformations, but complex defects have also been reported...
March 11, 2024: Diagnostics
https://read.qxmd.com/read/38534766/low-salt-diet-regulates-the-metabolic-and-signal-transduction-genomic-fabrics-and-remodels-the-cardiac-normal-and-chronic-pathological-pathways
#7
JOURNAL ARTICLE
Dumitru A Iacobas, Haile Allen, Sanda Iacobas
Low-salt diet (LSD) is a constant recommendation to hypertensive patients, but the genomic mechanisms through which it improves cardiac pathophysiology are still not fully understood. Our publicly accessible transcriptomic dataset of the left ventricle myocardium of adult male mice subjected to prolonged LSD or normal diet was analyzed from the perspective of the Genomic Fabric Paradigm. We found that LSD shifted the metabolic priorities by increasing the transcription control for fatty acids biosynthesis while decreasing it for steroid hormone biosynthesis...
March 12, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534426/effects-of-aging-and-nerve-growth-factor-on-neuropeptide-expression-and-cholinergic-innervation-of-the-rat-basolateral-amygdala
#8
JOURNAL ARTICLE
Pedro A Pereira, Marta Tavares, Miguel Laires, Bárbara Mota, Maria Dulce Madeira, Manuel M Paula-Barbosa, Armando Cardoso
The basolateral amygdala (BLA) contains interneurons that express neuropeptide Y (NPY) and vasoactive intestinal polypeptide (VIP), both of which are involved in the regulation of functions and behaviors that undergo deterioration with aging. There is considerable evidence that, in some brain areas, the expression of NPY and VIP might be modulated by acetylcholine. Importantly, the BLA is one of the brain regions that has one of the densest cholinergic innervations, which arise mainly from the basal forebrain cholinergic neurons...
February 28, 2024: Biology
https://read.qxmd.com/read/38534004/first-in-man-right-atrial-appendage-implantation-of-a-micra-leadless-pacemaker
#9
Pauline Pinon, Laurence Iserin, Fatma Hachem, Victor Waldmann
INTRODUCTION: Pacemaker implantation can be challenging in patients with congenital heart disease. METHODS AND RESULTS: In a patient with Ebstein disease and symptomatic sinus node dysfunction, despite multiple attempts, the Micra® pacemaker could not be implanted in the severely dilated right ventricle. In that context, and after iodine injection to confirm the appropriate location, the Micra® pacemaker was successfully implanted in the right appendage at the first attempt...
March 27, 2024: Journal of Cardiovascular Electrophysiology
https://read.qxmd.com/read/38533951/impact-of-an-impaired-maternal-fetal-environment-on-death-in-children-with-congenital-heart-defects-undergoing-surgery-in-denmark-from-1994-to-2018
#10
JOURNAL ARTICLE
Rasmus Kristensen, Camilla Omann, Charlotte K Ekelund, J William Gaynor, Vibeke E Hjortdal
BACKGROUND: Studies show that an impaired maternal-fetal environment (iMFE) increases the mortality risk in children with single-ventricle congenital heart defects (CHDs). We investigated the impact of an iMFE on death in children with various surgically corrected CHDs. METHODS AND RESULTS: In this nationwide register-based study, we examined the association between an iMFE (including preeclampsia, gestational hypertension, gestational diabetes, maternal smoking during pregnancy) and death in a large cohort of children with surgically corrected CHDs in Denmark (1994-2018)...
March 27, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38533147/osteopathic-approach-in-the-stimulation-of-the-endocannabinoid-system-a-case-report
#11
Caterina Buonomini, Oliviero Bonetti, Emanuele Novelli
The endocannabinoid system is an important neuromodulatory system responsible for maintaining homeostasis in the biological system. Similarly, the autonomic nervous system is important to control involuntary bodily functions such as thermoregulation, regulation of heart rate and sleep latency. The endocannabinoid system and the autonomic nervous system can be modified by osteopathic manipulative techniques. In this report, we present a case of a 53-year-old patient with comorbidities, habitual cannabis use, and disorders associated with the endocannabinoid system and autonomic nervous system, on whom the cranial technique of the fourth ventricle (CV4) was performed...
February 2024: Curēus
https://read.qxmd.com/read/38532811/acute-effect-in-mechanical-efficiency-by-pressure-volume-loop-analysis-after-transcatheter-aortic-valve-implantation
#12
JOURNAL ARTICLE
Shen-Che Lin, Chih-Yao Chiang, Jung-Cheng Hsu, Jih-Hsin Huang, Jer-Shen Chen, Kuan-Ming Chiu
BACKGROUND: This study aimed to evaluate the immediate effect of transcatheter aortic valve implantation (TAVI) on mechanical efficiency. METHODS: A total of 46 patients (25 females) with an average age of 83 ± 6.4 years underwent TAVI using the CoreValve system. During the same hospitalization, we conducted a comprehensive comparison of the patients before and after TAVI without inotropic support using echocardiography. The parameters encompassed left ventricular (LV) geometry, valvular load, global LV afterload and ventricular hemodynamics...
March 2024: Acta Cardiologica Sinica
https://read.qxmd.com/read/38532293/how-to-protect-the-right-ventricle-in-hypoplastic-left-heart-syndrome
#13
JOURNAL ARTICLE
Shunji Sano
No abstract text is available yet for this article.
March 26, 2024: European Journal of Cardio-thoracic Surgery
https://read.qxmd.com/read/38532049/right-ventricular-injury-in-patients-with-covid-19-related-ards-eligible-for-ecmo-support-a-multicenter-retrospective-study
#14
JOURNAL ARTICLE
Matthieu Petit, Misylias Bouaoud, Edouard Jullien, Adrien Joseph, Bruno Evrard, Cyril Charron, Anousone Daulasim, Annick Legras, Maeva Gourraud, Marine Goudelin, Philippe Vignon, Antoine Vieillard-Baron
BACKGROUND: Coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome (ARDS) is associated with high mortality. Extracorporeal membrane oxygenation (ECMO) has been proposed in this setting, but optimal criteria to select target patients remain unknown. Our hypothesis is that evaluation of right ventricular (RV) function could be helpful. The aims of our study were to report the incidence and outcomes of patients eligible for ECMO according to EOLIA criteria, and to identify a subgroup of patients with RV injury, which could be a target for ECMO...
March 26, 2024: Annals of Intensive Care
https://read.qxmd.com/read/38531640/-initial-characterization-of-a-transgenic-mouse-with-overexpression-of-the-human-h-1-histamine-receptor-on-the-heart
#15
JOURNAL ARTICLE
Lina Maria Rayo Abella, Hannes Jacob, Max Keller, Lisa Schindler, Steffen Pockes, Sebastian Pitzl, Jan Klimas, Katarina Hadova, Sarah Schneider, Igor B Buchwalow, CongYu Jin, Pertti Panula, Uwe Kirchhefer, Joachim Neumann, Ulrich Gergs
There is controversy whether H1 -histamine receptors increase or decrease contractility in the mammalian heart. Therefore, we have generated mice that overexpress the human H1 -histamine receptor in the heart (H1 -TG). We hypothesized that histamine would either increase or decrease force of contraction and beating rate compared to littermate wild type mice (WT). In H1 -TG mice, we ascertained the presence of H1 -histamine receptors by autoradiography of atrium and ventricle using [3 H]mepyramine. The messenger RNA for human H1 -histamine-receptors was present in cardiac samples from H1 -TG and absent from WT...
March 26, 2024: Journal of Pharmacology and Experimental Therapeutics
https://read.qxmd.com/read/38531333/long-term-impact-of-left-bundle-branch-block-on-cardiopulmonary-exercise-test-variables-and-left-ventricular-systolic-function-a-two-stage-observational-study
#16
Alícia Caine Melo Santos, Enaldo Vieira de Melo, Antônio Carlos Sobral Sousa, Joselina Luzia Menezes Oliveira, Paulo Ricardo Martins-Filho, Nathalia Costa Macedo Noronha, Carmem Isaura Salles do Nascimento, Milena Dos Santos Barros Campos
INTRODUCTION: Left bundle branch block (LBBB) disrupts the electrical activation of the left ventricle (LV), potentially impairing its systolic function, leading to LBBB-induced cardiomyopathy. This study examined cardiopulmonary exercise test (CPET) variables in patients with and without LBBB and assessed the longitudinal development of left ventricular ejection fraction (LVEF). METHOD: An observational, comparative clinical study was executed in two stages at a private hospital in Brazil...
March 26, 2024: Cardiology
https://read.qxmd.com/read/38531080/immunocompetent-isolated-cerebral-mucormycosis-presenting-with-obstructive-hydrocephalus-illustrative-case
#17
JOURNAL ARTICLE
Khoa N Nguyen, Lindsey M Freeman, Timothy H Ung, Steven Ojemann, Fabio Grassia
BACKGROUND: Isolated cerebral mucormycosis is rare in immunocompetent adults and is only sparsely reported to be associated with obstructive hydrocephalus. OBSERVATIONS: Here, the authors report a case of obstructive hydrocephalus secondary to central nervous system mucormycosis without other systems or rhino-orbital involvement and its technical surgical management. A 23-year-old, incarcerated, immunocompetent patient with history of intravenous (IV) drug use presented with syncope...
March 25, 2024: J Neurosurg Case Lessons
https://read.qxmd.com/read/38530963/impact-of-birth-weight-to-placental-weight-ratio-and-other-perinatal-risk-factors-on-left-ventricular-dimensions-in-newborns-a-prospective-cohort-analysis
#18
JOURNAL ARTICLE
Ashraf Gad, Dhafer Malouche, Manoj Chhabra, Danthanh Hoang, Debbie Suk, Nitin Ron, Beata Dygulska, Madhu B Gudavalli, Ali M Nadroo, Pramod Narula, Ibrahim Elmakaty
OBJECTIVES: To investigate the association between birth weight to placental weight (BW/PW) ratio, and echocardiographic left ventricle (LV) morphology at birth, while accounting for other relevant perinatal factors. METHODS: A prospective cohort study was conducted on neonates at NewYork-Presbyterian Brooklyn Methodist Hospital from 2014 to 2018, categorized by their BW/PW percentile. Missing data were imputed with principal component analysis. Chi-squared and one-way analysis of variance were used to compare BW/PW groups and the best regression model was selected using a genetic and backward stepwise algorithm...
March 27, 2024: Journal of Perinatal Medicine
https://read.qxmd.com/read/38529483/a-computational-study-of-right-ventricular-mechanics-in-a-rat-model-of-pulmonary-arterial-hypertension
#19
JOURNAL ARTICLE
Oscar O Odeigah, Ethan D Kwan, Kristen M Garcia, Henrik Finsberg, Daniela Valdez-Jasso, Joakim Sundnes
Pulmonary arterial hypertension (PAH) presents a significant challenge to right ventricular (RV) function due to progressive pressure overload, necessitating adaptive remodeling in the form of increased wall thickness, enhanced myocardial contractility and stiffness to maintain cardiac performance. However, the impact of these remodeling mechanisms on RV mechanics in not clearly understood. In addition, there is a lack of quantitative understanding of how each mechanism individually influences RV mechanics...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38528818/the-effect-of-glucagon-like-peptide-1-receptor-agonists-on-cardiac-function-and-structure-in-patients-with-or-without-type-2-diabetes-mellitus-an-updated-systematic-review-and-meta-analysis
#20
JOURNAL ARTICLE
Yu Zhang, Danning Yang, Qiufeng Jia, Jie Yan, Fengshuang An
AIMS: To conduct an updated systematic review and meta-analysis to evaluate the efficacy of glucagon-like peptide-1 receptor agonists (GLP-1RAs) with regard to cardiac function and structure in people with or without type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: We conducted a systematic search using the PubMed, Embase and ClinicalTrials.gov online databases. The primary outcome of interest was changes in mitral inflow E-velocity to tissue Doppler e' velocity (E/e') ratio...
March 26, 2024: Diabetes, Obesity & Metabolism
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