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Karolina Kupczynska, Blazej W Michalski, Dawid Miskowiec, Jaroslaw D Kasprzak, Ewa Szymczyk, Paulina Wejner Mik, Piotr Lipiec
PURPOSE: To assess the potential ability of two-dimensional speckle tracking analysis (STE) during atrial fibrillation (AF) to identify patients with LA appendage thrombi (LAAT). METHODS: This study involved 93 patients with AF (39% female, 67.1 ± 9.5 years) who were referred for a clinical indication for transesophageal echocardiography (TEE). TEE revealed LAAT in 39 (42%) patients. We analyzed standard parameters of the left ventricle (LV) and LA in transthoracic echocardiography...
April 24, 2018: Echocardiography
Yoshio Takei, Noriko Nemoto, Toru Kameya, Hideaki Tamaki, Osamu Katsumata, Susumu Hyodo, Makoto Kusakabe
Atrial and B-type natriuretic peptides (ANP and BNP) are cardiac hormones important for cardiovascular and body fluid regulation. In some teleost species, an additional member of the natriuretic peptide family, ventricular NP (VNP), has been identified. In this study, we examine tissue distribution of these three NPs in the eel heart. Quantitative real-time PCR showed that anp is almost exclusively expressed in atria, bnp equally in atria and ventricles and vnp three-fold more in ventricles than in atria. The amount of bnp transcript overall in the heart was 1/10 those of anp and vnp...
April 25, 2018: Cell and Tissue Research
Mehwish Waseem, Naveed Yaqoob, Muhammad Iqbal Tariq, Muhammad Qasim Raza, Imran Amjad
OBJECTIVE: To determine the effect of lower limb ergometric training on echocardiographic parameters of left ventricle in dilated cardiomyopathy (DMC) patients. STUDY DESIGN: Randomized control trial. PLACE AND DURATION OF STUDY: Rawalpindi Institute of Cardiology, Rawalpindi, Pakistan, from September 2016 to February 2017. METHODOLOGY: Clinically stable patients with DCM (n=60), were randomly allocated into an interventional group with two-month interventional program and a non-trained control group (n=30 each)...
May 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
A Kotini, T Birbilis, P Anninos, I Seimenis
A 82-year-old male experiencing headaches, dementia, urinary incontinence and gait instability was diagnosed with normal pressure hydrocephalus (NPH) and underwent a resting state magnetoencephalography (MEG) examination. MEG data were recorded in a magnetically shielded room with a whole-head 122 channel biomagnetometer. Following MEG, a ventriculoperitoneal (VP) shunt was placed in his head and greatly improved his symptomatology. Spontaneous MEG recordings revealed lower magnetic fields at frontal and frontotemporal regions compared to central and posterior regions...
April 18, 2018: Journal of Integrative Neuroscience
Thomas Beez, Daniel Remmel, Hans-Jakob Steiger
Space-occupying tumor bed cysts have been reported after resection of intracranial tumors, although the exact mechanism of their pathogenesis is unclear. Opening of the ventricular system during the tumor resection appears to be a risk factor. Occlusion of the surgical opening of the ventricle using fibrinogen-coated collagen fleece has been suggested to restore the integrity of the ventricular system. Here we present a clinical image depicting an iatrogenic valve mechanism caused by a fleece intended to seal a surgical opening of the lateral ventricle, leading to development of a space-occupying tumor bed cyst and cerebrospinal fluid fistula...
April 21, 2018: World Neurosurgery
Lance D Wilson, Isabelle Deschenes
No abstract text is available yet for this article.
April 21, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Susan Taylor, Tricia Francisco, Janet A Munroe, Hadyn T Williams
Extracardiac uptake on SPECT MPI, seen with physiologic radiotracer distribution, benign or malignant neoplasm, infection, inflammation, or granulomatous disease, may confound the accuracy of MPI or lead to unsuspected pathology. A 38-year-old woman with end-stage renal disease on hemodialysis had SPECT MPI for renal transplant preoperative risk stratification, showing left anterior descending artery ischemia and an intense extracardiac soft tissue focus adjacent to the diaphragmatic right ventricle concerning for focal infection related to prior coronary or gastric surgeries or tumor...
April 23, 2018: Clinical Nuclear Medicine
Tamara Tesic, Jasmina Boban, Mladen Bjelan, Aleksandar Todorovic, Dusko Kozic, Snezana Brkic
Conventional magnetic-resonance (MR) imaging is not sensitive enough in depicting subtle neurodegenerative changes that occur during chronic HIV infection with good peripheral viral suppression. The aim of this study was to compare brain volumes in HIV-positive subjects with age- and education-matched healthy controls with regard to influence of aging and immunologic parameters. An overall of 65 subjects (40 HIV-positive and 25 age-, gender-, and education-matched healthy subjects) underwent conventional MR imaging with three-dimensional sequence adequate for volumetric measurements...
April 23, 2018: Journal of Neurovirology
Saurabh Sinha, Elizabeth Culpin, John McMullan
Endoscopic-assisted approaches have been shown to be a suitable alternative to the standard microscopic approach to pineal region tumours. With extension laterally into the ventricles, the 0° endoscope and microscope have significant limitations. We describe the extended endoscopic supracerebellar infratentorial (EESI) approach using angled endoscopes for a complex pineal region tumour that extended into the lateral ventricle. A 15-year-old boy presented with headaches and ataxia. MRI revealed a pineal region tumour extending into the lateral ventricle...
April 23, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Selcuk Pala, Munevver Sari, Gokhan Kahveci, Elnur Alizade, Ugur Arslantas, Abdulkadir Uslu
Objective: The aim of the study was to determine an association between the plasma YKL-40 level and echocardiographic left ventricle systolic and diastolic function parameters in patients with acute myocardial infarction. Subjects and Methods: The study included 46 patients with acute myocardial infarction. Serum brain natriuretic protein (BNP) and YKL-40 levels were analyzed on admission and after one month. Left ventricle systolic and diastolic functions and Tei index were computed by transthoracic echocardiography...
2018: Cardiology Research and Practice
Giovanna Ponti, Alice Farinetti, Marilena Marraudino, GianCarlo Panzica, Stefano Gotti
The forebrain ventricular-subventricular zone (V-SVZ) continuously generates new neurons throughout life. Neural stem cells (type B1 cells) along the lateral ventricle become activated, self-renew, and give rise to proliferating precursors which progress along the neurogenic lineage from intermediate progenitors (type C cells) to neuroblasts (type A cells). Neuroblasts proliferate and migrate into the olfactory bulb and differentiate into different interneuronal types. Multiple factors regulate each step of this process...
2018: Frontiers in Endocrinology
Sandeep S Sodhi, Tony J Zhang, Rachel McDonald, Vanessa Al Rashida, Nitin Kondapalli, Philip Barger, Philip Ludbrook, Ari M Cedars
Ventricular dysfunction is common among patients with repaired cyanotic congenital heart disease. To date, no pharmacologic intervention has been demonstrated to be beneficial in this setting. To begin addressing this knowledge gap, we conducted a single-center prospective, randomized, open-label pilot study to investigate the effects of eplerenone on serologic markers of collagen turnover and inflammation, 6-minute walk distance, and quality of life in patients with tetralogy of Fallot (TOF) or transposition of the great arteries with a systemic right ventricle (transposition of the great arteries [TGA])...
January 2018: Proceedings of the Baylor University Medical Center
Amal Abdussalam Ali A Hmaid, Milica Markelic, Vesna Otasevic, Sava Masovic, Aleksandra Jankovic, Bato Korac, Aleksandra Korac
Structural changes affecting cardiomyocyte function may contribute to the pathophysiological remodeling underlying cardiac function impairment. Recent reports have shown that endogenous nitric oxide (NO) plays an important role in this process. In order to examine the role of NO in cardiomyocyte remodeling, male rats were acclimated to room temperature (22 ± 1 °C) or cold (4 ± 1 °C) and treated with 2.25% l-arginine·HCl or 0.01% l-NAME (Nω -nitro-l-arginine methyl ester)·HCl for 45 days. Untreated groups served as controls...
March 2018: Saudi Journal of Biological Sciences
Tiankai Li, Xiaowei Zhang, Heng-Jie Cheng, Zhi Zhang, Sarfaraz Ahmad, Jasmina Varagic, Weimin Li, Che Ping Cheng, Carlos M Ferrario
BACKGROUND: Angiotensin-(1-12) [Ang-(1-12)] is a chymase-dependent source for angiotensin II (Ang II) cardiac activity. The direct contractile effects of Ang-(1-12) in normal and heart failure (HF) remain to be demonstrated. We assessed the hypothesis that Ang-(1-12) may modulate [Ca2+ ]i regulation and alter cardiomyocyte contractility in normal and HF rats. METHODS AND RESULTS: We compared left ventricle (LV) myocyte contractile and calcium transient ([Ca2+ ]iT ) responses to angiotensin peptides in 16 SD rats with isoproterenol-induced HF and 16 age-matched controls...
April 20, 2018: International Journal of Cardiology
Chantal Attard, Joanna Huang, Paul Monagle, Vera Ignjatovic
The Fontan procedure has transformed the lives of children born with single-ventricle physiology, previously deemed inoperable. Worldwide, there are an increasing number of children with Fontan circulation, with the potential for survival into adulthood. Due to the abnormal circulation, Fontan patients have an increased risk of thromboembolic (TE) events, with up to 25% of events leading to death. Despite the importance of preventing TE events in this patient population, there is currently no clinical consensus on the optimal monitoring, thromboprophylaxis therapies, and treatment of these events...
April 14, 2018: Thrombosis Research
Bettina Baeßler, Manoj Mannil, David Maintz, Hatem Alkadhi, Robert Manka
PURPOSE: To test in a first proof-of-concept study whether texture analysis (TA) allows for the detection of myocardial tissue alterations in hypertrophic cardiomyopathy (HCM) on non-contrast T1-weighted cardiac magnetic resonance (CMR) images using machine learning based approaches. METHODS: This retrospective, IRB-approved study included 32 patients with known HCM. Thirty patients with normal CMR served as controls. Regions-of-interest for TA encompassing the left ventricle were drawn on short-axis non-contrast T1-weighted images using a freely available software package...
May 2018: European Journal of Radiology
Olga Rafikova, Anup Srivastava, Ankit A Desai, Ruslan Rafikov, Stevan P Tofovic
BACKGROUND: Pulmonary arterial hypertension (PAH) is a fatal disease; however, the mechanisms directly involved in triggering and the progression of PAH are not clear. Based on previous studies that demonstrated a possible role of mitochondrial dysfunction in the pathogenesis of PAH, we investigated the effects of chronic inhibition of mitochondrial function in vivo in healthy rodents. METHODS: Right ventricle systolic pressure (RVSP) was measured in female rats at baseline and up to 24 days after inhibition of mitochondrial respiratory Complex III, induced by Antimycin A (AA, 0...
April 23, 2018: Respiratory Research
A Shams, J Hung, A Bahl
Patients with submassive pulmonary embolism (PE) resulting in right heart strain (RHS) have an increased risk of mortality compared to those with a preserved right ventricular function. This study aimed to investigate the predictive value of computed tomography pulmonary angiogram (CTPA) findings of right heart strain in patients with computed tomography (CT)-proven PE for the diagnosis of right heart strain by echocardiogram (ECHO). The institutional review board (IRB) approved retrospective chart review of the adult emergency department patients diagnosed with an acute PE between 2012 and 2016...
March 2018: Journal of Biological Regulators and Homeostatic Agents
Matthew J O'Connor, Andrew C Glatz, Joseph W Rossano, Robert E Shaddy, Rachel Ryan, Chitra Ravishankar, Stephanie Fuller, Christopher E Mascio, J William Gaynor, Kimberly Y Lin
BACKGROUND: Risk assessment in heart transplantation is critical for candidate selection, but current models inadequately assess individual risk of postoperative mortality. We sought to identify risk factors and develop a scoring system to predict mortality following heart transplantation in children. METHODS: The records of patients undergoing heart transplantation at our institution from 2010 - 2016 were reviewed. Clinical characteristics were recorded and compared between survivors and non-survivors...
April 20, 2018: Annals of Thoracic Surgery
Richard D Mainwaring, Tatiana R Rosenblatt, William L Patrick, Michael Ma, Lynn Peng, Frank L Hanley
BACKGROUND: There are patients born with pulmonary atresia and a ductus arteriosus or hemi-truncus to one lung and major aortopulmonary collateral arteries (MAPCAs) to the contralateral lung. The purpose of this study was to review our surgical results for this relatively rare subset of patients. METHODS: This was a retrospective review of 35 patients with ductus/hemi-truncus in association with pulmonary atresia with ventricular septal defect and MAPCAs. Our surgical algorithm is bifurcated into two strategies: 1) patients with "favorable" MAPCAs are candidates for single stage complete repair, and 2) patients with "unfavorable" MAPCAs undergo a staged approach...
April 20, 2018: Annals of Thoracic Surgery
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