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https://www.readbyqxmd.com/read/29616070/the-rice-rolled-fine-striped-rfs-chd3-mi-2-chromatin-remodeling-factor-epigenetically-regulates-genes-involved-in-oxidative-stress-responses-during-leaf-development
#1
Sung-Hwan Cho, Chung-Hee Lee, Eunji Gi, Yehyun Yim, Hee-Jong Koh, Kiyoon Kang, Nam-Chon Paek
In rice ( Oryza sativa ), moderate leaf rolling increases photosynthetic competence and raises grain yield; therefore, this important agronomic trait has attracted much attention from plant biologists and breeders. However, the relevant molecular mechanism remains unclear. Here, we isolated and characterized Rolled Fine Striped ( RFS ), a key gene affecting rice leaf rolling, chloroplast development, and reactive oxygen species (ROS) scavenging. The rfs-1 gamma-ray allele and the rfs-2 T-DNA insertion allele of RFS failed to complement each other and their mutants had similar phenotypes, producing extremely incurved leaves due to defective development of vascular cells on the adaxial side...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29615503/genomic-analysis-of-a-pan-resistant-isolate-of-klebsiella-pneumoniae-united-states-2016
#2
Tom J B de Man, Joseph D Lutgring, David R Lonsway, Karen F Anderson, Julia A Kiehlbauch, Lei Chen, Maroya Spalding Walters, Maria Sjölund-Karlsson, J Kamile Rasheed, Alexander Kallen, Alison Laufer Halpin
Antimicrobial resistance is a threat to public health globally and leads to an estimated 23,000 deaths annually in the United States alone. Here, we report the genomic characterization of an unusual Klebsiella pneumoniae , nonsusceptible to all 26 antibiotics tested, that was isolated from a U.S. PATIENT: The isolate harbored four known beta-lactamase genes, including plasmid-mediated bla NDM-1 and bla CMY-6 , as well as chromosomal bla CTX-M-15 and bla SHV-28 , which accounted for resistance to all beta-lactams tested...
April 3, 2018: MBio
https://www.readbyqxmd.com/read/29579836/early-bacterial-pneumonia-after-hepatic-transplantation-epidemiologic-profile
#3
J Prieto Amorin, M Lopez, K Rando, J Castelli, J Medina Presentado
BACKGROUND: Postoperative pulmonary complications are major cause of morbidity and mortality in patients receiving liver transplantation (LT), particularly bacterial pneumonia occurring within the first 100 days after transplantation. Our aim in this study was to determine the incidence, microorganisms involved, associated factors, and morbidity of bacterial pneumonia presenting in the first 100 days posttransplant. METHODS: We performed a cohort study in which patients receiving liver transplantation were included prospectively in our national database (Database of Infections in Transplantation of Solid Organs)...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29564870/-nosocomial-infections-caused-by-multiresistant-pseudomonas-aeruginosa-carbapenems-included-predictive-and-prognostic-factors-a-prospective-study-2016-2017
#4
A Hernández, G Yagüe, E García Vázquez, M Simón, L Moreno Parrado, M Canteras, J Gómez
OBJECTIVE: Pseudomonas aeruginosa is one of the major pathogens causing hospital-acquired infections. In recent years, antimicrobial resistance is increasing and multidrug resistant (MDR) and extremely drug resistant (XDR) isolates have been associated with an increase of mortality. The aim of this study is to assess the clinical significance and analyze predictors and prognostic factors. METHODS: Prospective case-control non-paired study involving 64 patients with P...
March 21, 2018: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/29561592/synthesis-of-the-death-cap-mushroom-toxin-%C3%AE-amanitin
#5
Kaveh Matinkhoo, Alla Pryyma, Mihajlo Todorovic, Brian O Patrick, David M Perrin
α-Amanitin is an extremely toxic bicyclic octapeptide isolated from the death-cap mushroom, Amanita phalloides. As a potent inhibitor of RNA polymerase II, α-amanitin is toxic to eukaryotic cells. Recent interest in α-amanitin arises from its promise as a payload for antibody-drug conjugates. For over 60 years, A. phalloides has been the only source of α-amanitin. Here we report a synthesis of α-amanitin, which surmounts the key challenges for installing the 6-hydroxy-tryptathionine sulfoxide bridge, enantioselective synthesis of (2 S,3 R,4 R)-4,5-dihydroxy-isoleucine, and diastereoselective sulfoxidation...
March 21, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29558258/environmental-factors-and-suicide-in-australian-farmers-a-qualitative-study
#6
Meg Perceval, Kairi Kõlves, Victoria Ross, Prasuna Reddy, Diego De Leo
Farmers and farm workers have been recognised as a group at high risk of suicide in Australia. This study aims to identify and better understand environmental factors associated with suicide among Australian farmers and farm workers. Qualitative analysis was undertaken in accordance with the Consolidated Criteria for Reporting Qualitative Research. Male and female focus groups were conducted separately with people who lived or worked on a farm in six farming communities. Qualitative analyses showed that a number of environmental influences may contribute to the increased risk of suicide: extreme climatic events; isolation; service availability; access to, and frequent use of firearms; death and suffering of animals; government and legislation; technology; and property values...
March 20, 2018: Archives of Environmental & Occupational Health
https://www.readbyqxmd.com/read/29532939/diagnostic-accuracy-and-clinical-outcomes-associated-with-prenatal-diagnosis-of-fetal-absent-cavum-septi-pellucidi
#7
Rachel A Pilliod, David R Pettersson, Thomas Gibson, Ladawna Gievers, Amanda Kim, Roya Sohaey, Karen Y Oh, Brian L Shaffer
BACKGROUND: Absence of the CSP on prenatal imaging is historically associated with additional anomalies, however recently cases of isolated, absent CSP have also been identified. This study seeks to assess the accuracy of prenatal imaging in evaluating isolated, absent CSP and to describe the spectrum of clinical outcomes. METHODS: This is a retrospective observational study of all prenatally diagnosed absent CSP cases between 2011 and 2016 at our institution. Cases with additional structural parenchymal abnormalities were excluded...
March 13, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29532545/an-asparagus-polysaccharide-fraction-inhibits-mdscs-by-inducing-apoptosis-through-toll-like-receptor-4
#8
Wensheng Zhang, Wanzhuo He, Xiaodong Shi, Xiao Li, Yuanyuan Wang, Minghua Hu, Fangli Ma, Ning Tao, Guiqin Wang, Zhihai Qin
Despite decades of research, malignant tumors are extremely difficult to eliminate with conventional methods. Although surgical resection potentially eradicates the problem, only a few cases are suitable for operation, and other approaches often involve harmful consequences. Revolutionary methods are desperately needed to improve patient outcomes and diminish harmful side effects. Myeloid-derived suppressor cells (MDSCs), downregulators of the innate and adaptive immune systems, have been widely studied over the past 2 decades...
March 13, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29472357/plerixafor-enables-the-safe-rapid-efficient-mobilization-of-haematopoietic-stem-cells-in-sickle-cell-disease-patients-after-exchange-transfusion
#9
Chantal Lagresle-Peyrou, François Lefrère, Elisa Magrin, Jean-Antoine Ribeil, Oriana Romano, Leslie Weber, Alessandra Magnani, Hanem Sadek, Clémence Plantier, Aurélie Gabrion, Brigitte Ternaux, Tristan Félix, Chloé Couzin, Aurélie Stanislas, Jean-Marc Tréluyer, Lionel Lamhaut, Laure Joseph, Marianne Delville, Annarita Miccio, Isabelle André-Schmutz, Marina Cavazzana
Sickle cell disease is characterized by chronic anaemia and vaso-occlusive crises, which eventually lead to multi-organ damage and premature death. Haematopoietic stem cell transplantation is the only curative treatment but it is limited by toxicity and poor availability of HLA-compatible donors. A gene therapy approach based on the autologous transplantation of lentiviral-corrected haematopoietic stem and progenitor cells was shown to be efficacious in one patient. However, alterations of the bone marrow environment and the red blood cells' properties hamper the harvesting and immunoselection of patient stem cells from bone marrow...
February 22, 2018: Haematologica
https://www.readbyqxmd.com/read/29468609/comparative-performance-of-the-7th-and-8th-editions-of-the-american-joint-committee-on-cancer-staging-systems-for-soft-tissue-sarcoma-of-the-trunk-and-extremities
#10
Sarah B Fisher, Yi-Ju Chiang, Barry W Feig, Janice N Cormier, Kelly K Hunt, Keila E Torres, Christina L Roland
BACKGROUND: The 8th edition American Joint Committee on Cancer (AJCC) staging for soft tissue sarcomas of the trunk/extremities divides T stage into four categories and upstages nodal disease to stage IV. We used the National Cancer Database (NCDB) to evaluate the prognostic power of the new system. METHODS: A total of 26,144 patients were identified from the NCDB from 2004 to 2013. Overall survival (OS) was compared using Kaplan-Meier and Cox proportional hazard models...
February 21, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29389234/duration-of-anti-programmed-death-1-therapy-in-advanced-melanoma-how-much-of-a-good-thing-is-enough
#11
Nikhil I Khushalani
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice...
February 1, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29369937/antifungal-susceptibility-and-clinical-outcome-in-neonatal-candidiasis
#12
Julie Autmizguine, Sylvia Tan, Michael Cohen-Wolkowiez, C Michael Cotten, Nathan Wiederhold, Ronald N Goldberg, Ira Adams-Chapman, Barbara J Stoll, P Brian Smith, Daniel K Benjamin
BACKGROUND: Invasive candidiasis is an important cause of sepsis in extremely low birth weight infants (ELBW, <1000g), is often fatal, and frequently results in neurodevelopmental impairment (NDI) among survivors. We sought to assess the antifungal minimum inhibitory concentration (MIC) distribution for Candida in ELBW infants and evaluate the association between antifungal resistance and death or NDI. METHODS: This was a secondary analysis of the NICHD Neonatal Research Network study, "Early Diagnosis of Nosocomial Candidiasis"...
January 24, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29341963/role-of-the-anesthesiologist-intensivist-outside-the-icu-opportunity-to-add-value-for-the-hospital-or-an-unnecessary-distraction
#13
Suzanne Bennett, Erin Grawe, Courtney Jones, Sean A Josephs, Maggie Mechlin, William E Hurford
PURPOSE OF REVIEW: Given the extremely expensive nature of critical care medicine, it seems logical that intensivists should play an active role in designing efficient systems of care. The true value of intensivists, however, is not well defined. RECENT FINDINGS: Anesthesiologists have taken key roles in improving patient safety in the operating room. Anesthesia-related mortality rates have decreased from 20 deaths per 100 000 anesthetics in the early 1980s to less than one death per 100 000 currently...
April 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29329995/multifunctional-hybrid-graphene-oxide-for-circulating-tumor-cell-isolation-and-analysis
#14
Avijit PramaniK, Stacy Jones, Ye Gao, Carrie Sweet, Aruna Vangara, Salma Begum, Paresh Chandra Ray
Even in 21st century, >90% cancer-associated deaths are caused by metastatic disease. Circulating tumor cells (CTCs), which circulate in the blood stream after release from primary tumors, extravasate and form fatal metastases in different organs. Several clinical trials indicate that CTCs can be used as a liquid biopsy of tumors for early diagnosis of cancers. Since CTCs are extremely rare and exhibit heterogeneous biology due to epithelial-mesenchymal transition (EMT), oncologists continue to face enormous challenges in using CTCs as a true "liquid biopsy" for cancer patients...
January 10, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29212693/clinical-functional-and-radiological-outcomes-of-extracorporeal-irradiation-in-limb-salvage-surgery-for-bone-tumours
#15
C W Jones, J Shatrov, J M Jagiello, S Millington, A Hong, R Boyle, P D Stalley
AIMS: We present a retrospective review of patients treated with extracorporeally irradiated allografts for primary and secondary bone tumours with the mid- and long-term survivorship and the functional and radiographic outcomes. PATIENTS AND METHODS: A total of 113 of 116 (97.4%) patients who were treated with extracorporeally irradiated allografts between 1996 and 2014 were followed up. Forms of treatment included reconstructions, prostheses and composite reconstructions, both with and without vascularised grafts...
December 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/29178878/trypsin-independent-porcine-epidemic-diarrhea-virus-us-strain-with-altered-virus-entry-mechanism
#16
Yunjeong Kim, Changin Oh, Vinay Shivanna, Richard A Hesse, Kyeong-Ok Chang
BACKGROUND: Porcine Epidemic Diarrhea Virus (PEDV) is a coronavirus that infects the intestinal tract and causes diarrhea and vomiting in older pigs or extreme dehydration and death that could reach 100% mortality in neonatal piglets. In the US, the first PEDV outbreaks occurred in 2013 and since then US PEDV strains have quickly spread throughout the US and worldwide, causing significant economic and public health concerns. Currently two conditionally approved vaccines exist in the US, but there is no live attenuated vaccine, which is considered the best option in controlling PEDV by inducing transferrable mucosal immunity to susceptible neonatal piglets...
November 25, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29174834/a-systematic-review-and-meta-analysis-of-the-management-and-outcomes-of-isolated-skull-fractures-in-children
#17
REVIEW
Silvia Bressan, Luca Marchetto, Todd W Lyons, Michael C Monuteaux, Stephen B Freedman, Liviana Da Dalt, Lise E Nigrovic
STUDY OBJECTIVE: Most studies of children with isolated skull fractures have been relatively small, and rare adverse outcomes may have been missed. Our aim is to quantify the frequency of short-term adverse outcomes of children with isolated skull fractures. METHODS: PubMed, EMBASE, the Cochrane Library, Scopus, Web of Science, and gray literature were systematically searched to identify studies reporting on short-term adverse outcomes of children aged 18 years or younger with linear, nondisplaced, isolated skull fractures (ie, without traumatic intracranial injury on neuroimaging)...
November 23, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29167149/three-dimensional-imaging-reveals-endo-sarco-plasmic-reticulum-containing-invaginations-within-the-nucleoplasm-of-muscle
#18
Shin-Haw Lee, Sina Hadipour-Lakmehsari, Tetsuaki Miyake, Anthony O Gramolini
The mammalian nucleus has invaginations from the cytoplasm, termed nucleoplasmic reticulum (NR). With increased resolution of cellular imaging, progress has been made in understanding the formation and function of NR. In fact, nucleoplasmic Ca2+ homeostasis has been implicated in the regulation of gene expression, DNA repair, and cell death. However, the majority of studies focus on cross-sectional or single-plane analyses of NR invaginations, providing an incomplete assessment of its distribution and content...
March 1, 2018: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29153067/-detection-of-influenza-virus-infections-by-molecular-and-immunofluorescence-methods
#19
Deniz Yıldırım, Deniz Özdoğru Sağdıç, Buket Şeflek, Mehmet Çimentepe, İbrahim Bayram, Fügen Yarkın
Influenza virus infections are extremely important for human health due to the occurence of seasonal epidemics and pandemics worldwide. Influenza is associated with high morbidity and may result in serious complications such as life threatening viral or bacterial pneumonia. Especially, young children, older adults, patients with chronic diseases such as heart, lung, kidney, and diabetes and immunosuppressed people are at higher risk for complications and death from influenza virus infections. The aim of this study was to determine the incidence of influenza type A and B virus infections and influenza A virus subtypes in hospitalized patients with respiratory tract infections by real-time reverse transcriptase-polymerase chain reaction (RT-PCR, Sacace, Italy), conventional RT-PCR and direct immunofluorescence antibody (DFA, Argene SA, France) tests...
October 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29140637/hazard-identification-and-risk-assessment-for-improving-farm-safety-on-canadian-farms
#20
Hassan S Chattha, Kenneth W Corscadden, Qamar U Zaman
Agriculture is one of the most hazardous industries worldwide. The number of serious accidents on farms, despite sophisticated technology, development of effective prevention methods, and high-quality training and improved skill levels of farmers, is still very high. The purpose of this study was to develop and apply a generic farm safety protocol to hazards that have been identified in previously published literature and demonstrate the potential benefits of such a protocol with a view to raising awareness of farm safety...
July 31, 2017: Journal of Agricultural Safety and Health
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