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https://www.readbyqxmd.com/read/27862043/pulmonary-vein-isolation-with-the-cryoballoon-technique-feasibility-procedural-outcomes-and-adoption-in-the-real-world-data-from-one-shot-technologies-to-pulmonary-vein-isolation-1stop-project
#1
Luigi Padeletti, Antonio Curnis, Claudio Tondo, Maurizio Lunati, Stefano Porcellini, Roberto Verlato, Luigi Sciarra, Gaetano Senatore, Domenico Catanzariti, Loira Leoni, Maurizio Landolina, Pietro Delise, Saverio Iacopino, Paolo Pieragnoli, Giuseppe Arena
BACKGROUND: Catheter ablation (CA) is recommended for patients with drug refractory symptomatic atrial fibrillation (AF). "One Shot" catheters have been introduced to simplify CA and cryoballoon-ablation (CBA) is spreading rapidly. Few real-world data are available on standard clinical practice, mainly from single center experience. We aimed to evaluate clinical settings, demographics and acute procedural outcomes in a large cohort of patients treated with CBA. METHODS: 903 patients (73% male, mean age 59±11) underwent pulmonary veins CBA...
November 10, 2016: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/27803840/experiences-and-psychosocial-impact-of-west-africa-ebola-deployment-on-us-health-care-volunteers
#2
Robyn Gershon, Liza A Dernehl, Ezinne Nwankwo, Qi Zhi, Kristine Qureshi
BACKGROUND:  This qualitative study was designed to assess health care volunteers' experiences and psychosocial impacts associated with deployment to the West Africa Ebola epidemic. METHODS: In 2015, using snowball sampling, 16 US health care volunteers who had recently returned from West Africa were recruited for this study. Semi-structured interviews were conducted to collect information associated with each phase of deployment (pre, peri, and post). RESULTS: Participants reported that they were motivated to volunteer because of a sense of responsibility and feelings of empathy and altruism...
September 21, 2016: PLoS Currents
https://www.readbyqxmd.com/read/27783991/oncolytic-vaccinia-virus-combined-with-radiotherapy-induces-apoptotic-cell-death-in-sarcoma-cells-by-down-regulating-the-inhibitors-of-apoptosis
#3
Michelle J Wilkinson, Henry G Smith, Gráinne McEntee, Joan Kyula-Currie, Tim D Pencavel, David C Mansfield, Aadil A Khan, Victoria Roulstone, Andrew J Hayes, Kevin J Harrington
Advanced extremity melanoma and sarcoma present a significant therapeutic challenge, requiring multimodality therapy to treat or even palliate disease. These aggressive tumours are relatively chemo-resistant, therefore new treatment approaches are urgently required. We have previously reported on the efficacy of oncolytic virotherapy (OV) delivered by isolated limb perfusion. In this report, we have improved therapeutic outcomes by combining OV with radiotherapy. In vitro, the combination of oncolytic vaccinia virus (GLV-1h68) and radiotherapy demonstrated synergistic cytotoxicity...
October 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/27753637/acute-toxicity-of-vildagliptin-differences-in-sensitivity-between-cynomolgus-monkeys-of-asian-or-mauritian-origin
#4
Peter Hoffmann, Lori Martin, Michael Keselica, Diane Gunson, Elizabeth Skuba, Dan Lapadula, Michael Hayes, Phil Bentley, Steve Busch
This article describes acute toxicity data in cynomolgus monkeys following oral treatment with vildagliptin, a dipeptidyl peptidase-4 inhibitor. Acute toxicity symptoms in cynomolgus monkeys include edema formation of the extremities, tails, and face associated with skeletal muscle necrosis, and elevations of lactate dehydrogenase, creatine kinase, alanine transaminase, and aspartate aminotransferase activities in the serum; hypothermia; hypotension; tachycardia; moribundity; and death in a few isolated instances...
October 17, 2016: Toxicologic Pathology
https://www.readbyqxmd.com/read/27679615/antimicrobial-activity-and-mechanism-of-inhibition-of-silver-nanoparticles-against-extreme-halophilic-archaea
#5
Rebecca S Thombre, Vinaya Shinde, Elvina Thaiparambil, Samruddhi Zende, Sourabh Mehta
Haloarchaea are salt-loving halophilic microorganisms that inhabit marine environments, sea water, salterns, and lakes. The resistance of haloarchaea to physical extremities that challenge organismic survival is ubiquitous. Metal and antibiotic resistance of haloarchaea has been on an upsurge due to the exposure of these organisms to metal sinks and drug resistance genes augmented in their natural habitats due to anthropogenic activities and environmental pollution. The efficacy of silver nanoparticles (SNPs) as a potent and broad spectrum inhibitory agent is known, however, there are no reports on the inhibitory activity of SNPs against haloarchaea...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27668288/single-nucleotide-polymorphisms-in-regulator-encoding-genes-have-an-additive-effect-on-virulence-gene-expression-in-a-vibrio-cholerae-clinical-isolate
#6
Bailey M Carignan, Kyle D Brumfield, Mike S Son
Vibrio cholerae is the etiological agent of the infectious disease cholera, which is characterized by vomiting and severe watery diarrhea. Recently, V. cholerae clinical isolates have demonstrated increased virulence capabilities, causing more severe symptoms with a much higher rate of disease progression than previously observed. We have identified single nucleotide polymorphisms (SNPs) in four virulence-regulatory genes (hapR, hns, luxO, and vieA) of a hypervirulent V. cholerae clinical isolate, MQ1795...
September 2016: MSphere
https://www.readbyqxmd.com/read/27617071/fournier-s-gangrene-in-a-neonate-with-acute-myeloid-leukemia-a-case-report
#7
Ziba Mosayebi, Ali Omidian, Amir Hossein Movahedian, Farzad Kompani, Seyyed Saeed Hosseininodeh
INTRODUCTION: Fournier's gangrene is an infective necrotizing fasciitis of external genital and perineal region. Hematologic malignancies and immunocompromised status are predisposing factors. Simultaneous occurrence of Fournier's gangrene and congenital leukemia in neonates is extremely rare. CASE PRESENTATION: We present a case of Fournier's gangrene in a 4-day-old female infant with a necrotic lesion in perineum and no history of trauma or other predisposing condition...
June 2016: Iranian Journal of Pediatrics
https://www.readbyqxmd.com/read/27516468/challenges-encountered-and-lessons-learnt-from-venous-injuries-at-sri-lankan-combat-theatres
#8
Amila Sanjiva Ratnayake, B Samarasinghe, M Bala
PURPOSE: The objective of this study was to characterise the spectrum of peripheral venous injury in the Sri Lankan war theatres, including categorisation of anatomic patterns, mechanism and management of casualties, including short-term results of surgical repair of traumatic venous injuries versus ligation. In addition, the effects and outcome of combined arterial and venous injuries versus arterial injury alone are compared. METHODS: All adults with extremity vascular injuries admitted to a military base hospital during an 8-month period were prospectively recorded and those with a venous injury were analysed...
August 11, 2016: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/27512331/extremes-of-shock-index-predicts-death-in-trauma-patients
#9
Stephen R Odom, Michael D Howell, Alok Gupta, George Silva, Charles H Cook, Daniel Talmor
CONTEXT: We noted a bimodal relationship between mortality and shock index (SI), the ratio of heart rate to systolic blood pressure. AIMS: To determine if extremes of SI can predict mortality in trauma patients. SETTINGS AND DESIGNS: Retrospective evaluation of adult trauma patients at a tertiary care center from 2000 to 2012 in the United States. MATERIALS AND METHODS: We examined the SI in trauma patients and determined the adjusted mortality for patients with and without head injuries...
July 2016: Journal of Emergencies, Trauma, and Shock
https://www.readbyqxmd.com/read/27497124/virulence-and-antibiotic-and-heavy-metal-resistance-of-vibrio-parahaemolyticus-isolated-from-crustaceans-and-shellfish-in-shanghai-china
#10
Qiongxia Hu, Lanming Chen
Vibrio parahaemolyticus can cause serious human seafoodborne gastroenteritis and even death. In this study, we isolated and characterized 208 V. parahaemolyticus strains from 10 species of commonly consumed crustaceans and shellfish available in fish markets in Shanghai, People's Republic of China, in 2014. Most of these aquatic species had not been detected previously. The results revealed an extremely low occurrence of pathogenic V. parahaemolyticus carrying the toxin gene trh (1.9%). However, a high level of resistance to the antibiotics ampicillin (94...
August 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/27490677/isolated-rectus-abdominis-metastasis-from-melanoma-an-extremely-rare-case
#11
Alberto Gómez Portilla, Anais Cruz, Nuria Juan, Palmira Malo, Eduardo López de Heredia, Maitane Larrañaga
INTRODUCTION: Melanoma is a health problem world-wide. Its incidence has tripled in the last decade. The main cause of death in melanoma patients is widespread metastases. It can metastasize to almost every organ. However, melanoma skeletal muscle metastases (MSMM) are exceptional, and only two cases of MSMM to rectus abdominis muscles have been previously published. Regardless of all new advances seen in melanoma therapy, cure for most MSMM is still elusive. Surgical approaches are still not well defined...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27466258/multiterritory-atherosclerosis-and-carotid-intima-media-thickness-as-cardiovascular-risk-predictors-after-percutaneous-angioplasty-of-symptomatic-subclavian-artery-stenosis
#12
Leszek Wrotniak, Anna Kablak-Ziembicka, Izabela Karch, Piotr Pieniazek, Agnieszka Rosławiecka, Szymon Mleczko, Lukasz Tekieli, Krzysztof Zmudka, Tadeusz Przewlocki
OBJECTIVES: To identify independent predictors of cardiovascular events among patients with subclavian artery stenosis. METHODS: Two hundred eighteen consecutive patients with subclavian artery stenosis referred to angioplasty were examined for coexistent coronary, renal, or lower extremity artery stenosis of 50% or greater. Initial carotid intima-media thickness and internal carotid artery (ICA) stenosis were assessed. Intima-media thickness was reassessed in 108 randomly chosen patients to evaluate the change over time...
September 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/27339800/results-of-treatment-of-lymphoblastic-lymphoma-at-the-children-cancer-hospital-egypt-a-single-center-experience
#13
Hany Abdel Rahman Sayed, Mohamed Sedky, Asmaa Hamoda, Naglaa El Kinaaie, Madeha El Wakeel, Dina Hesham
Introduction Lymphoblastic lymphoma (LBL) and acute lymphoblastic leukemia (ALL) are neoplasms of immature B or T-cell precursors. They are considered as a unique biological entity in the 2008 World Health Organization Classification of Hematologic Neoplasm. Both entities are arbitrarily separated by a cut-off point of 20-25% of blast cells in the bone marrow. Treatment of LBL has evolved over time from conventional high-grade NHL schedules to ALL-derived protocols. The aim of this work is to report the clinical characteristics, overall survival (OS), event free survival (EFS), and common chemotherapy toxicities of lymphoblastic lymphoma (LBL) patients during a 5...
September 2016: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/27264140/helping-families-cope-with-the-severe-stress-of-dravet-syndrome
#14
Peter Camfield, Carol Camfield, Kathleen Nolan
A child with Dravet syndrome shakes family life to the core. Dravet syndrome usually has three phases: (1) up to 1-1½ years: with episodes of febrile status epilepticus but normal development; (2) age 1½ to ~6-10 years: with frequent seizures of varying types, developmental stagnation, behavioural and sleep problems; (3) after ~10 years: improvement in seizures, deteriorating gait, intellectual disability but some developmental gains. Complete seizure control is rare-simply prescribing medication is inadequate to help families...
June 2016: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/27147942/multimodal-imaging-signatures-of-parkinson-s-disease
#15
F DuBois Bowman, Daniel F Drake, Daniel E Huddleston
Parkinson's disease (PD) is a complex neurodegenerative disorder that manifests through hallmark motor symptoms, often accompanied by a range of non-motor symptoms. There is a putative delay between the onset of the neurodegenerative process, marked by the death of dopamine-producing cells, and the onset of motor symptoms, creating an urgent need to develop biomarkers that may yield early PD detection. Neuroimaging offers a non-invasive approach to examining the potential utility of a vast number of functional and structural brain characteristics as biomarkers...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27111750/outcomes-are-worse-in-us-patients-undergoing-surgery-on-weekends-compared-with-weekdays
#16
Laurent G Glance, Turner Osler, Yue Li, Stewart J Lustik, Michael P Eaton, Richard P Dutton, Andrew W Dick
BACKGROUND: Increasing surgical access to previously underserved populations in the United States may require a major expansion of the use of operating rooms on weekends to take advantage of unused capacity. Although the so-called weekend effect for surgery has been described in other countries, it is unknown whether US patients undergoing moderate-to-high risk surgery on weekends are more likely to experience worse outcomes than patients undergoing surgery on weekdays. OBJECTIVE: The aim of this study was to determine whether patients undergoing surgery on weekends are more likely to die or experience a major complication compared with patients undergoing surgery on a weekday...
June 2016: Medical Care
https://www.readbyqxmd.com/read/27092555/recurrent-rare-genomic-copy-number-variants-and-bicuspid-aortic-valve-are-enriched-in-early-onset-thoracic-aortic-aneurysms-and-dissections
#17
Siddharth Prakash, Shao-Qing Kuang, Ellen Regalado, Dongchuan Guo, Dianna Milewicz
Thoracic Aortic Aneurysms and Dissections (TAAD) are a major cause of death in the United States. The spectrum of TAAD ranges from genetic disorders, such as Marfan syndrome, to sporadic isolated disease of unknown cause. We hypothesized that genomic copy number variants (CNVs) contribute causally to early onset TAAD (ETAAD). We conducted a genome-wide SNP array analysis of ETAAD patients of European descent who were enrolled in the National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC)...
2016: PloS One
https://www.readbyqxmd.com/read/27083906/antibiotic-and-heavy-metal-resistance-of-vibrio-parahaemolyticus-isolated-from-fresh-shrimps-in-shanghai-fish-markets-china
#18
Yu He, Lanlan Jin, Fengjiao Sun, Qiongxia Hu, Lanming Chen
Vibrio parahaemolyticus is a causative agent of human serious seafood-borne gastroenteritis disease and even death. Shrimps, often eaten raw or undercooked, are an important reservoir of the bacterium. In this study, we isolated and characterized a total of 400 V. parahaemolyticus strains from commonly consumed fresh shrimps (Litopenaeus vannamei, Macrobrachium rosenbergii, Penaeus monodon, and Exopalaemon carinicauda) in Shanghai fish markets, China in 2013-2014. The results revealed an extremely low occurrence of pathogenic V...
August 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27083249/surgical-management-of-sternoclavicular-joint-infections
#19
Stefan S Kachala, Desmond M D'Souza, Lucileia Teixeira-Johnson, Sudish C Murthy, Siva Raja, Eugene H Blackstone, Daniel P Raymond
BACKGROUND: Infections of the sternoclavicular joint (SCJ) respond poorly to nonoperative management and typically require resection. We examined presenting characteristics and outcomes after surgical management of SCJ infections, reviewing a 20-year single-institution experience. METHODS: From January 1992 to December 2012, 40 patients (age, 57 ± 12 years; 70% male) underwent resection of an infected SCJ. Sternal infections after cardiac surgery were excluded...
June 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27077848/comparison-of-topical-hemostatic-agents-in-a-swine-model-of-extremity-arterial-hemorrhage-bloodstop-ix-battle-matrix-vs-quikclot-combat-gauze
#20
Huixi Li, Lin Wang, Amjad Alwaal, Yung-Chin Lee, Amanda Reed-Maldonado, Taylor A Spangler, Lia Banie, Reginald B O'Hara, Guiting Lin
BloodSTOP iX Battle Matrix (BM) and QuikClot Combat Gauze (CG) have both been used to treat traumatic bleeding. The purpose of this study was to examine the efficacy and initial safety of both products in a swine extremity arterial hemorrhage model, which mimics combat injury. Swine (37.13 ± 0.56 kg, NBM = 11, NCG = 9) were anesthetized and splenectomized. We then isolated the femoral arteries and performed a 6 mm arteriotomy. After 45 s of free bleeding, either BM or CG was applied. Fluid resuscitation was provided to maintain a mean arterial pressure of 65 mmHg...
2016: International Journal of Molecular Sciences
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