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isolated extremity deaths

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https://www.readbyqxmd.com/read/28982710/identification-of-extremely-premature-infants-at-low-risk-for-early-onset-sepsis
#1
Karen M Puopolo, Sagori Mukhopadhyay, Nellie I Hansen, C Michael Cotten, Barbara J Stoll, Pablo J Sanchez, Edward F Bell, Abhik Das, Angelita M Hensman, Krisa P Van Meurs, Myra H Wyckoff
BACKGROUND: Premature infants are at high risk of early-onset sepsis (EOS) relative to term infants, and most are administered empirical antibiotics after birth. We aimed to determine if factors evident at birth could be used to identify premature infants at lower risk of EOS. METHODS: Study infants were born at 22 to 28 weeks' gestation in Neonatal Research Network centers from 2006 to 2014. EOS was defined by isolation of pathogenic species from blood or cerebrospinal fluid culture at ≤72 hours age...
October 5, 2017: Pediatrics
https://www.readbyqxmd.com/read/28901675/sudden-cardiac-death-in-isolated-right-ventricular-hypertrabeculation-noncompaction-cardiomyopathy
#2
Soad Bekheit, Boutros Karam, Farshid Daneshvar, Julie Zaidan, Rabih Tabet, Jonathan Spagnola, James Lafferty
Hypertrabeculation/noncompaction of the myocardium is a rare disorder that involves most commonly the left ventricle of the heart and it has been recognized as a distinct cardiomyopathy by the World Health Organization. However, it is extremely rare for this condition to involve exclusively the right ventricle. We report the cases of three patients who presented with ventricular tachyarrhythmia and sudden cardiac death. They were found to have isolated right ventricular hypertrabeculation/noncompaction on echocardiography...
September 12, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28883235/a-patient-with-hepatocellular-carcinoma-with-isolated-right-atrial-metastases
#3
Hiroaki Takaya, Hideto Kawaratani, Kenichiro Seki, Yasushi Okura, Mitsuteru Kitade, Tadashi Namisaki, Masayoshi Sawai, Yasuhiko Sawada, Takuya Kubo, Akira Mitoro, Junichi Yamao, Hitoshi Yoshiji
Hepatocellular carcinoma (HCC) with isolated right atrial metastasis is extremely rare; most cases are considered inoperable. We herein report the case of a 74-year-old man with HCC with isolated right atrial metastases without hepatic vein invasion; the right atrial lesion was resected because of the risk of heart failure and sudden death. Postoperatively, he underwent transcatheter arterial chemoembolization and radiofrequency ablation for intrahepatic HCC. He recovered completely, with a long-term survival of 36 months...
October 1, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28871623/clinical-course-of-patients-with-symptomatic-isolated-superficial-vein-thrombosis-the-icaro-follow-up-study
#4
S Barco, F Pomero, M N D Di Minno, E Tamborini Permunian, A Malato, S Pasca, G Barillari, L Fenoglio, S Siragusa, G Di Minno, W Ageno, F Dentali
Essentials Late sequelae of isolated superficial vein thrombosis (iSVT) have rarely been investigated. We studied 411 consecutive outpatients with acute iSVT with a median follow-up of three years. Male sex and cancer are risk factors for future deep vein thrombosis or pulmonary embolism. Patients without cancer appear to be at a negligible risk for death. SUMMARY: Background Studies of long-term thromboembolic complications and death following acute isolated superficial vein thrombosis (iSVT) of the lower extremities are scarce...
September 4, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28817714/insights-into-secular-trends-of-respiratory-tuberculosis-the-20th-century-maltese-experience
#5
Lianne Tripp, Larry A Sawchuk
Over half a century ago, McKeown and colleagues proposed that economics was a major contributor to the decline of infectious diseases, including respiratory tuberculosis, during the 19th and 20th centuries. Since then, there is no consensus among researchers as to the factors responsible for the mortality decline. Using the case study of the islands of Malta and Gozo, we examine the relationship of economics, in particular, the cost of living (Fisher index) and its relationship to the secular trends of tuberculosis mortality...
2017: PloS One
https://www.readbyqxmd.com/read/28659974/esophageal-cancer-metastases-to-unexpected-sites-a-systematic-review
#6
REVIEW
Osama Shaheen, Abdulaziz Ghibour, Bayan Alsaid
The most common pattern of esophageal cancer metastases (ECM) is to the lymph nodes, lung, liver, bones, adrenal glands, and brain. On the other hand, unexpected metastasis (UM) spread to uncommon sites has increasingly reported and consequently affected the pathway of diagnosis, staging, and management. Using the PubMed database, a systematic search of the following headings "Esophageal" and "Metastasis" or "Metastases" was performed, 10049 articles were identified, and the articles were included if they demonstrated unexpected ECM...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28649296/clinical-profile-and-outcome-of-diabetic-foot-ulcer-a-view-from-tertiary-care-hospital-in-semarang-indonesia
#7
Tjokorda Gde Dalem Pemayun, Ridho M Naibaho
Background: This study attempted to determine the disease burden in terms of clinical profile and outcome of diabetic foot ulcer (DFU) admissions at a tertiary care hospital in a developing country. Methods: In this descriptive study, the data were collected from the medical record of diabetic patients with foot ulcer who were treated in Dr. Kariadi General Hospital during a 3-year period. The demographic characteristic, type of foot lesion, etiology, isolated microorganism, treatment, and outcome were reviewed...
2017: Diabetic Foot & Ankle
https://www.readbyqxmd.com/read/28490487/bifidobacterium-bacteremia-clinical-characteristics-and-a-genomic-approach-to-assess-pathogenicity
#8
Eirin Esaiassen, Erik Hjerde, Jorunn Pauline Cavanagh, Gunnar Skov Simonsen, Claus Klingenberg
Bifidobacteria are commensals that colonize the orogastrointestinal tract and rarely cause invasive human infections. However, an increasing number of bifidobacterial blood culture isolates has lately been observed in Norway. In order to investigate the pathogenicity of the Bifidobacterium species responsible for bacteremia, we studied Bifidobacterium isolates from 15 patients for whom cultures of blood obtained from 2013 to 2015 were positive. We collected clinical data and analyzed phenotypic and genotypic antibiotic susceptibility...
July 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28451298/enrichment-and-single-cell-analysis-of-circulating-tumor-cells
#9
Yanling Song, Tian Tian, Yuanzhi Shi, Wenli Liu, Yuan Zou, Tahereh Khajvand, Sili Wang, Zhi Zhu, Chaoyong Yang
Up to 90% of cancer-related deaths are caused by metastatic cancer. Circulating tumor cells (CTCs), a type of cancer cell that spreads through the blood after detaching from a solid tumor, are essential for the establishment of distant metastasis for a given cancer. As a new type of liquid biopsy, analysis of CTCs offers the possibility to avoid invasive tissue biopsy procedures with practical implications for diagnostics. The fundamental challenges of analyzing and profiling CTCs are the extremely low abundances of CTCs in the blood and the intrinsic heterogeneity of CTCs...
March 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28429101/human-circulating-and-tissue-gastric-cancer-stem-cells-display-distinct-epithelial-mesenchymal-features-and-behaviors
#10
Shengliang Zhang, Yanna Shang, Tie Chen, Xin Zhou, Wengtong Meng, Chuanwen Fan, Ran Lu, Qiaorong Huang, Xue Li, Xu Hong, Zongguang Zhou, Jiankun Hu, Xianming Mo
INTRODUCTION: Metastasis is a leading cause of cancer-related-deaths worldwide. Recently, cancer stem cells (CSCs) have been believed to be responsible for tumor initiation and metastasis, but till now, difference of cellular features and behaviors between CSCs from tumor tissues (TCSCs) and circulation (CCSCs) remains largely unknown, which hinders the progression of targeted therapies for metastasis. METHODS AND RESULTS: Here, we provide the features of circulating gastric cancer stem cells (CGCSCs) isolated from human gastric adenocarcinoma...
April 20, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28364444/acute-type-a-dissection-in-octogenarians-does-emergency-surgery-impact-in-hospital-outcome-or-long-term-survival
#11
MULTICENTER STUDY
Julia Dumfarth, Sven Peterss, Maximilian Luehr, Christian D Etz, Thomas Schachner, Markus Kofler, Bulat A Ziganshin, Hanno Ulmer, Michael Grimm, John A Elefteriades, Friedrich W Mohr
Objectives: Surgical therapy for acute aortic dissection type A (AADA) in octogenarians carries high morbidity and mortality. The role of isolated medical treatment in this setting is controversial. The aim of this study is to determine whether risk of surgery for AADA outweighs risk of death from medical treatment only. Methods: From 2002 to 2015, 90 consecutive octogenarians (mean age, 83.5 ± 3 years) were treated for AADA at three institutions: 67 patients underwent surgery, 23 patients received medical treatment...
March 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28317814/the-medicinal-plants-in-the-control-of-tuberculosis-laboratory-study-on-medicinal-plants-from-the-northern-area-of-pakistan
#12
Sami Ullah, Shah Hussain, Sadiq Noor Khan, Mohammad Khurram, Iqbal Khan, Murad Ali Khan
BACKGROUND: Tuberculosis (TB) ranks as the second leading cause of deaths due to infectious diseases. Although global efforts have been made to control TB, still, this is a serious threat as Mycobacterium tuberculosis (MTB) produced resistance against both the first- and second-line drugs. The increasing incidence of multidrug-resistant, extremely drug resistant, and totally drug-resistant TB worldwide requires extra efforts to search for new anti-TB drugs. MATERIALS AND METHODS: The present study evaluated the antimycobacterial activities of Citrullus colocynthis, Calotropis procera, Ricinus communis, Capparis decidua, and Fagonia cretica plants' extracts against rifampicin-sensitive (H37Rv) and rifampicin-resistant (TMC331) strains of MTB...
January 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28284022/trypsin-specific-inhibitors-from-the-macrolepiota-procera-armillaria-mellea-and-amanita-phalloides-wild-mushrooms
#13
Tjaša Lukanc, Jože Brzin, Janko Kos, Jerica Sabotič
Wild growing mushrooms are a rich source of novel proteins with unique features. We have isolated and characterized trypsin inhibitors from two edible mushrooms, the honey fungus (Armillaria mellea) and the parasol mushroom (Macrolepiota procera), and from the poisonous death cap (Amanita phalloides). The trypsin inhibitors isolated: armespin, macrospin and amphaspin, have similar molecular masses, acidic isoelectric points and are not N-glycosylated. They are very strong trypsin inhibitors and weak chymotrypsin inhibitors...
2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/28258964/diagnosis-and-treatment-of-spontaneous-coronary-artery-pseudoaneurysm-rare-anomaly-with-potentially-significant-clinical-implications
#14
Subrata Kar, Richard R Webel
Spontaneous coronary artery pseudoaneurysm (PSA, false aneurysm) is an extremely rare occurrence with the precise incidence unknown. It is defined as an outwardly bulging monolayer or double layer within the coronary artery that lacks all 3 layers (intima, media, and adventitia) of the arterial wall. Coronary PSA commonly occurs from arterial dissection or perforation induced by catheter intervention, infection, pregnancy, or trauma. Traumatic dissection or perforation of the coronary artery after a percutaneous coronary intervention (PCI) remains the most common cause...
March 4, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28214485/outcome-of-peripheral-venous-reconstructions-during-tumor-resection
#15
Philip Y Sun, Mark D Fleming, Kendall Stauffer, Manju Kalra, Gustavo Oderich, Thomas Bower, Peter Gloviczki, Randall R DeMartino
OBJECTIVE: Peripheral venous reconstruction surgery may be necessary for appropriate oncologic resection; however, the operative approach and surgical outcomes are not well described. We report our experience with these complex reconstructions to identify best practice. METHODS: We retrospectively reviewed all adult patients who underwent peripheral vein reconstruction for tumor resection at Mayo Clinic, Rochester (2000-2015). Patients were classified into three subgroups by the location: iliac (IL), lower extremity (LE), and upper extremity (UE)...
March 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28190783/a-retrospective-analysis-of-catheter-based-sources-in-intravascular-brachytherapy
#16
J DeCunha, C Janicki, S A Enger
PURPOSE: Coronary artery disease involves the deposition of plaque along the walls of a coronary artery leading to narrowed or blocked vessels (stenosis) and is one of the main causes of death in developed countries. Percutaneous transluminal coronary angioplasty (PTCA) is used to reverse stenosis. Restenosis (renarrowing) of the treated vessel is a major complication of PTCA. A metal mesh tube (stent) can be placed inside the vessel to prevent restenosis. Tissue stress incurred during PTCA and stenting can provoke neointimal cell proliferation leading to in-stent restenosis (ISR)...
May 2017: Brachytherapy
https://www.readbyqxmd.com/read/28146458/moderate-hyperoxia-induces-inflammation-apoptosis-and-necrosis-in-human-umbilical-vein-endothelial-cells-an-in-vitro-study
#17
Christina Hafner, Jing Wu, Lourdes Soto-Gonzalez, Christoph Kaun, Stefan Stojkovic, Johann Wojta, Verena Tretter, Klaus Markstaller, Klaus U Klein
BACKGROUND: Perioperative oxygen (O2) therapy can cause hyperoxia. Extreme hyperoxia can injure the cardiovascular system and remote organs. OBJECTIVE: Our primary objective was to test the hypothesis that exposure to moderate hyperoxia will induce injury to human umbilical vein endothelial cells (HUVECs), a model for studying the vascular endothelium under controlled conditions. DESIGN: In-vitro cell culture study. SETTING: Department of Anaesthesia, General Intensive Care and Pain Management, Medical University of Vienna, Austria...
March 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/27994795/long-term-effects-of-untreated-adolescent-idiopathic-scoliosis-a-review-of-the-literature
#18
REVIEW
Hans-Rudolf Weiss, Nikos Karavidas, Marc Moramarco, Kathryn Moramarco
Currently, adolescent idiopathic scoliosis (AIS) is principally regarded as benign, but some researchers have cited serious or extreme effects, including severe pain, cardiopulmonary compromise, social isolation, and even early death. Therefore, exploration of the long-term effects of AIS, the most common type of idiopathic scoliosis, is warranted. The purpose of this review was to examine the long-term studies on the natural history of AIS and/or reviews concerning the long-term effects of untreated AIS. A PubMed search was conducted using the key words idiopathic scoliosis, long-term effects and idiopathic scoliosis, natural history...
December 2016: Asian Spine Journal
https://www.readbyqxmd.com/read/27938483/transplantation-of-mesenchymal-stromal-cells-in-patients-with-amyotrophic-lateral-sclerosis-results-of-phase-i-iia-clinical-trial
#19
Eva Syková, Petr Rychmach, Ivana Drahorádová, Šimona Konrádová, Kateřina Růžičková, Ivan Voříšek, Serhiy Forostyak, Aleš Homola, Martin Bojar
Amyotrophic lateral sclerosis (ALS) is a progressive untreatable neurodegenerative disorder, leading to the death of the cortical and spinal motoneurons (MNs). Bone marrow-derived mesenchymal stem/stromal cells (BM-MSCs) may represent a new approach to slowing down the progression of ALS by providing neurotrophic support to host MNs and by having an anti-inflammatory effect. We have designed a prospective, nonrandomized, open-label clinical trial (phase I/IIa, EudraCT No. 2011-000362-35) to assess the safety and efficacy of autologous multipotent BM-MSCs in ALS treatment...
April 13, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/27862043/pulmonary-vein-isolation-with-the-cryoballoon-technique-feasibility-procedural-outcomes-and-adoption-in-the-real-world-data-from-one-shot-technologies-to-pulmonary-vein-isolation-1stop-project
#20
Luigi Padeletti, Antonio Curnis, Claudio Tondo, Maurizio Lunati, Stefano Porcellini, Roberto Verlato, Luigi Sciarra, Gaetano Senatore, Domenico Catanzariti, Loira Leoni, Maurizio Landolina, Pietro Delise, Saverio Iacopino, Paolo Pieragnoli, Giuseppe Arena
BACKGROUND: Catheter ablation (CA) is recommended for patients with drug refractory symptomatic atrial fibrillation (AF). "One Shot" catheters have been introduced to simplify CA and cryoballoon ablation (CBA) is spreading rapidly. Few real-world data are available on standard clinical practice, mainly from single-center experience. We aimed to evaluate clinical settings, demographics, and acute procedural outcomes in a large cohort of patients treated with CBA. METHODS: A total of 903 patients (73% male, mean age 59 ± 11) underwent pulmonary vein CBA...
January 2017: Pacing and Clinical Electrophysiology: PACE
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