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https://www.readbyqxmd.com/read/29126178/the-impact-of-intradialytic-pedaling-exercise-on-arterial-stiffness-a-pilot-randomized-controlled-trial-in-a-hemodialysis-population
#1
Alexandra B Cooke, Vincent Ta, Sameena Iqbal, Yessica-Haydee Gomez, Thomas Mavrakanas, Paul Barré, Murray Vasilevsky, Elham Rahme, Stella S Daskalopoulou
Objectives: Regular exercise is known to reduce arterial stiffness (AS) in hemodialysis patients. However, the impact of a more realistic intradialytic form of exercise, such as pedaling, is unclear. We aimed to examine 1) the effect of intradialytic pedaling exercise on AS over 4 months, and 2) the longer-term effect of pedaling on AS 4 months after exercise cessation. Methods: Patients on stable in-center hemodialysis (3x/week) were randomly assigned 1:1 to either intradialytic pedaling exercise (EX) or to a control group receiving usual hemodialysis (nonEX) for 4 months...
November 6, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/29081017/validation-of-central-and-peripheral-non-invasive-hemodynamic-variables-using-an-oscillometric-method
#2
Darío Echeverri, Alejandro Pizano, Jaime Cabrales, Karen Moreno
INTRODUCTION: Peripheral and central blood pressures are parameters of arterial stiffness and important cardiovascular risk markers. Today, there are non-invasive methods that measure these pressures. AIM: To validate the non-invasive oscillometric method, compared with invasive pressure measurements obtained by cardiac catheterization. METHODS: An open, prospective cohort clinical study in 100 patients, 64 ± 11 years old. The measurement of peripheral and central blood pressures obtained using the Arteriograph(®) system oscillometric method, (TensioMed, Budapest-Hungary, Ltd...
October 28, 2017: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/29066449/effect-of-vitamin-d-supplementation-on-arterial-stiffness-and-central-blood-pressure-indexes-demystifying-the-evidence
#3
EDITORIAL
Pankaj Arora, Thomas J Wang
No abstract text is available yet for this article.
October 24, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29043559/nonfunctioning-adrenal-incidentaloma-affecting-central-blood-pressure-and-arterial-stiffness-parameters
#4
Tolga Akkan, Mustafa Altay, Yasemin Ünsal, Murat Dağdeviren, Esin Beyan
PURPOSE: Recently, cardiovascular risk is thought to be increased in patients with nonfunctioning adrenal incidentaloma (NFAI). There are no sufficient studies in the literature to evaluate this situation in NFAI patients without cardiovascular risk. The objective of this study is to compare peripheral and central blood pressure and arterial stiffness between patients with NFAI and healthy volunteers (of a similar age, gender and body mass index as the NFAI group) who have no traditional cardiovascular risk factors and autonomous cortisol secretion, with pulse wave analysis (PWA)...
October 17, 2017: Endocrine
https://www.readbyqxmd.com/read/29035941/arterial-stiffness-and-cardiometabolic-phenotype-of-cameroonian-pygmies-and-bantus
#5
William Ngatchou, Daniel Lemogoum, Christian Mélot, Virginie Guimfacq, Philippe van de Borne, Jean Claude Wautrecht, Michel P Hermans, Luc Van Bortel, Marc Leeman
BACKGROUND: Pygmies living in the Central African rainforest with a traditional hunter-gatherer lifestyle have a low incidence of cardiovascular diseases. Because of progressive loss of traditional habitat and ancestral lands, some Pygmies have migrated to urban areas and adopt specific Bantu lifestyles such as increased salt consumption and a sedentary way of life. We tested the hypothesis that migrant Pygmies could present with hemodynamic and metabolic characteristics different from those of traditional in-situ Pygmies and possibly closer to those of Bantu farmers...
October 13, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29018628/combined-moderate-and-high-intensity-exercise-with-dietary-restriction-improves-cardiac-autonomic-function-associated-with-a-reduction-in-central-and-systemic-arterial-stiffness-in-obese-adults-a-clinical-trial
#6
Min Hu, Shen Wang, Dan Wang, Qinhao Lai, Xiaoying Chen, Shiwei Duan, Mengke Zhao, Junhao Huang
OBJECTIVE: The present study aimed to assess the effects of exercise with dietary restriction on cardiac autonomic activity, arterial stiffness, and cardiovascular biomarkers in obese individuals. METHODS: Seventeen obese adults completed an 8-week exercise and dietary program. Anthropometry, body composition, and multiple biochemical markers were measured. We used carotid-femoral pulse wave velocity (cfPWV), brachial-ankle pulse wave velocity (baPWV), central blood pressure, and augmentation index (AIx) to assess arterial stiffness...
2017: PeerJ
https://www.readbyqxmd.com/read/28879040/comparison-of-effects-between-calcium-channel-blocker-and-diuretics-in-combination-with-angiotensin-ii-receptor-blocker-on-24-h-central-blood-pressure-and-vascular-hemodynamic-parameters-in-hypertensive-patients-study-design-for-a-multicenter-double-blinded
#7
Gyu Chul Oh, Hae-Young Lee, Wook Jin Chung, Ho-Joong Youn, Eun-Joo Cho, Ki-Chul Sung, Shung Chull Chae, Byung-Su Yoo, Chang Gyu Park, Soon Jun Hong, Young Kwon Kim, Taek-Jong Hong, Dong-Ju Choi, Min Su Hyun, Jong Won Ha, Young Jo Kim, Youngkeun Ahn, Myeong Chan Cho, Soon-Gil Kim, Jinho Shin, Sungha Park, Il-Suk Sohn, Chong-Jin Kim
BACKGROUND: Hypertension is a risk factor for coronary heart disease and stroke, and is one of the leading causes of death. Although over a billion people are affected worldwide, only half of them receive adequate treatment. Current guidelines on antihypertensive treatment recommend combination therapy for patients not responding to monotherapy, but as the number of pills increase, patient compliance tends to decrease. As a result, fixed-dose combination drugs with different antihypertensive agents have been developed and widely used in recent years...
2017: Clinical Hypertension
https://www.readbyqxmd.com/read/28864708/does-supplementation-with-carnosine-improve-cardiometabolic-health-and-cognitive-function-in-patients-with-pre-diabetes-and-type-2-diabetes-study-protocol-for-a-randomised-double-blind-placebo-controlled-trial
#8
Estifanos Baye, Kirthi Menon, Maximilian Pj de Courten, Arul Earnest, James Cameron, Barbora de Courten
INTRODUCTION: Carnosine, an over-the-counter food supplement, has a promising potential for the prevention and treatment of chronic diseases such as type 2 diabetes (T2DM), cardiovascular and neurodegenerative diseases through its anti-inflammatory, antiglycation, antioxidative and chelating effects. We have previously shown that supplementation with carnosine preserves insulin sensitivity and secretion in non-diabetic overweight and obese individuals. The effect of carnosine on cardiometabolic risk and related cognitive outcomes in patients with pre-diabetes and T2DM has thus far not been studied...
September 1, 2017: BMJ Open
https://www.readbyqxmd.com/read/28835849/the-impact-on-central-blood-pressure-and-arterial-stiffness-post-renal-denervation-in-patients-with-stage-3-and-4-chronic-kidney-disease-the-prairie-renal-denervation-study
#9
Bhanu Prasad, Jennifer Rose St Onge, Michelle C E McCarron, Kunal Goyal, Payam Dehghani
BACKGROUND: Central aortic blood pressures and arterial stiffness are better indicators of cardiovascular outcomes than brachial blood pressures. However, their response to renal denervation (RDN) in patients with stage 3 and stage 4 chronic kidney disease (CKD) has not yet been examined. OBJECTIVE: To evaluate the impact of RDN on central blood pressures, brachial (office and ambulatory) blood pressures, arterial stiffness, glomerular filtration rate (GFR), 24-hour urine protein, and selective cardiac parameters observed on echocardiograms...
2017: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/28830669/central-systolic-blood-pressure-and-aortic-stiffness-response-to-dietary-sodium-in-young-and-middle-aged-adults
#10
Bryce J Muth, Michael S Brian, Julio A Chirinos, Shannon L Lennon, William B Farquhar, David G Edwards
High dietary sodium intake can lead to hypertension and increased incidence of cardiovascular disease. We sought to determine the effect of short-term dietary sodium loading on central blood pressure and arterial stiffness in young (YG; 22-40 years) and middle-aged (MA; 41-60 years) normotensive adults. YG (n = 49; age: 27 ± 1 years) and MA (n = 36; age: 52 ± 1 years) subjects were randomized, in a cross-over design, to 7 days of low-sodium (LS; 20 mmol/d) or high-sodium (HS; 300 mmol/d) diet...
July 28, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28830251/the-effect-of-renal-denervation-on-arterial-stiffness-central-blood-pressure-and-heart-rate-variability-in-treatment-resistant-essential-hypertension-a-substudy-of-a-randomized-sham-controlled-double-blinded-trial-the-reset-trial
#11
Christian Daugaard Peters, Ole Norling Mathiassen, Henrik Vase, Jesper Bech Nørgaard, Kent Lodberg Christensen, Anne Pauline Schroeder, Hans Joachim von Hofe Rickers, Ulla Kampmann Opstrup, Per Løgstrup Poulsen, Sten Langfeldt, Gratien Andersen, Klavs Würgler Hansen, Hans Erik Bøtker, Morten Engholm, Jannik Buus Bertelsen, Erling Bjerregaard Pedersen, Anne Kaltoft, Niels Henrik Buus
OBJECTIVES: To investigate, whether renal denervation (RDN) improves arterial stiffness, central blood pressure (C-BP) and heart rate variability (HRV) in patients with treatment resistant hypertension. METHODS: ReSET was a randomized, sham-controlled, double-blinded trial (NCT01459900). RDN was performed by a single experienced operator using the Medtronic unipolar Symplicity Flex(TM) catheter. C-BP, carotid-femoral pulse wave velocity (PWV), and HRV were obtained at baseline and after six months with the SphygmoCor(®)-device...
August 23, 2017: Blood Pressure
https://www.readbyqxmd.com/read/28639151/central-arterial-function-measured-by-non-invasive-pulse-wave-analysis-is-abnormal-in-patients-with-duchenne-muscular-dystrophy
#12
Thomas D Ryan, John J Parent, Zhiqian Gao, Philip R Khoury, Elizabeth Dupont, Jennifer N Smith, Brenda Wong, Elaine M Urbina, John L Jefferies
Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder caused by mutation of dystrophin. Cardiovascular involvement includes dilated cardiomyopathy. Non-invasive assessment of vascular function has not been evaluated in DMD. We hypothesize arterial wave reflection is abnormal in patients with DMD. Pulse wave analysis was performed on DMD patients with a SphygmoCor SCOR-PVx System to determine central blood pressure and augmentation index (AIx) as an assessment of arterial wave reflection. Results were compared to a control group...
August 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28594710/twenty-four-hour-central-blood-pressure-is-not-better-associated-with-hypertensive-target-organ-damage-than-24-h-peripheral-blood-pressure
#13
Alejandro de la Sierra, Julia Pareja, Patricia Fernández-Llama, Pedro Armario, Sergi Yun, Eva Acosta, Francesca Calero, Susana Vázquez, Pedro Blanch, Cristina Sierra, Anna Oliveras
BACKGROUND AND AIM: Central blood pressure (BP) is increasingly considered as a better estimator of hypertension associated risks. We aimed to evaluate the association of 24-h central BP, in comparison with 24-h peripheral BP, with the presence of target organ damage (TOD). METHODS: Cross-sectional study of 208 hypertensive patients, aged 57 ± 12 years, 34% women. Office (mean of 4 measurements) and 24-h central and peripheral BP were measured by the oscillometric Mobil-O-Graph device...
June 7, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28590772/arterial-stiffness-in-fertile-women-with-metabolic-syndrome
#14
Tiina Vilmi-Kerälä, Teemu Koivistoinen, Outi Palomäki, Jukka Uotila, Ari Palomäki
INTRODUCTION: Although metabolic syndrome (MetS) is evidently associated with the risk of cardiovascular disease (CVD), recently its use has been questioned. We studied the utility of MetS diagnosis when estimating individual CVD risk. METHODS: We compared 27 fertile women with MetS and 27 counterparts without the syndrome, matched pairwise according to well-known risk factors of CVD. Pulse wave velocity (PWV) and central blood pressure (cBP) were determined noninvasively via a SphygmoCor device...
June 23, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28540933/the-effect-of-high-altitude-on-central-blood-pressure-and-arterial-stiffness
#15
C J Boos, E Vincent, A Mellor, D R Woods, C New, R Cruttenden, M Barlow, M Cooke, K Deighton, P Scott, S Clarke, J O'Hara
Central arterial systolic blood pressure (SBP) and arterial stiffness are known to be better predictors of adverse cardiovascular outcomes than brachial SBP. The effect of progressive high altitude (HA) on these parameters has not been examined. Ninety healthy adults were included. Central BP and the augmentation index (AI) were measured at the level of the brachial artery (Uscom BP(+) device) at <200 m and at 3619, 4600 and 5140 m. The average age of the subjects (70% men) were 32.2±8.7 years. Compared with central arterial pressures, brachial SBP (+8...
November 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/28538380/acute-effects-of-cinacalcet-on-arterial-stiffness-and-ventricular-function-in-hemodialysis-patients-a-randomized-double-blinded-crossover-study
#16
Aurélie Poulin, Pierre-Luc Bellemare, Catherine Fortier, Fabrice Mac-Way, Simon Desmeules, Karine Marquis, Valérie Gaudreault, Marcel Lebel, Mohsen Agharazii
BACKGROUND: Serum calcium concentration (Ca) plays an essential role in a vascular muscle tone and myocardial contractility. Previously, we showed that acutely lowering Ca by hemodialysis reduced arterial stiffness. Cinacalcet is a calcimimetic that lowers Ca and parathyroid hormone (PTH). The aim of the present study was to examine whether acute lowering of Ca by cinacalcet improves vascular stiffness and myocardial diastolic dysfunction. METHOD: This is a double-blinded randomized placebo-controlled crossover study that included 21 adult patients with end-stage kidney disease undergoing chronic hemodialysis...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28409014/comparable-effect-of-aliskiren-or-a-diuretic-added-on-an-angiotensin-ii-receptor-blocker-on-augmentation-index-in-hypertension-a-multicentre-prospective-randomised-study
#17
Toru Miyoshi, Takashi Murakami, Satoru Sakuragi, Masayuki Doi, Seiji Nanba, Atsushi Mima, Youkou Tominaga, Takafumi Oka, Yutaka Kajikawa, Kazufumi Nakamura, Hiroshi Ito
BACKGROUND: The effects of antihypertensive drug combination therapy on central blood pressure (BP) and augmentation index (AI) have not been fully elucidated. We investigated the effects of the direct renin inhibitor, aliskiren, or a diuretic added to an angiotensin II receptor blocker on AI in patients with essential hypertension. METHODS: A 24-week, prospective, multicentre, randomised, open-label study enrolled 103 patients already treated with valsartan. Participants were randomly allocated to receive either valsartan with aliskiren (V+A), or valsartan with trichlormethiazide (V+T)...
2017: Open Heart
https://www.readbyqxmd.com/read/28405891/renalase-in-children-with-glomerular-kidney-diseases
#18
Piotr Skrzypczyk, Joanna Przychodzień, Małgorzata Mizerska-Wasiak, Elżbieta Kuźma-Mroczkowska, Magdalena Okarska-Napierała, Elżbieta Górska, Anna Stelmaszczyk-Emmel, Urszula Demkow, Małgorzata Pańczyk-Tomaszewska
Studies suggest that renalase, a renal catecholamine-inactivating enzyme, plays a major role in the pathogenesis of kidney and cardiovascular diseases in adults. This study seeks to determine the role of renalase in children with glomerular kidney diseases. We evaluated the serum renalase, arterial stiffness, intima-media thickness, blood pressure, and clinical and biochemical parameters in 78 children (11.9 ± 4.6 years of age) with glomerulopathies such as idiopathic nephrotic syndrome (40 cases), IgA nephropathy (12 cases), Henoch-Schönlein nephropathy (12 cases), and other glomerulopathies (14 cases)...
April 13, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28364031/the-effect-of-acute-maximal-exercise-on-postexercise-hemodynamics-and-central-arterial-stiffness-in-obese-and-normal-weight-individuals
#19
Kanokwan Bunsawat, Sushant M Ranadive, Abbi D Lane-Cordova, Huimin Yan, Rebecca M Kappus, Bo Fernhall, Tracy Baynard
Central arterial stiffness is associated with incident hypertension and negative cardiovascular outcomes. Obese individuals have higher central blood pressure (BP) and central arterial stiffness than their normal-weight counterparts, but it is unclear whether obesity also affects hemodynamics and central arterial stiffness after maximal exercise. We evaluated central hemodynamics and arterial stiffness during recovery from acute maximal aerobic exercise in obese and normal-weight individuals. Forty-six normal-weight and twenty-one obese individuals underwent measurements of central BP and central arterial stiffness at rest and 15 and 30 min following acute maximal exercise...
April 2017: Physiological Reports
https://www.readbyqxmd.com/read/28256104/haemodynamic-influences-of-bisoprolol-in-hypertensive-middle-aged-men-a-double-blind-randomized-placebo-controlled-cross-over-study
#20
Lauri Suojanen, Antti Haring, Antti Tikkakoski, Jenni K Koskela, Anna M Tahvanainen, Heini Huhtala, Mika Kähönen, Kalle Sipilä, Arttu Eräranta, Jukka T Mustonen, Kari Kivistö, Ilkka H Pörsti
Treatment with beta-blockers appears to show inferior reduction in central versus peripheral blood pressure. We aimed to examine simultaneous changes in central and peripheral blood pressure, vascular resistance, cardiac function and arterial stiffness during beta-blockade. Haemodynamics were investigated after 3 weeks of bisoprolol treatment (5 mg/day) in a double-blind, randomized, placebo-controlled cross-over trial in never-treated 16 Caucasian males with grade I-II primary hypertension using continuous tonometric pulse wave analysis and whole-body impedance cardiography...
August 2017: Basic & Clinical Pharmacology & Toxicology
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