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https://www.readbyqxmd.com/read/29039794/heat-shock-protein-inducing-property-of-diarylheptanoid-containing-chalcone-moiety-from-alpinia-katsumadai
#1
Joo-Won Nam, Yun-Sil Lee
A new diarylheptanoid containing a chalcone moiety, katsumain H (1), was isolated from the seeds of Alpinia katsumadai. The structure was elucidated using a combination of 1D/2D NMR spectroscopy and mass spectrometry data analysis. The absolute configurations of C-3, C-5, and C-7 in 1 were assigned based on its optical rotation and after comparing its NMR chemical shifts with those of its diastereoisomers, katsumain E and katsumain F, which were previously isolated from this plant and characterized. In this study, the stimulatory effects of compounds 1 and 2 were evaluated on heat shock factor 1 (HSF1), heat shock protein 27 (HSP27), and HSP70...
October 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29037376/the-small-heat-shock-protein-hsp27-present-understanding-and-future-prospects
#2
REVIEW
Manish Kumar Singh, Bechan Sharma, Pramod K Tiwari
Heat shock proteins are important for maintaining protein homeostasis and cell survival. Among different classes of highly conserved Hsps, low molecular weight Hsps (sHsps) have significant place, particularly Hsp27, whose role has been demonstrated in wide range of biological processes, including development, immunity, diseases and therapy. In this review, the structure and functions of Hsp27 and related genes, their role in different cellular processes as well as in stress tolerance, is highlighted.
October 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29034430/ultraviolet-filters-and-heat-shock-proteins-effects-in-chironomus-riparius-by-benzophenone-3-and-4-methylbenzylidene-camphor
#3
Raquel Martín-Folgar, Mónica Aquilino, Irene Ozáez, José-Luis Martínez-Guitarte
Benzophenone-3 (BP3) and 4-methylbenzylidene camphor (4MBC) are common ultraviolet filters (UV filters), compounds considered as emergent contaminants, used in different products like plastics and personal care products. The levels of these compounds are rising in the wild, but the effects they have on invertebrates are poorly understood. Chironomus riparius is a benthic insect widely used in toxicology, and several studies have been previously performed in our laboratory to determine the effects these compounds have on this organism at the molecular level...
October 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28987880/heparin-functionalized-polymer-graft-surface-eluting-mk2-inhibitory-peptide-to-improve-hemocompatibility-and-anti-neointimal-activity
#4
Yunki Lee, Phuong Le Thi, Gyeung Mi Seon, Seung Bae Ryu, Colleen M Brophy, YongTae Kim, Jong-Chul Park, Ki Dong Park, Joyce Cheung-Flynn, Hak-Joon Sung
The leading cause of synthetic graft failure includes thrombotic occlusion and intimal hyperplasia at the site of vascular anastomosis. Herein, we report a co-immobilization strategy of heparin and potent anti-neointimal drug (Mitogen Activated Protein Kinase II inhibitory peptide; MK2i) by using a tyrosinase-catalyzed oxidative reaction for preventing thrombotic occlusion and neointimal formation of synthetic vascular grafts. The binding of heparin-tyramine polymer (HT) onto the polycarprolactone (PCL) surface enhanced blood compatibility with significantly reduced protein absorption (64...
October 4, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28987163/cellular-reactions-of-the-central-nervous-system
#5
Gabor G Kovacs
Major cell types of the central nervous system comprise neurons, glial cells (astrocytes, oligodendrocytes, ependymal cells, and microglia), choroid plexus cells, cells related to blood vessels and coverings. These cells show a wide range of reactions to various noxious agents, which can be detected in routine stainings. Some of these reactions are nonspecific to different injuries; however some, such as the appearance of inclusion bodies, can be highly disease-specific. Immunohistochemical markers are widely used in neuropathologic diagnostic practice and help to understand the pathogenesis of diseases...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28980915/functional-role-of-inflammation-in-the-surgical-injury-induced-vascular-remodeling-of-male-albino-rats
#6
X Song, L Li, Y Wu, L Zhang, X Li
Our present study investigates the cellular and molecular inflammatory events in male albino rat arterial injury. Male albino rats were subjected to longitudinal incision and carotid artery clamping for the duration of 45 days. Heat shock protein (HSP) 27, HSP70, HSP47 and Nuclear Factor kappa B (NF-κB) expressions were determined by qPCR and Western blot method. The morphology of vessel wall alteration was studied by the light microscopy. The expression of NF-κB was found to be increased after ten days of carotid artery injury...
September 30, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28979146/clinicopathological-significance-of-hsp27-in-gastric-cancer-a-meta-analysis
#7
REVIEW
Hua Ge, Xueyan He, Lingfei Guo, Xianzhi Yang
BACKGROUND: Many studies have provided increasing evidence to demonstrate that HSP27 has been involved in the development of gastric cancer; however, they all include few patients and the results remain controversial. Hence, we conducted a meta-analysis to evaluate correlations between HSP27 and the clinicopathological characteristics of gastric cancer. METHODS: An electronic search for relevant articles was conducted in PubMed, Cochrane Library, Web of Science, EMBASE database, Chinese CNKI, and Wan Fang...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28977718/sustained-cell-body-reactivity-and-loss-of-neun-in-a-subset-of-axotomized-bulbospinal-neurons-after-a-chronic-high-cervical-spinal-cord-injury
#8
Fannie Darlot, Stéphane Vinit, Valéry Matarazzo, Anne Kastner
Following central nervous system lesion, the ability of injured axons to regrowth may depend on the level and duration of the injured cell body response (CBR). Therefore, in order to investigate whether axotomized brainstem neurons maintain a durable growth-competent state after spinal cord injury, we studied the effect of a chronic C2 hemisection in rats on the expression of various CBR markers involved in axon regeneration, such as c-Jun, ATF-3, HSP27, NO synthase (NOS), and also of the neural mature phenotype marker NeuN, in the bulbospinal respiratory neurons as compared to the Gigantocellularis nucleus...
October 4, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28972920/disrupting-effects-of-antibiotic-sulfathiazole-on-developmental-process-during-sensitive-life-cycle-stage-of-chironomus-riparius
#9
Kiyun Park, Ihn-Sil Kwak
Antibiotics in the environment are a concern due to their potential to harm humans and interrupt ecosystems. Sulfathiazole (STZ), a sulfonamide antibiotic, is commonly used in aquaculture and is typically found in aquatic ecosystems. We evaluated the ecological risk of STZ by examining biological, molecular and biochemical response in Chironomus riparius. Samples were exposed to STZ for 12, 24 and 96 h, and effects of STZ were evaluated at the molecular level by analyzing changes in gene expression related to the endocrine system, cellular stress response and enzyme activity of genes on antioxidant and detoxification pathways...
September 26, 2017: Chemosphere
https://www.readbyqxmd.com/read/28971978/activation-of-the-sweet-taste-receptor-t1r3-by-the-artificial-sweetener-sucralose-regulates-the-pulmonary-endothelium
#10
Elizabeth O Harrington, Alexander Vang, Julie Braza, Aparna Shil, Havovi Chichger
A hallmark of acute respiratory distress syndrome (ARDS) is pulmonary vascular permeability. In these settings, loss of barrier integrity is mediated by cell-contact disassembly and actin-remodelling. Studies into molecular mechanisms responsible for improving microvascular barrier function are therefore vital in the development of therapeutic targets for reducing vascular permeability in ARDS. The sweet taste receptor, T1R3 is a GPCR, activated following exposure to sweet molecules, to trigger a gustducin-dependent signal cascade...
September 28, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28969372/novel-insights-in-the-disease-biology-of-mutant-small-heat-shock-proteins-in-neuromuscular-diseases
#11
Elias Adriaenssens, Thomas Geuens, Jonathan Baets, Andoni Echaniz-Laguna, Vincent Timmerman
Small heat shock proteins are molecular chaperones that exert diverse cellular functions. To date, mutations in the coding regions of HSPB1 (Hsp27) and HSPB8 (Hsp22) were reported to cause distal hereditary motor neuropathy and Charcot-Marie-Tooth disease. Recently, the clinical spectrum of HSPB1 and HSPB8 mutations was expanded to also include myopathies. Here we provide an update on the molecular genetics and biology of small heat shock protein mutations in neuromuscular diseases.
October 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28961845/borealis-1-a-randomized-first-line-placebo-controlled-phase-ii-study-evaluating-apatorsen-and-chemotherapy-for-patients-with-advanced-urothelial-cancer
#12
J Bellmunt, B J Eigl, E Senkus, Y Loriot, P Twardowski, D Castellano, N Blais, S S Sridhar, C N Sternberg, M Retz, S Pal, B Blumenstein, C Jacobs, P S Stewart, D P Petrylak
Background: Five-year survival of patients with inoperable, advanced urothelial carcinoma treated with the first-line chemotherapy is 5%-15%. We assessed whether the Hsp27 inhibitor apatorsen combined with gemcitabine plus cisplatin (GC) could improve overall survival (OS) in these patients. Patients and methods: This placebo-controlled, double-blind, phase II trial randomized 183 untreated urothelial carcinoma patients (North America and Europe) to receive GC plus either placebo (N = 62), 600 mg apatorsen (N = 60), or 1000 mg apatorsen (N = 61)...
October 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28943453/titin-isoforms-are-increasingly-protected-against-oxidative-modifications-in-developing-rat-cardiomyocytes
#13
Beáta Bódi, Enikő Pásztorné Tóth, László Nagy, Attila Tóth, Lilla Mártha, Árpád Kovács, György Balla, Tamás Kovács, Zoltán Papp
During the perinatal adaptation process N2BA titin isoforms are switched for N2B titin isoforms leading to an increase in cardiomyocyte passive tension (Fpassive). Here we attempted to reveal how titin isoform composition and oxidative insults (i.e. sulfhydryl (SH)-group oxidation or carbonylation) influence Fpassive of left ventricular (LV) cardiomyocytes during rat heart development. Moreover, we also examined a hypothetical protective role for titin associated small heat shock proteins (sHSPs), Hsp27 and αB-crystallin in the above processes...
September 21, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28935773/a-randomized-double-blinded-phase-ii-trial-of-gemcitabine-and-nab-paclitaxel-plus-apatorsen-or-placebo-in-patients-with-metastatic-pancreatic-cancer-the-rainier-trial
#14
Andrew H Ko, Patrick B Murphy, James D Peyton, Dianna L Shipley, Ahmed Al-Hazzouri, Francisco A Rodriguez, Mark S Womack, Henry Q Xiong, David M Waterhouse, Margaret A Tempero, Shuangli Guo, Cassie M Lane, Chris Earwood, Laura M DeBusk, Johanna C Bendell
LESSONS LEARNED: The addition of the heat shock protein 27 (Hsp27)-targeting antisense oligonucleotide, apatorsen, to a standard first-line chemotherapy regimen did not result in improved survival in unselected patients with metastatic pancreatic cancer.Findings from this trial hint at the possible prognostic and predictive value of serum Hsp27 that may warrant further investigation. BACKGROUND: This randomized, double-blinded, phase II trial evaluated the efficacy of gemcitabine/nab-paclitaxel plus either apatorsen, an antisense oligonucleotide targeting heat shock protein 27 (Hsp27) mRNA, or placebo in patients with metastatic pancreatic cancer...
September 21, 2017: Oncologist
https://www.readbyqxmd.com/read/28925539/expression-and-functional-proteomic-analyses-of-osteocytes-from-xenopus-laevis-tested-under-mechanical-stress-conditions-preliminary-observations-on-an-appropriate-new-animal-model
#15
Jessika Bertacchini, Marta Benincasa, Marta Checchi, Francesco Cavani, Alberto Smargiassi, Marzia Ferretti, Carla Palumbo
Hitherto, the role of the osteocyte as transducer of mechanical stimuli into biological signals is far from settled. In this study, we used an appropriate model represented by the cortex of Xenopus laevis long bone diaphysis lacking (unlike the mammalian one) of vascular structures and containing only osteocytes inside the bone matrix. These structural features allow any change of protein profile that might be observed upon different experimental conditions, such as bone adaptation to stress/mechanical loading, to be ascribed specifically to osteocytes...
September 19, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28917624/small-heat-shock-protein-27-an-effective-adjuvant-for-enhancement-of-hiv-1-nef-antigen-specific-immunity
#16
Alireza Milani, Azam Bolhassani, Sepideh Shahbazi, Fatemeh Motevalli, Seyed Mehdi Sadat, Sepehr Soleymani
Novel vaccine modalities have been designed to improve the efficiency of vaccines against HIV infections. In this way, the HIV-1 Nef protein has been known as an attractive antigenic candidate in therapeutic vaccine development. Moreover, the endogenous adjuvants such as heat shock proteins (HSPs) and high mobility group box 1 protein (HMGB1) have been suggested effectively to induce antigen-specific humoral and cellular immune responses. In this study, different Nef DNA and protein constructs were produced in eukaryotic and prokaryotic expression systems, and their immunostimulatory properties were evaluated using small heat shock protein 27 (Hsp27) and the HMGB1-derived peptide (Hp91) in a mouse model...
September 14, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28915917/translocation-of-molecular-chaperones-to-the-titin-springs-is-common-in-skeletal-myopathy-patients-and-affects-sarcomere-function
#17
Andreas Unger, Lisa Beckendorf, Pierre Böhme, Rudolf Kley, Marion von Frieling-Salewsky, Hanns Lochmüller, Rolf Schröder, Dieter O Fürst, Matthias Vorgerd, Wolfgang A Linke
Myopathies encompass a wide variety of acquired and hereditary disorders. The pathomechanisms include structural and functional changes affecting, e.g., myofiber metabolism and contractile properties. In this study, we observed increased passive tension (PT) of skinned myofibers from patients with myofibrillar myopathy (MFM) caused by FLNC mutations (MFM-filaminopathy) and limb-girdle muscular dystrophy type-2A due to CAPN3 mutations (LGMD2A), compared to healthy control myofibers. Because the giant protein titin determines myofiber PT, we measured its molecular size and the titin-to-myosin ratio, but found no differences between myopathies and controls...
September 15, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/28915362/improved-efficacy-of-hyperthermia-by-auraptene-in-human-colon-adenocarcinoma-cells
#18
Mahdi Moussavi, Farhang Haddad, Matin Matin, Mehrdad Iranshahi, Fatemeh Rassouli
Colon adenocarcinoma is one of the most common cancers worldwide, and resistance to current therapeutic modalities is a serious drawback in its treatment. Auraptene is a natural coumarin with considerable anticancer effects. The goal of present study was to introduce a novel combinatorial approach against colon adenocarcinoma cells. To do so, HT29 cells were pretreated with non-toxic auraptene and then hyperthermia was applied. Afterwards, viability of cells was assessed, changes induced in the cell cycle were analyzed, and expression pattern of candidate genes was studied...
September 15, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28912272/the-transcription-factor-hoxb7-regulates-erk-kinase-activity-and-thereby-stimulates-the-motility-and-invasiveness-of-pancreatic-cancer-cells
#19
Makiko Tsuboi, Keisuke Taniuchi, Takahiro Shimizu, Motoaki Saito, Toshiji Saibara
HOX genes encode transcription factors that function as sequence-specific transcription factors that are involved in cellular proliferation, differentiation, and death. The aim of this study was to investigate the role of a HOX family protein, HOXB7, in the motility and invasiveness of pancreatic cancer cells. We previously identified a HOXB7 transcript that is one of a number of transcripts that are preferentially translated in membrane protrusions in pancreatic cancer cells. Immunocytochemistry showed that HOXB7 was localized to the cell protrusions of migrating pancreatic cancer cells...
September 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28903396/igfbp2-plays-an-important-role-in-heat-shock-protein-27-mediated-cancer-progression-and-metastasis
#20
Chin-Sheng Hung, Chien-Yu Huang, Chia-Hwa Lee, Wei-Yu Chen, Ming-Te Huang, Po-Li Wei, Yu-Jia Chang
Heat shock protein 27 (Hsp27) is a key chaperone that interacts with over 200 client proteins. The expression of Hsp27 might be correlated with poor outcome in many types of cancer. Previous study indicated that Hsp27 might be an important biomarker in hepatocellular carcinoma (HCC). However, the detailed mechanism is less well understood. The shRNA-mediated silencing of Hsp27 decreased the proliferation, migration and invasion of HCC cells. In a xenograft model, the silencing of Hsp27 reduced tumor progression...
August 15, 2017: Oncotarget
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