Christina de Fontnouvelle, Michael Zappitelli, Heather R Thiessen-Philbrook, Yaqi Jia, Paul L Kimmel, James S Kaufman, Prasad Devarajan, Chirag R Parikh, Jason H Greenberg
BACKGROUND: Children who require surgery for congenital heart disease have increased risk for long-term chronic kidney disease (CKD). Clinical factors as well as urine biomarkers of tubular health and injury may help improve the prognostication of estimated glomerular filtration rate (eGFR) decline. METHODS: We enrolled children from 1 month to 18 years old undergoing cardiac surgery in the ASSESS-AKI cohort. We used mixed-effect models to assess the association between urinary biomarkers (log2-transformed uromodulin, NGAL, KIM-1, IL-18, L-FABP) measured 3 months after cardiac surgery and cyanotic heart disease with the rate of eGFR decline at annual in-person visits over 4 years...
February 15, 2023: Pediatric Nephrology