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Thomas Druetz, Nicolas Corneau-Tremblay, Tieba Millogo, Seni Kouanda, Antarou Ly, Abel Bicaba, Slim Haddad
Seasonal malaria chemoprevention (SMC) for children < 5 is a strategy that is gaining popularity in West African countries. Although its efficacy to reduce malaria incidence has been demonstrated in trials, the effects of SMC implemented in routine program conditions, outside of experimental contexts, are unknown. In 2014 and 2015, a survey was conducted in 1,311 households located in Kaya District (Burkina Faso) where SMC had been recently introduced. All children < 72 months were tested for malaria and anemia...
February 2018: American Journal of Tropical Medicine and Hygiene
Thomas Druetz, Abel Bicaba, Telesphore Some, Seni Kouanda, Antarou Ly, Slim Haddad
With solid evidence that free healthcare increases the utilization of health services, Burkina Faso recently exempted all children under five and pregnant women from direct payment at health facilities. However, there is little insight into the capacity to maintain the gains attributable to free healthcare under routine conditions of implementation at the national scale. In particular, the repercussions of its interruption are unknown. The objective is to assess the effects of a sequence of natural interventions including the introduction, interruption and reintroduction of free healthcare on health-seeking practices and utilization of healthcare facilities by children under five...
May 20, 2017: Social Science & Medicine
Federica Fregonese, Kendra Siekmans, Seni Kouanda, Thomas Druetz, Antarou Ly, Souleymane Diabaté, Slim Haddad
BACKGROUND: Stunting affects 165 million children worldwide, with repercussions on their survival and development. A contaminated environment is likely to contribute to stunting: frequent faecal-oral transmission possibly causes environmental enteropathy, a chronic inflammatory disorder that may contribute to faltering growth in children. This study's objective was to assess the effect of contaminated environment on stunting in Burkina Faso, where stunting prevalence is persistently high...
April 2017: Journal of Epidemiology and Community Health
Souleymane Diabaté, Thomas Druetz, Tiéba Millogo, Antarou Ly, Federica Fregonese, Seni Kouanda, Slim Haddad
INTRODUCTION: Larval source management has contributed to malaria decline over the past years. However, little is known about the impact of larval control practices undertaken at the household level on malaria transmission. METHODS: The study was conducted in Kaya health district after the 2010 mass distribution of insecticide treated-nets and the initiation of malaria awareness campaigns in Burkina Faso. The aim was to (i) estimate the level of domestic larval control practices (cleaning of the house and its surroundings, eradication of larval sources, and elimination of hollow objects that might collect water); (ii) identify key determinants; and (iii) explore the structural relationships between these practices, participation in awareness-raising activities and mothers' knowledge/attitudes/practices, and malaria prevalence among under-five children...
2015: PloS One
Thomas Druetz, Federica Fregonese, Aristide Bado, Tieba Millogo, Seni Kouanda, Souleymane Diabaté, Slim Haddad
INTRODUCTION: Burkina Faso started nationwide community case management of malaria (CCMm) in 2010. In 2011, health center user fees for children under five were abolished in some districts. OBJECTIVE: To assess the effects of concurrent implementation of CCMm and user fees abolition on treatment-seeking practices for febrile children. METHODS: This is a natural experiment conducted in the districts of Kaya (CCMm plus user fees abolition) and Zorgho (CCMm only)...
2015: PloS One
Thomas Druetz, Valéry Ridde, Seni Kouanda, Antarou Ly, Souleymane Diabaté, Slim Haddad
BACKGROUND: Malaria is holo-endemic in Burkina Faso and causes approximately 40,000 deaths every year. In 2010, health authorities scaled up community case management of malaria with artemisinin-based combination therapy. Previous trials and pilot project evaluations have shown that this strategy may be feasible, acceptable, and effective under controlled implementation conditions. However, little is known about its effectiveness or feasibility/acceptability under real-world conditions of implementation at national scale...
2015: Malaria Journal
Thomas Druetz, Kadidiatou Kadio, Slim Haddad, Seni Kouanda, Valéry Ridde
The use of community health workers to administer prompt treatments is gaining popularity in most sub-Saharan African countries. Their performance is a key challenge because it varies considerably, depending on the context, while being closely associated with the effectiveness of case management strategies. What determines community health workers' performance is still under debate. Based on a realist perspective, a systematic review recently hypothesized that several mechanisms are associated with good performance and successful community interventions...
January 2015: Social Science & Medicine
Souleymane Diabaté, Thomas Druetz, Emmanuel Bonnet, Seni Kouanda, Valéry Ridde, Slim Haddad
BACKGROUND: Periodic mass distributions contribute significantly to universal access to insecticide-treated nets (ITNs). However, due to the limited number of nets distributed, needs remain unsatisfied, particularly in large households. METHODS: This study was conducted in Kaya health district following the 2010 mass distribution of ITNs in Burkina Faso. Data were collected on the socio-economic and geo-spatial characteristics and ITN possession and utilization levels of 2,004 households...
2014: Malaria Journal
Valéry Ridde, Mabel Carabali, Antarou Ly, Thomas Druetz, Seni Kouanda, Emmanuel Bonnet, Slim Haddad
No abstract text is available yet for this article.
June 2014: PLoS Neglected Tropical Diseases
Thomas Druetz, Kendra Siekmans, Sylvie Goossens, Valéry Ridde, Slim Haddad
Pneumonia causes around 750 000 child deaths per year in sub-Saharan African (SSA) countries. The lack of accessibility to prompt and effective treatment is an important contributor to this burden. Community case management of pneumonia (CCMp) uses trained community health workers (CHWs) to administer antibiotics to suspected child pneumonia cases in villages. This strategy has been gaining momentum in low- and middle-income countries, and the World Health Organization and United Nations children's fund have recently encouraged countries to broaden community case management to other diseases...
March 2015: Health Policy and Planning
Valéry Ridde, Thomas Druetz, Serge Poppy, Seni Kouanda, Slim Haddad
BACKGROUND: Every year 40,000 people die of malaria in Burkina Faso. In 2010, the Burkinabè authorities implemented a national malaria control program that provides for the distribution of mosquito nets and the home-based treatment of children with fever by community health workers. The objective of this study was to measure the implementation fidelity of this program. METHODS: We conducted a case study in two comparable districts (Kaya and Zorgho). Data were collected one year after the program's implementation through field observations (10 weeks), documentary analysis, and individual interviews with stakeholders (n = 48) working at different levels of the program...
2013: PloS One
D H Manicourt, R D Altman, J M Williams, J P Devogelaer, A Druetz-Van Egeren, M E Lenz, D Pietryla, E J Thonar
OBJECTIVE: To relate the rate of bone resorption to serum levels of both hyaluronan (HA) and antigenic keratan sulfate (KS) in canine experimental osteoarthritis (OA) and to evaluate the effects of calcitonin on these parameters and the OA lesions of the unstable knee. METHODS: Twenty-two dogs underwent anterior cruciate ligament transection (ACLT) and 6 dogs underwent sham operation. Urinary pyridinium crosslinks were quantified by high-performance liquid chromatography...
June 1999: Arthritis and Rheumatism
D H Manicourt, A Druetz-Van Egeren, L Haazen, C Nagant de Deuxchaisnes
1. As nonsteroidal anti-inflammatory drugs may impair the ability of the chondrocyte to repair its damaged extracellular matrix, we explored the changes in the metabolism of newly synthesized proteoglycan (PG) and hyaluronan (HA) molecules produced by tenoxicam and aspirin in human normal cartilage explants and in osteoarthritic (OA) cartilage from age-matched donors. 2. Explants were sampled from the medial femoral condyle and were classified by use of Mankin's histological-histochemical grading system. Cartilage specimens were normal in 10 subjects, exhibited moderate OA (MOA) in 10 and had severe OA (SOA) in 10...
December 1994: British Journal of Pharmacology
D H Manicourt, O Cornu, M E Lenz, A Druetz-van Egeren, E J Thonar
OBJECTIVE: To monitor changes in serum levels of hyaluronan (HA) in experimental canine osteoarthritis (OA), and to relate these changes to the level of HA in synovial fluid (SF) and/or to the rate of HA synthesis by synovium. METHODS: OA was induced in 16 dogs by anterior cruciate ligament transection; 7 dogs were sham operated. An immunoassay was used to measure HA levels in serum at various times postsurgery and in SF from OA knees at sacrifice (Week 13 postsurgery)...
February 1995: Journal of Rheumatology
G Vaes, Y Eeckhout, G Lenaers-Claeys, C François-Gillet, J E Druetz
1. A latent neutral proteinase was found in culture media of mouse bone explants. Its accumulation during the cultures is closely parallel to that of procollagenase; both require the presence of heparin in the media. 2. Latent neutral proteinase was activated by several treatments of the media known to activate procollagenase, such as limited proteolysis by trypsin, chymotrypsin, plasmin or kallikrein, dialysis against 3 M-NaSCN at 4 degrees C and prolonged preincubation at 25 degrees C. Its activation often followed that of the procollagenase present in the same media...
May 15, 1978: Biochemical Journal
G Vaes, Y Eeckhout, J E Druetz
No abstract text is available yet for this article.
1976: Archives Internationales de Physiologie et de Biochimie
R F Steiger, F Van Hoof, J Bontemps, M Nyssens-Jadin, J E Druetz
Homogenates from 5 species of Trypanosomatids were screened for the presence of a series of acid hydrolases. The insect flagellae, Crithidia sp., contains 5 enzymes reminiscent of plant parasitism, which were absent from or of very low specific activity in parasites of the genera, Trypanosoma and Leishmania. The latter mammalian parasites, on the other hand, exhibited higher acid proteinase and alpha-D-mannosidase activity levels.
December 1979: Acta Tropica
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